Contact Information

Call us at: (614)722.2700

Center for Perinatal ResearchAbigail Wexner Research Institute700 Children’s DriveColumbus , Ohio 43205 (map)

Learn more about Yusen Liu

Biography

        Yusen Liu, PhD, is a Professor of Pediatrics at The Ohio State University College of Medicine.  Dr. Liu’s NIH-funded research program focuses on the role of MAP kinase phosphatases in host defense against microbial infection.  His research has established MAP kinase phosphatase (MKP)-1 as one of the most important negative regulators of inflammation and a potential target for a variety of inflammatory diseases.

Academic and Clinical Areas

Center for Perinatal Research

Principal Investigator

Neonatology

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Center for Perinatal Research

Research

Lab(s)

Center for Perinatal Research

The Liu laboratory is interested in the regulatory mechanisms that control the innate immunity against microbial infections. Currently, they are mainly carrying out research in two areas. First, they are studying the signaling pathways that regulate the production of inflammatory cytokines. They have found that MAP kinase phosphatase (MKP)-1 plays a pivotal role in the restraint of the inflammatory responses in innate immune cells-by dephosphorylating p38 and JNK, MKP-1 deactivates the stress-activated MAP kinases and inhibits the production of pro-inflammatory cytokines. They hypothesize that defects in MKP-1 gene may sensitize host to inflammatory diseases. Currently, animal models are developed to test this hypothesis using genetics, biochemistry, and molecular biology techniques. Another research project in the laboratory is to understand the role of Redox regulation during immune defense against bacterial and fungal infections. They have found that enzymes responsible for the generation of reduced glutathione are essential for an effective immune defense against both bacterial and fungal pathogens. The long term goals of these research projects are to understand the regulation of inflammation and the critical regulatory mechanisms critical for pathogen elimination. The ultimate goal is to develop novel treatments for inflammatory diseases and to prevent pathogen infections.

View My Publications

Publications

                  Huang L, Ma Y, Guo H, Tang N, Ouyang S, Nuro-Gyina P, Tao L, Liu Y, O'Brien MC, Langdon WY, Zhang J. Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis. J Immunol. 2022 Sep 1; 209: 991-1000.

                


                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Talreja J, Bauerfeld C, Wang X, Hafner M, Liu Y, Samavati L. MKP-1 modulates ubiquitination/phosphorylation of TLR signaling. Life Sci Alliance. 2021 Dec; 4: 

                


                  Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  

                


                  Kirk SG, Murphy PR, Wang X, Cash CJ, Barley TJ, Bowman BA, Batty AJ, Ackerman WE 4th, Zhang J, Nelin LD, Hafner M, Liu Y. Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection. J Immunol. 2021 Jun 15; 206: 2966-2979.

                


                  Chen LL, Zmuda EJ, Talavera MM, Frick J, Brock GN, Liu Y, Klebanoff MA, Trittmann JK. Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia. Pediatr Res. 2020 Jan; 87: 81-87.

                


                  Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.

                


                  Liu GZ, Liu JZ, Li XQ, Zhang L, Li SJ, Xiao TW, Wang JX, Li GY, Liu Y. Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells. Mol Cell Biochem. 2018 Jan; 438: 191-198.

View More Publications

Professional Experience

2010 - Present Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Professor of Pediatrics2003 - Present The Research Institute at Nationwide Children’s Hospital, Principal Investigator2006 - 2010 Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Associate Professor2003 - 2006 Center for Developmental Pharmacology and Toxicology, Children’s Research Institute, Children’s Hospital, Department of Pediatrics, The Ohio State University, Assistant Professor1996 - 2003 Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, NIH, Tenure-track Investigator1995 - 1996 Laboratory of Cellular and Molecula Biology, Gerontology Research Center, National Institute on Aging, NIH, Visiting Associate1992 - 1995 Laboratory of Molecular Genetics, Gerontology Research Center, National Institute on Aging, NIH, Visiting Fellow1991 - 1992 Department of Fermentation Technology, Hiroshima University, Assistant Professor1986 - 1987 Department of Chemical Engineering, Dalian Institute of Technology, Research Associate

Contact Information

Center for Perinatal Research

Call us at: (614)722.2700

                    Abigail Wexner Research Institute700 Children's DriveColumbus , Ohio 43205 (map)

Contact Information

Call us at: (614)722.2700

Center for Perinatal ResearchAbigail Wexner Research Institute700 Children’s DriveColumbus , Ohio 43205 (map)

Learn more about Yusen Liu

Biography

        Yusen Liu, PhD, is a Professor of Pediatrics at The Ohio State University College of Medicine.  Dr. Liu’s NIH-funded research program focuses on the role of MAP kinase phosphatases in host defense against microbial infection.  His research has established MAP kinase phosphatase (MKP)-1 as one of the most important negative regulators of inflammation and a potential target for a variety of inflammatory diseases.

