Contact Information

Call us at: (614) 355-6710

Email Rodney D. Britt, PhD

Center for Perinatal Research575 Children’s CrossroadColumbus, OH 43215 (map)

Learn more about Rodney D. Britt

Research

Lab(s)

Center for Perinatal Research

Although an effective in suppressing inflammation, corticosteroids are largely ineffective in preventing the pathological and functional changes in airway disease. Consequentially, asthmatic patients insensitive to corticosteroids have difficulty managing symptoms and experience greater disease burden. Dr. Britt’s lab studies how airway inflammation affects corticosteroid insensitivity in airway disease, while developing novel strategies to improve corticosteroid sensitivity and alleviate asthma.  Publications

                  Sheikh S, Britt RD Jr, Ryan-Wenger NA, Khan AQ, Lewis BW, Gushue C, Ozuna H, Jaganathan D, McCoy K, Kopp BT. Impact of Elexacaftor-Tezacaftor-Ivacaftor on Bacterial Colonization and Inflammatory Responses in Cystic Fibrosis. Pediatr Pulmonol. 2022 Nov 29;  

                


                  Guerau-de-Arellano M, Britt RD Jr. Sterols in asthma. Trends Immunol. 2022 Aug 27;  

                


                  Jackson D, Walum J, Banerjee P, Lewis BW, Prakash YS, Sathish V, Xu Z, Britt RD Jr. Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle. Respir Res. 2022 May 16; 23: 126.

                


                  Lewis BW, Amici SA, Kim HY, Shalosky EM, Khan AQ, Walum J, Gowdy KM, Englert JA, Porter NA, Grayson MH, Britt RD Jr, Guerau-de-Arellano M. PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation. J Immunol. 2022 Apr 1; 208: 1525-1533.

                


                  Lewis BW, Ford ML, Khan AQ, Walum J, Britt RD Jr. Chronic Allergen Challenge Induces Corticosteroid Insensitivity With Persistent Airway Remodeling and Type 2 Inflammation. Front Pharmacol. 2022; 13: 855247.

                


                  Lewis BW, Jackson D, Amici SA, Walum J, Guessas M, Guessas S, Coneglio E, Boda AV, Guerau-de-Arellano M, Grayson MH, Britt RD Jr. Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2021 Dec 1; 321: L1194-L1205.

                


                  Sheikh SI, Ryan-Wenger NA, Pitts J, Britt R Jr, Paul G, Ulrich L. Impact of guideline adherence and race on asthma control in children. World J Pediatr. 2021 Oct; 17: 500-507.

                


                  Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 

                


                  Banerjee P, Balraj P, Ambhore NS, Wicher SA, Britt RD Jr, Pabelick CM, Prakash YS, Sathish V. Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma. Sci Rep. 2021 Jul 13; 11: 14386.

                


                  Roesler AM, Wicher SA, Ravix J, Britt RD Jr, Manlove L, Teske JJ, Cummings K, Thompson MA, Farver C, MacFarlane P, Pabelick CM, Prakash YS. Calcium sensing receptor in developing human airway smooth muscle. J Cell Physiol. 2019 Aug; 234: 14187-14197.

                


                  You K, Parikh P, Khandalavala K, Wicher S, Manlove LJ, Yang B, Roesler AM, Roos B, Teske JJ, Britt RD Jr, Pabelick CM, Prakash YS. Moderate hyperoxia induces senescence in developing human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 14;  

                


                  Drake LY, Squillace D, Iijima K, Kobayashi T, Uchida M, Kephart GM, Britt R, O'Brien DR, Kita H. Early Life Represents a Vulnerable Time Window for IL-33-Induced Peripheral Lung Pathology. J Immunol. 2019 Aug 30;  

                


                  Vogel ER, Manlove LJ, Kuipers I, Thompson MA, Fang YH, Freeman MR, Britt RD Jr, Faksh A, Yang B, Prakash YS, Pabelick CM. Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model. Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1; 317: L99-L108.

                


                  Parikh P, Wicher S, Khandalavala K, Pabelick CM, Britt RD Jr, Prakash YS. Cellular senescence in the lung across the age spectrum. Am J Physiol Lung Cell Mol Physiol. 2019 May 1; 316: L826-L842.

                


                  Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  

                


                  Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.

                


                  Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.

                


                  Parikh P, Britt RD Jr, Manlove LJ, Wicher SA, Roesler A, Ravix J, Teske J, Thompson MA, Sieck GC, Kirkland JL, LeBrasseur N, Tschumperlin DJ, Pabelick CM, Prakash YS. Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2018 Dec 3;  

                


                  Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD Jr, Prakash YS, Bhattacharya M. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 Nov 2; 3: 

                


                  Britt RD Jr, Thompson MA, Wicher SA, Manlove LJ, Roesler A, Fang YH, Roos C, Smith L, Miller JD, Pabelick CM, Prakash YS. Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma. FASEB J. 2018 Oct 23;  fj201801002R.

View More Publications

Biography

Rodney D. Britt Jr, PhD, is a Principal Investigator at Nationwide Children’s Hospital and an Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Britt earned his BS in Chemistry from North Carolina A&T State University and PhD in Biomedical Sciences from The Ohio State University. He completed his postdoctoral training at Mayo Clinic in Rochester, MN. His research training centered on understanding mechanisms in neonatal and pediatric airway diseases, most notably asthma and bronchopulmonary dysplasia. Children with airway disease experience significant airflow obstruction, airway hyperresponsiveness, and chronic inflammation. Furthermore, development of airway disease as a child increases the risk having a chronic airway as an adult. Dr. Britt’s lab aims to advance understanding of mechanisms related to neonatal and pediatric airway disease, with emphasis on how airway inflammation affects airway structure and function in asthma. 

Academic and Clinical Areas

Center for Perinatal Research

Principal Investigator

Primary Department

Center for Perinatal Research

Awards, Honors & Organizations

Member, American Heart Association, 2015 - Present Member, American Physiological Society, 2014 - Present Member, American Thoracic Society, 2009 - Present

Education

Date of Appointment at Nationwide Children’s Hospital: 06/01/2018

Postdoctoral Training

Mayo Clinic

Date Completed: 06/04/2018

Graduate School

The Ohio State University

Date Completed: 12/16/2012

Undergraduate School

North Carolina A&T State University

Date Completed: 05/15/2006

Professional Experience

2018 - Present Nationwide Children’s Hospital, Principal Investigator2017 - 2018 Mayo Clinic, Associate Consultant I2012 - 2017 Mayo Clinic, Postdoctoral Fellow

Research Funding

National Institutes of Health R01 HL155095 Airway Structural Cells and Corticosteroid Resistance in Asthma, Principal Investigator The goal of this proposal is to investigate how Th1 cytokines, notably IFNγ, mediate corticosteroid resistance in severe allergic airway inflammation and primary human airway smooth muscle cells. These studies will integrate RNA-, ATAC-, and ChIP-seq analyses to assess changes in chromatin accessibility that may affect corticosteroid sensitivity. National Institutes of Health R00 HL131682 Enhancing Corticosteroid Sensitivity in Neonatal and Pediatric Lung Diseases, Principal Investigator The goal of this proposal is to provide the training necessary for transition to an independent research career. Studies will examine how inflammation disrupts glucocorticoid receptor signaling and assess potential therapeutic approaches to restore corticosteroid sensitivity in pediatric asthma.

