Shalini C Reshmi

Contact Information

Call us at: (614) 722-5321

Fax us at: (614) 355-6833

Institute for Genomic MedicineLaboratory Medicine/ Anatomic Pathology575 Childrens CrossroadColumbus, OH 43215 (map)

Learn more about Shalini C. Reshmi

Biography

Shalini Reshmi, PhD, received her doctoral degree from the University of Pittsburgh, Graduate School of Public Health. She completed Clinical Genetics fellowships at the University of Chicago Pritzker School of Medicine and is board certified in both Clinical Cytogenetics and Clinical Molecular Genetics by the American Board of Medical Genetics and Genomics (ABMGG). Her areas of responsibility include: clinical case sign out, CAP compliance and proficiency testing, and implementation of clinical laboratory screening/diagnostic assays. Dr. Reshmi is an Associate Professor (Clinical) in the departments of Pathology and Pediatrics at the Ohio State University College of Medicine and Co-Investigator of the Children’s Oncology Group (COG) Reference laboratory within the Biopathology Center, overseeing laboratory diagnostics for several COG disease disciplines.

See Shalini C. Reshmi’s Curriculum Vitae (CV)

Academic and Clinical Areas

Pathology Fellowship

Faculty

Pathology and Laboratory Medicine

Clinical Pathology Team

Clinical Pathology

Director, Institute for Genomic Medicine Clinical Laboratory

Primary Department

Institute for Genomic Medicine

Primary Section

Clinical Pathology

Awards, Honors & Organizations

Best Doctoral Dissertation, Human Genetics, Delta Omega National Honor Society, Omicron Chapter Pittsburgh, PA, 2005 Public Health Dean’s Scholarship Recipient, Outstanding Doctoral Student, University of Pittsburgh, 2004 Invited Participant, 3rd Annual St. Jude National Graduate Student Symposium, St. Jude Children’s Research Hospital, Memphis, TN, 2004 Member, ClinGen Somatic Cancer Variant Curation Expert Panel, 2022 - Present Member, Cancer Genome Consortium, 2018 - Present Member, American Society of Hematology, 2016 - Present Discipline Committee Chair, Laboratory Science,, Children’s Oncology Group, 2014 - Present CAP Inspector, Certified Molecular Pathology and Cytogenetics, 2011 - Present Fellow, American College of Medical Genetics and Genomics, 2009 - Present Member, Children’s Oncology Group, 2008 - Present Member, Association for Molecular Pathology, 2008 - Present Co-Investigator, Children’s Oncology Group, 2008 - Present Member, American College of Medical Genetics, 2007 - Present Member, American Society of Human Genetics, 2001 - Present Member, American Society of Human Genetics, 1994 - Present

Research

Interests

Translational Studies in Cancer Diagnostics

View My Publications Publications

                  Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, Parker M, Chen X, Elsayed AH, Pathak O, Li Y, Fan Y, Michael JR, Rusch M, Wilkinson MR, Foy S, Hedges DJ, Newman S, Zhou X, Wang J, Reilly C, Sioson E, Rice SV, Pastor Loyola V, Wu G, Rampersaud E, Reshmi SC, Gastier-Foster J, Guidry Auvil JM, Gesuwan P, Smith MA, Winick N, Carroll AJ, Heerema NA, Harvey RC, Willman CL, Larsen E, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Winter SS, Burke MJ, Salzer W, Dunsmore KP, Angiolillo AL, Crews KR, Downing JR, Jeha S, Pui CH, Evans WE, Yang JJ, Relling MV, Gerhard DS, Loh ML, Hunger SP, Zhang J, Mullighan CG. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet. 2022 Sep; 54: 1376-1389.

                


                  Mathew MT, Antoniou A, Ramesh N, Hu M, Gaither J, Mouhlas D, Hashimoto S, Humphrey M, Matthews T, Hunter JM, Reshmi S, Schultz M, Lee K, Pfau R, Cottrell C, McBride KL, Navin NE, Chaudhari BP, Leung ML. A Decade's Experience in Pediatric Chromosomal Microarray Reveals Distinct Characteristics Across Ordering Specialties. J Mol Diagn. 2022 Jun 16;  

                


                  Yang H, Zhang H, Luan Y, Liu T, Yang W, Roberts KG, Qian MX, Zhang B, Yang W, Perez-Andreu V, Xu J, Iyyanki S, Kuang D, Stasiak LA, Reshmi SC, Gastier-Foster J, Smith C, Pui CH, Evans WE, Hunger SP, Platanias LC, Relling MV, Mullighan CG, Loh ML, Yue F, Yang JJ. Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation. Nat Genet. 2022 Feb; 54: 170-179.

                


                  Hunter JM, Massingham LJ, Manickam K, Bartholomew D, Williamson RK, Schwab JL, Marhabaie M, Siemon A, de Los Reyes E, Reshmi SC, Cottrell CE, Wilson RK, Koboldt DC. Inherited and de novo variants extend the etiology of TAOK1-associated neurodevelopmental disorder. Cold Spring Harb Mol Case Stud. 2022 Feb; 8: 

                


                  Irwin MS, Naranjo A, Zhang FF, Cohn SL, London WB, Gastier-Foster JM, Ramirez NC, Pfau R, Reshmi S, Wagner E, Nuchtern J, Asgharzadeh S, Shimada H, Maris JM, Bagatell R, Park JR, Hogarty MD. Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group. J Clin Oncol. 2021 Oct 10; 39: 3229-3241.

                


                  Kraft MT, Mehyar LS, Prince BT, Reshmi SC, Abraham RS, Abu-Arja R. Immune Reconstitution after Hematopoietic Stem Cell Transplantation in Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome Type 1. J Clin Immunol. 2021 Jul; 41: 1089-1094.

                


                  Akhavanfard S, Nohr E, AlNajjar M, Haughn M, Hashimoto S, Deeg C, Pfau R, Brundler MA, Reshmi SC. 5' ALK Amplification in Neuroblastoma: A Case Report. Case Rep Oncol. 2021 Jan-Apr; 14: 585-591.

                


                  Pfeifer H, Cazzaniga G, van der Velden VHJ, Cayuela JM, Schäfer B, Spinelli O, Akiki S, Avigad S, Bendit I, Borg K, Cavé H, Elia L, Reshmi SC, Gerrard G, Hayette S, Hermanson M, Juh A, Jurcek T, Chillón MC, Homburg C, Martinelli G, Kairisto V, Lange T, Lion T, Mueller MC, Pane F, Rai L, Damm-Welk C, Sacha T, Schnittger S, Touloumenidou T, Valerhaugen H, Vandenberghe P, Zuna J, Serve H, Herrmann E, Markovic S, Dongen JJMV, Ottmann OG. Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph?+?ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1. Leukemia. 2019 Aug; 33: 1910-1922.

                


                  Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, Devidas M, Dai Y, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mrózek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans WE, Jeha S, Pui CH, Yang J, Paietta E, Downing JR, Relling MV, Zhang J, Loh ML, Hunger SP, Mullighan CG. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019 Feb; 51: 296-307.

                


                  Roberts KG, Reshmi SC, Harvey RC, Chen IM, Patel K, Stonerock E, Jenkins H, Dai Y, Valentine M, Gu Z, Zhao Y, Zhang J, Payne-Turner D, Devidas M, Heerema NA, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Mattano LA Jr, Maloney KW, Carroll WL, Loh ML, Willman CL, Gastier-Foster JM, Mullighan CG, Hunger SP. Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group. Blood. 2018 Aug 23; 132: 815-824.

                


                  Barrie ES, Li Y, Lamb-Thrush D, Hashimoto S, Matthews T, Mouhlas D, Pyatt R, Reshmi SC, Gastier-Foster JM, Pfau R, Astbury C. Pericentromeric regions of homozygosity on the X chromosome: Another likely benign population variant. Eur J Med Genet. 2018 Jul; 61: 416-420.

                


                  Tran TH, Harris MH, Nguyen JV, Blonquist TM, Stevenson KE, Stonerock E, Asselin BL, Athale UH, Clavell LA, Cole PD, Kelly KM, Laverdiere C, Leclerc JM, Michon B, Schorin MA, Welch JJG, Reshmi SC, Neuberg DS, Sallan SE, Loh ML, Silverman LB. Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia. Blood Adv. 2018 Mar 13; 2: 529-533.

                


                  Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group. Blood. 2017 Jun 22; 129: 3352-3361.