Academic and Clinical Areas

Center for Perinatal Research

Principal Investigator

Neonatology

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Center for Perinatal Research

Research

Lab(s)

Center for Perinatal Research

The Liu laboratory is interested in the regulatory mechanisms that control the innate immunity against microbial infections. Currently, they are mainly carrying out research in two areas. First, they are studying the signaling pathways that regulate the production of inflammatory cytokines. They have found that MAP kinase phosphatase (MKP)-1 plays a pivotal role in the restraint of the inflammatory responses in innate immune cells-by dephosphorylating p38 and JNK, MKP-1 deactivates the stress-activated MAP kinases and inhibits the production of pro-inflammatory cytokines. They hypothesize that defects in MKP-1 gene may sensitize host to inflammatory diseases. Currently, animal models are developed to test this hypothesis using genetics, biochemistry, and molecular biology techniques. Another research project in the laboratory is to understand the role of Redox regulation during immune defense against bacterial and fungal infections. They have found that enzymes responsible for the generation of reduced glutathione are essential for an effective immune defense against both bacterial and fungal pathogens. The long term goals of these research projects are to understand the regulation of inflammation and the critical regulatory mechanisms critical for pathogen elimination. The ultimate goal is to develop novel treatments for inflammatory diseases and to prevent pathogen infections.

View My Publications

Publications

                  Huang L, Ma Y, Guo H, Tang N, Ouyang S, Nuro-Gyina P, Tao L, Liu Y, O'Brien MC, Langdon WY, Zhang J. Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis. J Immunol. 2022 Sep 1; 209: 991-1000.

                


                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Talreja J, Bauerfeld C, Wang X, Hafner M, Liu Y, Samavati L. MKP-1 modulates ubiquitination/phosphorylation of TLR signaling. Life Sci Alliance. 2021 Dec; 4: 

                


                  Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  

                


                  Kirk SG, Murphy PR, Wang X, Cash CJ, Barley TJ, Bowman BA, Batty AJ, Ackerman WE 4th, Zhang J, Nelin LD, Hafner M, Liu Y. Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection. J Immunol. 2021 Jun 15; 206: 2966-2979.

                


                  Chen LL, Zmuda EJ, Talavera MM, Frick J, Brock GN, Liu Y, Klebanoff MA, Trittmann JK. Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia. Pediatr Res. 2020 Jan; 87: 81-87.

                


                  Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.

                


                  Liu GZ, Liu JZ, Li XQ, Zhang L, Li SJ, Xiao TW, Wang JX, Li GY, Liu Y. Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells. Mol Cell Biochem. 2018 Jan; 438: 191-198.

View More Publications

Professional Experience

2010 - Present Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Professor of Pediatrics2003 - Present The Research Institute at Nationwide Children’s Hospital, Principal Investigator2006 - 2010 Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Associate Professor2003 - 2006 Center for Developmental Pharmacology and Toxicology, Children’s Research Institute, Children’s Hospital, Department of Pediatrics, The Ohio State University, Assistant Professor1996 - 2003 Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, NIH, Tenure-track Investigator1995 - 1996 Laboratory of Cellular and Molecula Biology, Gerontology Research Center, National Institute on Aging, NIH, Visiting Associate1992 - 1995 Laboratory of Molecular Genetics, Gerontology Research Center, National Institute on Aging, NIH, Visiting Fellow1991 - 1992 Department of Fermentation Technology, Hiroshima University, Assistant Professor1986 - 1987 Department of Chemical Engineering, Dalian Institute of Technology, Research Associate

Contact Information

Center for Perinatal Research

Call us at: (614)722.2700

                    Abigail Wexner Research Institute700 Children's DriveColumbus , Ohio 43205 (map)

