Contact Information

Call us at: (614) 355-5936

Institute for Genomic Medicine700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Prajwal Rajappa

Biography

Prajwal Rajappa, MD, MS, is a physician-scientist and principal investigator for the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at IGM with a focus on precision medicine and immunotherapy for patients diagnosed with Central Nervous System (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics and Neurological Surgery and member of the Translational Therapeutics Research Program at The James Comprehensive Cancer Center of The Ohio State University College of Medicine. After obtaining his MD, Dr. Rajappa completed a unique fellowship and post-doctoral training program in the Department of Neurological Surgery of Weill Cornell Medical Center and Memorial Sloan-Kettering Cancer Center. As a fellow in Neurological Surgery, his training provided him the opportunity to observe the adult and pediatric neurosurgical management of brain and spinal tumors. Dr. Rajappa performed extensive basic science post-doctoral training with a specific focus on brain tumor immunology and the glioma microenvironment and his work has been published in the Journal of Clinical Investigation, Cancer Research, and Clinical Cancer Research. During his time at Weill Cornell Medicine, Dr. Rajappa was also actively involved in a large scale clinically annotated biorepository study with the Children’s Oncology Group (COG). To further his goal of developing targeted clinical trials for brain tumor patients, Dr. Rajappa obtained a Master’s of Science Degree in Clinical and Translational Investigation from Cornell University based on his experience coordinating a precision medicine program for patients with pediatric brain tumors at Weill Cornell Medicine.

Academic and Clinical Areas

Rajappa Lab

Principal Investigator

Primary Department

Institute for Genomic Medicine

Awards, Honors & Organizations

Pediatric Precision Oncology Award, Alex’s Lemonade Stand Foundation, 2018 Member, Society for Neuro-Oncology, 2019 - Present Member, American Association for Cancer Research, 2019 - Present

Research

Interests

Adult and Pediatric Brain Tumors Genomic Medicine Next-Generation Sequencing (NGS) Tumor Immunology Tumor Microenvironment

Dr. Rajappa is a physician-scientist and principal investigator in the Steve and Cindy Rasmussen Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at the IGM with a focus on precision medicine and immunotherapy for patients diagnosed with central nervous system (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics at The Ohio State University College of Medicine and faculty member of the Translational Therapeutics Research Program at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. Publications

                  Kalathoor S, Rajendran S, Canella A, Raval R, Cripe TP, Mardis ER, Rajappa P. Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors. J Neuroimmunol. 2022 Dec 5; 374: 578009.

                


                  Rajappa P, Eng KW, Bareja R, Bander ED, Yuan M, Dua A, Bhanu Maachani U, Snuderl M, Pan H, Zhang T, Tosi U, Ivasyk I, Souweidane MM, Elemento O, Sboner A, Greenfield JP, Pisapia DJ. Utility of multimodality molecular profiling for pediatric patients with central nervous system tumors. Neurooncol Adv. 2022 Jan-Dec; 4: vdac031.

                


                  Aggarwal P, Luo W, Pehlivan KC, Hoang H, Rajappa P, Cripe TP, Cassady KA, Lee DA, Cairo MS. Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations. Front Immunol. 2022; 13: 1038096.

                


                  Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse J, Pisapia DJ, Chan TA, Lyden DC, Bromberg JF, Greenfield JP. Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells. Clin Cancer Res. 2017 Jun 15; 23: 3109-3119.

                


                  Huang Y, Rajappa P, Hu W, Hoffman C, Cisse B, Kim JH, Gorge E, Yanowitch R, Cope W, Vartanian E, Xu R, Zhang T, Pisapia D, Xiang J, Huse J, Matei I, Peinado H, Bromberg J, Holland E, Ding BS, Rafii S, Lyden D, Greenfield J. A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. J Clin Invest. 2017 May 1; 127: 1826-1838.

                


                  Kossatz S, Carney B, Schweitzer M, Carlucci G, Miloushev VZ, Maachani UB, Rajappa P, Keshari KR, Pisapia D, Weber WA, Souweidane MM, Reiner T. Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models. Cancer Res. 2017 Apr 15; 77: 2112-2123.

                


                  Pisapia DJ, Salvatore S, Pauli C, Hissong E, Eng K, Prandi D, Sailer VW, Robinson BD, Park K, Cyrta J, Tagawa ST, Kossai M, Fontugne J, Kim R, Sigaras A, Rao R, Pancirer D, Faltas B, Bareja R, Molina AM, Nanus DM, Rajappa P, Souweidane MM, Greenfield J, Emde AK, Robine N, Elemento O, Sboner A, Demichelis F, Beltran H, Rubin MA, Mosquera JM. Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models. JCO Precis Oncol. 2017; 2017:

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 09/30/2019

Postdoctoral Training

Weill Cornell Medical College of Cornell University

Date Completed: 07/31/2019

Graduate School

Weill Cornell Medical College of Cornell University

Date Completed: 05/31/2019

Medical School

St. George’s University School of Medicine

Date Completed: 12/31/2010

Clinical Interests

Clinical Trials Immuno-Oncology Immunotherapy Intra-arterial Drug Delivery Low Grade Gliomas Precision Medicine

