Vidu Garg

Contact Information

Call us at: (614) 722-2530

Fax us at: (614) 722-2549

PediatricsCardiology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Vidu Garg

Biography

Vidu Garg, MD is Director of the Center for Cardiovascular Research and the Nationwide Foundation Endowed Chair in Cardiovascular Research at Nationwide Children’s Hospital in Columbus, Ohio. He is a Professor in the Department of Pediatrics and holds an adjunct appointment in the Department of Molecular Genetics at The Ohio State University. He also serves as Director of Translational Research and is a board-certified practicing pediatric cardiologist in the Heart Center at Nationwide Children’s Hospital. Dr. Garg completed his pediatric residency at Nationwide Children’s Hospital in 1997 after which he spent five years at University of Texas Southwestern completing his pediatric cardiology training and a post-doctoral research fellowship in cardiac development and cardiovascular genetics. Subsequently, he joined the faculty at University of Texas Southwestern before returning to Nationwide Children’s. Dr. Garg’s research laboratory focuses on molecular pathways controlling cardiac development and the genetics of congenital heart disease. 

See Vidu Garg’s Curriculum Vitae (CV)

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Academic and Clinical Areas

Center for Cardiovascular Research

Director

22q Center

Physician Team

Heart Center

Physician Team

Vidu Garg Lab

Principal Investigator

Cardiology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Cardiology

Research

Lab(s)

Center for Cardiovascular Research

The laboratory focuses on understanding the genetic basis of congenital heart disease and the molecular pathways regulating normal and abnormal cardiac development. We have identified familial cases of congenital heart disease and used traditional linkage studies to discover novel genetic etiologies of human congenital cardiac malformations. In addition, we are interesting in understanding how these mutations disrupt normal cardiac development and are generating mouse models to gain insight into the molecular basis of congenital heart disease.

View My Publications

Publications

                  Ye S, Wang C, Xu Z, Lin H, Wan X, Yu Y, Adhicary S, Zhang JZ, Zhou Y, Liu C, Alonzo M, Bi J, Ramirez-Navarro A, Deschenes I, Ma Q, Garg V, Wu JC, Zhao MT. Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency. Circ Res. 2022 Dec 30;  

                


                  Backes CH, Hill KD, Shelton EL, Slaughter JL, Lewis TR, Weisz DE, Mah ML, Bhombal S, Smith CV, McNamara PJ, Benitz WE, Garg V. Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider. J Am Heart Assoc. 2022 Sep 6; 11: e025784.

                


                  Manivannan S, Mansfield C, Zhang X, Kodigepalli KM, Majumdar U, Garg V, Basu M. Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia. Commun Biol. 2022 Aug 15; 5: 820.

                


                  Choudhury TZ, Garg V. Molecular genetic mechanisms of congenital heart disease. Curr Opin Genet Dev. 2022 Jul 8; 75: 101949.

                


                  Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.

                


                  Gordon DM, Cunningham D, Zender G, Lawrence PJ, Penaloza JS, Lin H, Fitzgerald-Butt SM, Myers K, Duong T, Corsmeier DJ, Gaither JB, Kuck HC, Wijeratne S, Moreland B, Kelly BJ, Baylor-Johns Hopkins Center for Mendelian Genomics., Garg V, White P, McBride KL. Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery. PLoS Genet. 2022 Jun 23; 18: e1010236.

                


                  Hall B, Alonzo M, Texter K, Garg V, Zhao MT. Probing single ventricle heart defects with patient-derived induced pluripotent stem cells and emerging technologies. Birth Defects Res. 2022 Feb 24;  

                


                  Kraler S, Garg V, Akhmedov A. Calcific aortic valve disease: novel insights into nitric oxide signalling. Eur Heart J. 2022 Feb 21;  

                


                  Majumdar U, Choudhury TZ, Manivannan S, Ueyama Y, Basu M, Garg V. Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide. Front Cardiovasc Med. 2022; 9: 742850.

                


                  Bennett JS, Gordon DM, Majumdar U, Lawrence PJ, Matos-Nieves A, Myers K, Kamp AN, Leonard JC, McBride KL, White P, Garg V. Use of machine learning to classify high-risk variants of uncertain significance in lamin A/C cardiac disease. Heart Rhythm. 2021 Dec 24;  

                


                  Choudhury TZ, Majumdar U, Basu M, Garg V. Impact of maternal hyperglycemia on cardiac development: Insights from animal models. Genesis. 2021 Nov; 59: e23449.

                


                  Yasuhara J, Garg V. Genetics of congenital heart disease: a narrative review of recent advances and clinical implications. Transl Pediatr. 2021 Sep; 10: 2366-2386.

                


                  Teekakirikul P, Zhu W, Gabriel GC, Young CB, Williams K, Martin LJ, Hill JC, Richards T, Billaud M, Phillippi JA, Wang J, Wu Y, Tan T, Devine W, Lin JH, Bais AS, Klonowski J, de Bellaing AM, Saini A, Wang MX, Emerel L, Salamacha N, Wyman SK, Lee C, Sing Li H, Miron A, Zhang J, Xing J, McNamara DM, Fung E, Kirshbom P, Mahle W, Kochilas LK, He Y, Garg V, White P, McBride KL, Benson DW, Gleason TG, Mital S, Lo CW. Common deletion variants causing protocadherin-a deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease. HGG Adv. 2021 Jul 8; 2: 

                


                  Audain E, Wilsdon A, Breckpot J, Izarzugaza JMG, Fitzgerald TW, Kahlert AK, Sifrim A, Wünnemann F, Perez-Riverol Y, Abdul-Khaliq H, Bak M, Bassett AS, Benson DW, Berger F, Daehnert I, Devriendt K, Dittrich S, Daubeney PE, Garg V, Hackmann K, Hoff K, Hofmann P, Dombrowsky G, Pickardt T, Bauer U, Keavney BD, Klaassen S, Kramer HH, Marshall CR, Milewicz DM, Lemaire S, Coselli JS, Mitchell ME, Tomita-Mitchell A, Prakash SK, Stamm K, Stewart AFR, Silversides CK, Siebert R, Stiller B, Rosenfeld JA, Vater I, Postma AV, Caliebe A, Brook JD, Andelfinger G, Hurles ME, Thienpont B, Larsen LA, Hitz MP. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. PLoS Genet. 2021 Jul; 17: e1009679.

                


                  Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 

                


                  Matos-Nieves A, Manivannan S, Majumdar U, McBride KL, White P, Garg V. A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes. Front Cardiovasc Med. 2021; 8: 683074.

                


                  Lin H, McBride KL, Garg V, Zhao MT. Decoding Genetics of Congenital Heart Disease Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs). Front Cell Dev Biol. 2021; 9: 630069.

                


                  Manivannan SN, Darouich S, Masmoudi A, Gordon D, Zender G, Han Z, Fitzgerald-Butt S, White P, McBride KL, Kharrat M, Garg V. Novel frameshift variant in MYL2 reveals molecular differences between dominant and recessive forms of hypertrophic cardiomyopathy. PLoS Genet. 2020 May; 16: e1008639.

                


                  Majumdar U, Yasuhara J, Garg V. In Vivo and In Vitro Genetic Models of Congenital Heart Disease. Cold Spring Harb Perspect Biol. 2019 Dec 9;  

                


                  Bennett JS, Bernhardt M, McBride KL, Reshmi SC, Zmuda E, Kertesz NJ, Garg V, Fitzgerald-Butt S, Kamp AN. Reclassification of Variants of Uncertain Significance in Children with Inherited Arrhythmia Syndromes is Predicted by Clinical Factors. Pediatr Cardiol. 2019 Dec; 40: 1679-1687.

                


                  LaHaye S, Majumdar U, Yasuhara J, Koenig SN, Matos-Nieves A, Kumar R, Garg V. Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation. Dis Model Mech. 2019 Jun 24; 12: 

                


                  Basu M, Trask AJ, Garg V. Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome. Am J Physiol Heart Circ Physiol. 2019 May 1; 316: H1141-H1143.

                


                  Matos-Nieves A, Yasuhara J, Garg V. Another Notch in the Genetic Puzzle of Tetralogy of Fallot. Circ Res. 2019 Feb 15; 124: 462-464.

                


                  Pierpont ME, Brueckner M, Chung WK, Garg V, Lacro RV, McGuire AL, Mital S, Priest JR, Pu WT, Roberts A, Ware SM, Gelb BD, Russell MW, American Heart Association Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Genomic and Precision Medicine.. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 Nov 20; 138: e653-e711.

                


                  Garg V. The Role of Lipoprotein(a) in Calcific Aortic Valve Disease: Insights From a Large-Cohort Genetic Study. JAMA Cardiol. 2018 Jan 1; 3: 24-25.

