Leif D Nelin

Contact Information

Call us at: (614) 722-4559

Fax us at: (614) 722-4541

PediatricsNeonatology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Leif D. Nelin

Biography

Dr. Nelin is the Division Chief of Neonatology at Nationwide Children’s Hospital, Dean Jeffers Endowed Chair in Neonatology and a Professor of Pediatrics at The Ohio State University College of Medicine. Clinically, Dr. Nelin is particularly interested in respiratory diseases, specifically in how pulmonary blood flow affects newborn respiratory diseases. Thus, persistent pulmonary hypertension of the newborn(PPHN) is one of his primary clinical interests. This has lead to his research interest in nitric oxide (NO), a potent vasodilator whose production is decreased in patients with PPHN. Utilizing cell culture techniques, isolated perfused lungs and animal preparations, Dr. Nelin studies the mechanisms that determine biological availability of the amino acid L-arginine on the ability of the lungs to produce NO and thereby regulate blood flow. The ultimate goal of this research is to understand the pathophysiology of PPHN and to develop new and specific therapies for the treatment of lung diseases that are characterized by alterations in NO production. A second area of research interest is the study of the developmental toxicology of inhaled NO.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Swedish

Academic and Clinical Areas

Neonatology

Division Chief

Center for Perinatal Research

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Neonatology

Awards, Honors & Organizations

Listed, Best Doctors in America

Research

Lab(s)

Center for Perinatal Research

The research focus in Leif Nelin’s laboratory is on the elucidation of the functional and mechanistic aspects of cellular uptake of L-arginine by the cationic amino acid transporters (CAT) and the role of CAT activities and expression in regulation of nitric oxide (NO) production in the lung. Furthermore, they are studying the regulation of nitric oxide synthase and arginase induction in models of pulmonary hypertension and lung injury to develop strategies to influence arginine metabolism inside of the cell. Experiments are carried out in cell culture systems and animal models using pharmacological and genetic manipulations with experimental end-points ranging from biochemical assays, protein and mRNA assays, to functional and physiological measurements. The long-term goals of these studies are to develop therapies that increase NO production by facilitating CAT-mediated L-arg uptake in pulmonary hypertensive diseases, and that decrease NO production by inhibiting CAT-mediated L-arg uptake in inflammatory lung diseases. Publications

                  Nelin LD, Shepherd EG. Bones and lungs: insights from mice with fragile bones. J Physiol. 2022 Dec 14;  

                


                  Fortney CA, Baughcum AE, Garcia D, Winning AM, Humphrey L, Cistone N, Moscato EL, Keim MC, Nelin LD, Gerhardt CA. Characteristics of Critically Ill Infants at the End of Life in the Neonatal Intensive Care Unit. J Palliat Med. 2022 Dec 8;  

                


                  Cristea AI, Tracy MC, Bauer SE, Guaman MC, Welty SE, Baker CD, Bhombal S, Collaco JM, Courtney SE, DiGeronimo RJ, Eldredge LC, Gibbs K, Hayden LP, Keszler M, Lai K, McGrath-Morrow SA, Moore PE, Rose R, Sindelar R, Truog WE, Nelin LD, Abman S, BPD Collaborative. Approaches to Interdisciplinary Care for Infants with Severe Bronchopulmonary Dysplasia: A Survey of the Bronchopulmonary Dysplasia Collaborative. Am J Perinatol. 2022 Dec 7;  

                


                  Levin JC, Annesi CA, Williams DN, Abman SH, McGrath-Morrow SA, Nelin LD, Sheils CA, Hayden LP, Bronchopulmonary Dysplasia Collaborative Expert Panel on Discharge Practices.. Discharge Practices for Infants with Bronchopulmonary Dysplasia: A Survey of National Experts. J Pediatr. 2022 Sep 17;  

                


                  Lewis TR, Kielt MJ, Walker VP, Levin JC, Guaman MC, Panitch HB, Nelin LD, Abman SH, Bronchopulmonary Dysplasia Collaborative.. Association of Racial Disparities With In-Hospital Outcomes in Severe Bronchopulmonary Dysplasia. JAMA Pediatr. 2022 Aug 1;  

                


                  McGrath-Morrow SA, Agarwal A, Alexiou S, Austin ED, Fierro JL, Hayden LP, Lai K, Levin JC, Manimtim WM, Moore PE, Rhein LM, Rice JL, Sheils CA, Tracy MC, Bansal M, Baker CD, Cristea AI, Popova AP, Siddaiah R, Villafranco N, Nelin LD, Collaco JM. Daycare Attendance is linked to Increased Risk of Respiratory Morbidities in Preterm Children with Bronchopulmonary Dysplasia. J Pediatr. 2022 Jul 5;  

                


                  Nelin LD, Kielt MJ, Jebbia M, Jadcherla S, Shepherd EG. Bronchodilator responsiveness and dysanapsis in bronchopulmonary dysplasia. ERJ Open Res. 2022 Jul; 8: 

                


                  Miller CJ, Prusakov P, Magers J, Speaks S, Sacic H, Escobar K, Abdel-Rasoul M, Nelin LD. Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit. J Perinatol. 2022 Jun 25;  

                


                  Chen B, Jin Y, Pool CM, Liu Y, Nelin LD. Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation. Physiol Rep. 2022 Jun; 10: e15342.

                


                  Collaco JM, Tracy MC, Sheils CA, Rice JL, Rhein LM, Nelin LD, Moore PE, Manimtim WM, Levin JC, Lai K, Hayden LP, Fierro JL, Austin ED, Alexiou S, Agarwal A, Villafranco N, Siddaiah R, Popova AP, Cristea IA, Baker CD, Bansal M, McGrath-Morrow SA. Insurance coverage and respiratory morbidities in bronchopulmonary dysplasia. Pediatr Pulmonol. 2022 Apr 18;  

                


                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Logan JW, Bapat R, Ryshen G, Bagwell G, Eisner M, Kielt M, Hanawalt M, Payne K, Alt-Coan A, Tatad M, Krendl D, Jebbia M, Reber KM, Halling C, Osman AA, Bonachea EM, Nelin LD, Fathi O. Use of a quality scorecard to enhance quality and safety in community hospital newborn nurseries. J Pediatr. 2022 Mar 28;  

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Lee CD, Nelin L, Foglia EE. Neonatal Resuscitation in 22-Week Pregnancies. N Engl J Med. 2022 Jan 27; 386: 391-393.

                


                  Miller AN, Kielt MJ, El-Ferzli GT, Nelin LD, Shepherd EG. Optimizing ventilator support in severe bronchopulmonary dysplasia in the absence of conclusive evidence. Front Pediatr. 2022; 10: 1022743.

                


                  Sindelar R, Shepherd EG, Ågren J, Panitch HB, Abman SH, Nelin LD, Bronchopulmonary Dysplasia Collaborative.. Established severe BPD: is there a way out? Change of ventilatory paradigms. Pediatr Res. 2021 Dec; 90: 1139-1146.

                


                  Pavlek LR, Mueller C, Jebbia MR, Kielt MJ, Nelin LD, Shepherd EG, Reber KM, Fathi O. Perspectives on developing and sustaining a small baby program. Semin Perinatol. 2021 Nov 10;  151548.