Contact Information

Institute for Genomic Medicine

Call us at: (614) 355-5936

                    700 Children's DriveColumbus, OH 43205 (map)

Connect with Prajwal Rajappa

Connect on ResearchGate

Connect on Twitter

Contact Information

Call us at: (614) 355-5936

Institute for Genomic Medicine700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Prajwal Rajappa

Biography

Prajwal Rajappa, MD, MS, is a physician-scientist and principal investigator for the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at IGM with a focus on precision medicine and immunotherapy for patients diagnosed with Central Nervous System (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics and Neurological Surgery and member of the Translational Therapeutics Research Program at The James Comprehensive Cancer Center of The Ohio State University College of Medicine. After obtaining his MD, Dr. Rajappa completed a unique fellowship and post-doctoral training program in the Department of Neurological Surgery of Weill Cornell Medical Center and Memorial Sloan-Kettering Cancer Center. As a fellow in Neurological Surgery, his training provided him the opportunity to observe the adult and pediatric neurosurgical management of brain and spinal tumors. Dr. Rajappa performed extensive basic science post-doctoral training with a specific focus on brain tumor immunology and the glioma microenvironment and his work has been published in the Journal of Clinical Investigation, Cancer Research, and Clinical Cancer Research. During his time at Weill Cornell Medicine, Dr. Rajappa was also actively involved in a large scale clinically annotated biorepository study with the Children’s Oncology Group (COG). To further his goal of developing targeted clinical trials for brain tumor patients, Dr. Rajappa obtained a Master’s of Science Degree in Clinical and Translational Investigation from Cornell University based on his experience coordinating a precision medicine program for patients with pediatric brain tumors at Weill Cornell Medicine.

Academic and Clinical Areas

Rajappa Lab

Principal Investigator

Primary Department

Institute for Genomic Medicine

Awards, Honors & Organizations

Pediatric Precision Oncology Award, Alex’s Lemonade Stand Foundation, 2018 Member, Society for Neuro-Oncology, 2019 - Present Member, American Association for Cancer Research, 2019 - Present

Research

Interests

Adult and Pediatric Brain Tumors Genomic Medicine Next-Generation Sequencing (NGS) Tumor Immunology Tumor Microenvironment

Dr. Rajappa is a physician-scientist and principal investigator in the Steve and Cindy Rasmussen Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at the IGM with a focus on precision medicine and immunotherapy for patients diagnosed with central nervous system (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics at The Ohio State University College of Medicine and faculty member of the Translational Therapeutics Research Program at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. Publications

                  Kalathoor S, Rajendran S, Canella A, Raval R, Cripe TP, Mardis ER, Rajappa P. Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors. J Neuroimmunol. 2022 Dec 5; 374: 578009.

                


                  Rajappa P, Eng KW, Bareja R, Bander ED, Yuan M, Dua A, Bhanu Maachani U, Snuderl M, Pan H, Zhang T, Tosi U, Ivasyk I, Souweidane MM, Elemento O, Sboner A, Greenfield JP, Pisapia DJ. Utility of multimodality molecular profiling for pediatric patients with central nervous system tumors. Neurooncol Adv. 2022 Jan-Dec; 4: vdac031.

                


                  Aggarwal P, Luo W, Pehlivan KC, Hoang H, Rajappa P, Cripe TP, Cassady KA, Lee DA, Cairo MS. Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations. Front Immunol. 2022; 13: 1038096.

                


                  Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse J, Pisapia DJ, Chan TA, Lyden DC, Bromberg JF, Greenfield JP. Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells. Clin Cancer Res. 2017 Jun 15; 23: 3109-3119.

                


                  Huang Y, Rajappa P, Hu W, Hoffman C, Cisse B, Kim JH, Gorge E, Yanowitch R, Cope W, Vartanian E, Xu R, Zhang T, Pisapia D, Xiang J, Huse J, Matei I, Peinado H, Bromberg J, Holland E, Ding BS, Rafii S, Lyden D, Greenfield J. A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. J Clin Invest. 2017 May 1; 127: 1826-1838.

                


                  Kossatz S, Carney B, Schweitzer M, Carlucci G, Miloushev VZ, Maachani UB, Rajappa P, Keshari KR, Pisapia D, Weber WA, Souweidane MM, Reiner T. Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models. Cancer Res. 2017 Apr 15; 77: 2112-2123.

