Ruoning Wang

Contact Information

Call us at: (614)355-2980

Fax us at: (614)722-5895

Center for Childhood Cancer700 Children’s Drive Room WA5016Columbus, Ohio 43205 (map)

Learn more about Ruoning Wang

Biography

Ruoning Wang, PhD, is a principal investigator in the Center for Childhood Cancer for The Research Institute at Nationwide Children’s Hospital, a principal investigator for the Division of Hematology and Oncology at Nationwide Children’s Hospital and an assistant professor in the Department of Pediatrics at The Ohio State University College of Medicine. Dr. Wang earned his bachelor’s degree in Medicinal Chemistry from China Pharmaceutical University, followed by an MS degree in Biochemistry from Nanjing Medical University and a PhD degree in Gene & Development from the University of Texas, MD Anderson Cancer Center (UT-MDACC). He trained in Immunology and Cancer Biology at St Jude Children’s Research Hospital as a postdoctoral fellow and joined The Research Institute at Nationwide Children’s Hospital as a princial investigator and The Ohio State University as an assistant professor of pediatrics in August 2013.

Academic and Clinical Areas

Center for Childhood Cancer

Principal Investigator

Hematology/Oncology & BMT

Principal Investigator

Primary Department

Center for Childhood Cancer

Awards, Honors & Organizations

V Scholar, 2014 AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award, American Cancer Society, 2011 Alfred G. Knudson Outstanding Dissertation Award, UT-MD Anderson Cancer Center, 2007 Presidents’ Research Scholar Award, UTH-GSBS and UT-MD Anderson Cancer Center, 2007 Research Achievement Award (1st Place), Genes & Development Program, UT-MD Anderson Cancer Center, 2006 George J. Mitchell Fellowship, St. Jude Children’s Research Hospital, 2009 - 2012

Research

Lab(s)

Center for Childhood Cancer

Our lab’s fundamental interest is to understand how eukaryotic cells integrate various extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). We address our questions in patho-physiological context such as tumorigenesis and immune response. In particular, we focus on understanding the impact of the interplay between cell metabolic programs and cell signaling programs on tumorigenesis and immunity. We apply various experimental models, each of which has unique scientific features, such as mouse models of human tumor and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessible for direct intracellular injection of biological material), various primary cells from mouse (MEFs, T, B cell and macrophage), and human transformed cell lines (provide unique cellular tools to understand the potential cellular mechanisms that may mimic what happen in vivo). Publications

                  Kang S, Liu L, Wang T, Cannon M, Lin P, Fan TW, Scott DA, Wu HJ, Lane AN, Wang R. GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation. Nat Metab. 2022 Oct; 4: 1322-1335.

                


                  Zhang P, Brinton LT, Gharghabi M, Sher S, Williams K, Cannon M, Walker JS, Canfield D, Beaver L, Cempre CB, Phillips H, Chen X, Yan P, Lehman A, Scherle P, Wang M, Vaddi K, Baiocchi R, Wang R, Sampath D, Alinari L, Blachly JS, Lapalombella R. Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions. Sci Adv. 2022 Sep 16; 8: eabp9005.

                


                  Tan T, Wu C, Liu B, Pan BF, Hawke DH, Su Z, Liu S, Zhang W, Wang R, Lin SH, Kuang J. Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators. Mol Biol Cell. 2022 Aug 17;  mbcE22040118.

                


                  Singh S, Abu-Zaid A, Jin H, Fang J, Wu Q, Wang T, Feng H, Quarni W, Shao Y, Maxham L, Abdolvahabi A, Yun MK, Vaithiyalingam S, Tan H, Bowling J, Honnell V, Young B, Guo Y, Bajpai R, Pruett-Miller SM, Grosveld GC, Hatley M, Xu B, Fan Y, Wu G, Chen EY, Chen T, Lewis PW, Rankovic Z, Li Y, Murphy AJ, Easton J, Peng J, Chen X, Wang R, White SW, Davidoff AM, Yang J. Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. Sci Transl Med. 2022 Jul 13; 14: eabq2096.

                


                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.

                


                  Khurshid S, Montes M, Comiskey DF Jr, Shane B, Matsa E, Jung F, Brown C, Bid HK, Wang R, Houghton PJ, Roberts R, Rigo F, Chandler D. Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma. NPJ Precis Oncol. 2022 Jan 11; 6: 1.

                


                  Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Sci Adv. 2021 Nov 19; 7: eabj5405.

                


                  Wang Y, Wang F, Wang L, Qiu S, Yao Y, Yan C, Xiong X, Chen X, Ji Q, Cao J, Gao G, Li D, Zhang L, Guo Z, Wang R, Wang H, Fan G. NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells. Cell Rep. 2021 Aug 10; 36: 109516.

                


                  Kang S, Wu R, Wang R. A Simple and Robust Protocol for in vitro Differentiation of Mouse Non-pathogenic T Helper 17 Cells from CD4+ T Cells. Bio Protoc. 2021 May 20; 11: e4029.

                


                  Jia A, Wang Y, Wang Y, Li Y, Yang Q, Cao Y, He Y, Dong L, Dong Y, Hou Y, Wang R, Bi Y, Liu G. The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer. Cell Mol Immunol. 2021 Apr; 18: 1074-1076.

                


                  Lee J, Ghonime MG, Wang R, Cassady KA. The Antiviral Apparatus: STING and Oncolytic Virus Restriction. Mol Ther Oncolytics. 2019 Jun 28; 13: 7-13.

                


                  Yan J, Wang R, Horng T. mTOR Is Key to T Cell Transdifferentiation. Cell Metab. 2019 Feb 5; 29: 241-242.

                


                  Schafer JR, Salzillo TC, Chakravarti N, Kararoudi MN, Trikha P, Foltz JA, Wang R, Li S, Lee DA. Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells. J Allergy Clin Immunol. 2019 Jan; 143: 346-358.e6.

                


                  Xu X, Gnanaprakasam JNR, Sherman J, Wang R. A Metabolism Toolbox for CAR T Therapy. Front Oncol. 2019; 9: 322.

                


                  Lian G, Gnanaprakasam JR, Wang T, Wu R, Chen X, Liu L, Shen Y, Yang M, Yang J, Chen Y, Vasiliou V, Cassel TA, Green DR, Liu Y, Fan TW, Wang R. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. Elife. 2018 Sep 10; 7: 

                


                  Lu Y, Liu H, Bi Y, Yang H, Li Y, Wang J, Zhang Z, Wang Y, Li C, Jia A, Han L, Hu Y, Zhao Y, Wang R, Liu G. Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1a-dependent glycolysis. Cell Mol Immunol. 2018 Jun; 15: 618-629.

                


                  Shen Y, Sherman JW, Chen X, Wang R. Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition. J Biol Chem. 2018 Apr 6; 293: 5185-5199.

                


                  Wang T, Liu L, Chen X, Shen Y, Lian G, Shah N, Davidoff AM, Yang J, Wang R. MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent. Cell Death Dis. 2018 Feb 14; 9: 220.

                


                  Rashida Gnanaprakasam JN, Wu R, Wang R. Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity. Front Immunol. 2018; 9: 1075.

                


                  Yang J, Milasta S, Hu D, AlTahan AM, Interiano RB, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani AC, Wang R, Wang Y, Ong SS, Boyd VA, Young B, Das S, Shelat A, Wu Y, Li Z, Zheng JJ, Mishra A, Cheng Y, Qu C, Peng J, Green DR, White S, Guy RK, Chen T, Davidoff AM. Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox. Cancer Res. 2017 Sep 1; 77: 4626-4638.

                


                  Shen Y, Vignali P, Wang R. Rapid Profiling Cell Cycle by Flow Cytometry Using Concurrent Staining of DNA and Mitotic Markers. Bio Protoc. 2017 Aug 20; 7: 

                


                  Yao Q, Gutierrez DC, Hoang NH, Kim D, Wang R, Hobbs C, Zhu L. Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles. Mol Pharm. 2017 Jul 3; 14: 2378-2389.