Contact Information

Center for Perinatal Research

Call us at: (614) 355-6710

Email Rodney D Britt

                    575 Children's CrossroadColumbus, OH 43215 (map)

Contact Information

Call us at: (614) 355-6710

Email Rodney D. Britt, PhD

Center for Perinatal Research575 Children’s CrossroadColumbus, OH 43215 (map)

Learn more about Rodney D. Britt

Research

Lab(s)

Center for Perinatal Research

Although an effective in suppressing inflammation, corticosteroids are largely ineffective in preventing the pathological and functional changes in airway disease. Consequentially, asthmatic patients insensitive to corticosteroids have difficulty managing symptoms and experience greater disease burden. Dr. Britt’s lab studies how airway inflammation affects corticosteroid insensitivity in airway disease, while developing novel strategies to improve corticosteroid sensitivity and alleviate asthma.  Publications

                  Sheikh S, Britt RD Jr, Ryan-Wenger NA, Khan AQ, Lewis BW, Gushue C, Ozuna H, Jaganathan D, McCoy K, Kopp BT. Impact of Elexacaftor-Tezacaftor-Ivacaftor on Bacterial Colonization and Inflammatory Responses in Cystic Fibrosis. Pediatr Pulmonol. 2022 Nov 29;  

                


                  Guerau-de-Arellano M, Britt RD Jr. Sterols in asthma. Trends Immunol. 2022 Aug 27;  

                


                  Jackson D, Walum J, Banerjee P, Lewis BW, Prakash YS, Sathish V, Xu Z, Britt RD Jr. Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle. Respir Res. 2022 May 16; 23: 126.

                


                  Lewis BW, Amici SA, Kim HY, Shalosky EM, Khan AQ, Walum J, Gowdy KM, Englert JA, Porter NA, Grayson MH, Britt RD Jr, Guerau-de-Arellano M. PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation. J Immunol. 2022 Apr 1; 208: 1525-1533.

                


                  Lewis BW, Ford ML, Khan AQ, Walum J, Britt RD Jr. Chronic Allergen Challenge Induces Corticosteroid Insensitivity With Persistent Airway Remodeling and Type 2 Inflammation. Front Pharmacol. 2022; 13: 855247.

                


                  Lewis BW, Jackson D, Amici SA, Walum J, Guessas M, Guessas S, Coneglio E, Boda AV, Guerau-de-Arellano M, Grayson MH, Britt RD Jr. Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2021 Dec 1; 321: L1194-L1205.

                


                  Sheikh SI, Ryan-Wenger NA, Pitts J, Britt R Jr, Paul G, Ulrich L. Impact of guideline adherence and race on asthma control in children. World J Pediatr. 2021 Oct; 17: 500-507.

                


                  Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 

                


                  Banerjee P, Balraj P, Ambhore NS, Wicher SA, Britt RD Jr, Pabelick CM, Prakash YS, Sathish V. Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma. Sci Rep. 2021 Jul 13; 11: 14386.

                


                  Roesler AM, Wicher SA, Ravix J, Britt RD Jr, Manlove L, Teske JJ, Cummings K, Thompson MA, Farver C, MacFarlane P, Pabelick CM, Prakash YS. Calcium sensing receptor in developing human airway smooth muscle. J Cell Physiol. 2019 Aug; 234: 14187-14197.

                


                  You K, Parikh P, Khandalavala K, Wicher S, Manlove LJ, Yang B, Roesler AM, Roos B, Teske JJ, Britt RD Jr, Pabelick CM, Prakash YS. Moderate hyperoxia induces senescence in developing human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 14;  

                


                  Drake LY, Squillace D, Iijima K, Kobayashi T, Uchida M, Kephart GM, Britt R, O'Brien DR, Kita H. Early Life Represents a Vulnerable Time Window for IL-33-Induced Peripheral Lung Pathology. J Immunol. 2019 Aug 30;  

                


                  Vogel ER, Manlove LJ, Kuipers I, Thompson MA, Fang YH, Freeman MR, Britt RD Jr, Faksh A, Yang B, Prakash YS, Pabelick CM. Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model. Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1; 317: L99-L108.

                


                  Parikh P, Wicher S, Khandalavala K, Pabelick CM, Britt RD Jr, Prakash YS. Cellular senescence in the lung across the age spectrum. Am J Physiol Lung Cell Mol Physiol. 2019 May 1; 316: L826-L842.

                


                  Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  

                


                  Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.

                


                  Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.

                


                  Parikh P, Britt RD Jr, Manlove LJ, Wicher SA, Roesler A, Ravix J, Teske J, Thompson MA, Sieck GC, Kirkland JL, LeBrasseur N, Tschumperlin DJ, Pabelick CM, Prakash YS. Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2018 Dec 3;  

                


                  Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD Jr, Prakash YS, Bhattacharya M. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 Nov 2; 3: 

                


                  Britt RD Jr, Thompson MA, Wicher SA, Manlove LJ, Roesler A, Fang YH, Roos C, Smith L, Miller JD, Pabelick CM, Prakash YS. Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma. FASEB J. 2018 Oct 23;  fj201801002R.

View More Publications

Biography

Rodney D. Britt Jr, PhD, is a Principal Investigator at Nationwide Children’s Hospital and an Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Britt earned his BS in Chemistry from North Carolina A&T State University and PhD in Biomedical Sciences from The Ohio State University. He completed his postdoctoral training at Mayo Clinic in Rochester, MN. His research training centered on understanding mechanisms in neonatal and pediatric airway diseases, most notably asthma and bronchopulmonary dysplasia. Children with airway disease experience significant airflow obstruction, airway hyperresponsiveness, and chronic inflammation. Furthermore, development of airway disease as a child increases the risk having a chronic airway as an adult. Dr. Britt’s lab aims to advance understanding of mechanisms related to neonatal and pediatric airway disease, with emphasis on how airway inflammation affects airway structure and function in asthma. 

Academic and Clinical Areas

Center for Perinatal Research

Principal Investigator

Primary Department

Center for Perinatal Research

Awards, Honors & Organizations

Member, American Heart Association, 2015 - Present Member, American Physiological Society, 2014 - Present Member, American Thoracic Society, 2009 - Present

Education

Date of Appointment at Nationwide Children’s Hospital: 06/01/2018

Postdoctoral Training

Mayo Clinic

Date Completed: 06/04/2018

Graduate School

The Ohio State University

Date Completed: 12/16/2012

Undergraduate School

North Carolina A&T State University

Date Completed: 05/15/2006

Professional Experience

2018 - Present Nationwide Children’s Hospital, Principal Investigator2017 - 2018 Mayo Clinic, Associate Consultant I2012 - 2017 Mayo Clinic, Postdoctoral Fellow

Research Funding

National Institutes of Health R01 HL155095 Airway Structural Cells and Corticosteroid Resistance in Asthma, Principal Investigator The goal of this proposal is to investigate how Th1 cytokines, notably IFNγ, mediate corticosteroid resistance in severe allergic airway inflammation and primary human airway smooth muscle cells. These studies will integrate RNA-, ATAC-, and ChIP-seq analyses to assess changes in chromatin accessibility that may affect corticosteroid sensitivity. National Institutes of Health R00 HL131682 Enhancing Corticosteroid Sensitivity in Neonatal and Pediatric Lung Diseases, Principal Investigator The goal of this proposal is to provide the training necessary for transition to an independent research career. Studies will examine how inflammation disrupts glucocorticoid receptor signaling and assess potential therapeutic approaches to restore corticosteroid sensitivity in pediatric asthma.