                


                  Pisapia DJ, Salvatore S, Pauli C, Hissong E, Eng K, Prandi D, Sailer VW, Robinson BD, Park K, Cyrta J, Tagawa ST, Kossai M, Fontugne J, Kim R, Sigaras A, Rao R, Pancirer D, Faltas B, Bareja R, Molina AM, Nanus DM, Rajappa P, Souweidane MM, Greenfield J, Emde AK, Robine N, Elemento O, Sboner A, Demichelis F, Beltran H, Rubin MA, Mosquera JM. Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models. JCO Precis Oncol. 2017; 2017:

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 09/30/2019

Postdoctoral Training

Weill Cornell Medical College of Cornell University

Date Completed: 07/31/2019

Graduate School

Weill Cornell Medical College of Cornell University

Date Completed: 05/31/2019

Medical School

St. George’s University School of Medicine

Date Completed: 12/31/2010

Clinical Interests

Clinical Trials Immuno-Oncology Immunotherapy Intra-arterial Drug Delivery Low Grade Gliomas Precision Medicine

Contact Information

Institute for Genomic Medicine

Call us at: (614) 355-5936

                    700 Children's DriveColumbus, OH 43205 (map)

Connect with Prajwal Rajappa

Connect on ResearchGate

Connect on Twitter

Contact Information

Call us at: (614) 355-5936

Institute for Genomic Medicine700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Prajwal Rajappa

Contact Information

  • Call us at:
  • (614) 355-5936
  • Institute for Genomic Medicine700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Prajwal Rajappa

Biography

Prajwal Rajappa, MD, MS, is a physician-scientist and principal investigator for the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at IGM with a focus on precision medicine and immunotherapy for patients diagnosed with Central Nervous System (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics and Neurological Surgery and member of the Translational Therapeutics Research Program at The James Comprehensive Cancer Center of The Ohio State University College of Medicine. After obtaining his MD, Dr. Rajappa completed a unique fellowship and post-doctoral training program in the Department of Neurological Surgery of Weill Cornell Medical Center and Memorial Sloan-Kettering Cancer Center. As a fellow in Neurological Surgery, his training provided him the opportunity to observe the adult and pediatric neurosurgical management of brain and spinal tumors. Dr. Rajappa performed extensive basic science post-doctoral training with a specific focus on brain tumor immunology and the glioma microenvironment and his work has been published in the Journal of Clinical Investigation, Cancer Research, and Clinical Cancer Research. During his time at Weill Cornell Medicine, Dr. Rajappa was also actively involved in a large scale clinically annotated biorepository study with the Children’s Oncology Group (COG). To further his goal of developing targeted clinical trials for brain tumor patients, Dr. Rajappa obtained a Master’s of Science Degree in Clinical and Translational Investigation from Cornell University based on his experience coordinating a precision medicine program for patients with pediatric brain tumors at Weill Cornell Medicine.

Biography

Prajwal Rajappa, MD, MS, is a physician-scientist and principal investigator for the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at IGM with a focus on precision medicine and immunotherapy for patients diagnosed with Central Nervous System (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics and Neurological Surgery and member of the Translational Therapeutics Research Program at The James Comprehensive Cancer Center of The Ohio State University College of Medicine. After obtaining his MD, Dr. Rajappa completed a unique fellowship and post-doctoral training program in the Department of Neurological Surgery of Weill Cornell Medical Center and Memorial Sloan-Kettering Cancer Center. As a fellow in Neurological Surgery, his training provided him the opportunity to observe the adult and pediatric neurosurgical management of brain and spinal tumors. Dr. Rajappa performed extensive basic science post-doctoral training with a specific focus on brain tumor immunology and the glioma microenvironment and his work has been published in the Journal of Clinical Investigation, Cancer Research, and Clinical Cancer Research. During his time at Weill Cornell Medicine, Dr. Rajappa was also actively involved in a large scale clinically annotated biorepository study with the Children’s Oncology Group (COG). To further his goal of developing targeted clinical trials for brain tumor patients, Dr. Rajappa obtained a Master’s of Science Degree in Clinical and Translational Investigation from Cornell University based on his experience coordinating a precision medicine program for patients with pediatric brain tumors at Weill Cornell Medicine.

Biography

Prajwal Rajappa, MD, MS, is a physician-scientist and principal investigator for the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at IGM with a focus on precision medicine and immunotherapy for patients diagnosed with Central Nervous System (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics and Neurological Surgery and member of the Translational Therapeutics Research Program at The James Comprehensive Cancer Center of The Ohio State University College of Medicine. After obtaining his MD, Dr. Rajappa completed a unique fellowship and post-doctoral training program in the Department of Neurological Surgery of Weill Cornell Medical Center and Memorial Sloan-Kettering Cancer Center. As a fellow in Neurological Surgery, his training provided him the opportunity to observe the adult and pediatric neurosurgical management of brain and spinal tumors. Dr. Rajappa performed extensive basic science post-doctoral training with a specific focus on brain tumor immunology and the glioma microenvironment and his work has been published in the Journal of Clinical Investigation, Cancer Research, and Clinical Cancer Research. During his time at Weill Cornell Medicine, Dr. Rajappa was also actively involved in a large scale clinically annotated biorepository study with the Children’s Oncology Group (COG). To further his goal of developing targeted clinical trials for brain tumor patients, Dr. Rajappa obtained a Master’s of Science Degree in Clinical and Translational Investigation from Cornell University based on his experience coordinating a precision medicine program for patients with pediatric brain tumors at Weill Cornell Medicine.

