Contact Information
Call us at: (614) 355-3147
Email Tracy A Bedrosian, PhD
Institute for Genomic Medicine575 Children’s CrossroadColumbus, OH 43215 (map)
Learn more about Tracy A Bedrosian
Biography
Tracy Bedrosian, PhD, is a Principal Investigator in the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. She leads a translational neuroscience laboratory that aims to identify genetic and molecular mechanisms of neurodevelopmental disease. Dr. Bedrosian is also an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Bedrosian studied Neuroscience at the University of Michigan where she worked as a research assistant in Dr. Huda Akil’s lab investigating genetic and environmental contributions to neuropsychiatric disease. She earned her Ph.D. in Neuroscience as an NDSEG graduate fellow in Dr. Randy Nelson’s lab at The Ohio State University, where she established the effects of circadian rhythm disruption on mood and brain plasticity. Dr. Bedrosian completed post-doctoral training as a Ruth L. Kirschstein NRSA postdoctoral fellow and NARSAD Young Investigator at the Salk Institute under the mentorship of Dr. Fred Gage. In this role, she became deeply interested in somatic mosaicism and neurodevelopment. Dr. Bedrosian furthered her training in genomics and bioinformatics as an NHGRI K01 Career Development awardee under the mentorship of Dr. Richard Wilson at Nationwide Children’s Hospital where she developed novel single-cell sequencing approaches and analyses for the detection of brain somatic variation.
Awards, Honors & Organizations
Research Scientist Development Award (K01), NHGRI, 2020 NARSAD Young Investigator Award, BBRF, 2017 National Research Service Award (F32), NIMH, 2014 National Defense Science and Engineering Graduate (NDSEG) Fellowship, DoD, 2010
Research
Our team takes a translational approach to study mechanisms of neurodevelopmental diseases, such as brain malformation, epilepsy, and autism. We combine characterization of patient brain specimens with functional modeling in patient-derived cell lines and transgenic mice, with the goal of generating knowledge that will lead to best outcomes for patients. Publications
Townsend SE, Westfall JJ, Navarro JB, Koboldt DC, Mardis ER, Miller KE, Bedrosian TA. Single-nuclei transcriptomics enable detection of somatic variants in patient brain tissue. Sci Rep. 2023 Jan 11; 13: 527.
Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.
Fair SR, Schwind W, Julian D, Biel A, Guo G, Rutherford R, Ramadesikan S, Westfall J, Miller KE, Kararoudi MN, Hickey SE, Mosher TM, McBride KL, Neinast R, Fitch J, Lee D, White P, Wilson RK, Bedrosian TA, Koboldt DC, Hester ME. Cerebral organoids containing an AUTS2 missense variant model microcephaly. Brain. 2022 Jul 8;
Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;
Tan K, Kim ME, Song HW, Skarbrevik D, Babajanian E, Bedrosian TA, Gage FH, Wilkinson MF. The Rhox gene cluster suppresses germline LINE1 transposition. Proc Natl Acad Sci U S A. 2021 Jun 8; 118:
Koboldt DC, Miller KE, Miller AR, Bush JM, McGrath S, Leraas K, Crist E, Fair S, Schwind W, Wijeratne S, Fitch J, Leonard J, Shaikhouni A, Hester ME, Magrini V, Ho ML, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Bedrosian TA. PTEN somatic mutations contribute to spectrum of cerebral overgrowth. Brain. 2021 May 28;
Bedrosian TA, Houtman J, Eguiguren JS, Ghassemzadeh S, Rund N, Novaresi NM, Hu L, Parylak SL, Denli AM, Randolph-Moore L, Namba T, Gage FH, Toda T. Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. EMBO J. 2021 Feb 1; 40: e105819.
Fair SR, Julian D, Hartlaub AM, Pusuluri ST, Malik G, Summerfied TL, Zhao G, Hester AB, Ackerman WE 4th, Hollingsworth EW, Ali M, McElroy CA, Buhimschi IA, Imitola J, Maitre NL, Bedrosian TA, Hester ME. Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development. Stem Cell Reports. 2020 Oct 13; 15: 855-868.
Miller KE, Koboldt DC, Schieffer KM, Bedrosian TA, Crist E, Sheline A, Leraas K, Magrini V, Zhong H, Brennan P, Bush J, Fitch J, Bir N, Miller AR, Cottrell CE, Leonard J, Pindrik JA, Rusin JA, Shah SH, White P, Wilson RK, Mardis ER, Pierson CR, Ostendorf AP. Somatic SLC35A2 mosaicism correlates with clinical findings in epilepsy brain tissue. Neurol Genet. 2020 Aug; 6: e460.
Bedrosian TA, Quayle C, Novaresi N, Gage FH. Early life experience drives structural variation of neural genomes in mice. Science. 2018 Mar 23; 359: 1395-1399.
