Contact Information

Call us at: (614)355-6715

Center for Perinatal ResearchAbigail Wexner Research Institute, Center for Perinatal Research575 Children’s Crossroads, Research Building III, 6th FloorColumbus, 43215 (map)

Learn more about Lynette Kay Rogers

Biography

        Lynette K. Rogers, Ph.D. is a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. She is an Associate Professor at The Ohio State University College of Medicine. Dr. Rogers NIH-funded research focuses on lung injury and growth deficits in preterm infants.The ultimate goal of the Rogers lab is to better understand the consequences of premature birth and strive to develop efficacious treatments that would decrease morbidities in prematurely born infants. Many preterm births are a result of maternal inflammation and once born, the infant often requires oxygen therapy for survival. The combination of inflammatory stimuli results in a much more severe pathophysiology with more critical and long lasting morbidities. Our studies have identified several epigenetic markers that are affected by one or both of these adverse conditions and may be linked to further disease development. These include microRNAs, upregulation of methylation enzymes, and methylation of key genes. These markers have been identified in infants diagnosed with Bronchopulmonary dysplasia (BPD) and in our mouse model of combined inflammatory exposures. We are working to better understand the mechanisms driving these alterations, how they affect the morbidities observed, and to identify pathways that can be targeted for interventions.

Academic and Clinical Areas

Center for Perinatal Research

Interim Director

Neonatology

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Center for Perinatal Research

Awards, Honors & Organizations

Member, Perinatal Research Society, 2013 - Present Member, Sigma Xi, 2012 - Present Member, American Physiological Society, 2011 - Present Member, American Society for Nutrition, 2011 - Present Member, American Heart Association, 2011 - Present Member, American Thoracic Society, 2006 - Present Member, Society of Toxicology, 2003 - Present

Research

Lab(s)

Center for Perinatal Research

The ultimate goal of Rogers’ lab is to identify the causes of premature birth, help design treatments that would prevent prematurity, and strive to help develop efficacious treatments that would decrease morbidities in prematurely born infants. The research efforts in the lab are two fold. First, they are working to identify biomarkers early in the life of a premature infant that would predict outcomes and development of diseases and better understand the mechanisms involved in these disease processes. They use a broad scope of analytical techniques to identify alterations in proteins and lipids in both animal models of premature birth as well as human studies. Secondly, our animal models focus on inflammation resolution. Inflammation is a large component of diseases associated with prematurity, specifically those that involve the lung. Impaired inflammatory resolution may, in part, be responsible for the progression and chronic state of lung diseases in the premature infant. They are working to develop interventions that would improve inflammatory resolution in a newborn mouse model.

View My Publications

Publications

                  Fernandes J, Dunigan-Russell K, Zhong H, Lin V, Silverberg M, Moore SB, Tran V, Jones DP, Vitiello PF, Rogers LK, Tipple TE. Transcriptomic-Metabolomic Profiling in Mouse Lung Tissues Reveals Sex- and Strain-Based Differences. Metabolites. 2022 Sep 30; 12: 

                


                  Boone KM, Klebanoff MA, Rogers LK, Rausch J, Coury DL, Keim SA. Effects of Omega-3-6-9 fatty acid supplementation on behavior and sleep in preterm toddlers with autism symptomatology: Secondary analysis of a randomized clinical trial. Early Hum Dev. 2022 May 19; 169: 105588.

                


                  Adams JM, Valentine CJ, Karns RA, Rogers LK, Murase M, Fowler GN, Nommsen-Rivers LA. DHA supplementation attenuates inflammation-associated gene expression in the mammary gland of lactating mothers who deliver preterm. J Nutr. 2022 Feb 24;  

                


                  Keim SA, Jude A, Smith K, Khan AQ, Coury DL, Rausch J, Udaipuria S, Norris M, Bartram LR, Narayanan AR, Rogers LK. Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder. J Autism Dev Disord. 2022 Jan 11;  

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Rogers LK, Slaughter JL. Editorial: Developmental origins of health and disease: Impact of preterm birth. Front Pediatr. 2022; 10: 1120208.

                


                  Parad RB, Breeze JL, Terrin N, Rogers LK, Salafia CM, Greenough A, Davis JM. Differences in clinical and laboratory biomarkers for short and long-term respiratory outcomes in preterm neonates. Pediatr Pulmonol. 2021 Dec; 56: 3847-3856.

                


                  Valentine CJ, Khan AQ, Brown AR, Sands SA, Defranco EA, Gajewski BJ, Carlson SE, Reber KM, Rogers LK. Higher-Dose DHA Supplementation Modulates Immune Responses in Pregnancy and Is Associated with Decreased Preterm Birth. Nutrients. 2021 Nov 26; 13: 

                


                  Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 

                


                  Boone KM, Pattison K, Pelak G, Sheppard KW, Rausch J, Yeates KO, Nelin MA, Klebanoff MA, Turner AN, Rogers LK, Keim SA. Docosahexaenoic and arachidonic acid supplementation at 1 year has mixed effects on development and behaviour at age 2 for preterm children. Acta Paediatr. 2021 Jul; 110: 2082-2083.

                


                  Carlson SE, Gajewski BJ, Valentine CJ, Kerling EH, Weiner CP, Cackovic M, Buhimschi CS, Rogers LK, Sands SA, Brown AR, Mudaranthakam DP, Crawford SA, DeFranco EA. Higher dose docosahexaenoic acid supplementation during pregnancy and early preterm birth: A randomised, double-blind, adaptive-design superiority trial. EClinicalMedicine. 2021 Jun; 36: 100905.

                


                  Wall SB, Li R, Butler B, Burg AR, Tse HM, Larson-Casey JL, Carter AB, Wright CJ, Rogers LK, Tipple TE. Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages. Antioxidants (Basel). 2021 Apr 21; 10: 

                


                  Pavlek LR, Vudatala S, Bartlett CW, Buhimschi IA, Buhimschi CS, Rogers LK. MiR-29b is associated with perinatal inflammation in extremely preterm infants. Pediatr Res. 2021 Mar; 89: 889-893.

                


                  Robbins ME, Cho HY, Hansen JM, Luchsinger JR, Locy ML, Velten M, Kleeberger SR, Rogers LK, Tipple TE. Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice. Redox Biol. 2021 Jan; 38: 101797.

                


                  Sugar SS, Heyob KM, Cheng X, Lee RJ, Rogers LK. Perinatal inflammation alters histone 3 and histone 4 methylation patterns: Effects of MiR-29b supplementation. Redox Biol. 2021 Jan; 38: 101783.

                


                  Buhimschi CS, Bahtiyar MO, Zhao G, Abdelghany O, Schneider L, Razeq SA, Dulay AT, Lipkind HS, Mieth S, Rogers L, Bhandari V, Buhimschi IA. Antenatal N-acetylcysteine to improve outcomes of premature infants with intra-amniotic infection and inflammation (Triple I): randomized clinical trial. Pediatr Res. 2021 Jan; 89: 175-184.

                


                  Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  

                


                  Valentine CJ, Dingess KA, Kleiman J, Morrow AL, Rogers LK. A Randomized Trial of Maternal Docosahexaenoic Acid Supplementation to Reduce Inflammation in Extremely Preterm Infants. J Pediatr Gastroenterol Nutr. 2019 Apr 29;  

                


                  Keim SA, Rogers LK, Klebanoff MA. Supplementing Essential Polyunsaturated Fatty Acids-A Matter of Respecting Fetal Development-Reply. JAMA Pediatr. 2019 Mar 25;  

                


                  Kopp BT, Thompson R, Kim J, Konstan R, Diaz A, Smith B, Shrestha C, Rogers LK, Hayes D Jr, Tumin D, Woodley FW, Ramilo O, Sanders DB, Groner JA, Mejias A. Secondhand smoke alters arachidonic acid metabolism and inflammation in infants and children with cystic fibrosis. Thorax. 2019 Mar; 74: 237-246.

                


                  Wall SB, Wood R, Dunigan K, Li Q, Li R, Rogers LK, Tipple TE. Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia. Oxid Med Cell Longev. 2019; 2019: 7945983.

                


                  Ali M, Heyob K, Tipple TE, Pryhuber GS, Rogers LK. Alterations in VASP phosphorylation and profilin1 and cofilin1 expression in hyperoxic lung injury and BPD. Respir Res. 2018 Nov 21; 19: 229.

                


                  Stapleton PA, Wingard CJ, Nurkiewicz TR, Holloway AC, Zelikoff JT, Knudsen TB, Rogers LK. Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD. Reprod Toxicol. 2018 Aug; 79: 16-20.

                


                  Ali M, Rogers LK, Heyob KM, Buhimschi CS, Buhimschi IA. Changes in Vasodilator-Stimulated Phosphoprotein Phosphorylation, Profilin-1, and Cofilin-1 in Accreta and Protection by DHA. Reprod Sci. 2018 Aug 9;  1933719118792095.

                


                  Li Q, Li R, Wall SB, Dunigan K, Ren C, Jilling T, Rogers LK, Tipple TE. Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL/6 models of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2018 May 1; 314: L736-L742.

                


                  Velten M, Heyob KM, Wold LE, Rogers LK. Perinatal inflammation induces sex-related differences in cardiovascular morbidities in mice. Am J Physiol Heart Circ Physiol. 2018 Mar 1; 314: H573-H579.

                


                  Rogers LK, Cismowski MJ. Oxidative Stress in the Lung - The Essential Paradox. Curr Opin Toxicol. 2018 Feb; 7: 37-43.