Contact Information

Center for Perinatal Research

Call us at: (614) 355-6710

Email Rodney D Britt

                    575 Children's CrossroadColumbus, OH 43215 (map)

Contact Information

Call us at: (614) 355-6710

Email Rodney D. Britt, PhD

Center for Perinatal Research575 Children’s CrossroadColumbus, OH 43215 (map)

Learn more about Rodney D. Britt

Contact Information

  • Call us at:
  • (614) 355-6710
  • Email Rodney D. Britt, PhD
  • Center for Perinatal Research575 Children’s CrossroadColumbus, OH 43215 (map)

Learn more about Rodney D. Britt

Research

Lab(s)

Center for Perinatal Research

Although an effective in suppressing inflammation, corticosteroids are largely ineffective in preventing the pathological and functional changes in airway disease. Consequentially, asthmatic patients insensitive to corticosteroids have difficulty managing symptoms and experience greater disease burden. Dr. Britt’s lab studies how airway inflammation affects corticosteroid insensitivity in airway disease, while developing novel strategies to improve corticosteroid sensitivity and alleviate asthma.  Publications

                  Sheikh S, Britt RD Jr, Ryan-Wenger NA, Khan AQ, Lewis BW, Gushue C, Ozuna H, Jaganathan D, McCoy K, Kopp BT. Impact of Elexacaftor-Tezacaftor-Ivacaftor on Bacterial Colonization and Inflammatory Responses in Cystic Fibrosis. Pediatr Pulmonol. 2022 Nov 29;  

                


                  Guerau-de-Arellano M, Britt RD Jr. Sterols in asthma. Trends Immunol. 2022 Aug 27;  

                


                  Jackson D, Walum J, Banerjee P, Lewis BW, Prakash YS, Sathish V, Xu Z, Britt RD Jr. Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle. Respir Res. 2022 May 16; 23: 126.

                


                  Lewis BW, Amici SA, Kim HY, Shalosky EM, Khan AQ, Walum J, Gowdy KM, Englert JA, Porter NA, Grayson MH, Britt RD Jr, Guerau-de-Arellano M. PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation. J Immunol. 2022 Apr 1; 208: 1525-1533.

                


                  Lewis BW, Ford ML, Khan AQ, Walum J, Britt RD Jr. Chronic Allergen Challenge Induces Corticosteroid Insensitivity With Persistent Airway Remodeling and Type 2 Inflammation. Front Pharmacol. 2022; 13: 855247.

                


                  Lewis BW, Jackson D, Amici SA, Walum J, Guessas M, Guessas S, Coneglio E, Boda AV, Guerau-de-Arellano M, Grayson MH, Britt RD Jr. Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2021 Dec 1; 321: L1194-L1205.

                


                  Sheikh SI, Ryan-Wenger NA, Pitts J, Britt R Jr, Paul G, Ulrich L. Impact of guideline adherence and race on asthma control in children. World J Pediatr. 2021 Oct; 17: 500-507.

                


                  Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 

                


                  Banerjee P, Balraj P, Ambhore NS, Wicher SA, Britt RD Jr, Pabelick CM, Prakash YS, Sathish V. Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma. Sci Rep. 2021 Jul 13; 11: 14386.

                


                  Roesler AM, Wicher SA, Ravix J, Britt RD Jr, Manlove L, Teske JJ, Cummings K, Thompson MA, Farver C, MacFarlane P, Pabelick CM, Prakash YS. Calcium sensing receptor in developing human airway smooth muscle. J Cell Physiol. 2019 Aug; 234: 14187-14197.

                


                  You K, Parikh P, Khandalavala K, Wicher S, Manlove LJ, Yang B, Roesler AM, Roos B, Teske JJ, Britt RD Jr, Pabelick CM, Prakash YS. Moderate hyperoxia induces senescence in developing human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 14;  

                


                  Drake LY, Squillace D, Iijima K, Kobayashi T, Uchida M, Kephart GM, Britt R, O'Brien DR, Kita H. Early Life Represents a Vulnerable Time Window for IL-33-Induced Peripheral Lung Pathology. J Immunol. 2019 Aug 30;  

                


                  Vogel ER, Manlove LJ, Kuipers I, Thompson MA, Fang YH, Freeman MR, Britt RD Jr, Faksh A, Yang B, Prakash YS, Pabelick CM. Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model. Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1; 317: L99-L108.

                


                  Parikh P, Wicher S, Khandalavala K, Pabelick CM, Britt RD Jr, Prakash YS. Cellular senescence in the lung across the age spectrum. Am J Physiol Lung Cell Mol Physiol. 2019 May 1; 316: L826-L842.

                


                  Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  

                


                  Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.

                


                  Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.

                


                  Parikh P, Britt RD Jr, Manlove LJ, Wicher SA, Roesler A, Ravix J, Teske J, Thompson MA, Sieck GC, Kirkland JL, LeBrasseur N, Tschumperlin DJ, Pabelick CM, Prakash YS. Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2018 Dec 3;  

                


                  Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD Jr, Prakash YS, Bhattacharya M. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 Nov 2; 3: 

                


                  Britt RD Jr, Thompson MA, Wicher SA, Manlove LJ, Roesler A, Fang YH, Roos C, Smith L, Miller JD, Pabelick CM, Prakash YS. Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma. FASEB J. 2018 Oct 23;  fj201801002R.

View More Publications

Research

Lab(s)

Center for Perinatal Research

Although an effective in suppressing inflammation, corticosteroids are largely ineffective in preventing the pathological and functional changes in airway disease. Consequentially, asthmatic patients insensitive to corticosteroids have difficulty managing symptoms and experience greater disease burden. Dr. Britt’s lab studies how airway inflammation affects corticosteroid insensitivity in airway disease, while developing novel strategies to improve corticosteroid sensitivity and alleviate asthma.  Publications

                  Sheikh S, Britt RD Jr, Ryan-Wenger NA, Khan AQ, Lewis BW, Gushue C, Ozuna H, Jaganathan D, McCoy K, Kopp BT. Impact of Elexacaftor-Tezacaftor-Ivacaftor on Bacterial Colonization and Inflammatory Responses in Cystic Fibrosis. Pediatr Pulmonol. 2022 Nov 29;  

                


                  Guerau-de-Arellano M, Britt RD Jr. Sterols in asthma. Trends Immunol. 2022 Aug 27;  

                


                  Jackson D, Walum J, Banerjee P, Lewis BW, Prakash YS, Sathish V, Xu Z, Britt RD Jr. Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle. Respir Res. 2022 May 16; 23: 126.

