Contact Information

Call us at: (614) 722-4360

Fax us at: (614) 722-6482

PediatricsNephrology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Michael Brian Becknell

Biography

M. Brian Becknell, MD, PhD, is a pediatric nephrologist at Nationwide Children’s and principal investigator for the Kidney and Urinary Tract Center. He is also an assistant professor of pediatrics for The Ohio State University College of Medicine, where he received his medical degree. Dr. Becknell completed his residency and pediatric nephrology fellowship at Nationwide Children’s. His clinical interests include pyelonephritis and congenital obstructive nephropathy. Dr. Becknell’s research interests include understanding the mechanisms responsible for deterioration of kidney function in children with congenital obstructive nephropathy.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English German

Academic and Clinical Areas

Nephrology and Hypertension

Physician Team

Nephrology Fellowship

Faculty

Nephrology and Urology Research Affinity Group

Faculty

Kidney and Urinary Tract Center Team

Research Director

Becknell Lab

Principal Investigator

Primary Department

Pediatrics

Primary Section

Nephrology and Hypertension

Awards, Honors & Organizations

Kenney Award, Best Abstract Presentation by a Pediatric Fellow, Midwest Society for Pediatric Research, 2012 NIH Loan Repayment Program Award,, NIDDK, 2012 Travel Grant, Society for Pediatric Research, 2012 Resident Teaching Award, Department of Pediatrics, Ohio State University College of Medicine, 2011 Outstanding Resident Publication Award, Nationwide Children’s Hospital, 2011 NIH Loan Repayment Program Award, NIDDK, 2010 Resident Research Grant, American Academy of Pediatrics, 2010 Intramural Grant, Nationwide Children’s Hospital Research Institute, 2010 House Officer Research Award, Society for Pediatric Research, 2010 Invited Resident, Association of Medical School Pediatric Department Chairs (AMSPDC) Frontiers in Science, 2010 Invited Resident Travel Grant, American Society for Nephrology, 2009 Travel Grant, Pediatric Nephrology Seminar, University of Miami Leonard M. Miller School of Medicine, 2009 Medical Scientist Award, The Ohio State University College of Medicine, 2008 MD/PhD Leadership and Academic Achievement Scholarship, The Ohio State University College of Medicine, 2008 Outstanding Academic Merit Scholarship, The Ohio State University College of Medicine, 2008 Grant Morrow III, MD Award, Department of Pediatrics, The Ohio State University College of Medicine, 2008 Travel Award, American Society of Hematology, 2004 Dean’s Distinguished University Fellowship, The Ohio State University, Graduate School of Arts and Sciences, 1999 Bennett Fellowship, The Ohio State University College of Medicine, 1999 Medical Scientist Fellowship, The Ohio State University College of Medicine, 1999 National Science Foundation (NSF) Predoctoral Fellowship, 1998 Member, Alpha Omega Alpha, The Ohio State University College of Medicine, 2008 - Present Member, Landacre Society, The Ohio State University College of Medicine, 2007 - Present Member, Phi Beta Kappa, Kenyon College, 1997 - Present

Research

Lab(s)

Becknell Lab

Publications

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

                


                  Sebastião YV, Cooper JN, Becknell B, Ching CB, McLeod DJ. Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy. Pediatr Nephrol. 2021 Jan; 36: 111-118.

                


                  McLeod DJ, Sebastião YV, Ching CB, Greenberg JH, Furth SL, Becknell B. Longitudinal kidney injury biomarker trajectories in children with obstructive uropathy. Pediatr Nephrol. 2020 Oct; 35: 1907-1914.

                


                  Gupta S, Nicassio L, Junquera GY, Jackson AR, Fuchs M, McLeod D, Alpert S, Jayanthi VR, DaJusta D, McHugh KM, Becknell B, Ching CB. Impact of successful pediatric ureteropelvic junction obstruction surgery on urinary HIP/PAP and BD-1 levels. J Pediatr Urol. 2020 Oct; 16: 592.e1-592.e7.

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Ching C, Schwartz L, Spencer JD, Becknell B. Innate immunity and urinary tract infection. Pediatr Nephrol. 2020 Jul; 35: 1183-1192.

                


                  Millner RO, Preece J, Salvator A, McLeod DJ, Ching CB, Becknell B. Albuminuria in Pediatric Neurogenic Bladder: Identifying an Earlier Marker of Renal Disease. Urology. 2019 Nov; 133: 199-203.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Eichler T, Bender K, Murtha MJ, Schwartz L, Metheny J, Solden L, Jaggers RM, Bailey MT, Gupta S, Mosquera C, Ching C, La Perle K, Li B, Becknell B, Spencer JD. Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection. J Am Soc Nephrol. 2019 Aug; 30: 1385-1397.

                


                  Pottanat ND, Brook AC, Bartosova M, Cortado H, Gupta S, Li B, Jackson AR, Vonau M, Cohen S, Ferrara M, Ching CB, Spencer JD, Brauner A, Fraser DJ, Schmitt CP, Eberl M, Ayoob R, Becknell B. Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis. Sci Rep. 2019 May 23; 9: 7753.

                


                  McLeod DJ, Ching CB, Sebastião YV, Greenberg JH, Furth SL, McHugh KM, Becknell B. Common clinical markers predict end-stage renal disease in children with obstructive uropathy. Pediatr Nephrol. 2019 Mar; 34: 443-448.

                


                  Becknell B, Ching C, Spencer JD. The Responses of the Ribonuclease A Superfamily to Urinary Tract Infection. Front Immunol. 2019; 10: 2786.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Ching CB, Becknell B. Novel role for androgen signaling in pyelonephritis. Kidney Int. 2018 Sep; 94: 455-457.

                


                  Ching CB, Gupta S, Li B, Cortado H, Mayne N, Jackson AR, McHugh KM, Becknell B. Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection. Kidney Int. 2018 Jun; 93: 1320-1329.

                


                  Barua M, John R, Stella L, Li W, Roslin NM, Sharif B, Hack S, Lajoie-Starkell G, Schwaderer AL, Becknell B, Wuttke M, Köttgen A, Cattran D, Paterson AD, Pei Y. X-Linked Glomerulopathy Due to COL4A5 Founder Variant. Am J Kidney Dis. 2018 Mar; 71: 441-445.

                


                  Saxena V, Hains DS, Ketz J, Chanley M, Spencer JD, Becknell B, Pierce KR, Nelson RD, Purkerson JM, Schwartz GJ, Schwaderer AL. Cell specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct. Am J Physiol Renal Physiol. 2017 May 3;  ajprenal005122016.

                


                  Li B, Haridas B, Jackson AR, Cortado H, Mayne N, Kohnken R, Bolon B, McHugh KM, Schwaderer AL, Spencer JD, Ching CB, Hains DS, Justice SS, Partida-Sanchez S, Becknell B. Inflammation drives renal scarring in experimental pyelonephritis. Am J Physiol Renal Physiol. 2017 Jan 1; 312: F43-F53.

                


                  Schwaderer AL, Wang H, Kim S, Kline JM, Liang D, Brophy PD, McHugh KM, Tseng GC, Saxena V, Barr-Beare E, Pierce KR, Shaikh N, Manak JR, Cohen DM, Becknell B, Spencer JD, Baker PB, Yu CY, Hains DS. Polymorphisms in a-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux. J Am Soc Nephrol. 2016 Oct; 27: 3175-3186.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Mojica MF, Ouellette CP, Leber A, Becknell MB, Ardura MI, Perez F, Shimamura M, Bonomo RA, Aitken SL, Shelburne SA. Successful Treatment of Bloodstream Infection Due to Metallo-ß-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient. Antimicrob Agents Chemother. 2016 Sep; 60: 5130-4.

                


                  Eichler TE, Becknell B, Easterling RS, Ingraham SE, Cohen DM, Schwaderer AL, Hains DS, Li B, Cohen A, Metheny J, Tridandapani S, Spencer JD. Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract. Kidney Int. 2016 Sep; 90: 568-79.

                


                  Gordon ZN, McLeod DJ, Ching CB, Herz DB, Bates DG, Becknell B, Alpert SA. Uroepithelial thickening improves detection of vesicoureteral reflux in infants with prenatal hydronephrosis. J Pediatr Urol. 2016 Aug; 12: 257.e1-7.