View More Publications
Education
Date of Appointment at Nationwide Children’s Hospital: 08/03/2020
Graduate School
The Ohio State University
Date Completed: 05/01/2013
Undergraduate School
University of Michigan
Date Completed: 05/01/2008
Contact Information
Institute for Genomic Medicine
Call us at: (614) 355-3147
Email Tracy A Bedrosian
575 Children's CrossroadColumbus, OH 43215 (map)
Contact Information
Call us at: (614) 355-3147
Email Tracy A Bedrosian, PhD
Institute for Genomic Medicine575 Children’s CrossroadColumbus, OH 43215 (map)
Learn more about Tracy A Bedrosian
Biography
Tracy Bedrosian, PhD, is a Principal Investigator in the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. She leads a translational neuroscience laboratory that aims to identify genetic and molecular mechanisms of neurodevelopmental disease. Dr. Bedrosian is also an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Bedrosian studied Neuroscience at the University of Michigan where she worked as a research assistant in Dr. Huda Akil’s lab investigating genetic and environmental contributions to neuropsychiatric disease. She earned her Ph.D. in Neuroscience as an NDSEG graduate fellow in Dr. Randy Nelson’s lab at The Ohio State University, where she established the effects of circadian rhythm disruption on mood and brain plasticity. Dr. Bedrosian completed post-doctoral training as a Ruth L. Kirschstein NRSA postdoctoral fellow and NARSAD Young Investigator at the Salk Institute under the mentorship of Dr. Fred Gage. In this role, she became deeply interested in somatic mosaicism and neurodevelopment. Dr. Bedrosian furthered her training in genomics and bioinformatics as an NHGRI K01 Career Development awardee under the mentorship of Dr. Richard Wilson at Nationwide Children’s Hospital where she developed novel single-cell sequencing approaches and analyses for the detection of brain somatic variation.
Awards, Honors & Organizations
Research Scientist Development Award (K01), NHGRI, 2020 NARSAD Young Investigator Award, BBRF, 2017 National Research Service Award (F32), NIMH, 2014 National Defense Science and Engineering Graduate (NDSEG) Fellowship, DoD, 2010
Research
Our team takes a translational approach to study mechanisms of neurodevelopmental diseases, such as brain malformation, epilepsy, and autism. We combine characterization of patient brain specimens with functional modeling in patient-derived cell lines and transgenic mice, with the goal of generating knowledge that will lead to best outcomes for patients. Publications
Townsend SE, Westfall JJ, Navarro JB, Koboldt DC, Mardis ER, Miller KE, Bedrosian TA. Single-nuclei transcriptomics enable detection of somatic variants in patient brain tissue. Sci Rep. 2023 Jan 11; 13: 527.
Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.
Fair SR, Schwind W, Julian D, Biel A, Guo G, Rutherford R, Ramadesikan S, Westfall J, Miller KE, Kararoudi MN, Hickey SE, Mosher TM, McBride KL, Neinast R, Fitch J, Lee D, White P, Wilson RK, Bedrosian TA, Koboldt DC, Hester ME. Cerebral organoids containing an AUTS2 missense variant model microcephaly. Brain. 2022 Jul 8;
Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;
Tan K, Kim ME, Song HW, Skarbrevik D, Babajanian E, Bedrosian TA, Gage FH, Wilkinson MF. The Rhox gene cluster suppresses germline LINE1 transposition. Proc Natl Acad Sci U S A. 2021 Jun 8; 118:
Koboldt DC, Miller KE, Miller AR, Bush JM, McGrath S, Leraas K, Crist E, Fair S, Schwind W, Wijeratne S, Fitch J, Leonard J, Shaikhouni A, Hester ME, Magrini V, Ho ML, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Bedrosian TA. PTEN somatic mutations contribute to spectrum of cerebral overgrowth. Brain. 2021 May 28;
Bedrosian TA, Houtman J, Eguiguren JS, Ghassemzadeh S, Rund N, Novaresi NM, Hu L, Parylak SL, Denli AM, Randolph-Moore L, Namba T, Gage FH, Toda T. Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. EMBO J. 2021 Feb 1; 40: e105819.
Fair SR, Julian D, Hartlaub AM, Pusuluri ST, Malik G, Summerfied TL, Zhao G, Hester AB, Ackerman WE 4th, Hollingsworth EW, Ali M, McElroy CA, Buhimschi IA, Imitola J, Maitre NL, Bedrosian TA, Hester ME. Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development. Stem Cell Reports. 2020 Oct 13; 15: 855-868.
Miller KE, Koboldt DC, Schieffer KM, Bedrosian TA, Crist E, Sheline A, Leraas K, Magrini V, Zhong H, Brennan P, Bush J, Fitch J, Bir N, Miller AR, Cottrell CE, Leonard J, Pindrik JA, Rusin JA, Shah SH, White P, Wilson RK, Mardis ER, Pierson CR, Ostendorf AP. Somatic SLC35A2 mosaicism correlates with clinical findings in epilepsy brain tissue. Neurol Genet. 2020 Aug; 6: e460.