Contact Information

Call us at: (614)722.2700

Center for Perinatal ResearchAbigail Wexner Research Institute700 Children’s DriveColumbus , Ohio 43205 (map)

Learn more about Yusen Liu

Contact Information

  • Call us at:
  • (614)722.2700
  • Center for Perinatal ResearchAbigail Wexner Research Institute700 Children’s DriveColumbus , Ohio 43205 (map)

Learn more about Yusen Liu

Biography

        Yusen Liu, PhD, is a Professor of Pediatrics at The Ohio State University College of Medicine.  Dr. Liu’s NIH-funded research program focuses on the role of MAP kinase phosphatases in host defense against microbial infection.  His research has established MAP kinase phosphatase (MKP)-1 as one of the most important negative regulators of inflammation and a potential target for a variety of inflammatory diseases.

Biography

        Yusen Liu, PhD, is a Professor of Pediatrics at The Ohio State University College of Medicine.  Dr. Liu’s NIH-funded research program focuses on the role of MAP kinase phosphatases in host defense against microbial infection.  His research has established MAP kinase phosphatase (MKP)-1 as one of the most important negative regulators of inflammation and a potential target for a variety of inflammatory diseases.

Biography

        Yusen Liu, PhD, is a Professor of Pediatrics at The Ohio State University College of Medicine.  Dr. Liu’s NIH-funded research program focuses on the role of MAP kinase phosphatases in host defense against microbial infection.  His research has established MAP kinase phosphatase (MKP)-1 as one of the most important negative regulators of inflammation and a potential target for a variety of inflammatory diseases.



      






        Yusen Liu, PhD, is a Professor of Pediatrics at The Ohio State University College of Medicine.  Dr. Liu’s NIH-funded research program focuses on the role of MAP kinase phosphatases in host defense against microbial infection.  His research has established MAP kinase phosphatase (MKP)-1 as one of the most important negative regulators of inflammation and a potential target for a variety of inflammatory diseases.

Academic and Clinical Areas

Center for Perinatal Research

Principal Investigator

Neonatology

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Center for Perinatal Research

Academic and Clinical Areas

Center for Perinatal Research

Principal Investigator

Neonatology

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Center for Perinatal Research

Academic and Clinical Areas

Center for Perinatal Research

Principal Investigator

Neonatology

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Center for Perinatal Research

Center for Perinatal Research

Principal Investigator

Neonatology

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Center for Perinatal Research

  • Center for Perinatal Research
  • Principal Investigator
  • Neonatology
  • Principal Investigator
  • Neonatology Fellowship
  • Faculty
  • Primary Department
  • Center for Perinatal Research

Research

Lab(s)

Center for Perinatal Research

The Liu laboratory is interested in the regulatory mechanisms that control the innate immunity against microbial infections. Currently, they are mainly carrying out research in two areas. First, they are studying the signaling pathways that regulate the production of inflammatory cytokines. They have found that MAP kinase phosphatase (MKP)-1 plays a pivotal role in the restraint of the inflammatory responses in innate immune cells-by dephosphorylating p38 and JNK, MKP-1 deactivates the stress-activated MAP kinases and inhibits the production of pro-inflammatory cytokines. They hypothesize that defects in MKP-1 gene may sensitize host to inflammatory diseases. Currently, animal models are developed to test this hypothesis using genetics, biochemistry, and molecular biology techniques. Another research project in the laboratory is to understand the role of Redox regulation during immune defense against bacterial and fungal infections. They have found that enzymes responsible for the generation of reduced glutathione are essential for an effective immune defense against both bacterial and fungal pathogens. The long term goals of these research projects are to understand the regulation of inflammation and the critical regulatory mechanisms critical for pathogen elimination. The ultimate goal is to develop novel treatments for inflammatory diseases and to prevent pathogen infections.

View My Publications

Publications

                  Huang L, Ma Y, Guo H, Tang N, Ouyang S, Nuro-Gyina P, Tao L, Liu Y, O'Brien MC, Langdon WY, Zhang J. Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis. J Immunol. 2022 Sep 1; 209: 991-1000.

                


                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Talreja J, Bauerfeld C, Wang X, Hafner M, Liu Y, Samavati L. MKP-1 modulates ubiquitination/phosphorylation of TLR signaling. Life Sci Alliance. 2021 Dec; 4: 

                


                  Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  

                


                  Kirk SG, Murphy PR, Wang X, Cash CJ, Barley TJ, Bowman BA, Batty AJ, Ackerman WE 4th, Zhang J, Nelin LD, Hafner M, Liu Y. Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection. J Immunol. 2021 Jun 15; 206: 2966-2979.