View More Publications

Professional Experience

2012 - Present Department of Pediatrics, Ohio State University, Associate Professor (with tenure)2005 - Present Columbus Children’s Research Institute, Principal Investigator2005 - 2012 Department of Pediatrics, Ohio State University, Assistant Professor2004 - 2005 Columbus Children’s Research Institute, Senior Research Scientist2000 - 2004 Columbus Children’s Research Institute, Sr. Research Associate1991 - 2000 Department of Pediatrics, Baylor College of Medicine, Research Assistant

Contact Information

Center for Perinatal Research

Call us at: (614)355-6715

                    Abigail Wexner Research Institute, Center for Perinatal Research575 Children's Crossroads, Research Building III, 6th FloorColumbus,  43215 (map)

Contact Information

Call us at: (614)355-6715

Center for Perinatal ResearchAbigail Wexner Research Institute, Center for Perinatal Research575 Children’s Crossroads, Research Building III, 6th FloorColumbus, 43215 (map)

Learn more about Lynette Kay Rogers

Biography

        Lynette K. Rogers, Ph.D. is a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. She is an Associate Professor at The Ohio State University College of Medicine. Dr. Rogers NIH-funded research focuses on lung injury and growth deficits in preterm infants.The ultimate goal of the Rogers lab is to better understand the consequences of premature birth and strive to develop efficacious treatments that would decrease morbidities in prematurely born infants. Many preterm births are a result of maternal inflammation and once born, the infant often requires oxygen therapy for survival. The combination of inflammatory stimuli results in a much more severe pathophysiology with more critical and long lasting morbidities. Our studies have identified several epigenetic markers that are affected by one or both of these adverse conditions and may be linked to further disease development. These include microRNAs, upregulation of methylation enzymes, and methylation of key genes. These markers have been identified in infants diagnosed with Bronchopulmonary dysplasia (BPD) and in our mouse model of combined inflammatory exposures. We are working to better understand the mechanisms driving these alterations, how they affect the morbidities observed, and to identify pathways that can be targeted for interventions.

Academic and Clinical Areas

Center for Perinatal Research

Interim Director

Neonatology

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Center for Perinatal Research

Awards, Honors & Organizations

Member, Perinatal Research Society, 2013 - Present Member, Sigma Xi, 2012 - Present Member, American Physiological Society, 2011 - Present Member, American Society for Nutrition, 2011 - Present Member, American Heart Association, 2011 - Present Member, American Thoracic Society, 2006 - Present Member, Society of Toxicology, 2003 - Present

Research

Lab(s)

Center for Perinatal Research

The ultimate goal of Rogers’ lab is to identify the causes of premature birth, help design treatments that would prevent prematurity, and strive to help develop efficacious treatments that would decrease morbidities in prematurely born infants. The research efforts in the lab are two fold. First, they are working to identify biomarkers early in the life of a premature infant that would predict outcomes and development of diseases and better understand the mechanisms involved in these disease processes. They use a broad scope of analytical techniques to identify alterations in proteins and lipids in both animal models of premature birth as well as human studies. Secondly, our animal models focus on inflammation resolution. Inflammation is a large component of diseases associated with prematurity, specifically those that involve the lung. Impaired inflammatory resolution may, in part, be responsible for the progression and chronic state of lung diseases in the premature infant. They are working to develop interventions that would improve inflammatory resolution in a newborn mouse model.

View My Publications

Publications

                  Fernandes J, Dunigan-Russell K, Zhong H, Lin V, Silverberg M, Moore SB, Tran V, Jones DP, Vitiello PF, Rogers LK, Tipple TE. Transcriptomic-Metabolomic Profiling in Mouse Lung Tissues Reveals Sex- and Strain-Based Differences. Metabolites. 2022 Sep 30; 12: 

                


                  Boone KM, Klebanoff MA, Rogers LK, Rausch J, Coury DL, Keim SA. Effects of Omega-3-6-9 fatty acid supplementation on behavior and sleep in preterm toddlers with autism symptomatology: Secondary analysis of a randomized clinical trial. Early Hum Dev. 2022 May 19; 169: 105588.

                


                  Adams JM, Valentine CJ, Karns RA, Rogers LK, Murase M, Fowler GN, Nommsen-Rivers LA. DHA supplementation attenuates inflammation-associated gene expression in the mammary gland of lactating mothers who deliver preterm. J Nutr. 2022 Feb 24;  

                


                  Keim SA, Jude A, Smith K, Khan AQ, Coury DL, Rausch J, Udaipuria S, Norris M, Bartram LR, Narayanan AR, Rogers LK. Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder. J Autism Dev Disord. 2022 Jan 11;  

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Rogers LK, Slaughter JL. Editorial: Developmental origins of health and disease: Impact of preterm birth. Front Pediatr. 2022; 10: 1120208.

                


                  Parad RB, Breeze JL, Terrin N, Rogers LK, Salafia CM, Greenough A, Davis JM. Differences in clinical and laboratory biomarkers for short and long-term respiratory outcomes in preterm neonates. Pediatr Pulmonol. 2021 Dec; 56: 3847-3856.

                


                  Valentine CJ, Khan AQ, Brown AR, Sands SA, Defranco EA, Gajewski BJ, Carlson SE, Reber KM, Rogers LK. Higher-Dose DHA Supplementation Modulates Immune Responses in Pregnancy and Is Associated with Decreased Preterm Birth. Nutrients. 2021 Nov 26; 13: 

                


                  Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 

                


                  Boone KM, Pattison K, Pelak G, Sheppard KW, Rausch J, Yeates KO, Nelin MA, Klebanoff MA, Turner AN, Rogers LK, Keim SA. Docosahexaenoic and arachidonic acid supplementation at 1 year has mixed effects on development and behaviour at age 2 for preterm children. Acta Paediatr. 2021 Jul; 110: 2082-2083.

                


                  Carlson SE, Gajewski BJ, Valentine CJ, Kerling EH, Weiner CP, Cackovic M, Buhimschi CS, Rogers LK, Sands SA, Brown AR, Mudaranthakam DP, Crawford SA, DeFranco EA. Higher dose docosahexaenoic acid supplementation during pregnancy and early preterm birth: A randomised, double-blind, adaptive-design superiority trial. EClinicalMedicine. 2021 Jun; 36: 100905.

                


                  Wall SB, Li R, Butler B, Burg AR, Tse HM, Larson-Casey JL, Carter AB, Wright CJ, Rogers LK, Tipple TE. Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages. Antioxidants (Basel). 2021 Apr 21; 10: 

                


                  Pavlek LR, Vudatala S, Bartlett CW, Buhimschi IA, Buhimschi CS, Rogers LK. MiR-29b is associated with perinatal inflammation in extremely preterm infants. Pediatr Res. 2021 Mar; 89: 889-893.

                


                  Robbins ME, Cho HY, Hansen JM, Luchsinger JR, Locy ML, Velten M, Kleeberger SR, Rogers LK, Tipple TE. Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice. Redox Biol. 2021 Jan; 38: 101797.

                


                  Sugar SS, Heyob KM, Cheng X, Lee RJ, Rogers LK. Perinatal inflammation alters histone 3 and histone 4 methylation patterns: Effects of MiR-29b supplementation. Redox Biol. 2021 Jan; 38: 101783.

                


                  Buhimschi CS, Bahtiyar MO, Zhao G, Abdelghany O, Schneider L, Razeq SA, Dulay AT, Lipkind HS, Mieth S, Rogers L, Bhandari V, Buhimschi IA. Antenatal N-acetylcysteine to improve outcomes of premature infants with intra-amniotic infection and inflammation (Triple I): randomized clinical trial. Pediatr Res. 2021 Jan; 89: 175-184.

                


                  Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  

                


                  Valentine CJ, Dingess KA, Kleiman J, Morrow AL, Rogers LK. A Randomized Trial of Maternal Docosahexaenoic Acid Supplementation to Reduce Inflammation in Extremely Preterm Infants. J Pediatr Gastroenterol Nutr. 2019 Apr 29;  

                


                  Keim SA, Rogers LK, Klebanoff MA. Supplementing Essential Polyunsaturated Fatty Acids-A Matter of Respecting Fetal Development-Reply. JAMA Pediatr. 2019 Mar 25;  

                


                  Kopp BT, Thompson R, Kim J, Konstan R, Diaz A, Smith B, Shrestha C, Rogers LK, Hayes D Jr, Tumin D, Woodley FW, Ramilo O, Sanders DB, Groner JA, Mejias A. Secondhand smoke alters arachidonic acid metabolism and inflammation in infants and children with cystic fibrosis. Thorax. 2019 Mar; 74: 237-246.

                


                  Wall SB, Wood R, Dunigan K, Li Q, Li R, Rogers LK, Tipple TE. Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia. Oxid Med Cell Longev. 2019; 2019: 7945983.

                


                  Ali M, Heyob K, Tipple TE, Pryhuber GS, Rogers LK. Alterations in VASP phosphorylation and profilin1 and cofilin1 expression in hyperoxic lung injury and BPD. Respir Res. 2018 Nov 21; 19: 229.

                


                  Stapleton PA, Wingard CJ, Nurkiewicz TR, Holloway AC, Zelikoff JT, Knudsen TB, Rogers LK. Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD. Reprod Toxicol. 2018 Aug; 79: 16-20.

                


                  Ali M, Rogers LK, Heyob KM, Buhimschi CS, Buhimschi IA. Changes in Vasodilator-Stimulated Phosphoprotein Phosphorylation, Profilin-1, and Cofilin-1 in Accreta and Protection by DHA. Reprod Sci. 2018 Aug 9;  1933719118792095.

                


                  Li Q, Li R, Wall SB, Dunigan K, Ren C, Jilling T, Rogers LK, Tipple TE. Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL/6 models of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2018 May 1; 314: L736-L742.

