Mouse Model Could Help Identify Viral Vectors That May Cause Tumors
Investigators at Nationwide Children’s Hospital have identified a mouse model that could help evaluate the risk that viral vectors used in gene therapy might promote tumor formation as a side-effect. The study appears in Molecular Therapy. Modified viruses used to deliver genetic material into cells, known as viral vectors, have become the go-to delivery capsule in gene therapy. Capitalizing on their viral nature, investigators use viral vectors to efficiently target certain cells and deliver genetic material into the cell nucleus where native genes reside....