                


                  Becknell B, Spencer JD. A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense. Int J Mol Sci. 2016 Mar 22; 17: 423.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2013

Board Certifications

Pediatric Nephrology Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2013

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Medical School

Ohio State University College of Medicine

Date Completed: 06/08/2008

Contact Information

Pediatrics

Call us at: (614) 722-4360

Fax us at: (614) 722-6482

                    Nephrology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-4360

Fax us at: (614) 722-6482

PediatricsNephrology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Michael Brian Becknell

Biography

M. Brian Becknell, MD, PhD, is a pediatric nephrologist at Nationwide Children’s and principal investigator for the Kidney and Urinary Tract Center. He is also an assistant professor of pediatrics for The Ohio State University College of Medicine, where he received his medical degree. Dr. Becknell completed his residency and pediatric nephrology fellowship at Nationwide Children’s. His clinical interests include pyelonephritis and congenital obstructive nephropathy. Dr. Becknell’s research interests include understanding the mechanisms responsible for deterioration of kidney function in children with congenital obstructive nephropathy.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English German

Academic and Clinical Areas

Nephrology and Hypertension

Physician Team

Nephrology Fellowship

Faculty

Nephrology and Urology Research Affinity Group

Faculty

Kidney and Urinary Tract Center Team

Research Director

Becknell Lab

Principal Investigator

Primary Department

Pediatrics

Primary Section

Nephrology and Hypertension

Awards, Honors & Organizations

Kenney Award, Best Abstract Presentation by a Pediatric Fellow, Midwest Society for Pediatric Research, 2012 NIH Loan Repayment Program Award,, NIDDK, 2012 Travel Grant, Society for Pediatric Research, 2012 Resident Teaching Award, Department of Pediatrics, Ohio State University College of Medicine, 2011 Outstanding Resident Publication Award, Nationwide Children’s Hospital, 2011 NIH Loan Repayment Program Award, NIDDK, 2010 Resident Research Grant, American Academy of Pediatrics, 2010 Intramural Grant, Nationwide Children’s Hospital Research Institute, 2010 House Officer Research Award, Society for Pediatric Research, 2010 Invited Resident, Association of Medical School Pediatric Department Chairs (AMSPDC) Frontiers in Science, 2010 Invited Resident Travel Grant, American Society for Nephrology, 2009 Travel Grant, Pediatric Nephrology Seminar, University of Miami Leonard M. Miller School of Medicine, 2009 Medical Scientist Award, The Ohio State University College of Medicine, 2008 MD/PhD Leadership and Academic Achievement Scholarship, The Ohio State University College of Medicine, 2008 Outstanding Academic Merit Scholarship, The Ohio State University College of Medicine, 2008 Grant Morrow III, MD Award, Department of Pediatrics, The Ohio State University College of Medicine, 2008 Travel Award, American Society of Hematology, 2004 Dean’s Distinguished University Fellowship, The Ohio State University, Graduate School of Arts and Sciences, 1999 Bennett Fellowship, The Ohio State University College of Medicine, 1999 Medical Scientist Fellowship, The Ohio State University College of Medicine, 1999 National Science Foundation (NSF) Predoctoral Fellowship, 1998 Member, Alpha Omega Alpha, The Ohio State University College of Medicine, 2008 - Present Member, Landacre Society, The Ohio State University College of Medicine, 2007 - Present Member, Phi Beta Kappa, Kenyon College, 1997 - Present

Research

Lab(s)

Becknell Lab

Publications

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

                


                  Sebastião YV, Cooper JN, Becknell B, Ching CB, McLeod DJ. Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy. Pediatr Nephrol. 2021 Jan; 36: 111-118.

                


                  McLeod DJ, Sebastião YV, Ching CB, Greenberg JH, Furth SL, Becknell B. Longitudinal kidney injury biomarker trajectories in children with obstructive uropathy. Pediatr Nephrol. 2020 Oct; 35: 1907-1914.

                


                  Gupta S, Nicassio L, Junquera GY, Jackson AR, Fuchs M, McLeod D, Alpert S, Jayanthi VR, DaJusta D, McHugh KM, Becknell B, Ching CB. Impact of successful pediatric ureteropelvic junction obstruction surgery on urinary HIP/PAP and BD-1 levels. J Pediatr Urol. 2020 Oct; 16: 592.e1-592.e7.

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Ching C, Schwartz L, Spencer JD, Becknell B. Innate immunity and urinary tract infection. Pediatr Nephrol. 2020 Jul; 35: 1183-1192.

                


                  Millner RO, Preece J, Salvator A, McLeod DJ, Ching CB, Becknell B. Albuminuria in Pediatric Neurogenic Bladder: Identifying an Earlier Marker of Renal Disease. Urology. 2019 Nov; 133: 199-203.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Eichler T, Bender K, Murtha MJ, Schwartz L, Metheny J, Solden L, Jaggers RM, Bailey MT, Gupta S, Mosquera C, Ching C, La Perle K, Li B, Becknell B, Spencer JD. Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection. J Am Soc Nephrol. 2019 Aug; 30: 1385-1397.

                


                  Pottanat ND, Brook AC, Bartosova M, Cortado H, Gupta S, Li B, Jackson AR, Vonau M, Cohen S, Ferrara M, Ching CB, Spencer JD, Brauner A, Fraser DJ, Schmitt CP, Eberl M, Ayoob R, Becknell B. Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis. Sci Rep. 2019 May 23; 9: 7753.

                


                  McLeod DJ, Ching CB, Sebastião YV, Greenberg JH, Furth SL, McHugh KM, Becknell B. Common clinical markers predict end-stage renal disease in children with obstructive uropathy. Pediatr Nephrol. 2019 Mar; 34: 443-448.

                


                  Becknell B, Ching C, Spencer JD. The Responses of the Ribonuclease A Superfamily to Urinary Tract Infection. Front Immunol. 2019; 10: 2786.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Ching CB, Becknell B. Novel role for androgen signaling in pyelonephritis. Kidney Int. 2018 Sep; 94: 455-457.

                


                  Ching CB, Gupta S, Li B, Cortado H, Mayne N, Jackson AR, McHugh KM, Becknell B. Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection. Kidney Int. 2018 Jun; 93: 1320-1329.

                


                  Barua M, John R, Stella L, Li W, Roslin NM, Sharif B, Hack S, Lajoie-Starkell G, Schwaderer AL, Becknell B, Wuttke M, Köttgen A, Cattran D, Paterson AD, Pei Y. X-Linked Glomerulopathy Due to COL4A5 Founder Variant. Am J Kidney Dis. 2018 Mar; 71: 441-445.

                


                  Saxena V, Hains DS, Ketz J, Chanley M, Spencer JD, Becknell B, Pierce KR, Nelson RD, Purkerson JM, Schwartz GJ, Schwaderer AL. Cell specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct. Am J Physiol Renal Physiol. 2017 May 3;  ajprenal005122016.

                


                  Li B, Haridas B, Jackson AR, Cortado H, Mayne N, Kohnken R, Bolon B, McHugh KM, Schwaderer AL, Spencer JD, Ching CB, Hains DS, Justice SS, Partida-Sanchez S, Becknell B. Inflammation drives renal scarring in experimental pyelonephritis. Am J Physiol Renal Physiol. 2017 Jan 1; 312: F43-F53.

                


                  Schwaderer AL, Wang H, Kim S, Kline JM, Liang D, Brophy PD, McHugh KM, Tseng GC, Saxena V, Barr-Beare E, Pierce KR, Shaikh N, Manak JR, Cohen DM, Becknell B, Spencer JD, Baker PB, Yu CY, Hains DS. Polymorphisms in a-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux. J Am Soc Nephrol. 2016 Oct; 27: 3175-3186.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Mojica MF, Ouellette CP, Leber A, Becknell MB, Ardura MI, Perez F, Shimamura M, Bonomo RA, Aitken SL, Shelburne SA. Successful Treatment of Bloodstream Infection Due to Metallo-ß-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient. Antimicrob Agents Chemother. 2016 Sep; 60: 5130-4.

                


                  Eichler TE, Becknell B, Easterling RS, Ingraham SE, Cohen DM, Schwaderer AL, Hains DS, Li B, Cohen A, Metheny J, Tridandapani S, Spencer JD. Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract. Kidney Int. 2016 Sep; 90: 568-79.