View More Publications

Professional Experience

1996 - 1996 Nanjing Medical University, Teacher

Contact Information

Center for Childhood Cancer

Call us at: (614)355-2980

Fax us at: (614)722-5895

                    700 Children's Drive Room WA5016Columbus, Ohio 43205 (map)

Contact Information

Call us at: (614)355-2980

Fax us at: (614)722-5895

Center for Childhood Cancer700 Children’s Drive Room WA5016Columbus, Ohio 43205 (map)

Learn more about Ruoning Wang

Biography

Ruoning Wang, PhD, is a principal investigator in the Center for Childhood Cancer for The Research Institute at Nationwide Children’s Hospital, a principal investigator for the Division of Hematology and Oncology at Nationwide Children’s Hospital and an assistant professor in the Department of Pediatrics at The Ohio State University College of Medicine. Dr. Wang earned his bachelor’s degree in Medicinal Chemistry from China Pharmaceutical University, followed by an MS degree in Biochemistry from Nanjing Medical University and a PhD degree in Gene & Development from the University of Texas, MD Anderson Cancer Center (UT-MDACC). He trained in Immunology and Cancer Biology at St Jude Children’s Research Hospital as a postdoctoral fellow and joined The Research Institute at Nationwide Children’s Hospital as a princial investigator and The Ohio State University as an assistant professor of pediatrics in August 2013.

Academic and Clinical Areas

Center for Childhood Cancer

Principal Investigator

Hematology/Oncology & BMT

Principal Investigator

Primary Department

Center for Childhood Cancer

Awards, Honors & Organizations

V Scholar, 2014 AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award, American Cancer Society, 2011 Alfred G. Knudson Outstanding Dissertation Award, UT-MD Anderson Cancer Center, 2007 Presidents’ Research Scholar Award, UTH-GSBS and UT-MD Anderson Cancer Center, 2007 Research Achievement Award (1st Place), Genes & Development Program, UT-MD Anderson Cancer Center, 2006 George J. Mitchell Fellowship, St. Jude Children’s Research Hospital, 2009 - 2012

Research

Lab(s)

Center for Childhood Cancer

Our lab’s fundamental interest is to understand how eukaryotic cells integrate various extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). We address our questions in patho-physiological context such as tumorigenesis and immune response. In particular, we focus on understanding the impact of the interplay between cell metabolic programs and cell signaling programs on tumorigenesis and immunity. We apply various experimental models, each of which has unique scientific features, such as mouse models of human tumor and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessible for direct intracellular injection of biological material), various primary cells from mouse (MEFs, T, B cell and macrophage), and human transformed cell lines (provide unique cellular tools to understand the potential cellular mechanisms that may mimic what happen in vivo). Publications

                  Kang S, Liu L, Wang T, Cannon M, Lin P, Fan TW, Scott DA, Wu HJ, Lane AN, Wang R. GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation. Nat Metab. 2022 Oct; 4: 1322-1335.

                


                  Zhang P, Brinton LT, Gharghabi M, Sher S, Williams K, Cannon M, Walker JS, Canfield D, Beaver L, Cempre CB, Phillips H, Chen X, Yan P, Lehman A, Scherle P, Wang M, Vaddi K, Baiocchi R, Wang R, Sampath D, Alinari L, Blachly JS, Lapalombella R. Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions. Sci Adv. 2022 Sep 16; 8: eabp9005.

                


                  Tan T, Wu C, Liu B, Pan BF, Hawke DH, Su Z, Liu S, Zhang W, Wang R, Lin SH, Kuang J. Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators. Mol Biol Cell. 2022 Aug 17;  mbcE22040118.

                


                  Singh S, Abu-Zaid A, Jin H, Fang J, Wu Q, Wang T, Feng H, Quarni W, Shao Y, Maxham L, Abdolvahabi A, Yun MK, Vaithiyalingam S, Tan H, Bowling J, Honnell V, Young B, Guo Y, Bajpai R, Pruett-Miller SM, Grosveld GC, Hatley M, Xu B, Fan Y, Wu G, Chen EY, Chen T, Lewis PW, Rankovic Z, Li Y, Murphy AJ, Easton J, Peng J, Chen X, Wang R, White SW, Davidoff AM, Yang J. Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. Sci Transl Med. 2022 Jul 13; 14: eabq2096.

                


                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.

                


                  Khurshid S, Montes M, Comiskey DF Jr, Shane B, Matsa E, Jung F, Brown C, Bid HK, Wang R, Houghton PJ, Roberts R, Rigo F, Chandler D. Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma. NPJ Precis Oncol. 2022 Jan 11; 6: 1.

                


                  Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Sci Adv. 2021 Nov 19; 7: eabj5405.

                


                  Wang Y, Wang F, Wang L, Qiu S, Yao Y, Yan C, Xiong X, Chen X, Ji Q, Cao J, Gao G, Li D, Zhang L, Guo Z, Wang R, Wang H, Fan G. NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells. Cell Rep. 2021 Aug 10; 36: 109516.

                


                  Kang S, Wu R, Wang R. A Simple and Robust Protocol for in vitro Differentiation of Mouse Non-pathogenic T Helper 17 Cells from CD4+ T Cells. Bio Protoc. 2021 May 20; 11: e4029.

                


                  Jia A, Wang Y, Wang Y, Li Y, Yang Q, Cao Y, He Y, Dong L, Dong Y, Hou Y, Wang R, Bi Y, Liu G. The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer. Cell Mol Immunol. 2021 Apr; 18: 1074-1076.

                


                  Lee J, Ghonime MG, Wang R, Cassady KA. The Antiviral Apparatus: STING and Oncolytic Virus Restriction. Mol Ther Oncolytics. 2019 Jun 28; 13: 7-13.

                


                  Yan J, Wang R, Horng T. mTOR Is Key to T Cell Transdifferentiation. Cell Metab. 2019 Feb 5; 29: 241-242.

                


                  Schafer JR, Salzillo TC, Chakravarti N, Kararoudi MN, Trikha P, Foltz JA, Wang R, Li S, Lee DA. Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells. J Allergy Clin Immunol. 2019 Jan; 143: 346-358.e6.

                


                  Xu X, Gnanaprakasam JNR, Sherman J, Wang R. A Metabolism Toolbox for CAR T Therapy. Front Oncol. 2019; 9: 322.

                


                  Lian G, Gnanaprakasam JR, Wang T, Wu R, Chen X, Liu L, Shen Y, Yang M, Yang J, Chen Y, Vasiliou V, Cassel TA, Green DR, Liu Y, Fan TW, Wang R. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. Elife. 2018 Sep 10; 7: 

                


                  Lu Y, Liu H, Bi Y, Yang H, Li Y, Wang J, Zhang Z, Wang Y, Li C, Jia A, Han L, Hu Y, Zhao Y, Wang R, Liu G. Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1a-dependent glycolysis. Cell Mol Immunol. 2018 Jun; 15: 618-629.

                


                  Shen Y, Sherman JW, Chen X, Wang R. Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition. J Biol Chem. 2018 Apr 6; 293: 5185-5199.

                


                  Wang T, Liu L, Chen X, Shen Y, Lian G, Shah N, Davidoff AM, Yang J, Wang R. MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent. Cell Death Dis. 2018 Feb 14; 9: 220.

                


                  Rashida Gnanaprakasam JN, Wu R, Wang R. Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity. Front Immunol. 2018; 9: 1075.

                


                  Yang J, Milasta S, Hu D, AlTahan AM, Interiano RB, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani AC, Wang R, Wang Y, Ong SS, Boyd VA, Young B, Das S, Shelat A, Wu Y, Li Z, Zheng JJ, Mishra A, Cheng Y, Qu C, Peng J, Green DR, White S, Guy RK, Chen T, Davidoff AM. Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox. Cancer Res. 2017 Sep 1; 77: 4626-4638.