Prajwal Rajappa, MD, MS, is a physician-scientist and principal investigator for the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at IGM with a focus on precision medicine and immunotherapy for patients diagnosed with Central Nervous System (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics and Neurological Surgery and member of the Translational Therapeutics Research Program at The James Comprehensive Cancer Center of The Ohio State University College of Medicine. After obtaining his MD, Dr. Rajappa completed a unique fellowship and post-doctoral training program in the Department of Neurological Surgery of Weill Cornell Medical Center and Memorial Sloan-Kettering Cancer Center. As a fellow in Neurological Surgery, his training provided him the opportunity to observe the adult and pediatric neurosurgical management of brain and spinal tumors. Dr. Rajappa performed extensive basic science post-doctoral training with a specific focus on brain tumor immunology and the glioma microenvironment and his work has been published in the Journal of Clinical Investigation, Cancer Research, and Clinical Cancer Research. During his time at Weill Cornell Medicine, Dr. Rajappa was also actively involved in a large scale clinically annotated biorepository study with the Children’s Oncology Group (COG). To further his goal of developing targeted clinical trials for brain tumor patients, Dr. Rajappa obtained a Master’s of Science Degree in Clinical and Translational Investigation from Cornell University based on his experience coordinating a precision medicine program for patients with pediatric brain tumors at Weill Cornell Medicine.

Prajwal Rajappa, MD, MS, is a physician-scientist and principal investigator for the Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at IGM with a focus on precision medicine and immunotherapy for patients diagnosed with Central Nervous System (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics and Neurological Surgery and member of the Translational Therapeutics Research Program at The James Comprehensive Cancer Center of The Ohio State University College of Medicine.

After obtaining his MD, Dr. Rajappa completed a unique fellowship and post-doctoral training program in the Department of Neurological Surgery of Weill Cornell Medical Center and Memorial Sloan-Kettering Cancer Center. As a fellow in Neurological Surgery, his training provided him the opportunity to observe the adult and pediatric neurosurgical management of brain and spinal tumors.

Dr. Rajappa performed extensive basic science post-doctoral training with a specific focus on brain tumor immunology and the glioma microenvironment and his work has been published in the Journal of Clinical Investigation, Cancer Research, and Clinical Cancer Research. During his time at Weill Cornell Medicine, Dr. Rajappa was also actively involved in a large scale clinically annotated biorepository study with the Children’s Oncology Group (COG).

To further his goal of developing targeted clinical trials for brain tumor patients, Dr. Rajappa obtained a Master’s of Science Degree in Clinical and Translational Investigation from Cornell University based on his experience coordinating a precision medicine program for patients with pediatric brain tumors at Weill Cornell Medicine.

Academic and Clinical Areas

Rajappa Lab

Principal Investigator

Primary Department

Institute for Genomic Medicine

Academic and Clinical Areas

Rajappa Lab

Principal Investigator

Primary Department

Institute for Genomic Medicine

Academic and Clinical Areas

Rajappa Lab

Principal Investigator

Primary Department

Institute for Genomic Medicine

Rajappa Lab

Principal Investigator

Primary Department

Institute for Genomic Medicine

  • Rajappa Lab
  • Principal Investigator
  • Primary Department
  • Institute for Genomic Medicine

Awards, Honors & Organizations

Pediatric Precision Oncology Award, Alex’s Lemonade Stand Foundation, 2018 Member, Society for Neuro-Oncology, 2019 - Present Member, American Association for Cancer Research, 2019 - Present

Awards, Honors & Organizations

Pediatric Precision Oncology Award, Alex’s Lemonade Stand Foundation, 2018 Member, Society for Neuro-Oncology, 2019 - Present Member, American Association for Cancer Research, 2019 - Present

Awards, Honors & Organizations

Pediatric Precision Oncology Award, Alex’s Lemonade Stand Foundation, 2018 Member, Society for Neuro-Oncology, 2019 - Present Member, American Association for Cancer Research, 2019 - Present

Pediatric Precision Oncology Award, Alex’s Lemonade Stand Foundation, 2018 Member, Society for Neuro-Oncology, 2019 - Present Member, American Association for Cancer Research, 2019 - Present

  • Pediatric Precision Oncology Award, Alex’s Lemonade Stand Foundation, 2018
  • Member, Society for Neuro-Oncology, 2019 - Present
  • Member, American Association for Cancer Research, 2019 - Present

Research

Interests

Adult and Pediatric Brain Tumors Genomic Medicine Next-Generation Sequencing (NGS) Tumor Immunology Tumor Microenvironment

Dr. Rajappa is a physician-scientist and principal investigator in the Steve and Cindy Rasmussen Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at the IGM with a focus on precision medicine and immunotherapy for patients diagnosed with central nervous system (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics at The Ohio State University College of Medicine and faculty member of the Translational Therapeutics Research Program at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. Publications

                  Kalathoor S, Rajendran S, Canella A, Raval R, Cripe TP, Mardis ER, Rajappa P. Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors. J Neuroimmunol. 2022 Dec 5; 374: 578009.