                


                  Gordon ZN, McLeod DJ, Ching CB, Herz DB, Bates DG, Becknell B, Alpert SA. Uroepithelial thickening improves detection of vesicoureteral reflux in infants with prenatal hydronephrosis. J Pediatr Urol. 2016 Aug; 12: 257.e1-7.

                


                  Becknell B, Spencer JD. A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense. Int J Mol Sci. 2016 Mar 22; 17: 423.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2013

Board Certifications

Pediatric Nephrology Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2013

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Medical School

Ohio State University College of Medicine

Date Completed: 06/08/2008

Contact Information

Pediatrics

Call us at: (614) 722-4360

Fax us at: (614) 722-6482

                    Nephrology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-4360

Fax us at: (614) 722-6482

PediatricsNephrology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Michael Brian Becknell

Contact Information

  • Call us at:
  • (614) 722-4360
  • Fax us at:
  • (614) 722-6482
  • PediatricsNephrology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Michael Brian Becknell

Biography

M. Brian Becknell, MD, PhD, is a pediatric nephrologist at Nationwide Children’s and principal investigator for the Kidney and Urinary Tract Center. He is also an assistant professor of pediatrics for The Ohio State University College of Medicine, where he received his medical degree. Dr. Becknell completed his residency and pediatric nephrology fellowship at Nationwide Children’s. His clinical interests include pyelonephritis and congenital obstructive nephropathy. Dr. Becknell’s research interests include understanding the mechanisms responsible for deterioration of kidney function in children with congenital obstructive nephropathy.

Biography

M. Brian Becknell, MD, PhD, is a pediatric nephrologist at Nationwide Children’s and principal investigator for the Kidney and Urinary Tract Center. He is also an assistant professor of pediatrics for The Ohio State University College of Medicine, where he received his medical degree. Dr. Becknell completed his residency and pediatric nephrology fellowship at Nationwide Children’s. His clinical interests include pyelonephritis and congenital obstructive nephropathy. Dr. Becknell’s research interests include understanding the mechanisms responsible for deterioration of kidney function in children with congenital obstructive nephropathy.

Biography

M. Brian Becknell, MD, PhD, is a pediatric nephrologist at Nationwide Children’s and principal investigator for the Kidney and Urinary Tract Center. He is also an assistant professor of pediatrics for The Ohio State University College of Medicine, where he received his medical degree. Dr. Becknell completed his residency and pediatric nephrology fellowship at Nationwide Children’s. His clinical interests include pyelonephritis and congenital obstructive nephropathy. Dr. Becknell’s research interests include understanding the mechanisms responsible for deterioration of kidney function in children with congenital obstructive nephropathy.

M. Brian Becknell, MD, PhD, is a pediatric nephrologist at Nationwide Children’s and principal investigator for the Kidney and Urinary Tract Center. He is also an assistant professor of pediatrics for The Ohio State University College of Medicine, where he received his medical degree. Dr. Becknell completed his residency and pediatric nephrology fellowship at Nationwide Children’s. His clinical interests include pyelonephritis and congenital obstructive nephropathy. Dr. Becknell’s research interests include understanding the mechanisms responsible for deterioration of kidney function in children with congenital obstructive nephropathy.

M. Brian Becknell, MD, PhD, is a pediatric nephrologist at Nationwide Children’s and principal investigator for the Kidney and Urinary Tract Center. He is also an assistant professor of pediatrics for The Ohio State University College of Medicine, where he received his medical degree. Dr. Becknell completed his residency and pediatric nephrology fellowship at Nationwide Children’s. His clinical interests include pyelonephritis and congenital obstructive nephropathy. Dr. Becknell’s research interests include understanding the mechanisms responsible for deterioration of kidney function in children with congenital obstructive nephropathy.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English German

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English German

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English German

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English German

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English German

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English German

  • Main Campus of Nationwide Children’s Hospital

  • English

  • German

Academic and Clinical Areas

Nephrology and Hypertension

Physician Team

Nephrology Fellowship

Faculty

Nephrology and Urology Research Affinity Group

Faculty

Kidney and Urinary Tract Center Team

Research Director

Becknell Lab

Principal Investigator

Primary Department

Pediatrics

Primary Section

Nephrology and Hypertension

Academic and Clinical Areas

Nephrology and Hypertension

Physician Team

Nephrology Fellowship

Faculty

Nephrology and Urology Research Affinity Group

Faculty

Kidney and Urinary Tract Center Team

Research Director

Becknell Lab

Principal Investigator

Primary Department

Pediatrics

Primary Section

Nephrology and Hypertension

Academic and Clinical Areas

Nephrology and Hypertension

Physician Team

Nephrology Fellowship

Faculty

Nephrology and Urology Research Affinity Group

Faculty

Kidney and Urinary Tract Center Team

Research Director

Becknell Lab

Principal Investigator

Primary Department

Pediatrics

Primary Section

Nephrology and Hypertension

Nephrology and Hypertension

Physician Team

Nephrology Fellowship

Faculty

Nephrology and Urology Research Affinity Group

Faculty

Kidney and Urinary Tract Center Team

Research Director

Becknell Lab

Principal Investigator

Primary Department

Pediatrics

Primary Section

Nephrology and Hypertension

  • Nephrology and Hypertension
  • Physician Team
  • Nephrology Fellowship
  • Faculty
  • Nephrology and Urology Research Affinity Group
  • Faculty
  • Kidney and Urinary Tract Center Team
  • Research Director
  • Becknell Lab
  • Principal Investigator
  • Primary Department
  • Pediatrics
  • Primary Section
  • Nephrology and Hypertension

Awards, Honors & Organizations

Kenney Award, Best Abstract Presentation by a Pediatric Fellow, Midwest Society for Pediatric Research, 2012 NIH Loan Repayment Program Award,, NIDDK, 2012 Travel Grant, Society for Pediatric Research, 2012 Resident Teaching Award, Department of Pediatrics, Ohio State University College of Medicine, 2011 Outstanding Resident Publication Award, Nationwide Children’s Hospital, 2011 NIH Loan Repayment Program Award, NIDDK, 2010 Resident Research Grant, American Academy of Pediatrics, 2010 Intramural Grant, Nationwide Children’s Hospital Research Institute, 2010 House Officer Research Award, Society for Pediatric Research, 2010 Invited Resident, Association of Medical School Pediatric Department Chairs (AMSPDC) Frontiers in Science, 2010 Invited Resident Travel Grant, American Society for Nephrology, 2009 Travel Grant, Pediatric Nephrology Seminar, University of Miami Leonard M. Miller School of Medicine, 2009 Medical Scientist Award, The Ohio State University College of Medicine, 2008 MD/PhD Leadership and Academic Achievement Scholarship, The Ohio State University College of Medicine, 2008 Outstanding Academic Merit Scholarship, The Ohio State University College of Medicine, 2008 Grant Morrow III, MD Award, Department of Pediatrics, The Ohio State University College of Medicine, 2008 Travel Award, American Society of Hematology, 2004 Dean’s Distinguished University Fellowship, The Ohio State University, Graduate School of Arts and Sciences, 1999 Bennett Fellowship, The Ohio State University College of Medicine, 1999 Medical Scientist Fellowship, The Ohio State University College of Medicine, 1999 National Science Foundation (NSF) Predoctoral Fellowship, 1998 Member, Alpha Omega Alpha, The Ohio State University College of Medicine, 2008 - Present Member, Landacre Society, The Ohio State University College of Medicine, 2007 - Present Member, Phi Beta Kappa, Kenyon College, 1997 - Present

Awards, Honors & Organizations

Kenney Award, Best Abstract Presentation by a Pediatric Fellow, Midwest Society for Pediatric Research, 2012 NIH Loan Repayment Program Award,, NIDDK, 2012 Travel Grant, Society for Pediatric Research, 2012 Resident Teaching Award, Department of Pediatrics, Ohio State University College of Medicine, 2011 Outstanding Resident Publication Award, Nationwide Children’s Hospital, 2011 NIH Loan Repayment Program Award, NIDDK, 2010 Resident Research Grant, American Academy of Pediatrics, 2010 Intramural Grant, Nationwide Children’s Hospital Research Institute, 2010 House Officer Research Award, Society for Pediatric Research, 2010 Invited Resident, Association of Medical School Pediatric Department Chairs (AMSPDC) Frontiers in Science, 2010 Invited Resident Travel Grant, American Society for Nephrology, 2009 Travel Grant, Pediatric Nephrology Seminar, University of Miami Leonard M. Miller School of Medicine, 2009 Medical Scientist Award, The Ohio State University College of Medicine, 2008 MD/PhD Leadership and Academic Achievement Scholarship, The Ohio State University College of Medicine, 2008 Outstanding Academic Merit Scholarship, The Ohio State University College of Medicine, 2008 Grant Morrow III, MD Award, Department of Pediatrics, The Ohio State University College of Medicine, 2008 Travel Award, American Society of Hematology, 2004 Dean’s Distinguished University Fellowship, The Ohio State University, Graduate School of Arts and Sciences, 1999 Bennett Fellowship, The Ohio State University College of Medicine, 1999 Medical Scientist Fellowship, The Ohio State University College of Medicine, 1999 National Science Foundation (NSF) Predoctoral Fellowship, 1998 Member, Alpha Omega Alpha, The Ohio State University College of Medicine, 2008 - Present Member, Landacre Society, The Ohio State University College of Medicine, 2007 - Present Member, Phi Beta Kappa, Kenyon College, 1997 - Present