                


                  Velten M, Heyob KM, Wold LE, Rogers LK. Perinatal inflammation induces sex-related differences in cardiovascular morbidities in mice. Am J Physiol Heart Circ Physiol. 2018 Mar 1; 314: H573-H579.

                


                  Rogers LK, Cismowski MJ. Oxidative Stress in the Lung - The Essential Paradox. Curr Opin Toxicol. 2018 Feb; 7: 37-43.

View More Publications

Professional Experience

2012 - Present Department of Pediatrics, Ohio State University, Associate Professor (with tenure)2005 - Present Columbus Children’s Research Institute, Principal Investigator2005 - 2012 Department of Pediatrics, Ohio State University, Assistant Professor2004 - 2005 Columbus Children’s Research Institute, Senior Research Scientist2000 - 2004 Columbus Children’s Research Institute, Sr. Research Associate1991 - 2000 Department of Pediatrics, Baylor College of Medicine, Research Assistant

Contact Information

Center for Perinatal Research

Call us at: (614)355-6715

                    Abigail Wexner Research Institute, Center for Perinatal Research575 Children's Crossroads, Research Building III, 6th FloorColumbus,  43215 (map)

Contact Information

Call us at: (614)355-6715

Center for Perinatal ResearchAbigail Wexner Research Institute, Center for Perinatal Research575 Children’s Crossroads, Research Building III, 6th FloorColumbus, 43215 (map)

Learn more about Lynette Kay Rogers

Contact Information

  • Call us at:
  • (614)355-6715
  • Center for Perinatal ResearchAbigail Wexner Research Institute, Center for Perinatal Research575 Children’s Crossroads, Research Building III, 6th FloorColumbus, 43215 (map)

Learn more about Lynette Kay Rogers

Biography

        Lynette K. Rogers, Ph.D. is a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. She is an Associate Professor at The Ohio State University College of Medicine. Dr. Rogers NIH-funded research focuses on lung injury and growth deficits in preterm infants.The ultimate goal of the Rogers lab is to better understand the consequences of premature birth and strive to develop efficacious treatments that would decrease morbidities in prematurely born infants. Many preterm births are a result of maternal inflammation and once born, the infant often requires oxygen therapy for survival. The combination of inflammatory stimuli results in a much more severe pathophysiology with more critical and long lasting morbidities. Our studies have identified several epigenetic markers that are affected by one or both of these adverse conditions and may be linked to further disease development. These include microRNAs, upregulation of methylation enzymes, and methylation of key genes. These markers have been identified in infants diagnosed with Bronchopulmonary dysplasia (BPD) and in our mouse model of combined inflammatory exposures. We are working to better understand the mechanisms driving these alterations, how they affect the morbidities observed, and to identify pathways that can be targeted for interventions.

Biography

        Lynette K. Rogers, Ph.D. is a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. She is an Associate Professor at The Ohio State University College of Medicine. Dr. Rogers NIH-funded research focuses on lung injury and growth deficits in preterm infants.The ultimate goal of the Rogers lab is to better understand the consequences of premature birth and strive to develop efficacious treatments that would decrease morbidities in prematurely born infants. Many preterm births are a result of maternal inflammation and once born, the infant often requires oxygen therapy for survival. The combination of inflammatory stimuli results in a much more severe pathophysiology with more critical and long lasting morbidities. Our studies have identified several epigenetic markers that are affected by one or both of these adverse conditions and may be linked to further disease development. These include microRNAs, upregulation of methylation enzymes, and methylation of key genes. These markers have been identified in infants diagnosed with Bronchopulmonary dysplasia (BPD) and in our mouse model of combined inflammatory exposures. We are working to better understand the mechanisms driving these alterations, how they affect the morbidities observed, and to identify pathways that can be targeted for interventions.

Biography

        Lynette K. Rogers, Ph.D. is a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. She is an Associate Professor at The Ohio State University College of Medicine. Dr. Rogers NIH-funded research focuses on lung injury and growth deficits in preterm infants.The ultimate goal of the Rogers lab is to better understand the consequences of premature birth and strive to develop efficacious treatments that would decrease morbidities in prematurely born infants. Many preterm births are a result of maternal inflammation and once born, the infant often requires oxygen therapy for survival. The combination of inflammatory stimuli results in a much more severe pathophysiology with more critical and long lasting morbidities. Our studies have identified several epigenetic markers that are affected by one or both of these adverse conditions and may be linked to further disease development. These include microRNAs, upregulation of methylation enzymes, and methylation of key genes. These markers have been identified in infants diagnosed with Bronchopulmonary dysplasia (BPD) and in our mouse model of combined inflammatory exposures. We are working to better understand the mechanisms driving these alterations, how they affect the morbidities observed, and to identify pathways that can be targeted for interventions.



      






        Lynette K. Rogers, Ph.D. is a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. She is an Associate Professor at The Ohio State University College of Medicine. Dr. Rogers NIH-funded research focuses on lung injury and growth deficits in preterm infants.The ultimate goal of the Rogers lab is to better understand the consequences of premature birth and strive to develop efficacious treatments that would decrease morbidities in prematurely born infants. Many preterm births are a result of maternal inflammation and once born, the infant often requires oxygen therapy for survival. The combination of inflammatory stimuli results in a much more severe pathophysiology with more critical and long lasting morbidities. Our studies have identified several epigenetic markers that are affected by one or both of these adverse conditions and may be linked to further disease development. These include microRNAs, upregulation of methylation enzymes, and methylation of key genes. These markers have been identified in infants diagnosed with Bronchopulmonary dysplasia (BPD) and in our mouse model of combined inflammatory exposures. We are working to better understand the mechanisms driving these alterations, how they affect the morbidities observed, and to identify pathways that can be targeted for interventions.

Academic and Clinical Areas

Center for Perinatal Research

Interim Director

Neonatology

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Center for Perinatal Research

Academic and Clinical Areas

Center for Perinatal Research

Interim Director

Neonatology

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Center for Perinatal Research

Academic and Clinical Areas

Center for Perinatal Research

Interim Director

Neonatology

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Center for Perinatal Research

Center for Perinatal Research

Interim Director

Neonatology

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Center for Perinatal Research

  • Center for Perinatal Research
  • Interim Director
  • Neonatology
  • Principal Investigator
  • Neonatology Fellowship
  • Faculty
  • Primary Department
  • Center for Perinatal Research

Awards, Honors & Organizations

Member, Perinatal Research Society, 2013 - Present Member, Sigma Xi, 2012 - Present Member, American Physiological Society, 2011 - Present Member, American Society for Nutrition, 2011 - Present Member, American Heart Association, 2011 - Present Member, American Thoracic Society, 2006 - Present Member, Society of Toxicology, 2003 - Present

Awards, Honors & Organizations

Member, Perinatal Research Society, 2013 - Present Member, Sigma Xi, 2012 - Present Member, American Physiological Society, 2011 - Present Member, American Society for Nutrition, 2011 - Present Member, American Heart Association, 2011 - Present Member, American Thoracic Society, 2006 - Present Member, Society of Toxicology, 2003 - Present

Awards, Honors & Organizations

Member, Perinatal Research Society, 2013 - Present Member, Sigma Xi, 2012 - Present Member, American Physiological Society, 2011 - Present Member, American Society for Nutrition, 2011 - Present Member, American Heart Association, 2011 - Present Member, American Thoracic Society, 2006 - Present Member, Society of Toxicology, 2003 - Present

Member, Perinatal Research Society, 2013 - Present Member, Sigma Xi, 2012 - Present Member, American Physiological Society, 2011 - Present Member, American Society for Nutrition, 2011 - Present Member, American Heart Association, 2011 - Present Member, American Thoracic Society, 2006 - Present Member, Society of Toxicology, 2003 - Present

  • Member, Perinatal Research Society, 2013 - Present
  • Member, Sigma Xi, 2012 - Present
  • Member, American Physiological Society, 2011 - Present
  • Member, American Society for Nutrition, 2011 - Present
  • Member, American Heart Association, 2011 - Present
  • Member, American Thoracic Society, 2006 - Present
  • Member, Society of Toxicology, 2003 - Present

Research

Lab(s)

Center for Perinatal Research

The ultimate goal of Rogers’ lab is to identify the causes of premature birth, help design treatments that would prevent prematurity, and strive to help develop efficacious treatments that would decrease morbidities in prematurely born infants. The research efforts in the lab are two fold. First, they are working to identify biomarkers early in the life of a premature infant that would predict outcomes and development of diseases and better understand the mechanisms involved in these disease processes. They use a broad scope of analytical techniques to identify alterations in proteins and lipids in both animal models of premature birth as well as human studies. Secondly, our animal models focus on inflammation resolution. Inflammation is a large component of diseases associated with prematurity, specifically those that involve the lung. Impaired inflammatory resolution may, in part, be responsible for the progression and chronic state of lung diseases in the premature infant. They are working to develop interventions that would improve inflammatory resolution in a newborn mouse model.

View My Publications

Publications

                  Fernandes J, Dunigan-Russell K, Zhong H, Lin V, Silverberg M, Moore SB, Tran V, Jones DP, Vitiello PF, Rogers LK, Tipple TE. Transcriptomic-Metabolomic Profiling in Mouse Lung Tissues Reveals Sex- and Strain-Based Differences. Metabolites. 2022 Sep 30; 12: 

                


                  Boone KM, Klebanoff MA, Rogers LK, Rausch J, Coury DL, Keim SA. Effects of Omega-3-6-9 fatty acid supplementation on behavior and sleep in preterm toddlers with autism symptomatology: Secondary analysis of a randomized clinical trial. Early Hum Dev. 2022 May 19; 169: 105588.