Bedrosian TA, Quayle C, Novaresi N, Gage FH. Early life experience drives structural variation of neural genomes in mice. Science. 2018 Mar 23; 359: 1395-1399.
View More Publications
Education
Date of Appointment at Nationwide Children’s Hospital: 08/03/2020
Graduate School
The Ohio State University
Date Completed: 05/01/2013
Undergraduate School
University of Michigan
Date Completed: 05/01/2008
Contact Information
Institute for Genomic Medicine
Call us at: (614) 355-3147
Email Tracy A Bedrosian
575 Children's CrossroadColumbus, OH 43215 (map)
Contact Information
Call us at: (614) 355-3147
Email Tracy A Bedrosian, PhD
Institute for Genomic Medicine575 Children’s CrossroadColumbus, OH 43215 (map)
Learn more about Tracy A Bedrosian
Contact Information
- Call us at:
- (614) 355-3147
- Email Tracy A Bedrosian, PhD
- Institute for Genomic Medicine575 Children’s CrossroadColumbus, OH 43215 (map)
Learn more about Tracy A Bedrosian
Biography
Tracy Bedrosian, PhD, is a Principal Investigator in the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. She leads a translational neuroscience laboratory that aims to identify genetic and molecular mechanisms of neurodevelopmental disease. Dr. Bedrosian is also an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Bedrosian studied Neuroscience at the University of Michigan where she worked as a research assistant in Dr. Huda Akil’s lab investigating genetic and environmental contributions to neuropsychiatric disease. She earned her Ph.D. in Neuroscience as an NDSEG graduate fellow in Dr. Randy Nelson’s lab at The Ohio State University, where she established the effects of circadian rhythm disruption on mood and brain plasticity. Dr. Bedrosian completed post-doctoral training as a Ruth L. Kirschstein NRSA postdoctoral fellow and NARSAD Young Investigator at the Salk Institute under the mentorship of Dr. Fred Gage. In this role, she became deeply interested in somatic mosaicism and neurodevelopment. Dr. Bedrosian furthered her training in genomics and bioinformatics as an NHGRI K01 Career Development awardee under the mentorship of Dr. Richard Wilson at Nationwide Children’s Hospital where she developed novel single-cell sequencing approaches and analyses for the detection of brain somatic variation.
Biography
Tracy Bedrosian, PhD, is a Principal Investigator in the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. She leads a translational neuroscience laboratory that aims to identify genetic and molecular mechanisms of neurodevelopmental disease. Dr. Bedrosian is also an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Bedrosian studied Neuroscience at the University of Michigan where she worked as a research assistant in Dr. Huda Akil’s lab investigating genetic and environmental contributions to neuropsychiatric disease. She earned her Ph.D. in Neuroscience as an NDSEG graduate fellow in Dr. Randy Nelson’s lab at The Ohio State University, where she established the effects of circadian rhythm disruption on mood and brain plasticity. Dr. Bedrosian completed post-doctoral training as a Ruth L. Kirschstein NRSA postdoctoral fellow and NARSAD Young Investigator at the Salk Institute under the mentorship of Dr. Fred Gage. In this role, she became deeply interested in somatic mosaicism and neurodevelopment. Dr. Bedrosian furthered her training in genomics and bioinformatics as an NHGRI K01 Career Development awardee under the mentorship of Dr. Richard Wilson at Nationwide Children’s Hospital where she developed novel single-cell sequencing approaches and analyses for the detection of brain somatic variation.
Biography
Tracy Bedrosian, PhD, is a Principal Investigator in the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. She leads a translational neuroscience laboratory that aims to identify genetic and molecular mechanisms of neurodevelopmental disease. Dr. Bedrosian is also an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Bedrosian studied Neuroscience at the University of Michigan where she worked as a research assistant in Dr. Huda Akil’s lab investigating genetic and environmental contributions to neuropsychiatric disease. She earned her Ph.D. in Neuroscience as an NDSEG graduate fellow in Dr. Randy Nelson’s lab at The Ohio State University, where she established the effects of circadian rhythm disruption on mood and brain plasticity. Dr. Bedrosian completed post-doctoral training as a Ruth L. Kirschstein NRSA postdoctoral fellow and NARSAD Young Investigator at the Salk Institute under the mentorship of Dr. Fred Gage. In this role, she became deeply interested in somatic mosaicism and neurodevelopment. Dr. Bedrosian furthered her training in genomics and bioinformatics as an NHGRI K01 Career Development awardee under the mentorship of Dr. Richard Wilson at Nationwide Children’s Hospital where she developed novel single-cell sequencing approaches and analyses for the detection of brain somatic variation.