                


                  Lewis BW, Amici SA, Kim HY, Shalosky EM, Khan AQ, Walum J, Gowdy KM, Englert JA, Porter NA, Grayson MH, Britt RD Jr, Guerau-de-Arellano M. PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation. J Immunol. 2022 Apr 1; 208: 1525-1533.

                


                  Lewis BW, Ford ML, Khan AQ, Walum J, Britt RD Jr. Chronic Allergen Challenge Induces Corticosteroid Insensitivity With Persistent Airway Remodeling and Type 2 Inflammation. Front Pharmacol. 2022; 13: 855247.

                


                  Lewis BW, Jackson D, Amici SA, Walum J, Guessas M, Guessas S, Coneglio E, Boda AV, Guerau-de-Arellano M, Grayson MH, Britt RD Jr. Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2021 Dec 1; 321: L1194-L1205.

                


                  Sheikh SI, Ryan-Wenger NA, Pitts J, Britt R Jr, Paul G, Ulrich L. Impact of guideline adherence and race on asthma control in children. World J Pediatr. 2021 Oct; 17: 500-507.

                


                  Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 

                


                  Banerjee P, Balraj P, Ambhore NS, Wicher SA, Britt RD Jr, Pabelick CM, Prakash YS, Sathish V. Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma. Sci Rep. 2021 Jul 13; 11: 14386.

                


                  Roesler AM, Wicher SA, Ravix J, Britt RD Jr, Manlove L, Teske JJ, Cummings K, Thompson MA, Farver C, MacFarlane P, Pabelick CM, Prakash YS. Calcium sensing receptor in developing human airway smooth muscle. J Cell Physiol. 2019 Aug; 234: 14187-14197.

                


                  You K, Parikh P, Khandalavala K, Wicher S, Manlove LJ, Yang B, Roesler AM, Roos B, Teske JJ, Britt RD Jr, Pabelick CM, Prakash YS. Moderate hyperoxia induces senescence in developing human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 14;  

                


                  Drake LY, Squillace D, Iijima K, Kobayashi T, Uchida M, Kephart GM, Britt R, O'Brien DR, Kita H. Early Life Represents a Vulnerable Time Window for IL-33-Induced Peripheral Lung Pathology. J Immunol. 2019 Aug 30;  

                


                  Vogel ER, Manlove LJ, Kuipers I, Thompson MA, Fang YH, Freeman MR, Britt RD Jr, Faksh A, Yang B, Prakash YS, Pabelick CM. Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model. Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1; 317: L99-L108.

                


                  Parikh P, Wicher S, Khandalavala K, Pabelick CM, Britt RD Jr, Prakash YS. Cellular senescence in the lung across the age spectrum. Am J Physiol Lung Cell Mol Physiol. 2019 May 1; 316: L826-L842.

                


                  Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  

                


                  Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.

                


                  Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.

                


                  Parikh P, Britt RD Jr, Manlove LJ, Wicher SA, Roesler A, Ravix J, Teske J, Thompson MA, Sieck GC, Kirkland JL, LeBrasseur N, Tschumperlin DJ, Pabelick CM, Prakash YS. Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2018 Dec 3;  

                


                  Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD Jr, Prakash YS, Bhattacharya M. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 Nov 2; 3: 

                


                  Britt RD Jr, Thompson MA, Wicher SA, Manlove LJ, Roesler A, Fang YH, Roos C, Smith L, Miller JD, Pabelick CM, Prakash YS. Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma. FASEB J. 2018 Oct 23;  fj201801002R.

View More Publications

Research

Lab(s)

Center for Perinatal Research

Although an effective in suppressing inflammation, corticosteroids are largely ineffective in preventing the pathological and functional changes in airway disease. Consequentially, asthmatic patients insensitive to corticosteroids have difficulty managing symptoms and experience greater disease burden. Dr. Britt’s lab studies how airway inflammation affects corticosteroid insensitivity in airway disease, while developing novel strategies to improve corticosteroid sensitivity and alleviate asthma.  Publications

                  Sheikh S, Britt RD Jr, Ryan-Wenger NA, Khan AQ, Lewis BW, Gushue C, Ozuna H, Jaganathan D, McCoy K, Kopp BT. Impact of Elexacaftor-Tezacaftor-Ivacaftor on Bacterial Colonization and Inflammatory Responses in Cystic Fibrosis. Pediatr Pulmonol. 2022 Nov 29;  

                


                  Guerau-de-Arellano M, Britt RD Jr. Sterols in asthma. Trends Immunol. 2022 Aug 27;  

                


                  Jackson D, Walum J, Banerjee P, Lewis BW, Prakash YS, Sathish V, Xu Z, Britt RD Jr. Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle. Respir Res. 2022 May 16; 23: 126.

                


                  Lewis BW, Amici SA, Kim HY, Shalosky EM, Khan AQ, Walum J, Gowdy KM, Englert JA, Porter NA, Grayson MH, Britt RD Jr, Guerau-de-Arellano M. PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation. J Immunol. 2022 Apr 1; 208: 1525-1533.

                


                  Lewis BW, Ford ML, Khan AQ, Walum J, Britt RD Jr. Chronic Allergen Challenge Induces Corticosteroid Insensitivity With Persistent Airway Remodeling and Type 2 Inflammation. Front Pharmacol. 2022; 13: 855247.

                


                  Lewis BW, Jackson D, Amici SA, Walum J, Guessas M, Guessas S, Coneglio E, Boda AV, Guerau-de-Arellano M, Grayson MH, Britt RD Jr. Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2021 Dec 1; 321: L1194-L1205.

                


                  Sheikh SI, Ryan-Wenger NA, Pitts J, Britt R Jr, Paul G, Ulrich L. Impact of guideline adherence and race on asthma control in children. World J Pediatr. 2021 Oct; 17: 500-507.

                


                  Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 

                


                  Banerjee P, Balraj P, Ambhore NS, Wicher SA, Britt RD Jr, Pabelick CM, Prakash YS, Sathish V. Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma. Sci Rep. 2021 Jul 13; 11: 14386.

                


                  Roesler AM, Wicher SA, Ravix J, Britt RD Jr, Manlove L, Teske JJ, Cummings K, Thompson MA, Farver C, MacFarlane P, Pabelick CM, Prakash YS. Calcium sensing receptor in developing human airway smooth muscle. J Cell Physiol. 2019 Aug; 234: 14187-14197.

                


                  You K, Parikh P, Khandalavala K, Wicher S, Manlove LJ, Yang B, Roesler AM, Roos B, Teske JJ, Britt RD Jr, Pabelick CM, Prakash YS. Moderate hyperoxia induces senescence in developing human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 14;  

                


                  Drake LY, Squillace D, Iijima K, Kobayashi T, Uchida M, Kephart GM, Britt R, O'Brien DR, Kita H. Early Life Represents a Vulnerable Time Window for IL-33-Induced Peripheral Lung Pathology. J Immunol. 2019 Aug 30;  

                


                  Vogel ER, Manlove LJ, Kuipers I, Thompson MA, Fang YH, Freeman MR, Britt RD Jr, Faksh A, Yang B, Prakash YS, Pabelick CM. Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model. Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1; 317: L99-L108.