                


                  Rajappa P, Eng KW, Bareja R, Bander ED, Yuan M, Dua A, Bhanu Maachani U, Snuderl M, Pan H, Zhang T, Tosi U, Ivasyk I, Souweidane MM, Elemento O, Sboner A, Greenfield JP, Pisapia DJ. Utility of multimodality molecular profiling for pediatric patients with central nervous system tumors. Neurooncol Adv. 2022 Jan-Dec; 4: vdac031.

                


                  Aggarwal P, Luo W, Pehlivan KC, Hoang H, Rajappa P, Cripe TP, Cassady KA, Lee DA, Cairo MS. Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations. Front Immunol. 2022; 13: 1038096.

                


                  Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse J, Pisapia DJ, Chan TA, Lyden DC, Bromberg JF, Greenfield JP. Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells. Clin Cancer Res. 2017 Jun 15; 23: 3109-3119.

                


                  Huang Y, Rajappa P, Hu W, Hoffman C, Cisse B, Kim JH, Gorge E, Yanowitch R, Cope W, Vartanian E, Xu R, Zhang T, Pisapia D, Xiang J, Huse J, Matei I, Peinado H, Bromberg J, Holland E, Ding BS, Rafii S, Lyden D, Greenfield J. A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. J Clin Invest. 2017 May 1; 127: 1826-1838.

                


                  Kossatz S, Carney B, Schweitzer M, Carlucci G, Miloushev VZ, Maachani UB, Rajappa P, Keshari KR, Pisapia D, Weber WA, Souweidane MM, Reiner T. Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models. Cancer Res. 2017 Apr 15; 77: 2112-2123.

                


                  Pisapia DJ, Salvatore S, Pauli C, Hissong E, Eng K, Prandi D, Sailer VW, Robinson BD, Park K, Cyrta J, Tagawa ST, Kossai M, Fontugne J, Kim R, Sigaras A, Rao R, Pancirer D, Faltas B, Bareja R, Molina AM, Nanus DM, Rajappa P, Souweidane MM, Greenfield J, Emde AK, Robine N, Elemento O, Sboner A, Demichelis F, Beltran H, Rubin MA, Mosquera JM. Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models. JCO Precis Oncol. 2017; 2017:

View More Publications

Research

Interests

Adult and Pediatric Brain Tumors Genomic Medicine Next-Generation Sequencing (NGS) Tumor Immunology Tumor Microenvironment

Dr. Rajappa is a physician-scientist and principal investigator in the Steve and Cindy Rasmussen Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at the IGM with a focus on precision medicine and immunotherapy for patients diagnosed with central nervous system (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics at The Ohio State University College of Medicine and faculty member of the Translational Therapeutics Research Program at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. Publications

                  Kalathoor S, Rajendran S, Canella A, Raval R, Cripe TP, Mardis ER, Rajappa P. Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors. J Neuroimmunol. 2022 Dec 5; 374: 578009.

                


                  Rajappa P, Eng KW, Bareja R, Bander ED, Yuan M, Dua A, Bhanu Maachani U, Snuderl M, Pan H, Zhang T, Tosi U, Ivasyk I, Souweidane MM, Elemento O, Sboner A, Greenfield JP, Pisapia DJ. Utility of multimodality molecular profiling for pediatric patients with central nervous system tumors. Neurooncol Adv. 2022 Jan-Dec; 4: vdac031.

                


                  Aggarwal P, Luo W, Pehlivan KC, Hoang H, Rajappa P, Cripe TP, Cassady KA, Lee DA, Cairo MS. Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations. Front Immunol. 2022; 13: 1038096.

                


                  Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse J, Pisapia DJ, Chan TA, Lyden DC, Bromberg JF, Greenfield JP. Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells. Clin Cancer Res. 2017 Jun 15; 23: 3109-3119.

                


                  Huang Y, Rajappa P, Hu W, Hoffman C, Cisse B, Kim JH, Gorge E, Yanowitch R, Cope W, Vartanian E, Xu R, Zhang T, Pisapia D, Xiang J, Huse J, Matei I, Peinado H, Bromberg J, Holland E, Ding BS, Rafii S, Lyden D, Greenfield J. A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. J Clin Invest. 2017 May 1; 127: 1826-1838.

                


                  Kossatz S, Carney B, Schweitzer M, Carlucci G, Miloushev VZ, Maachani UB, Rajappa P, Keshari KR, Pisapia D, Weber WA, Souweidane MM, Reiner T. Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models. Cancer Res. 2017 Apr 15; 77: 2112-2123.