                


                  Adams JM, Valentine CJ, Karns RA, Rogers LK, Murase M, Fowler GN, Nommsen-Rivers LA. DHA supplementation attenuates inflammation-associated gene expression in the mammary gland of lactating mothers who deliver preterm. J Nutr. 2022 Feb 24;  

                


                  Keim SA, Jude A, Smith K, Khan AQ, Coury DL, Rausch J, Udaipuria S, Norris M, Bartram LR, Narayanan AR, Rogers LK. Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder. J Autism Dev Disord. 2022 Jan 11;  

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Rogers LK, Slaughter JL. Editorial: Developmental origins of health and disease: Impact of preterm birth. Front Pediatr. 2022; 10: 1120208.

                


                  Parad RB, Breeze JL, Terrin N, Rogers LK, Salafia CM, Greenough A, Davis JM. Differences in clinical and laboratory biomarkers for short and long-term respiratory outcomes in preterm neonates. Pediatr Pulmonol. 2021 Dec; 56: 3847-3856.

                


                  Valentine CJ, Khan AQ, Brown AR, Sands SA, Defranco EA, Gajewski BJ, Carlson SE, Reber KM, Rogers LK. Higher-Dose DHA Supplementation Modulates Immune Responses in Pregnancy and Is Associated with Decreased Preterm Birth. Nutrients. 2021 Nov 26; 13: 

                


                  Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 

                


                  Boone KM, Pattison K, Pelak G, Sheppard KW, Rausch J, Yeates KO, Nelin MA, Klebanoff MA, Turner AN, Rogers LK, Keim SA. Docosahexaenoic and arachidonic acid supplementation at 1 year has mixed effects on development and behaviour at age 2 for preterm children. Acta Paediatr. 2021 Jul; 110: 2082-2083.

                


                  Carlson SE, Gajewski BJ, Valentine CJ, Kerling EH, Weiner CP, Cackovic M, Buhimschi CS, Rogers LK, Sands SA, Brown AR, Mudaranthakam DP, Crawford SA, DeFranco EA. Higher dose docosahexaenoic acid supplementation during pregnancy and early preterm birth: A randomised, double-blind, adaptive-design superiority trial. EClinicalMedicine. 2021 Jun; 36: 100905.

                


                  Wall SB, Li R, Butler B, Burg AR, Tse HM, Larson-Casey JL, Carter AB, Wright CJ, Rogers LK, Tipple TE. Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages. Antioxidants (Basel). 2021 Apr 21; 10: 

                


                  Pavlek LR, Vudatala S, Bartlett CW, Buhimschi IA, Buhimschi CS, Rogers LK. MiR-29b is associated with perinatal inflammation in extremely preterm infants. Pediatr Res. 2021 Mar; 89: 889-893.

                


                  Robbins ME, Cho HY, Hansen JM, Luchsinger JR, Locy ML, Velten M, Kleeberger SR, Rogers LK, Tipple TE. Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice. Redox Biol. 2021 Jan; 38: 101797.

                


                  Sugar SS, Heyob KM, Cheng X, Lee RJ, Rogers LK. Perinatal inflammation alters histone 3 and histone 4 methylation patterns: Effects of MiR-29b supplementation. Redox Biol. 2021 Jan; 38: 101783.

                


                  Buhimschi CS, Bahtiyar MO, Zhao G, Abdelghany O, Schneider L, Razeq SA, Dulay AT, Lipkind HS, Mieth S, Rogers L, Bhandari V, Buhimschi IA. Antenatal N-acetylcysteine to improve outcomes of premature infants with intra-amniotic infection and inflammation (Triple I): randomized clinical trial. Pediatr Res. 2021 Jan; 89: 175-184.

                


                  Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  

                


                  Valentine CJ, Dingess KA, Kleiman J, Morrow AL, Rogers LK. A Randomized Trial of Maternal Docosahexaenoic Acid Supplementation to Reduce Inflammation in Extremely Preterm Infants. J Pediatr Gastroenterol Nutr. 2019 Apr 29;  

                


                  Keim SA, Rogers LK, Klebanoff MA. Supplementing Essential Polyunsaturated Fatty Acids-A Matter of Respecting Fetal Development-Reply. JAMA Pediatr. 2019 Mar 25;  

                


                  Kopp BT, Thompson R, Kim J, Konstan R, Diaz A, Smith B, Shrestha C, Rogers LK, Hayes D Jr, Tumin D, Woodley FW, Ramilo O, Sanders DB, Groner JA, Mejias A. Secondhand smoke alters arachidonic acid metabolism and inflammation in infants and children with cystic fibrosis. Thorax. 2019 Mar; 74: 237-246.

                


                  Wall SB, Wood R, Dunigan K, Li Q, Li R, Rogers LK, Tipple TE. Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia. Oxid Med Cell Longev. 2019; 2019: 7945983.

                


                  Ali M, Heyob K, Tipple TE, Pryhuber GS, Rogers LK. Alterations in VASP phosphorylation and profilin1 and cofilin1 expression in hyperoxic lung injury and BPD. Respir Res. 2018 Nov 21; 19: 229.

                


                  Stapleton PA, Wingard CJ, Nurkiewicz TR, Holloway AC, Zelikoff JT, Knudsen TB, Rogers LK. Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD. Reprod Toxicol. 2018 Aug; 79: 16-20.

                


                  Ali M, Rogers LK, Heyob KM, Buhimschi CS, Buhimschi IA. Changes in Vasodilator-Stimulated Phosphoprotein Phosphorylation, Profilin-1, and Cofilin-1 in Accreta and Protection by DHA. Reprod Sci. 2018 Aug 9;  1933719118792095.

                


                  Li Q, Li R, Wall SB, Dunigan K, Ren C, Jilling T, Rogers LK, Tipple TE. Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL/6 models of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2018 May 1; 314: L736-L742.

                


                  Velten M, Heyob KM, Wold LE, Rogers LK. Perinatal inflammation induces sex-related differences in cardiovascular morbidities in mice. Am J Physiol Heart Circ Physiol. 2018 Mar 1; 314: H573-H579.

                


                  Rogers LK, Cismowski MJ. Oxidative Stress in the Lung - The Essential Paradox. Curr Opin Toxicol. 2018 Feb; 7: 37-43.

View More Publications

Research

Lab(s)

Center for Perinatal Research

The ultimate goal of Rogers’ lab is to identify the causes of premature birth, help design treatments that would prevent prematurity, and strive to help develop efficacious treatments that would decrease morbidities in prematurely born infants. The research efforts in the lab are two fold. First, they are working to identify biomarkers early in the life of a premature infant that would predict outcomes and development of diseases and better understand the mechanisms involved in these disease processes. They use a broad scope of analytical techniques to identify alterations in proteins and lipids in both animal models of premature birth as well as human studies. Secondly, our animal models focus on inflammation resolution. Inflammation is a large component of diseases associated with prematurity, specifically those that involve the lung. Impaired inflammatory resolution may, in part, be responsible for the progression and chronic state of lung diseases in the premature infant. They are working to develop interventions that would improve inflammatory resolution in a newborn mouse model.

View My Publications

Publications

                  Fernandes J, Dunigan-Russell K, Zhong H, Lin V, Silverberg M, Moore SB, Tran V, Jones DP, Vitiello PF, Rogers LK, Tipple TE. Transcriptomic-Metabolomic Profiling in Mouse Lung Tissues Reveals Sex- and Strain-Based Differences. Metabolites. 2022 Sep 30; 12: 

                


                  Boone KM, Klebanoff MA, Rogers LK, Rausch J, Coury DL, Keim SA. Effects of Omega-3-6-9 fatty acid supplementation on behavior and sleep in preterm toddlers with autism symptomatology: Secondary analysis of a randomized clinical trial. Early Hum Dev. 2022 May 19; 169: 105588.

                


                  Adams JM, Valentine CJ, Karns RA, Rogers LK, Murase M, Fowler GN, Nommsen-Rivers LA. DHA supplementation attenuates inflammation-associated gene expression in the mammary gland of lactating mothers who deliver preterm. J Nutr. 2022 Feb 24;  

                


                  Keim SA, Jude A, Smith K, Khan AQ, Coury DL, Rausch J, Udaipuria S, Norris M, Bartram LR, Narayanan AR, Rogers LK. Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder. J Autism Dev Disord. 2022 Jan 11;  

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Rogers LK, Slaughter JL. Editorial: Developmental origins of health and disease: Impact of preterm birth. Front Pediatr. 2022; 10: 1120208.

                


                  Parad RB, Breeze JL, Terrin N, Rogers LK, Salafia CM, Greenough A, Davis JM. Differences in clinical and laboratory biomarkers for short and long-term respiratory outcomes in preterm neonates. Pediatr Pulmonol. 2021 Dec; 56: 3847-3856.

                


                  Valentine CJ, Khan AQ, Brown AR, Sands SA, Defranco EA, Gajewski BJ, Carlson SE, Reber KM, Rogers LK. Higher-Dose DHA Supplementation Modulates Immune Responses in Pregnancy and Is Associated with Decreased Preterm Birth. Nutrients. 2021 Nov 26; 13: 

                


                  Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 

                


                  Boone KM, Pattison K, Pelak G, Sheppard KW, Rausch J, Yeates KO, Nelin MA, Klebanoff MA, Turner AN, Rogers LK, Keim SA. Docosahexaenoic and arachidonic acid supplementation at 1 year has mixed effects on development and behaviour at age 2 for preterm children. Acta Paediatr. 2021 Jul; 110: 2082-2083.

                


                  Carlson SE, Gajewski BJ, Valentine CJ, Kerling EH, Weiner CP, Cackovic M, Buhimschi CS, Rogers LK, Sands SA, Brown AR, Mudaranthakam DP, Crawford SA, DeFranco EA. Higher dose docosahexaenoic acid supplementation during pregnancy and early preterm birth: A randomised, double-blind, adaptive-design superiority trial. EClinicalMedicine. 2021 Jun; 36: 100905.

