Santiago Partida Sanchez

Contact Information

Call us at: (614)722.4092

Fax us at: (614)722.2818

Email Santiago Partida-Sanchez, PhD

Microbial PathogenesisAbigail Wexner Research Institute700 Children’s DriveColumbus, Ohio 43205 (map)

Learn more about Santiago Partida-Sanchez

Research

Lab(s)

Center for Microbial Pathogenesis

My laboratory is interested in the study of immune cell recruitment induced by infection and/or inflammation. Our research projects are focused on molecular analyses of chemokine receptor-mediated G-protein-linked signaling and calcium influx in neutrophils and DCs. We are conducting experiments to study regulation of calcium influx mediated by CD38-catalyzed metabolites and the ADPR-activated calcium channel TRPM2 in inflammatory cells. We would like to assess whether CD38 inhibiting drugs, CD38-derived antagonists, and/or TRPM2 channel inhibitors, have potential therapeutic use to block undesired chronic inflammatory responses, or harmful T cell responses leading to autoimmunity. This knowledge could allow us to design new strategies for clinical intervention in several immunological disorders, as well as inflammatory and infectious diseases.

View My Publications

Publications

                  Zhang S, Shrestha CL, Robledo-Avila F, Jaganathan D, Wisniewski BL, Brown N, Pham H, Carey K, Amer AO, Hall-Stoodley L, McCoy KS, Bai S, Partida-Sanchez S, Kopp BT. Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor. Eur Respir J. 2022 Oct 20;  

                


                  Merchand-Reyes G, Santhanam R, Robledo-Avila FH, Weigel C, Ruiz-Rosado JD, Mo X, Partida-Sánchez S, Woyach JA, Oakes CC, Tridandapani S, Butchar JP. Disruption of Nurse-like Cell Differentiation as a Therapeutic Strategy for Chronic Lymphocytic Leukemia. J Immunol. 2022 Aug 22;  

                


                  Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis. Proc Natl Acad Sci U S A. 2022 May 24; 119: e2202012119.

                


                  Badr A, Eltobgy M, Krause K, Hamilton K, Estfanous S, Daily KP, Abu Khweek A, Hegazi A, Anne MNK, Carafice C, Robledo-Avila F, Saqr Y, Zhang X, Bonfield TL, Gavrilin MA, Partida-Sanchez S, Seveau S, Cormet-Boyaka E, Amer AO. CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages. Front Cell Infect Microbiol. 2022; 12: 819554.

                


                  Vargas-Roldán SY, Lezana-Fernández JL, Cerna-Cortés JF, Partida-Sánchez S, Santos-Preciado JI, Rosales-Reyes R. Fibrosis quística: patogenia bacteriana y moduladores del CFTR (regulador de conductancia transmembranal de la fibrosis quística). Bol Med Hosp Infant Mex. 2022; 79: 215-221.

                


                  Devaraj A, Novotny LA, Robledo-Avila FH, Buzzo JR, Mashburn-Warren L, Jurcisek JA, Tjokro NO, Partida-Sanchez S, Bakaletz LO, Goodman SD. The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation. J Clin Invest. 2021 Aug 16; 131: 

                


                  Yang C, Ruiz-Rosado JD, Robledo-Avila FH, Li Z, Jennings RN, Partida-Sanchez S, Montgomery CP. Antibody-Mediated Protection against Staphylococcus aureus Dermonecrosis: Synergy of Toxin Neutralization and Neutrophil Recruitment. J Invest Dermatol. 2021 Apr; 141: 810-820.e8.

                


                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

                


                  Partida-Sanchez S, Desai BN, Schwab A, Zierler S. Editorial: TRP Channels in Inflammation and Immunity. Front Immunol. 2021; 12: 684172.

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Partida-Sanchez S, Brockman KL. A Bacterial Epigenetic Switch in Non-typeable Haemophilus influenzae Modifies Host Immune Response During Otitis Media. Front Cell Infect Microbiol. 2020; 10: 512743.

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Partida-Sánchez S. The TRPM2 Ion Channel Regulates Inflammatory Functions of Neutrophils During Listeria monocytogenes Infection. Front Immunol. 2020; 11: 97.

                


                  Merchand-Reyes G, Robledo-Avila FH, Buteyn NJ, Gautam S, Santhanam R, Fatehchand K, Mo X, Partida-Sanchez S, Butchar JP, Tridandapani S. CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc?R-Mediated Signaling in Monocytes. J Immunol. 2019 Dec 15; 203: 3216-3224.

                


                  Sharma N, Dev R, Ruiz-Rosado JD, Partida-Sanchez S, Guerau-de-Arellano M, Dhakal P, Kuivaniemi H, Hans CP. Pharmacological inhibition of Notch signaling regresses pre-established abdominal aortic aneurysm. Sci Rep. 2019 Sep 17; 9: 13458.

                


                  Kopp BT, Fitch J, Jaramillo L, Shrestha CL, Robledo-Avila F, Zhang S, Palacios S, Woodley F, Hayes D Jr, Partida-Sanchez S, Ramilo O, White P, Mejias A. Whole-blood transcriptomic responses to lumacaftor/ivacaftor therapy in cystic fibrosis. J Cyst Fibros. 2019 Aug 29;  

                


                  Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.

                


                  Martínez-Saucedo D, Ruíz-Rosado JD, Terrazas C, Callejas BE, Satoskar AR, Partida-Sánchez S, Terrazas LI. Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages. J Immunol Res. 2019; 2019: 2946713.

                


                  Caution K, Young N, Robledo-Avila F, Krause K, Abu Khweek A, Hamilton K, Badr A, Vaidya A, Daily K, Gosu H, Anne MNK, Eltobgy M, Dakhlallah D, Argwal S, Estfanous S, Zhang X, Partida-Sanchez S, Gavrilin MA, Jarjour WN, Amer AO. Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation. Front Immunol. 2019; 10: 2519.

                


                  Assani K, Shrestha CL, Rinehardt H, Zhang S, Robledo-Avila F, Wellmerling J, Partida-Sanchez S, Cormet-Boyaka E, Reynolds SD, Schlesinger LS, Kopp BT. AR-13 reduces antibiotic-resistant bacterial burden in cystic fibrosis phagocytes and improves cystic fibrosis transmembrane conductance regulator function. J Cyst Fibros. 2018 Oct 23;  

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Kopp BT, Amer AO, McCoy K, Bakaletz LO, Partida-Sanchez S. Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses. J Immunol. 2018 Oct 1; 201: 2016-2027.

                


                  Krause K, Kopp BT, Tazi MF, Caution K, Hamilton K, Badr A, Shrestha C, Tumin D, Hayes D Jr, Robledo-Avila F, Hall-Stoodley L, Klamer BG, Zhang X, Partida-Sanchez S, Parinandi NL, Kirkby SE, Dakhlallah D, McCoy KS, Cormet-Boyaka E, Amer AO. The expression of Mirc1/Mir17-92 cluster in sputum samples correlates with pulmonary exacerbations in cystic fibrosis patients. J Cyst Fibros. 2018 Jul; 17: 454-461.

                


                  Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15;  fj201800458.

                


                  Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, Delgado-Martin C, Partida-Sanchez S, Rodriguez-Fernandez JL, Nagy L, Tontonoz P, Castrillo A. LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis. Mol Cell Biol. 2018 Mar 5;  

                


                  Almasi S, Kennedy BE, El-Aghil M, Sterea AM, Gujar S, Partida-Sánchez S, El Hiani Y. TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway. J Biol Chem. 2018 Mar 9; 293: 3637-3650.

                


                  Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO. The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils. Sci Rep. 2017 Jun 9; 7: 3161.

                


                  Assani K, Shrestha CL, Robledo-Avila F, Rajaram MV, Partida-Sanchez S, Schlesinger LS, Kopp BT. Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by Burkholderia cenocepacia. J Immunol. 2017 Mar 1; 198: 1985-1994.

                


                  Beceiro S, Radin JN, Chatuvedi R, Piazuelo MB, Horvarth DJ, Cortado H, Gu Y, Dixon B, Gu C, Lange I, Koomoa DL, Wilson KT, Algood HM, Partida-Sánchez S. TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection. Mucosal Immunol. 2017 Mar; 10: 493-507.

                


                  Terrazas C, de Dios Ruiz-Rosado J, Amici SA, Jablonski KA, Martinez-Saucedo D, Webb LM, Cortado H, Robledo-Avila F, Oghumu S, Satoskar AR, Rodriguez-Sosa M, Terrazas LI, Guerau-de-Arellano M, Partida-Sánchez S. Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis. Sci Rep. 2017 Jan 17; 7: 40814.

View More Publications

Biography

        Santiago Partida-Sanchez, PhD is a Principal Investigator at The Research Institute at Nationwide Children’s Hospital.  He is an Associate Professor of Pediatrics at the Ohio State University College of Medicine.  Dr. Partida-Sanchez’s NIH funded research program focuses on identifying mechanisms of activation of calcium cellular signals via TRP type ion channels. His team's goal is to elucidate how those pathways impact on the functions of innate immune cells, such as macrophages and dendritic cells.  Dr. Partida-Sanchez's research will provide insights into how inflammatory cells are recruited during infection or inflammation, and will help to develop cellular migration inhibitors with therapeutic potential.

