We’re a highly collaborative group, focusing on epigenetics and genomics. We investigate fundamental modes of gene regulation and how they can be disrupted in human disease. We are motivated to understand chromatin structure in the context of epigenetic activation and repression, as we define projects at the interface of epigenomics and pediatric cancer biology. Our view is that understanding basic epigenetic mechanisms and vulnerabilities will provide the groundwork for precision therapies.
Understanding Epigenetic Regulation in Childhood Cancer
Nucleosomes are the most fundamental unit of DNA packaging in eukaryotes and, therefore, the most fundamental subunit of epigenetics studies. Since nucleosomes are segments of wrapped DNA that resemble yarn wrapped around a spool, these hand-crocheted models made of yarn by Dr. Emma Chory, a post-doctoral fellow at Massachusetts Institute of Technology, are an extremely fitting way to showcase what our researchers examine in their work!
While pediatric cancers often have low mutational burden, alterations can drive changes in the epigenetic landscape. Our group seeks to understand chromatin deregulation in cancers with low mutational frequencies. We have a special interest in understanding the central determinants for 3D genome organization in cancer, defining how chromatin interactions change in human disease, and for investigating how the epigenome interacts with chemotherapeutics. Epigenomics for Chromatin Architecture In order to define altered epigenetic states, our group develops new methods for understanding chromatin structure, and how proteins bind to the genome. Our methods are driven by questions connecting chromatin remodeling and genome architecture.
Lab Staff
Benjamin Stanton, PhD Principal Investigator Benjamin Stanton leads the Systems Epigenetics Group at Nationwide Children’s and The Ohio State University College of Medicine. His main research interests relate to understanding chromatin activation in childhood cancer, understanding how epigenetic repression influences genome organization in human disease and developing interdisciplinary approaches for new methods in systems epigenetics. Dr. Stanton cares deeply about mentoring the next generation of scientists. He also enjoys spending time with his wife, Abby, and his son, Zev.
Meng Wang, PhD Senior Bioinformatics Scientist In the Stanton Lab, Meng Wang, PhD, analyzes next generation sequencing data. Dr. Wang has a doctorate from The Ohio State University with a focus in statistical genetics. She completed her postdoctoral research studying the genetic association between rare variants and epilepsy.
Alexi Tallan Doctoral Researcher, The Ohio State University Molecular, Cellular and Developmental Biology Program Lex Tallan, PhD, works at the interface of epigenomics, biochemistry and data analysis to understand how rare transcription factors function in childhood tumors.
Rachel Hoffman, PhD Postdoctoral Fellow Rachel Hoffman, PhD, investigates chromatin replication and is studying how the epigenome is inherited in pediatric cancer.
Corinne Haines, PhD Bioinformatics Analyst Corinne Haines, PhD, investigates genome structure-function relationships and epigenetic mechanisms through hypothesis driven informatics.
Join Our Systems Epigenetics GroupWe’re recruiting! My lab is looking for motivated, curious and dedicated postdocs and graduate students. Feel free to reach out to us!First Name
Last Name
Subject
Message
We’re a highly collaborative group, focusing on epigenetics and genomics. We investigate fundamental modes of gene regulation and how they can be disrupted in human disease.
We are motivated to understand chromatin structure in the context of epigenetic activation and repression, as we define projects at the interface of epigenomics and pediatric cancer biology. Our view is that understanding basic epigenetic mechanisms and vulnerabilities will provide the groundwork for precision therapies.
Understanding Epigenetic Regulation in Childhood Cancer
Nucleosomes are the most fundamental unit of DNA packaging in eukaryotes and, therefore, the most fundamental subunit of epigenetics studies. Since nucleosomes are segments of wrapped DNA that resemble yarn wrapped around a spool, these hand-crocheted models made of yarn by Dr. Emma Chory, a post-doctoral fellow at Massachusetts Institute of Technology, are an extremely fitting way to showcase what our researchers examine in their work!
While pediatric cancers often have low mutational burden, alterations can drive changes in the epigenetic landscape. Our group seeks to understand chromatin deregulation in cancers with low mutational frequencies. We have a special interest in understanding the central determinants for 3D genome organization in cancer, defining how chromatin interactions change in human disease, and for investigating how the epigenome interacts with chemotherapeutics. Epigenomics for Chromatin Architecture In order to define altered epigenetic states, our group develops new methods for understanding chromatin structure, and how proteins bind to the genome. Our methods are driven by questions connecting chromatin remodeling and genome architecture.
Lab Staff
Benjamin Stanton, PhD Principal Investigator Benjamin Stanton leads the Systems Epigenetics Group at Nationwide Children’s and The Ohio State University College of Medicine. His main research interests relate to understanding chromatin activation in childhood cancer, understanding how epigenetic repression influences genome organization in human disease and developing interdisciplinary approaches for new methods in systems epigenetics. Dr. Stanton cares deeply about mentoring the next generation of scientists. He also enjoys spending time with his wife, Abby, and his son, Zev.
Meng Wang, PhD Senior Bioinformatics Scientist In the Stanton Lab, Meng Wang, PhD, analyzes next generation sequencing data. Dr. Wang has a doctorate from The Ohio State University with a focus in statistical genetics. She completed her postdoctoral research studying the genetic association between rare variants and epilepsy.
