Wang Lab

Ruoning Wang, PhD Principal Investigator Ruoning Wang, PhD, is a principal investigator in the Center for Childhood Cancer for The Research Institute at Nationwide Children’s Hospital, a principal investigator for the Division of Hematology and Oncology at Nationwide Children’s Hospital and an associate professor in the Department of Pediatrics at The Ohio State University College of Medicine. Dr. Wang earned his bachelor’s degree in Medicinal Chemistry from China Pharmaceutical University, followed by an MS degree in Biochemistry from Nanjing Medical University and a PhD degree in Gene & Development from the University of Texas, MD Anderson Cancer Center (UT-MDACC). He trained in Immunology and Cancer Biology at St Jude Children’s Research Hospital as a postdoctoral fellow and joined The Research Institute at Nationwide Children’s Hospital as a principal investigator and The Ohio State University as an assistant professor of pediatrics in August 2013.

Lingling Liu Research Scientist Lingling.Liu@NatiowideChildrens.org My roles include lab Management and mouse colony management.

Xuequn Xu Research Associate My research interests include T cell biology and immunology.

Josephin Gnanaprakasam Josephin.Gnanaprakasam@NationwideChildrens.org My research is focused on understanding the interplay between metabolic reprogramming and T cell differentiation to enhance anti-tumor immune response.

Xuyong Chen Post Doctoral Scientist Xuyong.Chen@NationwideChildrens.org Xuyong’s research focus on T cells metabolic reprogramming, cell cycle and DNA damage.

Tingting Wang Postdoctoral Researcher Tingting.Wang@NationwideChildrens.org

Ruohan Wu Graduate Research Associate Ruohan.Wu@NationwideChildrens.org Ruohan Wu is a PhD candidate in molecular biology at The Ohio State University. My current research interest is T cell metabolism. During T cell activation and differentiation, the metabolic file is dramatically switched which helps the T cell better achieve its physiological function. However, the dysregulation of this complex signaling cascade leads to pathogenic conditions, such as autoimmune disease. By deciphering the metabolic reprogramming during T cell activation and differentiation, I hope to apply my knowledge to translational use and combat autoimmune disease.

John Sherman Graduate Student John’s research interests include integration of metabolic and cell cycle signaling.

Featured Research

Xuyong Chen, Benjamin Sunkel, Meng Wang, Siwen Kang, Tingting Wang, JN Rashida Gnanaprakasam, Lingling Liu, Teresa A. Cassel, David A. Scott, Ana M. Muñoz-Cabello, Jose Lopez-Barneo, Jun Yang, Andrew N. Lane, Gang Xin, Benjamin Stanton, Teresa W.-M. Fan, and Ruoning Wang. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation Science Immunology (In press) Download Full Text PDF (Supplemental Materials) Free-access Published Manuscript Online Ruohan Wu, Xuuyong Chen, Siwen Kang, Tingting Wang, JN Rashida Gnanaprakasam, Lingling Liu, Yufeng Yao, Song Guo Zheng, Gaofeng Fan, Mark R Burns, and Ruoning Wang. De novo synthesis and salvage pathway coordinately regulates polyamine homeostasis and determines T cell proliferation and function. Science Advances 2020 Dec 16;6(51):eabc4275. doi: 10.1126/sciadv.abc4275 PMID: 33328226 PMCID: PMC7744078 Tingting Wang, JN Rashida Gnanaprakasam, Xuyong Chen, Siwen Kang, Xuequn Xu, Hua Sun, Lingling Liu, Hayley Rodgers, Ethan Miller, Teresa A. Cassel, Qiushi Sun, Sara Vicente-Munoz, Marc O. Warmoes, Penghui Lin, Zayda Lizbether Piedra-Qiuntero, Mireia Guerau-de-Arellano, Kevin Cassady, Song Guo Zheng, Jun Yang, Andrew N. Lane, Xiaotong Song, Teresa W.-M. Fan, and Ruoning Wang. Inosine is an alternative carbon source for CD8+ T cell function under glucose restriction. Nature Metabolism 2020 Jul;2(7):635-647. doi: 10.1038/s42255-020-0219-4, PMID: 32694789, PMCID: PMC7371628 Gaojian Lian, JN Rashida Gnanaprakasam, Tingting Wang, Ruohan Wu, Xuyong Chen, Lingling Liu, Yuqing Shen, Mao Yang, Jun Yang, Ying Chen, Vasilis Vasiliou, Teresa A. Cassel, Douglas R. Green, Yusen Liu, Teresa W.-M. Fan and Ruoning Wang. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. Elife. 2018 doi: 10.7554/eLife.36158. PMID:30198844 Siwen Kang, Lingling Liu, Tingting Wang, Matthew Cannon, Penghui Lin, Teresa W-M Fan, David A Scott, Hsin-Jung Joyce Wu, Andrew N Lane, Ruoning Wang. GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation. Nat Metab. 2022 Oct 3. doi: 10.1038/s42255-022-00638-1, PMID: 36192601.

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Ruoning Wang, PhD Principal Investigator

Ruoning Wang, PhD, is a principal investigator in the Center for Childhood Cancer for The Research Institute at Nationwide Children’s Hospital, a principal investigator for the Division of Hematology and Oncology at Nationwide Children’s Hospital and an associate professor in the Department of Pediatrics at The Ohio State University College of Medicine.