                


                  Shen Y, Vignali P, Wang R. Rapid Profiling Cell Cycle by Flow Cytometry Using Concurrent Staining of DNA and Mitotic Markers. Bio Protoc. 2017 Aug 20; 7: 

                


                  Yao Q, Gutierrez DC, Hoang NH, Kim D, Wang R, Hobbs C, Zhu L. Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles. Mol Pharm. 2017 Jul 3; 14: 2378-2389.

View More Publications

Professional Experience

1996 - 1996 Nanjing Medical University, Teacher

Contact Information

Center for Childhood Cancer

Call us at: (614)355-2980

Fax us at: (614)722-5895

                    700 Children's Drive Room WA5016Columbus, Ohio 43205 (map)

Contact Information

Call us at: (614)355-2980

Fax us at: (614)722-5895

Center for Childhood Cancer700 Children’s Drive Room WA5016Columbus, Ohio 43205 (map)

Learn more about Ruoning Wang

Contact Information

• Call us at:
• (614)355-2980
• Fax us at:
• (614)722-5895
• Center for Childhood Cancer700 Children’s Drive Room WA5016Columbus, Ohio 43205 (map)

Learn more about Ruoning Wang

Biography

Ruoning Wang, PhD, is a principal investigator in the Center for Childhood Cancer for The Research Institute at Nationwide Children’s Hospital, a principal investigator for the Division of Hematology and Oncology at Nationwide Children’s Hospital and an assistant professor in the Department of Pediatrics at The Ohio State University College of Medicine. Dr. Wang earned his bachelor’s degree in Medicinal Chemistry from China Pharmaceutical University, followed by an MS degree in Biochemistry from Nanjing Medical University and a PhD degree in Gene & Development from the University of Texas, MD Anderson Cancer Center (UT-MDACC). He trained in Immunology and Cancer Biology at St Jude Children’s Research Hospital as a postdoctoral fellow and joined The Research Institute at Nationwide Children’s Hospital as a princial investigator and The Ohio State University as an assistant professor of pediatrics in August 2013.

Biography

Ruoning Wang, PhD, is a principal investigator in the Center for Childhood Cancer for The Research Institute at Nationwide Children’s Hospital, a principal investigator for the Division of Hematology and Oncology at Nationwide Children’s Hospital and an assistant professor in the Department of Pediatrics at The Ohio State University College of Medicine. Dr. Wang earned his bachelor’s degree in Medicinal Chemistry from China Pharmaceutical University, followed by an MS degree in Biochemistry from Nanjing Medical University and a PhD degree in Gene & Development from the University of Texas, MD Anderson Cancer Center (UT-MDACC). He trained in Immunology and Cancer Biology at St Jude Children’s Research Hospital as a postdoctoral fellow and joined The Research Institute at Nationwide Children’s Hospital as a princial investigator and The Ohio State University as an assistant professor of pediatrics in August 2013.

Biography

Ruoning Wang, PhD, is a principal investigator in the Center for Childhood Cancer for The Research Institute at Nationwide Children’s Hospital, a principal investigator for the Division of Hematology and Oncology at Nationwide Children’s Hospital and an assistant professor in the Department of Pediatrics at The Ohio State University College of Medicine. Dr. Wang earned his bachelor’s degree in Medicinal Chemistry from China Pharmaceutical University, followed by an MS degree in Biochemistry from Nanjing Medical University and a PhD degree in Gene & Development from the University of Texas, MD Anderson Cancer Center (UT-MDACC). He trained in Immunology and Cancer Biology at St Jude Children’s Research Hospital as a postdoctoral fellow and joined The Research Institute at Nationwide Children’s Hospital as a princial investigator and The Ohio State University as an assistant professor of pediatrics in August 2013.

Ruoning Wang, PhD, is a principal investigator in the Center for Childhood Cancer for The Research Institute at Nationwide Children’s Hospital, a principal investigator for the Division of Hematology and Oncology at Nationwide Children’s Hospital and an assistant professor in the Department of Pediatrics at The Ohio State University College of Medicine. Dr. Wang earned his bachelor’s degree in Medicinal Chemistry from China Pharmaceutical University, followed by an MS degree in Biochemistry from Nanjing Medical University and a PhD degree in Gene & Development from the University of Texas, MD Anderson Cancer Center (UT-MDACC). He trained in Immunology and Cancer Biology at St Jude Children’s Research Hospital as a postdoctoral fellow and joined The Research Institute at Nationwide Children’s Hospital as a princial investigator and The Ohio State University as an assistant professor of pediatrics in August 2013.

Ruoning Wang, PhD, is a principal investigator in the Center for Childhood Cancer for The Research Institute at Nationwide Children’s Hospital, a principal investigator for the Division of Hematology and Oncology at Nationwide Children’s Hospital and an assistant professor in the Department of Pediatrics at The Ohio State University College of Medicine.

Dr. Wang earned his bachelor’s degree in Medicinal Chemistry from China Pharmaceutical University, followed by an MS degree in Biochemistry from Nanjing Medical University and a PhD degree in Gene & Development from the University of Texas, MD Anderson Cancer Center (UT-MDACC). He trained in Immunology and Cancer Biology at St Jude Children’s Research Hospital as a postdoctoral fellow and joined The Research Institute at Nationwide Children’s Hospital as a princial investigator and The Ohio State University as an assistant professor of pediatrics in August 2013.

Academic and Clinical Areas

Center for Childhood Cancer

Principal Investigator

Hematology/Oncology & BMT

Principal Investigator

Primary Department

Center for Childhood Cancer

Academic and Clinical Areas

Center for Childhood Cancer

Principal Investigator

Hematology/Oncology & BMT

Principal Investigator

Primary Department

Center for Childhood Cancer

Academic and Clinical Areas

Center for Childhood Cancer

Principal Investigator

Hematology/Oncology & BMT

Principal Investigator

Primary Department

Center for Childhood Cancer

Center for Childhood Cancer

Principal Investigator

Hematology/Oncology & BMT

Principal Investigator

Primary Department

Center for Childhood Cancer

• Center for Childhood Cancer
• Principal Investigator
• Hematology/Oncology & BMT
• Principal Investigator
• Primary Department
• Center for Childhood Cancer

Awards, Honors & Organizations

V Scholar, 2014 AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award, American Cancer Society, 2011 Alfred G. Knudson Outstanding Dissertation Award, UT-MD Anderson Cancer Center, 2007 Presidents’ Research Scholar Award, UTH-GSBS and UT-MD Anderson Cancer Center, 2007 Research Achievement Award (1st Place), Genes & Development Program, UT-MD Anderson Cancer Center, 2006 George J. Mitchell Fellowship, St. Jude Children’s Research Hospital, 2009 - 2012

Awards, Honors & Organizations

V Scholar, 2014 AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award, American Cancer Society, 2011 Alfred G. Knudson Outstanding Dissertation Award, UT-MD Anderson Cancer Center, 2007 Presidents’ Research Scholar Award, UTH-GSBS and UT-MD Anderson Cancer Center, 2007 Research Achievement Award (1st Place), Genes & Development Program, UT-MD Anderson Cancer Center, 2006 George J. Mitchell Fellowship, St. Jude Children’s Research Hospital, 2009 - 2012

Awards, Honors & Organizations

V Scholar, 2014 AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award, American Cancer Society, 2011 Alfred G. Knudson Outstanding Dissertation Award, UT-MD Anderson Cancer Center, 2007 Presidents’ Research Scholar Award, UTH-GSBS and UT-MD Anderson Cancer Center, 2007 Research Achievement Award (1st Place), Genes & Development Program, UT-MD Anderson Cancer Center, 2006 George J. Mitchell Fellowship, St. Jude Children’s Research Hospital, 2009 - 2012

V Scholar, 2014 AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award, American Cancer Society, 2011 Alfred G. Knudson Outstanding Dissertation Award, UT-MD Anderson Cancer Center, 2007 Presidents’ Research Scholar Award, UTH-GSBS and UT-MD Anderson Cancer Center, 2007 Research Achievement Award (1st Place), Genes & Development Program, UT-MD Anderson Cancer Center, 2006 George J. Mitchell Fellowship, St. Jude Children’s Research Hospital, 2009 - 2012