View More Publications

Clinical Interests

Neuroblastoma Ph-like Acute Lymphoblastic Leukemia Wilms Tumor

Professional Experience

2008 - Present (Clinical)Pathology, The Ohio State University, Assistant Professor2008 - Present Nationwide Children’s Hospital, Department of Laboratory Medicine, Assistant Director of the Cytogenetics and Molecular Genetics Laboratories2008 - Present The Research Institute at Nationwide Children’s Hospital, Assistant Director of the Children’s Oncology Group Reference Laboratory2005 - 2008 Clinical Cytogenetics and Molecular Genetics, Fellow2001 - 2005 Cancer Cytogenetics; The University of Pittsburgh, Graduate Student Researcher2001 - 2001 Cytogenetics Facility; University of Pittsburgh Cancer Institute and Center for Human Genetics and Integrative Biology, Supervisor1999 - 2001 Allegheny General Hospital, Cytogenetic Technologist

Contact Information

Institute for Genomic Medicine

Call us at: (614) 722-5321

Fax us at: (614) 355-6833

                    Laboratory Medicine/ Anatomic Pathology575 Childrens CrossroadColumbus, OH 43215 (map)

Connect with Shalini C. Reshmi

Connect on LinkedIn

Connect on ResearchGate

Contact Information

Call us at: (614) 722-5321

Fax us at: (614) 355-6833

Institute for Genomic MedicineLaboratory Medicine/ Anatomic Pathology575 Childrens CrossroadColumbus, OH 43215 (map)

Learn more about Shalini C. Reshmi

Biography

Shalini Reshmi, PhD, received her doctoral degree from the University of Pittsburgh, Graduate School of Public Health. She completed Clinical Genetics fellowships at the University of Chicago Pritzker School of Medicine and is board certified in both Clinical Cytogenetics and Clinical Molecular Genetics by the American Board of Medical Genetics and Genomics (ABMGG). Her areas of responsibility include: clinical case sign out, CAP compliance and proficiency testing, and implementation of clinical laboratory screening/diagnostic assays. Dr. Reshmi is an Associate Professor (Clinical) in the departments of Pathology and Pediatrics at the Ohio State University College of Medicine and Co-Investigator of the Children’s Oncology Group (COG) Reference laboratory within the Biopathology Center, overseeing laboratory diagnostics for several COG disease disciplines.

See Shalini C. Reshmi’s Curriculum Vitae (CV)

Academic and Clinical Areas

Pathology Fellowship

Faculty

Pathology and Laboratory Medicine

Clinical Pathology Team

Clinical Pathology

Director, Institute for Genomic Medicine Clinical Laboratory

Primary Department

Institute for Genomic Medicine

Primary Section

Clinical Pathology

Awards, Honors & Organizations

Best Doctoral Dissertation, Human Genetics, Delta Omega National Honor Society, Omicron Chapter Pittsburgh, PA, 2005 Public Health Dean’s Scholarship Recipient, Outstanding Doctoral Student, University of Pittsburgh, 2004 Invited Participant, 3rd Annual St. Jude National Graduate Student Symposium, St. Jude Children’s Research Hospital, Memphis, TN, 2004 Member, ClinGen Somatic Cancer Variant Curation Expert Panel, 2022 - Present Member, Cancer Genome Consortium, 2018 - Present Member, American Society of Hematology, 2016 - Present Discipline Committee Chair, Laboratory Science,, Children’s Oncology Group, 2014 - Present CAP Inspector, Certified Molecular Pathology and Cytogenetics, 2011 - Present Fellow, American College of Medical Genetics and Genomics, 2009 - Present Member, Children’s Oncology Group, 2008 - Present Member, Association for Molecular Pathology, 2008 - Present Co-Investigator, Children’s Oncology Group, 2008 - Present Member, American College of Medical Genetics, 2007 - Present Member, American Society of Human Genetics, 2001 - Present Member, American Society of Human Genetics, 1994 - Present

Research

Interests

Translational Studies in Cancer Diagnostics

View My Publications Publications

                  Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, Parker M, Chen X, Elsayed AH, Pathak O, Li Y, Fan Y, Michael JR, Rusch M, Wilkinson MR, Foy S, Hedges DJ, Newman S, Zhou X, Wang J, Reilly C, Sioson E, Rice SV, Pastor Loyola V, Wu G, Rampersaud E, Reshmi SC, Gastier-Foster J, Guidry Auvil JM, Gesuwan P, Smith MA, Winick N, Carroll AJ, Heerema NA, Harvey RC, Willman CL, Larsen E, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Winter SS, Burke MJ, Salzer W, Dunsmore KP, Angiolillo AL, Crews KR, Downing JR, Jeha S, Pui CH, Evans WE, Yang JJ, Relling MV, Gerhard DS, Loh ML, Hunger SP, Zhang J, Mullighan CG. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet. 2022 Sep; 54: 1376-1389.

                


                  Mathew MT, Antoniou A, Ramesh N, Hu M, Gaither J, Mouhlas D, Hashimoto S, Humphrey M, Matthews T, Hunter JM, Reshmi S, Schultz M, Lee K, Pfau R, Cottrell C, McBride KL, Navin NE, Chaudhari BP, Leung ML. A Decade's Experience in Pediatric Chromosomal Microarray Reveals Distinct Characteristics Across Ordering Specialties. J Mol Diagn. 2022 Jun 16;  

                


                  Yang H, Zhang H, Luan Y, Liu T, Yang W, Roberts KG, Qian MX, Zhang B, Yang W, Perez-Andreu V, Xu J, Iyyanki S, Kuang D, Stasiak LA, Reshmi SC, Gastier-Foster J, Smith C, Pui CH, Evans WE, Hunger SP, Platanias LC, Relling MV, Mullighan CG, Loh ML, Yue F, Yang JJ. Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation. Nat Genet. 2022 Feb; 54: 170-179.

                


                  Hunter JM, Massingham LJ, Manickam K, Bartholomew D, Williamson RK, Schwab JL, Marhabaie M, Siemon A, de Los Reyes E, Reshmi SC, Cottrell CE, Wilson RK, Koboldt DC. Inherited and de novo variants extend the etiology of TAOK1-associated neurodevelopmental disorder. Cold Spring Harb Mol Case Stud. 2022 Feb; 8: 

                


                  Irwin MS, Naranjo A, Zhang FF, Cohn SL, London WB, Gastier-Foster JM, Ramirez NC, Pfau R, Reshmi S, Wagner E, Nuchtern J, Asgharzadeh S, Shimada H, Maris JM, Bagatell R, Park JR, Hogarty MD. Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group. J Clin Oncol. 2021 Oct 10; 39: 3229-3241.

                


                  Kraft MT, Mehyar LS, Prince BT, Reshmi SC, Abraham RS, Abu-Arja R. Immune Reconstitution after Hematopoietic Stem Cell Transplantation in Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome Type 1. J Clin Immunol. 2021 Jul; 41: 1089-1094.

                


                  Akhavanfard S, Nohr E, AlNajjar M, Haughn M, Hashimoto S, Deeg C, Pfau R, Brundler MA, Reshmi SC. 5' ALK Amplification in Neuroblastoma: A Case Report. Case Rep Oncol. 2021 Jan-Apr; 14: 585-591.

                


                  Pfeifer H, Cazzaniga G, van der Velden VHJ, Cayuela JM, Schäfer B, Spinelli O, Akiki S, Avigad S, Bendit I, Borg K, Cavé H, Elia L, Reshmi SC, Gerrard G, Hayette S, Hermanson M, Juh A, Jurcek T, Chillón MC, Homburg C, Martinelli G, Kairisto V, Lange T, Lion T, Mueller MC, Pane F, Rai L, Damm-Welk C, Sacha T, Schnittger S, Touloumenidou T, Valerhaugen H, Vandenberghe P, Zuna J, Serve H, Herrmann E, Markovic S, Dongen JJMV, Ottmann OG. Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph?+?ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1. Leukemia. 2019 Aug; 33: 1910-1922.

                


                  Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, Devidas M, Dai Y, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mrózek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans WE, Jeha S, Pui CH, Yang J, Paietta E, Downing JR, Relling MV, Zhang J, Loh ML, Hunger SP, Mullighan CG. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019 Feb; 51: 296-307.

                


                  Roberts KG, Reshmi SC, Harvey RC, Chen IM, Patel K, Stonerock E, Jenkins H, Dai Y, Valentine M, Gu Z, Zhao Y, Zhang J, Payne-Turner D, Devidas M, Heerema NA, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Mattano LA Jr, Maloney KW, Carroll WL, Loh ML, Willman CL, Gastier-Foster JM, Mullighan CG, Hunger SP. Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group. Blood. 2018 Aug 23; 132: 815-824.

                


                  Barrie ES, Li Y, Lamb-Thrush D, Hashimoto S, Matthews T, Mouhlas D, Pyatt R, Reshmi SC, Gastier-Foster JM, Pfau R, Astbury C. Pericentromeric regions of homozygosity on the X chromosome: Another likely benign population variant. Eur J Med Genet. 2018 Jul; 61: 416-420.

                


                  Tran TH, Harris MH, Nguyen JV, Blonquist TM, Stevenson KE, Stonerock E, Asselin BL, Athale UH, Clavell LA, Cole PD, Kelly KM, Laverdiere C, Leclerc JM, Michon B, Schorin MA, Welch JJG, Reshmi SC, Neuberg DS, Sallan SE, Loh ML, Silverman LB. Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia. Blood Adv. 2018 Mar 13; 2: 529-533.

                


                  Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group. Blood. 2017 Jun 22; 129: 3352-3361.