Awards, Honors & Organizations

Kenney Award, Best Abstract Presentation by a Pediatric Fellow, Midwest Society for Pediatric Research, 2012 NIH Loan Repayment Program Award,, NIDDK, 2012 Travel Grant, Society for Pediatric Research, 2012 Resident Teaching Award, Department of Pediatrics, Ohio State University College of Medicine, 2011 Outstanding Resident Publication Award, Nationwide Children’s Hospital, 2011 NIH Loan Repayment Program Award, NIDDK, 2010 Resident Research Grant, American Academy of Pediatrics, 2010 Intramural Grant, Nationwide Children’s Hospital Research Institute, 2010 House Officer Research Award, Society for Pediatric Research, 2010 Invited Resident, Association of Medical School Pediatric Department Chairs (AMSPDC) Frontiers in Science, 2010 Invited Resident Travel Grant, American Society for Nephrology, 2009 Travel Grant, Pediatric Nephrology Seminar, University of Miami Leonard M. Miller School of Medicine, 2009 Medical Scientist Award, The Ohio State University College of Medicine, 2008 MD/PhD Leadership and Academic Achievement Scholarship, The Ohio State University College of Medicine, 2008 Outstanding Academic Merit Scholarship, The Ohio State University College of Medicine, 2008 Grant Morrow III, MD Award, Department of Pediatrics, The Ohio State University College of Medicine, 2008 Travel Award, American Society of Hematology, 2004 Dean’s Distinguished University Fellowship, The Ohio State University, Graduate School of Arts and Sciences, 1999 Bennett Fellowship, The Ohio State University College of Medicine, 1999 Medical Scientist Fellowship, The Ohio State University College of Medicine, 1999 National Science Foundation (NSF) Predoctoral Fellowship, 1998 Member, Alpha Omega Alpha, The Ohio State University College of Medicine, 2008 - Present Member, Landacre Society, The Ohio State University College of Medicine, 2007 - Present Member, Phi Beta Kappa, Kenyon College, 1997 - Present

Kenney Award, Best Abstract Presentation by a Pediatric Fellow, Midwest Society for Pediatric Research, 2012 NIH Loan Repayment Program Award,, NIDDK, 2012 Travel Grant, Society for Pediatric Research, 2012 Resident Teaching Award, Department of Pediatrics, Ohio State University College of Medicine, 2011 Outstanding Resident Publication Award, Nationwide Children’s Hospital, 2011 NIH Loan Repayment Program Award, NIDDK, 2010 Resident Research Grant, American Academy of Pediatrics, 2010 Intramural Grant, Nationwide Children’s Hospital Research Institute, 2010 House Officer Research Award, Society for Pediatric Research, 2010 Invited Resident, Association of Medical School Pediatric Department Chairs (AMSPDC) Frontiers in Science, 2010 Invited Resident Travel Grant, American Society for Nephrology, 2009 Travel Grant, Pediatric Nephrology Seminar, University of Miami Leonard M. Miller School of Medicine, 2009 Medical Scientist Award, The Ohio State University College of Medicine, 2008 MD/PhD Leadership and Academic Achievement Scholarship, The Ohio State University College of Medicine, 2008 Outstanding Academic Merit Scholarship, The Ohio State University College of Medicine, 2008 Grant Morrow III, MD Award, Department of Pediatrics, The Ohio State University College of Medicine, 2008 Travel Award, American Society of Hematology, 2004 Dean’s Distinguished University Fellowship, The Ohio State University, Graduate School of Arts and Sciences, 1999 Bennett Fellowship, The Ohio State University College of Medicine, 1999 Medical Scientist Fellowship, The Ohio State University College of Medicine, 1999 National Science Foundation (NSF) Predoctoral Fellowship, 1998 Member, Alpha Omega Alpha, The Ohio State University College of Medicine, 2008 - Present Member, Landacre Society, The Ohio State University College of Medicine, 2007 - Present Member, Phi Beta Kappa, Kenyon College, 1997 - Present

  • Kenney Award, Best Abstract Presentation by a Pediatric Fellow, Midwest Society for Pediatric Research, 2012
  • NIH Loan Repayment Program Award,, NIDDK, 2012
  • Travel Grant, Society for Pediatric Research, 2012
  • Resident Teaching Award, Department of Pediatrics, Ohio State University College of Medicine, 2011
  • Outstanding Resident Publication Award, Nationwide Children’s Hospital, 2011
  • NIH Loan Repayment Program Award, NIDDK, 2010
  • Resident Research Grant, American Academy of Pediatrics, 2010
  • Intramural Grant, Nationwide Children’s Hospital Research Institute, 2010
  • House Officer Research Award, Society for Pediatric Research, 2010
  • Invited Resident, Association of Medical School Pediatric Department Chairs (AMSPDC) Frontiers in Science, 2010
  • Invited Resident Travel Grant, American Society for Nephrology, 2009
  • Travel Grant, Pediatric Nephrology Seminar, University of Miami Leonard M. Miller School of Medicine, 2009
  • Medical Scientist Award, The Ohio State University College of Medicine, 2008
  • MD/PhD Leadership and Academic Achievement Scholarship, The Ohio State University College of Medicine, 2008
  • Outstanding Academic Merit Scholarship, The Ohio State University College of Medicine, 2008
  • Grant Morrow III, MD Award, Department of Pediatrics, The Ohio State University College of Medicine, 2008
  • Travel Award, American Society of Hematology, 2004
  • Dean’s Distinguished University Fellowship, The Ohio State University, Graduate School of Arts and Sciences, 1999
  • Bennett Fellowship, The Ohio State University College of Medicine, 1999
  • Medical Scientist Fellowship, The Ohio State University College of Medicine, 1999
  • National Science Foundation (NSF) Predoctoral Fellowship, 1998
  • Member, Alpha Omega Alpha, The Ohio State University College of Medicine, 2008 - Present
  • Member, Landacre Society, The Ohio State University College of Medicine, 2007 - Present
  • Member, Phi Beta Kappa, Kenyon College, 1997 - Present

Research

Lab(s)

Becknell Lab

Publications

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

                


                  Sebastião YV, Cooper JN, Becknell B, Ching CB, McLeod DJ. Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy. Pediatr Nephrol. 2021 Jan; 36: 111-118.

                


                  McLeod DJ, Sebastião YV, Ching CB, Greenberg JH, Furth SL, Becknell B. Longitudinal kidney injury biomarker trajectories in children with obstructive uropathy. Pediatr Nephrol. 2020 Oct; 35: 1907-1914.

                


                  Gupta S, Nicassio L, Junquera GY, Jackson AR, Fuchs M, McLeod D, Alpert S, Jayanthi VR, DaJusta D, McHugh KM, Becknell B, Ching CB. Impact of successful pediatric ureteropelvic junction obstruction surgery on urinary HIP/PAP and BD-1 levels. J Pediatr Urol. 2020 Oct; 16: 592.e1-592.e7.

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Ching C, Schwartz L, Spencer JD, Becknell B. Innate immunity and urinary tract infection. Pediatr Nephrol. 2020 Jul; 35: 1183-1192.

                


                  Millner RO, Preece J, Salvator A, McLeod DJ, Ching CB, Becknell B. Albuminuria in Pediatric Neurogenic Bladder: Identifying an Earlier Marker of Renal Disease. Urology. 2019 Nov; 133: 199-203.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Eichler T, Bender K, Murtha MJ, Schwartz L, Metheny J, Solden L, Jaggers RM, Bailey MT, Gupta S, Mosquera C, Ching C, La Perle K, Li B, Becknell B, Spencer JD. Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection. J Am Soc Nephrol. 2019 Aug; 30: 1385-1397.