                


                  Trittmann JK, Almazroue H, Nelin LD, Shaffer TA, Celestine CR, Green HW 3rd, Malbrue RA. PATET ratio by Doppler echocardiography: noninvasive detection of pediatric pulmonary arterial hypertension. Pediatr Res. 2021 Nov 18;  

                


                  Kielt MJ, Logan JW, Backes CH, Conroy S, Reber KM, Shepherd EG, Nelin LD. Noninvasive Respiratory Severity Indices Predict Adverse Outcomes in Bronchopulmonary Dysplasia. J Pediatr. 2021 Nov 11;  

                


                  Yallapragada S, Savani RC, Munoz-Blanco S, Lagatta JM, Truog WE, Porta NFM, Nelin LD, Zhang H, Vyas-Read S, DiGeronimo R, Natarajan G, Wymore E, Haberman B, Machry J, Potoka K, Children’s Hospital Neonatal Consortium severe bronchopulmonary dysplasia subgroup., Murthy K. Qualitative indications for tracheostomy and chronic mechanical ventilation in patients with severe bronchopulmonary dysplasia. J Perinatol. 2021 Nov; 41: 2651-2657.

                


                  Kielt MJ, Murphy A, Smathers J, Bates M, Nelin LD, Shepherd EG. In-Hospital Respiratory Viral Infections for Patients with Established BPD in the SARS-CoV-2 Era. Pediatr Pulmonol. 2021 Oct 1;  

                


                  Nelin L, Kinsella JP, Courtney SE, Pallotto EK, Tarau E, Potenziano JL. Use of inhaled nitric oxide in preterm vs term/near-term neonates with pulmonary hypertension: results of the PaTTerN registry study. J Perinatol. 2021 Oct 28;  

                


                  Vyas-Read S, Logan JW, Cuna AC, Machry J, Leeman KT, Rose RS, Mikhael M, Wymore E, Ibrahim JW, DiGeronimo RJ, Yallapragada S, Haberman BE, Padula MA, Porta NF, Murthy K, Nelin LD, Coghill CH, Zaniletti I, Savani RC, Truog W, Engle WA, Lagatta JM. A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children's Hospitals Neonatal Consortium Severe BPD Group. J Perinatol. 2021 Aug 5;  

                


                  Guaman MC, Pishevar N, Abman SH, Keszler M, Truog WE, Panitch H, Nelin LD. Invasive mechanical ventilation at 36 weeks post-menstrual age, adverse outcomes with a comparison of recent definitions of bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1936-1942.

                


                  Kielt MJ, Logan JW, Backes CH, Reber KM, Nelin LD, Shepherd EG. In-hospital outcomes of late referrals for established bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1972-1982.

                


                  Hoffsten A, Markasz L, Ericson K, Nelin LD, Sindelar R. The value of autopsy in preterm infants at a Swedish tertiary neonatal intensive care unit 2002-2018. Sci Rep. 2021 Jul 8; 11: 14156.

                


                  Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  

                


                  Collaco JM, Agarwal A, Austin ED, Hayden LP, Lai K, Levin J, Manimtim WM, Moore PE, Sheils CA, Tracy MC, Alexiou S, Baker CD, Cristea AI, Fierro JL, Rhein LM, Villafranco N, Nelin LD, McGrath-Morrow SA. Characteristics of infants or children presenting to outpatient bronchopulmonary dysplasia clinics in the United States. Pediatr Pulmonol. 2021 Jun; 56: 1617-1625.

                


                  Fathi O, Nelin LD, Shepherd EG, Reber KM. Development of a small baby unit to improve outcomes for the extremely premature infant. J Perinatol. 2021 Mar 12;  

                


                  Stewart WCL, Gnona KM, White P, Kelly B, Klebanoff M, Buhimschi IA, Nelin LD. Prediction of short-term neonatal complications in preterm infants using exome-wide genetic variation and gestational age: a pilot study. Pediatr Res. 2020 Oct; 88: 653-660.

                


                  Pishevar N, Fathi O, Backes CH, Shepherd EG, Nelin LD. Predicting survival in infants born at <27 weeks gestation admitted to an all referral neonatal intensive care unit: a pilot study. J Perinatol. 2020 May; 40: 750-757.

                


                  Bapat R, Nelin L, Shepherd E, Ryshen G, Elgin A, Bartman T. A multidisciplinary quality improvement effort to reduce bronchopulmonary dysplasia incidence. J Perinatol. 2020 Apr; 40: 681-687.

                


                  Bauer SE, Schneider L, Lynch SK, Malleske DT, Shepherd EG, Nelin LD. Factors Associated with Neurodevelopmental Impairment in Bronchopulmonary Dysplasia. J Pediatr. 2020 Jan 8;  

                


                  Vyas-Read S, Wymore EM, Zaniletti I, Murthy K, Padula MA, Truog WE, Engle WA, Savani RC, Yallapragada S, Logan JW, Zhang H, Hysinger EB, Grover TR, Natarajan G, Nelin LD, Porta NFM, Potoka KP, DiGeronimo R, Lagatta JM, Children’s Hospitals Neonatal Consortium Severe BPD Focus Group.. Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia. J Perinatol. 2019 Sep 30;  

                


                  Trittmann JK, Almazroue H, Jin Y, Nelin LD. DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells. Physiol Rep. 2019 Jul; 7: e14150.

                


                  Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.

                


                  Nelin LD, Potenziano JL. Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response. BMC Pediatr. 2019 Jan 12; 19: 17.

                


                  Backes CH, Söderström F, Ågren J, Sindelar R, Bartlett CW, Rivera BK, Mitchell CC, Frey HA, Shepherd EG, Nelin LD, Normann E. Outcomes following a comprehensive versus a selective approach for infants born at 22 weeks of gestation. J Perinatol. 2019 Jan; 39: 39-47.

                


                  Li J, Wang X, Ackerman WE 4th, Batty AJ, Kirk SG, White WM, Wang X, Anastasakis D, Samavati L, Buhimschi I, Nelin LD, Hafner M, Liu Y. Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis. Int J Mol Sci. 2018 Dec 6; 19: 

                


                  Zhang H, Dysart K, Kendrick DE, Li L, Das A, Hintz SR, Vohr BR, Stoll BJ, Higgins RD, Nelin L, Carlton DP, Walsh MC, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Prolonged respiratory support of any type impacts outcomes of extremely low birth weight infants. Pediatr Pulmonol. 2018 Oct; 53: 1447-1455.

                


                  Lagatta JM, Hysinger EB, Zaniletti I, Wymore EM, Vyas-Read S, Yallapragada S, Nelin LD, Truog WE, Padula MA, Porta NFM, Savani RC, Potoka KP, Kawut SM, DiGeronimo R, Natarajan G, Zhang H, Grover TR, Engle WA, Murthy K, Children's Hospital Neonatal Consortium Severe BPD Focus Group.. The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year. J Pediatr. 2018 Aug 29;  

                


                  Nelin TD, Shepherd EG, Nelin LD. In Response to Letter from Altit, Basso, Grandi, and Yang. J Perinatol. 2018 Jun; 38: 768.

                


                  Trittmann JK, Velten M, Heyob KM, Almazroue H, Jin Y, Nelin LD, Rogers LK. Arginase and a-smooth muscle actin induction after hyperoxic exposure in a mouse model of bronchopulmonary dysplasia. Clin Exp Pharmacol Physiol. 2018 Jun; 45: 556-562.

                


                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

                


                  Nelin LD, Shepherd EG. Disappointing results: a call to action. J Thorac Dis. 2018 Feb; 10: 631-633.

                


                  James J, Munson D, DeMauro SB, Langer JC, Dworetz AR, Natarajan G, Bidegain M, Fortney CA, Seabrook R, Vohr BR, Tyson JE, Bell EF, Poindexter BB, Shankaran S, Higgins RD, Das A, Stoll BJ, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr. 2017 Nov; 190: 118-123.e4.

                


                  Nelin LD, Logan JW. The use of inhaled corticosteroids in chronically ventilated preterm infants. Semin Fetal Neonatal Med. 2017 Oct; 22: 296-301.