Academic and Clinical Areas

Center for Microbial Pathogenesis

Principal Investigator

Primary Department

Microbial Pathogenesis

Professional Experience

2011 - Present The Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Public Health, Associate Professor of Pediatrics2004 - Present Integrated Biomedical Science Graduate Program and Molecular, Cellular and Development Biology Program, The Ohio State University, College of Medicine and Public Health, Graduate Faculty Member2004 - 2011 The Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Public Health, Assistant Professor of Pediatrics2003 - 2004 The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund., Research Scientist1998 - 2003 The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund., Post-Doctoral Fellow

Contact Information

Microbial Pathogenesis

Call us at: (614)722.4092

Fax us at: (614)722.2818

Email Santiago Partida Sanchez

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Contact Information

Call us at: (614)722.4092

Fax us at: (614)722.2818

Email Santiago Partida-Sanchez, PhD

Microbial PathogenesisAbigail Wexner Research Institute700 Children’s DriveColumbus, Ohio 43205 (map)

Learn more about Santiago Partida-Sanchez

Research

Lab(s)

Center for Microbial Pathogenesis

My laboratory is interested in the study of immune cell recruitment induced by infection and/or inflammation. Our research projects are focused on molecular analyses of chemokine receptor-mediated G-protein-linked signaling and calcium influx in neutrophils and DCs. We are conducting experiments to study regulation of calcium influx mediated by CD38-catalyzed metabolites and the ADPR-activated calcium channel TRPM2 in inflammatory cells. We would like to assess whether CD38 inhibiting drugs, CD38-derived antagonists, and/or TRPM2 channel inhibitors, have potential therapeutic use to block undesired chronic inflammatory responses, or harmful T cell responses leading to autoimmunity. This knowledge could allow us to design new strategies for clinical intervention in several immunological disorders, as well as inflammatory and infectious diseases.

View My Publications

Publications

                  Zhang S, Shrestha CL, Robledo-Avila F, Jaganathan D, Wisniewski BL, Brown N, Pham H, Carey K, Amer AO, Hall-Stoodley L, McCoy KS, Bai S, Partida-Sanchez S, Kopp BT. Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor. Eur Respir J. 2022 Oct 20;  

                


                  Merchand-Reyes G, Santhanam R, Robledo-Avila FH, Weigel C, Ruiz-Rosado JD, Mo X, Partida-Sánchez S, Woyach JA, Oakes CC, Tridandapani S, Butchar JP. Disruption of Nurse-like Cell Differentiation as a Therapeutic Strategy for Chronic Lymphocytic Leukemia. J Immunol. 2022 Aug 22;  

                


                  Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis. Proc Natl Acad Sci U S A. 2022 May 24; 119: e2202012119.

                


                  Badr A, Eltobgy M, Krause K, Hamilton K, Estfanous S, Daily KP, Abu Khweek A, Hegazi A, Anne MNK, Carafice C, Robledo-Avila F, Saqr Y, Zhang X, Bonfield TL, Gavrilin MA, Partida-Sanchez S, Seveau S, Cormet-Boyaka E, Amer AO. CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages. Front Cell Infect Microbiol. 2022; 12: 819554.

                


                  Vargas-Roldán SY, Lezana-Fernández JL, Cerna-Cortés JF, Partida-Sánchez S, Santos-Preciado JI, Rosales-Reyes R. Fibrosis quística: patogenia bacteriana y moduladores del CFTR (regulador de conductancia transmembranal de la fibrosis quística). Bol Med Hosp Infant Mex. 2022; 79: 215-221.

                


                  Devaraj A, Novotny LA, Robledo-Avila FH, Buzzo JR, Mashburn-Warren L, Jurcisek JA, Tjokro NO, Partida-Sanchez S, Bakaletz LO, Goodman SD. The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation. J Clin Invest. 2021 Aug 16; 131: 

                


                  Yang C, Ruiz-Rosado JD, Robledo-Avila FH, Li Z, Jennings RN, Partida-Sanchez S, Montgomery CP. Antibody-Mediated Protection against Staphylococcus aureus Dermonecrosis: Synergy of Toxin Neutralization and Neutrophil Recruitment. J Invest Dermatol. 2021 Apr; 141: 810-820.e8.

                


                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

                


                  Partida-Sanchez S, Desai BN, Schwab A, Zierler S. Editorial: TRP Channels in Inflammation and Immunity. Front Immunol. 2021; 12: 684172.

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Partida-Sanchez S, Brockman KL. A Bacterial Epigenetic Switch in Non-typeable Haemophilus influenzae Modifies Host Immune Response During Otitis Media. Front Cell Infect Microbiol. 2020; 10: 512743.

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Partida-Sánchez S. The TRPM2 Ion Channel Regulates Inflammatory Functions of Neutrophils During Listeria monocytogenes Infection. Front Immunol. 2020; 11: 97.

                


                  Merchand-Reyes G, Robledo-Avila FH, Buteyn NJ, Gautam S, Santhanam R, Fatehchand K, Mo X, Partida-Sanchez S, Butchar JP, Tridandapani S. CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc?R-Mediated Signaling in Monocytes. J Immunol. 2019 Dec 15; 203: 3216-3224.

                


                  Sharma N, Dev R, Ruiz-Rosado JD, Partida-Sanchez S, Guerau-de-Arellano M, Dhakal P, Kuivaniemi H, Hans CP. Pharmacological inhibition of Notch signaling regresses pre-established abdominal aortic aneurysm. Sci Rep. 2019 Sep 17; 9: 13458.

                


                  Kopp BT, Fitch J, Jaramillo L, Shrestha CL, Robledo-Avila F, Zhang S, Palacios S, Woodley F, Hayes D Jr, Partida-Sanchez S, Ramilo O, White P, Mejias A. Whole-blood transcriptomic responses to lumacaftor/ivacaftor therapy in cystic fibrosis. J Cyst Fibros. 2019 Aug 29;  

                


                  Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.

                


                  Martínez-Saucedo D, Ruíz-Rosado JD, Terrazas C, Callejas BE, Satoskar AR, Partida-Sánchez S, Terrazas LI. Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages. J Immunol Res. 2019; 2019: 2946713.

                


                  Caution K, Young N, Robledo-Avila F, Krause K, Abu Khweek A, Hamilton K, Badr A, Vaidya A, Daily K, Gosu H, Anne MNK, Eltobgy M, Dakhlallah D, Argwal S, Estfanous S, Zhang X, Partida-Sanchez S, Gavrilin MA, Jarjour WN, Amer AO. Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation. Front Immunol. 2019; 10: 2519.

                


                  Assani K, Shrestha CL, Rinehardt H, Zhang S, Robledo-Avila F, Wellmerling J, Partida-Sanchez S, Cormet-Boyaka E, Reynolds SD, Schlesinger LS, Kopp BT. AR-13 reduces antibiotic-resistant bacterial burden in cystic fibrosis phagocytes and improves cystic fibrosis transmembrane conductance regulator function. J Cyst Fibros. 2018 Oct 23;  

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Kopp BT, Amer AO, McCoy K, Bakaletz LO, Partida-Sanchez S. Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses. J Immunol. 2018 Oct 1; 201: 2016-2027.

                


                  Krause K, Kopp BT, Tazi MF, Caution K, Hamilton K, Badr A, Shrestha C, Tumin D, Hayes D Jr, Robledo-Avila F, Hall-Stoodley L, Klamer BG, Zhang X, Partida-Sanchez S, Parinandi NL, Kirkby SE, Dakhlallah D, McCoy KS, Cormet-Boyaka E, Amer AO. The expression of Mirc1/Mir17-92 cluster in sputum samples correlates with pulmonary exacerbations in cystic fibrosis patients. J Cyst Fibros. 2018 Jul; 17: 454-461.

                


                  Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15;  fj201800458.

                


                  Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, Delgado-Martin C, Partida-Sanchez S, Rodriguez-Fernandez JL, Nagy L, Tontonoz P, Castrillo A. LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis. Mol Cell Biol. 2018 Mar 5;  

                


                  Almasi S, Kennedy BE, El-Aghil M, Sterea AM, Gujar S, Partida-Sánchez S, El Hiani Y. TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway. J Biol Chem. 2018 Mar 9; 293: 3637-3650.

                


                  Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO. The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils. Sci Rep. 2017 Jun 9; 7: 3161.

                


                  Assani K, Shrestha CL, Robledo-Avila F, Rajaram MV, Partida-Sanchez S, Schlesinger LS, Kopp BT. Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by Burkholderia cenocepacia. J Immunol. 2017 Mar 1; 198: 1985-1994.

                


                  Beceiro S, Radin JN, Chatuvedi R, Piazuelo MB, Horvarth DJ, Cortado H, Gu Y, Dixon B, Gu C, Lange I, Koomoa DL, Wilson KT, Algood HM, Partida-Sánchez S. TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection. Mucosal Immunol. 2017 Mar; 10: 493-507.

                


                  Terrazas C, de Dios Ruiz-Rosado J, Amici SA, Jablonski KA, Martinez-Saucedo D, Webb LM, Cortado H, Robledo-Avila F, Oghumu S, Satoskar AR, Rodriguez-Sosa M, Terrazas LI, Guerau-de-Arellano M, Partida-Sánchez S. Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis. Sci Rep. 2017 Jan 17; 7: 40814.

View More Publications

Biography

        Santiago Partida-Sanchez, PhD is a Principal Investigator at The Research Institute at Nationwide Children’s Hospital.  He is an Associate Professor of Pediatrics at the Ohio State University College of Medicine.  Dr. Partida-Sanchez’s NIH funded research program focuses on identifying mechanisms of activation of calcium cellular signals via TRP type ion channels. His team's goal is to elucidate how those pathways impact on the functions of innate immune cells, such as macrophages and dendritic cells.  Dr. Partida-Sanchez's research will provide insights into how inflammatory cells are recruited during infection or inflammation, and will help to develop cellular migration inhibitors with therapeutic potential.