                


                  Pottanat ND, Brook AC, Bartosova M, Cortado H, Gupta S, Li B, Jackson AR, Vonau M, Cohen S, Ferrara M, Ching CB, Spencer JD, Brauner A, Fraser DJ, Schmitt CP, Eberl M, Ayoob R, Becknell B. Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis. Sci Rep. 2019 May 23; 9: 7753.

                


                  McLeod DJ, Ching CB, Sebastião YV, Greenberg JH, Furth SL, McHugh KM, Becknell B. Common clinical markers predict end-stage renal disease in children with obstructive uropathy. Pediatr Nephrol. 2019 Mar; 34: 443-448.

                


                  Becknell B, Ching C, Spencer JD. The Responses of the Ribonuclease A Superfamily to Urinary Tract Infection. Front Immunol. 2019; 10: 2786.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Ching CB, Becknell B. Novel role for androgen signaling in pyelonephritis. Kidney Int. 2018 Sep; 94: 455-457.

                


                  Ching CB, Gupta S, Li B, Cortado H, Mayne N, Jackson AR, McHugh KM, Becknell B. Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection. Kidney Int. 2018 Jun; 93: 1320-1329.

                


                  Barua M, John R, Stella L, Li W, Roslin NM, Sharif B, Hack S, Lajoie-Starkell G, Schwaderer AL, Becknell B, Wuttke M, Köttgen A, Cattran D, Paterson AD, Pei Y. X-Linked Glomerulopathy Due to COL4A5 Founder Variant. Am J Kidney Dis. 2018 Mar; 71: 441-445.

                


                  Saxena V, Hains DS, Ketz J, Chanley M, Spencer JD, Becknell B, Pierce KR, Nelson RD, Purkerson JM, Schwartz GJ, Schwaderer AL. Cell specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct. Am J Physiol Renal Physiol. 2017 May 3;  ajprenal005122016.

                


                  Li B, Haridas B, Jackson AR, Cortado H, Mayne N, Kohnken R, Bolon B, McHugh KM, Schwaderer AL, Spencer JD, Ching CB, Hains DS, Justice SS, Partida-Sanchez S, Becknell B. Inflammation drives renal scarring in experimental pyelonephritis. Am J Physiol Renal Physiol. 2017 Jan 1; 312: F43-F53.

                


                  Schwaderer AL, Wang H, Kim S, Kline JM, Liang D, Brophy PD, McHugh KM, Tseng GC, Saxena V, Barr-Beare E, Pierce KR, Shaikh N, Manak JR, Cohen DM, Becknell B, Spencer JD, Baker PB, Yu CY, Hains DS. Polymorphisms in a-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux. J Am Soc Nephrol. 2016 Oct; 27: 3175-3186.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Mojica MF, Ouellette CP, Leber A, Becknell MB, Ardura MI, Perez F, Shimamura M, Bonomo RA, Aitken SL, Shelburne SA. Successful Treatment of Bloodstream Infection Due to Metallo-ß-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient. Antimicrob Agents Chemother. 2016 Sep; 60: 5130-4.

                


                  Eichler TE, Becknell B, Easterling RS, Ingraham SE, Cohen DM, Schwaderer AL, Hains DS, Li B, Cohen A, Metheny J, Tridandapani S, Spencer JD. Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract. Kidney Int. 2016 Sep; 90: 568-79.

                


                  Gordon ZN, McLeod DJ, Ching CB, Herz DB, Bates DG, Becknell B, Alpert SA. Uroepithelial thickening improves detection of vesicoureteral reflux in infants with prenatal hydronephrosis. J Pediatr Urol. 2016 Aug; 12: 257.e1-7.

                


                  Becknell B, Spencer JD. A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense. Int J Mol Sci. 2016 Mar 22; 17: 423.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

Research

Lab(s)

Becknell Lab

Publications

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

                


                  Sebastião YV, Cooper JN, Becknell B, Ching CB, McLeod DJ. Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy. Pediatr Nephrol. 2021 Jan; 36: 111-118.

                


                  McLeod DJ, Sebastião YV, Ching CB, Greenberg JH, Furth SL, Becknell B. Longitudinal kidney injury biomarker trajectories in children with obstructive uropathy. Pediatr Nephrol. 2020 Oct; 35: 1907-1914.

                


                  Gupta S, Nicassio L, Junquera GY, Jackson AR, Fuchs M, McLeod D, Alpert S, Jayanthi VR, DaJusta D, McHugh KM, Becknell B, Ching CB. Impact of successful pediatric ureteropelvic junction obstruction surgery on urinary HIP/PAP and BD-1 levels. J Pediatr Urol. 2020 Oct; 16: 592.e1-592.e7.

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Ching C, Schwartz L, Spencer JD, Becknell B. Innate immunity and urinary tract infection. Pediatr Nephrol. 2020 Jul; 35: 1183-1192.

                


                  Millner RO, Preece J, Salvator A, McLeod DJ, Ching CB, Becknell B. Albuminuria in Pediatric Neurogenic Bladder: Identifying an Earlier Marker of Renal Disease. Urology. 2019 Nov; 133: 199-203.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Eichler T, Bender K, Murtha MJ, Schwartz L, Metheny J, Solden L, Jaggers RM, Bailey MT, Gupta S, Mosquera C, Ching C, La Perle K, Li B, Becknell B, Spencer JD. Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection. J Am Soc Nephrol. 2019 Aug; 30: 1385-1397.

                


                  Pottanat ND, Brook AC, Bartosova M, Cortado H, Gupta S, Li B, Jackson AR, Vonau M, Cohen S, Ferrara M, Ching CB, Spencer JD, Brauner A, Fraser DJ, Schmitt CP, Eberl M, Ayoob R, Becknell B. Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis. Sci Rep. 2019 May 23; 9: 7753.

                


                  McLeod DJ, Ching CB, Sebastião YV, Greenberg JH, Furth SL, McHugh KM, Becknell B. Common clinical markers predict end-stage renal disease in children with obstructive uropathy. Pediatr Nephrol. 2019 Mar; 34: 443-448.

                


                  Becknell B, Ching C, Spencer JD. The Responses of the Ribonuclease A Superfamily to Urinary Tract Infection. Front Immunol. 2019; 10: 2786.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Ching CB, Becknell B. Novel role for androgen signaling in pyelonephritis. Kidney Int. 2018 Sep; 94: 455-457.

                


                  Ching CB, Gupta S, Li B, Cortado H, Mayne N, Jackson AR, McHugh KM, Becknell B. Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection. Kidney Int. 2018 Jun; 93: 1320-1329.

                


                  Barua M, John R, Stella L, Li W, Roslin NM, Sharif B, Hack S, Lajoie-Starkell G, Schwaderer AL, Becknell B, Wuttke M, Köttgen A, Cattran D, Paterson AD, Pei Y. X-Linked Glomerulopathy Due to COL4A5 Founder Variant. Am J Kidney Dis. 2018 Mar; 71: 441-445.

                


                  Saxena V, Hains DS, Ketz J, Chanley M, Spencer JD, Becknell B, Pierce KR, Nelson RD, Purkerson JM, Schwartz GJ, Schwaderer AL. Cell specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct. Am J Physiol Renal Physiol. 2017 May 3;  ajprenal005122016.

                


                  Li B, Haridas B, Jackson AR, Cortado H, Mayne N, Kohnken R, Bolon B, McHugh KM, Schwaderer AL, Spencer JD, Ching CB, Hains DS, Justice SS, Partida-Sanchez S, Becknell B. Inflammation drives renal scarring in experimental pyelonephritis. Am J Physiol Renal Physiol. 2017 Jan 1; 312: F43-F53.

                


                  Schwaderer AL, Wang H, Kim S, Kline JM, Liang D, Brophy PD, McHugh KM, Tseng GC, Saxena V, Barr-Beare E, Pierce KR, Shaikh N, Manak JR, Cohen DM, Becknell B, Spencer JD, Baker PB, Yu CY, Hains DS. Polymorphisms in a-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux. J Am Soc Nephrol. 2016 Oct; 27: 3175-3186.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Mojica MF, Ouellette CP, Leber A, Becknell MB, Ardura MI, Perez F, Shimamura M, Bonomo RA, Aitken SL, Shelburne SA. Successful Treatment of Bloodstream Infection Due to Metallo-ß-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient. Antimicrob Agents Chemother. 2016 Sep; 60: 5130-4.