                


                  Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 

                


                  Basu M, Zhu JY, LaHaye S, Majumdar U, Jiao K, Han Z, Garg V. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease. JCI Insight. 2017 Oct 19; 2: 

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 07/31/2009

Board Certifications

Pediatric Cardiology

Fellowship

University of Texas Southwestern Medical Center

Date Completed: 06/30/2002

Fellowship

Children’s Medical Center of Dallas

Date Completed: 06/30/2000

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/1997

Medical School

Jefferson Medical College

Date Completed: 06/10/1994

Professional Experience

2016 - Present Department of Pediatrics, The Ohio State University, Professor2015 - Present Center for Cardiovascular Research, Director2009 - Present The Heart Center Center for Cardiovascular Research, Nationwide Children’s Hospital, Director of Translational Research2009 - Present Department of Molecular Genetics, The Ohio State University, Professor2009 - 2016 Department of Molecular Genetics, The Ohio State University, Associate Professor2009 - 2016 Department of Pediatrics, The Ohio State University, Associate Professor2005 - 2009 Department of Molecular Biology, University of Texas Southwestern Medical Center, Assistant Professor2005 - 2009 McDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Assistant Professor2002 - 2009 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Professor2002 - 2009 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Professor2000 - 2002 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Instructor1994 - 1997 Department of Pediatrics, The Ohio State University College of Medicine, Clinical Instructor

Contact Information

Pediatrics

Call us at: (614) 722-2530

Fax us at: (614) 722-2549

                    Cardiology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-2530

Fax us at: (614) 722-2549

PediatricsCardiology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Vidu Garg

Biography

Vidu Garg, MD is Director of the Center for Cardiovascular Research and the Nationwide Foundation Endowed Chair in Cardiovascular Research at Nationwide Children’s Hospital in Columbus, Ohio. He is a Professor in the Department of Pediatrics and holds an adjunct appointment in the Department of Molecular Genetics at The Ohio State University. He also serves as Director of Translational Research and is a board-certified practicing pediatric cardiologist in the Heart Center at Nationwide Children’s Hospital. Dr. Garg completed his pediatric residency at Nationwide Children’s Hospital in 1997 after which he spent five years at University of Texas Southwestern completing his pediatric cardiology training and a post-doctoral research fellowship in cardiac development and cardiovascular genetics. Subsequently, he joined the faculty at University of Texas Southwestern before returning to Nationwide Children’s. Dr. Garg’s research laboratory focuses on molecular pathways controlling cardiac development and the genetics of congenital heart disease. 

See Vidu Garg’s Curriculum Vitae (CV)

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Academic and Clinical Areas

Center for Cardiovascular Research

Director

22q Center

Physician Team

Heart Center

Physician Team

Vidu Garg Lab

Principal Investigator

Cardiology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Cardiology

Research

Lab(s)

Center for Cardiovascular Research

The laboratory focuses on understanding the genetic basis of congenital heart disease and the molecular pathways regulating normal and abnormal cardiac development. We have identified familial cases of congenital heart disease and used traditional linkage studies to discover novel genetic etiologies of human congenital cardiac malformations. In addition, we are interesting in understanding how these mutations disrupt normal cardiac development and are generating mouse models to gain insight into the molecular basis of congenital heart disease.

View My Publications

Publications

                  Ye S, Wang C, Xu Z, Lin H, Wan X, Yu Y, Adhicary S, Zhang JZ, Zhou Y, Liu C, Alonzo M, Bi J, Ramirez-Navarro A, Deschenes I, Ma Q, Garg V, Wu JC, Zhao MT. Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency. Circ Res. 2022 Dec 30;  

                


                  Backes CH, Hill KD, Shelton EL, Slaughter JL, Lewis TR, Weisz DE, Mah ML, Bhombal S, Smith CV, McNamara PJ, Benitz WE, Garg V. Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider. J Am Heart Assoc. 2022 Sep 6; 11: e025784.

                


                  Manivannan S, Mansfield C, Zhang X, Kodigepalli KM, Majumdar U, Garg V, Basu M. Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia. Commun Biol. 2022 Aug 15; 5: 820.

                


                  Choudhury TZ, Garg V. Molecular genetic mechanisms of congenital heart disease. Curr Opin Genet Dev. 2022 Jul 8; 75: 101949.

                


                  Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.

                


                  Gordon DM, Cunningham D, Zender G, Lawrence PJ, Penaloza JS, Lin H, Fitzgerald-Butt SM, Myers K, Duong T, Corsmeier DJ, Gaither JB, Kuck HC, Wijeratne S, Moreland B, Kelly BJ, Baylor-Johns Hopkins Center for Mendelian Genomics., Garg V, White P, McBride KL. Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery. PLoS Genet. 2022 Jun 23; 18: e1010236.

                


                  Hall B, Alonzo M, Texter K, Garg V, Zhao MT. Probing single ventricle heart defects with patient-derived induced pluripotent stem cells and emerging technologies. Birth Defects Res. 2022 Feb 24;  

                


                  Kraler S, Garg V, Akhmedov A. Calcific aortic valve disease: novel insights into nitric oxide signalling. Eur Heart J. 2022 Feb 21;  

                


                  Majumdar U, Choudhury TZ, Manivannan S, Ueyama Y, Basu M, Garg V. Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide. Front Cardiovasc Med. 2022; 9: 742850.

                


                  Bennett JS, Gordon DM, Majumdar U, Lawrence PJ, Matos-Nieves A, Myers K, Kamp AN, Leonard JC, McBride KL, White P, Garg V. Use of machine learning to classify high-risk variants of uncertain significance in lamin A/C cardiac disease. Heart Rhythm. 2021 Dec 24;  

                


                  Choudhury TZ, Majumdar U, Basu M, Garg V. Impact of maternal hyperglycemia on cardiac development: Insights from animal models. Genesis. 2021 Nov; 59: e23449.

                


                  Yasuhara J, Garg V. Genetics of congenital heart disease: a narrative review of recent advances and clinical implications. Transl Pediatr. 2021 Sep; 10: 2366-2386.

                


                  Teekakirikul P, Zhu W, Gabriel GC, Young CB, Williams K, Martin LJ, Hill JC, Richards T, Billaud M, Phillippi JA, Wang J, Wu Y, Tan T, Devine W, Lin JH, Bais AS, Klonowski J, de Bellaing AM, Saini A, Wang MX, Emerel L, Salamacha N, Wyman SK, Lee C, Sing Li H, Miron A, Zhang J, Xing J, McNamara DM, Fung E, Kirshbom P, Mahle W, Kochilas LK, He Y, Garg V, White P, McBride KL, Benson DW, Gleason TG, Mital S, Lo CW. Common deletion variants causing protocadherin-a deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease. HGG Adv. 2021 Jul 8; 2: 

                


                  Audain E, Wilsdon A, Breckpot J, Izarzugaza JMG, Fitzgerald TW, Kahlert AK, Sifrim A, Wünnemann F, Perez-Riverol Y, Abdul-Khaliq H, Bak M, Bassett AS, Benson DW, Berger F, Daehnert I, Devriendt K, Dittrich S, Daubeney PE, Garg V, Hackmann K, Hoff K, Hofmann P, Dombrowsky G, Pickardt T, Bauer U, Keavney BD, Klaassen S, Kramer HH, Marshall CR, Milewicz DM, Lemaire S, Coselli JS, Mitchell ME, Tomita-Mitchell A, Prakash SK, Stamm K, Stewart AFR, Silversides CK, Siebert R, Stiller B, Rosenfeld JA, Vater I, Postma AV, Caliebe A, Brook JD, Andelfinger G, Hurles ME, Thienpont B, Larsen LA, Hitz MP. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. PLoS Genet. 2021 Jul; 17: e1009679.

                


                  Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 

                


                  Matos-Nieves A, Manivannan S, Majumdar U, McBride KL, White P, Garg V. A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes. Front Cardiovasc Med. 2021; 8: 683074.

                


                  Lin H, McBride KL, Garg V, Zhao MT. Decoding Genetics of Congenital Heart Disease Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs). Front Cell Dev Biol. 2021; 9: 630069.

                


                  Manivannan SN, Darouich S, Masmoudi A, Gordon D, Zender G, Han Z, Fitzgerald-Butt S, White P, McBride KL, Kharrat M, Garg V. Novel frameshift variant in MYL2 reveals molecular differences between dominant and recessive forms of hypertrophic cardiomyopathy. PLoS Genet. 2020 May; 16: e1008639.

                


                  Majumdar U, Yasuhara J, Garg V. In Vivo and In Vitro Genetic Models of Congenital Heart Disease. Cold Spring Harb Perspect Biol. 2019 Dec 9;  

                


                  Bennett JS, Bernhardt M, McBride KL, Reshmi SC, Zmuda E, Kertesz NJ, Garg V, Fitzgerald-Butt S, Kamp AN. Reclassification of Variants of Uncertain Significance in Children with Inherited Arrhythmia Syndromes is Predicted by Clinical Factors. Pediatr Cardiol. 2019 Dec; 40: 1679-1687.

                


                  LaHaye S, Majumdar U, Yasuhara J, Koenig SN, Matos-Nieves A, Kumar R, Garg V. Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation. Dis Model Mech. 2019 Jun 24; 12: 

                


                  Basu M, Trask AJ, Garg V. Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome. Am J Physiol Heart Circ Physiol. 2019 May 1; 316: H1141-H1143.

                


                  Matos-Nieves A, Yasuhara J, Garg V. Another Notch in the Genetic Puzzle of Tetralogy of Fallot. Circ Res. 2019 Feb 15; 124: 462-464.

                


                  Pierpont ME, Brueckner M, Chung WK, Garg V, Lacro RV, McGuire AL, Mital S, Priest JR, Pu WT, Roberts A, Ware SM, Gelb BD, Russell MW, American Heart Association Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Genomic and Precision Medicine.. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 Nov 20; 138: e653-e711.

                


                  Garg V. The Role of Lipoprotein(a) in Calcific Aortic Valve Disease: Insights From a Large-Cohort Genetic Study. JAMA Cardiol. 2018 Jan 1; 3: 24-25.