Tracy Bedrosian, PhD, is a Principal Investigator in the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. She leads a translational neuroscience laboratory that aims to identify genetic and molecular mechanisms of neurodevelopmental disease. Dr. Bedrosian is also an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Bedrosian studied Neuroscience at the University of Michigan where she worked as a research assistant in Dr. Huda Akil’s lab investigating genetic and environmental contributions to neuropsychiatric disease. She earned her Ph.D. in Neuroscience as an NDSEG graduate fellow in Dr. Randy Nelson’s lab at The Ohio State University, where she established the effects of circadian rhythm disruption on mood and brain plasticity. Dr. Bedrosian completed post-doctoral training as a Ruth L. Kirschstein NRSA postdoctoral fellow and NARSAD Young Investigator at the Salk Institute under the mentorship of Dr. Fred Gage. In this role, she became deeply interested in somatic mosaicism and neurodevelopment. Dr. Bedrosian furthered her training in genomics and bioinformatics as an NHGRI K01 Career Development awardee under the mentorship of Dr. Richard Wilson at Nationwide Children’s Hospital where she developed novel single-cell sequencing approaches and analyses for the detection of brain somatic variation.
Tracy Bedrosian, PhD, is a Principal Investigator in the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. She leads a translational neuroscience laboratory that aims to identify genetic and molecular mechanisms of neurodevelopmental disease. Dr. Bedrosian is also an Assistant Professor of Pediatrics at The Ohio State University College of Medicine.
Dr. Bedrosian studied Neuroscience at the University of Michigan where she worked as a research assistant in Dr. Huda Akil’s lab investigating genetic and environmental contributions to neuropsychiatric disease. She earned her Ph.D. in Neuroscience as an NDSEG graduate fellow in Dr. Randy Nelson’s lab at The Ohio State University, where she established the effects of circadian rhythm disruption on mood and brain plasticity. Dr. Bedrosian completed post-doctoral training as a Ruth L. Kirschstein NRSA postdoctoral fellow and NARSAD Young Investigator at the Salk Institute under the mentorship of Dr. Fred Gage. In this role, she became deeply interested in somatic mosaicism and neurodevelopment. Dr. Bedrosian furthered her training in genomics and bioinformatics as an NHGRI K01 Career Development awardee under the mentorship of Dr. Richard Wilson at Nationwide Children’s Hospital where she developed novel single-cell sequencing approaches and analyses for the detection of brain somatic variation.
Awards, Honors & Organizations
Research Scientist Development Award (K01), NHGRI, 2020 NARSAD Young Investigator Award, BBRF, 2017 National Research Service Award (F32), NIMH, 2014 National Defense Science and Engineering Graduate (NDSEG) Fellowship, DoD, 2010
Awards, Honors & Organizations
Research Scientist Development Award (K01), NHGRI, 2020 NARSAD Young Investigator Award, BBRF, 2017 National Research Service Award (F32), NIMH, 2014 National Defense Science and Engineering Graduate (NDSEG) Fellowship, DoD, 2010
Awards, Honors & Organizations
Research Scientist Development Award (K01), NHGRI, 2020 NARSAD Young Investigator Award, BBRF, 2017 National Research Service Award (F32), NIMH, 2014 National Defense Science and Engineering Graduate (NDSEG) Fellowship, DoD, 2010
Research Scientist Development Award (K01), NHGRI, 2020 NARSAD Young Investigator Award, BBRF, 2017 National Research Service Award (F32), NIMH, 2014 National Defense Science and Engineering Graduate (NDSEG) Fellowship, DoD, 2010
- Research Scientist Development Award (K01), NHGRI, 2020
- NARSAD Young Investigator Award, BBRF, 2017
- National Research Service Award (F32), NIMH, 2014
- National Defense Science and Engineering Graduate (NDSEG) Fellowship, DoD, 2010
Research
Our team takes a translational approach to study mechanisms of neurodevelopmental diseases, such as brain malformation, epilepsy, and autism. We combine characterization of patient brain specimens with functional modeling in patient-derived cell lines and transgenic mice, with the goal of generating knowledge that will lead to best outcomes for patients. Publications
Townsend SE, Westfall JJ, Navarro JB, Koboldt DC, Mardis ER, Miller KE, Bedrosian TA. Single-nuclei transcriptomics enable detection of somatic variants in patient brain tissue. Sci Rep. 2023 Jan 11; 13: 527.
Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.