                


                  Parikh P, Wicher S, Khandalavala K, Pabelick CM, Britt RD Jr, Prakash YS. Cellular senescence in the lung across the age spectrum. Am J Physiol Lung Cell Mol Physiol. 2019 May 1; 316: L826-L842.

                


                  Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  

                


                  Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.

                


                  Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.

                


                  Parikh P, Britt RD Jr, Manlove LJ, Wicher SA, Roesler A, Ravix J, Teske J, Thompson MA, Sieck GC, Kirkland JL, LeBrasseur N, Tschumperlin DJ, Pabelick CM, Prakash YS. Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2018 Dec 3;  

                


                  Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD Jr, Prakash YS, Bhattacharya M. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 Nov 2; 3: 

                


                  Britt RD Jr, Thompson MA, Wicher SA, Manlove LJ, Roesler A, Fang YH, Roos C, Smith L, Miller JD, Pabelick CM, Prakash YS. Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma. FASEB J. 2018 Oct 23;  fj201801002R.

View More Publications

Lab(s)

Center for Perinatal Research

Although an effective in suppressing inflammation, corticosteroids are largely ineffective in preventing the pathological and functional changes in airway disease. Consequentially, asthmatic patients insensitive to corticosteroids have difficulty managing symptoms and experience greater disease burden. Dr. Britt’s lab studies how airway inflammation affects corticosteroid insensitivity in airway disease, while developing novel strategies to improve corticosteroid sensitivity and alleviate asthma.  Publications

                  Sheikh S, Britt RD Jr, Ryan-Wenger NA, Khan AQ, Lewis BW, Gushue C, Ozuna H, Jaganathan D, McCoy K, Kopp BT. Impact of Elexacaftor-Tezacaftor-Ivacaftor on Bacterial Colonization and Inflammatory Responses in Cystic Fibrosis. Pediatr Pulmonol. 2022 Nov 29;  

                


                  Guerau-de-Arellano M, Britt RD Jr. Sterols in asthma. Trends Immunol. 2022 Aug 27;  

                


                  Jackson D, Walum J, Banerjee P, Lewis BW, Prakash YS, Sathish V, Xu Z, Britt RD Jr. Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle. Respir Res. 2022 May 16; 23: 126.

                


                  Lewis BW, Amici SA, Kim HY, Shalosky EM, Khan AQ, Walum J, Gowdy KM, Englert JA, Porter NA, Grayson MH, Britt RD Jr, Guerau-de-Arellano M. PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation. J Immunol. 2022 Apr 1; 208: 1525-1533.

                


                  Lewis BW, Ford ML, Khan AQ, Walum J, Britt RD Jr. Chronic Allergen Challenge Induces Corticosteroid Insensitivity With Persistent Airway Remodeling and Type 2 Inflammation. Front Pharmacol. 2022; 13: 855247.

                


                  Lewis BW, Jackson D, Amici SA, Walum J, Guessas M, Guessas S, Coneglio E, Boda AV, Guerau-de-Arellano M, Grayson MH, Britt RD Jr. Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2021 Dec 1; 321: L1194-L1205.

                


                  Sheikh SI, Ryan-Wenger NA, Pitts J, Britt R Jr, Paul G, Ulrich L. Impact of guideline adherence and race on asthma control in children. World J Pediatr. 2021 Oct; 17: 500-507.

                


                  Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 

                


                  Banerjee P, Balraj P, Ambhore NS, Wicher SA, Britt RD Jr, Pabelick CM, Prakash YS, Sathish V. Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma. Sci Rep. 2021 Jul 13; 11: 14386.

                


                  Roesler AM, Wicher SA, Ravix J, Britt RD Jr, Manlove L, Teske JJ, Cummings K, Thompson MA, Farver C, MacFarlane P, Pabelick CM, Prakash YS. Calcium sensing receptor in developing human airway smooth muscle. J Cell Physiol. 2019 Aug; 234: 14187-14197.

                


                  You K, Parikh P, Khandalavala K, Wicher S, Manlove LJ, Yang B, Roesler AM, Roos B, Teske JJ, Britt RD Jr, Pabelick CM, Prakash YS. Moderate hyperoxia induces senescence in developing human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 14;  

                


                  Drake LY, Squillace D, Iijima K, Kobayashi T, Uchida M, Kephart GM, Britt R, O'Brien DR, Kita H. Early Life Represents a Vulnerable Time Window for IL-33-Induced Peripheral Lung Pathology. J Immunol. 2019 Aug 30;  

                


                  Vogel ER, Manlove LJ, Kuipers I, Thompson MA, Fang YH, Freeman MR, Britt RD Jr, Faksh A, Yang B, Prakash YS, Pabelick CM. Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model. Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1; 317: L99-L108.

                


                  Parikh P, Wicher S, Khandalavala K, Pabelick CM, Britt RD Jr, Prakash YS. Cellular senescence in the lung across the age spectrum. Am J Physiol Lung Cell Mol Physiol. 2019 May 1; 316: L826-L842.

                


                  Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  

                


                  Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.

                


                  Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.

                


                  Parikh P, Britt RD Jr, Manlove LJ, Wicher SA, Roesler A, Ravix J, Teske J, Thompson MA, Sieck GC, Kirkland JL, LeBrasseur N, Tschumperlin DJ, Pabelick CM, Prakash YS. Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2018 Dec 3;  

                


                  Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD Jr, Prakash YS, Bhattacharya M. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 Nov 2; 3: 

                


                  Britt RD Jr, Thompson MA, Wicher SA, Manlove LJ, Roesler A, Fang YH, Roos C, Smith L, Miller JD, Pabelick CM, Prakash YS. Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma. FASEB J. 2018 Oct 23;  fj201801002R.

View More Publications

Lab(s)

Center for Perinatal Research

Although an effective in suppressing inflammation, corticosteroids are largely ineffective in preventing the pathological and functional changes in airway disease. Consequentially, asthmatic patients insensitive to corticosteroids have difficulty managing symptoms and experience greater disease burden. Dr. Britt’s lab studies how airway inflammation affects corticosteroid insensitivity in airway disease, while developing novel strategies to improve corticosteroid sensitivity and alleviate asthma. 

Lab(s)

Center for Perinatal Research

  • Center for Perinatal Research

                    Sheikh S, Britt RD Jr, Ryan-Wenger NA, Khan AQ, Lewis BW, Gushue C, Ozuna H, Jaganathan D, McCoy K, Kopp BT. Impact of Elexacaftor-Tezacaftor-Ivacaftor on Bacterial Colonization and Inflammatory Responses in Cystic Fibrosis. Pediatr Pulmonol. 2022 Nov 29;  



                Guerau-de-Arellano M, Britt RD Jr. Sterols in asthma. Trends Immunol. 2022 Aug 27;  



                Jackson D, Walum J, Banerjee P, Lewis BW, Prakash YS, Sathish V, Xu Z, Britt RD Jr. Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle. Respir Res. 2022 May 16; 23: 126.