                


                  Chen LL, Zmuda EJ, Talavera MM, Frick J, Brock GN, Liu Y, Klebanoff MA, Trittmann JK. Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia. Pediatr Res. 2020 Jan; 87: 81-87.

                


                  Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.

                


                  Liu GZ, Liu JZ, Li XQ, Zhang L, Li SJ, Xiao TW, Wang JX, Li GY, Liu Y. Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells. Mol Cell Biochem. 2018 Jan; 438: 191-198.

View More Publications

Research

Lab(s)

Center for Perinatal Research

The Liu laboratory is interested in the regulatory mechanisms that control the innate immunity against microbial infections. Currently, they are mainly carrying out research in two areas. First, they are studying the signaling pathways that regulate the production of inflammatory cytokines. They have found that MAP kinase phosphatase (MKP)-1 plays a pivotal role in the restraint of the inflammatory responses in innate immune cells-by dephosphorylating p38 and JNK, MKP-1 deactivates the stress-activated MAP kinases and inhibits the production of pro-inflammatory cytokines. They hypothesize that defects in MKP-1 gene may sensitize host to inflammatory diseases. Currently, animal models are developed to test this hypothesis using genetics, biochemistry, and molecular biology techniques. Another research project in the laboratory is to understand the role of Redox regulation during immune defense against bacterial and fungal infections. They have found that enzymes responsible for the generation of reduced glutathione are essential for an effective immune defense against both bacterial and fungal pathogens. The long term goals of these research projects are to understand the regulation of inflammation and the critical regulatory mechanisms critical for pathogen elimination. The ultimate goal is to develop novel treatments for inflammatory diseases and to prevent pathogen infections.

View My Publications

Publications

                  Huang L, Ma Y, Guo H, Tang N, Ouyang S, Nuro-Gyina P, Tao L, Liu Y, O'Brien MC, Langdon WY, Zhang J. Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis. J Immunol. 2022 Sep 1; 209: 991-1000.

                


                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Talreja J, Bauerfeld C, Wang X, Hafner M, Liu Y, Samavati L. MKP-1 modulates ubiquitination/phosphorylation of TLR signaling. Life Sci Alliance. 2021 Dec; 4: 

                


                  Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  

                


                  Kirk SG, Murphy PR, Wang X, Cash CJ, Barley TJ, Bowman BA, Batty AJ, Ackerman WE 4th, Zhang J, Nelin LD, Hafner M, Liu Y. Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection. J Immunol. 2021 Jun 15; 206: 2966-2979.

                


                  Chen LL, Zmuda EJ, Talavera MM, Frick J, Brock GN, Liu Y, Klebanoff MA, Trittmann JK. Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia. Pediatr Res. 2020 Jan; 87: 81-87.

                


                  Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.

                


                  Liu GZ, Liu JZ, Li XQ, Zhang L, Li SJ, Xiao TW, Wang JX, Li GY, Liu Y. Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells. Mol Cell Biochem. 2018 Jan; 438: 191-198.

View More Publications

Research

Lab(s)

Center for Perinatal Research

The Liu laboratory is interested in the regulatory mechanisms that control the innate immunity against microbial infections. Currently, they are mainly carrying out research in two areas. First, they are studying the signaling pathways that regulate the production of inflammatory cytokines. They have found that MAP kinase phosphatase (MKP)-1 plays a pivotal role in the restraint of the inflammatory responses in innate immune cells-by dephosphorylating p38 and JNK, MKP-1 deactivates the stress-activated MAP kinases and inhibits the production of pro-inflammatory cytokines. They hypothesize that defects in MKP-1 gene may sensitize host to inflammatory diseases. Currently, animal models are developed to test this hypothesis using genetics, biochemistry, and molecular biology techniques. Another research project in the laboratory is to understand the role of Redox regulation during immune defense against bacterial and fungal infections. They have found that enzymes responsible for the generation of reduced glutathione are essential for an effective immune defense against both bacterial and fungal pathogens. The long term goals of these research projects are to understand the regulation of inflammation and the critical regulatory mechanisms critical for pathogen elimination. The ultimate goal is to develop novel treatments for inflammatory diseases and to prevent pathogen infections.