                


                  Shepherd EG, Nelin LD. Preterm Birth, Bronchopulmonary Dysplasia, and Long-Term Respiratory Disease. Am J Respir Crit Care Med. 2017 Aug 1; 196: 264-265.

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 05/23/2003

Board Certifications

Neonatal-Perinatal Medicine

Fellowship

Baylor College of Medicine

Date Completed: 06/30/1988

Residency

Uppsala University

Date Completed: 01/01/1986

Residency

Baylor College of Medicine

Date Completed: 06/30/1985

Internship

Baylor College of Medicine

Date Completed: 06/30/1983

Medical School

University of South Florida

Date Completed: 06/12/1982

Professional Experience

2010 - Present Division of Neonatology, The Ohio State University, Interim Chief2007 - Present Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Director2002 - Present Department of Pediatrics, Ohio State University, Associate Professor2006 - 2007 Center for Perinatal Research, Nationwide Children’s Research Institute, Interim Director2002 - 2006 Center for Developmental Pharmacology and Toxicology, Columbus Children’s Research Institute, Investigator1998 - 2002 Department of Pediatrics, University of New Mexico, Associate Professor1994 - 1998 Department of Pediatrics, Medical College of Wisconsin, Associate Professor1994 - 1998 Biomedical engineering Department, Marquette University, Adjunct Associate Professor1989 - 1994 Department of Pediatrics, Medical College of Wisconsin, Assistant Professor

Contact Information

Pediatrics

Call us at: (614) 722-4559

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-4559

Fax us at: (614) 722-4541

PediatricsNeonatology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Leif D. Nelin

Biography

Dr. Nelin is the Division Chief of Neonatology at Nationwide Children’s Hospital, Dean Jeffers Endowed Chair in Neonatology and a Professor of Pediatrics at The Ohio State University College of Medicine. Clinically, Dr. Nelin is particularly interested in respiratory diseases, specifically in how pulmonary blood flow affects newborn respiratory diseases. Thus, persistent pulmonary hypertension of the newborn(PPHN) is one of his primary clinical interests. This has lead to his research interest in nitric oxide (NO), a potent vasodilator whose production is decreased in patients with PPHN. Utilizing cell culture techniques, isolated perfused lungs and animal preparations, Dr. Nelin studies the mechanisms that determine biological availability of the amino acid L-arginine on the ability of the lungs to produce NO and thereby regulate blood flow. The ultimate goal of this research is to understand the pathophysiology of PPHN and to develop new and specific therapies for the treatment of lung diseases that are characterized by alterations in NO production. A second area of research interest is the study of the developmental toxicology of inhaled NO.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Swedish

Academic and Clinical Areas

Neonatology

Division Chief

Center for Perinatal Research

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Neonatology

Awards, Honors & Organizations

Listed, Best Doctors in America

Research

Lab(s)

Center for Perinatal Research

The research focus in Leif Nelin’s laboratory is on the elucidation of the functional and mechanistic aspects of cellular uptake of L-arginine by the cationic amino acid transporters (CAT) and the role of CAT activities and expression in regulation of nitric oxide (NO) production in the lung. Furthermore, they are studying the regulation of nitric oxide synthase and arginase induction in models of pulmonary hypertension and lung injury to develop strategies to influence arginine metabolism inside of the cell. Experiments are carried out in cell culture systems and animal models using pharmacological and genetic manipulations with experimental end-points ranging from biochemical assays, protein and mRNA assays, to functional and physiological measurements. The long-term goals of these studies are to develop therapies that increase NO production by facilitating CAT-mediated L-arg uptake in pulmonary hypertensive diseases, and that decrease NO production by inhibiting CAT-mediated L-arg uptake in inflammatory lung diseases. Publications

                  Nelin LD, Shepherd EG. Bones and lungs: insights from mice with fragile bones. J Physiol. 2022 Dec 14;  

                


                  Fortney CA, Baughcum AE, Garcia D, Winning AM, Humphrey L, Cistone N, Moscato EL, Keim MC, Nelin LD, Gerhardt CA. Characteristics of Critically Ill Infants at the End of Life in the Neonatal Intensive Care Unit. J Palliat Med. 2022 Dec 8;  

                


                  Cristea AI, Tracy MC, Bauer SE, Guaman MC, Welty SE, Baker CD, Bhombal S, Collaco JM, Courtney SE, DiGeronimo RJ, Eldredge LC, Gibbs K, Hayden LP, Keszler M, Lai K, McGrath-Morrow SA, Moore PE, Rose R, Sindelar R, Truog WE, Nelin LD, Abman S, BPD Collaborative. Approaches to Interdisciplinary Care for Infants with Severe Bronchopulmonary Dysplasia: A Survey of the Bronchopulmonary Dysplasia Collaborative. Am J Perinatol. 2022 Dec 7;  

                


                  Levin JC, Annesi CA, Williams DN, Abman SH, McGrath-Morrow SA, Nelin LD, Sheils CA, Hayden LP, Bronchopulmonary Dysplasia Collaborative Expert Panel on Discharge Practices.. Discharge Practices for Infants with Bronchopulmonary Dysplasia: A Survey of National Experts. J Pediatr. 2022 Sep 17;  

                


                  Lewis TR, Kielt MJ, Walker VP, Levin JC, Guaman MC, Panitch HB, Nelin LD, Abman SH, Bronchopulmonary Dysplasia Collaborative.. Association of Racial Disparities With In-Hospital Outcomes in Severe Bronchopulmonary Dysplasia. JAMA Pediatr. 2022 Aug 1;  

                


                  McGrath-Morrow SA, Agarwal A, Alexiou S, Austin ED, Fierro JL, Hayden LP, Lai K, Levin JC, Manimtim WM, Moore PE, Rhein LM, Rice JL, Sheils CA, Tracy MC, Bansal M, Baker CD, Cristea AI, Popova AP, Siddaiah R, Villafranco N, Nelin LD, Collaco JM. Daycare Attendance is linked to Increased Risk of Respiratory Morbidities in Preterm Children with Bronchopulmonary Dysplasia. J Pediatr. 2022 Jul 5;  

                


                  Nelin LD, Kielt MJ, Jebbia M, Jadcherla S, Shepherd EG. Bronchodilator responsiveness and dysanapsis in bronchopulmonary dysplasia. ERJ Open Res. 2022 Jul; 8: 

                


                  Miller CJ, Prusakov P, Magers J, Speaks S, Sacic H, Escobar K, Abdel-Rasoul M, Nelin LD. Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit. J Perinatol. 2022 Jun 25;  

                


                  Chen B, Jin Y, Pool CM, Liu Y, Nelin LD. Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation. Physiol Rep. 2022 Jun; 10: e15342.

                


                  Collaco JM, Tracy MC, Sheils CA, Rice JL, Rhein LM, Nelin LD, Moore PE, Manimtim WM, Levin JC, Lai K, Hayden LP, Fierro JL, Austin ED, Alexiou S, Agarwal A, Villafranco N, Siddaiah R, Popova AP, Cristea IA, Baker CD, Bansal M, McGrath-Morrow SA. Insurance coverage and respiratory morbidities in bronchopulmonary dysplasia. Pediatr Pulmonol. 2022 Apr 18;  

                


                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Logan JW, Bapat R, Ryshen G, Bagwell G, Eisner M, Kielt M, Hanawalt M, Payne K, Alt-Coan A, Tatad M, Krendl D, Jebbia M, Reber KM, Halling C, Osman AA, Bonachea EM, Nelin LD, Fathi O. Use of a quality scorecard to enhance quality and safety in community hospital newborn nurseries. J Pediatr. 2022 Mar 28;  

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Lee CD, Nelin L, Foglia EE. Neonatal Resuscitation in 22-Week Pregnancies. N Engl J Med. 2022 Jan 27; 386: 391-393.