                Lewis BW, Amici SA, Kim HY, Shalosky EM, Khan AQ, Walum J, Gowdy KM, Englert JA, Porter NA, Grayson MH, Britt RD Jr, Guerau-de-Arellano M. PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation. J Immunol. 2022 Apr 1; 208: 1525-1533.



                Lewis BW, Ford ML, Khan AQ, Walum J, Britt RD Jr. Chronic Allergen Challenge Induces Corticosteroid Insensitivity With Persistent Airway Remodeling and Type 2 Inflammation. Front Pharmacol. 2022; 13: 855247.



                Lewis BW, Jackson D, Amici SA, Walum J, Guessas M, Guessas S, Coneglio E, Boda AV, Guerau-de-Arellano M, Grayson MH, Britt RD Jr. Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2021 Dec 1; 321: L1194-L1205.



                Sheikh SI, Ryan-Wenger NA, Pitts J, Britt R Jr, Paul G, Ulrich L. Impact of guideline adherence and race on asthma control in children. World J Pediatr. 2021 Oct; 17: 500-507.



                Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 



                Banerjee P, Balraj P, Ambhore NS, Wicher SA, Britt RD Jr, Pabelick CM, Prakash YS, Sathish V. Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma. Sci Rep. 2021 Jul 13; 11: 14386.



                Roesler AM, Wicher SA, Ravix J, Britt RD Jr, Manlove L, Teske JJ, Cummings K, Thompson MA, Farver C, MacFarlane P, Pabelick CM, Prakash YS. Calcium sensing receptor in developing human airway smooth muscle. J Cell Physiol. 2019 Aug; 234: 14187-14197.



                You K, Parikh P, Khandalavala K, Wicher S, Manlove LJ, Yang B, Roesler AM, Roos B, Teske JJ, Britt RD Jr, Pabelick CM, Prakash YS. Moderate hyperoxia induces senescence in developing human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 14;  



                Drake LY, Squillace D, Iijima K, Kobayashi T, Uchida M, Kephart GM, Britt R, O'Brien DR, Kita H. Early Life Represents a Vulnerable Time Window for IL-33-Induced Peripheral Lung Pathology. J Immunol. 2019 Aug 30;  



                Vogel ER, Manlove LJ, Kuipers I, Thompson MA, Fang YH, Freeman MR, Britt RD Jr, Faksh A, Yang B, Prakash YS, Pabelick CM. Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model. Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1; 317: L99-L108.



                Parikh P, Wicher S, Khandalavala K, Pabelick CM, Britt RD Jr, Prakash YS. Cellular senescence in the lung across the age spectrum. Am J Physiol Lung Cell Mol Physiol. 2019 May 1; 316: L826-L842.



                Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  



                Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.



                Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.



                Parikh P, Britt RD Jr, Manlove LJ, Wicher SA, Roesler A, Ravix J, Teske J, Thompson MA, Sieck GC, Kirkland JL, LeBrasseur N, Tschumperlin DJ, Pabelick CM, Prakash YS. Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2018 Dec 3;  



                Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD Jr, Prakash YS, Bhattacharya M. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 Nov 2; 3: 



                Britt RD Jr, Thompson MA, Wicher SA, Manlove LJ, Roesler A, Fang YH, Roos C, Smith L, Miller JD, Pabelick CM, Prakash YS. Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma. FASEB J. 2018 Oct 23;  fj201801002R.

View More Publications

  • Sheikh S, Britt RD Jr, Ryan-Wenger NA, Khan AQ, Lewis BW, Gushue C, Ozuna H, Jaganathan D, McCoy K, Kopp BT. Impact of Elexacaftor-Tezacaftor-Ivacaftor on Bacterial Colonization and Inflammatory Responses in Cystic Fibrosis. Pediatr Pulmonol. 2022 Nov 29;
  • Guerau-de-Arellano M, Britt RD Jr. Sterols in asthma. Trends Immunol. 2022 Aug 27;
  • Jackson D, Walum J, Banerjee P, Lewis BW, Prakash YS, Sathish V, Xu Z, Britt RD Jr. Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle. Respir Res. 2022 May 16; 23: 126.
  • Lewis BW, Amici SA, Kim HY, Shalosky EM, Khan AQ, Walum J, Gowdy KM, Englert JA, Porter NA, Grayson MH, Britt RD Jr, Guerau-de-Arellano M. PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation. J Immunol. 2022 Apr 1; 208: 1525-1533.
  • Lewis BW, Ford ML, Khan AQ, Walum J, Britt RD Jr. Chronic Allergen Challenge Induces Corticosteroid Insensitivity With Persistent Airway Remodeling and Type 2 Inflammation. Front Pharmacol. 2022; 13: 855247.
  • Lewis BW, Jackson D, Amici SA, Walum J, Guessas M, Guessas S, Coneglio E, Boda AV, Guerau-de-Arellano M, Grayson MH, Britt RD Jr. Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2021 Dec 1; 321: L1194-L1205.
  • Sheikh SI, Ryan-Wenger NA, Pitts J, Britt R Jr, Paul G, Ulrich L. Impact of guideline adherence and race on asthma control in children. World J Pediatr. 2021 Oct; 17: 500-507.
  • Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10:
  • Banerjee P, Balraj P, Ambhore NS, Wicher SA, Britt RD Jr, Pabelick CM, Prakash YS, Sathish V. Network and co-expression analysis of airway smooth muscle cell transcriptome delineates potential gene signatures in asthma. Sci Rep. 2021 Jul 13; 11: 14386.
  • Roesler AM, Wicher SA, Ravix J, Britt RD Jr, Manlove L, Teske JJ, Cummings K, Thompson MA, Farver C, MacFarlane P, Pabelick CM, Prakash YS. Calcium sensing receptor in developing human airway smooth muscle. J Cell Physiol. 2019 Aug; 234: 14187-14197.
  • You K, Parikh P, Khandalavala K, Wicher S, Manlove LJ, Yang B, Roesler AM, Roos B, Teske JJ, Britt RD Jr, Pabelick CM, Prakash YS. Moderate hyperoxia induces senescence in developing human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2019 Aug 14;
  • Drake LY, Squillace D, Iijima K, Kobayashi T, Uchida M, Kephart GM, Britt R, O’Brien DR, Kita H. Early Life Represents a Vulnerable Time Window for IL-33-Induced Peripheral Lung Pathology. J Immunol. 2019 Aug 30;
  • Vogel ER, Manlove LJ, Kuipers I, Thompson MA, Fang YH, Freeman MR, Britt RD Jr, Faksh A, Yang B, Prakash YS, Pabelick CM. Caveolin-1 scaffolding domain peptide prevents hyperoxia-induced airway remodeling in a neonatal mouse model. Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1; 317: L99-L108.
  • Parikh P, Wicher S, Khandalavala K, Pabelick CM, Britt RD Jr, Prakash YS. Cellular senescence in the lung across the age spectrum. Am J Physiol Lung Cell Mol Physiol. 2019 May 1; 316: L826-L842.
  • Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;
  • Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.
  • Britt RD Jr, Thompson MA, Sasse S, Pabelick CM, Gerber AN, Prakash YS. Th1 cytokines TNF-a and IFN-? promote corticosteroid resistance in developing human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1; 316: L71-L81.
  • Parikh P, Britt RD Jr, Manlove LJ, Wicher SA, Roesler A, Ravix J, Teske J, Thompson MA, Sieck GC, Kirkland JL, LeBrasseur N, Tschumperlin DJ, Pabelick CM, Prakash YS. Hyperoxia-Induced Cellular Senescence in Fetal Airway Smooth Muscle Cells. Am J Respir Cell Mol Biol. 2018 Dec 3;
  • Fong V, Hsu A, Wu E, Looney AP, Ganesan P, Ren X, Sheppard D, Wicher SA, Thompson MA, Britt RD Jr, Prakash YS, Bhattacharya M. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight. 2018 Nov 2; 3:
  • Britt RD Jr, Thompson MA, Wicher SA, Manlove LJ, Roesler A, Fang YH, Roos C, Smith L, Miller JD, Pabelick CM, Prakash YS. Smooth muscle brain-derived neurotrophic factor contributes to airway hyperreactivity in a mouse model of allergic asthma. FASEB J. 2018 Oct 23; fj201801002R.