Fair SR, Schwind W, Julian D, Biel A, Guo G, Rutherford R, Ramadesikan S, Westfall J, Miller KE, Kararoudi MN, Hickey SE, Mosher TM, McBride KL, Neinast R, Fitch J, Lee D, White P, Wilson RK, Bedrosian TA, Koboldt DC, Hester ME. Cerebral organoids containing an AUTS2 missense variant model microcephaly. Brain. 2022 Jul 8;
Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;
Tan K, Kim ME, Song HW, Skarbrevik D, Babajanian E, Bedrosian TA, Gage FH, Wilkinson MF. The Rhox gene cluster suppresses germline LINE1 transposition. Proc Natl Acad Sci U S A. 2021 Jun 8; 118:
Koboldt DC, Miller KE, Miller AR, Bush JM, McGrath S, Leraas K, Crist E, Fair S, Schwind W, Wijeratne S, Fitch J, Leonard J, Shaikhouni A, Hester ME, Magrini V, Ho ML, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Bedrosian TA. PTEN somatic mutations contribute to spectrum of cerebral overgrowth. Brain. 2021 May 28;
Bedrosian TA, Houtman J, Eguiguren JS, Ghassemzadeh S, Rund N, Novaresi NM, Hu L, Parylak SL, Denli AM, Randolph-Moore L, Namba T, Gage FH, Toda T. Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. EMBO J. 2021 Feb 1; 40: e105819.
Fair SR, Julian D, Hartlaub AM, Pusuluri ST, Malik G, Summerfied TL, Zhao G, Hester AB, Ackerman WE 4th, Hollingsworth EW, Ali M, McElroy CA, Buhimschi IA, Imitola J, Maitre NL, Bedrosian TA, Hester ME. Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development. Stem Cell Reports. 2020 Oct 13; 15: 855-868.
Miller KE, Koboldt DC, Schieffer KM, Bedrosian TA, Crist E, Sheline A, Leraas K, Magrini V, Zhong H, Brennan P, Bush J, Fitch J, Bir N, Miller AR, Cottrell CE, Leonard J, Pindrik JA, Rusin JA, Shah SH, White P, Wilson RK, Mardis ER, Pierson CR, Ostendorf AP. Somatic SLC35A2 mosaicism correlates with clinical findings in epilepsy brain tissue. Neurol Genet. 2020 Aug; 6: e460.
Bedrosian TA, Quayle C, Novaresi N, Gage FH. Early life experience drives structural variation of neural genomes in mice. Science. 2018 Mar 23; 359: 1395-1399.
View More Publications
Research
Our team takes a translational approach to study mechanisms of neurodevelopmental diseases, such as brain malformation, epilepsy, and autism. We combine characterization of patient brain specimens with functional modeling in patient-derived cell lines and transgenic mice, with the goal of generating knowledge that will lead to best outcomes for patients. Publications
Townsend SE, Westfall JJ, Navarro JB, Koboldt DC, Mardis ER, Miller KE, Bedrosian TA. Single-nuclei transcriptomics enable detection of somatic variants in patient brain tissue. Sci Rep. 2023 Jan 11; 13: 527.
Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.
Fair SR, Schwind W, Julian D, Biel A, Guo G, Rutherford R, Ramadesikan S, Westfall J, Miller KE, Kararoudi MN, Hickey SE, Mosher TM, McBride KL, Neinast R, Fitch J, Lee D, White P, Wilson RK, Bedrosian TA, Koboldt DC, Hester ME. Cerebral organoids containing an AUTS2 missense variant model microcephaly. Brain. 2022 Jul 8;
Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;
Tan K, Kim ME, Song HW, Skarbrevik D, Babajanian E, Bedrosian TA, Gage FH, Wilkinson MF. The Rhox gene cluster suppresses germline LINE1 transposition. Proc Natl Acad Sci U S A. 2021 Jun 8; 118:
Koboldt DC, Miller KE, Miller AR, Bush JM, McGrath S, Leraas K, Crist E, Fair S, Schwind W, Wijeratne S, Fitch J, Leonard J, Shaikhouni A, Hester ME, Magrini V, Ho ML, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Bedrosian TA. PTEN somatic mutations contribute to spectrum of cerebral overgrowth. Brain. 2021 May 28;
Bedrosian TA, Houtman J, Eguiguren JS, Ghassemzadeh S, Rund N, Novaresi NM, Hu L, Parylak SL, Denli AM, Randolph-Moore L, Namba T, Gage FH, Toda T. Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. EMBO J. 2021 Feb 1; 40: e105819.
Fair SR, Julian D, Hartlaub AM, Pusuluri ST, Malik G, Summerfied TL, Zhao G, Hester AB, Ackerman WE 4th, Hollingsworth EW, Ali M, McElroy CA, Buhimschi IA, Imitola J, Maitre NL, Bedrosian TA, Hester ME. Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development. Stem Cell Reports. 2020 Oct 13; 15: 855-868.
Miller KE, Koboldt DC, Schieffer KM, Bedrosian TA, Crist E, Sheline A, Leraas K, Magrini V, Zhong H, Brennan P, Bush J, Fitch J, Bir N, Miller AR, Cottrell CE, Leonard J, Pindrik JA, Rusin JA, Shah SH, White P, Wilson RK, Mardis ER, Pierson CR, Ostendorf AP. Somatic SLC35A2 mosaicism correlates with clinical findings in epilepsy brain tissue. Neurol Genet. 2020 Aug; 6: e460.