                


                  Miller AN, Kielt MJ, El-Ferzli GT, Nelin LD, Shepherd EG. Optimizing ventilator support in severe bronchopulmonary dysplasia in the absence of conclusive evidence. Front Pediatr. 2022; 10: 1022743.

                


                  Sindelar R, Shepherd EG, Ågren J, Panitch HB, Abman SH, Nelin LD, Bronchopulmonary Dysplasia Collaborative.. Established severe BPD: is there a way out? Change of ventilatory paradigms. Pediatr Res. 2021 Dec; 90: 1139-1146.

                


                  Pavlek LR, Mueller C, Jebbia MR, Kielt MJ, Nelin LD, Shepherd EG, Reber KM, Fathi O. Perspectives on developing and sustaining a small baby program. Semin Perinatol. 2021 Nov 10;  151548.

                


                  Trittmann JK, Almazroue H, Nelin LD, Shaffer TA, Celestine CR, Green HW 3rd, Malbrue RA. PATET ratio by Doppler echocardiography: noninvasive detection of pediatric pulmonary arterial hypertension. Pediatr Res. 2021 Nov 18;  

                


                  Kielt MJ, Logan JW, Backes CH, Conroy S, Reber KM, Shepherd EG, Nelin LD. Noninvasive Respiratory Severity Indices Predict Adverse Outcomes in Bronchopulmonary Dysplasia. J Pediatr. 2021 Nov 11;  

                


                  Yallapragada S, Savani RC, Munoz-Blanco S, Lagatta JM, Truog WE, Porta NFM, Nelin LD, Zhang H, Vyas-Read S, DiGeronimo R, Natarajan G, Wymore E, Haberman B, Machry J, Potoka K, Children’s Hospital Neonatal Consortium severe bronchopulmonary dysplasia subgroup., Murthy K. Qualitative indications for tracheostomy and chronic mechanical ventilation in patients with severe bronchopulmonary dysplasia. J Perinatol. 2021 Nov; 41: 2651-2657.

                


                  Kielt MJ, Murphy A, Smathers J, Bates M, Nelin LD, Shepherd EG. In-Hospital Respiratory Viral Infections for Patients with Established BPD in the SARS-CoV-2 Era. Pediatr Pulmonol. 2021 Oct 1;  

                


                  Nelin L, Kinsella JP, Courtney SE, Pallotto EK, Tarau E, Potenziano JL. Use of inhaled nitric oxide in preterm vs term/near-term neonates with pulmonary hypertension: results of the PaTTerN registry study. J Perinatol. 2021 Oct 28;  

                


                  Vyas-Read S, Logan JW, Cuna AC, Machry J, Leeman KT, Rose RS, Mikhael M, Wymore E, Ibrahim JW, DiGeronimo RJ, Yallapragada S, Haberman BE, Padula MA, Porta NF, Murthy K, Nelin LD, Coghill CH, Zaniletti I, Savani RC, Truog W, Engle WA, Lagatta JM. A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children's Hospitals Neonatal Consortium Severe BPD Group. J Perinatol. 2021 Aug 5;  

                


                  Guaman MC, Pishevar N, Abman SH, Keszler M, Truog WE, Panitch H, Nelin LD. Invasive mechanical ventilation at 36 weeks post-menstrual age, adverse outcomes with a comparison of recent definitions of bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1936-1942.

                


                  Kielt MJ, Logan JW, Backes CH, Reber KM, Nelin LD, Shepherd EG. In-hospital outcomes of late referrals for established bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1972-1982.

                


                  Hoffsten A, Markasz L, Ericson K, Nelin LD, Sindelar R. The value of autopsy in preterm infants at a Swedish tertiary neonatal intensive care unit 2002-2018. Sci Rep. 2021 Jul 8; 11: 14156.

                


                  Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  

                


                  Collaco JM, Agarwal A, Austin ED, Hayden LP, Lai K, Levin J, Manimtim WM, Moore PE, Sheils CA, Tracy MC, Alexiou S, Baker CD, Cristea AI, Fierro JL, Rhein LM, Villafranco N, Nelin LD, McGrath-Morrow SA. Characteristics of infants or children presenting to outpatient bronchopulmonary dysplasia clinics in the United States. Pediatr Pulmonol. 2021 Jun; 56: 1617-1625.

                


                  Fathi O, Nelin LD, Shepherd EG, Reber KM. Development of a small baby unit to improve outcomes for the extremely premature infant. J Perinatol. 2021 Mar 12;  

                


                  Stewart WCL, Gnona KM, White P, Kelly B, Klebanoff M, Buhimschi IA, Nelin LD. Prediction of short-term neonatal complications in preterm infants using exome-wide genetic variation and gestational age: a pilot study. Pediatr Res. 2020 Oct; 88: 653-660.

                


                  Pishevar N, Fathi O, Backes CH, Shepherd EG, Nelin LD. Predicting survival in infants born at <27 weeks gestation admitted to an all referral neonatal intensive care unit: a pilot study. J Perinatol. 2020 May; 40: 750-757.

                


                  Bapat R, Nelin L, Shepherd E, Ryshen G, Elgin A, Bartman T. A multidisciplinary quality improvement effort to reduce bronchopulmonary dysplasia incidence. J Perinatol. 2020 Apr; 40: 681-687.

                


                  Bauer SE, Schneider L, Lynch SK, Malleske DT, Shepherd EG, Nelin LD. Factors Associated with Neurodevelopmental Impairment in Bronchopulmonary Dysplasia. J Pediatr. 2020 Jan 8;  

                


                  Vyas-Read S, Wymore EM, Zaniletti I, Murthy K, Padula MA, Truog WE, Engle WA, Savani RC, Yallapragada S, Logan JW, Zhang H, Hysinger EB, Grover TR, Natarajan G, Nelin LD, Porta NFM, Potoka KP, DiGeronimo R, Lagatta JM, Children’s Hospitals Neonatal Consortium Severe BPD Focus Group.. Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia. J Perinatol. 2019 Sep 30;  

                


                  Trittmann JK, Almazroue H, Jin Y, Nelin LD. DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells. Physiol Rep. 2019 Jul; 7: e14150.

                


                  Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.

                


                  Nelin LD, Potenziano JL. Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response. BMC Pediatr. 2019 Jan 12; 19: 17.

                


                  Backes CH, Söderström F, Ågren J, Sindelar R, Bartlett CW, Rivera BK, Mitchell CC, Frey HA, Shepherd EG, Nelin LD, Normann E. Outcomes following a comprehensive versus a selective approach for infants born at 22 weeks of gestation. J Perinatol. 2019 Jan; 39: 39-47.

                


                  Li J, Wang X, Ackerman WE 4th, Batty AJ, Kirk SG, White WM, Wang X, Anastasakis D, Samavati L, Buhimschi I, Nelin LD, Hafner M, Liu Y. Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis. Int J Mol Sci. 2018 Dec 6; 19: 

                


                  Zhang H, Dysart K, Kendrick DE, Li L, Das A, Hintz SR, Vohr BR, Stoll BJ, Higgins RD, Nelin L, Carlton DP, Walsh MC, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Prolonged respiratory support of any type impacts outcomes of extremely low birth weight infants. Pediatr Pulmonol. 2018 Oct; 53: 1447-1455.

                


                  Lagatta JM, Hysinger EB, Zaniletti I, Wymore EM, Vyas-Read S, Yallapragada S, Nelin LD, Truog WE, Padula MA, Porta NFM, Savani RC, Potoka KP, Kawut SM, DiGeronimo R, Natarajan G, Zhang H, Grover TR, Engle WA, Murthy K, Children's Hospital Neonatal Consortium Severe BPD Focus Group.. The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year. J Pediatr. 2018 Aug 29;  

                


                  Nelin TD, Shepherd EG, Nelin LD. In Response to Letter from Altit, Basso, Grandi, and Yang. J Perinatol. 2018 Jun; 38: 768.