Biography

Rodney D. Britt Jr, PhD, is a Principal Investigator at Nationwide Children’s Hospital and an Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Britt earned his BS in Chemistry from North Carolina A&T State University and PhD in Biomedical Sciences from The Ohio State University. He completed his postdoctoral training at Mayo Clinic in Rochester, MN. His research training centered on understanding mechanisms in neonatal and pediatric airway diseases, most notably asthma and bronchopulmonary dysplasia. Children with airway disease experience significant airflow obstruction, airway hyperresponsiveness, and chronic inflammation. Furthermore, development of airway disease as a child increases the risk having a chronic airway as an adult. Dr. Britt’s lab aims to advance understanding of mechanisms related to neonatal and pediatric airway disease, with emphasis on how airway inflammation affects airway structure and function in asthma. 

Biography

Rodney D. Britt Jr, PhD, is a Principal Investigator at Nationwide Children’s Hospital and an Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Britt earned his BS in Chemistry from North Carolina A&T State University and PhD in Biomedical Sciences from The Ohio State University. He completed his postdoctoral training at Mayo Clinic in Rochester, MN. His research training centered on understanding mechanisms in neonatal and pediatric airway diseases, most notably asthma and bronchopulmonary dysplasia. Children with airway disease experience significant airflow obstruction, airway hyperresponsiveness, and chronic inflammation. Furthermore, development of airway disease as a child increases the risk having a chronic airway as an adult. Dr. Britt’s lab aims to advance understanding of mechanisms related to neonatal and pediatric airway disease, with emphasis on how airway inflammation affects airway structure and function in asthma. 

Biography

Rodney D. Britt Jr, PhD, is a Principal Investigator at Nationwide Children’s Hospital and an Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Britt earned his BS in Chemistry from North Carolina A&T State University and PhD in Biomedical Sciences from The Ohio State University. He completed his postdoctoral training at Mayo Clinic in Rochester, MN. His research training centered on understanding mechanisms in neonatal and pediatric airway diseases, most notably asthma and bronchopulmonary dysplasia. Children with airway disease experience significant airflow obstruction, airway hyperresponsiveness, and chronic inflammation. Furthermore, development of airway disease as a child increases the risk having a chronic airway as an adult. Dr. Britt’s lab aims to advance understanding of mechanisms related to neonatal and pediatric airway disease, with emphasis on how airway inflammation affects airway structure and function in asthma. 

Rodney D. Britt Jr, PhD, is a Principal Investigator at Nationwide Children’s Hospital and an Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Britt earned his BS in Chemistry from North Carolina A&T State University and PhD in Biomedical Sciences from The Ohio State University. He completed his postdoctoral training at Mayo Clinic in Rochester, MN. His research training centered on understanding mechanisms in neonatal and pediatric airway diseases, most notably asthma and bronchopulmonary dysplasia. Children with airway disease experience significant airflow obstruction, airway hyperresponsiveness, and chronic inflammation. Furthermore, development of airway disease as a child increases the risk having a chronic airway as an adult. Dr. Britt’s lab aims to advance understanding of mechanisms related to neonatal and pediatric airway disease, with emphasis on how airway inflammation affects airway structure and function in asthma. 

Rodney D. Britt Jr, PhD, is a Principal Investigator at Nationwide Children’s Hospital and an Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Britt earned his BS in Chemistry from North Carolina A&T State University and PhD in Biomedical Sciences from The Ohio State University. He completed his postdoctoral training at Mayo Clinic in Rochester, MN. His research training centered on understanding mechanisms in neonatal and pediatric airway diseases, most notably asthma and bronchopulmonary dysplasia.

Children with airway disease experience significant airflow obstruction, airway hyperresponsiveness, and chronic inflammation. Furthermore, development of airway disease as a child increases the risk having a chronic airway as an adult. Dr. Britt’s lab aims to advance understanding of mechanisms related to neonatal and pediatric airway disease, with emphasis on how airway inflammation affects airway structure and function in asthma. 

Academic and Clinical Areas

Center for Perinatal Research

Principal Investigator

Primary Department

Center for Perinatal Research

Academic and Clinical Areas

Center for Perinatal Research

Principal Investigator

Primary Department

Center for Perinatal Research

Academic and Clinical Areas

Center for Perinatal Research

Principal Investigator

Primary Department

Center for Perinatal Research

Center for Perinatal Research

Principal Investigator

Primary Department

Center for Perinatal Research

  • Center for Perinatal Research
  • Principal Investigator
  • Primary Department
  • Center for Perinatal Research

Awards, Honors & Organizations

Member, American Heart Association, 2015 - Present Member, American Physiological Society, 2014 - Present Member, American Thoracic Society, 2009 - Present

Awards, Honors & Organizations

Member, American Heart Association, 2015 - Present Member, American Physiological Society, 2014 - Present Member, American Thoracic Society, 2009 - Present

Awards, Honors & Organizations

Member, American Heart Association, 2015 - Present Member, American Physiological Society, 2014 - Present Member, American Thoracic Society, 2009 - Present

Member, American Heart Association, 2015 - Present Member, American Physiological Society, 2014 - Present Member, American Thoracic Society, 2009 - Present

  • Member, American Heart Association, 2015 - Present
  • Member, American Physiological Society, 2014 - Present
  • Member, American Thoracic Society, 2009 - Present