View More Publications

Clinical Interests

Neuroblastoma Ph-like Acute Lymphoblastic Leukemia Wilms Tumor

Professional Experience

2008 - Present (Clinical)Pathology, The Ohio State University, Assistant Professor2008 - Present Nationwide Children’s Hospital, Department of Laboratory Medicine, Assistant Director of the Cytogenetics and Molecular Genetics Laboratories2008 - Present The Research Institute at Nationwide Children’s Hospital, Assistant Director of the Children’s Oncology Group Reference Laboratory2005 - 2008 Clinical Cytogenetics and Molecular Genetics, Fellow2001 - 2005 Cancer Cytogenetics; The University of Pittsburgh, Graduate Student Researcher2001 - 2001 Cytogenetics Facility; University of Pittsburgh Cancer Institute and Center for Human Genetics and Integrative Biology, Supervisor1999 - 2001 Allegheny General Hospital, Cytogenetic Technologist

Contact Information

Institute for Genomic Medicine

Call us at: (614) 722-5321

Fax us at: (614) 355-6833

                    Laboratory Medicine/ Anatomic Pathology575 Childrens CrossroadColumbus, OH 43215 (map)

Connect with Shalini C. Reshmi

Connect on LinkedIn

Connect on ResearchGate

Contact Information

Call us at: (614) 722-5321

Fax us at: (614) 355-6833

Institute for Genomic MedicineLaboratory Medicine/ Anatomic Pathology575 Childrens CrossroadColumbus, OH 43215 (map)

Learn more about Shalini C. Reshmi

Contact Information

• Call us at:
• (614) 722-5321
• Fax us at:
• (614) 355-6833
• Institute for Genomic MedicineLaboratory Medicine/ Anatomic Pathology575 Childrens CrossroadColumbus, OH 43215 (map)

Learn more about Shalini C. Reshmi

Biography

Shalini Reshmi, PhD, received her doctoral degree from the University of Pittsburgh, Graduate School of Public Health. She completed Clinical Genetics fellowships at the University of Chicago Pritzker School of Medicine and is board certified in both Clinical Cytogenetics and Clinical Molecular Genetics by the American Board of Medical Genetics and Genomics (ABMGG). Her areas of responsibility include: clinical case sign out, CAP compliance and proficiency testing, and implementation of clinical laboratory screening/diagnostic assays. Dr. Reshmi is an Associate Professor (Clinical) in the departments of Pathology and Pediatrics at the Ohio State University College of Medicine and Co-Investigator of the Children’s Oncology Group (COG) Reference laboratory within the Biopathology Center, overseeing laboratory diagnostics for several COG disease disciplines.

See Shalini C. Reshmi’s Curriculum Vitae (CV)

Biography

Shalini Reshmi, PhD, received her doctoral degree from the University of Pittsburgh, Graduate School of Public Health. She completed Clinical Genetics fellowships at the University of Chicago Pritzker School of Medicine and is board certified in both Clinical Cytogenetics and Clinical Molecular Genetics by the American Board of Medical Genetics and Genomics (ABMGG). Her areas of responsibility include: clinical case sign out, CAP compliance and proficiency testing, and implementation of clinical laboratory screening/diagnostic assays. Dr. Reshmi is an Associate Professor (Clinical) in the departments of Pathology and Pediatrics at the Ohio State University College of Medicine and Co-Investigator of the Children’s Oncology Group (COG) Reference laboratory within the Biopathology Center, overseeing laboratory diagnostics for several COG disease disciplines.

See Shalini C. Reshmi’s Curriculum Vitae (CV)

Biography

Shalini Reshmi, PhD, received her doctoral degree from the University of Pittsburgh, Graduate School of Public Health. She completed Clinical Genetics fellowships at the University of Chicago Pritzker School of Medicine and is board certified in both Clinical Cytogenetics and Clinical Molecular Genetics by the American Board of Medical Genetics and Genomics (ABMGG). Her areas of responsibility include: clinical case sign out, CAP compliance and proficiency testing, and implementation of clinical laboratory screening/diagnostic assays. Dr. Reshmi is an Associate Professor (Clinical) in the departments of Pathology and Pediatrics at the Ohio State University College of Medicine and Co-Investigator of the Children’s Oncology Group (COG) Reference laboratory within the Biopathology Center, overseeing laboratory diagnostics for several COG disease disciplines.

See Shalini C. Reshmi’s Curriculum Vitae (CV)

Shalini Reshmi, PhD, received her doctoral degree from the University of Pittsburgh, Graduate School of Public Health. She completed Clinical Genetics fellowships at the University of Chicago Pritzker School of Medicine and is board certified in both Clinical Cytogenetics and Clinical Molecular Genetics by the American Board of Medical Genetics and Genomics (ABMGG). Her areas of responsibility include: clinical case sign out, CAP compliance and proficiency testing, and implementation of clinical laboratory screening/diagnostic assays. Dr. Reshmi is an Associate Professor (Clinical) in the departments of Pathology and Pediatrics at the Ohio State University College of Medicine and Co-Investigator of the Children’s Oncology Group (COG) Reference laboratory within the Biopathology Center, overseeing laboratory diagnostics for several COG disease disciplines.

See Shalini C. Reshmi’s Curriculum Vitae (CV)

Shalini Reshmi, PhD, received her doctoral degree from the University of Pittsburgh, Graduate School of Public Health. She completed Clinical Genetics fellowships at the University of Chicago Pritzker School of Medicine and is board certified in both Clinical Cytogenetics and Clinical Molecular Genetics by the American Board of Medical Genetics and Genomics (ABMGG). Her areas of responsibility include: clinical case sign out, CAP compliance and proficiency testing, and implementation of clinical laboratory screening/diagnostic assays. Dr. Reshmi is an Associate Professor (Clinical) in the departments of Pathology and Pediatrics at the Ohio State University College of Medicine and Co-Investigator of the Children’s Oncology Group (COG) Reference laboratory within the Biopathology Center, overseeing laboratory diagnostics for several COG disease disciplines.

See Shalini C. Reshmi’s Curriculum Vitae (CV)

Academic and Clinical Areas

Pathology Fellowship

Faculty

Pathology and Laboratory Medicine

Clinical Pathology Team

Clinical Pathology

Director, Institute for Genomic Medicine Clinical Laboratory

Primary Department

Institute for Genomic Medicine

Primary Section

Clinical Pathology

Academic and Clinical Areas

Pathology Fellowship

Faculty

Pathology and Laboratory Medicine

Clinical Pathology Team

Clinical Pathology

Director, Institute for Genomic Medicine Clinical Laboratory

Primary Department

Institute for Genomic Medicine

Primary Section

Clinical Pathology

Academic and Clinical Areas

Pathology Fellowship

Faculty

Pathology and Laboratory Medicine

Clinical Pathology Team

Clinical Pathology

Director, Institute for Genomic Medicine Clinical Laboratory

Primary Department

Institute for Genomic Medicine

Primary Section

Clinical Pathology

Pathology Fellowship

Faculty

Pathology and Laboratory Medicine

Clinical Pathology Team

Clinical Pathology

Director, Institute for Genomic Medicine Clinical Laboratory

Primary Department

Institute for Genomic Medicine

Primary Section

Clinical Pathology

• Pathology Fellowship
• Faculty
• Pathology and Laboratory Medicine
• Clinical Pathology Team
• Clinical Pathology
• Director, Institute for Genomic Medicine Clinical Laboratory
• Primary Department
• Institute for Genomic Medicine
• Primary Section
• Clinical Pathology

Awards, Honors & Organizations

Best Doctoral Dissertation, Human Genetics, Delta Omega National Honor Society, Omicron Chapter Pittsburgh, PA, 2005 Public Health Dean’s Scholarship Recipient, Outstanding Doctoral Student, University of Pittsburgh, 2004 Invited Participant, 3rd Annual St. Jude National Graduate Student Symposium, St. Jude Children’s Research Hospital, Memphis, TN, 2004 Member, ClinGen Somatic Cancer Variant Curation Expert Panel, 2022 - Present Member, Cancer Genome Consortium, 2018 - Present Member, American Society of Hematology, 2016 - Present Discipline Committee Chair, Laboratory Science,, Children’s Oncology Group, 2014 - Present CAP Inspector, Certified Molecular Pathology and Cytogenetics, 2011 - Present Fellow, American College of Medical Genetics and Genomics, 2009 - Present Member, Children’s Oncology Group, 2008 - Present Member, Association for Molecular Pathology, 2008 - Present Co-Investigator, Children’s Oncology Group, 2008 - Present Member, American College of Medical Genetics, 2007 - Present Member, American Society of Human Genetics, 2001 - Present Member, American Society of Human Genetics, 1994 - Present

Awards, Honors & Organizations

Best Doctoral Dissertation, Human Genetics, Delta Omega National Honor Society, Omicron Chapter Pittsburgh, PA, 2005 Public Health Dean’s Scholarship Recipient, Outstanding Doctoral Student, University of Pittsburgh, 2004 Invited Participant, 3rd Annual St. Jude National Graduate Student Symposium, St. Jude Children’s Research Hospital, Memphis, TN, 2004 Member, ClinGen Somatic Cancer Variant Curation Expert Panel, 2022 - Present Member, Cancer Genome Consortium, 2018 - Present Member, American Society of Hematology, 2016 - Present Discipline Committee Chair, Laboratory Science,, Children’s Oncology Group, 2014 - Present CAP Inspector, Certified Molecular Pathology and Cytogenetics, 2011 - Present Fellow, American College of Medical Genetics and Genomics, 2009 - Present Member, Children’s Oncology Group, 2008 - Present Member, Association for Molecular Pathology, 2008 - Present Co-Investigator, Children’s Oncology Group, 2008 - Present Member, American College of Medical Genetics, 2007 - Present Member, American Society of Human Genetics, 2001 - Present Member, American Society of Human Genetics, 1994 - Present