View My Publications

Publications

                  Huang L, Ma Y, Guo H, Tang N, Ouyang S, Nuro-Gyina P, Tao L, Liu Y, O'Brien MC, Langdon WY, Zhang J. Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis. J Immunol. 2022 Sep 1; 209: 991-1000.

                


                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Talreja J, Bauerfeld C, Wang X, Hafner M, Liu Y, Samavati L. MKP-1 modulates ubiquitination/phosphorylation of TLR signaling. Life Sci Alliance. 2021 Dec; 4: 

                


                  Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  

                


                  Kirk SG, Murphy PR, Wang X, Cash CJ, Barley TJ, Bowman BA, Batty AJ, Ackerman WE 4th, Zhang J, Nelin LD, Hafner M, Liu Y. Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection. J Immunol. 2021 Jun 15; 206: 2966-2979.

                


                  Chen LL, Zmuda EJ, Talavera MM, Frick J, Brock GN, Liu Y, Klebanoff MA, Trittmann JK. Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia. Pediatr Res. 2020 Jan; 87: 81-87.

                


                  Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.

                


                  Liu GZ, Liu JZ, Li XQ, Zhang L, Li SJ, Xiao TW, Wang JX, Li GY, Liu Y. Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells. Mol Cell Biochem. 2018 Jan; 438: 191-198.

View More Publications

Lab(s)

Center for Perinatal Research

The Liu laboratory is interested in the regulatory mechanisms that control the innate immunity against microbial infections. Currently, they are mainly carrying out research in two areas. First, they are studying the signaling pathways that regulate the production of inflammatory cytokines. They have found that MAP kinase phosphatase (MKP)-1 plays a pivotal role in the restraint of the inflammatory responses in innate immune cells-by dephosphorylating p38 and JNK, MKP-1 deactivates the stress-activated MAP kinases and inhibits the production of pro-inflammatory cytokines. They hypothesize that defects in MKP-1 gene may sensitize host to inflammatory diseases. Currently, animal models are developed to test this hypothesis using genetics, biochemistry, and molecular biology techniques. Another research project in the laboratory is to understand the role of Redox regulation during immune defense against bacterial and fungal infections. They have found that enzymes responsible for the generation of reduced glutathione are essential for an effective immune defense against both bacterial and fungal pathogens. The long term goals of these research projects are to understand the regulation of inflammation and the critical regulatory mechanisms critical for pathogen elimination. The ultimate goal is to develop novel treatments for inflammatory diseases and to prevent pathogen infections.

View My Publications

Publications

                  Huang L, Ma Y, Guo H, Tang N, Ouyang S, Nuro-Gyina P, Tao L, Liu Y, O'Brien MC, Langdon WY, Zhang J. Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis. J Immunol. 2022 Sep 1; 209: 991-1000.

                


                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Talreja J, Bauerfeld C, Wang X, Hafner M, Liu Y, Samavati L. MKP-1 modulates ubiquitination/phosphorylation of TLR signaling. Life Sci Alliance. 2021 Dec; 4: 

                


                  Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  

                


                  Kirk SG, Murphy PR, Wang X, Cash CJ, Barley TJ, Bowman BA, Batty AJ, Ackerman WE 4th, Zhang J, Nelin LD, Hafner M, Liu Y. Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection. J Immunol. 2021 Jun 15; 206: 2966-2979.

                


                  Chen LL, Zmuda EJ, Talavera MM, Frick J, Brock GN, Liu Y, Klebanoff MA, Trittmann JK. Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia. Pediatr Res. 2020 Jan; 87: 81-87.

                


                  Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.

                


                  Liu GZ, Liu JZ, Li XQ, Zhang L, Li SJ, Xiao TW, Wang JX, Li GY, Liu Y. Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells. Mol Cell Biochem. 2018 Jan; 438: 191-198.