Bedrosian TA, Quayle C, Novaresi N, Gage FH. Early life experience drives structural variation of neural genomes in mice. Science. 2018 Mar 23; 359: 1395-1399.
View More Publications
Research
Our team takes a translational approach to study mechanisms of neurodevelopmental diseases, such as brain malformation, epilepsy, and autism. We combine characterization of patient brain specimens with functional modeling in patient-derived cell lines and transgenic mice, with the goal of generating knowledge that will lead to best outcomes for patients. Publications
Townsend SE, Westfall JJ, Navarro JB, Koboldt DC, Mardis ER, Miller KE, Bedrosian TA. Single-nuclei transcriptomics enable detection of somatic variants in patient brain tissue. Sci Rep. 2023 Jan 11; 13: 527.
Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.
Fair SR, Schwind W, Julian D, Biel A, Guo G, Rutherford R, Ramadesikan S, Westfall J, Miller KE, Kararoudi MN, Hickey SE, Mosher TM, McBride KL, Neinast R, Fitch J, Lee D, White P, Wilson RK, Bedrosian TA, Koboldt DC, Hester ME. Cerebral organoids containing an AUTS2 missense variant model microcephaly. Brain. 2022 Jul 8;
Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;
Tan K, Kim ME, Song HW, Skarbrevik D, Babajanian E, Bedrosian TA, Gage FH, Wilkinson MF. The Rhox gene cluster suppresses germline LINE1 transposition. Proc Natl Acad Sci U S A. 2021 Jun 8; 118:
Koboldt DC, Miller KE, Miller AR, Bush JM, McGrath S, Leraas K, Crist E, Fair S, Schwind W, Wijeratne S, Fitch J, Leonard J, Shaikhouni A, Hester ME, Magrini V, Ho ML, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Bedrosian TA. PTEN somatic mutations contribute to spectrum of cerebral overgrowth. Brain. 2021 May 28;
Bedrosian TA, Houtman J, Eguiguren JS, Ghassemzadeh S, Rund N, Novaresi NM, Hu L, Parylak SL, Denli AM, Randolph-Moore L, Namba T, Gage FH, Toda T. Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. EMBO J. 2021 Feb 1; 40: e105819.
Fair SR, Julian D, Hartlaub AM, Pusuluri ST, Malik G, Summerfied TL, Zhao G, Hester AB, Ackerman WE 4th, Hollingsworth EW, Ali M, McElroy CA, Buhimschi IA, Imitola J, Maitre NL, Bedrosian TA, Hester ME. Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development. Stem Cell Reports. 2020 Oct 13; 15: 855-868.
Miller KE, Koboldt DC, Schieffer KM, Bedrosian TA, Crist E, Sheline A, Leraas K, Magrini V, Zhong H, Brennan P, Bush J, Fitch J, Bir N, Miller AR, Cottrell CE, Leonard J, Pindrik JA, Rusin JA, Shah SH, White P, Wilson RK, Mardis ER, Pierson CR, Ostendorf AP. Somatic SLC35A2 mosaicism correlates with clinical findings in epilepsy brain tissue. Neurol Genet. 2020 Aug; 6: e460.
Bedrosian TA, Quayle C, Novaresi N, Gage FH. Early life experience drives structural variation of neural genomes in mice. Science. 2018 Mar 23; 359: 1395-1399.
View More Publications
Our team takes a translational approach to study mechanisms of neurodevelopmental diseases, such as brain malformation, epilepsy, and autism. We combine characterization of patient brain specimens with functional modeling in patient-derived cell lines and transgenic mice, with the goal of generating knowledge that will lead to best outcomes for patients. Publications
Townsend SE, Westfall JJ, Navarro JB, Koboldt DC, Mardis ER, Miller KE, Bedrosian TA. Single-nuclei transcriptomics enable detection of somatic variants in patient brain tissue. Sci Rep. 2023 Jan 11; 13: 527.
Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.
Fair SR, Schwind W, Julian D, Biel A, Guo G, Rutherford R, Ramadesikan S, Westfall J, Miller KE, Kararoudi MN, Hickey SE, Mosher TM, McBride KL, Neinast R, Fitch J, Lee D, White P, Wilson RK, Bedrosian TA, Koboldt DC, Hester ME. Cerebral organoids containing an AUTS2 missense variant model microcephaly. Brain. 2022 Jul 8;
Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;
Tan K, Kim ME, Song HW, Skarbrevik D, Babajanian E, Bedrosian TA, Gage FH, Wilkinson MF. The Rhox gene cluster suppresses germline LINE1 transposition. Proc Natl Acad Sci U S A. 2021 Jun 8; 118:
Koboldt DC, Miller KE, Miller AR, Bush JM, McGrath S, Leraas K, Crist E, Fair S, Schwind W, Wijeratne S, Fitch J, Leonard J, Shaikhouni A, Hester ME, Magrini V, Ho ML, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Bedrosian TA. PTEN somatic mutations contribute to spectrum of cerebral overgrowth. Brain. 2021 May 28;
Bedrosian TA, Houtman J, Eguiguren JS, Ghassemzadeh S, Rund N, Novaresi NM, Hu L, Parylak SL, Denli AM, Randolph-Moore L, Namba T, Gage FH, Toda T. Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. EMBO J. 2021 Feb 1; 40: e105819.