                


                  Eichler TE, Becknell B, Easterling RS, Ingraham SE, Cohen DM, Schwaderer AL, Hains DS, Li B, Cohen A, Metheny J, Tridandapani S, Spencer JD. Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract. Kidney Int. 2016 Sep; 90: 568-79.

                


                  Gordon ZN, McLeod DJ, Ching CB, Herz DB, Bates DG, Becknell B, Alpert SA. Uroepithelial thickening improves detection of vesicoureteral reflux in infants with prenatal hydronephrosis. J Pediatr Urol. 2016 Aug; 12: 257.e1-7.

                


                  Becknell B, Spencer JD. A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense. Int J Mol Sci. 2016 Mar 22; 17: 423.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

Research

Lab(s)

Becknell Lab

Publications

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

                


                  Sebastião YV, Cooper JN, Becknell B, Ching CB, McLeod DJ. Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy. Pediatr Nephrol. 2021 Jan; 36: 111-118.

                


                  McLeod DJ, Sebastião YV, Ching CB, Greenberg JH, Furth SL, Becknell B. Longitudinal kidney injury biomarker trajectories in children with obstructive uropathy. Pediatr Nephrol. 2020 Oct; 35: 1907-1914.

                


                  Gupta S, Nicassio L, Junquera GY, Jackson AR, Fuchs M, McLeod D, Alpert S, Jayanthi VR, DaJusta D, McHugh KM, Becknell B, Ching CB. Impact of successful pediatric ureteropelvic junction obstruction surgery on urinary HIP/PAP and BD-1 levels. J Pediatr Urol. 2020 Oct; 16: 592.e1-592.e7.

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Ching C, Schwartz L, Spencer JD, Becknell B. Innate immunity and urinary tract infection. Pediatr Nephrol. 2020 Jul; 35: 1183-1192.

                


                  Millner RO, Preece J, Salvator A, McLeod DJ, Ching CB, Becknell B. Albuminuria in Pediatric Neurogenic Bladder: Identifying an Earlier Marker of Renal Disease. Urology. 2019 Nov; 133: 199-203.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Eichler T, Bender K, Murtha MJ, Schwartz L, Metheny J, Solden L, Jaggers RM, Bailey MT, Gupta S, Mosquera C, Ching C, La Perle K, Li B, Becknell B, Spencer JD. Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection. J Am Soc Nephrol. 2019 Aug; 30: 1385-1397.

                


                  Pottanat ND, Brook AC, Bartosova M, Cortado H, Gupta S, Li B, Jackson AR, Vonau M, Cohen S, Ferrara M, Ching CB, Spencer JD, Brauner A, Fraser DJ, Schmitt CP, Eberl M, Ayoob R, Becknell B. Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis. Sci Rep. 2019 May 23; 9: 7753.

                


                  McLeod DJ, Ching CB, Sebastião YV, Greenberg JH, Furth SL, McHugh KM, Becknell B. Common clinical markers predict end-stage renal disease in children with obstructive uropathy. Pediatr Nephrol. 2019 Mar; 34: 443-448.

                


                  Becknell B, Ching C, Spencer JD. The Responses of the Ribonuclease A Superfamily to Urinary Tract Infection. Front Immunol. 2019; 10: 2786.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Ching CB, Becknell B. Novel role for androgen signaling in pyelonephritis. Kidney Int. 2018 Sep; 94: 455-457.

                


                  Ching CB, Gupta S, Li B, Cortado H, Mayne N, Jackson AR, McHugh KM, Becknell B. Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection. Kidney Int. 2018 Jun; 93: 1320-1329.

                


                  Barua M, John R, Stella L, Li W, Roslin NM, Sharif B, Hack S, Lajoie-Starkell G, Schwaderer AL, Becknell B, Wuttke M, Köttgen A, Cattran D, Paterson AD, Pei Y. X-Linked Glomerulopathy Due to COL4A5 Founder Variant. Am J Kidney Dis. 2018 Mar; 71: 441-445.

                


                  Saxena V, Hains DS, Ketz J, Chanley M, Spencer JD, Becknell B, Pierce KR, Nelson RD, Purkerson JM, Schwartz GJ, Schwaderer AL. Cell specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct. Am J Physiol Renal Physiol. 2017 May 3;  ajprenal005122016.

                


                  Li B, Haridas B, Jackson AR, Cortado H, Mayne N, Kohnken R, Bolon B, McHugh KM, Schwaderer AL, Spencer JD, Ching CB, Hains DS, Justice SS, Partida-Sanchez S, Becknell B. Inflammation drives renal scarring in experimental pyelonephritis. Am J Physiol Renal Physiol. 2017 Jan 1; 312: F43-F53.

                


                  Schwaderer AL, Wang H, Kim S, Kline JM, Liang D, Brophy PD, McHugh KM, Tseng GC, Saxena V, Barr-Beare E, Pierce KR, Shaikh N, Manak JR, Cohen DM, Becknell B, Spencer JD, Baker PB, Yu CY, Hains DS. Polymorphisms in a-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux. J Am Soc Nephrol. 2016 Oct; 27: 3175-3186.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Mojica MF, Ouellette CP, Leber A, Becknell MB, Ardura MI, Perez F, Shimamura M, Bonomo RA, Aitken SL, Shelburne SA. Successful Treatment of Bloodstream Infection Due to Metallo-ß-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient. Antimicrob Agents Chemother. 2016 Sep; 60: 5130-4.

                


                  Eichler TE, Becknell B, Easterling RS, Ingraham SE, Cohen DM, Schwaderer AL, Hains DS, Li B, Cohen A, Metheny J, Tridandapani S, Spencer JD. Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract. Kidney Int. 2016 Sep; 90: 568-79.

                


                  Gordon ZN, McLeod DJ, Ching CB, Herz DB, Bates DG, Becknell B, Alpert SA. Uroepithelial thickening improves detection of vesicoureteral reflux in infants with prenatal hydronephrosis. J Pediatr Urol. 2016 Aug; 12: 257.e1-7.

                


                  Becknell B, Spencer JD. A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense. Int J Mol Sci. 2016 Mar 22; 17: 423.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

Lab(s)

Becknell Lab

Publications

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

                


                  Sebastião YV, Cooper JN, Becknell B, Ching CB, McLeod DJ. Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy. Pediatr Nephrol. 2021 Jan; 36: 111-118.

                


                  McLeod DJ, Sebastião YV, Ching CB, Greenberg JH, Furth SL, Becknell B. Longitudinal kidney injury biomarker trajectories in children with obstructive uropathy. Pediatr Nephrol. 2020 Oct; 35: 1907-1914.

                


                  Gupta S, Nicassio L, Junquera GY, Jackson AR, Fuchs M, McLeod D, Alpert S, Jayanthi VR, DaJusta D, McHugh KM, Becknell B, Ching CB. Impact of successful pediatric ureteropelvic junction obstruction surgery on urinary HIP/PAP and BD-1 levels. J Pediatr Urol. 2020 Oct; 16: 592.e1-592.e7.

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Ching C, Schwartz L, Spencer JD, Becknell B. Innate immunity and urinary tract infection. Pediatr Nephrol. 2020 Jul; 35: 1183-1192.

                


                  Millner RO, Preece J, Salvator A, McLeod DJ, Ching CB, Becknell B. Albuminuria in Pediatric Neurogenic Bladder: Identifying an Earlier Marker of Renal Disease. Urology. 2019 Nov; 133: 199-203.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Eichler T, Bender K, Murtha MJ, Schwartz L, Metheny J, Solden L, Jaggers RM, Bailey MT, Gupta S, Mosquera C, Ching C, La Perle K, Li B, Becknell B, Spencer JD. Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection. J Am Soc Nephrol. 2019 Aug; 30: 1385-1397.

                


                  Pottanat ND, Brook AC, Bartosova M, Cortado H, Gupta S, Li B, Jackson AR, Vonau M, Cohen S, Ferrara M, Ching CB, Spencer JD, Brauner A, Fraser DJ, Schmitt CP, Eberl M, Ayoob R, Becknell B. Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis. Sci Rep. 2019 May 23; 9: 7753.