View More Publications

Lab(s)

Center for Perinatal Research

The Liu laboratory is interested in the regulatory mechanisms that control the innate immunity against microbial infections. Currently, they are mainly carrying out research in two areas. First, they are studying the signaling pathways that regulate the production of inflammatory cytokines. They have found that MAP kinase phosphatase (MKP)-1 plays a pivotal role in the restraint of the inflammatory responses in innate immune cells-by dephosphorylating p38 and JNK, MKP-1 deactivates the stress-activated MAP kinases and inhibits the production of pro-inflammatory cytokines. They hypothesize that defects in MKP-1 gene may sensitize host to inflammatory diseases. Currently, animal models are developed to test this hypothesis using genetics, biochemistry, and molecular biology techniques. Another research project in the laboratory is to understand the role of Redox regulation during immune defense against bacterial and fungal infections. They have found that enzymes responsible for the generation of reduced glutathione are essential for an effective immune defense against both bacterial and fungal pathogens. The long term goals of these research projects are to understand the regulation of inflammation and the critical regulatory mechanisms critical for pathogen elimination. The ultimate goal is to develop novel treatments for inflammatory diseases and to prevent pathogen infections.

Lab(s)

Center for Perinatal Research

  • Center for Perinatal Research

  • View My Publications

                    Huang L, Ma Y, Guo H, Tang N, Ouyang S, Nuro-Gyina P, Tao L, Liu Y, O'Brien MC, Langdon WY, Zhang J. Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis. J Immunol. 2022 Sep 1; 209: 991-1000.



                Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.



                Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  



                Talreja J, Bauerfeld C, Wang X, Hafner M, Liu Y, Samavati L. MKP-1 modulates ubiquitination/phosphorylation of TLR signaling. Life Sci Alliance. 2021 Dec; 4: 



                Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  



                Kirk SG, Murphy PR, Wang X, Cash CJ, Barley TJ, Bowman BA, Batty AJ, Ackerman WE 4th, Zhang J, Nelin LD, Hafner M, Liu Y. Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection. J Immunol. 2021 Jun 15; 206: 2966-2979.



                Chen LL, Zmuda EJ, Talavera MM, Frick J, Brock GN, Liu Y, Klebanoff MA, Trittmann JK. Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia. Pediatr Res. 2020 Jan; 87: 81-87.



                Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.



                Liu GZ, Liu JZ, Li XQ, Zhang L, Li SJ, Xiao TW, Wang JX, Li GY, Liu Y. Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells. Mol Cell Biochem. 2018 Jan; 438: 191-198.

View More Publications

  • Huang L, Ma Y, Guo H, Tang N, Ouyang S, Nuro-Gyina P, Tao L, Liu Y, O’Brien MC, Langdon WY, Zhang J. Akt-2 Is a Potential Therapeutic Target for Disseminated Candidiasis. J Immunol. 2022 Sep 1; 209: 991-1000.
  • Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13; 101938.
  • Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;
  • Talreja J, Bauerfeld C, Wang X, Hafner M, Liu Y, Samavati L. MKP-1 modulates ubiquitination/phosphorylation of TLR signaling. Life Sci Alliance. 2021 Dec; 4:
  • Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;
  • Kirk SG, Murphy PR, Wang X, Cash CJ, Barley TJ, Bowman BA, Batty AJ, Ackerman WE 4th, Zhang J, Nelin LD, Hafner M, Liu Y. Knockout of MAPK Phosphatase-1 Exaggerates Type I IFN Response during Systemic Escherichia coli Infection. J Immunol. 2021 Jun 15; 206: 2966-2979.
  • Chen LL, Zmuda EJ, Talavera MM, Frick J, Brock GN, Liu Y, Klebanoff MA, Trittmann JK. Dual-specificity phosphatase (DUSP) genetic variants predict pulmonary hypertension in patients with bronchopulmonary dysplasia. Pediatr Res. 2020 Jan; 87: 81-87.
  • Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.
  • Liu GZ, Liu JZ, Li XQ, Zhang L, Li SJ, Xiao TW, Wang JX, Li GY, Liu Y. Knockdown of eukaryotic translation initiation factor 3 subunit D (eIF3D) inhibits proliferation of acute myeloid leukemia cells. Mol Cell Biochem. 2018 Jan; 438: 191-198.