Awards, Honors & Organizations

Best Doctoral Dissertation, Human Genetics, Delta Omega National Honor Society, Omicron Chapter Pittsburgh, PA, 2005 Public Health Dean’s Scholarship Recipient, Outstanding Doctoral Student, University of Pittsburgh, 2004 Invited Participant, 3rd Annual St. Jude National Graduate Student Symposium, St. Jude Children’s Research Hospital, Memphis, TN, 2004 Member, ClinGen Somatic Cancer Variant Curation Expert Panel, 2022 - Present Member, Cancer Genome Consortium, 2018 - Present Member, American Society of Hematology, 2016 - Present Discipline Committee Chair, Laboratory Science,, Children’s Oncology Group, 2014 - Present CAP Inspector, Certified Molecular Pathology and Cytogenetics, 2011 - Present Fellow, American College of Medical Genetics and Genomics, 2009 - Present Member, Children’s Oncology Group, 2008 - Present Member, Association for Molecular Pathology, 2008 - Present Co-Investigator, Children’s Oncology Group, 2008 - Present Member, American College of Medical Genetics, 2007 - Present Member, American Society of Human Genetics, 2001 - Present Member, American Society of Human Genetics, 1994 - Present

Best Doctoral Dissertation, Human Genetics, Delta Omega National Honor Society, Omicron Chapter Pittsburgh, PA, 2005 Public Health Dean’s Scholarship Recipient, Outstanding Doctoral Student, University of Pittsburgh, 2004 Invited Participant, 3rd Annual St. Jude National Graduate Student Symposium, St. Jude Children’s Research Hospital, Memphis, TN, 2004 Member, ClinGen Somatic Cancer Variant Curation Expert Panel, 2022 - Present Member, Cancer Genome Consortium, 2018 - Present Member, American Society of Hematology, 2016 - Present Discipline Committee Chair, Laboratory Science,, Children’s Oncology Group, 2014 - Present CAP Inspector, Certified Molecular Pathology and Cytogenetics, 2011 - Present Fellow, American College of Medical Genetics and Genomics, 2009 - Present Member, Children’s Oncology Group, 2008 - Present Member, Association for Molecular Pathology, 2008 - Present Co-Investigator, Children’s Oncology Group, 2008 - Present Member, American College of Medical Genetics, 2007 - Present Member, American Society of Human Genetics, 2001 - Present Member, American Society of Human Genetics, 1994 - Present

• Best Doctoral Dissertation, Human Genetics, Delta Omega National Honor Society, Omicron Chapter Pittsburgh, PA, 2005
• Public Health Dean’s Scholarship Recipient, Outstanding Doctoral Student, University of Pittsburgh, 2004
• Invited Participant, 3rd Annual St. Jude National Graduate Student Symposium, St. Jude Children’s Research Hospital, Memphis, TN, 2004
• Member, ClinGen Somatic Cancer Variant Curation Expert Panel, 2022 - Present
• Member, Cancer Genome Consortium, 2018 - Present
• Member, American Society of Hematology, 2016 - Present
• Discipline Committee Chair, Laboratory Science,, Children’s Oncology Group, 2014 - Present
• CAP Inspector, Certified Molecular Pathology and Cytogenetics, 2011 - Present
• Fellow, American College of Medical Genetics and Genomics, 2009 - Present
• Member, Children’s Oncology Group, 2008 - Present
• Member, Association for Molecular Pathology, 2008 - Present
• Co-Investigator, Children’s Oncology Group, 2008 - Present
• Member, American College of Medical Genetics, 2007 - Present
• Member, American Society of Human Genetics, 2001 - Present
• Member, American Society of Human Genetics, 1994 - Present

Research

Interests

Translational Studies in Cancer Diagnostics

View My Publications Publications

                  Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, Parker M, Chen X, Elsayed AH, Pathak O, Li Y, Fan Y, Michael JR, Rusch M, Wilkinson MR, Foy S, Hedges DJ, Newman S, Zhou X, Wang J, Reilly C, Sioson E, Rice SV, Pastor Loyola V, Wu G, Rampersaud E, Reshmi SC, Gastier-Foster J, Guidry Auvil JM, Gesuwan P, Smith MA, Winick N, Carroll AJ, Heerema NA, Harvey RC, Willman CL, Larsen E, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Winter SS, Burke MJ, Salzer W, Dunsmore KP, Angiolillo AL, Crews KR, Downing JR, Jeha S, Pui CH, Evans WE, Yang JJ, Relling MV, Gerhard DS, Loh ML, Hunger SP, Zhang J, Mullighan CG. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet. 2022 Sep; 54: 1376-1389.

                


                  Mathew MT, Antoniou A, Ramesh N, Hu M, Gaither J, Mouhlas D, Hashimoto S, Humphrey M, Matthews T, Hunter JM, Reshmi S, Schultz M, Lee K, Pfau R, Cottrell C, McBride KL, Navin NE, Chaudhari BP, Leung ML. A Decade's Experience in Pediatric Chromosomal Microarray Reveals Distinct Characteristics Across Ordering Specialties. J Mol Diagn. 2022 Jun 16;  

                


                  Yang H, Zhang H, Luan Y, Liu T, Yang W, Roberts KG, Qian MX, Zhang B, Yang W, Perez-Andreu V, Xu J, Iyyanki S, Kuang D, Stasiak LA, Reshmi SC, Gastier-Foster J, Smith C, Pui CH, Evans WE, Hunger SP, Platanias LC, Relling MV, Mullighan CG, Loh ML, Yue F, Yang JJ. Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation. Nat Genet. 2022 Feb; 54: 170-179.

                


                  Hunter JM, Massingham LJ, Manickam K, Bartholomew D, Williamson RK, Schwab JL, Marhabaie M, Siemon A, de Los Reyes E, Reshmi SC, Cottrell CE, Wilson RK, Koboldt DC. Inherited and de novo variants extend the etiology of TAOK1-associated neurodevelopmental disorder. Cold Spring Harb Mol Case Stud. 2022 Feb; 8: 

                


                  Irwin MS, Naranjo A, Zhang FF, Cohn SL, London WB, Gastier-Foster JM, Ramirez NC, Pfau R, Reshmi S, Wagner E, Nuchtern J, Asgharzadeh S, Shimada H, Maris JM, Bagatell R, Park JR, Hogarty MD. Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group. J Clin Oncol. 2021 Oct 10; 39: 3229-3241.

                


                  Kraft MT, Mehyar LS, Prince BT, Reshmi SC, Abraham RS, Abu-Arja R. Immune Reconstitution after Hematopoietic Stem Cell Transplantation in Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome Type 1. J Clin Immunol. 2021 Jul; 41: 1089-1094.

                


                  Akhavanfard S, Nohr E, AlNajjar M, Haughn M, Hashimoto S, Deeg C, Pfau R, Brundler MA, Reshmi SC. 5' ALK Amplification in Neuroblastoma: A Case Report. Case Rep Oncol. 2021 Jan-Apr; 14: 585-591.

                


                  Pfeifer H, Cazzaniga G, van der Velden VHJ, Cayuela JM, Schäfer B, Spinelli O, Akiki S, Avigad S, Bendit I, Borg K, Cavé H, Elia L, Reshmi SC, Gerrard G, Hayette S, Hermanson M, Juh A, Jurcek T, Chillón MC, Homburg C, Martinelli G, Kairisto V, Lange T, Lion T, Mueller MC, Pane F, Rai L, Damm-Welk C, Sacha T, Schnittger S, Touloumenidou T, Valerhaugen H, Vandenberghe P, Zuna J, Serve H, Herrmann E, Markovic S, Dongen JJMV, Ottmann OG. Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph?+?ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1. Leukemia. 2019 Aug; 33: 1910-1922.

                


                  Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, Devidas M, Dai Y, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mrózek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans WE, Jeha S, Pui CH, Yang J, Paietta E, Downing JR, Relling MV, Zhang J, Loh ML, Hunger SP, Mullighan CG. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019 Feb; 51: 296-307.

                


                  Roberts KG, Reshmi SC, Harvey RC, Chen IM, Patel K, Stonerock E, Jenkins H, Dai Y, Valentine M, Gu Z, Zhao Y, Zhang J, Payne-Turner D, Devidas M, Heerema NA, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Mattano LA Jr, Maloney KW, Carroll WL, Loh ML, Willman CL, Gastier-Foster JM, Mullighan CG, Hunger SP. Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group. Blood. 2018 Aug 23; 132: 815-824.

                


                  Barrie ES, Li Y, Lamb-Thrush D, Hashimoto S, Matthews T, Mouhlas D, Pyatt R, Reshmi SC, Gastier-Foster JM, Pfau R, Astbury C. Pericentromeric regions of homozygosity on the X chromosome: Another likely benign population variant. Eur J Med Genet. 2018 Jul; 61: 416-420.