                


                  Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 

                


                  Basu M, Zhu JY, LaHaye S, Majumdar U, Jiao K, Han Z, Garg V. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease. JCI Insight. 2017 Oct 19; 2: 

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 07/31/2009

Board Certifications

Pediatric Cardiology

Fellowship

University of Texas Southwestern Medical Center

Date Completed: 06/30/2002

Fellowship

Children’s Medical Center of Dallas

Date Completed: 06/30/2000

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/1997

Medical School

Jefferson Medical College

Date Completed: 06/10/1994

Professional Experience

2016 - Present Department of Pediatrics, The Ohio State University, Professor2015 - Present Center for Cardiovascular Research, Director2009 - Present The Heart Center Center for Cardiovascular Research, Nationwide Children’s Hospital, Director of Translational Research2009 - Present Department of Molecular Genetics, The Ohio State University, Professor2009 - 2016 Department of Molecular Genetics, The Ohio State University, Associate Professor2009 - 2016 Department of Pediatrics, The Ohio State University, Associate Professor2005 - 2009 Department of Molecular Biology, University of Texas Southwestern Medical Center, Assistant Professor2005 - 2009 McDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Assistant Professor2002 - 2009 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Professor2002 - 2009 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Professor2000 - 2002 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Instructor1994 - 1997 Department of Pediatrics, The Ohio State University College of Medicine, Clinical Instructor

Contact Information

Pediatrics

Call us at: (614) 722-2530

Fax us at: (614) 722-2549

                    Cardiology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-2530

Fax us at: (614) 722-2549

PediatricsCardiology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Vidu Garg

Contact Information

• Call us at:
• (614) 722-2530
• Fax us at:
• (614) 722-2549
• PediatricsCardiology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Vidu Garg

Biography

Vidu Garg, MD is Director of the Center for Cardiovascular Research and the Nationwide Foundation Endowed Chair in Cardiovascular Research at Nationwide Children’s Hospital in Columbus, Ohio. He is a Professor in the Department of Pediatrics and holds an adjunct appointment in the Department of Molecular Genetics at The Ohio State University. He also serves as Director of Translational Research and is a board-certified practicing pediatric cardiologist in the Heart Center at Nationwide Children’s Hospital. Dr. Garg completed his pediatric residency at Nationwide Children’s Hospital in 1997 after which he spent five years at University of Texas Southwestern completing his pediatric cardiology training and a post-doctoral research fellowship in cardiac development and cardiovascular genetics. Subsequently, he joined the faculty at University of Texas Southwestern before returning to Nationwide Children’s. Dr. Garg’s research laboratory focuses on molecular pathways controlling cardiac development and the genetics of congenital heart disease. 

See Vidu Garg’s Curriculum Vitae (CV)

Biography

Vidu Garg, MD is Director of the Center for Cardiovascular Research and the Nationwide Foundation Endowed Chair in Cardiovascular Research at Nationwide Children’s Hospital in Columbus, Ohio. He is a Professor in the Department of Pediatrics and holds an adjunct appointment in the Department of Molecular Genetics at The Ohio State University. He also serves as Director of Translational Research and is a board-certified practicing pediatric cardiologist in the Heart Center at Nationwide Children’s Hospital. Dr. Garg completed his pediatric residency at Nationwide Children’s Hospital in 1997 after which he spent five years at University of Texas Southwestern completing his pediatric cardiology training and a post-doctoral research fellowship in cardiac development and cardiovascular genetics. Subsequently, he joined the faculty at University of Texas Southwestern before returning to Nationwide Children’s. Dr. Garg’s research laboratory focuses on molecular pathways controlling cardiac development and the genetics of congenital heart disease. 

See Vidu Garg’s Curriculum Vitae (CV)

Biography

Vidu Garg, MD is Director of the Center for Cardiovascular Research and the Nationwide Foundation Endowed Chair in Cardiovascular Research at Nationwide Children’s Hospital in Columbus, Ohio. He is a Professor in the Department of Pediatrics and holds an adjunct appointment in the Department of Molecular Genetics at The Ohio State University. He also serves as Director of Translational Research and is a board-certified practicing pediatric cardiologist in the Heart Center at Nationwide Children’s Hospital. Dr. Garg completed his pediatric residency at Nationwide Children’s Hospital in 1997 after which he spent five years at University of Texas Southwestern completing his pediatric cardiology training and a post-doctoral research fellowship in cardiac development and cardiovascular genetics. Subsequently, he joined the faculty at University of Texas Southwestern before returning to Nationwide Children’s. Dr. Garg’s research laboratory focuses on molecular pathways controlling cardiac development and the genetics of congenital heart disease. 

See Vidu Garg’s Curriculum Vitae (CV)

Vidu Garg, MD is Director of the Center for Cardiovascular Research and the Nationwide Foundation Endowed Chair in Cardiovascular Research at Nationwide Children’s Hospital in Columbus, Ohio. He is a Professor in the Department of Pediatrics and holds an adjunct appointment in the Department of Molecular Genetics at The Ohio State University. He also serves as Director of Translational Research and is a board-certified practicing pediatric cardiologist in the Heart Center at Nationwide Children’s Hospital. Dr. Garg completed his pediatric residency at Nationwide Children’s Hospital in 1997 after which he spent five years at University of Texas Southwestern completing his pediatric cardiology training and a post-doctoral research fellowship in cardiac development and cardiovascular genetics. Subsequently, he joined the faculty at University of Texas Southwestern before returning to Nationwide Children’s. Dr. Garg’s research laboratory focuses on molecular pathways controlling cardiac development and the genetics of congenital heart disease. 

See Vidu Garg’s Curriculum Vitae (CV)

Vidu Garg, MD is Director of the Center for Cardiovascular Research and the Nationwide Foundation Endowed Chair in Cardiovascular Research at Nationwide Children’s Hospital in Columbus, Ohio. He is a Professor in the Department of Pediatrics and holds an adjunct appointment in the Department of Molecular Genetics at The Ohio State University. He also serves as Director of Translational Research and is a board-certified practicing pediatric cardiologist in the Heart Center at Nationwide Children’s Hospital. Dr. Garg completed his pediatric residency at Nationwide Children’s Hospital in 1997 after which he spent five years at University of Texas Southwestern completing his pediatric cardiology training and a post-doctoral research fellowship in cardiac development and cardiovascular genetics. Subsequently, he joined the faculty at University of Texas Southwestern before returning to Nationwide Children’s. Dr. Garg’s research laboratory focuses on molecular pathways controlling cardiac development and the genetics of congenital heart disease. 

See Vidu Garg’s Curriculum Vitae (CV)

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Locations

Main Campus of Nationwide Children’s Hospital

Locations

Main Campus of Nationwide Children’s Hospital

Locations

Main Campus of Nationwide Children’s Hospital

• Main Campus of Nationwide Children’s Hospital

Academic and Clinical Areas

Center for Cardiovascular Research

Director

22q Center

Physician Team

Heart Center

Physician Team

Vidu Garg Lab

Principal Investigator

Cardiology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Cardiology

Academic and Clinical Areas

Center for Cardiovascular Research

Director

22q Center

Physician Team

Heart Center

Physician Team

Vidu Garg Lab

Principal Investigator

Cardiology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Cardiology

Academic and Clinical Areas

Center for Cardiovascular Research

Director

22q Center

Physician Team

Heart Center

Physician Team

Vidu Garg Lab

Principal Investigator

Cardiology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Cardiology

Center for Cardiovascular Research

Director

22q Center

Physician Team

Heart Center

Physician Team

Vidu Garg Lab

Principal Investigator

Cardiology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Cardiology

• Center for Cardiovascular Research
• Director
• 22q Center
• Physician Team
• Heart Center
• Physician Team
• Vidu Garg Lab
• Principal Investigator
• Cardiology Fellowship
• Faculty
• Primary Department
• Pediatrics
• Primary Section
• Cardiology

Research

Lab(s)

Center for Cardiovascular Research

The laboratory focuses on understanding the genetic basis of congenital heart disease and the molecular pathways regulating normal and abnormal cardiac development. We have identified familial cases of congenital heart disease and used traditional linkage studies to discover novel genetic etiologies of human congenital cardiac malformations. In addition, we are interesting in understanding how these mutations disrupt normal cardiac development and are generating mouse models to gain insight into the molecular basis of congenital heart disease.

View My Publications

Publications

                  Ye S, Wang C, Xu Z, Lin H, Wan X, Yu Y, Adhicary S, Zhang JZ, Zhou Y, Liu C, Alonzo M, Bi J, Ramirez-Navarro A, Deschenes I, Ma Q, Garg V, Wu JC, Zhao MT. Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency. Circ Res. 2022 Dec 30;  

                


                  Backes CH, Hill KD, Shelton EL, Slaughter JL, Lewis TR, Weisz DE, Mah ML, Bhombal S, Smith CV, McNamara PJ, Benitz WE, Garg V. Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider. J Am Heart Assoc. 2022 Sep 6; 11: e025784.

                


                  Manivannan S, Mansfield C, Zhang X, Kodigepalli KM, Majumdar U, Garg V, Basu M. Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia. Commun Biol. 2022 Aug 15; 5: 820.

                


                  Choudhury TZ, Garg V. Molecular genetic mechanisms of congenital heart disease. Curr Opin Genet Dev. 2022 Jul 8; 75: 101949.

                


                  Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.

                


                  Gordon DM, Cunningham D, Zender G, Lawrence PJ, Penaloza JS, Lin H, Fitzgerald-Butt SM, Myers K, Duong T, Corsmeier DJ, Gaither JB, Kuck HC, Wijeratne S, Moreland B, Kelly BJ, Baylor-Johns Hopkins Center for Mendelian Genomics., Garg V, White P, McBride KL. Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery. PLoS Genet. 2022 Jun 23; 18: e1010236.

                


                  Hall B, Alonzo M, Texter K, Garg V, Zhao MT. Probing single ventricle heart defects with patient-derived induced pluripotent stem cells and emerging technologies. Birth Defects Res. 2022 Feb 24;  

                


                  Kraler S, Garg V, Akhmedov A. Calcific aortic valve disease: novel insights into nitric oxide signalling. Eur Heart J. 2022 Feb 21;  

                


                  Majumdar U, Choudhury TZ, Manivannan S, Ueyama Y, Basu M, Garg V. Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide. Front Cardiovasc Med. 2022; 9: 742850.