                


                  McLeod DJ, Ching CB, Sebastião YV, Greenberg JH, Furth SL, McHugh KM, Becknell B. Common clinical markers predict end-stage renal disease in children with obstructive uropathy. Pediatr Nephrol. 2019 Mar; 34: 443-448.

                


                  Becknell B, Ching C, Spencer JD. The Responses of the Ribonuclease A Superfamily to Urinary Tract Infection. Front Immunol. 2019; 10: 2786.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Ching CB, Becknell B. Novel role for androgen signaling in pyelonephritis. Kidney Int. 2018 Sep; 94: 455-457.

                


                  Ching CB, Gupta S, Li B, Cortado H, Mayne N, Jackson AR, McHugh KM, Becknell B. Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection. Kidney Int. 2018 Jun; 93: 1320-1329.

                


                  Barua M, John R, Stella L, Li W, Roslin NM, Sharif B, Hack S, Lajoie-Starkell G, Schwaderer AL, Becknell B, Wuttke M, Köttgen A, Cattran D, Paterson AD, Pei Y. X-Linked Glomerulopathy Due to COL4A5 Founder Variant. Am J Kidney Dis. 2018 Mar; 71: 441-445.

                


                  Saxena V, Hains DS, Ketz J, Chanley M, Spencer JD, Becknell B, Pierce KR, Nelson RD, Purkerson JM, Schwartz GJ, Schwaderer AL. Cell specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct. Am J Physiol Renal Physiol. 2017 May 3;  ajprenal005122016.

                


                  Li B, Haridas B, Jackson AR, Cortado H, Mayne N, Kohnken R, Bolon B, McHugh KM, Schwaderer AL, Spencer JD, Ching CB, Hains DS, Justice SS, Partida-Sanchez S, Becknell B. Inflammation drives renal scarring in experimental pyelonephritis. Am J Physiol Renal Physiol. 2017 Jan 1; 312: F43-F53.

                


                  Schwaderer AL, Wang H, Kim S, Kline JM, Liang D, Brophy PD, McHugh KM, Tseng GC, Saxena V, Barr-Beare E, Pierce KR, Shaikh N, Manak JR, Cohen DM, Becknell B, Spencer JD, Baker PB, Yu CY, Hains DS. Polymorphisms in a-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux. J Am Soc Nephrol. 2016 Oct; 27: 3175-3186.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Mojica MF, Ouellette CP, Leber A, Becknell MB, Ardura MI, Perez F, Shimamura M, Bonomo RA, Aitken SL, Shelburne SA. Successful Treatment of Bloodstream Infection Due to Metallo-ß-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient. Antimicrob Agents Chemother. 2016 Sep; 60: 5130-4.

                


                  Eichler TE, Becknell B, Easterling RS, Ingraham SE, Cohen DM, Schwaderer AL, Hains DS, Li B, Cohen A, Metheny J, Tridandapani S, Spencer JD. Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract. Kidney Int. 2016 Sep; 90: 568-79.

                


                  Gordon ZN, McLeod DJ, Ching CB, Herz DB, Bates DG, Becknell B, Alpert SA. Uroepithelial thickening improves detection of vesicoureteral reflux in infants with prenatal hydronephrosis. J Pediatr Urol. 2016 Aug; 12: 257.e1-7.

                


                  Becknell B, Spencer JD. A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense. Int J Mol Sci. 2016 Mar 22; 17: 423.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

Lab(s)

Becknell Lab

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

                


                  Sebastião YV, Cooper JN, Becknell B, Ching CB, McLeod DJ. Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy. Pediatr Nephrol. 2021 Jan; 36: 111-118.

                


                  McLeod DJ, Sebastião YV, Ching CB, Greenberg JH, Furth SL, Becknell B. Longitudinal kidney injury biomarker trajectories in children with obstructive uropathy. Pediatr Nephrol. 2020 Oct; 35: 1907-1914.

                


                  Gupta S, Nicassio L, Junquera GY, Jackson AR, Fuchs M, McLeod D, Alpert S, Jayanthi VR, DaJusta D, McHugh KM, Becknell B, Ching CB. Impact of successful pediatric ureteropelvic junction obstruction surgery on urinary HIP/PAP and BD-1 levels. J Pediatr Urol. 2020 Oct; 16: 592.e1-592.e7.

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Ching C, Schwartz L, Spencer JD, Becknell B. Innate immunity and urinary tract infection. Pediatr Nephrol. 2020 Jul; 35: 1183-1192.

                


                  Millner RO, Preece J, Salvator A, McLeod DJ, Ching CB, Becknell B. Albuminuria in Pediatric Neurogenic Bladder: Identifying an Earlier Marker of Renal Disease. Urology. 2019 Nov; 133: 199-203.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Eichler T, Bender K, Murtha MJ, Schwartz L, Metheny J, Solden L, Jaggers RM, Bailey MT, Gupta S, Mosquera C, Ching C, La Perle K, Li B, Becknell B, Spencer JD. Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection. J Am Soc Nephrol. 2019 Aug; 30: 1385-1397.

                


                  Pottanat ND, Brook AC, Bartosova M, Cortado H, Gupta S, Li B, Jackson AR, Vonau M, Cohen S, Ferrara M, Ching CB, Spencer JD, Brauner A, Fraser DJ, Schmitt CP, Eberl M, Ayoob R, Becknell B. Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis. Sci Rep. 2019 May 23; 9: 7753.

                


                  McLeod DJ, Ching CB, Sebastião YV, Greenberg JH, Furth SL, McHugh KM, Becknell B. Common clinical markers predict end-stage renal disease in children with obstructive uropathy. Pediatr Nephrol. 2019 Mar; 34: 443-448.

                


                  Becknell B, Ching C, Spencer JD. The Responses of the Ribonuclease A Superfamily to Urinary Tract Infection. Front Immunol. 2019; 10: 2786.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Ching CB, Becknell B. Novel role for androgen signaling in pyelonephritis. Kidney Int. 2018 Sep; 94: 455-457.

                


                  Ching CB, Gupta S, Li B, Cortado H, Mayne N, Jackson AR, McHugh KM, Becknell B. Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection. Kidney Int. 2018 Jun; 93: 1320-1329.

                


                  Barua M, John R, Stella L, Li W, Roslin NM, Sharif B, Hack S, Lajoie-Starkell G, Schwaderer AL, Becknell B, Wuttke M, Köttgen A, Cattran D, Paterson AD, Pei Y. X-Linked Glomerulopathy Due to COL4A5 Founder Variant. Am J Kidney Dis. 2018 Mar; 71: 441-445.

                


                  Saxena V, Hains DS, Ketz J, Chanley M, Spencer JD, Becknell B, Pierce KR, Nelson RD, Purkerson JM, Schwartz GJ, Schwaderer AL. Cell specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct. Am J Physiol Renal Physiol. 2017 May 3;  ajprenal005122016.

                


                  Li B, Haridas B, Jackson AR, Cortado H, Mayne N, Kohnken R, Bolon B, McHugh KM, Schwaderer AL, Spencer JD, Ching CB, Hains DS, Justice SS, Partida-Sanchez S, Becknell B. Inflammation drives renal scarring in experimental pyelonephritis. Am J Physiol Renal Physiol. 2017 Jan 1; 312: F43-F53.

                


                  Schwaderer AL, Wang H, Kim S, Kline JM, Liang D, Brophy PD, McHugh KM, Tseng GC, Saxena V, Barr-Beare E, Pierce KR, Shaikh N, Manak JR, Cohen DM, Becknell B, Spencer JD, Baker PB, Yu CY, Hains DS. Polymorphisms in a-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux. J Am Soc Nephrol. 2016 Oct; 27: 3175-3186.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Mojica MF, Ouellette CP, Leber A, Becknell MB, Ardura MI, Perez F, Shimamura M, Bonomo RA, Aitken SL, Shelburne SA. Successful Treatment of Bloodstream Infection Due to Metallo-ß-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient. Antimicrob Agents Chemother. 2016 Sep; 60: 5130-4.

                


                  Eichler TE, Becknell B, Easterling RS, Ingraham SE, Cohen DM, Schwaderer AL, Hains DS, Li B, Cohen A, Metheny J, Tridandapani S, Spencer JD. Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract. Kidney Int. 2016 Sep; 90: 568-79.