                


                  Tran TH, Harris MH, Nguyen JV, Blonquist TM, Stevenson KE, Stonerock E, Asselin BL, Athale UH, Clavell LA, Cole PD, Kelly KM, Laverdiere C, Leclerc JM, Michon B, Schorin MA, Welch JJG, Reshmi SC, Neuberg DS, Sallan SE, Loh ML, Silverman LB. Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia. Blood Adv. 2018 Mar 13; 2: 529-533.

                


                  Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group. Blood. 2017 Jun 22; 129: 3352-3361.

View More Publications

Research

Interests

Translational Studies in Cancer Diagnostics

View My Publications Publications

                  Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, Parker M, Chen X, Elsayed AH, Pathak O, Li Y, Fan Y, Michael JR, Rusch M, Wilkinson MR, Foy S, Hedges DJ, Newman S, Zhou X, Wang J, Reilly C, Sioson E, Rice SV, Pastor Loyola V, Wu G, Rampersaud E, Reshmi SC, Gastier-Foster J, Guidry Auvil JM, Gesuwan P, Smith MA, Winick N, Carroll AJ, Heerema NA, Harvey RC, Willman CL, Larsen E, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Winter SS, Burke MJ, Salzer W, Dunsmore KP, Angiolillo AL, Crews KR, Downing JR, Jeha S, Pui CH, Evans WE, Yang JJ, Relling MV, Gerhard DS, Loh ML, Hunger SP, Zhang J, Mullighan CG. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet. 2022 Sep; 54: 1376-1389.

                


                  Mathew MT, Antoniou A, Ramesh N, Hu M, Gaither J, Mouhlas D, Hashimoto S, Humphrey M, Matthews T, Hunter JM, Reshmi S, Schultz M, Lee K, Pfau R, Cottrell C, McBride KL, Navin NE, Chaudhari BP, Leung ML. A Decade's Experience in Pediatric Chromosomal Microarray Reveals Distinct Characteristics Across Ordering Specialties. J Mol Diagn. 2022 Jun 16;  

                


                  Yang H, Zhang H, Luan Y, Liu T, Yang W, Roberts KG, Qian MX, Zhang B, Yang W, Perez-Andreu V, Xu J, Iyyanki S, Kuang D, Stasiak LA, Reshmi SC, Gastier-Foster J, Smith C, Pui CH, Evans WE, Hunger SP, Platanias LC, Relling MV, Mullighan CG, Loh ML, Yue F, Yang JJ. Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation. Nat Genet. 2022 Feb; 54: 170-179.

                


                  Hunter JM, Massingham LJ, Manickam K, Bartholomew D, Williamson RK, Schwab JL, Marhabaie M, Siemon A, de Los Reyes E, Reshmi SC, Cottrell CE, Wilson RK, Koboldt DC. Inherited and de novo variants extend the etiology of TAOK1-associated neurodevelopmental disorder. Cold Spring Harb Mol Case Stud. 2022 Feb; 8: 

                


                  Irwin MS, Naranjo A, Zhang FF, Cohn SL, London WB, Gastier-Foster JM, Ramirez NC, Pfau R, Reshmi S, Wagner E, Nuchtern J, Asgharzadeh S, Shimada H, Maris JM, Bagatell R, Park JR, Hogarty MD. Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group. J Clin Oncol. 2021 Oct 10; 39: 3229-3241.

                


                  Kraft MT, Mehyar LS, Prince BT, Reshmi SC, Abraham RS, Abu-Arja R. Immune Reconstitution after Hematopoietic Stem Cell Transplantation in Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome Type 1. J Clin Immunol. 2021 Jul; 41: 1089-1094.

                


                  Akhavanfard S, Nohr E, AlNajjar M, Haughn M, Hashimoto S, Deeg C, Pfau R, Brundler MA, Reshmi SC. 5' ALK Amplification in Neuroblastoma: A Case Report. Case Rep Oncol. 2021 Jan-Apr; 14: 585-591.

                


                  Pfeifer H, Cazzaniga G, van der Velden VHJ, Cayuela JM, Schäfer B, Spinelli O, Akiki S, Avigad S, Bendit I, Borg K, Cavé H, Elia L, Reshmi SC, Gerrard G, Hayette S, Hermanson M, Juh A, Jurcek T, Chillón MC, Homburg C, Martinelli G, Kairisto V, Lange T, Lion T, Mueller MC, Pane F, Rai L, Damm-Welk C, Sacha T, Schnittger S, Touloumenidou T, Valerhaugen H, Vandenberghe P, Zuna J, Serve H, Herrmann E, Markovic S, Dongen JJMV, Ottmann OG. Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph?+?ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1. Leukemia. 2019 Aug; 33: 1910-1922.

                


                  Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, Devidas M, Dai Y, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mrózek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans WE, Jeha S, Pui CH, Yang J, Paietta E, Downing JR, Relling MV, Zhang J, Loh ML, Hunger SP, Mullighan CG. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019 Feb; 51: 296-307.

                


                  Roberts KG, Reshmi SC, Harvey RC, Chen IM, Patel K, Stonerock E, Jenkins H, Dai Y, Valentine M, Gu Z, Zhao Y, Zhang J, Payne-Turner D, Devidas M, Heerema NA, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Mattano LA Jr, Maloney KW, Carroll WL, Loh ML, Willman CL, Gastier-Foster JM, Mullighan CG, Hunger SP. Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group. Blood. 2018 Aug 23; 132: 815-824.

                


                  Barrie ES, Li Y, Lamb-Thrush D, Hashimoto S, Matthews T, Mouhlas D, Pyatt R, Reshmi SC, Gastier-Foster JM, Pfau R, Astbury C. Pericentromeric regions of homozygosity on the X chromosome: Another likely benign population variant. Eur J Med Genet. 2018 Jul; 61: 416-420.

                


                  Tran TH, Harris MH, Nguyen JV, Blonquist TM, Stevenson KE, Stonerock E, Asselin BL, Athale UH, Clavell LA, Cole PD, Kelly KM, Laverdiere C, Leclerc JM, Michon B, Schorin MA, Welch JJG, Reshmi SC, Neuberg DS, Sallan SE, Loh ML, Silverman LB. Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia. Blood Adv. 2018 Mar 13; 2: 529-533.

                


                  Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group. Blood. 2017 Jun 22; 129: 3352-3361.

View More Publications

Research

Interests

Translational Studies in Cancer Diagnostics

View My Publications Publications

                  Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, Parker M, Chen X, Elsayed AH, Pathak O, Li Y, Fan Y, Michael JR, Rusch M, Wilkinson MR, Foy S, Hedges DJ, Newman S, Zhou X, Wang J, Reilly C, Sioson E, Rice SV, Pastor Loyola V, Wu G, Rampersaud E, Reshmi SC, Gastier-Foster J, Guidry Auvil JM, Gesuwan P, Smith MA, Winick N, Carroll AJ, Heerema NA, Harvey RC, Willman CL, Larsen E, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Winter SS, Burke MJ, Salzer W, Dunsmore KP, Angiolillo AL, Crews KR, Downing JR, Jeha S, Pui CH, Evans WE, Yang JJ, Relling MV, Gerhard DS, Loh ML, Hunger SP, Zhang J, Mullighan CG. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet. 2022 Sep; 54: 1376-1389.

                


                  Mathew MT, Antoniou A, Ramesh N, Hu M, Gaither J, Mouhlas D, Hashimoto S, Humphrey M, Matthews T, Hunter JM, Reshmi S, Schultz M, Lee K, Pfau R, Cottrell C, McBride KL, Navin NE, Chaudhari BP, Leung ML. A Decade's Experience in Pediatric Chromosomal Microarray Reveals Distinct Characteristics Across Ordering Specialties. J Mol Diagn. 2022 Jun 16;  

                


                  Yang H, Zhang H, Luan Y, Liu T, Yang W, Roberts KG, Qian MX, Zhang B, Yang W, Perez-Andreu V, Xu J, Iyyanki S, Kuang D, Stasiak LA, Reshmi SC, Gastier-Foster J, Smith C, Pui CH, Evans WE, Hunger SP, Platanias LC, Relling MV, Mullighan CG, Loh ML, Yue F, Yang JJ. Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation. Nat Genet. 2022 Feb; 54: 170-179.

                


                  Hunter JM, Massingham LJ, Manickam K, Bartholomew D, Williamson RK, Schwab JL, Marhabaie M, Siemon A, de Los Reyes E, Reshmi SC, Cottrell CE, Wilson RK, Koboldt DC. Inherited and de novo variants extend the etiology of TAOK1-associated neurodevelopmental disorder. Cold Spring Harb Mol Case Stud. 2022 Feb; 8: 

                


                  Irwin MS, Naranjo A, Zhang FF, Cohn SL, London WB, Gastier-Foster JM, Ramirez NC, Pfau R, Reshmi S, Wagner E, Nuchtern J, Asgharzadeh S, Shimada H, Maris JM, Bagatell R, Park JR, Hogarty MD. Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group. J Clin Oncol. 2021 Oct 10; 39: 3229-3241.