                


                  Bennett JS, Gordon DM, Majumdar U, Lawrence PJ, Matos-Nieves A, Myers K, Kamp AN, Leonard JC, McBride KL, White P, Garg V. Use of machine learning to classify high-risk variants of uncertain significance in lamin A/C cardiac disease. Heart Rhythm. 2021 Dec 24;  

                


                  Choudhury TZ, Majumdar U, Basu M, Garg V. Impact of maternal hyperglycemia on cardiac development: Insights from animal models. Genesis. 2021 Nov; 59: e23449.

                


                  Yasuhara J, Garg V. Genetics of congenital heart disease: a narrative review of recent advances and clinical implications. Transl Pediatr. 2021 Sep; 10: 2366-2386.

                


                  Teekakirikul P, Zhu W, Gabriel GC, Young CB, Williams K, Martin LJ, Hill JC, Richards T, Billaud M, Phillippi JA, Wang J, Wu Y, Tan T, Devine W, Lin JH, Bais AS, Klonowski J, de Bellaing AM, Saini A, Wang MX, Emerel L, Salamacha N, Wyman SK, Lee C, Sing Li H, Miron A, Zhang J, Xing J, McNamara DM, Fung E, Kirshbom P, Mahle W, Kochilas LK, He Y, Garg V, White P, McBride KL, Benson DW, Gleason TG, Mital S, Lo CW. Common deletion variants causing protocadherin-a deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease. HGG Adv. 2021 Jul 8; 2: 

                


                  Audain E, Wilsdon A, Breckpot J, Izarzugaza JMG, Fitzgerald TW, Kahlert AK, Sifrim A, Wünnemann F, Perez-Riverol Y, Abdul-Khaliq H, Bak M, Bassett AS, Benson DW, Berger F, Daehnert I, Devriendt K, Dittrich S, Daubeney PE, Garg V, Hackmann K, Hoff K, Hofmann P, Dombrowsky G, Pickardt T, Bauer U, Keavney BD, Klaassen S, Kramer HH, Marshall CR, Milewicz DM, Lemaire S, Coselli JS, Mitchell ME, Tomita-Mitchell A, Prakash SK, Stamm K, Stewart AFR, Silversides CK, Siebert R, Stiller B, Rosenfeld JA, Vater I, Postma AV, Caliebe A, Brook JD, Andelfinger G, Hurles ME, Thienpont B, Larsen LA, Hitz MP. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. PLoS Genet. 2021 Jul; 17: e1009679.

                


                  Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 

                


                  Matos-Nieves A, Manivannan S, Majumdar U, McBride KL, White P, Garg V. A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes. Front Cardiovasc Med. 2021; 8: 683074.

                


                  Lin H, McBride KL, Garg V, Zhao MT. Decoding Genetics of Congenital Heart Disease Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs). Front Cell Dev Biol. 2021; 9: 630069.

                


                  Manivannan SN, Darouich S, Masmoudi A, Gordon D, Zender G, Han Z, Fitzgerald-Butt S, White P, McBride KL, Kharrat M, Garg V. Novel frameshift variant in MYL2 reveals molecular differences between dominant and recessive forms of hypertrophic cardiomyopathy. PLoS Genet. 2020 May; 16: e1008639.

                


                  Majumdar U, Yasuhara J, Garg V. In Vivo and In Vitro Genetic Models of Congenital Heart Disease. Cold Spring Harb Perspect Biol. 2019 Dec 9;  

                


                  Bennett JS, Bernhardt M, McBride KL, Reshmi SC, Zmuda E, Kertesz NJ, Garg V, Fitzgerald-Butt S, Kamp AN. Reclassification of Variants of Uncertain Significance in Children with Inherited Arrhythmia Syndromes is Predicted by Clinical Factors. Pediatr Cardiol. 2019 Dec; 40: 1679-1687.

                


                  LaHaye S, Majumdar U, Yasuhara J, Koenig SN, Matos-Nieves A, Kumar R, Garg V. Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation. Dis Model Mech. 2019 Jun 24; 12: 

                


                  Basu M, Trask AJ, Garg V. Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome. Am J Physiol Heart Circ Physiol. 2019 May 1; 316: H1141-H1143.

                


                  Matos-Nieves A, Yasuhara J, Garg V. Another Notch in the Genetic Puzzle of Tetralogy of Fallot. Circ Res. 2019 Feb 15; 124: 462-464.

                


                  Pierpont ME, Brueckner M, Chung WK, Garg V, Lacro RV, McGuire AL, Mital S, Priest JR, Pu WT, Roberts A, Ware SM, Gelb BD, Russell MW, American Heart Association Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Genomic and Precision Medicine.. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 Nov 20; 138: e653-e711.

                


                  Garg V. The Role of Lipoprotein(a) in Calcific Aortic Valve Disease: Insights From a Large-Cohort Genetic Study. JAMA Cardiol. 2018 Jan 1; 3: 24-25.

                


                  Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 

                


                  Basu M, Zhu JY, LaHaye S, Majumdar U, Jiao K, Han Z, Garg V. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease. JCI Insight. 2017 Oct 19; 2: 

View More Publications

Research

Lab(s)

Center for Cardiovascular Research

The laboratory focuses on understanding the genetic basis of congenital heart disease and the molecular pathways regulating normal and abnormal cardiac development. We have identified familial cases of congenital heart disease and used traditional linkage studies to discover novel genetic etiologies of human congenital cardiac malformations. In addition, we are interesting in understanding how these mutations disrupt normal cardiac development and are generating mouse models to gain insight into the molecular basis of congenital heart disease.

View My Publications

Publications

                  Ye S, Wang C, Xu Z, Lin H, Wan X, Yu Y, Adhicary S, Zhang JZ, Zhou Y, Liu C, Alonzo M, Bi J, Ramirez-Navarro A, Deschenes I, Ma Q, Garg V, Wu JC, Zhao MT. Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency. Circ Res. 2022 Dec 30;  

                


                  Backes CH, Hill KD, Shelton EL, Slaughter JL, Lewis TR, Weisz DE, Mah ML, Bhombal S, Smith CV, McNamara PJ, Benitz WE, Garg V. Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider. J Am Heart Assoc. 2022 Sep 6; 11: e025784.

                


                  Manivannan S, Mansfield C, Zhang X, Kodigepalli KM, Majumdar U, Garg V, Basu M. Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia. Commun Biol. 2022 Aug 15; 5: 820.

                


                  Choudhury TZ, Garg V. Molecular genetic mechanisms of congenital heart disease. Curr Opin Genet Dev. 2022 Jul 8; 75: 101949.

                


                  Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.

                


                  Gordon DM, Cunningham D, Zender G, Lawrence PJ, Penaloza JS, Lin H, Fitzgerald-Butt SM, Myers K, Duong T, Corsmeier DJ, Gaither JB, Kuck HC, Wijeratne S, Moreland B, Kelly BJ, Baylor-Johns Hopkins Center for Mendelian Genomics., Garg V, White P, McBride KL. Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery. PLoS Genet. 2022 Jun 23; 18: e1010236.

                


                  Hall B, Alonzo M, Texter K, Garg V, Zhao MT. Probing single ventricle heart defects with patient-derived induced pluripotent stem cells and emerging technologies. Birth Defects Res. 2022 Feb 24;  

                


                  Kraler S, Garg V, Akhmedov A. Calcific aortic valve disease: novel insights into nitric oxide signalling. Eur Heart J. 2022 Feb 21;  

                


                  Majumdar U, Choudhury TZ, Manivannan S, Ueyama Y, Basu M, Garg V. Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide. Front Cardiovasc Med. 2022; 9: 742850.

                


                  Bennett JS, Gordon DM, Majumdar U, Lawrence PJ, Matos-Nieves A, Myers K, Kamp AN, Leonard JC, McBride KL, White P, Garg V. Use of machine learning to classify high-risk variants of uncertain significance in lamin A/C cardiac disease. Heart Rhythm. 2021 Dec 24;  

                


                  Choudhury TZ, Majumdar U, Basu M, Garg V. Impact of maternal hyperglycemia on cardiac development: Insights from animal models. Genesis. 2021 Nov; 59: e23449.

                


                  Yasuhara J, Garg V. Genetics of congenital heart disease: a narrative review of recent advances and clinical implications. Transl Pediatr. 2021 Sep; 10: 2366-2386.

                


                  Teekakirikul P, Zhu W, Gabriel GC, Young CB, Williams K, Martin LJ, Hill JC, Richards T, Billaud M, Phillippi JA, Wang J, Wu Y, Tan T, Devine W, Lin JH, Bais AS, Klonowski J, de Bellaing AM, Saini A, Wang MX, Emerel L, Salamacha N, Wyman SK, Lee C, Sing Li H, Miron A, Zhang J, Xing J, McNamara DM, Fung E, Kirshbom P, Mahle W, Kochilas LK, He Y, Garg V, White P, McBride KL, Benson DW, Gleason TG, Mital S, Lo CW. Common deletion variants causing protocadherin-a deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease. HGG Adv. 2021 Jul 8; 2: 

                


                  Audain E, Wilsdon A, Breckpot J, Izarzugaza JMG, Fitzgerald TW, Kahlert AK, Sifrim A, Wünnemann F, Perez-Riverol Y, Abdul-Khaliq H, Bak M, Bassett AS, Benson DW, Berger F, Daehnert I, Devriendt K, Dittrich S, Daubeney PE, Garg V, Hackmann K, Hoff K, Hofmann P, Dombrowsky G, Pickardt T, Bauer U, Keavney BD, Klaassen S, Kramer HH, Marshall CR, Milewicz DM, Lemaire S, Coselli JS, Mitchell ME, Tomita-Mitchell A, Prakash SK, Stamm K, Stewart AFR, Silversides CK, Siebert R, Stiller B, Rosenfeld JA, Vater I, Postma AV, Caliebe A, Brook JD, Andelfinger G, Hurles ME, Thienpont B, Larsen LA, Hitz MP. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. PLoS Genet. 2021 Jul; 17: e1009679.