                


                  Pisapia DJ, Salvatore S, Pauli C, Hissong E, Eng K, Prandi D, Sailer VW, Robinson BD, Park K, Cyrta J, Tagawa ST, Kossai M, Fontugne J, Kim R, Sigaras A, Rao R, Pancirer D, Faltas B, Bareja R, Molina AM, Nanus DM, Rajappa P, Souweidane MM, Greenfield J, Emde AK, Robine N, Elemento O, Sboner A, Demichelis F, Beltran H, Rubin MA, Mosquera JM. Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models. JCO Precis Oncol. 2017; 2017:

View More Publications

Research

Interests

Adult and Pediatric Brain Tumors Genomic Medicine Next-Generation Sequencing (NGS) Tumor Immunology Tumor Microenvironment

Dr. Rajappa is a physician-scientist and principal investigator in the Steve and Cindy Rasmussen Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at the IGM with a focus on precision medicine and immunotherapy for patients diagnosed with central nervous system (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics at The Ohio State University College of Medicine and faculty member of the Translational Therapeutics Research Program at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. Publications

                  Kalathoor S, Rajendran S, Canella A, Raval R, Cripe TP, Mardis ER, Rajappa P. Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors. J Neuroimmunol. 2022 Dec 5; 374: 578009.

                


                  Rajappa P, Eng KW, Bareja R, Bander ED, Yuan M, Dua A, Bhanu Maachani U, Snuderl M, Pan H, Zhang T, Tosi U, Ivasyk I, Souweidane MM, Elemento O, Sboner A, Greenfield JP, Pisapia DJ. Utility of multimodality molecular profiling for pediatric patients with central nervous system tumors. Neurooncol Adv. 2022 Jan-Dec; 4: vdac031.

                


                  Aggarwal P, Luo W, Pehlivan KC, Hoang H, Rajappa P, Cripe TP, Cassady KA, Lee DA, Cairo MS. Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations. Front Immunol. 2022; 13: 1038096.

                


                  Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse J, Pisapia DJ, Chan TA, Lyden DC, Bromberg JF, Greenfield JP. Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells. Clin Cancer Res. 2017 Jun 15; 23: 3109-3119.

                


                  Huang Y, Rajappa P, Hu W, Hoffman C, Cisse B, Kim JH, Gorge E, Yanowitch R, Cope W, Vartanian E, Xu R, Zhang T, Pisapia D, Xiang J, Huse J, Matei I, Peinado H, Bromberg J, Holland E, Ding BS, Rafii S, Lyden D, Greenfield J. A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. J Clin Invest. 2017 May 1; 127: 1826-1838.

                


                  Kossatz S, Carney B, Schweitzer M, Carlucci G, Miloushev VZ, Maachani UB, Rajappa P, Keshari KR, Pisapia D, Weber WA, Souweidane MM, Reiner T. Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models. Cancer Res. 2017 Apr 15; 77: 2112-2123.

                


                  Pisapia DJ, Salvatore S, Pauli C, Hissong E, Eng K, Prandi D, Sailer VW, Robinson BD, Park K, Cyrta J, Tagawa ST, Kossai M, Fontugne J, Kim R, Sigaras A, Rao R, Pancirer D, Faltas B, Bareja R, Molina AM, Nanus DM, Rajappa P, Souweidane MM, Greenfield J, Emde AK, Robine N, Elemento O, Sboner A, Demichelis F, Beltran H, Rubin MA, Mosquera JM. Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models. JCO Precis Oncol. 2017; 2017:

View More Publications

Interests

Adult and Pediatric Brain Tumors Genomic Medicine Next-Generation Sequencing (NGS) Tumor Immunology Tumor Microenvironment

Dr. Rajappa is a physician-scientist and principal investigator in the Steve and Cindy Rasmussen Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at the IGM with a focus on precision medicine and immunotherapy for patients diagnosed with central nervous system (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics at The Ohio State University College of Medicine and faculty member of the Translational Therapeutics Research Program at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. Publications

                  Kalathoor S, Rajendran S, Canella A, Raval R, Cripe TP, Mardis ER, Rajappa P. Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors. J Neuroimmunol. 2022 Dec 5; 374: 578009.

                


                  Rajappa P, Eng KW, Bareja R, Bander ED, Yuan M, Dua A, Bhanu Maachani U, Snuderl M, Pan H, Zhang T, Tosi U, Ivasyk I, Souweidane MM, Elemento O, Sboner A, Greenfield JP, Pisapia DJ. Utility of multimodality molecular profiling for pediatric patients with central nervous system tumors. Neurooncol Adv. 2022 Jan-Dec; 4: vdac031.

                


                  Aggarwal P, Luo W, Pehlivan KC, Hoang H, Rajappa P, Cripe TP, Cassady KA, Lee DA, Cairo MS. Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations. Front Immunol. 2022; 13: 1038096.

                


                  Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse J, Pisapia DJ, Chan TA, Lyden DC, Bromberg JF, Greenfield JP. Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells. Clin Cancer Res. 2017 Jun 15; 23: 3109-3119.

                


                  Huang Y, Rajappa P, Hu W, Hoffman C, Cisse B, Kim JH, Gorge E, Yanowitch R, Cope W, Vartanian E, Xu R, Zhang T, Pisapia D, Xiang J, Huse J, Matei I, Peinado H, Bromberg J, Holland E, Ding BS, Rafii S, Lyden D, Greenfield J. A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. J Clin Invest. 2017 May 1; 127: 1826-1838.