                


                  Kraft MT, Mehyar LS, Prince BT, Reshmi SC, Abraham RS, Abu-Arja R. Immune Reconstitution after Hematopoietic Stem Cell Transplantation in Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome Type 1. J Clin Immunol. 2021 Jul; 41: 1089-1094.

                


                  Akhavanfard S, Nohr E, AlNajjar M, Haughn M, Hashimoto S, Deeg C, Pfau R, Brundler MA, Reshmi SC. 5' ALK Amplification in Neuroblastoma: A Case Report. Case Rep Oncol. 2021 Jan-Apr; 14: 585-591.

                


                  Pfeifer H, Cazzaniga G, van der Velden VHJ, Cayuela JM, Schäfer B, Spinelli O, Akiki S, Avigad S, Bendit I, Borg K, Cavé H, Elia L, Reshmi SC, Gerrard G, Hayette S, Hermanson M, Juh A, Jurcek T, Chillón MC, Homburg C, Martinelli G, Kairisto V, Lange T, Lion T, Mueller MC, Pane F, Rai L, Damm-Welk C, Sacha T, Schnittger S, Touloumenidou T, Valerhaugen H, Vandenberghe P, Zuna J, Serve H, Herrmann E, Markovic S, Dongen JJMV, Ottmann OG. Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph?+?ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1. Leukemia. 2019 Aug; 33: 1910-1922.

                


                  Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, Devidas M, Dai Y, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mrózek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans WE, Jeha S, Pui CH, Yang J, Paietta E, Downing JR, Relling MV, Zhang J, Loh ML, Hunger SP, Mullighan CG. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019 Feb; 51: 296-307.

                


                  Roberts KG, Reshmi SC, Harvey RC, Chen IM, Patel K, Stonerock E, Jenkins H, Dai Y, Valentine M, Gu Z, Zhao Y, Zhang J, Payne-Turner D, Devidas M, Heerema NA, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Mattano LA Jr, Maloney KW, Carroll WL, Loh ML, Willman CL, Gastier-Foster JM, Mullighan CG, Hunger SP. Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group. Blood. 2018 Aug 23; 132: 815-824.

                


                  Barrie ES, Li Y, Lamb-Thrush D, Hashimoto S, Matthews T, Mouhlas D, Pyatt R, Reshmi SC, Gastier-Foster JM, Pfau R, Astbury C. Pericentromeric regions of homozygosity on the X chromosome: Another likely benign population variant. Eur J Med Genet. 2018 Jul; 61: 416-420.

                


                  Tran TH, Harris MH, Nguyen JV, Blonquist TM, Stevenson KE, Stonerock E, Asselin BL, Athale UH, Clavell LA, Cole PD, Kelly KM, Laverdiere C, Leclerc JM, Michon B, Schorin MA, Welch JJG, Reshmi SC, Neuberg DS, Sallan SE, Loh ML, Silverman LB. Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia. Blood Adv. 2018 Mar 13; 2: 529-533.

                


                  Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group. Blood. 2017 Jun 22; 129: 3352-3361.

View More Publications

Interests

Translational Studies in Cancer Diagnostics

View My Publications Publications

                  Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, Parker M, Chen X, Elsayed AH, Pathak O, Li Y, Fan Y, Michael JR, Rusch M, Wilkinson MR, Foy S, Hedges DJ, Newman S, Zhou X, Wang J, Reilly C, Sioson E, Rice SV, Pastor Loyola V, Wu G, Rampersaud E, Reshmi SC, Gastier-Foster J, Guidry Auvil JM, Gesuwan P, Smith MA, Winick N, Carroll AJ, Heerema NA, Harvey RC, Willman CL, Larsen E, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Winter SS, Burke MJ, Salzer W, Dunsmore KP, Angiolillo AL, Crews KR, Downing JR, Jeha S, Pui CH, Evans WE, Yang JJ, Relling MV, Gerhard DS, Loh ML, Hunger SP, Zhang J, Mullighan CG. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet. 2022 Sep; 54: 1376-1389.

                


                  Mathew MT, Antoniou A, Ramesh N, Hu M, Gaither J, Mouhlas D, Hashimoto S, Humphrey M, Matthews T, Hunter JM, Reshmi S, Schultz M, Lee K, Pfau R, Cottrell C, McBride KL, Navin NE, Chaudhari BP, Leung ML. A Decade's Experience in Pediatric Chromosomal Microarray Reveals Distinct Characteristics Across Ordering Specialties. J Mol Diagn. 2022 Jun 16;  

                


                  Yang H, Zhang H, Luan Y, Liu T, Yang W, Roberts KG, Qian MX, Zhang B, Yang W, Perez-Andreu V, Xu J, Iyyanki S, Kuang D, Stasiak LA, Reshmi SC, Gastier-Foster J, Smith C, Pui CH, Evans WE, Hunger SP, Platanias LC, Relling MV, Mullighan CG, Loh ML, Yue F, Yang JJ. Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation. Nat Genet. 2022 Feb; 54: 170-179.

                


                  Hunter JM, Massingham LJ, Manickam K, Bartholomew D, Williamson RK, Schwab JL, Marhabaie M, Siemon A, de Los Reyes E, Reshmi SC, Cottrell CE, Wilson RK, Koboldt DC. Inherited and de novo variants extend the etiology of TAOK1-associated neurodevelopmental disorder. Cold Spring Harb Mol Case Stud. 2022 Feb; 8: 

                


                  Irwin MS, Naranjo A, Zhang FF, Cohn SL, London WB, Gastier-Foster JM, Ramirez NC, Pfau R, Reshmi S, Wagner E, Nuchtern J, Asgharzadeh S, Shimada H, Maris JM, Bagatell R, Park JR, Hogarty MD. Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group. J Clin Oncol. 2021 Oct 10; 39: 3229-3241.

                


                  Kraft MT, Mehyar LS, Prince BT, Reshmi SC, Abraham RS, Abu-Arja R. Immune Reconstitution after Hematopoietic Stem Cell Transplantation in Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome Type 1. J Clin Immunol. 2021 Jul; 41: 1089-1094.

                


                  Akhavanfard S, Nohr E, AlNajjar M, Haughn M, Hashimoto S, Deeg C, Pfau R, Brundler MA, Reshmi SC. 5' ALK Amplification in Neuroblastoma: A Case Report. Case Rep Oncol. 2021 Jan-Apr; 14: 585-591.

                


                  Pfeifer H, Cazzaniga G, van der Velden VHJ, Cayuela JM, Schäfer B, Spinelli O, Akiki S, Avigad S, Bendit I, Borg K, Cavé H, Elia L, Reshmi SC, Gerrard G, Hayette S, Hermanson M, Juh A, Jurcek T, Chillón MC, Homburg C, Martinelli G, Kairisto V, Lange T, Lion T, Mueller MC, Pane F, Rai L, Damm-Welk C, Sacha T, Schnittger S, Touloumenidou T, Valerhaugen H, Vandenberghe P, Zuna J, Serve H, Herrmann E, Markovic S, Dongen JJMV, Ottmann OG. Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph?+?ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1. Leukemia. 2019 Aug; 33: 1910-1922.

                


                  Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, Devidas M, Dai Y, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mrózek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans WE, Jeha S, Pui CH, Yang J, Paietta E, Downing JR, Relling MV, Zhang J, Loh ML, Hunger SP, Mullighan CG. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019 Feb; 51: 296-307.

                


                  Roberts KG, Reshmi SC, Harvey RC, Chen IM, Patel K, Stonerock E, Jenkins H, Dai Y, Valentine M, Gu Z, Zhao Y, Zhang J, Payne-Turner D, Devidas M, Heerema NA, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Mattano LA Jr, Maloney KW, Carroll WL, Loh ML, Willman CL, Gastier-Foster JM, Mullighan CG, Hunger SP. Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group. Blood. 2018 Aug 23; 132: 815-824.

                


                  Barrie ES, Li Y, Lamb-Thrush D, Hashimoto S, Matthews T, Mouhlas D, Pyatt R, Reshmi SC, Gastier-Foster JM, Pfau R, Astbury C. Pericentromeric regions of homozygosity on the X chromosome: Another likely benign population variant. Eur J Med Genet. 2018 Jul; 61: 416-420.

                


                  Tran TH, Harris MH, Nguyen JV, Blonquist TM, Stevenson KE, Stonerock E, Asselin BL, Athale UH, Clavell LA, Cole PD, Kelly KM, Laverdiere C, Leclerc JM, Michon B, Schorin MA, Welch JJG, Reshmi SC, Neuberg DS, Sallan SE, Loh ML, Silverman LB. Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia. Blood Adv. 2018 Mar 13; 2: 529-533.

                


                  Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group. Blood. 2017 Jun 22; 129: 3352-3361.