                


                  Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 

                


                  Matos-Nieves A, Manivannan S, Majumdar U, McBride KL, White P, Garg V. A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes. Front Cardiovasc Med. 2021; 8: 683074.

                


                  Lin H, McBride KL, Garg V, Zhao MT. Decoding Genetics of Congenital Heart Disease Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs). Front Cell Dev Biol. 2021; 9: 630069.

                


                  Manivannan SN, Darouich S, Masmoudi A, Gordon D, Zender G, Han Z, Fitzgerald-Butt S, White P, McBride KL, Kharrat M, Garg V. Novel frameshift variant in MYL2 reveals molecular differences between dominant and recessive forms of hypertrophic cardiomyopathy. PLoS Genet. 2020 May; 16: e1008639.

                


                  Majumdar U, Yasuhara J, Garg V. In Vivo and In Vitro Genetic Models of Congenital Heart Disease. Cold Spring Harb Perspect Biol. 2019 Dec 9;  

                


                  Bennett JS, Bernhardt M, McBride KL, Reshmi SC, Zmuda E, Kertesz NJ, Garg V, Fitzgerald-Butt S, Kamp AN. Reclassification of Variants of Uncertain Significance in Children with Inherited Arrhythmia Syndromes is Predicted by Clinical Factors. Pediatr Cardiol. 2019 Dec; 40: 1679-1687.

                


                  LaHaye S, Majumdar U, Yasuhara J, Koenig SN, Matos-Nieves A, Kumar R, Garg V. Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation. Dis Model Mech. 2019 Jun 24; 12: 

                


                  Basu M, Trask AJ, Garg V. Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome. Am J Physiol Heart Circ Physiol. 2019 May 1; 316: H1141-H1143.

                


                  Matos-Nieves A, Yasuhara J, Garg V. Another Notch in the Genetic Puzzle of Tetralogy of Fallot. Circ Res. 2019 Feb 15; 124: 462-464.

                


                  Pierpont ME, Brueckner M, Chung WK, Garg V, Lacro RV, McGuire AL, Mital S, Priest JR, Pu WT, Roberts A, Ware SM, Gelb BD, Russell MW, American Heart Association Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Genomic and Precision Medicine.. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 Nov 20; 138: e653-e711.

                


                  Garg V. The Role of Lipoprotein(a) in Calcific Aortic Valve Disease: Insights From a Large-Cohort Genetic Study. JAMA Cardiol. 2018 Jan 1; 3: 24-25.

                


                  Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 

                


                  Basu M, Zhu JY, LaHaye S, Majumdar U, Jiao K, Han Z, Garg V. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease. JCI Insight. 2017 Oct 19; 2: 

View More Publications

Research

Lab(s)

Center for Cardiovascular Research

The laboratory focuses on understanding the genetic basis of congenital heart disease and the molecular pathways regulating normal and abnormal cardiac development. We have identified familial cases of congenital heart disease and used traditional linkage studies to discover novel genetic etiologies of human congenital cardiac malformations. In addition, we are interesting in understanding how these mutations disrupt normal cardiac development and are generating mouse models to gain insight into the molecular basis of congenital heart disease.

View My Publications

Publications

                  Ye S, Wang C, Xu Z, Lin H, Wan X, Yu Y, Adhicary S, Zhang JZ, Zhou Y, Liu C, Alonzo M, Bi J, Ramirez-Navarro A, Deschenes I, Ma Q, Garg V, Wu JC, Zhao MT. Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency. Circ Res. 2022 Dec 30;  

                


                  Backes CH, Hill KD, Shelton EL, Slaughter JL, Lewis TR, Weisz DE, Mah ML, Bhombal S, Smith CV, McNamara PJ, Benitz WE, Garg V. Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider. J Am Heart Assoc. 2022 Sep 6; 11: e025784.

                


                  Manivannan S, Mansfield C, Zhang X, Kodigepalli KM, Majumdar U, Garg V, Basu M. Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia. Commun Biol. 2022 Aug 15; 5: 820.

                


                  Choudhury TZ, Garg V. Molecular genetic mechanisms of congenital heart disease. Curr Opin Genet Dev. 2022 Jul 8; 75: 101949.

                


                  Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.

                


                  Gordon DM, Cunningham D, Zender G, Lawrence PJ, Penaloza JS, Lin H, Fitzgerald-Butt SM, Myers K, Duong T, Corsmeier DJ, Gaither JB, Kuck HC, Wijeratne S, Moreland B, Kelly BJ, Baylor-Johns Hopkins Center for Mendelian Genomics., Garg V, White P, McBride KL. Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery. PLoS Genet. 2022 Jun 23; 18: e1010236.

                


                  Hall B, Alonzo M, Texter K, Garg V, Zhao MT. Probing single ventricle heart defects with patient-derived induced pluripotent stem cells and emerging technologies. Birth Defects Res. 2022 Feb 24;  

                


                  Kraler S, Garg V, Akhmedov A. Calcific aortic valve disease: novel insights into nitric oxide signalling. Eur Heart J. 2022 Feb 21;  

                


                  Majumdar U, Choudhury TZ, Manivannan S, Ueyama Y, Basu M, Garg V. Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide. Front Cardiovasc Med. 2022; 9: 742850.

                


                  Bennett JS, Gordon DM, Majumdar U, Lawrence PJ, Matos-Nieves A, Myers K, Kamp AN, Leonard JC, McBride KL, White P, Garg V. Use of machine learning to classify high-risk variants of uncertain significance in lamin A/C cardiac disease. Heart Rhythm. 2021 Dec 24;  

                


                  Choudhury TZ, Majumdar U, Basu M, Garg V. Impact of maternal hyperglycemia on cardiac development: Insights from animal models. Genesis. 2021 Nov; 59: e23449.

                


                  Yasuhara J, Garg V. Genetics of congenital heart disease: a narrative review of recent advances and clinical implications. Transl Pediatr. 2021 Sep; 10: 2366-2386.

                


                  Teekakirikul P, Zhu W, Gabriel GC, Young CB, Williams K, Martin LJ, Hill JC, Richards T, Billaud M, Phillippi JA, Wang J, Wu Y, Tan T, Devine W, Lin JH, Bais AS, Klonowski J, de Bellaing AM, Saini A, Wang MX, Emerel L, Salamacha N, Wyman SK, Lee C, Sing Li H, Miron A, Zhang J, Xing J, McNamara DM, Fung E, Kirshbom P, Mahle W, Kochilas LK, He Y, Garg V, White P, McBride KL, Benson DW, Gleason TG, Mital S, Lo CW. Common deletion variants causing protocadherin-a deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease. HGG Adv. 2021 Jul 8; 2: 

                


                  Audain E, Wilsdon A, Breckpot J, Izarzugaza JMG, Fitzgerald TW, Kahlert AK, Sifrim A, Wünnemann F, Perez-Riverol Y, Abdul-Khaliq H, Bak M, Bassett AS, Benson DW, Berger F, Daehnert I, Devriendt K, Dittrich S, Daubeney PE, Garg V, Hackmann K, Hoff K, Hofmann P, Dombrowsky G, Pickardt T, Bauer U, Keavney BD, Klaassen S, Kramer HH, Marshall CR, Milewicz DM, Lemaire S, Coselli JS, Mitchell ME, Tomita-Mitchell A, Prakash SK, Stamm K, Stewart AFR, Silversides CK, Siebert R, Stiller B, Rosenfeld JA, Vater I, Postma AV, Caliebe A, Brook JD, Andelfinger G, Hurles ME, Thienpont B, Larsen LA, Hitz MP. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. PLoS Genet. 2021 Jul; 17: e1009679.

                


                  Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 

                


                  Matos-Nieves A, Manivannan S, Majumdar U, McBride KL, White P, Garg V. A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes. Front Cardiovasc Med. 2021; 8: 683074.

                


                  Lin H, McBride KL, Garg V, Zhao MT. Decoding Genetics of Congenital Heart Disease Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs). Front Cell Dev Biol. 2021; 9: 630069.

                


                  Manivannan SN, Darouich S, Masmoudi A, Gordon D, Zender G, Han Z, Fitzgerald-Butt S, White P, McBride KL, Kharrat M, Garg V. Novel frameshift variant in MYL2 reveals molecular differences between dominant and recessive forms of hypertrophic cardiomyopathy. PLoS Genet. 2020 May; 16: e1008639.

                


                  Majumdar U, Yasuhara J, Garg V. In Vivo and In Vitro Genetic Models of Congenital Heart Disease. Cold Spring Harb Perspect Biol. 2019 Dec 9;  

                


                  Bennett JS, Bernhardt M, McBride KL, Reshmi SC, Zmuda E, Kertesz NJ, Garg V, Fitzgerald-Butt S, Kamp AN. Reclassification of Variants of Uncertain Significance in Children with Inherited Arrhythmia Syndromes is Predicted by Clinical Factors. Pediatr Cardiol. 2019 Dec; 40: 1679-1687.

                


                  LaHaye S, Majumdar U, Yasuhara J, Koenig SN, Matos-Nieves A, Kumar R, Garg V. Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation. Dis Model Mech. 2019 Jun 24; 12: 

                


                  Basu M, Trask AJ, Garg V. Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome. Am J Physiol Heart Circ Physiol. 2019 May 1; 316: H1141-H1143.

                


                  Matos-Nieves A, Yasuhara J, Garg V. Another Notch in the Genetic Puzzle of Tetralogy of Fallot. Circ Res. 2019 Feb 15; 124: 462-464.