                


                  Wall SB, Li R, Butler B, Burg AR, Tse HM, Larson-Casey JL, Carter AB, Wright CJ, Rogers LK, Tipple TE. Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages. Antioxidants (Basel). 2021 Apr 21; 10: 

                


                  Pavlek LR, Vudatala S, Bartlett CW, Buhimschi IA, Buhimschi CS, Rogers LK. MiR-29b is associated with perinatal inflammation in extremely preterm infants. Pediatr Res. 2021 Mar; 89: 889-893.

                


                  Robbins ME, Cho HY, Hansen JM, Luchsinger JR, Locy ML, Velten M, Kleeberger SR, Rogers LK, Tipple TE. Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice. Redox Biol. 2021 Jan; 38: 101797.

                


                  Sugar SS, Heyob KM, Cheng X, Lee RJ, Rogers LK. Perinatal inflammation alters histone 3 and histone 4 methylation patterns: Effects of MiR-29b supplementation. Redox Biol. 2021 Jan; 38: 101783.

                


                  Buhimschi CS, Bahtiyar MO, Zhao G, Abdelghany O, Schneider L, Razeq SA, Dulay AT, Lipkind HS, Mieth S, Rogers L, Bhandari V, Buhimschi IA. Antenatal N-acetylcysteine to improve outcomes of premature infants with intra-amniotic infection and inflammation (Triple I): randomized clinical trial. Pediatr Res. 2021 Jan; 89: 175-184.

                


                  Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  

                


                  Valentine CJ, Dingess KA, Kleiman J, Morrow AL, Rogers LK. A Randomized Trial of Maternal Docosahexaenoic Acid Supplementation to Reduce Inflammation in Extremely Preterm Infants. J Pediatr Gastroenterol Nutr. 2019 Apr 29;  

                


                  Keim SA, Rogers LK, Klebanoff MA. Supplementing Essential Polyunsaturated Fatty Acids-A Matter of Respecting Fetal Development-Reply. JAMA Pediatr. 2019 Mar 25;  

                


                  Kopp BT, Thompson R, Kim J, Konstan R, Diaz A, Smith B, Shrestha C, Rogers LK, Hayes D Jr, Tumin D, Woodley FW, Ramilo O, Sanders DB, Groner JA, Mejias A. Secondhand smoke alters arachidonic acid metabolism and inflammation in infants and children with cystic fibrosis. Thorax. 2019 Mar; 74: 237-246.

                


                  Wall SB, Wood R, Dunigan K, Li Q, Li R, Rogers LK, Tipple TE. Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia. Oxid Med Cell Longev. 2019; 2019: 7945983.

                


                  Ali M, Heyob K, Tipple TE, Pryhuber GS, Rogers LK. Alterations in VASP phosphorylation and profilin1 and cofilin1 expression in hyperoxic lung injury and BPD. Respir Res. 2018 Nov 21; 19: 229.

                


                  Stapleton PA, Wingard CJ, Nurkiewicz TR, Holloway AC, Zelikoff JT, Knudsen TB, Rogers LK. Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD. Reprod Toxicol. 2018 Aug; 79: 16-20.

                


                  Ali M, Rogers LK, Heyob KM, Buhimschi CS, Buhimschi IA. Changes in Vasodilator-Stimulated Phosphoprotein Phosphorylation, Profilin-1, and Cofilin-1 in Accreta and Protection by DHA. Reprod Sci. 2018 Aug 9;  1933719118792095.

                


                  Li Q, Li R, Wall SB, Dunigan K, Ren C, Jilling T, Rogers LK, Tipple TE. Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL/6 models of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2018 May 1; 314: L736-L742.

                


                  Velten M, Heyob KM, Wold LE, Rogers LK. Perinatal inflammation induces sex-related differences in cardiovascular morbidities in mice. Am J Physiol Heart Circ Physiol. 2018 Mar 1; 314: H573-H579.

                


                  Rogers LK, Cismowski MJ. Oxidative Stress in the Lung - The Essential Paradox. Curr Opin Toxicol. 2018 Feb; 7: 37-43.

View More Publications

Research

Lab(s)

Center for Perinatal Research

The ultimate goal of Rogers’ lab is to identify the causes of premature birth, help design treatments that would prevent prematurity, and strive to help develop efficacious treatments that would decrease morbidities in prematurely born infants. The research efforts in the lab are two fold. First, they are working to identify biomarkers early in the life of a premature infant that would predict outcomes and development of diseases and better understand the mechanisms involved in these disease processes. They use a broad scope of analytical techniques to identify alterations in proteins and lipids in both animal models of premature birth as well as human studies. Secondly, our animal models focus on inflammation resolution. Inflammation is a large component of diseases associated with prematurity, specifically those that involve the lung. Impaired inflammatory resolution may, in part, be responsible for the progression and chronic state of lung diseases in the premature infant. They are working to develop interventions that would improve inflammatory resolution in a newborn mouse model.

View My Publications

Publications

                  Fernandes J, Dunigan-Russell K, Zhong H, Lin V, Silverberg M, Moore SB, Tran V, Jones DP, Vitiello PF, Rogers LK, Tipple TE. Transcriptomic-Metabolomic Profiling in Mouse Lung Tissues Reveals Sex- and Strain-Based Differences. Metabolites. 2022 Sep 30; 12: 

                


                  Boone KM, Klebanoff MA, Rogers LK, Rausch J, Coury DL, Keim SA. Effects of Omega-3-6-9 fatty acid supplementation on behavior and sleep in preterm toddlers with autism symptomatology: Secondary analysis of a randomized clinical trial. Early Hum Dev. 2022 May 19; 169: 105588.

                


                  Adams JM, Valentine CJ, Karns RA, Rogers LK, Murase M, Fowler GN, Nommsen-Rivers LA. DHA supplementation attenuates inflammation-associated gene expression in the mammary gland of lactating mothers who deliver preterm. J Nutr. 2022 Feb 24;  

                


                  Keim SA, Jude A, Smith K, Khan AQ, Coury DL, Rausch J, Udaipuria S, Norris M, Bartram LR, Narayanan AR, Rogers LK. Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder. J Autism Dev Disord. 2022 Jan 11;  

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Rogers LK, Slaughter JL. Editorial: Developmental origins of health and disease: Impact of preterm birth. Front Pediatr. 2022; 10: 1120208.

                


                  Parad RB, Breeze JL, Terrin N, Rogers LK, Salafia CM, Greenough A, Davis JM. Differences in clinical and laboratory biomarkers for short and long-term respiratory outcomes in preterm neonates. Pediatr Pulmonol. 2021 Dec; 56: 3847-3856.

                


                  Valentine CJ, Khan AQ, Brown AR, Sands SA, Defranco EA, Gajewski BJ, Carlson SE, Reber KM, Rogers LK. Higher-Dose DHA Supplementation Modulates Immune Responses in Pregnancy and Is Associated with Decreased Preterm Birth. Nutrients. 2021 Nov 26; 13: 

                


                  Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 

                


                  Boone KM, Pattison K, Pelak G, Sheppard KW, Rausch J, Yeates KO, Nelin MA, Klebanoff MA, Turner AN, Rogers LK, Keim SA. Docosahexaenoic and arachidonic acid supplementation at 1 year has mixed effects on development and behaviour at age 2 for preterm children. Acta Paediatr. 2021 Jul; 110: 2082-2083.

                


                  Carlson SE, Gajewski BJ, Valentine CJ, Kerling EH, Weiner CP, Cackovic M, Buhimschi CS, Rogers LK, Sands SA, Brown AR, Mudaranthakam DP, Crawford SA, DeFranco EA. Higher dose docosahexaenoic acid supplementation during pregnancy and early preterm birth: A randomised, double-blind, adaptive-design superiority trial. EClinicalMedicine. 2021 Jun; 36: 100905.

                


                  Wall SB, Li R, Butler B, Burg AR, Tse HM, Larson-Casey JL, Carter AB, Wright CJ, Rogers LK, Tipple TE. Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages. Antioxidants (Basel). 2021 Apr 21; 10: 

                


                  Pavlek LR, Vudatala S, Bartlett CW, Buhimschi IA, Buhimschi CS, Rogers LK. MiR-29b is associated with perinatal inflammation in extremely preterm infants. Pediatr Res. 2021 Mar; 89: 889-893.

                


                  Robbins ME, Cho HY, Hansen JM, Luchsinger JR, Locy ML, Velten M, Kleeberger SR, Rogers LK, Tipple TE. Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice. Redox Biol. 2021 Jan; 38: 101797.

                


                  Sugar SS, Heyob KM, Cheng X, Lee RJ, Rogers LK. Perinatal inflammation alters histone 3 and histone 4 methylation patterns: Effects of MiR-29b supplementation. Redox Biol. 2021 Jan; 38: 101783.

                


                  Buhimschi CS, Bahtiyar MO, Zhao G, Abdelghany O, Schneider L, Razeq SA, Dulay AT, Lipkind HS, Mieth S, Rogers L, Bhandari V, Buhimschi IA. Antenatal N-acetylcysteine to improve outcomes of premature infants with intra-amniotic infection and inflammation (Triple I): randomized clinical trial. Pediatr Res. 2021 Jan; 89: 175-184.