View More Publications

Interests

Translational Studies in Cancer Diagnostics

View My Publications

Interests

Translational Studies in Cancer Diagnostics

• Translational Studies in Cancer Diagnostics

                  Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, Parker M, Chen X, Elsayed AH, Pathak O, Li Y, Fan Y, Michael JR, Rusch M, Wilkinson MR, Foy S, Hedges DJ, Newman S, Zhou X, Wang J, Reilly C, Sioson E, Rice SV, Pastor Loyola V, Wu G, Rampersaud E, Reshmi SC, Gastier-Foster J, Guidry Auvil JM, Gesuwan P, Smith MA, Winick N, Carroll AJ, Heerema NA, Harvey RC, Willman CL, Larsen E, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Winter SS, Burke MJ, Salzer W, Dunsmore KP, Angiolillo AL, Crews KR, Downing JR, Jeha S, Pui CH, Evans WE, Yang JJ, Relling MV, Gerhard DS, Loh ML, Hunger SP, Zhang J, Mullighan CG. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet. 2022 Sep; 54: 1376-1389.
  
  
  
                  Mathew MT, Antoniou A, Ramesh N, Hu M, Gaither J, Mouhlas D, Hashimoto S, Humphrey M, Matthews T, Hunter JM, Reshmi S, Schultz M, Lee K, Pfau R, Cottrell C, McBride KL, Navin NE, Chaudhari BP, Leung ML. A Decade's Experience in Pediatric Chromosomal Microarray Reveals Distinct Characteristics Across Ordering Specialties. J Mol Diagn. 2022 Jun 16;  
  
  
  
                  Yang H, Zhang H, Luan Y, Liu T, Yang W, Roberts KG, Qian MX, Zhang B, Yang W, Perez-Andreu V, Xu J, Iyyanki S, Kuang D, Stasiak LA, Reshmi SC, Gastier-Foster J, Smith C, Pui CH, Evans WE, Hunger SP, Platanias LC, Relling MV, Mullighan CG, Loh ML, Yue F, Yang JJ. Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation. Nat Genet. 2022 Feb; 54: 170-179.
  
  
  
                  Hunter JM, Massingham LJ, Manickam K, Bartholomew D, Williamson RK, Schwab JL, Marhabaie M, Siemon A, de Los Reyes E, Reshmi SC, Cottrell CE, Wilson RK, Koboldt DC. Inherited and de novo variants extend the etiology of TAOK1-associated neurodevelopmental disorder. Cold Spring Harb Mol Case Stud. 2022 Feb; 8: 
  
  
  
                  Irwin MS, Naranjo A, Zhang FF, Cohn SL, London WB, Gastier-Foster JM, Ramirez NC, Pfau R, Reshmi S, Wagner E, Nuchtern J, Asgharzadeh S, Shimada H, Maris JM, Bagatell R, Park JR, Hogarty MD. Revised Neuroblastoma Risk Classification System: A Report From the Children's Oncology Group. J Clin Oncol. 2021 Oct 10; 39: 3229-3241.
  
  
  
                  Kraft MT, Mehyar LS, Prince BT, Reshmi SC, Abraham RS, Abu-Arja R. Immune Reconstitution after Hematopoietic Stem Cell Transplantation in Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome Type 1. J Clin Immunol. 2021 Jul; 41: 1089-1094.
  
  
  
                  Akhavanfard S, Nohr E, AlNajjar M, Haughn M, Hashimoto S, Deeg C, Pfau R, Brundler MA, Reshmi SC. 5' ALK Amplification in Neuroblastoma: A Case Report. Case Rep Oncol. 2021 Jan-Apr; 14: 585-591.
  
  
  
                  Pfeifer H, Cazzaniga G, van der Velden VHJ, Cayuela JM, Schäfer B, Spinelli O, Akiki S, Avigad S, Bendit I, Borg K, Cavé H, Elia L, Reshmi SC, Gerrard G, Hayette S, Hermanson M, Juh A, Jurcek T, Chillón MC, Homburg C, Martinelli G, Kairisto V, Lange T, Lion T, Mueller MC, Pane F, Rai L, Damm-Welk C, Sacha T, Schnittger S, Touloumenidou T, Valerhaugen H, Vandenberghe P, Zuna J, Serve H, Herrmann E, Markovic S, Dongen JJMV, Ottmann OG. Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph?+?ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1. Leukemia. 2019 Aug; 33: 1910-1922.
  
  
  
                  Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, Devidas M, Dai Y, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mrózek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans WE, Jeha S, Pui CH, Yang J, Paietta E, Downing JR, Relling MV, Zhang J, Loh ML, Hunger SP, Mullighan CG. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019 Feb; 51: 296-307.
  
  
  
                  Roberts KG, Reshmi SC, Harvey RC, Chen IM, Patel K, Stonerock E, Jenkins H, Dai Y, Valentine M, Gu Z, Zhao Y, Zhang J, Payne-Turner D, Devidas M, Heerema NA, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Mattano LA Jr, Maloney KW, Carroll WL, Loh ML, Willman CL, Gastier-Foster JM, Mullighan CG, Hunger SP. Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children's Oncology Group. Blood. 2018 Aug 23; 132: 815-824.
  
  
  
                  Barrie ES, Li Y, Lamb-Thrush D, Hashimoto S, Matthews T, Mouhlas D, Pyatt R, Reshmi SC, Gastier-Foster JM, Pfau R, Astbury C. Pericentromeric regions of homozygosity on the X chromosome: Another likely benign population variant. Eur J Med Genet. 2018 Jul; 61: 416-420.
  
  
  
                  Tran TH, Harris MH, Nguyen JV, Blonquist TM, Stevenson KE, Stonerock E, Asselin BL, Athale UH, Clavell LA, Cole PD, Kelly KM, Laverdiere C, Leclerc JM, Michon B, Schorin MA, Welch JJG, Reshmi SC, Neuberg DS, Sallan SE, Loh ML, Silverman LB. Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia. Blood Adv. 2018 Mar 13; 2: 529-533.
  
  
  
                  Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group. Blood. 2017 Jun 22; 129: 3352-3361.
  
  