Dr. Wang earned his bachelor’s degree in Medicinal Chemistry from China Pharmaceutical University, followed by an MS degree in Biochemistry from Nanjing Medical University and a PhD degree in Gene & Development from the University of Texas, MD Anderson Cancer Center (UT-MDACC). He trained in Immunology and Cancer Biology at St Jude Children’s Research Hospital as a postdoctoral fellow and joined The Research Institute at Nationwide Children’s Hospital as a principal investigator and The Ohio State University as an assistant professor of pediatrics in August 2013.

Lingling Liu Research Scientist Lingling.Liu@NatiowideChildrens.org My roles include lab Management and mouse colony management.

Xuequn Xu Research Associate My research interests include T cell biology and immunology.

Xuyong Chen Post Doctoral Scientist Xuyong.Chen@NationwideChildrens.org Xuyong’s research focus on T cells metabolic reprogramming, cell cycle and DNA damage.

Tingting Wang Postdoctoral Researcher Tingting.Wang@NationwideChildrens.org

John Sherman Graduate Student John’s research interests include integration of metabolic and cell cycle signaling.

Featured Research

View Full Bibliography

Lingling Liu Research Scientist Lingling.Liu@NatiowideChildrens.org My roles include lab Management and mouse colony management.

Lingling Liu Research Scientist Lingling.Liu@NatiowideChildrens.org

My roles include lab Management and mouse colony management.

Xuequn Xu Research Associate My research interests include T cell biology and immunology.

Xuequn Xu Research Associate

My research interests include T cell biology and immunology.

Josephin Gnanaprakasam Josephin.Gnanaprakasam@NationwideChildrens.org

My research is focused on understanding the interplay between metabolic reprogramming and T cell differentiation to enhance anti-tumor immune response.

Xuyong Chen Post Doctoral Scientist Xuyong.Chen@NationwideChildrens.org Xuyong’s research focus on T cells metabolic reprogramming, cell cycle and DNA damage.

Xuyong Chen Post Doctoral Scientist Xuyong.Chen@NationwideChildrens.org

Xuyong’s research focus on T cells metabolic reprogramming, cell cycle and DNA damage.

Tingting Wang Postdoctoral Researcher Tingting.Wang@NationwideChildrens.org

Ruohan Wu Graduate Research Associate Ruohan.Wu@NationwideChildrens.org

Ruohan Wu is a PhD candidate in molecular biology at The Ohio State University. My current research interest is T cell metabolism. During T cell activation and differentiation, the metabolic file is dramatically switched which helps the T cell better achieve its physiological function. However, the dysregulation of this complex signaling cascade leads to pathogenic conditions, such as autoimmune disease. By deciphering the metabolic reprogramming during T cell activation and differentiation, I hope to apply my knowledge to translational use and combat autoimmune disease.

John Sherman Graduate Student John’s research interests include integration of metabolic and cell cycle signaling.

John Sherman Graduate Student

John’s research interests include integration of metabolic and cell cycle signaling.

Featured Research

View Full Bibliography

Xuyong Chen, Benjamin Sunkel, Meng Wang, Siwen Kang, Tingting Wang, JN Rashida Gnanaprakasam, Lingling Liu, Teresa A. Cassel, David A. Scott, Ana M. Muñoz-Cabello, Jose Lopez-Barneo, Jun Yang, Andrew N. Lane, Gang Xin, Benjamin Stanton, Teresa W.-M. Fan, and Ruoning Wang. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation Science Immunology (In press)
Download Full Text PDF (Supplemental Materials)
Free-access Published Manuscript Online
Ruohan Wu, Xuuyong Chen, Siwen Kang, Tingting Wang, JN Rashida Gnanaprakasam, Lingling Liu, Yufeng Yao, Song Guo Zheng, Gaofeng Fan, Mark R Burns, and Ruoning Wang. De novo synthesis and salvage pathway coordinately regulates polyamine homeostasis and determines T cell proliferation and function. Science Advances 2020 Dec 16;6(51):eabc4275. doi: 10.1126/sciadv.abc4275 PMID: 33328226 PMCID: PMC7744078
Tingting Wang, JN Rashida Gnanaprakasam, Xuyong Chen, Siwen Kang, Xuequn Xu, Hua Sun, Lingling Liu, Hayley Rodgers, Ethan Miller, Teresa A. Cassel, Qiushi Sun, Sara Vicente-Munoz, Marc O. Warmoes, Penghui Lin, Zayda Lizbether Piedra-Qiuntero, Mireia Guerau-de-Arellano, Kevin Cassady, Song Guo Zheng, Jun Yang, Andrew N. Lane, Xiaotong Song, Teresa W.-M. Fan, and Ruoning Wang. Inosine is an alternative carbon source for CD8+ T cell function under glucose restriction. Nature Metabolism 2020 Jul;2(7):635-647. doi: 10.1038/s42255-020-0219-4, PMID: 32694789, PMCID: PMC7371628
Gaojian Lian, JN Rashida Gnanaprakasam, Tingting Wang, Ruohan Wu, Xuyong Chen, Lingling Liu, Yuqing Shen, Mao Yang, Jun Yang, Ying Chen, Vasilis Vasiliou, Teresa A. Cassel, Douglas R. Green, Yusen Liu, Teresa W.-M. Fan and Ruoning Wang. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. Elife. 2018 doi: 10.7554/eLife.36158. PMID:30198844
Siwen Kang, Lingling Liu, Tingting Wang, Matthew Cannon, Penghui Lin, Teresa W-M Fan, David A Scott, Hsin-Jung Joyce Wu, Andrew N Lane, Ruoning Wang. GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation. Nat Metab. 2022 Oct 3. doi: 10.1038/s42255-022-00638-1, PMID: 36192601.

View Full Bibliography