• V Scholar, 2014
• AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award, American Cancer Society, 2011
• Alfred G. Knudson Outstanding Dissertation Award, UT-MD Anderson Cancer Center, 2007
• Presidents’ Research Scholar Award, UTH-GSBS and UT-MD Anderson Cancer Center, 2007
• Research Achievement Award (1st Place), Genes & Development Program, UT-MD Anderson Cancer Center, 2006
• George J. Mitchell Fellowship, St. Jude Children’s Research Hospital, 2009 - 2012

Research

Lab(s)

Center for Childhood Cancer

Our lab’s fundamental interest is to understand how eukaryotic cells integrate various extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). We address our questions in patho-physiological context such as tumorigenesis and immune response. In particular, we focus on understanding the impact of the interplay between cell metabolic programs and cell signaling programs on tumorigenesis and immunity. We apply various experimental models, each of which has unique scientific features, such as mouse models of human tumor and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessible for direct intracellular injection of biological material), various primary cells from mouse (MEFs, T, B cell and macrophage), and human transformed cell lines (provide unique cellular tools to understand the potential cellular mechanisms that may mimic what happen in vivo). Publications

                  Kang S, Liu L, Wang T, Cannon M, Lin P, Fan TW, Scott DA, Wu HJ, Lane AN, Wang R. GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation. Nat Metab. 2022 Oct; 4: 1322-1335.

                


                  Zhang P, Brinton LT, Gharghabi M, Sher S, Williams K, Cannon M, Walker JS, Canfield D, Beaver L, Cempre CB, Phillips H, Chen X, Yan P, Lehman A, Scherle P, Wang M, Vaddi K, Baiocchi R, Wang R, Sampath D, Alinari L, Blachly JS, Lapalombella R. Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions. Sci Adv. 2022 Sep 16; 8: eabp9005.

                


                  Tan T, Wu C, Liu B, Pan BF, Hawke DH, Su Z, Liu S, Zhang W, Wang R, Lin SH, Kuang J. Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators. Mol Biol Cell. 2022 Aug 17;  mbcE22040118.

                


                  Singh S, Abu-Zaid A, Jin H, Fang J, Wu Q, Wang T, Feng H, Quarni W, Shao Y, Maxham L, Abdolvahabi A, Yun MK, Vaithiyalingam S, Tan H, Bowling J, Honnell V, Young B, Guo Y, Bajpai R, Pruett-Miller SM, Grosveld GC, Hatley M, Xu B, Fan Y, Wu G, Chen EY, Chen T, Lewis PW, Rankovic Z, Li Y, Murphy AJ, Easton J, Peng J, Chen X, Wang R, White SW, Davidoff AM, Yang J. Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. Sci Transl Med. 2022 Jul 13; 14: eabq2096.

                


                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.

                


                  Khurshid S, Montes M, Comiskey DF Jr, Shane B, Matsa E, Jung F, Brown C, Bid HK, Wang R, Houghton PJ, Roberts R, Rigo F, Chandler D. Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma. NPJ Precis Oncol. 2022 Jan 11; 6: 1.

                


                  Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Sci Adv. 2021 Nov 19; 7: eabj5405.

                


                  Wang Y, Wang F, Wang L, Qiu S, Yao Y, Yan C, Xiong X, Chen X, Ji Q, Cao J, Gao G, Li D, Zhang L, Guo Z, Wang R, Wang H, Fan G. NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells. Cell Rep. 2021 Aug 10; 36: 109516.

                


                  Kang S, Wu R, Wang R. A Simple and Robust Protocol for in vitro Differentiation of Mouse Non-pathogenic T Helper 17 Cells from CD4+ T Cells. Bio Protoc. 2021 May 20; 11: e4029.

                


                  Jia A, Wang Y, Wang Y, Li Y, Yang Q, Cao Y, He Y, Dong L, Dong Y, Hou Y, Wang R, Bi Y, Liu G. The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer. Cell Mol Immunol. 2021 Apr; 18: 1074-1076.

                


                  Lee J, Ghonime MG, Wang R, Cassady KA. The Antiviral Apparatus: STING and Oncolytic Virus Restriction. Mol Ther Oncolytics. 2019 Jun 28; 13: 7-13.

                


                  Yan J, Wang R, Horng T. mTOR Is Key to T Cell Transdifferentiation. Cell Metab. 2019 Feb 5; 29: 241-242.

                


                  Schafer JR, Salzillo TC, Chakravarti N, Kararoudi MN, Trikha P, Foltz JA, Wang R, Li S, Lee DA. Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells. J Allergy Clin Immunol. 2019 Jan; 143: 346-358.e6.

                


                  Xu X, Gnanaprakasam JNR, Sherman J, Wang R. A Metabolism Toolbox for CAR T Therapy. Front Oncol. 2019; 9: 322.

                


                  Lian G, Gnanaprakasam JR, Wang T, Wu R, Chen X, Liu L, Shen Y, Yang M, Yang J, Chen Y, Vasiliou V, Cassel TA, Green DR, Liu Y, Fan TW, Wang R. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. Elife. 2018 Sep 10; 7: 

                


                  Lu Y, Liu H, Bi Y, Yang H, Li Y, Wang J, Zhang Z, Wang Y, Li C, Jia A, Han L, Hu Y, Zhao Y, Wang R, Liu G. Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1a-dependent glycolysis. Cell Mol Immunol. 2018 Jun; 15: 618-629.

                


                  Shen Y, Sherman JW, Chen X, Wang R. Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition. J Biol Chem. 2018 Apr 6; 293: 5185-5199.

                


                  Wang T, Liu L, Chen X, Shen Y, Lian G, Shah N, Davidoff AM, Yang J, Wang R. MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent. Cell Death Dis. 2018 Feb 14; 9: 220.

                


                  Rashida Gnanaprakasam JN, Wu R, Wang R. Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity. Front Immunol. 2018; 9: 1075.

                


                  Yang J, Milasta S, Hu D, AlTahan AM, Interiano RB, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani AC, Wang R, Wang Y, Ong SS, Boyd VA, Young B, Das S, Shelat A, Wu Y, Li Z, Zheng JJ, Mishra A, Cheng Y, Qu C, Peng J, Green DR, White S, Guy RK, Chen T, Davidoff AM. Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox. Cancer Res. 2017 Sep 1; 77: 4626-4638.

                


                  Shen Y, Vignali P, Wang R. Rapid Profiling Cell Cycle by Flow Cytometry Using Concurrent Staining of DNA and Mitotic Markers. Bio Protoc. 2017 Aug 20; 7: 

                


                  Yao Q, Gutierrez DC, Hoang NH, Kim D, Wang R, Hobbs C, Zhu L. Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles. Mol Pharm. 2017 Jul 3; 14: 2378-2389.

View More Publications

Research

Lab(s)

Center for Childhood Cancer

Our lab’s fundamental interest is to understand how eukaryotic cells integrate various extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). We address our questions in patho-physiological context such as tumorigenesis and immune response. In particular, we focus on understanding the impact of the interplay between cell metabolic programs and cell signaling programs on tumorigenesis and immunity. We apply various experimental models, each of which has unique scientific features, such as mouse models of human tumor and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessible for direct intracellular injection of biological material), various primary cells from mouse (MEFs, T, B cell and macrophage), and human transformed cell lines (provide unique cellular tools to understand the potential cellular mechanisms that may mimic what happen in vivo). Publications

                  Kang S, Liu L, Wang T, Cannon M, Lin P, Fan TW, Scott DA, Wu HJ, Lane AN, Wang R. GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation. Nat Metab. 2022 Oct; 4: 1322-1335.

                


                  Zhang P, Brinton LT, Gharghabi M, Sher S, Williams K, Cannon M, Walker JS, Canfield D, Beaver L, Cempre CB, Phillips H, Chen X, Yan P, Lehman A, Scherle P, Wang M, Vaddi K, Baiocchi R, Wang R, Sampath D, Alinari L, Blachly JS, Lapalombella R. Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions. Sci Adv. 2022 Sep 16; 8: eabp9005.