Education

Date of Appointment at Nationwide Children’s Hospital: 06/01/2018

Postdoctoral Training

Mayo Clinic

Date Completed: 06/04/2018

Graduate School

The Ohio State University

Date Completed: 12/16/2012

Undergraduate School

North Carolina A&T State University

Date Completed: 05/15/2006

Education

Date of Appointment at Nationwide Children’s Hospital: 06/01/2018

Postdoctoral Training

Mayo Clinic

Date Completed: 06/04/2018

Graduate School

The Ohio State University

Date Completed: 12/16/2012

Undergraduate School

North Carolina A&T State University

Date Completed: 05/15/2006

Education

Date of Appointment at Nationwide Children’s Hospital: 06/01/2018

Postdoctoral Training

Mayo Clinic

Date Completed: 06/04/2018

Graduate School

The Ohio State University

Date Completed: 12/16/2012

Undergraduate School

North Carolina A&T State University

Date Completed: 05/15/2006

Date of Appointment at Nationwide Children’s Hospital: 06/01/2018

Postdoctoral Training

Mayo Clinic

Date Completed: 06/04/2018

Graduate School

The Ohio State University

Date Completed: 12/16/2012

Undergraduate School

North Carolina A&T State University

Date Completed: 05/15/2006

Date of Appointment at Nationwide Children’s Hospital: 06/01/2018

Postdoctoral Training

Mayo Clinic

Date Completed: 06/04/2018

Graduate School

The Ohio State University

Date Completed: 12/16/2012

Undergraduate School

North Carolina A&T State University

Date Completed: 05/15/2006

Professional Experience

2018 - Present Nationwide Children’s Hospital, Principal Investigator2017 - 2018 Mayo Clinic, Associate Consultant I2012 - 2017 Mayo Clinic, Postdoctoral Fellow

Professional Experience

2018 - Present Nationwide Children’s Hospital, Principal Investigator2017 - 2018 Mayo Clinic, Associate Consultant I2012 - 2017 Mayo Clinic, Postdoctoral Fellow

Professional Experience

2018 - Present Nationwide Children’s Hospital, Principal Investigator2017 - 2018 Mayo Clinic, Associate Consultant I2012 - 2017 Mayo Clinic, Postdoctoral Fellow

2018 - Present Nationwide Children’s Hospital, Principal Investigator2017 - 2018 Mayo Clinic, Associate Consultant I2012 - 2017 Mayo Clinic, Postdoctoral Fellow

2018 - Present Nationwide Children’s Hospital, Principal Investigator

Research Funding

National Institutes of Health R01 HL155095 Airway Structural Cells and Corticosteroid Resistance in Asthma, Principal Investigator The goal of this proposal is to investigate how Th1 cytokines, notably IFNγ, mediate corticosteroid resistance in severe allergic airway inflammation and primary human airway smooth muscle cells. These studies will integrate RNA-, ATAC-, and ChIP-seq analyses to assess changes in chromatin accessibility that may affect corticosteroid sensitivity. National Institutes of Health R00 HL131682 Enhancing Corticosteroid Sensitivity in Neonatal and Pediatric Lung Diseases, Principal Investigator The goal of this proposal is to provide the training necessary for transition to an independent research career. Studies will examine how inflammation disrupts glucocorticoid receptor signaling and assess potential therapeutic approaches to restore corticosteroid sensitivity in pediatric asthma.

Research Funding

National Institutes of Health R01 HL155095 Airway Structural Cells and Corticosteroid Resistance in Asthma, Principal Investigator The goal of this proposal is to investigate how Th1 cytokines, notably IFNγ, mediate corticosteroid resistance in severe allergic airway inflammation and primary human airway smooth muscle cells. These studies will integrate RNA-, ATAC-, and ChIP-seq analyses to assess changes in chromatin accessibility that may affect corticosteroid sensitivity. National Institutes of Health R00 HL131682 Enhancing Corticosteroid Sensitivity in Neonatal and Pediatric Lung Diseases, Principal Investigator The goal of this proposal is to provide the training necessary for transition to an independent research career. Studies will examine how inflammation disrupts glucocorticoid receptor signaling and assess potential therapeutic approaches to restore corticosteroid sensitivity in pediatric asthma.

Research Funding

National Institutes of Health R01 HL155095 Airway Structural Cells and Corticosteroid Resistance in Asthma, Principal Investigator The goal of this proposal is to investigate how Th1 cytokines, notably IFNγ, mediate corticosteroid resistance in severe allergic airway inflammation and primary human airway smooth muscle cells. These studies will integrate RNA-, ATAC-, and ChIP-seq analyses to assess changes in chromatin accessibility that may affect corticosteroid sensitivity. National Institutes of Health R00 HL131682 Enhancing Corticosteroid Sensitivity in Neonatal and Pediatric Lung Diseases, Principal Investigator The goal of this proposal is to provide the training necessary for transition to an independent research career. Studies will examine how inflammation disrupts glucocorticoid receptor signaling and assess potential therapeutic approaches to restore corticosteroid sensitivity in pediatric asthma.

National Institutes of Health R01 HL155095 Airway Structural Cells and Corticosteroid Resistance in Asthma, Principal Investigator The goal of this proposal is to investigate how Th1 cytokines, notably IFNγ, mediate corticosteroid resistance in severe allergic airway inflammation and primary human airway smooth muscle cells. These studies will integrate RNA-, ATAC-, and ChIP-seq analyses to assess changes in chromatin accessibility that may affect corticosteroid sensitivity. National Institutes of Health R00 HL131682 Enhancing Corticosteroid Sensitivity in Neonatal and Pediatric Lung Diseases, Principal Investigator The goal of this proposal is to provide the training necessary for transition to an independent research career. Studies will examine how inflammation disrupts glucocorticoid receptor signaling and assess potential therapeutic approaches to restore corticosteroid sensitivity in pediatric asthma.

Airway Structural Cells and Corticosteroid Resistance in Asthma, Principal Investigator

The goal of this proposal is to investigate how Th1 cytokines, notably IFNγ, mediate corticosteroid resistance in severe allergic airway inflammation and primary human airway smooth muscle cells. These studies will integrate RNA-, ATAC-, and ChIP-seq analyses to assess changes in chromatin accessibility that may affect corticosteroid sensitivity.

Enhancing Corticosteroid Sensitivity in Neonatal and Pediatric Lung Diseases, Principal Investigator

The goal of this proposal is to provide the training necessary for transition to an independent research career. Studies will examine how inflammation disrupts glucocorticoid receptor signaling and assess potential therapeutic approaches to restore corticosteroid sensitivity in pediatric asthma.

Contact Information

Center for Perinatal Research

Call us at: (614) 355-6710

Email Rodney D Britt

                    575 Children's CrossroadColumbus, OH 43215 (map)

Contact Information

Center for Perinatal Research

Call us at: (614) 355-6710

Email Rodney D Britt

                    575 Children's CrossroadColumbus, OH 43215 (map)

Contact Information

Center for Perinatal Research

Call us at: (614) 355-6710

Email Rodney D Britt

                    575 Children's CrossroadColumbus, OH 43215 (map)

Center for Perinatal Research

Call us at: (614) 355-6710

Email Rodney D Britt

                    575 Children's CrossroadColumbus, OH 43215 (map)

Call us at: (614) 355-6710

Email Rodney D Britt

                    575 Children's CrossroadColumbus, OH 43215 (map)

Call us at: (614) 355-6710

Email Rodney D Britt

                    575 Children's CrossroadColumbus, OH 43215 (map)
  • Call us at:
  • (614) 355-6710
  • Email Rodney D Britt
  • 575 Children’s CrossroadColumbus, OH 43215 (map)