                


                  Kossatz S, Carney B, Schweitzer M, Carlucci G, Miloushev VZ, Maachani UB, Rajappa P, Keshari KR, Pisapia D, Weber WA, Souweidane MM, Reiner T. Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models. Cancer Res. 2017 Apr 15; 77: 2112-2123.

                


                  Pisapia DJ, Salvatore S, Pauli C, Hissong E, Eng K, Prandi D, Sailer VW, Robinson BD, Park K, Cyrta J, Tagawa ST, Kossai M, Fontugne J, Kim R, Sigaras A, Rao R, Pancirer D, Faltas B, Bareja R, Molina AM, Nanus DM, Rajappa P, Souweidane MM, Greenfield J, Emde AK, Robine N, Elemento O, Sboner A, Demichelis F, Beltran H, Rubin MA, Mosquera JM. Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models. JCO Precis Oncol. 2017; 2017:

View More Publications

Interests

Adult and Pediatric Brain Tumors Genomic Medicine Next-Generation Sequencing (NGS) Tumor Immunology Tumor Microenvironment

Dr. Rajappa is a physician-scientist and principal investigator in the Steve and Cindy Rasmussen Institute for Genomic Medicine (IGM) at Nationwide Children’s Hospital. He directs the Rajappa Laboratory at the IGM with a focus on precision medicine and immunotherapy for patients diagnosed with central nervous system (CNS) tumors. Dr. Rajappa is also an assistant professor of Pediatrics at The Ohio State University College of Medicine and faculty member of the Translational Therapeutics Research Program at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

Interests

Adult and Pediatric Brain Tumors Genomic Medicine Next-Generation Sequencing (NGS) Tumor Immunology Tumor Microenvironment

  • Adult and Pediatric Brain Tumors

  • Genomic Medicine

  • Next-Generation Sequencing (NGS)

  • Tumor Immunology

  • Tumor Microenvironment

                   Kalathoor S, Rajendran S, Canella A, Raval R, Cripe TP, Mardis ER, Rajappa P. Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors. J Neuroimmunol. 2022 Dec 5; 374: 578009.



               Rajappa P, Eng KW, Bareja R, Bander ED, Yuan M, Dua A, Bhanu Maachani U, Snuderl M, Pan H, Zhang T, Tosi U, Ivasyk I, Souweidane MM, Elemento O, Sboner A, Greenfield JP, Pisapia DJ. Utility of multimodality molecular profiling for pediatric patients with central nervous system tumors. Neurooncol Adv. 2022 Jan-Dec; 4: vdac031.



               Aggarwal P, Luo W, Pehlivan KC, Hoang H, Rajappa P, Cripe TP, Cassady KA, Lee DA, Cairo MS. Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations. Front Immunol. 2022; 13: 1038096.



               Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse J, Pisapia DJ, Chan TA, Lyden DC, Bromberg JF, Greenfield JP. Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells. Clin Cancer Res. 2017 Jun 15; 23: 3109-3119.



               Huang Y, Rajappa P, Hu W, Hoffman C, Cisse B, Kim JH, Gorge E, Yanowitch R, Cope W, Vartanian E, Xu R, Zhang T, Pisapia D, Xiang J, Huse J, Matei I, Peinado H, Bromberg J, Holland E, Ding BS, Rafii S, Lyden D, Greenfield J. A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. J Clin Invest. 2017 May 1; 127: 1826-1838.



               Kossatz S, Carney B, Schweitzer M, Carlucci G, Miloushev VZ, Maachani UB, Rajappa P, Keshari KR, Pisapia D, Weber WA, Souweidane MM, Reiner T. Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models. Cancer Res. 2017 Apr 15; 77: 2112-2123.



               Pisapia DJ, Salvatore S, Pauli C, Hissong E, Eng K, Prandi D, Sailer VW, Robinson BD, Park K, Cyrta J, Tagawa ST, Kossai M, Fontugne J, Kim R, Sigaras A, Rao R, Pancirer D, Faltas B, Bareja R, Molina AM, Nanus DM, Rajappa P, Souweidane MM, Greenfield J, Emde AK, Robine N, Elemento O, Sboner A, Demichelis F, Beltran H, Rubin MA, Mosquera JM. Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models. JCO Precis Oncol. 2017; 2017:

View More Publications

  • Kalathoor S, Rajendran S, Canella A, Raval R, Cripe TP, Mardis ER, Rajappa P. Myeloid cell heterogeneity in the tumor microenvironment and therapeutic implications for childhood central nervous system (CNS) tumors. J Neuroimmunol. 2022 Dec 5; 374: 578009.
  • Rajappa P, Eng KW, Bareja R, Bander ED, Yuan M, Dua A, Bhanu Maachani U, Snuderl M, Pan H, Zhang T, Tosi U, Ivasyk I, Souweidane MM, Elemento O, Sboner A, Greenfield JP, Pisapia DJ. Utility of multimodality molecular profiling for pediatric patients with central nervous system tumors. Neurooncol Adv. 2022 Jan-Dec; 4: vdac031.
  • Aggarwal P, Luo W, Pehlivan KC, Hoang H, Rajappa P, Cripe TP, Cassady KA, Lee DA, Cairo MS. Pediatric versus adult high grade glioma: Immunotherapeutic and genomic considerations. Front Immunol. 2022; 13: 1038096.
  • Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse J, Pisapia DJ, Chan TA, Lyden DC, Bromberg JF, Greenfield JP. Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells. Clin Cancer Res. 2017 Jun 15; 23: 3109-3119.
  • Huang Y, Rajappa P, Hu W, Hoffman C, Cisse B, Kim JH, Gorge E, Yanowitch R, Cope W, Vartanian E, Xu R, Zhang T, Pisapia D, Xiang J, Huse J, Matei I, Peinado H, Bromberg J, Holland E, Ding BS, Rafii S, Lyden D, Greenfield J. A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. J Clin Invest. 2017 May 1; 127: 1826-1838.
  • Kossatz S, Carney B, Schweitzer M, Carlucci G, Miloushev VZ, Maachani UB, Rajappa P, Keshari KR, Pisapia D, Weber WA, Souweidane MM, Reiner T. Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models. Cancer Res. 2017 Apr 15; 77: 2112-2123.
  • Pisapia DJ, Salvatore S, Pauli C, Hissong E, Eng K, Prandi D, Sailer VW, Robinson BD, Park K, Cyrta J, Tagawa ST, Kossai M, Fontugne J, Kim R, Sigaras A, Rao R, Pancirer D, Faltas B, Bareja R, Molina AM, Nanus DM, Rajappa P, Souweidane MM, Greenfield J, Emde AK, Robine N, Elemento O, Sboner A, Demichelis F, Beltran H, Rubin MA, Mosquera JM. Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models. JCO Precis Oncol. 2017; 2017:

Education

Date of Appointment at Nationwide Children’s Hospital: 09/30/2019

Postdoctoral Training

Weill Cornell Medical College of Cornell University

Date Completed: 07/31/2019

Graduate School

Weill Cornell Medical College of Cornell University

Date Completed: 05/31/2019

Medical School

St. George’s University School of Medicine

Date Completed: 12/31/2010

Education

Date of Appointment at Nationwide Children’s Hospital: 09/30/2019

Postdoctoral Training

Weill Cornell Medical College of Cornell University

Date Completed: 07/31/2019

Graduate School

Weill Cornell Medical College of Cornell University

Date Completed: 05/31/2019

Medical School

St. George’s University School of Medicine

Date Completed: 12/31/2010

Education

Date of Appointment at Nationwide Children’s Hospital: 09/30/2019

Postdoctoral Training

Weill Cornell Medical College of Cornell University

Date Completed: 07/31/2019

Graduate School

Weill Cornell Medical College of Cornell University

Date Completed: 05/31/2019

Medical School

St. George’s University School of Medicine

Date Completed: 12/31/2010

Date of Appointment at Nationwide Children’s Hospital: 09/30/2019

Postdoctoral Training

Weill Cornell Medical College of Cornell University

Date Completed: 07/31/2019

Graduate School

Weill Cornell Medical College of Cornell University

Date Completed: 05/31/2019

Medical School

St. George’s University School of Medicine

Date Completed: 12/31/2010

Date of Appointment at Nationwide Children’s Hospital: 09/30/2019

Postdoctoral Training

Weill Cornell Medical College of Cornell University

Date Completed: 07/31/2019

Graduate School

Weill Cornell Medical College of Cornell University

Date Completed: 05/31/2019

Medical School

St. George’s University School of Medicine

Date Completed: 12/31/2010

Clinical Interests

Clinical Trials Immuno-Oncology Immunotherapy Intra-arterial Drug Delivery Low Grade Gliomas Precision Medicine

Clinical Interests

Clinical Trials Immuno-Oncology Immunotherapy Intra-arterial Drug Delivery Low Grade Gliomas Precision Medicine

Clinical Interests

Clinical Trials Immuno-Oncology Immunotherapy Intra-arterial Drug Delivery Low Grade Gliomas Precision Medicine

Clinical Trials Immuno-Oncology Immunotherapy Intra-arterial Drug Delivery Low Grade Gliomas Precision Medicine

  • Clinical Trials
  • Immuno-Oncology
  • Immunotherapy
  • Intra-arterial Drug Delivery
  • Low Grade Gliomas
  • Precision Medicine

Contact Information

Institute for Genomic Medicine

Call us at: (614) 355-5936

                    700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Institute for Genomic Medicine

Call us at: (614) 355-5936

                    700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Institute for Genomic Medicine

Call us at: (614) 355-5936

                    700 Children's DriveColumbus, OH 43205 (map)

Institute for Genomic Medicine

Call us at: (614) 355-5936

                    700 Children's DriveColumbus, OH 43205 (map)

Call us at: (614) 355-5936

                    700 Children's DriveColumbus, OH 43205 (map)

Call us at: (614) 355-5936

                    700 Children's DriveColumbus, OH 43205 (map)
  • Call us at:
  • (614) 355-5936
  • 700 Children’s DriveColumbus, OH 43205 (map)

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