Academic and Clinical Areas

Center for Microbial Pathogenesis

Principal Investigator

Primary Department

Microbial Pathogenesis

Professional Experience

2011 - Present The Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Public Health, Associate Professor of Pediatrics2004 - Present Integrated Biomedical Science Graduate Program and Molecular, Cellular and Development Biology Program, The Ohio State University, College of Medicine and Public Health, Graduate Faculty Member2004 - 2011 The Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Public Health, Assistant Professor of Pediatrics2003 - 2004 The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund., Research Scientist1998 - 2003 The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund., Post-Doctoral Fellow

Contact Information

Microbial Pathogenesis

Call us at: (614)722.4092

Fax us at: (614)722.2818

Email Santiago Partida Sanchez

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Contact Information

Call us at: (614)722.4092

Fax us at: (614)722.2818

Email Santiago Partida-Sanchez, PhD

Microbial PathogenesisAbigail Wexner Research Institute700 Children’s DriveColumbus, Ohio 43205 (map)

Learn more about Santiago Partida-Sanchez

Contact Information

• Call us at:
• (614)722.4092
• Fax us at:
• (614)722.2818
• Email Santiago Partida-Sanchez, PhD
• Microbial PathogenesisAbigail Wexner Research Institute700 Children’s DriveColumbus, Ohio 43205 (map)

Learn more about Santiago Partida-Sanchez

Research

Lab(s)

Center for Microbial Pathogenesis

My laboratory is interested in the study of immune cell recruitment induced by infection and/or inflammation. Our research projects are focused on molecular analyses of chemokine receptor-mediated G-protein-linked signaling and calcium influx in neutrophils and DCs. We are conducting experiments to study regulation of calcium influx mediated by CD38-catalyzed metabolites and the ADPR-activated calcium channel TRPM2 in inflammatory cells. We would like to assess whether CD38 inhibiting drugs, CD38-derived antagonists, and/or TRPM2 channel inhibitors, have potential therapeutic use to block undesired chronic inflammatory responses, or harmful T cell responses leading to autoimmunity. This knowledge could allow us to design new strategies for clinical intervention in several immunological disorders, as well as inflammatory and infectious diseases.

View My Publications

Publications

                  Zhang S, Shrestha CL, Robledo-Avila F, Jaganathan D, Wisniewski BL, Brown N, Pham H, Carey K, Amer AO, Hall-Stoodley L, McCoy KS, Bai S, Partida-Sanchez S, Kopp BT. Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor. Eur Respir J. 2022 Oct 20;  

                


                  Merchand-Reyes G, Santhanam R, Robledo-Avila FH, Weigel C, Ruiz-Rosado JD, Mo X, Partida-Sánchez S, Woyach JA, Oakes CC, Tridandapani S, Butchar JP. Disruption of Nurse-like Cell Differentiation as a Therapeutic Strategy for Chronic Lymphocytic Leukemia. J Immunol. 2022 Aug 22;  

                


                  Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis. Proc Natl Acad Sci U S A. 2022 May 24; 119: e2202012119.

                


                  Badr A, Eltobgy M, Krause K, Hamilton K, Estfanous S, Daily KP, Abu Khweek A, Hegazi A, Anne MNK, Carafice C, Robledo-Avila F, Saqr Y, Zhang X, Bonfield TL, Gavrilin MA, Partida-Sanchez S, Seveau S, Cormet-Boyaka E, Amer AO. CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages. Front Cell Infect Microbiol. 2022; 12: 819554.

                


                  Vargas-Roldán SY, Lezana-Fernández JL, Cerna-Cortés JF, Partida-Sánchez S, Santos-Preciado JI, Rosales-Reyes R. Fibrosis quística: patogenia bacteriana y moduladores del CFTR (regulador de conductancia transmembranal de la fibrosis quística). Bol Med Hosp Infant Mex. 2022; 79: 215-221.

                


                  Devaraj A, Novotny LA, Robledo-Avila FH, Buzzo JR, Mashburn-Warren L, Jurcisek JA, Tjokro NO, Partida-Sanchez S, Bakaletz LO, Goodman SD. The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation. J Clin Invest. 2021 Aug 16; 131: 

                


                  Yang C, Ruiz-Rosado JD, Robledo-Avila FH, Li Z, Jennings RN, Partida-Sanchez S, Montgomery CP. Antibody-Mediated Protection against Staphylococcus aureus Dermonecrosis: Synergy of Toxin Neutralization and Neutrophil Recruitment. J Invest Dermatol. 2021 Apr; 141: 810-820.e8.

                


                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

                


                  Partida-Sanchez S, Desai BN, Schwab A, Zierler S. Editorial: TRP Channels in Inflammation and Immunity. Front Immunol. 2021; 12: 684172.

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Partida-Sanchez S, Brockman KL. A Bacterial Epigenetic Switch in Non-typeable Haemophilus influenzae Modifies Host Immune Response During Otitis Media. Front Cell Infect Microbiol. 2020; 10: 512743.

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Partida-Sánchez S. The TRPM2 Ion Channel Regulates Inflammatory Functions of Neutrophils During Listeria monocytogenes Infection. Front Immunol. 2020; 11: 97.

                


                  Merchand-Reyes G, Robledo-Avila FH, Buteyn NJ, Gautam S, Santhanam R, Fatehchand K, Mo X, Partida-Sanchez S, Butchar JP, Tridandapani S. CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc?R-Mediated Signaling in Monocytes. J Immunol. 2019 Dec 15; 203: 3216-3224.

                


                  Sharma N, Dev R, Ruiz-Rosado JD, Partida-Sanchez S, Guerau-de-Arellano M, Dhakal P, Kuivaniemi H, Hans CP. Pharmacological inhibition of Notch signaling regresses pre-established abdominal aortic aneurysm. Sci Rep. 2019 Sep 17; 9: 13458.

                


                  Kopp BT, Fitch J, Jaramillo L, Shrestha CL, Robledo-Avila F, Zhang S, Palacios S, Woodley F, Hayes D Jr, Partida-Sanchez S, Ramilo O, White P, Mejias A. Whole-blood transcriptomic responses to lumacaftor/ivacaftor therapy in cystic fibrosis. J Cyst Fibros. 2019 Aug 29;  

                


                  Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.

                


                  Martínez-Saucedo D, Ruíz-Rosado JD, Terrazas C, Callejas BE, Satoskar AR, Partida-Sánchez S, Terrazas LI. Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages. J Immunol Res. 2019; 2019: 2946713.

                


                  Caution K, Young N, Robledo-Avila F, Krause K, Abu Khweek A, Hamilton K, Badr A, Vaidya A, Daily K, Gosu H, Anne MNK, Eltobgy M, Dakhlallah D, Argwal S, Estfanous S, Zhang X, Partida-Sanchez S, Gavrilin MA, Jarjour WN, Amer AO. Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation. Front Immunol. 2019; 10: 2519.

                


                  Assani K, Shrestha CL, Rinehardt H, Zhang S, Robledo-Avila F, Wellmerling J, Partida-Sanchez S, Cormet-Boyaka E, Reynolds SD, Schlesinger LS, Kopp BT. AR-13 reduces antibiotic-resistant bacterial burden in cystic fibrosis phagocytes and improves cystic fibrosis transmembrane conductance regulator function. J Cyst Fibros. 2018 Oct 23;  

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Kopp BT, Amer AO, McCoy K, Bakaletz LO, Partida-Sanchez S. Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses. J Immunol. 2018 Oct 1; 201: 2016-2027.

                


                  Krause K, Kopp BT, Tazi MF, Caution K, Hamilton K, Badr A, Shrestha C, Tumin D, Hayes D Jr, Robledo-Avila F, Hall-Stoodley L, Klamer BG, Zhang X, Partida-Sanchez S, Parinandi NL, Kirkby SE, Dakhlallah D, McCoy KS, Cormet-Boyaka E, Amer AO. The expression of Mirc1/Mir17-92 cluster in sputum samples correlates with pulmonary exacerbations in cystic fibrosis patients. J Cyst Fibros. 2018 Jul; 17: 454-461.

                


                  Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15;  fj201800458.

                


                  Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, Delgado-Martin C, Partida-Sanchez S, Rodriguez-Fernandez JL, Nagy L, Tontonoz P, Castrillo A. LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis. Mol Cell Biol. 2018 Mar 5;  

                


                  Almasi S, Kennedy BE, El-Aghil M, Sterea AM, Gujar S, Partida-Sánchez S, El Hiani Y. TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway. J Biol Chem. 2018 Mar 9; 293: 3637-3650.

                


                  Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO. The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils. Sci Rep. 2017 Jun 9; 7: 3161.

                


                  Assani K, Shrestha CL, Robledo-Avila F, Rajaram MV, Partida-Sanchez S, Schlesinger LS, Kopp BT. Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by Burkholderia cenocepacia. J Immunol. 2017 Mar 1; 198: 1985-1994.

                


                  Beceiro S, Radin JN, Chatuvedi R, Piazuelo MB, Horvarth DJ, Cortado H, Gu Y, Dixon B, Gu C, Lange I, Koomoa DL, Wilson KT, Algood HM, Partida-Sánchez S. TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection. Mucosal Immunol. 2017 Mar; 10: 493-507.

                


                  Terrazas C, de Dios Ruiz-Rosado J, Amici SA, Jablonski KA, Martinez-Saucedo D, Webb LM, Cortado H, Robledo-Avila F, Oghumu S, Satoskar AR, Rodriguez-Sosa M, Terrazas LI, Guerau-de-Arellano M, Partida-Sánchez S. Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis. Sci Rep. 2017 Jan 17; 7: 40814.

View More Publications

Research

Lab(s)

Center for Microbial Pathogenesis

My laboratory is interested in the study of immune cell recruitment induced by infection and/or inflammation. Our research projects are focused on molecular analyses of chemokine receptor-mediated G-protein-linked signaling and calcium influx in neutrophils and DCs. We are conducting experiments to study regulation of calcium influx mediated by CD38-catalyzed metabolites and the ADPR-activated calcium channel TRPM2 in inflammatory cells. We would like to assess whether CD38 inhibiting drugs, CD38-derived antagonists, and/or TRPM2 channel inhibitors, have potential therapeutic use to block undesired chronic inflammatory responses, or harmful T cell responses leading to autoimmunity. This knowledge could allow us to design new strategies for clinical intervention in several immunological disorders, as well as inflammatory and infectious diseases.