                


                  Tan T, Wu C, Liu B, Pan BF, Hawke DH, Su Z, Liu S, Zhang W, Wang R, Lin SH, Kuang J. Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators. Mol Biol Cell. 2022 Aug 17;  mbcE22040118.

                


                  Singh S, Abu-Zaid A, Jin H, Fang J, Wu Q, Wang T, Feng H, Quarni W, Shao Y, Maxham L, Abdolvahabi A, Yun MK, Vaithiyalingam S, Tan H, Bowling J, Honnell V, Young B, Guo Y, Bajpai R, Pruett-Miller SM, Grosveld GC, Hatley M, Xu B, Fan Y, Wu G, Chen EY, Chen T, Lewis PW, Rankovic Z, Li Y, Murphy AJ, Easton J, Peng J, Chen X, Wang R, White SW, Davidoff AM, Yang J. Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. Sci Transl Med. 2022 Jul 13; 14: eabq2096.

                


                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.

                


                  Khurshid S, Montes M, Comiskey DF Jr, Shane B, Matsa E, Jung F, Brown C, Bid HK, Wang R, Houghton PJ, Roberts R, Rigo F, Chandler D. Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma. NPJ Precis Oncol. 2022 Jan 11; 6: 1.

                


                  Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Sci Adv. 2021 Nov 19; 7: eabj5405.

                


                  Wang Y, Wang F, Wang L, Qiu S, Yao Y, Yan C, Xiong X, Chen X, Ji Q, Cao J, Gao G, Li D, Zhang L, Guo Z, Wang R, Wang H, Fan G. NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells. Cell Rep. 2021 Aug 10; 36: 109516.

                


                  Kang S, Wu R, Wang R. A Simple and Robust Protocol for in vitro Differentiation of Mouse Non-pathogenic T Helper 17 Cells from CD4+ T Cells. Bio Protoc. 2021 May 20; 11: e4029.

                


                  Jia A, Wang Y, Wang Y, Li Y, Yang Q, Cao Y, He Y, Dong L, Dong Y, Hou Y, Wang R, Bi Y, Liu G. The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer. Cell Mol Immunol. 2021 Apr; 18: 1074-1076.

                


                  Lee J, Ghonime MG, Wang R, Cassady KA. The Antiviral Apparatus: STING and Oncolytic Virus Restriction. Mol Ther Oncolytics. 2019 Jun 28; 13: 7-13.

                


                  Yan J, Wang R, Horng T. mTOR Is Key to T Cell Transdifferentiation. Cell Metab. 2019 Feb 5; 29: 241-242.

                


                  Schafer JR, Salzillo TC, Chakravarti N, Kararoudi MN, Trikha P, Foltz JA, Wang R, Li S, Lee DA. Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells. J Allergy Clin Immunol. 2019 Jan; 143: 346-358.e6.

                


                  Xu X, Gnanaprakasam JNR, Sherman J, Wang R. A Metabolism Toolbox for CAR T Therapy. Front Oncol. 2019; 9: 322.

                


                  Lian G, Gnanaprakasam JR, Wang T, Wu R, Chen X, Liu L, Shen Y, Yang M, Yang J, Chen Y, Vasiliou V, Cassel TA, Green DR, Liu Y, Fan TW, Wang R. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. Elife. 2018 Sep 10; 7: 

                


                  Lu Y, Liu H, Bi Y, Yang H, Li Y, Wang J, Zhang Z, Wang Y, Li C, Jia A, Han L, Hu Y, Zhao Y, Wang R, Liu G. Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1a-dependent glycolysis. Cell Mol Immunol. 2018 Jun; 15: 618-629.

                


                  Shen Y, Sherman JW, Chen X, Wang R. Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition. J Biol Chem. 2018 Apr 6; 293: 5185-5199.

                


                  Wang T, Liu L, Chen X, Shen Y, Lian G, Shah N, Davidoff AM, Yang J, Wang R. MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent. Cell Death Dis. 2018 Feb 14; 9: 220.

                


                  Rashida Gnanaprakasam JN, Wu R, Wang R. Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity. Front Immunol. 2018; 9: 1075.

                


                  Yang J, Milasta S, Hu D, AlTahan AM, Interiano RB, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani AC, Wang R, Wang Y, Ong SS, Boyd VA, Young B, Das S, Shelat A, Wu Y, Li Z, Zheng JJ, Mishra A, Cheng Y, Qu C, Peng J, Green DR, White S, Guy RK, Chen T, Davidoff AM. Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox. Cancer Res. 2017 Sep 1; 77: 4626-4638.

                


                  Shen Y, Vignali P, Wang R. Rapid Profiling Cell Cycle by Flow Cytometry Using Concurrent Staining of DNA and Mitotic Markers. Bio Protoc. 2017 Aug 20; 7: 

                


                  Yao Q, Gutierrez DC, Hoang NH, Kim D, Wang R, Hobbs C, Zhu L. Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles. Mol Pharm. 2017 Jul 3; 14: 2378-2389.

View More Publications

Research

Lab(s)

Center for Childhood Cancer

Our lab’s fundamental interest is to understand how eukaryotic cells integrate various extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). We address our questions in patho-physiological context such as tumorigenesis and immune response. In particular, we focus on understanding the impact of the interplay between cell metabolic programs and cell signaling programs on tumorigenesis and immunity. We apply various experimental models, each of which has unique scientific features, such as mouse models of human tumor and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessible for direct intracellular injection of biological material), various primary cells from mouse (MEFs, T, B cell and macrophage), and human transformed cell lines (provide unique cellular tools to understand the potential cellular mechanisms that may mimic what happen in vivo). Publications

                  Kang S, Liu L, Wang T, Cannon M, Lin P, Fan TW, Scott DA, Wu HJ, Lane AN, Wang R. GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation. Nat Metab. 2022 Oct; 4: 1322-1335.

                


                  Zhang P, Brinton LT, Gharghabi M, Sher S, Williams K, Cannon M, Walker JS, Canfield D, Beaver L, Cempre CB, Phillips H, Chen X, Yan P, Lehman A, Scherle P, Wang M, Vaddi K, Baiocchi R, Wang R, Sampath D, Alinari L, Blachly JS, Lapalombella R. Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions. Sci Adv. 2022 Sep 16; 8: eabp9005.

                


                  Tan T, Wu C, Liu B, Pan BF, Hawke DH, Su Z, Liu S, Zhang W, Wang R, Lin SH, Kuang J. Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators. Mol Biol Cell. 2022 Aug 17;  mbcE22040118.

                


                  Singh S, Abu-Zaid A, Jin H, Fang J, Wu Q, Wang T, Feng H, Quarni W, Shao Y, Maxham L, Abdolvahabi A, Yun MK, Vaithiyalingam S, Tan H, Bowling J, Honnell V, Young B, Guo Y, Bajpai R, Pruett-Miller SM, Grosveld GC, Hatley M, Xu B, Fan Y, Wu G, Chen EY, Chen T, Lewis PW, Rankovic Z, Li Y, Murphy AJ, Easton J, Peng J, Chen X, Wang R, White SW, Davidoff AM, Yang J. Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. Sci Transl Med. 2022 Jul 13; 14: eabq2096.

                


                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.

                


                  Khurshid S, Montes M, Comiskey DF Jr, Shane B, Matsa E, Jung F, Brown C, Bid HK, Wang R, Houghton PJ, Roberts R, Rigo F, Chandler D. Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma. NPJ Precis Oncol. 2022 Jan 11; 6: 1.

                


                  Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Sci Adv. 2021 Nov 19; 7: eabj5405.

                


                  Wang Y, Wang F, Wang L, Qiu S, Yao Y, Yan C, Xiong X, Chen X, Ji Q, Cao J, Gao G, Li D, Zhang L, Guo Z, Wang R, Wang H, Fan G. NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells. Cell Rep. 2021 Aug 10; 36: 109516.