Alexi Tallan Doctoral Researcher, The Ohio State University Molecular, Cellular and Developmental Biology Program Lex Tallan, PhD, works at the interface of epigenomics, biochemistry and data analysis to understand how rare transcription factors function in childhood tumors.
Rachel Hoffman, PhD Postdoctoral Fellow Rachel Hoffman, PhD, investigates chromatin replication and is studying how the epigenome is inherited in pediatric cancer.
Corinne Haines, PhD Bioinformatics Analyst Corinne Haines, PhD, investigates genome structure-function relationships and epigenetic mechanisms through hypothesis driven informatics.
Join Our Systems Epigenetics GroupWe’re recruiting! My lab is looking for motivated, curious and dedicated postdocs and graduate students. Feel free to reach out to us!First Name
Last Name
Subject
Message
Understanding Epigenetic Regulation in Childhood Cancer
While pediatric cancers often have low mutational burden, alterations can drive changes in the epigenetic landscape. Our group seeks to understand chromatin deregulation in cancers with low mutational frequencies. We have a special interest in understanding the central determinants for 3D genome organization in cancer, defining how chromatin interactions change in human disease, and for investigating how the epigenome interacts with chemotherapeutics.
Epigenomics for Chromatin Architecture
In order to define altered epigenetic states, our group develops new methods for understanding chromatin structure, and how proteins bind to the genome. Our methods are driven by questions connecting chromatin remodeling and genome architecture.
Lab Staff
Benjamin Stanton, PhD Principal Investigator Benjamin Stanton leads the Systems Epigenetics Group at Nationwide Children’s and The Ohio State University College of Medicine. His main research interests relate to understanding chromatin activation in childhood cancer, understanding how epigenetic repression influences genome organization in human disease and developing interdisciplinary approaches for new methods in systems epigenetics. Dr. Stanton cares deeply about mentoring the next generation of scientists. He also enjoys spending time with his wife, Abby, and his son, Zev.
Benjamin Stanton, PhD Principal Investigator
Benjamin Stanton leads the Systems Epigenetics Group at Nationwide Children’s and The Ohio State University College of Medicine. His main research interests relate to understanding chromatin activation in childhood cancer, understanding how epigenetic repression influences genome organization in human disease and developing interdisciplinary approaches for new methods in systems epigenetics. Dr. Stanton cares deeply about mentoring the next generation of scientists. He also enjoys spending time with his wife, Abby, and his son, Zev.
Meng Wang, PhD Senior Bioinformatics Scientist In the Stanton Lab, Meng Wang, PhD, analyzes next generation sequencing data. Dr. Wang has a doctorate from The Ohio State University with a focus in statistical genetics. She completed her postdoctoral research studying the genetic association between rare variants and epilepsy.
Alexi Tallan Doctoral Researcher, The Ohio State University Molecular, Cellular and Developmental Biology Program Lex Tallan, PhD, works at the interface of epigenomics, biochemistry and data analysis to understand how rare transcription factors function in childhood tumors.
Rachel Hoffman, PhD Postdoctoral Fellow Rachel Hoffman, PhD, investigates chromatin replication and is studying how the epigenome is inherited in pediatric cancer.
Corinne Haines, PhD Bioinformatics Analyst Corinne Haines, PhD, investigates genome structure-function relationships and epigenetic mechanisms through hypothesis driven informatics.
Meng Wang, PhD Senior Bioinformatics Scientist In the Stanton Lab, Meng Wang, PhD, analyzes next generation sequencing data. Dr. Wang has a doctorate from The Ohio State University with a focus in statistical genetics. She completed her postdoctoral research studying the genetic association between rare variants and epilepsy.
Meng Wang, PhD Senior Bioinformatics Scientist
In the Stanton Lab, Meng Wang, PhD, analyzes next generation sequencing data. Dr. Wang has a doctorate from The Ohio State University with a focus in statistical genetics. She completed her postdoctoral research studying the genetic association between rare variants and epilepsy.
Alexi Tallan Doctoral Researcher, The Ohio State University Molecular, Cellular and Developmental Biology Program Lex Tallan, PhD, works at the interface of epigenomics, biochemistry and data analysis to understand how rare transcription factors function in childhood tumors.
Alexi Tallan Doctoral Researcher, The Ohio State University Molecular, Cellular and Developmental Biology Program
Lex Tallan, PhD, works at the interface of epigenomics, biochemistry and data analysis to understand how rare transcription factors function in childhood tumors.
Rachel Hoffman, PhD Postdoctoral Fellow Rachel Hoffman, PhD, investigates chromatin replication and is studying how the epigenome is inherited in pediatric cancer.
Rachel Hoffman, PhD Postdoctoral Fellow
Rachel Hoffman, PhD, investigates chromatin replication and is studying how the epigenome is inherited in pediatric cancer.
Corinne Haines, PhD Bioinformatics Analyst Corinne Haines, PhD, investigates genome structure-function relationships and epigenetic mechanisms through hypothesis driven informatics.
Corinne Haines, PhD Bioinformatics Analyst
Corinne Haines, PhD, investigates genome structure-function relationships and epigenetic mechanisms through hypothesis driven informatics.
Join Our Systems Epigenetics GroupWe’re recruiting! My lab is looking for motivated, curious and dedicated postdocs and graduate students. Feel free to reach out to us!First Name
Last Name
Subject
Message
Join Our Systems Epigenetics Group
We’re recruiting! My lab is looking for motivated, curious and dedicated postdocs and graduate students. Feel free to reach out to us!