View My Publications

Publications

                  Zhang S, Shrestha CL, Robledo-Avila F, Jaganathan D, Wisniewski BL, Brown N, Pham H, Carey K, Amer AO, Hall-Stoodley L, McCoy KS, Bai S, Partida-Sanchez S, Kopp BT. Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor. Eur Respir J. 2022 Oct 20;  

                


                  Merchand-Reyes G, Santhanam R, Robledo-Avila FH, Weigel C, Ruiz-Rosado JD, Mo X, Partida-Sánchez S, Woyach JA, Oakes CC, Tridandapani S, Butchar JP. Disruption of Nurse-like Cell Differentiation as a Therapeutic Strategy for Chronic Lymphocytic Leukemia. J Immunol. 2022 Aug 22;  

                


                  Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis. Proc Natl Acad Sci U S A. 2022 May 24; 119: e2202012119.

                


                  Badr A, Eltobgy M, Krause K, Hamilton K, Estfanous S, Daily KP, Abu Khweek A, Hegazi A, Anne MNK, Carafice C, Robledo-Avila F, Saqr Y, Zhang X, Bonfield TL, Gavrilin MA, Partida-Sanchez S, Seveau S, Cormet-Boyaka E, Amer AO. CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages. Front Cell Infect Microbiol. 2022; 12: 819554.

                


                  Vargas-Roldán SY, Lezana-Fernández JL, Cerna-Cortés JF, Partida-Sánchez S, Santos-Preciado JI, Rosales-Reyes R. Fibrosis quística: patogenia bacteriana y moduladores del CFTR (regulador de conductancia transmembranal de la fibrosis quística). Bol Med Hosp Infant Mex. 2022; 79: 215-221.

                


                  Devaraj A, Novotny LA, Robledo-Avila FH, Buzzo JR, Mashburn-Warren L, Jurcisek JA, Tjokro NO, Partida-Sanchez S, Bakaletz LO, Goodman SD. The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation. J Clin Invest. 2021 Aug 16; 131: 

                


                  Yang C, Ruiz-Rosado JD, Robledo-Avila FH, Li Z, Jennings RN, Partida-Sanchez S, Montgomery CP. Antibody-Mediated Protection against Staphylococcus aureus Dermonecrosis: Synergy of Toxin Neutralization and Neutrophil Recruitment. J Invest Dermatol. 2021 Apr; 141: 810-820.e8.

                


                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

                


                  Partida-Sanchez S, Desai BN, Schwab A, Zierler S. Editorial: TRP Channels in Inflammation and Immunity. Front Immunol. 2021; 12: 684172.

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Partida-Sanchez S, Brockman KL. A Bacterial Epigenetic Switch in Non-typeable Haemophilus influenzae Modifies Host Immune Response During Otitis Media. Front Cell Infect Microbiol. 2020; 10: 512743.

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Partida-Sánchez S. The TRPM2 Ion Channel Regulates Inflammatory Functions of Neutrophils During Listeria monocytogenes Infection. Front Immunol. 2020; 11: 97.

                


                  Merchand-Reyes G, Robledo-Avila FH, Buteyn NJ, Gautam S, Santhanam R, Fatehchand K, Mo X, Partida-Sanchez S, Butchar JP, Tridandapani S. CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc?R-Mediated Signaling in Monocytes. J Immunol. 2019 Dec 15; 203: 3216-3224.

                


                  Sharma N, Dev R, Ruiz-Rosado JD, Partida-Sanchez S, Guerau-de-Arellano M, Dhakal P, Kuivaniemi H, Hans CP. Pharmacological inhibition of Notch signaling regresses pre-established abdominal aortic aneurysm. Sci Rep. 2019 Sep 17; 9: 13458.

                


                  Kopp BT, Fitch J, Jaramillo L, Shrestha CL, Robledo-Avila F, Zhang S, Palacios S, Woodley F, Hayes D Jr, Partida-Sanchez S, Ramilo O, White P, Mejias A. Whole-blood transcriptomic responses to lumacaftor/ivacaftor therapy in cystic fibrosis. J Cyst Fibros. 2019 Aug 29;  

                


                  Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.

                


                  Martínez-Saucedo D, Ruíz-Rosado JD, Terrazas C, Callejas BE, Satoskar AR, Partida-Sánchez S, Terrazas LI. Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages. J Immunol Res. 2019; 2019: 2946713.

                


                  Caution K, Young N, Robledo-Avila F, Krause K, Abu Khweek A, Hamilton K, Badr A, Vaidya A, Daily K, Gosu H, Anne MNK, Eltobgy M, Dakhlallah D, Argwal S, Estfanous S, Zhang X, Partida-Sanchez S, Gavrilin MA, Jarjour WN, Amer AO. Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation. Front Immunol. 2019; 10: 2519.

                


                  Assani K, Shrestha CL, Rinehardt H, Zhang S, Robledo-Avila F, Wellmerling J, Partida-Sanchez S, Cormet-Boyaka E, Reynolds SD, Schlesinger LS, Kopp BT. AR-13 reduces antibiotic-resistant bacterial burden in cystic fibrosis phagocytes and improves cystic fibrosis transmembrane conductance regulator function. J Cyst Fibros. 2018 Oct 23;  

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Kopp BT, Amer AO, McCoy K, Bakaletz LO, Partida-Sanchez S. Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses. J Immunol. 2018 Oct 1; 201: 2016-2027.

                


                  Krause K, Kopp BT, Tazi MF, Caution K, Hamilton K, Badr A, Shrestha C, Tumin D, Hayes D Jr, Robledo-Avila F, Hall-Stoodley L, Klamer BG, Zhang X, Partida-Sanchez S, Parinandi NL, Kirkby SE, Dakhlallah D, McCoy KS, Cormet-Boyaka E, Amer AO. The expression of Mirc1/Mir17-92 cluster in sputum samples correlates with pulmonary exacerbations in cystic fibrosis patients. J Cyst Fibros. 2018 Jul; 17: 454-461.

                


                  Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15;  fj201800458.

                


                  Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, Delgado-Martin C, Partida-Sanchez S, Rodriguez-Fernandez JL, Nagy L, Tontonoz P, Castrillo A. LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis. Mol Cell Biol. 2018 Mar 5;  

                


                  Almasi S, Kennedy BE, El-Aghil M, Sterea AM, Gujar S, Partida-Sánchez S, El Hiani Y. TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway. J Biol Chem. 2018 Mar 9; 293: 3637-3650.

                


                  Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO. The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils. Sci Rep. 2017 Jun 9; 7: 3161.

                


                  Assani K, Shrestha CL, Robledo-Avila F, Rajaram MV, Partida-Sanchez S, Schlesinger LS, Kopp BT. Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by Burkholderia cenocepacia. J Immunol. 2017 Mar 1; 198: 1985-1994.

                


                  Beceiro S, Radin JN, Chatuvedi R, Piazuelo MB, Horvarth DJ, Cortado H, Gu Y, Dixon B, Gu C, Lange I, Koomoa DL, Wilson KT, Algood HM, Partida-Sánchez S. TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection. Mucosal Immunol. 2017 Mar; 10: 493-507.

                


                  Terrazas C, de Dios Ruiz-Rosado J, Amici SA, Jablonski KA, Martinez-Saucedo D, Webb LM, Cortado H, Robledo-Avila F, Oghumu S, Satoskar AR, Rodriguez-Sosa M, Terrazas LI, Guerau-de-Arellano M, Partida-Sánchez S. Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis. Sci Rep. 2017 Jan 17; 7: 40814.

View More Publications

Research

Lab(s)

Center for Microbial Pathogenesis

My laboratory is interested in the study of immune cell recruitment induced by infection and/or inflammation. Our research projects are focused on molecular analyses of chemokine receptor-mediated G-protein-linked signaling and calcium influx in neutrophils and DCs. We are conducting experiments to study regulation of calcium influx mediated by CD38-catalyzed metabolites and the ADPR-activated calcium channel TRPM2 in inflammatory cells. We would like to assess whether CD38 inhibiting drugs, CD38-derived antagonists, and/or TRPM2 channel inhibitors, have potential therapeutic use to block undesired chronic inflammatory responses, or harmful T cell responses leading to autoimmunity. This knowledge could allow us to design new strategies for clinical intervention in several immunological disorders, as well as inflammatory and infectious diseases.

View My Publications

Publications

                  Zhang S, Shrestha CL, Robledo-Avila F, Jaganathan D, Wisniewski BL, Brown N, Pham H, Carey K, Amer AO, Hall-Stoodley L, McCoy KS, Bai S, Partida-Sanchez S, Kopp BT. Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor. Eur Respir J. 2022 Oct 20;  

                


                  Merchand-Reyes G, Santhanam R, Robledo-Avila FH, Weigel C, Ruiz-Rosado JD, Mo X, Partida-Sánchez S, Woyach JA, Oakes CC, Tridandapani S, Butchar JP. Disruption of Nurse-like Cell Differentiation as a Therapeutic Strategy for Chronic Lymphocytic Leukemia. J Immunol. 2022 Aug 22;  

                


                  Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis. Proc Natl Acad Sci U S A. 2022 May 24; 119: e2202012119.

                


                  Badr A, Eltobgy M, Krause K, Hamilton K, Estfanous S, Daily KP, Abu Khweek A, Hegazi A, Anne MNK, Carafice C, Robledo-Avila F, Saqr Y, Zhang X, Bonfield TL, Gavrilin MA, Partida-Sanchez S, Seveau S, Cormet-Boyaka E, Amer AO. CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages. Front Cell Infect Microbiol. 2022; 12: 819554.