                


                  Kang S, Wu R, Wang R. A Simple and Robust Protocol for in vitro Differentiation of Mouse Non-pathogenic T Helper 17 Cells from CD4+ T Cells. Bio Protoc. 2021 May 20; 11: e4029.

                


                  Jia A, Wang Y, Wang Y, Li Y, Yang Q, Cao Y, He Y, Dong L, Dong Y, Hou Y, Wang R, Bi Y, Liu G. The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer. Cell Mol Immunol. 2021 Apr; 18: 1074-1076.

                


                  Lee J, Ghonime MG, Wang R, Cassady KA. The Antiviral Apparatus: STING and Oncolytic Virus Restriction. Mol Ther Oncolytics. 2019 Jun 28; 13: 7-13.

                


                  Yan J, Wang R, Horng T. mTOR Is Key to T Cell Transdifferentiation. Cell Metab. 2019 Feb 5; 29: 241-242.

                


                  Schafer JR, Salzillo TC, Chakravarti N, Kararoudi MN, Trikha P, Foltz JA, Wang R, Li S, Lee DA. Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells. J Allergy Clin Immunol. 2019 Jan; 143: 346-358.e6.

                


                  Xu X, Gnanaprakasam JNR, Sherman J, Wang R. A Metabolism Toolbox for CAR T Therapy. Front Oncol. 2019; 9: 322.

                


                  Lian G, Gnanaprakasam JR, Wang T, Wu R, Chen X, Liu L, Shen Y, Yang M, Yang J, Chen Y, Vasiliou V, Cassel TA, Green DR, Liu Y, Fan TW, Wang R. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. Elife. 2018 Sep 10; 7: 

                


                  Lu Y, Liu H, Bi Y, Yang H, Li Y, Wang J, Zhang Z, Wang Y, Li C, Jia A, Han L, Hu Y, Zhao Y, Wang R, Liu G. Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1a-dependent glycolysis. Cell Mol Immunol. 2018 Jun; 15: 618-629.

                


                  Shen Y, Sherman JW, Chen X, Wang R. Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition. J Biol Chem. 2018 Apr 6; 293: 5185-5199.

                


                  Wang T, Liu L, Chen X, Shen Y, Lian G, Shah N, Davidoff AM, Yang J, Wang R. MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent. Cell Death Dis. 2018 Feb 14; 9: 220.

                


                  Rashida Gnanaprakasam JN, Wu R, Wang R. Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity. Front Immunol. 2018; 9: 1075.

                


                  Yang J, Milasta S, Hu D, AlTahan AM, Interiano RB, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani AC, Wang R, Wang Y, Ong SS, Boyd VA, Young B, Das S, Shelat A, Wu Y, Li Z, Zheng JJ, Mishra A, Cheng Y, Qu C, Peng J, Green DR, White S, Guy RK, Chen T, Davidoff AM. Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox. Cancer Res. 2017 Sep 1; 77: 4626-4638.

                


                  Shen Y, Vignali P, Wang R. Rapid Profiling Cell Cycle by Flow Cytometry Using Concurrent Staining of DNA and Mitotic Markers. Bio Protoc. 2017 Aug 20; 7: 

                


                  Yao Q, Gutierrez DC, Hoang NH, Kim D, Wang R, Hobbs C, Zhu L. Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles. Mol Pharm. 2017 Jul 3; 14: 2378-2389.

View More Publications

Lab(s)

Center for Childhood Cancer

Our lab’s fundamental interest is to understand how eukaryotic cells integrate various extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). We address our questions in patho-physiological context such as tumorigenesis and immune response. In particular, we focus on understanding the impact of the interplay between cell metabolic programs and cell signaling programs on tumorigenesis and immunity. We apply various experimental models, each of which has unique scientific features, such as mouse models of human tumor and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessible for direct intracellular injection of biological material), various primary cells from mouse (MEFs, T, B cell and macrophage), and human transformed cell lines (provide unique cellular tools to understand the potential cellular mechanisms that may mimic what happen in vivo). Publications

                  Kang S, Liu L, Wang T, Cannon M, Lin P, Fan TW, Scott DA, Wu HJ, Lane AN, Wang R. GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation. Nat Metab. 2022 Oct; 4: 1322-1335.

                


                  Zhang P, Brinton LT, Gharghabi M, Sher S, Williams K, Cannon M, Walker JS, Canfield D, Beaver L, Cempre CB, Phillips H, Chen X, Yan P, Lehman A, Scherle P, Wang M, Vaddi K, Baiocchi R, Wang R, Sampath D, Alinari L, Blachly JS, Lapalombella R. Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions. Sci Adv. 2022 Sep 16; 8: eabp9005.

                


                  Tan T, Wu C, Liu B, Pan BF, Hawke DH, Su Z, Liu S, Zhang W, Wang R, Lin SH, Kuang J. Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators. Mol Biol Cell. 2022 Aug 17;  mbcE22040118.

                


                  Singh S, Abu-Zaid A, Jin H, Fang J, Wu Q, Wang T, Feng H, Quarni W, Shao Y, Maxham L, Abdolvahabi A, Yun MK, Vaithiyalingam S, Tan H, Bowling J, Honnell V, Young B, Guo Y, Bajpai R, Pruett-Miller SM, Grosveld GC, Hatley M, Xu B, Fan Y, Wu G, Chen EY, Chen T, Lewis PW, Rankovic Z, Li Y, Murphy AJ, Easton J, Peng J, Chen X, Wang R, White SW, Davidoff AM, Yang J. Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. Sci Transl Med. 2022 Jul 13; 14: eabq2096.

                


                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.

                


                  Khurshid S, Montes M, Comiskey DF Jr, Shane B, Matsa E, Jung F, Brown C, Bid HK, Wang R, Houghton PJ, Roberts R, Rigo F, Chandler D. Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma. NPJ Precis Oncol. 2022 Jan 11; 6: 1.

                


                  Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Sci Adv. 2021 Nov 19; 7: eabj5405.

                


                  Wang Y, Wang F, Wang L, Qiu S, Yao Y, Yan C, Xiong X, Chen X, Ji Q, Cao J, Gao G, Li D, Zhang L, Guo Z, Wang R, Wang H, Fan G. NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells. Cell Rep. 2021 Aug 10; 36: 109516.

                


                  Kang S, Wu R, Wang R. A Simple and Robust Protocol for in vitro Differentiation of Mouse Non-pathogenic T Helper 17 Cells from CD4+ T Cells. Bio Protoc. 2021 May 20; 11: e4029.

                


                  Jia A, Wang Y, Wang Y, Li Y, Yang Q, Cao Y, He Y, Dong L, Dong Y, Hou Y, Wang R, Bi Y, Liu G. The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer. Cell Mol Immunol. 2021 Apr; 18: 1074-1076.

                


                  Lee J, Ghonime MG, Wang R, Cassady KA. The Antiviral Apparatus: STING and Oncolytic Virus Restriction. Mol Ther Oncolytics. 2019 Jun 28; 13: 7-13.

                


                  Yan J, Wang R, Horng T. mTOR Is Key to T Cell Transdifferentiation. Cell Metab. 2019 Feb 5; 29: 241-242.

                


                  Schafer JR, Salzillo TC, Chakravarti N, Kararoudi MN, Trikha P, Foltz JA, Wang R, Li S, Lee DA. Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells. J Allergy Clin Immunol. 2019 Jan; 143: 346-358.e6.

                


                  Xu X, Gnanaprakasam JNR, Sherman J, Wang R. A Metabolism Toolbox for CAR T Therapy. Front Oncol. 2019; 9: 322.

                


                  Lian G, Gnanaprakasam JR, Wang T, Wu R, Chen X, Liu L, Shen Y, Yang M, Yang J, Chen Y, Vasiliou V, Cassel TA, Green DR, Liu Y, Fan TW, Wang R. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. Elife. 2018 Sep 10; 7: 

                


                  Lu Y, Liu H, Bi Y, Yang H, Li Y, Wang J, Zhang Z, Wang Y, Li C, Jia A, Han L, Hu Y, Zhao Y, Wang R, Liu G. Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1a-dependent glycolysis. Cell Mol Immunol. 2018 Jun; 15: 618-629.