                


                  Trittmann JK, Velten M, Heyob KM, Almazroue H, Jin Y, Nelin LD, Rogers LK. Arginase and a-smooth muscle actin induction after hyperoxic exposure in a mouse model of bronchopulmonary dysplasia. Clin Exp Pharmacol Physiol. 2018 Jun; 45: 556-562.

                


                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

                


                  Nelin LD, Shepherd EG. Disappointing results: a call to action. J Thorac Dis. 2018 Feb; 10: 631-633.

                


                  James J, Munson D, DeMauro SB, Langer JC, Dworetz AR, Natarajan G, Bidegain M, Fortney CA, Seabrook R, Vohr BR, Tyson JE, Bell EF, Poindexter BB, Shankaran S, Higgins RD, Das A, Stoll BJ, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr. 2017 Nov; 190: 118-123.e4.

                


                  Nelin LD, Logan JW. The use of inhaled corticosteroids in chronically ventilated preterm infants. Semin Fetal Neonatal Med. 2017 Oct; 22: 296-301.

                


                  Shepherd EG, Nelin LD. Preterm Birth, Bronchopulmonary Dysplasia, and Long-Term Respiratory Disease. Am J Respir Crit Care Med. 2017 Aug 1; 196: 264-265.

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 05/23/2003

Board Certifications

Neonatal-Perinatal Medicine

Fellowship

Baylor College of Medicine

Date Completed: 06/30/1988

Residency

Uppsala University

Date Completed: 01/01/1986

Residency

Baylor College of Medicine

Date Completed: 06/30/1985

Internship

Baylor College of Medicine

Date Completed: 06/30/1983

Medical School

University of South Florida

Date Completed: 06/12/1982

Professional Experience

2010 - Present Division of Neonatology, The Ohio State University, Interim Chief2007 - Present Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Director2002 - Present Department of Pediatrics, Ohio State University, Associate Professor2006 - 2007 Center for Perinatal Research, Nationwide Children’s Research Institute, Interim Director2002 - 2006 Center for Developmental Pharmacology and Toxicology, Columbus Children’s Research Institute, Investigator1998 - 2002 Department of Pediatrics, University of New Mexico, Associate Professor1994 - 1998 Department of Pediatrics, Medical College of Wisconsin, Associate Professor1994 - 1998 Biomedical engineering Department, Marquette University, Adjunct Associate Professor1989 - 1994 Department of Pediatrics, Medical College of Wisconsin, Assistant Professor

Contact Information

Pediatrics

Call us at: (614) 722-4559

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-4559

Fax us at: (614) 722-4541

PediatricsNeonatology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Leif D. Nelin

Contact Information

• Call us at:
• (614) 722-4559
• Fax us at:
• (614) 722-4541
• PediatricsNeonatology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Leif D. Nelin

Biography

Dr. Nelin is the Division Chief of Neonatology at Nationwide Children’s Hospital, Dean Jeffers Endowed Chair in Neonatology and a Professor of Pediatrics at The Ohio State University College of Medicine. Clinically, Dr. Nelin is particularly interested in respiratory diseases, specifically in how pulmonary blood flow affects newborn respiratory diseases. Thus, persistent pulmonary hypertension of the newborn(PPHN) is one of his primary clinical interests. This has lead to his research interest in nitric oxide (NO), a potent vasodilator whose production is decreased in patients with PPHN. Utilizing cell culture techniques, isolated perfused lungs and animal preparations, Dr. Nelin studies the mechanisms that determine biological availability of the amino acid L-arginine on the ability of the lungs to produce NO and thereby regulate blood flow. The ultimate goal of this research is to understand the pathophysiology of PPHN and to develop new and specific therapies for the treatment of lung diseases that are characterized by alterations in NO production. A second area of research interest is the study of the developmental toxicology of inhaled NO.

Biography

Dr. Nelin is the Division Chief of Neonatology at Nationwide Children’s Hospital, Dean Jeffers Endowed Chair in Neonatology and a Professor of Pediatrics at The Ohio State University College of Medicine. Clinically, Dr. Nelin is particularly interested in respiratory diseases, specifically in how pulmonary blood flow affects newborn respiratory diseases. Thus, persistent pulmonary hypertension of the newborn(PPHN) is one of his primary clinical interests. This has lead to his research interest in nitric oxide (NO), a potent vasodilator whose production is decreased in patients with PPHN. Utilizing cell culture techniques, isolated perfused lungs and animal preparations, Dr. Nelin studies the mechanisms that determine biological availability of the amino acid L-arginine on the ability of the lungs to produce NO and thereby regulate blood flow. The ultimate goal of this research is to understand the pathophysiology of PPHN and to develop new and specific therapies for the treatment of lung diseases that are characterized by alterations in NO production. A second area of research interest is the study of the developmental toxicology of inhaled NO.

Biography

Dr. Nelin is the Division Chief of Neonatology at Nationwide Children’s Hospital, Dean Jeffers Endowed Chair in Neonatology and a Professor of Pediatrics at The Ohio State University College of Medicine. Clinically, Dr. Nelin is particularly interested in respiratory diseases, specifically in how pulmonary blood flow affects newborn respiratory diseases. Thus, persistent pulmonary hypertension of the newborn(PPHN) is one of his primary clinical interests. This has lead to his research interest in nitric oxide (NO), a potent vasodilator whose production is decreased in patients with PPHN. Utilizing cell culture techniques, isolated perfused lungs and animal preparations, Dr. Nelin studies the mechanisms that determine biological availability of the amino acid L-arginine on the ability of the lungs to produce NO and thereby regulate blood flow. The ultimate goal of this research is to understand the pathophysiology of PPHN and to develop new and specific therapies for the treatment of lung diseases that are characterized by alterations in NO production. A second area of research interest is the study of the developmental toxicology of inhaled NO.

Dr. Nelin is the Division Chief of Neonatology at Nationwide Children’s Hospital, Dean Jeffers Endowed Chair in Neonatology and a Professor of Pediatrics at The Ohio State University College of Medicine. Clinically, Dr. Nelin is particularly interested in respiratory diseases, specifically in how pulmonary blood flow affects newborn respiratory diseases. Thus, persistent pulmonary hypertension of the newborn(PPHN) is one of his primary clinical interests. This has lead to his research interest in nitric oxide (NO), a potent vasodilator whose production is decreased in patients with PPHN. Utilizing cell culture techniques, isolated perfused lungs and animal preparations, Dr. Nelin studies the mechanisms that determine biological availability of the amino acid L-arginine on the ability of the lungs to produce NO and thereby regulate blood flow. The ultimate goal of this research is to understand the pathophysiology of PPHN and to develop new and specific therapies for the treatment of lung diseases that are characterized by alterations in NO production. A second area of research interest is the study of the developmental toxicology of inhaled NO.

Dr. Nelin is the Division Chief of Neonatology at Nationwide Children’s Hospital, Dean Jeffers Endowed Chair in Neonatology and a Professor of Pediatrics at The Ohio State University College of Medicine.