                


                  Pierpont ME, Brueckner M, Chung WK, Garg V, Lacro RV, McGuire AL, Mital S, Priest JR, Pu WT, Roberts A, Ware SM, Gelb BD, Russell MW, American Heart Association Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Genomic and Precision Medicine.. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 Nov 20; 138: e653-e711.

                


                  Garg V. The Role of Lipoprotein(a) in Calcific Aortic Valve Disease: Insights From a Large-Cohort Genetic Study. JAMA Cardiol. 2018 Jan 1; 3: 24-25.

                


                  Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 

                


                  Basu M, Zhu JY, LaHaye S, Majumdar U, Jiao K, Han Z, Garg V. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease. JCI Insight. 2017 Oct 19; 2: 

View More Publications

Lab(s)

Center for Cardiovascular Research

The laboratory focuses on understanding the genetic basis of congenital heart disease and the molecular pathways regulating normal and abnormal cardiac development. We have identified familial cases of congenital heart disease and used traditional linkage studies to discover novel genetic etiologies of human congenital cardiac malformations. In addition, we are interesting in understanding how these mutations disrupt normal cardiac development and are generating mouse models to gain insight into the molecular basis of congenital heart disease.

View My Publications

Publications

                  Ye S, Wang C, Xu Z, Lin H, Wan X, Yu Y, Adhicary S, Zhang JZ, Zhou Y, Liu C, Alonzo M, Bi J, Ramirez-Navarro A, Deschenes I, Ma Q, Garg V, Wu JC, Zhao MT. Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency. Circ Res. 2022 Dec 30;  

                


                  Backes CH, Hill KD, Shelton EL, Slaughter JL, Lewis TR, Weisz DE, Mah ML, Bhombal S, Smith CV, McNamara PJ, Benitz WE, Garg V. Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider. J Am Heart Assoc. 2022 Sep 6; 11: e025784.

                


                  Manivannan S, Mansfield C, Zhang X, Kodigepalli KM, Majumdar U, Garg V, Basu M. Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia. Commun Biol. 2022 Aug 15; 5: 820.

                


                  Choudhury TZ, Garg V. Molecular genetic mechanisms of congenital heart disease. Curr Opin Genet Dev. 2022 Jul 8; 75: 101949.

                


                  Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.

                


                  Gordon DM, Cunningham D, Zender G, Lawrence PJ, Penaloza JS, Lin H, Fitzgerald-Butt SM, Myers K, Duong T, Corsmeier DJ, Gaither JB, Kuck HC, Wijeratne S, Moreland B, Kelly BJ, Baylor-Johns Hopkins Center for Mendelian Genomics., Garg V, White P, McBride KL. Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery. PLoS Genet. 2022 Jun 23; 18: e1010236.

                


                  Hall B, Alonzo M, Texter K, Garg V, Zhao MT. Probing single ventricle heart defects with patient-derived induced pluripotent stem cells and emerging technologies. Birth Defects Res. 2022 Feb 24;  

                


                  Kraler S, Garg V, Akhmedov A. Calcific aortic valve disease: novel insights into nitric oxide signalling. Eur Heart J. 2022 Feb 21;  

                


                  Majumdar U, Choudhury TZ, Manivannan S, Ueyama Y, Basu M, Garg V. Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide. Front Cardiovasc Med. 2022; 9: 742850.

                


                  Bennett JS, Gordon DM, Majumdar U, Lawrence PJ, Matos-Nieves A, Myers K, Kamp AN, Leonard JC, McBride KL, White P, Garg V. Use of machine learning to classify high-risk variants of uncertain significance in lamin A/C cardiac disease. Heart Rhythm. 2021 Dec 24;  

                


                  Choudhury TZ, Majumdar U, Basu M, Garg V. Impact of maternal hyperglycemia on cardiac development: Insights from animal models. Genesis. 2021 Nov; 59: e23449.

                


                  Yasuhara J, Garg V. Genetics of congenital heart disease: a narrative review of recent advances and clinical implications. Transl Pediatr. 2021 Sep; 10: 2366-2386.

                


                  Teekakirikul P, Zhu W, Gabriel GC, Young CB, Williams K, Martin LJ, Hill JC, Richards T, Billaud M, Phillippi JA, Wang J, Wu Y, Tan T, Devine W, Lin JH, Bais AS, Klonowski J, de Bellaing AM, Saini A, Wang MX, Emerel L, Salamacha N, Wyman SK, Lee C, Sing Li H, Miron A, Zhang J, Xing J, McNamara DM, Fung E, Kirshbom P, Mahle W, Kochilas LK, He Y, Garg V, White P, McBride KL, Benson DW, Gleason TG, Mital S, Lo CW. Common deletion variants causing protocadherin-a deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease. HGG Adv. 2021 Jul 8; 2: 

                


                  Audain E, Wilsdon A, Breckpot J, Izarzugaza JMG, Fitzgerald TW, Kahlert AK, Sifrim A, Wünnemann F, Perez-Riverol Y, Abdul-Khaliq H, Bak M, Bassett AS, Benson DW, Berger F, Daehnert I, Devriendt K, Dittrich S, Daubeney PE, Garg V, Hackmann K, Hoff K, Hofmann P, Dombrowsky G, Pickardt T, Bauer U, Keavney BD, Klaassen S, Kramer HH, Marshall CR, Milewicz DM, Lemaire S, Coselli JS, Mitchell ME, Tomita-Mitchell A, Prakash SK, Stamm K, Stewart AFR, Silversides CK, Siebert R, Stiller B, Rosenfeld JA, Vater I, Postma AV, Caliebe A, Brook JD, Andelfinger G, Hurles ME, Thienpont B, Larsen LA, Hitz MP. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. PLoS Genet. 2021 Jul; 17: e1009679.

                


                  Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 

                


                  Matos-Nieves A, Manivannan S, Majumdar U, McBride KL, White P, Garg V. A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes. Front Cardiovasc Med. 2021; 8: 683074.

                


                  Lin H, McBride KL, Garg V, Zhao MT. Decoding Genetics of Congenital Heart Disease Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs). Front Cell Dev Biol. 2021; 9: 630069.

                


                  Manivannan SN, Darouich S, Masmoudi A, Gordon D, Zender G, Han Z, Fitzgerald-Butt S, White P, McBride KL, Kharrat M, Garg V. Novel frameshift variant in MYL2 reveals molecular differences between dominant and recessive forms of hypertrophic cardiomyopathy. PLoS Genet. 2020 May; 16: e1008639.

                


                  Majumdar U, Yasuhara J, Garg V. In Vivo and In Vitro Genetic Models of Congenital Heart Disease. Cold Spring Harb Perspect Biol. 2019 Dec 9;  

                


                  Bennett JS, Bernhardt M, McBride KL, Reshmi SC, Zmuda E, Kertesz NJ, Garg V, Fitzgerald-Butt S, Kamp AN. Reclassification of Variants of Uncertain Significance in Children with Inherited Arrhythmia Syndromes is Predicted by Clinical Factors. Pediatr Cardiol. 2019 Dec; 40: 1679-1687.

                


                  LaHaye S, Majumdar U, Yasuhara J, Koenig SN, Matos-Nieves A, Kumar R, Garg V. Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation. Dis Model Mech. 2019 Jun 24; 12: 

                


                  Basu M, Trask AJ, Garg V. Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome. Am J Physiol Heart Circ Physiol. 2019 May 1; 316: H1141-H1143.

                


                  Matos-Nieves A, Yasuhara J, Garg V. Another Notch in the Genetic Puzzle of Tetralogy of Fallot. Circ Res. 2019 Feb 15; 124: 462-464.

                


                  Pierpont ME, Brueckner M, Chung WK, Garg V, Lacro RV, McGuire AL, Mital S, Priest JR, Pu WT, Roberts A, Ware SM, Gelb BD, Russell MW, American Heart Association Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Genomic and Precision Medicine.. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 Nov 20; 138: e653-e711.

                


                  Garg V. The Role of Lipoprotein(a) in Calcific Aortic Valve Disease: Insights From a Large-Cohort Genetic Study. JAMA Cardiol. 2018 Jan 1; 3: 24-25.

                


                  Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 

                


                  Basu M, Zhu JY, LaHaye S, Majumdar U, Jiao K, Han Z, Garg V. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease. JCI Insight. 2017 Oct 19; 2: 

View More Publications

Lab(s)

Center for Cardiovascular Research

The laboratory focuses on understanding the genetic basis of congenital heart disease and the molecular pathways regulating normal and abnormal cardiac development. We have identified familial cases of congenital heart disease and used traditional linkage studies to discover novel genetic etiologies of human congenital cardiac malformations. In addition, we are interesting in understanding how these mutations disrupt normal cardiac development and are generating mouse models to gain insight into the molecular basis of congenital heart disease.

Lab(s)

Center for Cardiovascular Research

• Center for Cardiovascular Research

• View My Publications

                  Ye S, Wang C, Xu Z, Lin H, Wan X, Yu Y, Adhicary S, Zhang JZ, Zhou Y, Liu C, Alonzo M, Bi J, Ramirez-Navarro A, Deschenes I, Ma Q, Garg V, Wu JC, Zhao MT. Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency. Circ Res. 2022 Dec 30;  
  
  
  
                  Backes CH, Hill KD, Shelton EL, Slaughter JL, Lewis TR, Weisz DE, Mah ML, Bhombal S, Smith CV, McNamara PJ, Benitz WE, Garg V. Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider. J Am Heart Assoc. 2022 Sep 6; 11: e025784.
  
  
  
                  Manivannan S, Mansfield C, Zhang X, Kodigepalli KM, Majumdar U, Garg V, Basu M. Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia. Commun Biol. 2022 Aug 15; 5: 820.
  
  
  
                  Choudhury TZ, Garg V. Molecular genetic mechanisms of congenital heart disease. Curr Opin Genet Dev. 2022 Jul 8; 75: 101949.
  