Fair SR, Julian D, Hartlaub AM, Pusuluri ST, Malik G, Summerfied TL, Zhao G, Hester AB, Ackerman WE 4th, Hollingsworth EW, Ali M, McElroy CA, Buhimschi IA, Imitola J, Maitre NL, Bedrosian TA, Hester ME. Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development. Stem Cell Reports. 2020 Oct 13; 15: 855-868.
Miller KE, Koboldt DC, Schieffer KM, Bedrosian TA, Crist E, Sheline A, Leraas K, Magrini V, Zhong H, Brennan P, Bush J, Fitch J, Bir N, Miller AR, Cottrell CE, Leonard J, Pindrik JA, Rusin JA, Shah SH, White P, Wilson RK, Mardis ER, Pierson CR, Ostendorf AP. Somatic SLC35A2 mosaicism correlates with clinical findings in epilepsy brain tissue. Neurol Genet. 2020 Aug; 6: e460.
Bedrosian TA, Quayle C, Novaresi N, Gage FH. Early life experience drives structural variation of neural genomes in mice. Science. 2018 Mar 23; 359: 1395-1399.
View More Publications
Our team takes a translational approach to study mechanisms of neurodevelopmental diseases, such as brain malformation, epilepsy, and autism. We combine characterization of patient brain specimens with functional modeling in patient-derived cell lines and transgenic mice, with the goal of generating knowledge that will lead to best outcomes for patients.
Townsend SE, Westfall JJ, Navarro JB, Koboldt DC, Mardis ER, Miller KE, Bedrosian TA. Single-nuclei transcriptomics enable detection of somatic variants in patient brain tissue. Sci Rep. 2023 Jan 11; 13: 527.
Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.
Fair SR, Schwind W, Julian D, Biel A, Guo G, Rutherford R, Ramadesikan S, Westfall J, Miller KE, Kararoudi MN, Hickey SE, Mosher TM, McBride KL, Neinast R, Fitch J, Lee D, White P, Wilson RK, Bedrosian TA, Koboldt DC, Hester ME. Cerebral organoids containing an AUTS2 missense variant model microcephaly. Brain. 2022 Jul 8;
Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;
Tan K, Kim ME, Song HW, Skarbrevik D, Babajanian E, Bedrosian TA, Gage FH, Wilkinson MF. The Rhox gene cluster suppresses germline LINE1 transposition. Proc Natl Acad Sci U S A. 2021 Jun 8; 118:
Koboldt DC, Miller KE, Miller AR, Bush JM, McGrath S, Leraas K, Crist E, Fair S, Schwind W, Wijeratne S, Fitch J, Leonard J, Shaikhouni A, Hester ME, Magrini V, Ho ML, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Bedrosian TA. PTEN somatic mutations contribute to spectrum of cerebral overgrowth. Brain. 2021 May 28;
Bedrosian TA, Houtman J, Eguiguren JS, Ghassemzadeh S, Rund N, Novaresi NM, Hu L, Parylak SL, Denli AM, Randolph-Moore L, Namba T, Gage FH, Toda T. Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. EMBO J. 2021 Feb 1; 40: e105819.
Fair SR, Julian D, Hartlaub AM, Pusuluri ST, Malik G, Summerfied TL, Zhao G, Hester AB, Ackerman WE 4th, Hollingsworth EW, Ali M, McElroy CA, Buhimschi IA, Imitola J, Maitre NL, Bedrosian TA, Hester ME. Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development. Stem Cell Reports. 2020 Oct 13; 15: 855-868.
Miller KE, Koboldt DC, Schieffer KM, Bedrosian TA, Crist E, Sheline A, Leraas K, Magrini V, Zhong H, Brennan P, Bush J, Fitch J, Bir N, Miller AR, Cottrell CE, Leonard J, Pindrik JA, Rusin JA, Shah SH, White P, Wilson RK, Mardis ER, Pierson CR, Ostendorf AP. Somatic SLC35A2 mosaicism correlates with clinical findings in epilepsy brain tissue. Neurol Genet. 2020 Aug; 6: e460.
Bedrosian TA, Quayle C, Novaresi N, Gage FH. Early life experience drives structural variation of neural genomes in mice. Science. 2018 Mar 23; 359: 1395-1399.
View More Publications
- Townsend SE, Westfall JJ, Navarro JB, Koboldt DC, Mardis ER, Miller KE, Bedrosian TA. Single-nuclei transcriptomics enable detection of somatic variants in patient brain tissue. Sci Rep. 2023 Jan 11; 13: 527.
- Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.
- Fair SR, Schwind W, Julian D, Biel A, Guo G, Rutherford R, Ramadesikan S, Westfall J, Miller KE, Kararoudi MN, Hickey SE, Mosher TM, McBride KL, Neinast R, Fitch J, Lee D, White P, Wilson RK, Bedrosian TA, Koboldt DC, Hester ME. Cerebral organoids containing an AUTS2 missense variant model microcephaly. Brain. 2022 Jul 8;
- Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;
- Tan K, Kim ME, Song HW, Skarbrevik D, Babajanian E, Bedrosian TA, Gage FH, Wilkinson MF. The Rhox gene cluster suppresses germline LINE1 transposition. Proc Natl Acad Sci U S A. 2021 Jun 8; 118:
- Koboldt DC, Miller KE, Miller AR, Bush JM, McGrath S, Leraas K, Crist E, Fair S, Schwind W, Wijeratne S, Fitch J, Leonard J, Shaikhouni A, Hester ME, Magrini V, Ho ML, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Bedrosian TA. PTEN somatic mutations contribute to spectrum of cerebral overgrowth. Brain. 2021 May 28;
- Bedrosian TA, Houtman J, Eguiguren JS, Ghassemzadeh S, Rund N, Novaresi NM, Hu L, Parylak SL, Denli AM, Randolph-Moore L, Namba T, Gage FH, Toda T. Lamin B1 decline underlies age-related loss of adult hippocampal neurogenesis. EMBO J. 2021 Feb 1; 40: e105819.
- Fair SR, Julian D, Hartlaub AM, Pusuluri ST, Malik G, Summerfied TL, Zhao G, Hester AB, Ackerman WE 4th, Hollingsworth EW, Ali M, McElroy CA, Buhimschi IA, Imitola J, Maitre NL, Bedrosian TA, Hester ME. Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development. Stem Cell Reports. 2020 Oct 13; 15: 855-868.
- Miller KE, Koboldt DC, Schieffer KM, Bedrosian TA, Crist E, Sheline A, Leraas K, Magrini V, Zhong H, Brennan P, Bush J, Fitch J, Bir N, Miller AR, Cottrell CE, Leonard J, Pindrik JA, Rusin JA, Shah SH, White P, Wilson RK, Mardis ER, Pierson CR, Ostendorf AP. Somatic SLC35A2 mosaicism correlates with clinical findings in epilepsy brain tissue. Neurol Genet. 2020 Aug; 6: e460.
- Bedrosian TA, Quayle C, Novaresi N, Gage FH. Early life experience drives structural variation of neural genomes in mice. Science. 2018 Mar 23; 359: 1395-1399.
Education
Date of Appointment at Nationwide Children’s Hospital: 08/03/2020
Graduate School
The Ohio State University
Date Completed: 05/01/2013
Undergraduate School
University of Michigan
Date Completed: 05/01/2008
Education
Date of Appointment at Nationwide Children’s Hospital: 08/03/2020
Graduate School
The Ohio State University
Date Completed: 05/01/2013
Undergraduate School
University of Michigan
Date Completed: 05/01/2008
Education
Date of Appointment at Nationwide Children’s Hospital: 08/03/2020
Graduate School
The Ohio State University
Date Completed: 05/01/2013
Undergraduate School
University of Michigan
Date Completed: 05/01/2008
Date of Appointment at Nationwide Children’s Hospital: 08/03/2020
Graduate School
The Ohio State University
Date Completed: 05/01/2013
Undergraduate School
University of Michigan
Date Completed: 05/01/2008
Date of Appointment at Nationwide Children’s Hospital: 08/03/2020
Graduate School
The Ohio State University
Date Completed: 05/01/2013
Undergraduate School
University of Michigan
Date Completed: 05/01/2008
Contact Information
Institute for Genomic Medicine
Call us at: (614) 355-3147
Email Tracy A Bedrosian
575 Children's CrossroadColumbus, OH 43215 (map)
Contact Information
Institute for Genomic Medicine
Call us at: (614) 355-3147
Email Tracy A Bedrosian
575 Children's CrossroadColumbus, OH 43215 (map)
Contact Information
Institute for Genomic Medicine
Call us at: (614) 355-3147
Email Tracy A Bedrosian
575 Children's CrossroadColumbus, OH 43215 (map)
Institute for Genomic Medicine
Call us at: (614) 355-3147
Email Tracy A Bedrosian
575 Children's CrossroadColumbus, OH 43215 (map)
Call us at: (614) 355-3147
Email Tracy A Bedrosian
575 Children's CrossroadColumbus, OH 43215 (map)
Call us at: (614) 355-3147
Email Tracy A Bedrosian
575 Children's CrossroadColumbus, OH 43215 (map)
- Call us at:
- (614) 355-3147
- Email Tracy A Bedrosian
- 575 Children’s CrossroadColumbus, OH 43215 (map)