Clinically, Dr. Nelin is particularly interested in respiratory diseases, specifically in how pulmonary blood flow affects newborn respiratory diseases. Thus, persistent pulmonary hypertension of the newborn(PPHN) is one of his primary clinical interests. This has lead to his research interest in nitric oxide (NO), a potent vasodilator whose production is decreased in patients with PPHN. Utilizing cell culture techniques, isolated perfused lungs and animal preparations, Dr. Nelin studies the mechanisms that determine biological availability of the amino acid L-arginine on the ability of the lungs to produce NO and thereby regulate blood flow. The ultimate goal of this research is to understand the pathophysiology of PPHN and to develop new and specific therapies for the treatment of lung diseases that are characterized by alterations in NO production. A second area of research interest is the study of the developmental toxicology of inhaled NO.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Swedish

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Swedish

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Swedish

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Swedish

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Swedish

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Swedish

• Main Campus of Nationwide Children’s Hospital

• English

• Swedish

Academic and Clinical Areas

Neonatology

Division Chief

Center for Perinatal Research

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Neonatology

Academic and Clinical Areas

Neonatology

Division Chief

Center for Perinatal Research

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Neonatology

Academic and Clinical Areas

Neonatology

Division Chief

Center for Perinatal Research

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Neonatology

Neonatology

Division Chief

Center for Perinatal Research

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Neonatology

• Neonatology
• Division Chief
• Center for Perinatal Research
• Principal Investigator
• Neonatology Fellowship
• Faculty
• Primary Department
• Pediatrics
• Primary Section
• Neonatology

Awards, Honors & Organizations

Listed, Best Doctors in America

Awards, Honors & Organizations

Listed, Best Doctors in America

Awards, Honors & Organizations

Listed, Best Doctors in America

Listed, Best Doctors in America

• Listed, Best Doctors in America

Research

Lab(s)

Center for Perinatal Research

The research focus in Leif Nelin’s laboratory is on the elucidation of the functional and mechanistic aspects of cellular uptake of L-arginine by the cationic amino acid transporters (CAT) and the role of CAT activities and expression in regulation of nitric oxide (NO) production in the lung. Furthermore, they are studying the regulation of nitric oxide synthase and arginase induction in models of pulmonary hypertension and lung injury to develop strategies to influence arginine metabolism inside of the cell. Experiments are carried out in cell culture systems and animal models using pharmacological and genetic manipulations with experimental end-points ranging from biochemical assays, protein and mRNA assays, to functional and physiological measurements. The long-term goals of these studies are to develop therapies that increase NO production by facilitating CAT-mediated L-arg uptake in pulmonary hypertensive diseases, and that decrease NO production by inhibiting CAT-mediated L-arg uptake in inflammatory lung diseases. Publications

                  Nelin LD, Shepherd EG. Bones and lungs: insights from mice with fragile bones. J Physiol. 2022 Dec 14;  

                


                  Fortney CA, Baughcum AE, Garcia D, Winning AM, Humphrey L, Cistone N, Moscato EL, Keim MC, Nelin LD, Gerhardt CA. Characteristics of Critically Ill Infants at the End of Life in the Neonatal Intensive Care Unit. J Palliat Med. 2022 Dec 8;  

                


                  Cristea AI, Tracy MC, Bauer SE, Guaman MC, Welty SE, Baker CD, Bhombal S, Collaco JM, Courtney SE, DiGeronimo RJ, Eldredge LC, Gibbs K, Hayden LP, Keszler M, Lai K, McGrath-Morrow SA, Moore PE, Rose R, Sindelar R, Truog WE, Nelin LD, Abman S, BPD Collaborative. Approaches to Interdisciplinary Care for Infants with Severe Bronchopulmonary Dysplasia: A Survey of the Bronchopulmonary Dysplasia Collaborative. Am J Perinatol. 2022 Dec 7;  

                


                  Levin JC, Annesi CA, Williams DN, Abman SH, McGrath-Morrow SA, Nelin LD, Sheils CA, Hayden LP, Bronchopulmonary Dysplasia Collaborative Expert Panel on Discharge Practices.. Discharge Practices for Infants with Bronchopulmonary Dysplasia: A Survey of National Experts. J Pediatr. 2022 Sep 17;  

                


                  Lewis TR, Kielt MJ, Walker VP, Levin JC, Guaman MC, Panitch HB, Nelin LD, Abman SH, Bronchopulmonary Dysplasia Collaborative.. Association of Racial Disparities With In-Hospital Outcomes in Severe Bronchopulmonary Dysplasia. JAMA Pediatr. 2022 Aug 1;  

                


                  McGrath-Morrow SA, Agarwal A, Alexiou S, Austin ED, Fierro JL, Hayden LP, Lai K, Levin JC, Manimtim WM, Moore PE, Rhein LM, Rice JL, Sheils CA, Tracy MC, Bansal M, Baker CD, Cristea AI, Popova AP, Siddaiah R, Villafranco N, Nelin LD, Collaco JM. Daycare Attendance is linked to Increased Risk of Respiratory Morbidities in Preterm Children with Bronchopulmonary Dysplasia. J Pediatr. 2022 Jul 5;  

                


                  Nelin LD, Kielt MJ, Jebbia M, Jadcherla S, Shepherd EG. Bronchodilator responsiveness and dysanapsis in bronchopulmonary dysplasia. ERJ Open Res. 2022 Jul; 8: 

                


                  Miller CJ, Prusakov P, Magers J, Speaks S, Sacic H, Escobar K, Abdel-Rasoul M, Nelin LD. Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit. J Perinatol. 2022 Jun 25;  

                


                  Chen B, Jin Y, Pool CM, Liu Y, Nelin LD. Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation. Physiol Rep. 2022 Jun; 10: e15342.

                


                  Collaco JM, Tracy MC, Sheils CA, Rice JL, Rhein LM, Nelin LD, Moore PE, Manimtim WM, Levin JC, Lai K, Hayden LP, Fierro JL, Austin ED, Alexiou S, Agarwal A, Villafranco N, Siddaiah R, Popova AP, Cristea IA, Baker CD, Bansal M, McGrath-Morrow SA. Insurance coverage and respiratory morbidities in bronchopulmonary dysplasia. Pediatr Pulmonol. 2022 Apr 18;  

                


                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Logan JW, Bapat R, Ryshen G, Bagwell G, Eisner M, Kielt M, Hanawalt M, Payne K, Alt-Coan A, Tatad M, Krendl D, Jebbia M, Reber KM, Halling C, Osman AA, Bonachea EM, Nelin LD, Fathi O. Use of a quality scorecard to enhance quality and safety in community hospital newborn nurseries. J Pediatr. 2022 Mar 28;  

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Lee CD, Nelin L, Foglia EE. Neonatal Resuscitation in 22-Week Pregnancies. N Engl J Med. 2022 Jan 27; 386: 391-393.

                


                  Miller AN, Kielt MJ, El-Ferzli GT, Nelin LD, Shepherd EG. Optimizing ventilator support in severe bronchopulmonary dysplasia in the absence of conclusive evidence. Front Pediatr. 2022; 10: 1022743.

                


                  Sindelar R, Shepherd EG, Ågren J, Panitch HB, Abman SH, Nelin LD, Bronchopulmonary Dysplasia Collaborative.. Established severe BPD: is there a way out? Change of ventilatory paradigms. Pediatr Res. 2021 Dec; 90: 1139-1146.

                


                  Pavlek LR, Mueller C, Jebbia MR, Kielt MJ, Nelin LD, Shepherd EG, Reber KM, Fathi O. Perspectives on developing and sustaining a small baby program. Semin Perinatol. 2021 Nov 10;  151548.