                


                  Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  

                


                  Valentine CJ, Dingess KA, Kleiman J, Morrow AL, Rogers LK. A Randomized Trial of Maternal Docosahexaenoic Acid Supplementation to Reduce Inflammation in Extremely Preterm Infants. J Pediatr Gastroenterol Nutr. 2019 Apr 29;  

                


                  Keim SA, Rogers LK, Klebanoff MA. Supplementing Essential Polyunsaturated Fatty Acids-A Matter of Respecting Fetal Development-Reply. JAMA Pediatr. 2019 Mar 25;  

                


                  Kopp BT, Thompson R, Kim J, Konstan R, Diaz A, Smith B, Shrestha C, Rogers LK, Hayes D Jr, Tumin D, Woodley FW, Ramilo O, Sanders DB, Groner JA, Mejias A. Secondhand smoke alters arachidonic acid metabolism and inflammation in infants and children with cystic fibrosis. Thorax. 2019 Mar; 74: 237-246.

                


                  Wall SB, Wood R, Dunigan K, Li Q, Li R, Rogers LK, Tipple TE. Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia. Oxid Med Cell Longev. 2019; 2019: 7945983.

                


                  Ali M, Heyob K, Tipple TE, Pryhuber GS, Rogers LK. Alterations in VASP phosphorylation and profilin1 and cofilin1 expression in hyperoxic lung injury and BPD. Respir Res. 2018 Nov 21; 19: 229.

                


                  Stapleton PA, Wingard CJ, Nurkiewicz TR, Holloway AC, Zelikoff JT, Knudsen TB, Rogers LK. Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD. Reprod Toxicol. 2018 Aug; 79: 16-20.

                


                  Ali M, Rogers LK, Heyob KM, Buhimschi CS, Buhimschi IA. Changes in Vasodilator-Stimulated Phosphoprotein Phosphorylation, Profilin-1, and Cofilin-1 in Accreta and Protection by DHA. Reprod Sci. 2018 Aug 9;  1933719118792095.

                


                  Li Q, Li R, Wall SB, Dunigan K, Ren C, Jilling T, Rogers LK, Tipple TE. Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL/6 models of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2018 May 1; 314: L736-L742.

                


                  Velten M, Heyob KM, Wold LE, Rogers LK. Perinatal inflammation induces sex-related differences in cardiovascular morbidities in mice. Am J Physiol Heart Circ Physiol. 2018 Mar 1; 314: H573-H579.

                


                  Rogers LK, Cismowski MJ. Oxidative Stress in the Lung - The Essential Paradox. Curr Opin Toxicol. 2018 Feb; 7: 37-43.

View More Publications

Lab(s)

Center for Perinatal Research

The ultimate goal of Rogers’ lab is to identify the causes of premature birth, help design treatments that would prevent prematurity, and strive to help develop efficacious treatments that would decrease morbidities in prematurely born infants. The research efforts in the lab are two fold. First, they are working to identify biomarkers early in the life of a premature infant that would predict outcomes and development of diseases and better understand the mechanisms involved in these disease processes. They use a broad scope of analytical techniques to identify alterations in proteins and lipids in both animal models of premature birth as well as human studies. Secondly, our animal models focus on inflammation resolution. Inflammation is a large component of diseases associated with prematurity, specifically those that involve the lung. Impaired inflammatory resolution may, in part, be responsible for the progression and chronic state of lung diseases in the premature infant. They are working to develop interventions that would improve inflammatory resolution in a newborn mouse model.

View My Publications

Publications

                  Fernandes J, Dunigan-Russell K, Zhong H, Lin V, Silverberg M, Moore SB, Tran V, Jones DP, Vitiello PF, Rogers LK, Tipple TE. Transcriptomic-Metabolomic Profiling in Mouse Lung Tissues Reveals Sex- and Strain-Based Differences. Metabolites. 2022 Sep 30; 12: 

                


                  Boone KM, Klebanoff MA, Rogers LK, Rausch J, Coury DL, Keim SA. Effects of Omega-3-6-9 fatty acid supplementation on behavior and sleep in preterm toddlers with autism symptomatology: Secondary analysis of a randomized clinical trial. Early Hum Dev. 2022 May 19; 169: 105588.

                


                  Adams JM, Valentine CJ, Karns RA, Rogers LK, Murase M, Fowler GN, Nommsen-Rivers LA. DHA supplementation attenuates inflammation-associated gene expression in the mammary gland of lactating mothers who deliver preterm. J Nutr. 2022 Feb 24;  

                


                  Keim SA, Jude A, Smith K, Khan AQ, Coury DL, Rausch J, Udaipuria S, Norris M, Bartram LR, Narayanan AR, Rogers LK. Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder. J Autism Dev Disord. 2022 Jan 11;  

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Rogers LK, Slaughter JL. Editorial: Developmental origins of health and disease: Impact of preterm birth. Front Pediatr. 2022; 10: 1120208.

                


                  Parad RB, Breeze JL, Terrin N, Rogers LK, Salafia CM, Greenough A, Davis JM. Differences in clinical and laboratory biomarkers for short and long-term respiratory outcomes in preterm neonates. Pediatr Pulmonol. 2021 Dec; 56: 3847-3856.

                


                  Valentine CJ, Khan AQ, Brown AR, Sands SA, Defranco EA, Gajewski BJ, Carlson SE, Reber KM, Rogers LK. Higher-Dose DHA Supplementation Modulates Immune Responses in Pregnancy and Is Associated with Decreased Preterm Birth. Nutrients. 2021 Nov 26; 13: 

                


                  Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 

                


                  Boone KM, Pattison K, Pelak G, Sheppard KW, Rausch J, Yeates KO, Nelin MA, Klebanoff MA, Turner AN, Rogers LK, Keim SA. Docosahexaenoic and arachidonic acid supplementation at 1 year has mixed effects on development and behaviour at age 2 for preterm children. Acta Paediatr. 2021 Jul; 110: 2082-2083.

                


                  Carlson SE, Gajewski BJ, Valentine CJ, Kerling EH, Weiner CP, Cackovic M, Buhimschi CS, Rogers LK, Sands SA, Brown AR, Mudaranthakam DP, Crawford SA, DeFranco EA. Higher dose docosahexaenoic acid supplementation during pregnancy and early preterm birth: A randomised, double-blind, adaptive-design superiority trial. EClinicalMedicine. 2021 Jun; 36: 100905.

                


                  Wall SB, Li R, Butler B, Burg AR, Tse HM, Larson-Casey JL, Carter AB, Wright CJ, Rogers LK, Tipple TE. Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages. Antioxidants (Basel). 2021 Apr 21; 10: 

                


                  Pavlek LR, Vudatala S, Bartlett CW, Buhimschi IA, Buhimschi CS, Rogers LK. MiR-29b is associated with perinatal inflammation in extremely preterm infants. Pediatr Res. 2021 Mar; 89: 889-893.

                


                  Robbins ME, Cho HY, Hansen JM, Luchsinger JR, Locy ML, Velten M, Kleeberger SR, Rogers LK, Tipple TE. Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice. Redox Biol. 2021 Jan; 38: 101797.

                


                  Sugar SS, Heyob KM, Cheng X, Lee RJ, Rogers LK. Perinatal inflammation alters histone 3 and histone 4 methylation patterns: Effects of MiR-29b supplementation. Redox Biol. 2021 Jan; 38: 101783.

                


                  Buhimschi CS, Bahtiyar MO, Zhao G, Abdelghany O, Schneider L, Razeq SA, Dulay AT, Lipkind HS, Mieth S, Rogers L, Bhandari V, Buhimschi IA. Antenatal N-acetylcysteine to improve outcomes of premature infants with intra-amniotic infection and inflammation (Triple I): randomized clinical trial. Pediatr Res. 2021 Jan; 89: 175-184.

                


                  Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  

                


                  Valentine CJ, Dingess KA, Kleiman J, Morrow AL, Rogers LK. A Randomized Trial of Maternal Docosahexaenoic Acid Supplementation to Reduce Inflammation in Extremely Preterm Infants. J Pediatr Gastroenterol Nutr. 2019 Apr 29;  

                


                  Keim SA, Rogers LK, Klebanoff MA. Supplementing Essential Polyunsaturated Fatty Acids-A Matter of Respecting Fetal Development-Reply. JAMA Pediatr. 2019 Mar 25;  

                


                  Kopp BT, Thompson R, Kim J, Konstan R, Diaz A, Smith B, Shrestha C, Rogers LK, Hayes D Jr, Tumin D, Woodley FW, Ramilo O, Sanders DB, Groner JA, Mejias A. Secondhand smoke alters arachidonic acid metabolism and inflammation in infants and children with cystic fibrosis. Thorax. 2019 Mar; 74: 237-246.

                


                  Wall SB, Wood R, Dunigan K, Li Q, Li R, Rogers LK, Tipple TE. Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia. Oxid Med Cell Longev. 2019; 2019: 7945983.

                


                  Ali M, Heyob K, Tipple TE, Pryhuber GS, Rogers LK. Alterations in VASP phosphorylation and profilin1 and cofilin1 expression in hyperoxic lung injury and BPD. Respir Res. 2018 Nov 21; 19: 229.

                


                  Stapleton PA, Wingard CJ, Nurkiewicz TR, Holloway AC, Zelikoff JT, Knudsen TB, Rogers LK. Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD. Reprod Toxicol. 2018 Aug; 79: 16-20.

                


                  Ali M, Rogers LK, Heyob KM, Buhimschi CS, Buhimschi IA. Changes in Vasodilator-Stimulated Phosphoprotein Phosphorylation, Profilin-1, and Cofilin-1 in Accreta and Protection by DHA. Reprod Sci. 2018 Aug 9;  1933719118792095.

                


                  Li Q, Li R, Wall SB, Dunigan K, Ren C, Jilling T, Rogers LK, Tipple TE. Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL/6 models of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2018 May 1; 314: L736-L742.