                


                  Vargas-Roldán SY, Lezana-Fernández JL, Cerna-Cortés JF, Partida-Sánchez S, Santos-Preciado JI, Rosales-Reyes R. Fibrosis quística: patogenia bacteriana y moduladores del CFTR (regulador de conductancia transmembranal de la fibrosis quística). Bol Med Hosp Infant Mex. 2022; 79: 215-221.

                


                  Devaraj A, Novotny LA, Robledo-Avila FH, Buzzo JR, Mashburn-Warren L, Jurcisek JA, Tjokro NO, Partida-Sanchez S, Bakaletz LO, Goodman SD. The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation. J Clin Invest. 2021 Aug 16; 131: 

                


                  Yang C, Ruiz-Rosado JD, Robledo-Avila FH, Li Z, Jennings RN, Partida-Sanchez S, Montgomery CP. Antibody-Mediated Protection against Staphylococcus aureus Dermonecrosis: Synergy of Toxin Neutralization and Neutrophil Recruitment. J Invest Dermatol. 2021 Apr; 141: 810-820.e8.

                


                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

                


                  Partida-Sanchez S, Desai BN, Schwab A, Zierler S. Editorial: TRP Channels in Inflammation and Immunity. Front Immunol. 2021; 12: 684172.

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Partida-Sanchez S, Brockman KL. A Bacterial Epigenetic Switch in Non-typeable Haemophilus influenzae Modifies Host Immune Response During Otitis Media. Front Cell Infect Microbiol. 2020; 10: 512743.

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Partida-Sánchez S. The TRPM2 Ion Channel Regulates Inflammatory Functions of Neutrophils During Listeria monocytogenes Infection. Front Immunol. 2020; 11: 97.

                


                  Merchand-Reyes G, Robledo-Avila FH, Buteyn NJ, Gautam S, Santhanam R, Fatehchand K, Mo X, Partida-Sanchez S, Butchar JP, Tridandapani S. CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc?R-Mediated Signaling in Monocytes. J Immunol. 2019 Dec 15; 203: 3216-3224.

                


                  Sharma N, Dev R, Ruiz-Rosado JD, Partida-Sanchez S, Guerau-de-Arellano M, Dhakal P, Kuivaniemi H, Hans CP. Pharmacological inhibition of Notch signaling regresses pre-established abdominal aortic aneurysm. Sci Rep. 2019 Sep 17; 9: 13458.

                


                  Kopp BT, Fitch J, Jaramillo L, Shrestha CL, Robledo-Avila F, Zhang S, Palacios S, Woodley F, Hayes D Jr, Partida-Sanchez S, Ramilo O, White P, Mejias A. Whole-blood transcriptomic responses to lumacaftor/ivacaftor therapy in cystic fibrosis. J Cyst Fibros. 2019 Aug 29;  

                


                  Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.

                


                  Martínez-Saucedo D, Ruíz-Rosado JD, Terrazas C, Callejas BE, Satoskar AR, Partida-Sánchez S, Terrazas LI. Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages. J Immunol Res. 2019; 2019: 2946713.

                


                  Caution K, Young N, Robledo-Avila F, Krause K, Abu Khweek A, Hamilton K, Badr A, Vaidya A, Daily K, Gosu H, Anne MNK, Eltobgy M, Dakhlallah D, Argwal S, Estfanous S, Zhang X, Partida-Sanchez S, Gavrilin MA, Jarjour WN, Amer AO. Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation. Front Immunol. 2019; 10: 2519.

                


                  Assani K, Shrestha CL, Rinehardt H, Zhang S, Robledo-Avila F, Wellmerling J, Partida-Sanchez S, Cormet-Boyaka E, Reynolds SD, Schlesinger LS, Kopp BT. AR-13 reduces antibiotic-resistant bacterial burden in cystic fibrosis phagocytes and improves cystic fibrosis transmembrane conductance regulator function. J Cyst Fibros. 2018 Oct 23;  

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Kopp BT, Amer AO, McCoy K, Bakaletz LO, Partida-Sanchez S. Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses. J Immunol. 2018 Oct 1; 201: 2016-2027.

                


                  Krause K, Kopp BT, Tazi MF, Caution K, Hamilton K, Badr A, Shrestha C, Tumin D, Hayes D Jr, Robledo-Avila F, Hall-Stoodley L, Klamer BG, Zhang X, Partida-Sanchez S, Parinandi NL, Kirkby SE, Dakhlallah D, McCoy KS, Cormet-Boyaka E, Amer AO. The expression of Mirc1/Mir17-92 cluster in sputum samples correlates with pulmonary exacerbations in cystic fibrosis patients. J Cyst Fibros. 2018 Jul; 17: 454-461.

                


                  Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15;  fj201800458.

                


                  Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, Delgado-Martin C, Partida-Sanchez S, Rodriguez-Fernandez JL, Nagy L, Tontonoz P, Castrillo A. LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis. Mol Cell Biol. 2018 Mar 5;  

                


                  Almasi S, Kennedy BE, El-Aghil M, Sterea AM, Gujar S, Partida-Sánchez S, El Hiani Y. TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway. J Biol Chem. 2018 Mar 9; 293: 3637-3650.

                


                  Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO. The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils. Sci Rep. 2017 Jun 9; 7: 3161.

                


                  Assani K, Shrestha CL, Robledo-Avila F, Rajaram MV, Partida-Sanchez S, Schlesinger LS, Kopp BT. Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by Burkholderia cenocepacia. J Immunol. 2017 Mar 1; 198: 1985-1994.

                


                  Beceiro S, Radin JN, Chatuvedi R, Piazuelo MB, Horvarth DJ, Cortado H, Gu Y, Dixon B, Gu C, Lange I, Koomoa DL, Wilson KT, Algood HM, Partida-Sánchez S. TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection. Mucosal Immunol. 2017 Mar; 10: 493-507.

                


                  Terrazas C, de Dios Ruiz-Rosado J, Amici SA, Jablonski KA, Martinez-Saucedo D, Webb LM, Cortado H, Robledo-Avila F, Oghumu S, Satoskar AR, Rodriguez-Sosa M, Terrazas LI, Guerau-de-Arellano M, Partida-Sánchez S. Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis. Sci Rep. 2017 Jan 17; 7: 40814.

View More Publications

Lab(s)

Center for Microbial Pathogenesis

My laboratory is interested in the study of immune cell recruitment induced by infection and/or inflammation. Our research projects are focused on molecular analyses of chemokine receptor-mediated G-protein-linked signaling and calcium influx in neutrophils and DCs. We are conducting experiments to study regulation of calcium influx mediated by CD38-catalyzed metabolites and the ADPR-activated calcium channel TRPM2 in inflammatory cells. We would like to assess whether CD38 inhibiting drugs, CD38-derived antagonists, and/or TRPM2 channel inhibitors, have potential therapeutic use to block undesired chronic inflammatory responses, or harmful T cell responses leading to autoimmunity. This knowledge could allow us to design new strategies for clinical intervention in several immunological disorders, as well as inflammatory and infectious diseases.

View My Publications

Publications

                  Zhang S, Shrestha CL, Robledo-Avila F, Jaganathan D, Wisniewski BL, Brown N, Pham H, Carey K, Amer AO, Hall-Stoodley L, McCoy KS, Bai S, Partida-Sanchez S, Kopp BT. Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor. Eur Respir J. 2022 Oct 20;  

                


                  Merchand-Reyes G, Santhanam R, Robledo-Avila FH, Weigel C, Ruiz-Rosado JD, Mo X, Partida-Sánchez S, Woyach JA, Oakes CC, Tridandapani S, Butchar JP. Disruption of Nurse-like Cell Differentiation as a Therapeutic Strategy for Chronic Lymphocytic Leukemia. J Immunol. 2022 Aug 22;  

                


                  Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis. Proc Natl Acad Sci U S A. 2022 May 24; 119: e2202012119.

                


                  Badr A, Eltobgy M, Krause K, Hamilton K, Estfanous S, Daily KP, Abu Khweek A, Hegazi A, Anne MNK, Carafice C, Robledo-Avila F, Saqr Y, Zhang X, Bonfield TL, Gavrilin MA, Partida-Sanchez S, Seveau S, Cormet-Boyaka E, Amer AO. CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages. Front Cell Infect Microbiol. 2022; 12: 819554.

                


                  Vargas-Roldán SY, Lezana-Fernández JL, Cerna-Cortés JF, Partida-Sánchez S, Santos-Preciado JI, Rosales-Reyes R. Fibrosis quística: patogenia bacteriana y moduladores del CFTR (regulador de conductancia transmembranal de la fibrosis quística). Bol Med Hosp Infant Mex. 2022; 79: 215-221.

                


                  Devaraj A, Novotny LA, Robledo-Avila FH, Buzzo JR, Mashburn-Warren L, Jurcisek JA, Tjokro NO, Partida-Sanchez S, Bakaletz LO, Goodman SD. The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation. J Clin Invest. 2021 Aug 16; 131: 

                


                  Yang C, Ruiz-Rosado JD, Robledo-Avila FH, Li Z, Jennings RN, Partida-Sanchez S, Montgomery CP. Antibody-Mediated Protection against Staphylococcus aureus Dermonecrosis: Synergy of Toxin Neutralization and Neutrophil Recruitment. J Invest Dermatol. 2021 Apr; 141: 810-820.e8.

                


                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

                


                  Partida-Sanchez S, Desai BN, Schwab A, Zierler S. Editorial: TRP Channels in Inflammation and Immunity. Front Immunol. 2021; 12: 684172.