Professional Experience

2010 - Present Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Professor of Pediatrics2003 - Present The Research Institute at Nationwide Children’s Hospital, Principal Investigator2006 - 2010 Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Associate Professor2003 - 2006 Center for Developmental Pharmacology and Toxicology, Children’s Research Institute, Children’s Hospital, Department of Pediatrics, The Ohio State University, Assistant Professor1996 - 2003 Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, NIH, Tenure-track Investigator1995 - 1996 Laboratory of Cellular and Molecula Biology, Gerontology Research Center, National Institute on Aging, NIH, Visiting Associate1992 - 1995 Laboratory of Molecular Genetics, Gerontology Research Center, National Institute on Aging, NIH, Visiting Fellow1991 - 1992 Department of Fermentation Technology, Hiroshima University, Assistant Professor1986 - 1987 Department of Chemical Engineering, Dalian Institute of Technology, Research Associate

Professional Experience

2010 - Present Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Professor of Pediatrics2003 - Present The Research Institute at Nationwide Children’s Hospital, Principal Investigator2006 - 2010 Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Associate Professor2003 - 2006 Center for Developmental Pharmacology and Toxicology, Children’s Research Institute, Children’s Hospital, Department of Pediatrics, The Ohio State University, Assistant Professor1996 - 2003 Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, NIH, Tenure-track Investigator1995 - 1996 Laboratory of Cellular and Molecula Biology, Gerontology Research Center, National Institute on Aging, NIH, Visiting Associate1992 - 1995 Laboratory of Molecular Genetics, Gerontology Research Center, National Institute on Aging, NIH, Visiting Fellow1991 - 1992 Department of Fermentation Technology, Hiroshima University, Assistant Professor1986 - 1987 Department of Chemical Engineering, Dalian Institute of Technology, Research Associate

Professional Experience

2010 - Present Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Professor of Pediatrics2003 - Present The Research Institute at Nationwide Children’s Hospital, Principal Investigator2006 - 2010 Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Associate Professor2003 - 2006 Center for Developmental Pharmacology and Toxicology, Children’s Research Institute, Children’s Hospital, Department of Pediatrics, The Ohio State University, Assistant Professor1996 - 2003 Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, NIH, Tenure-track Investigator1995 - 1996 Laboratory of Cellular and Molecula Biology, Gerontology Research Center, National Institute on Aging, NIH, Visiting Associate1992 - 1995 Laboratory of Molecular Genetics, Gerontology Research Center, National Institute on Aging, NIH, Visiting Fellow1991 - 1992 Department of Fermentation Technology, Hiroshima University, Assistant Professor1986 - 1987 Department of Chemical Engineering, Dalian Institute of Technology, Research Associate

2010 - Present Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Professor of Pediatrics2003 - Present The Research Institute at Nationwide Children’s Hospital, Principal Investigator2006 - 2010 Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Associate Professor2003 - 2006 Center for Developmental Pharmacology and Toxicology, Children’s Research Institute, Children’s Hospital, Department of Pediatrics, The Ohio State University, Assistant Professor1996 - 2003 Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, NIH, Tenure-track Investigator1995 - 1996 Laboratory of Cellular and Molecula Biology, Gerontology Research Center, National Institute on Aging, NIH, Visiting Associate1992 - 1995 Laboratory of Molecular Genetics, Gerontology Research Center, National Institute on Aging, NIH, Visiting Fellow1991 - 1992 Department of Fermentation Technology, Hiroshima University, Assistant Professor1986 - 1987 Department of Chemical Engineering, Dalian Institute of Technology, Research Associate

2010 - Present Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Department of Pediatrics, The Ohio State University, Professor of Pediatrics

Contact Information

Center for Perinatal Research

Call us at: (614)722.2700

                    Abigail Wexner Research Institute700 Children's DriveColumbus , Ohio 43205 (map)

Contact Information

Center for Perinatal Research

Call us at: (614)722.2700

                    Abigail Wexner Research Institute700 Children's DriveColumbus , Ohio 43205 (map)

Contact Information

Center for Perinatal Research

Call us at: (614)722.2700

                    Abigail Wexner Research Institute700 Children's DriveColumbus , Ohio 43205 (map)

Center for Perinatal Research

Call us at: (614)722.2700

                    Abigail Wexner Research Institute700 Children's DriveColumbus , Ohio 43205 (map)

Call us at: (614)722.2700

                    Abigail Wexner Research Institute700 Children's DriveColumbus , Ohio 43205 (map)

Call us at: (614)722.2700

                    Abigail Wexner Research Institute700 Children's DriveColumbus , Ohio 43205 (map)
  • Call us at:
  • (614)722.2700
  • Abigail Wexner Research Institute700 Children’s DriveColumbus , Ohio 43205 (map)