                


                  Velten M, Heyob KM, Wold LE, Rogers LK. Perinatal inflammation induces sex-related differences in cardiovascular morbidities in mice. Am J Physiol Heart Circ Physiol. 2018 Mar 1; 314: H573-H579.

                


                  Rogers LK, Cismowski MJ. Oxidative Stress in the Lung - The Essential Paradox. Curr Opin Toxicol. 2018 Feb; 7: 37-43.

View More Publications

Lab(s)

Center for Perinatal Research

The ultimate goal of Rogers’ lab is to identify the causes of premature birth, help design treatments that would prevent prematurity, and strive to help develop efficacious treatments that would decrease morbidities in prematurely born infants. The research efforts in the lab are two fold. First, they are working to identify biomarkers early in the life of a premature infant that would predict outcomes and development of diseases and better understand the mechanisms involved in these disease processes. They use a broad scope of analytical techniques to identify alterations in proteins and lipids in both animal models of premature birth as well as human studies. Secondly, our animal models focus on inflammation resolution. Inflammation is a large component of diseases associated with prematurity, specifically those that involve the lung. Impaired inflammatory resolution may, in part, be responsible for the progression and chronic state of lung diseases in the premature infant. They are working to develop interventions that would improve inflammatory resolution in a newborn mouse model.

Lab(s)

Center for Perinatal Research

  • Center for Perinatal Research

  • View My Publications

                    Fernandes J, Dunigan-Russell K, Zhong H, Lin V, Silverberg M, Moore SB, Tran V, Jones DP, Vitiello PF, Rogers LK, Tipple TE. Transcriptomic-Metabolomic Profiling in Mouse Lung Tissues Reveals Sex- and Strain-Based Differences. Metabolites. 2022 Sep 30; 12: 



                Boone KM, Klebanoff MA, Rogers LK, Rausch J, Coury DL, Keim SA. Effects of Omega-3-6-9 fatty acid supplementation on behavior and sleep in preterm toddlers with autism symptomatology: Secondary analysis of a randomized clinical trial. Early Hum Dev. 2022 May 19; 169: 105588.



                Adams JM, Valentine CJ, Karns RA, Rogers LK, Murase M, Fowler GN, Nommsen-Rivers LA. DHA supplementation attenuates inflammation-associated gene expression in the mammary gland of lactating mothers who deliver preterm. J Nutr. 2022 Feb 24;  



                Keim SA, Jude A, Smith K, Khan AQ, Coury DL, Rausch J, Udaipuria S, Norris M, Bartram LR, Narayanan AR, Rogers LK. Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder. J Autism Dev Disord. 2022 Jan 11;  



                Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  



                Rogers LK, Slaughter JL. Editorial: Developmental origins of health and disease: Impact of preterm birth. Front Pediatr. 2022; 10: 1120208.



                Parad RB, Breeze JL, Terrin N, Rogers LK, Salafia CM, Greenough A, Davis JM. Differences in clinical and laboratory biomarkers for short and long-term respiratory outcomes in preterm neonates. Pediatr Pulmonol. 2021 Dec; 56: 3847-3856.



                Valentine CJ, Khan AQ, Brown AR, Sands SA, Defranco EA, Gajewski BJ, Carlson SE, Reber KM, Rogers LK. Higher-Dose DHA Supplementation Modulates Immune Responses in Pregnancy and Is Associated with Decreased Preterm Birth. Nutrients. 2021 Nov 26; 13: 



                Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10: 



                Boone KM, Pattison K, Pelak G, Sheppard KW, Rausch J, Yeates KO, Nelin MA, Klebanoff MA, Turner AN, Rogers LK, Keim SA. Docosahexaenoic and arachidonic acid supplementation at 1 year has mixed effects on development and behaviour at age 2 for preterm children. Acta Paediatr. 2021 Jul; 110: 2082-2083.



                Carlson SE, Gajewski BJ, Valentine CJ, Kerling EH, Weiner CP, Cackovic M, Buhimschi CS, Rogers LK, Sands SA, Brown AR, Mudaranthakam DP, Crawford SA, DeFranco EA. Higher dose docosahexaenoic acid supplementation during pregnancy and early preterm birth: A randomised, double-blind, adaptive-design superiority trial. EClinicalMedicine. 2021 Jun; 36: 100905.



                Wall SB, Li R, Butler B, Burg AR, Tse HM, Larson-Casey JL, Carter AB, Wright CJ, Rogers LK, Tipple TE. Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages. Antioxidants (Basel). 2021 Apr 21; 10: 



                Pavlek LR, Vudatala S, Bartlett CW, Buhimschi IA, Buhimschi CS, Rogers LK. MiR-29b is associated with perinatal inflammation in extremely preterm infants. Pediatr Res. 2021 Mar; 89: 889-893.



                Robbins ME, Cho HY, Hansen JM, Luchsinger JR, Locy ML, Velten M, Kleeberger SR, Rogers LK, Tipple TE. Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice. Redox Biol. 2021 Jan; 38: 101797.



                Sugar SS, Heyob KM, Cheng X, Lee RJ, Rogers LK. Perinatal inflammation alters histone 3 and histone 4 methylation patterns: Effects of MiR-29b supplementation. Redox Biol. 2021 Jan; 38: 101783.



                Buhimschi CS, Bahtiyar MO, Zhao G, Abdelghany O, Schneider L, Razeq SA, Dulay AT, Lipkind HS, Mieth S, Rogers L, Bhandari V, Buhimschi IA. Antenatal N-acetylcysteine to improve outcomes of premature infants with intra-amniotic infection and inflammation (Triple I): randomized clinical trial. Pediatr Res. 2021 Jan; 89: 175-184.



                Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;  



                Valentine CJ, Dingess KA, Kleiman J, Morrow AL, Rogers LK. A Randomized Trial of Maternal Docosahexaenoic Acid Supplementation to Reduce Inflammation in Extremely Preterm Infants. J Pediatr Gastroenterol Nutr. 2019 Apr 29;  



                Keim SA, Rogers LK, Klebanoff MA. Supplementing Essential Polyunsaturated Fatty Acids-A Matter of Respecting Fetal Development-Reply. JAMA Pediatr. 2019 Mar 25;  



                Kopp BT, Thompson R, Kim J, Konstan R, Diaz A, Smith B, Shrestha C, Rogers LK, Hayes D Jr, Tumin D, Woodley FW, Ramilo O, Sanders DB, Groner JA, Mejias A. Secondhand smoke alters arachidonic acid metabolism and inflammation in infants and children with cystic fibrosis. Thorax. 2019 Mar; 74: 237-246.



                Wall SB, Wood R, Dunigan K, Li Q, Li R, Rogers LK, Tipple TE. Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia. Oxid Med Cell Longev. 2019; 2019: 7945983.



                Ali M, Heyob K, Tipple TE, Pryhuber GS, Rogers LK. Alterations in VASP phosphorylation and profilin1 and cofilin1 expression in hyperoxic lung injury and BPD. Respir Res. 2018 Nov 21; 19: 229.



                Stapleton PA, Wingard CJ, Nurkiewicz TR, Holloway AC, Zelikoff JT, Knudsen TB, Rogers LK. Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD. Reprod Toxicol. 2018 Aug; 79: 16-20.



                Ali M, Rogers LK, Heyob KM, Buhimschi CS, Buhimschi IA. Changes in Vasodilator-Stimulated Phosphoprotein Phosphorylation, Profilin-1, and Cofilin-1 in Accreta and Protection by DHA. Reprod Sci. 2018 Aug 9;  1933719118792095.



                Li Q, Li R, Wall SB, Dunigan K, Ren C, Jilling T, Rogers LK, Tipple TE. Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL/6 models of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2018 May 1; 314: L736-L742.



                Velten M, Heyob KM, Wold LE, Rogers LK. Perinatal inflammation induces sex-related differences in cardiovascular morbidities in mice. Am J Physiol Heart Circ Physiol. 2018 Mar 1; 314: H573-H579.



                Rogers LK, Cismowski MJ. Oxidative Stress in the Lung - The Essential Paradox. Curr Opin Toxicol. 2018 Feb; 7: 37-43.