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Partida-Sanchez S, Brockman KL. A Bacterial Epigenetic Switch in Non-typeable Haemophilus influenzae Modifies Host Immune Response During Otitis Media. Front Cell Infect Microbiol. 2020; 10: 512743.

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Partida-Sánchez S. The TRPM2 Ion Channel Regulates Inflammatory Functions of Neutrophils During Listeria monocytogenes Infection. Front Immunol. 2020; 11: 97.

                


                  Merchand-Reyes G, Robledo-Avila FH, Buteyn NJ, Gautam S, Santhanam R, Fatehchand K, Mo X, Partida-Sanchez S, Butchar JP, Tridandapani S. CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc?R-Mediated Signaling in Monocytes. J Immunol. 2019 Dec 15; 203: 3216-3224.

                


                  Sharma N, Dev R, Ruiz-Rosado JD, Partida-Sanchez S, Guerau-de-Arellano M, Dhakal P, Kuivaniemi H, Hans CP. Pharmacological inhibition of Notch signaling regresses pre-established abdominal aortic aneurysm. Sci Rep. 2019 Sep 17; 9: 13458.

                


                  Kopp BT, Fitch J, Jaramillo L, Shrestha CL, Robledo-Avila F, Zhang S, Palacios S, Woodley F, Hayes D Jr, Partida-Sanchez S, Ramilo O, White P, Mejias A. Whole-blood transcriptomic responses to lumacaftor/ivacaftor therapy in cystic fibrosis. J Cyst Fibros. 2019 Aug 29;  

                


                  Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.

                


                  Martínez-Saucedo D, Ruíz-Rosado JD, Terrazas C, Callejas BE, Satoskar AR, Partida-Sánchez S, Terrazas LI. Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages. J Immunol Res. 2019; 2019: 2946713.

                


                  Caution K, Young N, Robledo-Avila F, Krause K, Abu Khweek A, Hamilton K, Badr A, Vaidya A, Daily K, Gosu H, Anne MNK, Eltobgy M, Dakhlallah D, Argwal S, Estfanous S, Zhang X, Partida-Sanchez S, Gavrilin MA, Jarjour WN, Amer AO. Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation. Front Immunol. 2019; 10: 2519.

                


                  Assani K, Shrestha CL, Rinehardt H, Zhang S, Robledo-Avila F, Wellmerling J, Partida-Sanchez S, Cormet-Boyaka E, Reynolds SD, Schlesinger LS, Kopp BT. AR-13 reduces antibiotic-resistant bacterial burden in cystic fibrosis phagocytes and improves cystic fibrosis transmembrane conductance regulator function. J Cyst Fibros. 2018 Oct 23;  

                


                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Kopp BT, Amer AO, McCoy K, Bakaletz LO, Partida-Sanchez S. Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses. J Immunol. 2018 Oct 1; 201: 2016-2027.

                


                  Krause K, Kopp BT, Tazi MF, Caution K, Hamilton K, Badr A, Shrestha C, Tumin D, Hayes D Jr, Robledo-Avila F, Hall-Stoodley L, Klamer BG, Zhang X, Partida-Sanchez S, Parinandi NL, Kirkby SE, Dakhlallah D, McCoy KS, Cormet-Boyaka E, Amer AO. The expression of Mirc1/Mir17-92 cluster in sputum samples correlates with pulmonary exacerbations in cystic fibrosis patients. J Cyst Fibros. 2018 Jul; 17: 454-461.

                


                  Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15;  fj201800458.

                


                  Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, Delgado-Martin C, Partida-Sanchez S, Rodriguez-Fernandez JL, Nagy L, Tontonoz P, Castrillo A. LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis. Mol Cell Biol. 2018 Mar 5;  

                


                  Almasi S, Kennedy BE, El-Aghil M, Sterea AM, Gujar S, Partida-Sánchez S, El Hiani Y. TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway. J Biol Chem. 2018 Mar 9; 293: 3637-3650.

                


                  Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO. The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils. Sci Rep. 2017 Jun 9; 7: 3161.

                


                  Assani K, Shrestha CL, Robledo-Avila F, Rajaram MV, Partida-Sanchez S, Schlesinger LS, Kopp BT. Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by Burkholderia cenocepacia. J Immunol. 2017 Mar 1; 198: 1985-1994.

                


                  Beceiro S, Radin JN, Chatuvedi R, Piazuelo MB, Horvarth DJ, Cortado H, Gu Y, Dixon B, Gu C, Lange I, Koomoa DL, Wilson KT, Algood HM, Partida-Sánchez S. TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection. Mucosal Immunol. 2017 Mar; 10: 493-507.

                


                  Terrazas C, de Dios Ruiz-Rosado J, Amici SA, Jablonski KA, Martinez-Saucedo D, Webb LM, Cortado H, Robledo-Avila F, Oghumu S, Satoskar AR, Rodriguez-Sosa M, Terrazas LI, Guerau-de-Arellano M, Partida-Sánchez S. Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis. Sci Rep. 2017 Jan 17; 7: 40814.

View More Publications

Lab(s)

Center for Microbial Pathogenesis

My laboratory is interested in the study of immune cell recruitment induced by infection and/or inflammation. Our research projects are focused on molecular analyses of chemokine receptor-mediated G-protein-linked signaling and calcium influx in neutrophils and DCs. We are conducting experiments to study regulation of calcium influx mediated by CD38-catalyzed metabolites and the ADPR-activated calcium channel TRPM2 in inflammatory cells.

Lab(s)

Center for Microbial Pathogenesis

• Center for Microbial Pathogenesis

We would like to assess whether CD38 inhibiting drugs, CD38-derived antagonists, and/or TRPM2 channel inhibitors, have potential therapeutic use to block undesired chronic inflammatory responses, or harmful T cell responses leading to autoimmunity. This knowledge could allow us to design new strategies for clinical intervention in several immunological disorders, as well as inflammatory and infectious diseases.

• View My Publications

                  Zhang S, Shrestha CL, Robledo-Avila F, Jaganathan D, Wisniewski BL, Brown N, Pham H, Carey K, Amer AO, Hall-Stoodley L, McCoy KS, Bai S, Partida-Sanchez S, Kopp BT. Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor. Eur Respir J. 2022 Oct 20;  
  
  
  
                  Merchand-Reyes G, Santhanam R, Robledo-Avila FH, Weigel C, Ruiz-Rosado JD, Mo X, Partida-Sánchez S, Woyach JA, Oakes CC, Tridandapani S, Butchar JP. Disruption of Nurse-like Cell Differentiation as a Therapeutic Strategy for Chronic Lymphocytic Leukemia. J Immunol. 2022 Aug 22;  
  
  
  
                  Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis. Proc Natl Acad Sci U S A. 2022 May 24; 119: e2202012119.
  
  
  
                  Badr A, Eltobgy M, Krause K, Hamilton K, Estfanous S, Daily KP, Abu Khweek A, Hegazi A, Anne MNK, Carafice C, Robledo-Avila F, Saqr Y, Zhang X, Bonfield TL, Gavrilin MA, Partida-Sanchez S, Seveau S, Cormet-Boyaka E, Amer AO. CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages. Front Cell Infect Microbiol. 2022; 12: 819554.
  
  
  
                  Vargas-Roldán SY, Lezana-Fernández JL, Cerna-Cortés JF, Partida-Sánchez S, Santos-Preciado JI, Rosales-Reyes R. Fibrosis quística: patogenia bacteriana y moduladores del CFTR (regulador de conductancia transmembranal de la fibrosis quística). Bol Med Hosp Infant Mex. 2022; 79: 215-221.
  
  
  
                  Devaraj A, Novotny LA, Robledo-Avila FH, Buzzo JR, Mashburn-Warren L, Jurcisek JA, Tjokro NO, Partida-Sanchez S, Bakaletz LO, Goodman SD. The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation. J Clin Invest. 2021 Aug 16; 131: 
  
  
  
                  Yang C, Ruiz-Rosado JD, Robledo-Avila FH, Li Z, Jennings RN, Partida-Sanchez S, Montgomery CP. Antibody-Mediated Protection against Staphylococcus aureus Dermonecrosis: Synergy of Toxin Neutralization and Neutrophil Recruitment. J Invest Dermatol. 2021 Apr; 141: 810-820.e8.
  
  
  
                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.
  
  
  
                  Partida-Sanchez S, Desai BN, Schwab A, Zierler S. Editorial: TRP Channels in Inflammation and Immunity. Front Immunol. 2021; 12: 684172.
  
  
  
                  Robledo-Avila FH, Ruiz-Rosado JD, Partida-Sanchez S, Brockman KL. A Bacterial Epigenetic Switch in Non-typeable Haemophilus influenzae Modifies Host Immune Response During Otitis Media. Front Cell Infect Microbiol. 2020; 10: 512743.
  
  
  
                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Partida-Sánchez S. The TRPM2 Ion Channel Regulates Inflammatory Functions of Neutrophils During Listeria monocytogenes Infection. Front Immunol. 2020; 11: 97.
  
  
  
                  Merchand-Reyes G, Robledo-Avila FH, Buteyn NJ, Gautam S, Santhanam R, Fatehchand K, Mo X, Partida-Sanchez S, Butchar JP, Tridandapani S. CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc?R-Mediated Signaling in Monocytes. J Immunol. 2019 Dec 15; 203: 3216-3224.
  
  
  
                  Sharma N, Dev R, Ruiz-Rosado JD, Partida-Sanchez S, Guerau-de-Arellano M, Dhakal P, Kuivaniemi H, Hans CP. Pharmacological inhibition of Notch signaling regresses pre-established abdominal aortic aneurysm. Sci Rep. 2019 Sep 17; 9: 13458.
  