  
  
                  Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.
  
  
  
                  Gordon DM, Cunningham D, Zender G, Lawrence PJ, Penaloza JS, Lin H, Fitzgerald-Butt SM, Myers K, Duong T, Corsmeier DJ, Gaither JB, Kuck HC, Wijeratne S, Moreland B, Kelly BJ, Baylor-Johns Hopkins Center for Mendelian Genomics., Garg V, White P, McBride KL. Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery. PLoS Genet. 2022 Jun 23; 18: e1010236.
  
  
  
                  Hall B, Alonzo M, Texter K, Garg V, Zhao MT. Probing single ventricle heart defects with patient-derived induced pluripotent stem cells and emerging technologies. Birth Defects Res. 2022 Feb 24;  
  
  
  
                  Kraler S, Garg V, Akhmedov A. Calcific aortic valve disease: novel insights into nitric oxide signalling. Eur Heart J. 2022 Feb 21;  
  
  
  
                  Majumdar U, Choudhury TZ, Manivannan S, Ueyama Y, Basu M, Garg V. Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide. Front Cardiovasc Med. 2022; 9: 742850.
  
  
  
                  Bennett JS, Gordon DM, Majumdar U, Lawrence PJ, Matos-Nieves A, Myers K, Kamp AN, Leonard JC, McBride KL, White P, Garg V. Use of machine learning to classify high-risk variants of uncertain significance in lamin A/C cardiac disease. Heart Rhythm. 2021 Dec 24;  
  
  
  
                  Choudhury TZ, Majumdar U, Basu M, Garg V. Impact of maternal hyperglycemia on cardiac development: Insights from animal models. Genesis. 2021 Nov; 59: e23449.
  
  
  
                  Yasuhara J, Garg V. Genetics of congenital heart disease: a narrative review of recent advances and clinical implications. Transl Pediatr. 2021 Sep; 10: 2366-2386.
  
  
  
                  Teekakirikul P, Zhu W, Gabriel GC, Young CB, Williams K, Martin LJ, Hill JC, Richards T, Billaud M, Phillippi JA, Wang J, Wu Y, Tan T, Devine W, Lin JH, Bais AS, Klonowski J, de Bellaing AM, Saini A, Wang MX, Emerel L, Salamacha N, Wyman SK, Lee C, Sing Li H, Miron A, Zhang J, Xing J, McNamara DM, Fung E, Kirshbom P, Mahle W, Kochilas LK, He Y, Garg V, White P, McBride KL, Benson DW, Gleason TG, Mital S, Lo CW. Common deletion variants causing protocadherin-a deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease. HGG Adv. 2021 Jul 8; 2: 
  
  
  
                  Audain E, Wilsdon A, Breckpot J, Izarzugaza JMG, Fitzgerald TW, Kahlert AK, Sifrim A, Wünnemann F, Perez-Riverol Y, Abdul-Khaliq H, Bak M, Bassett AS, Benson DW, Berger F, Daehnert I, Devriendt K, Dittrich S, Daubeney PE, Garg V, Hackmann K, Hoff K, Hofmann P, Dombrowsky G, Pickardt T, Bauer U, Keavney BD, Klaassen S, Kramer HH, Marshall CR, Milewicz DM, Lemaire S, Coselli JS, Mitchell ME, Tomita-Mitchell A, Prakash SK, Stamm K, Stewart AFR, Silversides CK, Siebert R, Stiller B, Rosenfeld JA, Vater I, Postma AV, Caliebe A, Brook JD, Andelfinger G, Hurles ME, Thienpont B, Larsen LA, Hitz MP. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. PLoS Genet. 2021 Jul; 17: e1009679.
  
  
  
                  Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 
  
  
  
                  Matos-Nieves A, Manivannan S, Majumdar U, McBride KL, White P, Garg V. A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes. Front Cardiovasc Med. 2021; 8: 683074.
  
  
  
                  Lin H, McBride KL, Garg V, Zhao MT. Decoding Genetics of Congenital Heart Disease Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs). Front Cell Dev Biol. 2021; 9: 630069.
  
  
  
                  Manivannan SN, Darouich S, Masmoudi A, Gordon D, Zender G, Han Z, Fitzgerald-Butt S, White P, McBride KL, Kharrat M, Garg V. Novel frameshift variant in MYL2 reveals molecular differences between dominant and recessive forms of hypertrophic cardiomyopathy. PLoS Genet. 2020 May; 16: e1008639.
  
  
  
                  Majumdar U, Yasuhara J, Garg V. In Vivo and In Vitro Genetic Models of Congenital Heart Disease. Cold Spring Harb Perspect Biol. 2019 Dec 9;  
  
  
  
                  Bennett JS, Bernhardt M, McBride KL, Reshmi SC, Zmuda E, Kertesz NJ, Garg V, Fitzgerald-Butt S, Kamp AN. Reclassification of Variants of Uncertain Significance in Children with Inherited Arrhythmia Syndromes is Predicted by Clinical Factors. Pediatr Cardiol. 2019 Dec; 40: 1679-1687.
  
  
  
                  LaHaye S, Majumdar U, Yasuhara J, Koenig SN, Matos-Nieves A, Kumar R, Garg V. Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation. Dis Model Mech. 2019 Jun 24; 12: 
  
  
  
                  Basu M, Trask AJ, Garg V. Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome. Am J Physiol Heart Circ Physiol. 2019 May 1; 316: H1141-H1143.
  
  
  
                  Matos-Nieves A, Yasuhara J, Garg V. Another Notch in the Genetic Puzzle of Tetralogy of Fallot. Circ Res. 2019 Feb 15; 124: 462-464.
  
  
  
                  Pierpont ME, Brueckner M, Chung WK, Garg V, Lacro RV, McGuire AL, Mital S, Priest JR, Pu WT, Roberts A, Ware SM, Gelb BD, Russell MW, American Heart Association Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Genomic and Precision Medicine.. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 Nov 20; 138: e653-e711.
  
  
  
                  Garg V. The Role of Lipoprotein(a) in Calcific Aortic Valve Disease: Insights From a Large-Cohort Genetic Study. JAMA Cardiol. 2018 Jan 1; 3: 24-25.
  
  
  
                  Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 
  
  
  
                  Basu M, Zhu JY, LaHaye S, Majumdar U, Jiao K, Han Z, Garg V. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease. JCI Insight. 2017 Oct 19; 2: 
  
  