                


                  Shen Y, Sherman JW, Chen X, Wang R. Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition. J Biol Chem. 2018 Apr 6; 293: 5185-5199.

                


                  Wang T, Liu L, Chen X, Shen Y, Lian G, Shah N, Davidoff AM, Yang J, Wang R. MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent. Cell Death Dis. 2018 Feb 14; 9: 220.

                


                  Rashida Gnanaprakasam JN, Wu R, Wang R. Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity. Front Immunol. 2018; 9: 1075.

                


                  Yang J, Milasta S, Hu D, AlTahan AM, Interiano RB, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani AC, Wang R, Wang Y, Ong SS, Boyd VA, Young B, Das S, Shelat A, Wu Y, Li Z, Zheng JJ, Mishra A, Cheng Y, Qu C, Peng J, Green DR, White S, Guy RK, Chen T, Davidoff AM. Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox. Cancer Res. 2017 Sep 1; 77: 4626-4638.

                


                  Shen Y, Vignali P, Wang R. Rapid Profiling Cell Cycle by Flow Cytometry Using Concurrent Staining of DNA and Mitotic Markers. Bio Protoc. 2017 Aug 20; 7: 

                


                  Yao Q, Gutierrez DC, Hoang NH, Kim D, Wang R, Hobbs C, Zhu L. Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles. Mol Pharm. 2017 Jul 3; 14: 2378-2389.

View More Publications

Lab(s)

Center for Childhood Cancer

Our lab’s fundamental interest is to understand how eukaryotic cells integrate various extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). We address our questions in patho-physiological context such as tumorigenesis and immune response. In particular, we focus on understanding the impact of the interplay between cell metabolic programs and cell signaling programs on tumorigenesis and immunity. We apply various experimental models, each of which has unique scientific features, such as mouse models of human tumor and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessible for direct intracellular injection of biological material), various primary cells from mouse (MEFs, T, B cell and macrophage), and human transformed cell lines (provide unique cellular tools to understand the potential cellular mechanisms that may mimic what happen in vivo).

Lab(s)

Center for Childhood Cancer

• Center for Childhood Cancer

                  Kang S, Liu L, Wang T, Cannon M, Lin P, Fan TW, Scott DA, Wu HJ, Lane AN, Wang R. GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation. Nat Metab. 2022 Oct; 4: 1322-1335.
  
  
  
                  Zhang P, Brinton LT, Gharghabi M, Sher S, Williams K, Cannon M, Walker JS, Canfield D, Beaver L, Cempre CB, Phillips H, Chen X, Yan P, Lehman A, Scherle P, Wang M, Vaddi K, Baiocchi R, Wang R, Sampath D, Alinari L, Blachly JS, Lapalombella R. Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions. Sci Adv. 2022 Sep 16; 8: eabp9005.
  
  
  
                  Tan T, Wu C, Liu B, Pan BF, Hawke DH, Su Z, Liu S, Zhang W, Wang R, Lin SH, Kuang J. Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators. Mol Biol Cell. 2022 Aug 17;  mbcE22040118.
  
  
  
                  Singh S, Abu-Zaid A, Jin H, Fang J, Wu Q, Wang T, Feng H, Quarni W, Shao Y, Maxham L, Abdolvahabi A, Yun MK, Vaithiyalingam S, Tan H, Bowling J, Honnell V, Young B, Guo Y, Bajpai R, Pruett-Miller SM, Grosveld GC, Hatley M, Xu B, Fan Y, Wu G, Chen EY, Chen T, Lewis PW, Rankovic Z, Li Y, Murphy AJ, Easton J, Peng J, Chen X, Wang R, White SW, Davidoff AM, Yang J. Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. Sci Transl Med. 2022 Jul 13; 14: eabq2096.
  
  
  
                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.
  
  
  
                  Khurshid S, Montes M, Comiskey DF Jr, Shane B, Matsa E, Jung F, Brown C, Bid HK, Wang R, Houghton PJ, Roberts R, Rigo F, Chandler D. Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma. NPJ Precis Oncol. 2022 Jan 11; 6: 1.
  
  
  
                  Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Sci Adv. 2021 Nov 19; 7: eabj5405.
  
  
  
                  Wang Y, Wang F, Wang L, Qiu S, Yao Y, Yan C, Xiong X, Chen X, Ji Q, Cao J, Gao G, Li D, Zhang L, Guo Z, Wang R, Wang H, Fan G. NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells. Cell Rep. 2021 Aug 10; 36: 109516.
  
  
  
                  Kang S, Wu R, Wang R. A Simple and Robust Protocol for in vitro Differentiation of Mouse Non-pathogenic T Helper 17 Cells from CD4+ T Cells. Bio Protoc. 2021 May 20; 11: e4029.
  
  
  
                  Jia A, Wang Y, Wang Y, Li Y, Yang Q, Cao Y, He Y, Dong L, Dong Y, Hou Y, Wang R, Bi Y, Liu G. The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer. Cell Mol Immunol. 2021 Apr; 18: 1074-1076.
  
  
  
                  Lee J, Ghonime MG, Wang R, Cassady KA. The Antiviral Apparatus: STING and Oncolytic Virus Restriction. Mol Ther Oncolytics. 2019 Jun 28; 13: 7-13.
  
  
  
                  Yan J, Wang R, Horng T. mTOR Is Key to T Cell Transdifferentiation. Cell Metab. 2019 Feb 5; 29: 241-242.
  
  
  
                  Schafer JR, Salzillo TC, Chakravarti N, Kararoudi MN, Trikha P, Foltz JA, Wang R, Li S, Lee DA. Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells. J Allergy Clin Immunol. 2019 Jan; 143: 346-358.e6.
  
  
  
                  Xu X, Gnanaprakasam JNR, Sherman J, Wang R. A Metabolism Toolbox for CAR T Therapy. Front Oncol. 2019; 9: 322.
  
  
  
                  Lian G, Gnanaprakasam JR, Wang T, Wu R, Chen X, Liu L, Shen Y, Yang M, Yang J, Chen Y, Vasiliou V, Cassel TA, Green DR, Liu Y, Fan TW, Wang R. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. Elife. 2018 Sep 10; 7: 
  
  
  
                  Lu Y, Liu H, Bi Y, Yang H, Li Y, Wang J, Zhang Z, Wang Y, Li C, Jia A, Han L, Hu Y, Zhao Y, Wang R, Liu G. Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1a-dependent glycolysis. Cell Mol Immunol. 2018 Jun; 15: 618-629.
  
  
  
                  Shen Y, Sherman JW, Chen X, Wang R. Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition. J Biol Chem. 2018 Apr 6; 293: 5185-5199.
  
  
  
                  Wang T, Liu L, Chen X, Shen Y, Lian G, Shah N, Davidoff AM, Yang J, Wang R. MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent. Cell Death Dis. 2018 Feb 14; 9: 220.
  
  
  
                  Rashida Gnanaprakasam JN, Wu R, Wang R. Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity. Front Immunol. 2018; 9: 1075.
  
  
  
                  Yang J, Milasta S, Hu D, AlTahan AM, Interiano RB, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani AC, Wang R, Wang Y, Ong SS, Boyd VA, Young B, Das S, Shelat A, Wu Y, Li Z, Zheng JJ, Mishra A, Cheng Y, Qu C, Peng J, Green DR, White S, Guy RK, Chen T, Davidoff AM. Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox. Cancer Res. 2017 Sep 1; 77: 4626-4638.
  
  
  
                  Shen Y, Vignali P, Wang R. Rapid Profiling Cell Cycle by Flow Cytometry Using Concurrent Staining of DNA and Mitotic Markers. Bio Protoc. 2017 Aug 20; 7: 
  
  
  
                  Yao Q, Gutierrez DC, Hoang NH, Kim D, Wang R, Hobbs C, Zhu L. Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles. Mol Pharm. 2017 Jul 3; 14: 2378-2389.
  