  
  
                  Kopp BT, Fitch J, Jaramillo L, Shrestha CL, Robledo-Avila F, Zhang S, Palacios S, Woodley F, Hayes D Jr, Partida-Sanchez S, Ramilo O, White P, Mejias A. Whole-blood transcriptomic responses to lumacaftor/ivacaftor therapy in cystic fibrosis. J Cyst Fibros. 2019 Aug 29;  
  
  
  
                  Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.
  
  
  
                  Martínez-Saucedo D, Ruíz-Rosado JD, Terrazas C, Callejas BE, Satoskar AR, Partida-Sánchez S, Terrazas LI. Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages. J Immunol Res. 2019; 2019: 2946713.
  
  
  
                  Caution K, Young N, Robledo-Avila F, Krause K, Abu Khweek A, Hamilton K, Badr A, Vaidya A, Daily K, Gosu H, Anne MNK, Eltobgy M, Dakhlallah D, Argwal S, Estfanous S, Zhang X, Partida-Sanchez S, Gavrilin MA, Jarjour WN, Amer AO. Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation. Front Immunol. 2019; 10: 2519.
  
  
  
                  Assani K, Shrestha CL, Rinehardt H, Zhang S, Robledo-Avila F, Wellmerling J, Partida-Sanchez S, Cormet-Boyaka E, Reynolds SD, Schlesinger LS, Kopp BT. AR-13 reduces antibiotic-resistant bacterial burden in cystic fibrosis phagocytes and improves cystic fibrosis transmembrane conductance regulator function. J Cyst Fibros. 2018 Oct 23;  
  
  
  
                  Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Kopp BT, Amer AO, McCoy K, Bakaletz LO, Partida-Sanchez S. Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses. J Immunol. 2018 Oct 1; 201: 2016-2027.
  
  
  
                  Krause K, Kopp BT, Tazi MF, Caution K, Hamilton K, Badr A, Shrestha C, Tumin D, Hayes D Jr, Robledo-Avila F, Hall-Stoodley L, Klamer BG, Zhang X, Partida-Sanchez S, Parinandi NL, Kirkby SE, Dakhlallah D, McCoy KS, Cormet-Boyaka E, Amer AO. The expression of Mirc1/Mir17-92 cluster in sputum samples correlates with pulmonary exacerbations in cystic fibrosis patients. J Cyst Fibros. 2018 Jul; 17: 454-461.
  
  
  
                  Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15;  fj201800458.
  
  
  
                  Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, Delgado-Martin C, Partida-Sanchez S, Rodriguez-Fernandez JL, Nagy L, Tontonoz P, Castrillo A. LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis. Mol Cell Biol. 2018 Mar 5;  
  
  
  
                  Almasi S, Kennedy BE, El-Aghil M, Sterea AM, Gujar S, Partida-Sánchez S, El Hiani Y. TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway. J Biol Chem. 2018 Mar 9; 293: 3637-3650.
  
  
  
                  Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO. The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils. Sci Rep. 2017 Jun 9; 7: 3161.
  
  
  
                  Assani K, Shrestha CL, Robledo-Avila F, Rajaram MV, Partida-Sanchez S, Schlesinger LS, Kopp BT. Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by Burkholderia cenocepacia. J Immunol. 2017 Mar 1; 198: 1985-1994.
  
  
  
                  Beceiro S, Radin JN, Chatuvedi R, Piazuelo MB, Horvarth DJ, Cortado H, Gu Y, Dixon B, Gu C, Lange I, Koomoa DL, Wilson KT, Algood HM, Partida-Sánchez S. TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection. Mucosal Immunol. 2017 Mar; 10: 493-507.
  
  
  
                  Terrazas C, de Dios Ruiz-Rosado J, Amici SA, Jablonski KA, Martinez-Saucedo D, Webb LM, Cortado H, Robledo-Avila F, Oghumu S, Satoskar AR, Rodriguez-Sosa M, Terrazas LI, Guerau-de-Arellano M, Partida-Sánchez S. Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis. Sci Rep. 2017 Jan 17; 7: 40814.
  
  

View More Publications

• Zhang S, Shrestha CL, Robledo-Avila F, Jaganathan D, Wisniewski BL, Brown N, Pham H, Carey K, Amer AO, Hall-Stoodley L, McCoy KS, Bai S, Partida-Sanchez S, Kopp BT. Cystic fibrosis macrophage function and clinical outcomes after elexacaftor/tezacaftor/ivacaftor. Eur Respir J. 2022 Oct 20;
• Merchand-Reyes G, Santhanam R, Robledo-Avila FH, Weigel C, Ruiz-Rosado JD, Mo X, Partida-Sánchez S, Woyach JA, Oakes CC, Tridandapani S, Butchar JP. Disruption of Nurse-like Cell Differentiation as a Therapeutic Strategy for Chronic Lymphocytic Leukemia. J Immunol. 2022 Aug 22;
• Eltobgy MM, Zani A, Kenney AD, Estfanous S, Kim E, Badr A, Carafice C, Daily K, Whitham O, Pietrzak M, Webb A, Kawahara J, Eddy AC, Denz P, Lu M, Kc M, Peeples ME, Li J, Zhu J, Que J, Robinson R, Rosas Mejia O, Rayner RE, Hall-Stoodley L, Seveau S, Gavrilin MA, Zhang X, Thomas J, Kohlmeier JE, Suthar MS, Oltz E, Tedeschi A, Robledo-Avila FH, Partida-Sanchez S, Hemann EA, Abdelrazik E, Forero A, Nimjee SM, Boyaka PN, Cormet-Boyaka E, Yount JS, Amer AO. Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and immunothrombosis. Proc Natl Acad Sci U S A. 2022 May 24; 119: e2202012119.
• Badr A, Eltobgy M, Krause K, Hamilton K, Estfanous S, Daily KP, Abu Khweek A, Hegazi A, Anne MNK, Carafice C, Robledo-Avila F, Saqr Y, Zhang X, Bonfield TL, Gavrilin MA, Partida-Sanchez S, Seveau S, Cormet-Boyaka E, Amer AO. CFTR Modulators Restore Acidification of Autophago-Lysosomes and Bacterial Clearance in Cystic Fibrosis Macrophages. Front Cell Infect Microbiol. 2022; 12: 819554.
• Vargas-Roldán SY, Lezana-Fernández JL, Cerna-Cortés JF, Partida-Sánchez S, Santos-Preciado JI, Rosales-Reyes R. Fibrosis quística: patogenia bacteriana y moduladores del CFTR (regulador de conductancia transmembranal de la fibrosis quística). Bol Med Hosp Infant Mex. 2022; 79: 215-221.
• Devaraj A, Novotny LA, Robledo-Avila FH, Buzzo JR, Mashburn-Warren L, Jurcisek JA, Tjokro NO, Partida-Sanchez S, Bakaletz LO, Goodman SD. The extracellular innate-immune effector HMGB1 limits pathogenic bacterial biofilm proliferation. J Clin Invest. 2021 Aug 16; 131:
• Yang C, Ruiz-Rosado JD, Robledo-Avila FH, Li Z, Jennings RN, Partida-Sanchez S, Montgomery CP. Antibody-Mediated Protection against Staphylococcus aureus Dermonecrosis: Synergy of Toxin Neutralization and Neutrophil Recruitment. J Invest Dermatol. 2021 Apr; 141: 810-820.e8.
• Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.
• Partida-Sanchez S, Desai BN, Schwab A, Zierler S. Editorial: TRP Channels in Inflammation and Immunity. Front Immunol. 2021; 12: 684172.
• Robledo-Avila FH, Ruiz-Rosado JD, Partida-Sanchez S, Brockman KL. A Bacterial Epigenetic Switch in Non-typeable Haemophilus influenzae Modifies Host Immune Response During Otitis Media. Front Cell Infect Microbiol. 2020; 10: 512743.
• Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Partida-Sánchez S. The TRPM2 Ion Channel Regulates Inflammatory Functions of Neutrophils During Listeria monocytogenes Infection. Front Immunol. 2020; 11: 97.
• Merchand-Reyes G, Robledo-Avila FH, Buteyn NJ, Gautam S, Santhanam R, Fatehchand K, Mo X, Partida-Sanchez S, Butchar JP, Tridandapani S. CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc?R-Mediated Signaling in Monocytes. J Immunol. 2019 Dec 15; 203: 3216-3224.
• Sharma N, Dev R, Ruiz-Rosado JD, Partida-Sanchez S, Guerau-de-Arellano M, Dhakal P, Kuivaniemi H, Hans CP. Pharmacological inhibition of Notch signaling regresses pre-established abdominal aortic aneurysm. Sci Rep. 2019 Sep 17; 9: 13458.
• Kopp BT, Fitch J, Jaramillo L, Shrestha CL, Robledo-Avila F, Zhang S, Palacios S, Woodley F, Hayes D Jr, Partida-Sanchez S, Ramilo O, White P, Mejias A. Whole-blood transcriptomic responses to lumacaftor/ivacaftor therapy in cystic fibrosis. J Cyst Fibros. 2019 Aug 29;
• Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.
• Martínez-Saucedo D, Ruíz-Rosado JD, Terrazas C, Callejas BE, Satoskar AR, Partida-Sánchez S, Terrazas LI. Taenia crassiceps-Excreted/Secreted Products Induce a Defined MicroRNA Profile that Modulates Inflammatory Properties of Macrophages. J Immunol Res. 2019; 2019: 2946713.
• Caution K, Young N, Robledo-Avila F, Krause K, Abu Khweek A, Hamilton K, Badr A, Vaidya A, Daily K, Gosu H, Anne MNK, Eltobgy M, Dakhlallah D, Argwal S, Estfanous S, Zhang X, Partida-Sanchez S, Gavrilin MA, Jarjour WN, Amer AO. Caspase-11 Mediates Neutrophil Chemotaxis and Extracellular Trap Formation During Acute Gouty Arthritis Through Alteration of Cofilin Phosphorylation. Front Immunol. 2019; 10: 2519.
• Assani K, Shrestha CL, Rinehardt H, Zhang S, Robledo-Avila F, Wellmerling J, Partida-Sanchez S, Cormet-Boyaka E, Reynolds SD, Schlesinger LS, Kopp BT. AR-13 reduces antibiotic-resistant bacterial burden in cystic fibrosis phagocytes and improves cystic fibrosis transmembrane conductance regulator function. J Cyst Fibros. 2018 Oct 23;
• Robledo-Avila FH, Ruiz-Rosado JD, Brockman KL, Kopp BT, Amer AO, McCoy K, Bakaletz LO, Partida-Sanchez S. Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses. J Immunol. 2018 Oct 1; 201: 2016-2027.
• Krause K, Kopp BT, Tazi MF, Caution K, Hamilton K, Badr A, Shrestha C, Tumin D, Hayes D Jr, Robledo-Avila F, Hall-Stoodley L, Klamer BG, Zhang X, Partida-Sanchez S, Parinandi NL, Kirkby SE, Dakhlallah D, McCoy KS, Cormet-Boyaka E, Amer AO. The expression of Mirc1/Mir17-92 cluster in sputum samples correlates with pulmonary exacerbations in cystic fibrosis patients. J Cyst Fibros. 2018 Jul; 17: 454-461.
• Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15; fj201800458.
• Beceiro S, Pap A, Czimmerer Z, Sallam T, Guillén JA, Gallardo G, Hong C, A-Gonzalez N, Tabraue C, Diaz M, Lopez F, Matalonga J, Valledor AF, Dominguez P, Ardavin C, Delgado-Martin C, Partida-Sanchez S, Rodriguez-Fernandez JL, Nagy L, Tontonoz P, Castrillo A. LXR nuclear receptors are transcriptional regulators of dendritic cell chemotaxis. Mol Cell Biol. 2018 Mar 5;
• Almasi S, Kennedy BE, El-Aghil M, Sterea AM, Gujar S, Partida-Sánchez S, El Hiani Y. TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway. J Biol Chem. 2018 Mar 9; 293: 3637-3650.
• Brockman KL, Branstool MT, Atack JM, Robledo-Avila F, Partida-Sanchez S, Jennings MP, Bakaletz LO. The ModA2 Phasevarion of nontypeable Haemophilus influenzae Regulates Resistance to Oxidative Stress and Killing by Human Neutrophils. Sci Rep. 2017 Jun 9; 7: 3161.
• Assani K, Shrestha CL, Robledo-Avila F, Rajaram MV, Partida-Sanchez S, Schlesinger LS, Kopp BT. Human Cystic Fibrosis Macrophages Have Defective Calcium-Dependent Protein Kinase C Activation of the NADPH Oxidase, an Effect Augmented by Burkholderia cenocepacia. J Immunol. 2017 Mar 1; 198: 1985-1994.
• Beceiro S, Radin JN, Chatuvedi R, Piazuelo MB, Horvarth DJ, Cortado H, Gu Y, Dixon B, Gu C, Lange I, Koomoa DL, Wilson KT, Algood HM, Partida-Sánchez S. TRPM2 ion channels regulate macrophage polarization and gastric inflammation during Helicobacter pylori infection. Mucosal Immunol. 2017 Mar; 10: 493-507.
• Terrazas C, de Dios Ruiz-Rosado J, Amici SA, Jablonski KA, Martinez-Saucedo D, Webb LM, Cortado H, Robledo-Avila F, Oghumu S, Satoskar AR, Rodriguez-Sosa M, Terrazas LI, Guerau-de-Arellano M, Partida-Sánchez S. Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis. Sci Rep. 2017 Jan 17; 7: 40814.