View More Publications

• Ye S, Wang C, Xu Z, Lin H, Wan X, Yu Y, Adhicary S, Zhang JZ, Zhou Y, Liu C, Alonzo M, Bi J, Ramirez-Navarro A, Deschenes I, Ma Q, Garg V, Wu JC, Zhao MT. Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency. Circ Res. 2022 Dec 30;
• Backes CH, Hill KD, Shelton EL, Slaughter JL, Lewis TR, Weisz DE, Mah ML, Bhombal S, Smith CV, McNamara PJ, Benitz WE, Garg V. Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider. J Am Heart Assoc. 2022 Sep 6; 11: e025784.
• Manivannan S, Mansfield C, Zhang X, Kodigepalli KM, Majumdar U, Garg V, Basu M. Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia. Commun Biol. 2022 Aug 15; 5: 820.
• Choudhury TZ, Garg V. Molecular genetic mechanisms of congenital heart disease. Curr Opin Genet Dev. 2022 Jul 8; 75: 101949.
• Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.
• Gordon DM, Cunningham D, Zender G, Lawrence PJ, Penaloza JS, Lin H, Fitzgerald-Butt SM, Myers K, Duong T, Corsmeier DJ, Gaither JB, Kuck HC, Wijeratne S, Moreland B, Kelly BJ, Baylor-Johns Hopkins Center for Mendelian Genomics., Garg V, White P, McBride KL. Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery. PLoS Genet. 2022 Jun 23; 18: e1010236.
• Hall B, Alonzo M, Texter K, Garg V, Zhao MT. Probing single ventricle heart defects with patient-derived induced pluripotent stem cells and emerging technologies. Birth Defects Res. 2022 Feb 24;
• Kraler S, Garg V, Akhmedov A. Calcific aortic valve disease: novel insights into nitric oxide signalling. Eur Heart J. 2022 Feb 21;
• Majumdar U, Choudhury TZ, Manivannan S, Ueyama Y, Basu M, Garg V. Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide. Front Cardiovasc Med. 2022; 9: 742850.
• Bennett JS, Gordon DM, Majumdar U, Lawrence PJ, Matos-Nieves A, Myers K, Kamp AN, Leonard JC, McBride KL, White P, Garg V. Use of machine learning to classify high-risk variants of uncertain significance in lamin A/C cardiac disease. Heart Rhythm. 2021 Dec 24;
• Choudhury TZ, Majumdar U, Basu M, Garg V. Impact of maternal hyperglycemia on cardiac development: Insights from animal models. Genesis. 2021 Nov; 59: e23449.
• Yasuhara J, Garg V. Genetics of congenital heart disease: a narrative review of recent advances and clinical implications. Transl Pediatr. 2021 Sep; 10: 2366-2386.
• Teekakirikul P, Zhu W, Gabriel GC, Young CB, Williams K, Martin LJ, Hill JC, Richards T, Billaud M, Phillippi JA, Wang J, Wu Y, Tan T, Devine W, Lin JH, Bais AS, Klonowski J, de Bellaing AM, Saini A, Wang MX, Emerel L, Salamacha N, Wyman SK, Lee C, Sing Li H, Miron A, Zhang J, Xing J, McNamara DM, Fung E, Kirshbom P, Mahle W, Kochilas LK, He Y, Garg V, White P, McBride KL, Benson DW, Gleason TG, Mital S, Lo CW. Common deletion variants causing protocadherin-a deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease. HGG Adv. 2021 Jul 8; 2:
• Audain E, Wilsdon A, Breckpot J, Izarzugaza JMG, Fitzgerald TW, Kahlert AK, Sifrim A, Wünnemann F, Perez-Riverol Y, Abdul-Khaliq H, Bak M, Bassett AS, Benson DW, Berger F, Daehnert I, Devriendt K, Dittrich S, Daubeney PE, Garg V, Hackmann K, Hoff K, Hofmann P, Dombrowsky G, Pickardt T, Bauer U, Keavney BD, Klaassen S, Kramer HH, Marshall CR, Milewicz DM, Lemaire S, Coselli JS, Mitchell ME, Tomita-Mitchell A, Prakash SK, Stamm K, Stewart AFR, Silversides CK, Siebert R, Stiller B, Rosenfeld JA, Vater I, Postma AV, Caliebe A, Brook JD, Andelfinger G, Hurles ME, Thienpont B, Larsen LA, Hitz MP. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. PLoS Genet. 2021 Jul; 17: e1009679.
• Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7:
• Matos-Nieves A, Manivannan S, Majumdar U, McBride KL, White P, Garg V. A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes. Front Cardiovasc Med. 2021; 8: 683074.
• Lin H, McBride KL, Garg V, Zhao MT. Decoding Genetics of Congenital Heart Disease Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs). Front Cell Dev Biol. 2021; 9: 630069.
• Manivannan SN, Darouich S, Masmoudi A, Gordon D, Zender G, Han Z, Fitzgerald-Butt S, White P, McBride KL, Kharrat M, Garg V. Novel frameshift variant in MYL2 reveals molecular differences between dominant and recessive forms of hypertrophic cardiomyopathy. PLoS Genet. 2020 May; 16: e1008639.
• Majumdar U, Yasuhara J, Garg V. In Vivo and In Vitro Genetic Models of Congenital Heart Disease. Cold Spring Harb Perspect Biol. 2019 Dec 9;
• Bennett JS, Bernhardt M, McBride KL, Reshmi SC, Zmuda E, Kertesz NJ, Garg V, Fitzgerald-Butt S, Kamp AN. Reclassification of Variants of Uncertain Significance in Children with Inherited Arrhythmia Syndromes is Predicted by Clinical Factors. Pediatr Cardiol. 2019 Dec; 40: 1679-1687.
• LaHaye S, Majumdar U, Yasuhara J, Koenig SN, Matos-Nieves A, Kumar R, Garg V. Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation. Dis Model Mech. 2019 Jun 24; 12:
• Basu M, Trask AJ, Garg V. Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome. Am J Physiol Heart Circ Physiol. 2019 May 1; 316: H1141-H1143.
• Matos-Nieves A, Yasuhara J, Garg V. Another Notch in the Genetic Puzzle of Tetralogy of Fallot. Circ Res. 2019 Feb 15; 124: 462-464.
• Pierpont ME, Brueckner M, Chung WK, Garg V, Lacro RV, McGuire AL, Mital S, Priest JR, Pu WT, Roberts A, Ware SM, Gelb BD, Russell MW, American Heart Association Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; and Council on Genomic and Precision Medicine.. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association. Circulation. 2018 Nov 20; 138: e653-e711.
• Garg V. The Role of Lipoprotein(a) in Calcific Aortic Valve Disease: Insights From a Large-Cohort Genetic Study. JAMA Cardiol. 2018 Jan 1; 3: 24-25.
• Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2:
• Basu M, Zhu JY, LaHaye S, Majumdar U, Jiao K, Han Z, Garg V. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease. JCI Insight. 2017 Oct 19; 2:

Education

Date of Appointment at Nationwide Children’s Hospital: 07/31/2009

Board Certifications

Pediatric Cardiology

Fellowship

University of Texas Southwestern Medical Center

Date Completed: 06/30/2002

Fellowship

Children’s Medical Center of Dallas

Date Completed: 06/30/2000

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/1997

Medical School

Jefferson Medical College

Date Completed: 06/10/1994

Education

Date of Appointment at Nationwide Children’s Hospital: 07/31/2009

Board Certifications

Pediatric Cardiology

Fellowship

University of Texas Southwestern Medical Center

Date Completed: 06/30/2002

Fellowship

Children’s Medical Center of Dallas

Date Completed: 06/30/2000

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/1997

Medical School

Jefferson Medical College

Date Completed: 06/10/1994

Education

Date of Appointment at Nationwide Children’s Hospital: 07/31/2009

Board Certifications

Pediatric Cardiology

Fellowship

University of Texas Southwestern Medical Center

Date Completed: 06/30/2002

Fellowship

Children’s Medical Center of Dallas

Date Completed: 06/30/2000

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/1997

Medical School

Jefferson Medical College

Date Completed: 06/10/1994

Date of Appointment at Nationwide Children’s Hospital: 07/31/2009

Board Certifications

Pediatric Cardiology

Fellowship

University of Texas Southwestern Medical Center

Date Completed: 06/30/2002

Fellowship

Children’s Medical Center of Dallas

Date Completed: 06/30/2000

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/1997

Medical School

Jefferson Medical College

Date Completed: 06/10/1994

Date of Appointment at Nationwide Children’s Hospital: 07/31/2009

Board Certifications

Pediatric Cardiology

Fellowship

University of Texas Southwestern Medical Center

Date Completed: 06/30/2002

Fellowship

Children’s Medical Center of Dallas

Date Completed: 06/30/2000

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/1997

Medical School

Jefferson Medical College

Date Completed: 06/10/1994

• Pediatric Cardiology

Professional Experience

2016 - Present Department of Pediatrics, The Ohio State University, Professor2015 - Present Center for Cardiovascular Research, Director2009 - Present The Heart Center Center for Cardiovascular Research, Nationwide Children’s Hospital, Director of Translational Research2009 - Present Department of Molecular Genetics, The Ohio State University, Professor2009 - 2016 Department of Molecular Genetics, The Ohio State University, Associate Professor2009 - 2016 Department of Pediatrics, The Ohio State University, Associate Professor2005 - 2009 Department of Molecular Biology, University of Texas Southwestern Medical Center, Assistant Professor2005 - 2009 McDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Assistant Professor2002 - 2009 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Professor2002 - 2009 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Professor2000 - 2002 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Instructor1994 - 1997 Department of Pediatrics, The Ohio State University College of Medicine, Clinical Instructor

Professional Experience

2016 - Present Department of Pediatrics, The Ohio State University, Professor2015 - Present Center for Cardiovascular Research, Director2009 - Present The Heart Center Center for Cardiovascular Research, Nationwide Children’s Hospital, Director of Translational Research2009 - Present Department of Molecular Genetics, The Ohio State University, Professor2009 - 2016 Department of Molecular Genetics, The Ohio State University, Associate Professor2009 - 2016 Department of Pediatrics, The Ohio State University, Associate Professor2005 - 2009 Department of Molecular Biology, University of Texas Southwestern Medical Center, Assistant Professor2005 - 2009 McDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Assistant Professor2002 - 2009 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Professor2002 - 2009 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Professor2000 - 2002 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Instructor1994 - 1997 Department of Pediatrics, The Ohio State University College of Medicine, Clinical Instructor

Professional Experience

2016 - Present Department of Pediatrics, The Ohio State University, Professor2015 - Present Center for Cardiovascular Research, Director2009 - Present The Heart Center Center for Cardiovascular Research, Nationwide Children’s Hospital, Director of Translational Research2009 - Present Department of Molecular Genetics, The Ohio State University, Professor2009 - 2016 Department of Molecular Genetics, The Ohio State University, Associate Professor2009 - 2016 Department of Pediatrics, The Ohio State University, Associate Professor2005 - 2009 Department of Molecular Biology, University of Texas Southwestern Medical Center, Assistant Professor2005 - 2009 McDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Assistant Professor2002 - 2009 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Professor2002 - 2009 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Professor2000 - 2002 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Instructor1994 - 1997 Department of Pediatrics, The Ohio State University College of Medicine, Clinical Instructor

2016 - Present Department of Pediatrics, The Ohio State University, Professor2015 - Present Center for Cardiovascular Research, Director2009 - Present The Heart Center Center for Cardiovascular Research, Nationwide Children’s Hospital, Director of Translational Research2009 - Present Department of Molecular Genetics, The Ohio State University, Professor2009 - 2016 Department of Molecular Genetics, The Ohio State University, Associate Professor2009 - 2016 Department of Pediatrics, The Ohio State University, Associate Professor2005 - 2009 Department of Molecular Biology, University of Texas Southwestern Medical Center, Assistant Professor2005 - 2009 McDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Assistant Professor2002 - 2009 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Professor2002 - 2009 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Professor2000 - 2002 Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Assistant Instructor1994 - 1997 Department of Pediatrics, The Ohio State University College of Medicine, Clinical Instructor

2016 - Present Department of Pediatrics, The Ohio State University, Professor

Contact Information

Pediatrics

Call us at: (614) 722-2530

Fax us at: (614) 722-2549

                    Cardiology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pediatrics

Call us at: (614) 722-2530

Fax us at: (614) 722-2549

                    Cardiology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pediatrics

Call us at: (614) 722-2530

Fax us at: (614) 722-2549

                    Cardiology700 Children's DrColumbus, OH 43205 (map)

Pediatrics

Call us at: (614) 722-2530

Fax us at: (614) 722-2549

                    Cardiology700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-2530

Fax us at: (614) 722-2549

                    Cardiology700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-2530

Fax us at: (614) 722-2549

                    Cardiology700 Children's DrColumbus, OH 43205 (map)

• Call us at:
• (614) 722-2530
• Fax us at:
• (614) 722-2549
• Cardiology700 Children’s DrColumbus, OH 43205 (map)