View More Publications

  • Fernandes J, Dunigan-Russell K, Zhong H, Lin V, Silverberg M, Moore SB, Tran V, Jones DP, Vitiello PF, Rogers LK, Tipple TE. Transcriptomic-Metabolomic Profiling in Mouse Lung Tissues Reveals Sex- and Strain-Based Differences. Metabolites. 2022 Sep 30; 12:
  • Boone KM, Klebanoff MA, Rogers LK, Rausch J, Coury DL, Keim SA. Effects of Omega-3-6-9 fatty acid supplementation on behavior and sleep in preterm toddlers with autism symptomatology: Secondary analysis of a randomized clinical trial. Early Hum Dev. 2022 May 19; 169: 105588.
  • Adams JM, Valentine CJ, Karns RA, Rogers LK, Murase M, Fowler GN, Nommsen-Rivers LA. DHA supplementation attenuates inflammation-associated gene expression in the mammary gland of lactating mothers who deliver preterm. J Nutr. 2022 Feb 24;
  • Keim SA, Jude A, Smith K, Khan AQ, Coury DL, Rausch J, Udaipuria S, Norris M, Bartram LR, Narayanan AR, Rogers LK. Randomized Controlled Trial of Omega-3 and -6 Fatty Acid Supplementation to Reduce Inflammatory Markers in Children with Autism Spectrum Disorder. J Autism Dev Disord. 2022 Jan 11;
  • Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;
  • Rogers LK, Slaughter JL. Editorial: Developmental origins of health and disease: Impact of preterm birth. Front Pediatr. 2022; 10: 1120208.
  • Parad RB, Breeze JL, Terrin N, Rogers LK, Salafia CM, Greenough A, Davis JM. Differences in clinical and laboratory biomarkers for short and long-term respiratory outcomes in preterm neonates. Pediatr Pulmonol. 2021 Dec; 56: 3847-3856.
  • Valentine CJ, Khan AQ, Brown AR, Sands SA, Defranco EA, Gajewski BJ, Carlson SE, Reber KM, Rogers LK. Higher-Dose DHA Supplementation Modulates Immune Responses in Pregnancy and Is Associated with Decreased Preterm Birth. Nutrients. 2021 Nov 26; 13:
  • Lewis BW, Ford ML, Rogers LK, Britt RD Jr. Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD. Antioxidants (Basel). 2021 Aug 24; 10:
  • Boone KM, Pattison K, Pelak G, Sheppard KW, Rausch J, Yeates KO, Nelin MA, Klebanoff MA, Turner AN, Rogers LK, Keim SA. Docosahexaenoic and arachidonic acid supplementation at 1 year has mixed effects on development and behaviour at age 2 for preterm children. Acta Paediatr. 2021 Jul; 110: 2082-2083.
  • Carlson SE, Gajewski BJ, Valentine CJ, Kerling EH, Weiner CP, Cackovic M, Buhimschi CS, Rogers LK, Sands SA, Brown AR, Mudaranthakam DP, Crawford SA, DeFranco EA. Higher dose docosahexaenoic acid supplementation during pregnancy and early preterm birth: A randomised, double-blind, adaptive-design superiority trial. EClinicalMedicine. 2021 Jun; 36: 100905.
  • Wall SB, Li R, Butler B, Burg AR, Tse HM, Larson-Casey JL, Carter AB, Wright CJ, Rogers LK, Tipple TE. Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages. Antioxidants (Basel). 2021 Apr 21; 10:
  • Pavlek LR, Vudatala S, Bartlett CW, Buhimschi IA, Buhimschi CS, Rogers LK. MiR-29b is associated with perinatal inflammation in extremely preterm infants. Pediatr Res. 2021 Mar; 89: 889-893.
  • Robbins ME, Cho HY, Hansen JM, Luchsinger JR, Locy ML, Velten M, Kleeberger SR, Rogers LK, Tipple TE. Glutathione reductase deficiency alters lung development and hyperoxic responses in neonatal mice. Redox Biol. 2021 Jan; 38: 101797.
  • Sugar SS, Heyob KM, Cheng X, Lee RJ, Rogers LK. Perinatal inflammation alters histone 3 and histone 4 methylation patterns: Effects of MiR-29b supplementation. Redox Biol. 2021 Jan; 38: 101783.
  • Buhimschi CS, Bahtiyar MO, Zhao G, Abdelghany O, Schneider L, Razeq SA, Dulay AT, Lipkind HS, Mieth S, Rogers L, Bhandari V, Buhimschi IA. Antenatal N-acetylcysteine to improve outcomes of premature infants with intra-amniotic infection and inflammation (Triple I): randomized clinical trial. Pediatr Res. 2021 Jan; 89: 175-184.
  • Heyob KM, Mieth S, Sugar SS, Graf AE, Lallier SW, Britt RD Jr, Rogers LK. Maternal High Fat Diet Alters Lung Development and Function in the Offspring. Am J Physiol Lung Cell Mol Physiol. 2019 May 1;
  • Valentine CJ, Dingess KA, Kleiman J, Morrow AL, Rogers LK. A Randomized Trial of Maternal Docosahexaenoic Acid Supplementation to Reduce Inflammation in Extremely Preterm Infants. J Pediatr Gastroenterol Nutr. 2019 Apr 29;
  • Keim SA, Rogers LK, Klebanoff MA. Supplementing Essential Polyunsaturated Fatty Acids-A Matter of Respecting Fetal Development-Reply. JAMA Pediatr. 2019 Mar 25;
  • Kopp BT, Thompson R, Kim J, Konstan R, Diaz A, Smith B, Shrestha C, Rogers LK, Hayes D Jr, Tumin D, Woodley FW, Ramilo O, Sanders DB, Groner JA, Mejias A. Secondhand smoke alters arachidonic acid metabolism and inflammation in infants and children with cystic fibrosis. Thorax. 2019 Mar; 74: 237-246.
  • Wall SB, Wood R, Dunigan K, Li Q, Li R, Rogers LK, Tipple TE. Thioredoxin Reductase-1 Inhibition Augments Endogenous Glutathione-Dependent Antioxidant Responses in Experimental Bronchopulmonary Dysplasia. Oxid Med Cell Longev. 2019; 2019: 7945983.
  • Ali M, Heyob K, Tipple TE, Pryhuber GS, Rogers LK. Alterations in VASP phosphorylation and profilin1 and cofilin1 expression in hyperoxic lung injury and BPD. Respir Res. 2018 Nov 21; 19: 229.
  • Stapleton PA, Wingard CJ, Nurkiewicz TR, Holloway AC, Zelikoff JT, Knudsen TB, Rogers LK. Cardiopulmonary consequences of gestational toxicant exposure: Symposium overview at the 56th annual SOT meeting, Baltimore, MD. Reprod Toxicol. 2018 Aug; 79: 16-20.
  • Ali M, Rogers LK, Heyob KM, Buhimschi CS, Buhimschi IA. Changes in Vasodilator-Stimulated Phosphoprotein Phosphorylation, Profilin-1, and Cofilin-1 in Accreta and Protection by DHA. Reprod Sci. 2018 Aug 9; 1933719118792095.
  • Li Q, Li R, Wall SB, Dunigan K, Ren C, Jilling T, Rogers LK, Tipple TE. Aurothioglucose does not improve alveolarization or elicit sustained Nrf2 activation in C57BL/6 models of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2018 May 1; 314: L736-L742.
  • Velten M, Heyob KM, Wold LE, Rogers LK. Perinatal inflammation induces sex-related differences in cardiovascular morbidities in mice. Am J Physiol Heart Circ Physiol. 2018 Mar 1; 314: H573-H579.
  • Rogers LK, Cismowski MJ. Oxidative Stress in the Lung - The Essential Paradox. Curr Opin Toxicol. 2018 Feb; 7: 37-43.

Professional Experience

2012 - Present Department of Pediatrics, Ohio State University, Associate Professor (with tenure)2005 - Present Columbus Children’s Research Institute, Principal Investigator2005 - 2012 Department of Pediatrics, Ohio State University, Assistant Professor2004 - 2005 Columbus Children’s Research Institute, Senior Research Scientist2000 - 2004 Columbus Children’s Research Institute, Sr. Research Associate1991 - 2000 Department of Pediatrics, Baylor College of Medicine, Research Assistant

Professional Experience

2012 - Present Department of Pediatrics, Ohio State University, Associate Professor (with tenure)2005 - Present Columbus Children’s Research Institute, Principal Investigator2005 - 2012 Department of Pediatrics, Ohio State University, Assistant Professor2004 - 2005 Columbus Children’s Research Institute, Senior Research Scientist2000 - 2004 Columbus Children’s Research Institute, Sr. Research Associate1991 - 2000 Department of Pediatrics, Baylor College of Medicine, Research Assistant

Professional Experience

2012 - Present Department of Pediatrics, Ohio State University, Associate Professor (with tenure)2005 - Present Columbus Children’s Research Institute, Principal Investigator2005 - 2012 Department of Pediatrics, Ohio State University, Assistant Professor2004 - 2005 Columbus Children’s Research Institute, Senior Research Scientist2000 - 2004 Columbus Children’s Research Institute, Sr. Research Associate1991 - 2000 Department of Pediatrics, Baylor College of Medicine, Research Assistant

2012 - Present Department of Pediatrics, Ohio State University, Associate Professor (with tenure)2005 - Present Columbus Children’s Research Institute, Principal Investigator2005 - 2012 Department of Pediatrics, Ohio State University, Assistant Professor2004 - 2005 Columbus Children’s Research Institute, Senior Research Scientist2000 - 2004 Columbus Children’s Research Institute, Sr. Research Associate1991 - 2000 Department of Pediatrics, Baylor College of Medicine, Research Assistant

2012 - Present Department of Pediatrics, Ohio State University, Associate Professor (with tenure)

Contact Information

Center for Perinatal Research

Call us at: (614)355-6715

                    Abigail Wexner Research Institute, Center for Perinatal Research575 Children's Crossroads, Research Building III, 6th FloorColumbus,  43215 (map)

Contact Information

Center for Perinatal Research

Call us at: (614)355-6715

                    Abigail Wexner Research Institute, Center for Perinatal Research575 Children's Crossroads, Research Building III, 6th FloorColumbus,  43215 (map)

Contact Information

Center for Perinatal Research

Call us at: (614)355-6715

                    Abigail Wexner Research Institute, Center for Perinatal Research575 Children's Crossroads, Research Building III, 6th FloorColumbus,  43215 (map)

Center for Perinatal Research

Call us at: (614)355-6715

                    Abigail Wexner Research Institute, Center for Perinatal Research575 Children's Crossroads, Research Building III, 6th FloorColumbus,  43215 (map)

Call us at: (614)355-6715

                    Abigail Wexner Research Institute, Center for Perinatal Research575 Children's Crossroads, Research Building III, 6th FloorColumbus,  43215 (map)

Call us at: (614)355-6715

                    Abigail Wexner Research Institute, Center for Perinatal Research575 Children's Crossroads, Research Building III, 6th FloorColumbus,  43215 (map)
  • Call us at:
  • (614)355-6715
  • Abigail Wexner Research Institute, Center for Perinatal Research575 Children’s Crossroads, Research Building III, 6th FloorColumbus, 43215 (map)