  

View More Publications

• Kang S, Liu L, Wang T, Cannon M, Lin P, Fan TW, Scott DA, Wu HJ, Lane AN, Wang R. GAB functions as a bioenergetic and signalling gatekeeper to control T cell inflammation. Nat Metab. 2022 Oct; 4: 1322-1335.
• Zhang P, Brinton LT, Gharghabi M, Sher S, Williams K, Cannon M, Walker JS, Canfield D, Beaver L, Cempre CB, Phillips H, Chen X, Yan P, Lehman A, Scherle P, Wang M, Vaddi K, Baiocchi R, Wang R, Sampath D, Alinari L, Blachly JS, Lapalombella R. Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions. Sci Adv. 2022 Sep 16; 8: eabp9005.
• Tan T, Wu C, Liu B, Pan BF, Hawke DH, Su Z, Liu S, Zhang W, Wang R, Lin SH, Kuang J. Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators. Mol Biol Cell. 2022 Aug 17; mbcE22040118.
• Singh S, Abu-Zaid A, Jin H, Fang J, Wu Q, Wang T, Feng H, Quarni W, Shao Y, Maxham L, Abdolvahabi A, Yun MK, Vaithiyalingam S, Tan H, Bowling J, Honnell V, Young B, Guo Y, Bajpai R, Pruett-Miller SM, Grosveld GC, Hatley M, Xu B, Fan Y, Wu G, Chen EY, Chen T, Lewis PW, Rankovic Z, Li Y, Murphy AJ, Easton J, Peng J, Chen X, Wang R, White SW, Davidoff AM, Yang J. Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. Sci Transl Med. 2022 Jul 13; 14: eabq2096.
• Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.
• Khurshid S, Montes M, Comiskey DF Jr, Shane B, Matsa E, Jung F, Brown C, Bid HK, Wang R, Houghton PJ, Roberts R, Rigo F, Chandler D. Splice-switching of the insulin receptor pre-mRNA alleviates tumorigenic hallmarks in rhabdomyosarcoma. NPJ Precis Oncol. 2022 Jan 11; 6: 1.
• Singh S, Quarni W, Goralski M, Wan S, Jin H, Van de Velde LA, Fang J, Wu Q, Abu-Zaid A, Wang T, Singh R, Craft D, Fan Y, Confer T, Johnson M, Akers WJ, Wang R, Murray PJ, Thomas PG, Nijhawan D, Davidoff AM, Yang J. Targeting the spliceosome through RBM39 degradation results in exceptional responses in high-risk neuroblastoma models. Sci Adv. 2021 Nov 19; 7: eabj5405.
• Wang Y, Wang F, Wang L, Qiu S, Yao Y, Yan C, Xiong X, Chen X, Ji Q, Cao J, Gao G, Li D, Zhang L, Guo Z, Wang R, Wang H, Fan G. NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells. Cell Rep. 2021 Aug 10; 36: 109516.
• Kang S, Wu R, Wang R. A Simple and Robust Protocol for in vitro Differentiation of Mouse Non-pathogenic T Helper 17 Cells from CD4+ T Cells. Bio Protoc. 2021 May 20; 11: e4029.
• Jia A, Wang Y, Wang Y, Li Y, Yang Q, Cao Y, He Y, Dong L, Dong Y, Hou Y, Wang R, Bi Y, Liu G. The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer. Cell Mol Immunol. 2021 Apr; 18: 1074-1076.
• Lee J, Ghonime MG, Wang R, Cassady KA. The Antiviral Apparatus: STING and Oncolytic Virus Restriction. Mol Ther Oncolytics. 2019 Jun 28; 13: 7-13.
• Yan J, Wang R, Horng T. mTOR Is Key to T Cell Transdifferentiation. Cell Metab. 2019 Feb 5; 29: 241-242.
• Schafer JR, Salzillo TC, Chakravarti N, Kararoudi MN, Trikha P, Foltz JA, Wang R, Li S, Lee DA. Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells. J Allergy Clin Immunol. 2019 Jan; 143: 346-358.e6.
• Xu X, Gnanaprakasam JNR, Sherman J, Wang R. A Metabolism Toolbox for CAR T Therapy. Front Oncol. 2019; 9: 322.
• Lian G, Gnanaprakasam JR, Wang T, Wu R, Chen X, Liu L, Shen Y, Yang M, Yang J, Chen Y, Vasiliou V, Cassel TA, Green DR, Liu Y, Fan TW, Wang R. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation. Elife. 2018 Sep 10; 7:
• Lu Y, Liu H, Bi Y, Yang H, Li Y, Wang J, Zhang Z, Wang Y, Li C, Jia A, Han L, Hu Y, Zhao Y, Wang R, Liu G. Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1a-dependent glycolysis. Cell Mol Immunol. 2018 Jun; 15: 618-629.
• Shen Y, Sherman JW, Chen X, Wang R. Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition. J Biol Chem. 2018 Apr 6; 293: 5185-5199.
• Wang T, Liu L, Chen X, Shen Y, Lian G, Shah N, Davidoff AM, Yang J, Wang R. MYCN drives glutaminolysis in neuroblastoma and confers sensitivity to an ROS augmenting agent. Cell Death Dis. 2018 Feb 14; 9: 220.
• Rashida Gnanaprakasam JN, Wu R, Wang R. Metabolic Reprogramming in Modulating T Cell Reactive Oxygen Species Generation and Antioxidant Capacity. Front Immunol. 2018; 9: 1075.
• Yang J, Milasta S, Hu D, AlTahan AM, Interiano RB, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani AC, Wang R, Wang Y, Ong SS, Boyd VA, Young B, Das S, Shelat A, Wu Y, Li Z, Zheng JJ, Mishra A, Cheng Y, Qu C, Peng J, Green DR, White S, Guy RK, Chen T, Davidoff AM. Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox. Cancer Res. 2017 Sep 1; 77: 4626-4638.
• Shen Y, Vignali P, Wang R. Rapid Profiling Cell Cycle by Flow Cytometry Using Concurrent Staining of DNA and Mitotic Markers. Bio Protoc. 2017 Aug 20; 7:
• Yao Q, Gutierrez DC, Hoang NH, Kim D, Wang R, Hobbs C, Zhu L. Efficient Codelivery of Paclitaxel and Curcumin by Novel Bottlebrush Copolymer-based Micelles. Mol Pharm. 2017 Jul 3; 14: 2378-2389.

Professional Experience

1996 - 1996 Nanjing Medical University, Teacher

Professional Experience

1996 - 1996 Nanjing Medical University, Teacher

Professional Experience

1996 - 1996 Nanjing Medical University, Teacher

1996 - 1996 Nanjing Medical University, Teacher

1996 - 1996 Nanjing Medical University, Teacher

Contact Information

Center for Childhood Cancer

Call us at: (614)355-2980

Fax us at: (614)722-5895

                    700 Children's Drive Room WA5016Columbus, Ohio 43205 (map)

Contact Information

Center for Childhood Cancer

Call us at: (614)355-2980

Fax us at: (614)722-5895

                    700 Children's Drive Room WA5016Columbus, Ohio 43205 (map)

Contact Information

Center for Childhood Cancer

Call us at: (614)355-2980

Fax us at: (614)722-5895

                    700 Children's Drive Room WA5016Columbus, Ohio 43205 (map)

Center for Childhood Cancer

Call us at: (614)355-2980

Fax us at: (614)722-5895

                    700 Children's Drive Room WA5016Columbus, Ohio 43205 (map)

Call us at: (614)355-2980

Fax us at: (614)722-5895

                    700 Children's Drive Room WA5016Columbus, Ohio 43205 (map)

Call us at: (614)355-2980

Fax us at: (614)722-5895

                    700 Children's Drive Room WA5016Columbus, Ohio 43205 (map)

• Call us at:
• (614)355-2980
• Fax us at:
• (614)722-5895
• 700 Children’s Drive Room WA5016Columbus, Ohio 43205 (map)