                


                  Gordon ZN, McLeod DJ, Ching CB, Herz DB, Bates DG, Becknell B, Alpert SA. Uroepithelial thickening improves detection of vesicoureteral reflux in infants with prenatal hydronephrosis. J Pediatr Urol. 2016 Aug; 12: 257.e1-7.

                


                  Becknell B, Spencer JD. A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense. Int J Mol Sci. 2016 Mar 22; 17: 423.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

Lab(s)

Becknell Lab

  • Becknell Lab

  • Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;

  • Ruiz-Rosado JD, Robledo-Avila F, Cortado H, Rangel-Moreno J, Justice SS, Yang C, Spencer JD, Becknell B, Partida-Sanchez S. Neutrophil-Macrophage Imbalance Drives the Development of Renal Scarring during Experimental Pyelonephritis. J Am Soc Nephrol. 2021 Jan; 32: 69-85.

  • Sebastião YV, Cooper JN, Becknell B, Ching CB, McLeod DJ. Prediction of kidney failure in children with chronic kidney disease and obstructive uropathy. Pediatr Nephrol. 2021 Jan; 36: 111-118.

  • McLeod DJ, Sebastião YV, Ching CB, Greenberg JH, Furth SL, Becknell B. Longitudinal kidney injury biomarker trajectories in children with obstructive uropathy. Pediatr Nephrol. 2020 Oct; 35: 1907-1914.

  • Gupta S, Nicassio L, Junquera GY, Jackson AR, Fuchs M, McLeod D, Alpert S, Jayanthi VR, DaJusta D, McHugh KM, Becknell B, Ching CB. Impact of successful pediatric ureteropelvic junction obstruction surgery on urinary HIP/PAP and BD-1 levels. J Pediatr Urol. 2020 Oct; 16: 592.e1-592.e7.

  • Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

  • Ching C, Schwartz L, Spencer JD, Becknell B. Innate immunity and urinary tract infection. Pediatr Nephrol. 2020 Jul; 35: 1183-1192.

  • Millner RO, Preece J, Salvator A, McLeod DJ, Ching CB, Becknell B. Albuminuria in Pediatric Neurogenic Bladder: Identifying an Earlier Marker of Renal Disease. Urology. 2019 Nov; 133: 199-203.

  • Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

  • Eichler T, Bender K, Murtha MJ, Schwartz L, Metheny J, Solden L, Jaggers RM, Bailey MT, Gupta S, Mosquera C, Ching C, La Perle K, Li B, Becknell B, Spencer JD. Ribonuclease 7 Shields the Kidney and Bladder from Invasive Uropathogenic Escherichia coli Infection. J Am Soc Nephrol. 2019 Aug; 30: 1385-1397.

  • Pottanat ND, Brook AC, Bartosova M, Cortado H, Gupta S, Li B, Jackson AR, Vonau M, Cohen S, Ferrara M, Ching CB, Spencer JD, Brauner A, Fraser DJ, Schmitt CP, Eberl M, Ayoob R, Becknell B. Analysis of the Ribonuclease A Superfamily of Antimicrobial Peptides in Patients Undergoing Chronic Peritoneal Dialysis. Sci Rep. 2019 May 23; 9: 7753.

  • McLeod DJ, Ching CB, Sebastião YV, Greenberg JH, Furth SL, McHugh KM, Becknell B. Common clinical markers predict end-stage renal disease in children with obstructive uropathy. Pediatr Nephrol. 2019 Mar; 34: 443-448.

  • Becknell B, Ching C, Spencer JD. The Responses of the Ribonuclease A Superfamily to Urinary Tract Infection. Front Immunol. 2019; 10: 2786.

  • Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

  • Ching CB, Becknell B. Novel role for androgen signaling in pyelonephritis. Kidney Int. 2018 Sep; 94: 455-457.

  • Ching CB, Gupta S, Li B, Cortado H, Mayne N, Jackson AR, McHugh KM, Becknell B. Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection. Kidney Int. 2018 Jun; 93: 1320-1329.

  • Barua M, John R, Stella L, Li W, Roslin NM, Sharif B, Hack S, Lajoie-Starkell G, Schwaderer AL, Becknell B, Wuttke M, Köttgen A, Cattran D, Paterson AD, Pei Y. X-Linked Glomerulopathy Due to COL4A5 Founder Variant. Am J Kidney Dis. 2018 Mar; 71: 441-445.

  • Saxena V, Hains DS, Ketz J, Chanley M, Spencer JD, Becknell B, Pierce KR, Nelson RD, Purkerson JM, Schwartz GJ, Schwaderer AL. Cell specific qRT-PCR of renal epithelial cells reveals a novel innate immune signature in murine collecting duct. Am J Physiol Renal Physiol. 2017 May 3; ajprenal005122016.

  • Li B, Haridas B, Jackson AR, Cortado H, Mayne N, Kohnken R, Bolon B, McHugh KM, Schwaderer AL, Spencer JD, Ching CB, Hains DS, Justice SS, Partida-Sanchez S, Becknell B. Inflammation drives renal scarring in experimental pyelonephritis. Am J Physiol Renal Physiol. 2017 Jan 1; 312: F43-F53.

  • Schwaderer AL, Wang H, Kim S, Kline JM, Liang D, Brophy PD, McHugh KM, Tseng GC, Saxena V, Barr-Beare E, Pierce KR, Shaikh N, Manak JR, Cohen DM, Becknell B, Spencer JD, Baker PB, Yu CY, Hains DS. Polymorphisms in a-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux. J Am Soc Nephrol. 2016 Oct; 27: 3175-3186.

  • Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

  • Mojica MF, Ouellette CP, Leber A, Becknell MB, Ardura MI, Perez F, Shimamura M, Bonomo RA, Aitken SL, Shelburne SA. Successful Treatment of Bloodstream Infection Due to Metallo-ß-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient. Antimicrob Agents Chemother. 2016 Sep; 60: 5130-4.

  • Eichler TE, Becknell B, Easterling RS, Ingraham SE, Cohen DM, Schwaderer AL, Hains DS, Li B, Cohen A, Metheny J, Tridandapani S, Spencer JD. Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract. Kidney Int. 2016 Sep; 90: 568-79.

  • Gordon ZN, McLeod DJ, Ching CB, Herz DB, Bates DG, Becknell B, Alpert SA. Uroepithelial thickening improves detection of vesicoureteral reflux in infants with prenatal hydronephrosis. J Pediatr Urol. 2016 Aug; 12: 257.e1-7.

  • Becknell B, Spencer JD. A Review of Ribonuclease 7’s Structure, Regulation, and Contributions to Host Defense. Int J Mol Sci. 2016 Mar 22; 17: 423.

  • Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2013

Board Certifications

Pediatric Nephrology Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2013

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Medical School

Ohio State University College of Medicine

Date Completed: 06/08/2008

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2013

Board Certifications

Pediatric Nephrology Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2013

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Medical School

Ohio State University College of Medicine

Date Completed: 06/08/2008

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2013

Board Certifications

Pediatric Nephrology Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2013

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Medical School

Ohio State University College of Medicine

Date Completed: 06/08/2008

Date of Appointment at Nationwide Children’s Hospital: 07/01/2013

Board Certifications

Pediatric Nephrology Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2013

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Medical School

Ohio State University College of Medicine

Date Completed: 06/08/2008

Date of Appointment at Nationwide Children’s Hospital: 07/01/2013

Board Certifications

Pediatric Nephrology Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2013

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Medical School

Ohio State University College of Medicine

Date Completed: 06/08/2008

  • Pediatric Nephrology
  • Pediatrics

Contact Information

Pediatrics

Call us at: (614) 722-4360

Fax us at: (614) 722-6482

                    Nephrology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pediatrics

Call us at: (614) 722-4360

Fax us at: (614) 722-6482

                    Nephrology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pediatrics

Call us at: (614) 722-4360

Fax us at: (614) 722-6482

                    Nephrology700 Children's DrColumbus, OH 43205 (map)

Pediatrics

Call us at: (614) 722-4360

Fax us at: (614) 722-6482

                    Nephrology700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-4360

Fax us at: (614) 722-6482

                    Nephrology700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-4360

Fax us at: (614) 722-6482

                    Nephrology700 Children's DrColumbus, OH 43205 (map)
  • Call us at:
  • (614) 722-4360
  • Fax us at:
  • (614) 722-6482
  • Nephrology700 Children’s DrColumbus, OH 43205 (map)