View More Publications

• Brady SW, Roberts KG, Gu Z, Shi L, Pounds S, Pei D, Cheng C, Dai Y, Devidas M, Qu C, Hill AN, Payne-Turner D, Ma X, Iacobucci I, Baviskar P, Wei L, Arunachalam S, Hagiwara K, Liu Y, Flasch DA, Liu Y, Parker M, Chen X, Elsayed AH, Pathak O, Li Y, Fan Y, Michael JR, Rusch M, Wilkinson MR, Foy S, Hedges DJ, Newman S, Zhou X, Wang J, Reilly C, Sioson E, Rice SV, Pastor Loyola V, Wu G, Rampersaud E, Reshmi SC, Gastier-Foster J, Guidry Auvil JM, Gesuwan P, Smith MA, Winick N, Carroll AJ, Heerema NA, Harvey RC, Willman CL, Larsen E, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Winter SS, Burke MJ, Salzer W, Dunsmore KP, Angiolillo AL, Crews KR, Downing JR, Jeha S, Pui CH, Evans WE, Yang JJ, Relling MV, Gerhard DS, Loh ML, Hunger SP, Zhang J, Mullighan CG. The genomic landscape of pediatric acute lymphoblastic leukemia. Nat Genet. 2022 Sep; 54: 1376-1389.
• Mathew MT, Antoniou A, Ramesh N, Hu M, Gaither J, Mouhlas D, Hashimoto S, Humphrey M, Matthews T, Hunter JM, Reshmi S, Schultz M, Lee K, Pfau R, Cottrell C, McBride KL, Navin NE, Chaudhari BP, Leung ML. A Decade’s Experience in Pediatric Chromosomal Microarray Reveals Distinct Characteristics Across Ordering Specialties. J Mol Diagn. 2022 Jun 16;
• Yang H, Zhang H, Luan Y, Liu T, Yang W, Roberts KG, Qian MX, Zhang B, Yang W, Perez-Andreu V, Xu J, Iyyanki S, Kuang D, Stasiak LA, Reshmi SC, Gastier-Foster J, Smith C, Pui CH, Evans WE, Hunger SP, Platanias LC, Relling MV, Mullighan CG, Loh ML, Yue F, Yang JJ. Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation. Nat Genet. 2022 Feb; 54: 170-179.
• Hunter JM, Massingham LJ, Manickam K, Bartholomew D, Williamson RK, Schwab JL, Marhabaie M, Siemon A, de Los Reyes E, Reshmi SC, Cottrell CE, Wilson RK, Koboldt DC. Inherited and de novo variants extend the etiology of TAOK1-associated neurodevelopmental disorder. Cold Spring Harb Mol Case Stud. 2022 Feb; 8:
• Irwin MS, Naranjo A, Zhang FF, Cohn SL, London WB, Gastier-Foster JM, Ramirez NC, Pfau R, Reshmi S, Wagner E, Nuchtern J, Asgharzadeh S, Shimada H, Maris JM, Bagatell R, Park JR, Hogarty MD. Revised Neuroblastoma Risk Classification System: A Report From the Children’s Oncology Group. J Clin Oncol. 2021 Oct 10; 39: 3229-3241.
• Kraft MT, Mehyar LS, Prince BT, Reshmi SC, Abraham RS, Abu-Arja R. Immune Reconstitution after Hematopoietic Stem Cell Transplantation in Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome Type 1. J Clin Immunol. 2021 Jul; 41: 1089-1094.
• Akhavanfard S, Nohr E, AlNajjar M, Haughn M, Hashimoto S, Deeg C, Pfau R, Brundler MA, Reshmi SC. 5’ ALK Amplification in Neuroblastoma: A Case Report. Case Rep Oncol. 2021 Jan-Apr; 14: 585-591.
• Pfeifer H, Cazzaniga G, van der Velden VHJ, Cayuela JM, Schäfer B, Spinelli O, Akiki S, Avigad S, Bendit I, Borg K, Cavé H, Elia L, Reshmi SC, Gerrard G, Hayette S, Hermanson M, Juh A, Jurcek T, Chillón MC, Homburg C, Martinelli G, Kairisto V, Lange T, Lion T, Mueller MC, Pane F, Rai L, Damm-Welk C, Sacha T, Schnittger S, Touloumenidou T, Valerhaugen H, Vandenberghe P, Zuna J, Serve H, Herrmann E, Markovic S, Dongen JJMV, Ottmann OG. Standardisation and consensus guidelines for minimal residual disease assessment in Philadelphia-positive acute lymphoblastic leukemia (Ph?+?ALL) by real-time quantitative reverse transcriptase PCR of e1a2 BCR-ABL1. Leukemia. 2019 Aug; 33: 1910-1922.
• Gu Z, Churchman ML, Roberts KG, Moore I, Zhou X, Nakitandwe J, Hagiwara K, Pelletier S, Gingras S, Berns H, Payne-Turner D, Hill A, Iacobucci I, Shi L, Pounds S, Cheng C, Pei D, Qu C, Newman S, Devidas M, Dai Y, Reshmi SC, Gastier-Foster J, Raetz EA, Borowitz MJ, Wood BL, Carroll WL, Zweidler-McKay PA, Rabin KR, Mattano LA, Maloney KW, Rambaldi A, Spinelli O, Radich JP, Minden MD, Rowe JM, Luger S, Litzow MR, Tallman MS, Racevskis J, Zhang Y, Bhatia R, Kohlschmidt J, Mrózek K, Bloomfield CD, Stock W, Kornblau S, Kantarjian HM, Konopleva M, Evans WE, Jeha S, Pui CH, Yang J, Paietta E, Downing JR, Relling MV, Zhang J, Loh ML, Hunger SP, Mullighan CG. PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia. Nat Genet. 2019 Feb; 51: 296-307.
• Roberts KG, Reshmi SC, Harvey RC, Chen IM, Patel K, Stonerock E, Jenkins H, Dai Y, Valentine M, Gu Z, Zhao Y, Zhang J, Payne-Turner D, Devidas M, Heerema NA, Carroll AJ, Raetz EA, Borowitz MJ, Wood BL, Mattano LA Jr, Maloney KW, Carroll WL, Loh ML, Willman CL, Gastier-Foster JM, Mullighan CG, Hunger SP. Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children’s Oncology Group. Blood. 2018 Aug 23; 132: 815-824.
• Barrie ES, Li Y, Lamb-Thrush D, Hashimoto S, Matthews T, Mouhlas D, Pyatt R, Reshmi SC, Gastier-Foster JM, Pfau R, Astbury C. Pericentromeric regions of homozygosity on the X chromosome: Another likely benign population variant. Eur J Med Genet. 2018 Jul; 61: 416-420.
• Tran TH, Harris MH, Nguyen JV, Blonquist TM, Stevenson KE, Stonerock E, Asselin BL, Athale UH, Clavell LA, Cole PD, Kelly KM, Laverdiere C, Leclerc JM, Michon B, Schorin MA, Welch JJG, Reshmi SC, Neuberg DS, Sallan SE, Loh ML, Silverman LB. Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia. Blood Adv. 2018 Mar 13; 2: 529-533.
• Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP. Targetable kinase gene fusions in high-risk B-ALL: a study from the Children’s Oncology Group. Blood. 2017 Jun 22; 129: 3352-3361.

Clinical Interests

Neuroblastoma Ph-like Acute Lymphoblastic Leukemia Wilms Tumor

Clinical Interests

Neuroblastoma Ph-like Acute Lymphoblastic Leukemia Wilms Tumor

Clinical Interests

Neuroblastoma Ph-like Acute Lymphoblastic Leukemia Wilms Tumor

Neuroblastoma Ph-like Acute Lymphoblastic Leukemia Wilms Tumor

• Neuroblastoma
• Ph-like Acute Lymphoblastic Leukemia
• Wilms Tumor

Professional Experience

2008 - Present (Clinical)Pathology, The Ohio State University, Assistant Professor2008 - Present Nationwide Children’s Hospital, Department of Laboratory Medicine, Assistant Director of the Cytogenetics and Molecular Genetics Laboratories2008 - Present The Research Institute at Nationwide Children’s Hospital, Assistant Director of the Children’s Oncology Group Reference Laboratory2005 - 2008 Clinical Cytogenetics and Molecular Genetics, Fellow2001 - 2005 Cancer Cytogenetics; The University of Pittsburgh, Graduate Student Researcher2001 - 2001 Cytogenetics Facility; University of Pittsburgh Cancer Institute and Center for Human Genetics and Integrative Biology, Supervisor1999 - 2001 Allegheny General Hospital, Cytogenetic Technologist

Professional Experience

2008 - Present (Clinical)Pathology, The Ohio State University, Assistant Professor2008 - Present Nationwide Children’s Hospital, Department of Laboratory Medicine, Assistant Director of the Cytogenetics and Molecular Genetics Laboratories2008 - Present The Research Institute at Nationwide Children’s Hospital, Assistant Director of the Children’s Oncology Group Reference Laboratory2005 - 2008 Clinical Cytogenetics and Molecular Genetics, Fellow2001 - 2005 Cancer Cytogenetics; The University of Pittsburgh, Graduate Student Researcher2001 - 2001 Cytogenetics Facility; University of Pittsburgh Cancer Institute and Center for Human Genetics and Integrative Biology, Supervisor1999 - 2001 Allegheny General Hospital, Cytogenetic Technologist

Professional Experience

2008 - Present (Clinical)Pathology, The Ohio State University, Assistant Professor2008 - Present Nationwide Children’s Hospital, Department of Laboratory Medicine, Assistant Director of the Cytogenetics and Molecular Genetics Laboratories2008 - Present The Research Institute at Nationwide Children’s Hospital, Assistant Director of the Children’s Oncology Group Reference Laboratory2005 - 2008 Clinical Cytogenetics and Molecular Genetics, Fellow2001 - 2005 Cancer Cytogenetics; The University of Pittsburgh, Graduate Student Researcher2001 - 2001 Cytogenetics Facility; University of Pittsburgh Cancer Institute and Center for Human Genetics and Integrative Biology, Supervisor1999 - 2001 Allegheny General Hospital, Cytogenetic Technologist

2008 - Present (Clinical)Pathology, The Ohio State University, Assistant Professor2008 - Present Nationwide Children’s Hospital, Department of Laboratory Medicine, Assistant Director of the Cytogenetics and Molecular Genetics Laboratories2008 - Present The Research Institute at Nationwide Children’s Hospital, Assistant Director of the Children’s Oncology Group Reference Laboratory2005 - 2008 Clinical Cytogenetics and Molecular Genetics, Fellow2001 - 2005 Cancer Cytogenetics; The University of Pittsburgh, Graduate Student Researcher2001 - 2001 Cytogenetics Facility; University of Pittsburgh Cancer Institute and Center for Human Genetics and Integrative Biology, Supervisor1999 - 2001 Allegheny General Hospital, Cytogenetic Technologist

2008 - Present (Clinical)Pathology, The Ohio State University, Assistant Professor

Contact Information

Institute for Genomic Medicine

Call us at: (614) 722-5321

Fax us at: (614) 355-6833

                    Laboratory Medicine/ Anatomic Pathology575 Childrens CrossroadColumbus, OH 43215 (map)

Contact Information

Institute for Genomic Medicine

Call us at: (614) 722-5321

Fax us at: (614) 355-6833

                    Laboratory Medicine/ Anatomic Pathology575 Childrens CrossroadColumbus, OH 43215 (map)

Contact Information

Institute for Genomic Medicine

Call us at: (614) 722-5321

Fax us at: (614) 355-6833

                    Laboratory Medicine/ Anatomic Pathology575 Childrens CrossroadColumbus, OH 43215 (map)

Institute for Genomic Medicine

Call us at: (614) 722-5321

Fax us at: (614) 355-6833

                    Laboratory Medicine/ Anatomic Pathology575 Childrens CrossroadColumbus, OH 43215 (map)

Call us at: (614) 722-5321

Fax us at: (614) 355-6833

                    Laboratory Medicine/ Anatomic Pathology575 Childrens CrossroadColumbus, OH 43215 (map)

Call us at: (614) 722-5321

Fax us at: (614) 355-6833

                    Laboratory Medicine/ Anatomic Pathology575 Childrens CrossroadColumbus, OH 43215 (map)

• Call us at:
• (614) 722-5321
• Fax us at:
• (614) 355-6833
• Laboratory Medicine/ Anatomic Pathology575 Childrens CrossroadColumbus, OH 43215 (map)

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