Biography

        Santiago Partida-Sanchez, PhD is a Principal Investigator at The Research Institute at Nationwide Children’s Hospital.  He is an Associate Professor of Pediatrics at the Ohio State University College of Medicine.  Dr. Partida-Sanchez’s NIH funded research program focuses on identifying mechanisms of activation of calcium cellular signals via TRP type ion channels. His team's goal is to elucidate how those pathways impact on the functions of innate immune cells, such as macrophages and dendritic cells.  Dr. Partida-Sanchez's research will provide insights into how inflammatory cells are recruited during infection or inflammation, and will help to develop cellular migration inhibitors with therapeutic potential.

Biography

        Santiago Partida-Sanchez, PhD is a Principal Investigator at The Research Institute at Nationwide Children’s Hospital.  He is an Associate Professor of Pediatrics at the Ohio State University College of Medicine.  Dr. Partida-Sanchez’s NIH funded research program focuses on identifying mechanisms of activation of calcium cellular signals via TRP type ion channels. His team's goal is to elucidate how those pathways impact on the functions of innate immune cells, such as macrophages and dendritic cells.  Dr. Partida-Sanchez's research will provide insights into how inflammatory cells are recruited during infection or inflammation, and will help to develop cellular migration inhibitors with therapeutic potential.

Biography

        Santiago Partida-Sanchez, PhD is a Principal Investigator at The Research Institute at Nationwide Children’s Hospital.  He is an Associate Professor of Pediatrics at the Ohio State University College of Medicine.  Dr. Partida-Sanchez’s NIH funded research program focuses on identifying mechanisms of activation of calcium cellular signals via TRP type ion channels. His team's goal is to elucidate how those pathways impact on the functions of innate immune cells, such as macrophages and dendritic cells.  Dr. Partida-Sanchez's research will provide insights into how inflammatory cells are recruited during infection or inflammation, and will help to develop cellular migration inhibitors with therapeutic potential.



      






        Santiago Partida-Sanchez, PhD is a Principal Investigator at The Research Institute at Nationwide Children’s Hospital.  He is an Associate Professor of Pediatrics at the Ohio State University College of Medicine.  Dr. Partida-Sanchez’s NIH funded research program focuses on identifying mechanisms of activation of calcium cellular signals via TRP type ion channels. His team's goal is to elucidate how those pathways impact on the functions of innate immune cells, such as macrophages and dendritic cells.  Dr. Partida-Sanchez's research will provide insights into how inflammatory cells are recruited during infection or inflammation, and will help to develop cellular migration inhibitors with therapeutic potential.

Academic and Clinical Areas

Center for Microbial Pathogenesis

Principal Investigator

Primary Department

Microbial Pathogenesis

Academic and Clinical Areas

Center for Microbial Pathogenesis

Principal Investigator

Primary Department

Microbial Pathogenesis

Academic and Clinical Areas

Center for Microbial Pathogenesis

Principal Investigator

Primary Department

Microbial Pathogenesis

Center for Microbial Pathogenesis

Principal Investigator

Primary Department

Microbial Pathogenesis

• Center for Microbial Pathogenesis
• Principal Investigator
• Primary Department
• Microbial Pathogenesis

Professional Experience

2011 - Present The Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Public Health, Associate Professor of Pediatrics2004 - Present Integrated Biomedical Science Graduate Program and Molecular, Cellular and Development Biology Program, The Ohio State University, College of Medicine and Public Health, Graduate Faculty Member2004 - 2011 The Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Public Health, Assistant Professor of Pediatrics2003 - 2004 The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund., Research Scientist1998 - 2003 The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund., Post-Doctoral Fellow

Professional Experience

2011 - Present The Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Public Health, Associate Professor of Pediatrics2004 - Present Integrated Biomedical Science Graduate Program and Molecular, Cellular and Development Biology Program, The Ohio State University, College of Medicine and Public Health, Graduate Faculty Member2004 - 2011 The Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Public Health, Assistant Professor of Pediatrics2003 - 2004 The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund., Research Scientist1998 - 2003 The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund., Post-Doctoral Fellow

Professional Experience

2011 - Present The Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Public Health, Associate Professor of Pediatrics2004 - Present Integrated Biomedical Science Graduate Program and Molecular, Cellular and Development Biology Program, The Ohio State University, College of Medicine and Public Health, Graduate Faculty Member2004 - 2011 The Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Public Health, Assistant Professor of Pediatrics2003 - 2004 The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund., Research Scientist1998 - 2003 The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund., Post-Doctoral Fellow

2011 - Present The Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Public Health, Associate Professor of Pediatrics2004 - Present Integrated Biomedical Science Graduate Program and Molecular, Cellular and Development Biology Program, The Ohio State University, College of Medicine and Public Health, Graduate Faculty Member2004 - 2011 The Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Public Health, Assistant Professor of Pediatrics2003 - 2004 The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund., Research Scientist1998 - 2003 The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund., Post-Doctoral Fellow

2011 - Present The Research Institute at Nationwide Children’s Hospital, The Ohio State University, College of Medicine and Public Health, Associate Professor of Pediatrics

Contact Information

Microbial Pathogenesis

Call us at: (614)722.4092

Fax us at: (614)722.2818

Email Santiago Partida Sanchez

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Contact Information

Microbial Pathogenesis

Call us at: (614)722.4092

Fax us at: (614)722.2818

Email Santiago Partida Sanchez

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Contact Information

Microbial Pathogenesis

Call us at: (614)722.4092

Fax us at: (614)722.2818

Email Santiago Partida Sanchez

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Microbial Pathogenesis

Call us at: (614)722.4092

Fax us at: (614)722.2818

Email Santiago Partida Sanchez

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Call us at: (614)722.4092

Fax us at: (614)722.2818

Email Santiago Partida Sanchez

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Call us at: (614)722.4092

Fax us at: (614)722.2818

Email Santiago Partida Sanchez

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

• Call us at:
• (614)722.4092
• Fax us at:
• (614)722.2818
• Email Santiago Partida Sanchez
• Abigail Wexner Research Institute700 Children’s DriveColumbus, Ohio 43205 (map)