                


                  Trittmann JK, Almazroue H, Nelin LD, Shaffer TA, Celestine CR, Green HW 3rd, Malbrue RA. PATET ratio by Doppler echocardiography: noninvasive detection of pediatric pulmonary arterial hypertension. Pediatr Res. 2021 Nov 18;  

                


                  Kielt MJ, Logan JW, Backes CH, Conroy S, Reber KM, Shepherd EG, Nelin LD. Noninvasive Respiratory Severity Indices Predict Adverse Outcomes in Bronchopulmonary Dysplasia. J Pediatr. 2021 Nov 11;  

                


                  Yallapragada S, Savani RC, Munoz-Blanco S, Lagatta JM, Truog WE, Porta NFM, Nelin LD, Zhang H, Vyas-Read S, DiGeronimo R, Natarajan G, Wymore E, Haberman B, Machry J, Potoka K, Children’s Hospital Neonatal Consortium severe bronchopulmonary dysplasia subgroup., Murthy K. Qualitative indications for tracheostomy and chronic mechanical ventilation in patients with severe bronchopulmonary dysplasia. J Perinatol. 2021 Nov; 41: 2651-2657.

                


                  Kielt MJ, Murphy A, Smathers J, Bates M, Nelin LD, Shepherd EG. In-Hospital Respiratory Viral Infections for Patients with Established BPD in the SARS-CoV-2 Era. Pediatr Pulmonol. 2021 Oct 1;  

                


                  Nelin L, Kinsella JP, Courtney SE, Pallotto EK, Tarau E, Potenziano JL. Use of inhaled nitric oxide in preterm vs term/near-term neonates with pulmonary hypertension: results of the PaTTerN registry study. J Perinatol. 2021 Oct 28;  

                


                  Vyas-Read S, Logan JW, Cuna AC, Machry J, Leeman KT, Rose RS, Mikhael M, Wymore E, Ibrahim JW, DiGeronimo RJ, Yallapragada S, Haberman BE, Padula MA, Porta NF, Murthy K, Nelin LD, Coghill CH, Zaniletti I, Savani RC, Truog W, Engle WA, Lagatta JM. A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children's Hospitals Neonatal Consortium Severe BPD Group. J Perinatol. 2021 Aug 5;  

                


                  Guaman MC, Pishevar N, Abman SH, Keszler M, Truog WE, Panitch H, Nelin LD. Invasive mechanical ventilation at 36 weeks post-menstrual age, adverse outcomes with a comparison of recent definitions of bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1936-1942.

                


                  Kielt MJ, Logan JW, Backes CH, Reber KM, Nelin LD, Shepherd EG. In-hospital outcomes of late referrals for established bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1972-1982.

                


                  Hoffsten A, Markasz L, Ericson K, Nelin LD, Sindelar R. The value of autopsy in preterm infants at a Swedish tertiary neonatal intensive care unit 2002-2018. Sci Rep. 2021 Jul 8; 11: 14156.

                


                  Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  

                


                  Collaco JM, Agarwal A, Austin ED, Hayden LP, Lai K, Levin J, Manimtim WM, Moore PE, Sheils CA, Tracy MC, Alexiou S, Baker CD, Cristea AI, Fierro JL, Rhein LM, Villafranco N, Nelin LD, McGrath-Morrow SA. Characteristics of infants or children presenting to outpatient bronchopulmonary dysplasia clinics in the United States. Pediatr Pulmonol. 2021 Jun; 56: 1617-1625.

                


                  Fathi O, Nelin LD, Shepherd EG, Reber KM. Development of a small baby unit to improve outcomes for the extremely premature infant. J Perinatol. 2021 Mar 12;  

                


                  Stewart WCL, Gnona KM, White P, Kelly B, Klebanoff M, Buhimschi IA, Nelin LD. Prediction of short-term neonatal complications in preterm infants using exome-wide genetic variation and gestational age: a pilot study. Pediatr Res. 2020 Oct; 88: 653-660.

                


                  Pishevar N, Fathi O, Backes CH, Shepherd EG, Nelin LD. Predicting survival in infants born at <27 weeks gestation admitted to an all referral neonatal intensive care unit: a pilot study. J Perinatol. 2020 May; 40: 750-757.

                


                  Bapat R, Nelin L, Shepherd E, Ryshen G, Elgin A, Bartman T. A multidisciplinary quality improvement effort to reduce bronchopulmonary dysplasia incidence. J Perinatol. 2020 Apr; 40: 681-687.

                


                  Bauer SE, Schneider L, Lynch SK, Malleske DT, Shepherd EG, Nelin LD. Factors Associated with Neurodevelopmental Impairment in Bronchopulmonary Dysplasia. J Pediatr. 2020 Jan 8;  

                


                  Vyas-Read S, Wymore EM, Zaniletti I, Murthy K, Padula MA, Truog WE, Engle WA, Savani RC, Yallapragada S, Logan JW, Zhang H, Hysinger EB, Grover TR, Natarajan G, Nelin LD, Porta NFM, Potoka KP, DiGeronimo R, Lagatta JM, Children’s Hospitals Neonatal Consortium Severe BPD Focus Group.. Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia. J Perinatol. 2019 Sep 30;  

                


                  Trittmann JK, Almazroue H, Jin Y, Nelin LD. DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells. Physiol Rep. 2019 Jul; 7: e14150.

                


                  Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.

                


                  Nelin LD, Potenziano JL. Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response. BMC Pediatr. 2019 Jan 12; 19: 17.

                


                  Backes CH, Söderström F, Ågren J, Sindelar R, Bartlett CW, Rivera BK, Mitchell CC, Frey HA, Shepherd EG, Nelin LD, Normann E. Outcomes following a comprehensive versus a selective approach for infants born at 22 weeks of gestation. J Perinatol. 2019 Jan; 39: 39-47.

                


                  Li J, Wang X, Ackerman WE 4th, Batty AJ, Kirk SG, White WM, Wang X, Anastasakis D, Samavati L, Buhimschi I, Nelin LD, Hafner M, Liu Y. Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis. Int J Mol Sci. 2018 Dec 6; 19: 

                


                  Zhang H, Dysart K, Kendrick DE, Li L, Das A, Hintz SR, Vohr BR, Stoll BJ, Higgins RD, Nelin L, Carlton DP, Walsh MC, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Prolonged respiratory support of any type impacts outcomes of extremely low birth weight infants. Pediatr Pulmonol. 2018 Oct; 53: 1447-1455.

                


                  Lagatta JM, Hysinger EB, Zaniletti I, Wymore EM, Vyas-Read S, Yallapragada S, Nelin LD, Truog WE, Padula MA, Porta NFM, Savani RC, Potoka KP, Kawut SM, DiGeronimo R, Natarajan G, Zhang H, Grover TR, Engle WA, Murthy K, Children's Hospital Neonatal Consortium Severe BPD Focus Group.. The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year. J Pediatr. 2018 Aug 29;  

                


                  Nelin TD, Shepherd EG, Nelin LD. In Response to Letter from Altit, Basso, Grandi, and Yang. J Perinatol. 2018 Jun; 38: 768.

                


                  Trittmann JK, Velten M, Heyob KM, Almazroue H, Jin Y, Nelin LD, Rogers LK. Arginase and a-smooth muscle actin induction after hyperoxic exposure in a mouse model of bronchopulmonary dysplasia. Clin Exp Pharmacol Physiol. 2018 Jun; 45: 556-562.

                


                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

                


                  Nelin LD, Shepherd EG. Disappointing results: a call to action. J Thorac Dis. 2018 Feb; 10: 631-633.

                


                  James J, Munson D, DeMauro SB, Langer JC, Dworetz AR, Natarajan G, Bidegain M, Fortney CA, Seabrook R, Vohr BR, Tyson JE, Bell EF, Poindexter BB, Shankaran S, Higgins RD, Das A, Stoll BJ, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr. 2017 Nov; 190: 118-123.e4.

                


                  Nelin LD, Logan JW. The use of inhaled corticosteroids in chronically ventilated preterm infants. Semin Fetal Neonatal Med. 2017 Oct; 22: 296-301.

                


                  Shepherd EG, Nelin LD. Preterm Birth, Bronchopulmonary Dysplasia, and Long-Term Respiratory Disease. Am J Respir Crit Care Med. 2017 Aug 1; 196: 264-265.

