A Single Dose Cancer Immunotherapy Via Gene Transfer
(COLUMBUS, Ohio) - Researchers at Nationwide Children’s Hospital report proof-of-principle results for a new gene therapy cancer treatment. The off-the-shelf, single-dose immunotherapy serves as an alternative to CAR-T therapy and can be engineered to be on-demand. T cells redirected to cancer cells either via a chimeric antigen receptor (CAR-T) or a bispecific molecule have been game-changers in treating certain leukemias and lymphomas. Even so, there are challenges associated with these treatments; CAR-T cells are expensive and cumbersome to manufacture, for instance, while bispecifics require long infusions....