View More Publications

Research

Lab(s)

Center for Perinatal Research

The research focus in Leif Nelin’s laboratory is on the elucidation of the functional and mechanistic aspects of cellular uptake of L-arginine by the cationic amino acid transporters (CAT) and the role of CAT activities and expression in regulation of nitric oxide (NO) production in the lung. Furthermore, they are studying the regulation of nitric oxide synthase and arginase induction in models of pulmonary hypertension and lung injury to develop strategies to influence arginine metabolism inside of the cell. Experiments are carried out in cell culture systems and animal models using pharmacological and genetic manipulations with experimental end-points ranging from biochemical assays, protein and mRNA assays, to functional and physiological measurements. The long-term goals of these studies are to develop therapies that increase NO production by facilitating CAT-mediated L-arg uptake in pulmonary hypertensive diseases, and that decrease NO production by inhibiting CAT-mediated L-arg uptake in inflammatory lung diseases. Publications

                  Nelin LD, Shepherd EG. Bones and lungs: insights from mice with fragile bones. J Physiol. 2022 Dec 14;  

                


                  Fortney CA, Baughcum AE, Garcia D, Winning AM, Humphrey L, Cistone N, Moscato EL, Keim MC, Nelin LD, Gerhardt CA. Characteristics of Critically Ill Infants at the End of Life in the Neonatal Intensive Care Unit. J Palliat Med. 2022 Dec 8;  

                


                  Cristea AI, Tracy MC, Bauer SE, Guaman MC, Welty SE, Baker CD, Bhombal S, Collaco JM, Courtney SE, DiGeronimo RJ, Eldredge LC, Gibbs K, Hayden LP, Keszler M, Lai K, McGrath-Morrow SA, Moore PE, Rose R, Sindelar R, Truog WE, Nelin LD, Abman S, BPD Collaborative. Approaches to Interdisciplinary Care for Infants with Severe Bronchopulmonary Dysplasia: A Survey of the Bronchopulmonary Dysplasia Collaborative. Am J Perinatol. 2022 Dec 7;  

                


                  Levin JC, Annesi CA, Williams DN, Abman SH, McGrath-Morrow SA, Nelin LD, Sheils CA, Hayden LP, Bronchopulmonary Dysplasia Collaborative Expert Panel on Discharge Practices.. Discharge Practices for Infants with Bronchopulmonary Dysplasia: A Survey of National Experts. J Pediatr. 2022 Sep 17;  

                


                  Lewis TR, Kielt MJ, Walker VP, Levin JC, Guaman MC, Panitch HB, Nelin LD, Abman SH, Bronchopulmonary Dysplasia Collaborative.. Association of Racial Disparities With In-Hospital Outcomes in Severe Bronchopulmonary Dysplasia. JAMA Pediatr. 2022 Aug 1;  

                


                  McGrath-Morrow SA, Agarwal A, Alexiou S, Austin ED, Fierro JL, Hayden LP, Lai K, Levin JC, Manimtim WM, Moore PE, Rhein LM, Rice JL, Sheils CA, Tracy MC, Bansal M, Baker CD, Cristea AI, Popova AP, Siddaiah R, Villafranco N, Nelin LD, Collaco JM. Daycare Attendance is linked to Increased Risk of Respiratory Morbidities in Preterm Children with Bronchopulmonary Dysplasia. J Pediatr. 2022 Jul 5;  

                


                  Nelin LD, Kielt MJ, Jebbia M, Jadcherla S, Shepherd EG. Bronchodilator responsiveness and dysanapsis in bronchopulmonary dysplasia. ERJ Open Res. 2022 Jul; 8: 

                


                  Miller CJ, Prusakov P, Magers J, Speaks S, Sacic H, Escobar K, Abdel-Rasoul M, Nelin LD. Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit. J Perinatol. 2022 Jun 25;  

                


                  Chen B, Jin Y, Pool CM, Liu Y, Nelin LD. Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation. Physiol Rep. 2022 Jun; 10: e15342.

                


                  Collaco JM, Tracy MC, Sheils CA, Rice JL, Rhein LM, Nelin LD, Moore PE, Manimtim WM, Levin JC, Lai K, Hayden LP, Fierro JL, Austin ED, Alexiou S, Agarwal A, Villafranco N, Siddaiah R, Popova AP, Cristea IA, Baker CD, Bansal M, McGrath-Morrow SA. Insurance coverage and respiratory morbidities in bronchopulmonary dysplasia. Pediatr Pulmonol. 2022 Apr 18;  

                


                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Logan JW, Bapat R, Ryshen G, Bagwell G, Eisner M, Kielt M, Hanawalt M, Payne K, Alt-Coan A, Tatad M, Krendl D, Jebbia M, Reber KM, Halling C, Osman AA, Bonachea EM, Nelin LD, Fathi O. Use of a quality scorecard to enhance quality and safety in community hospital newborn nurseries. J Pediatr. 2022 Mar 28;  

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Lee CD, Nelin L, Foglia EE. Neonatal Resuscitation in 22-Week Pregnancies. N Engl J Med. 2022 Jan 27; 386: 391-393.

                


                  Miller AN, Kielt MJ, El-Ferzli GT, Nelin LD, Shepherd EG. Optimizing ventilator support in severe bronchopulmonary dysplasia in the absence of conclusive evidence. Front Pediatr. 2022; 10: 1022743.

                


                  Sindelar R, Shepherd EG, Ågren J, Panitch HB, Abman SH, Nelin LD, Bronchopulmonary Dysplasia Collaborative.. Established severe BPD: is there a way out? Change of ventilatory paradigms. Pediatr Res. 2021 Dec; 90: 1139-1146.

                


                  Pavlek LR, Mueller C, Jebbia MR, Kielt MJ, Nelin LD, Shepherd EG, Reber KM, Fathi O. Perspectives on developing and sustaining a small baby program. Semin Perinatol. 2021 Nov 10;  151548.

                


                  Trittmann JK, Almazroue H, Nelin LD, Shaffer TA, Celestine CR, Green HW 3rd, Malbrue RA. PATET ratio by Doppler echocardiography: noninvasive detection of pediatric pulmonary arterial hypertension. Pediatr Res. 2021 Nov 18;  

                


                  Kielt MJ, Logan JW, Backes CH, Conroy S, Reber KM, Shepherd EG, Nelin LD. Noninvasive Respiratory Severity Indices Predict Adverse Outcomes in Bronchopulmonary Dysplasia. J Pediatr. 2021 Nov 11;  

                


                  Yallapragada S, Savani RC, Munoz-Blanco S, Lagatta JM, Truog WE, Porta NFM, Nelin LD, Zhang H, Vyas-Read S, DiGeronimo R, Natarajan G, Wymore E, Haberman B, Machry J, Potoka K, Children’s Hospital Neonatal Consortium severe bronchopulmonary dysplasia subgroup., Murthy K. Qualitative indications for tracheostomy and chronic mechanical ventilation in patients with severe bronchopulmonary dysplasia. J Perinatol. 2021 Nov; 41: 2651-2657.

                


                  Kielt MJ, Murphy A, Smathers J, Bates M, Nelin LD, Shepherd EG. In-Hospital Respiratory Viral Infections for Patients with Established BPD in the SARS-CoV-2 Era. Pediatr Pulmonol. 2021 Oct 1;  

                


                  Nelin L, Kinsella JP, Courtney SE, Pallotto EK, Tarau E, Potenziano JL. Use of inhaled nitric oxide in preterm vs term/near-term neonates with pulmonary hypertension: results of the PaTTerN registry study. J Perinatol. 2021 Oct 28;  

                


                  Vyas-Read S, Logan JW, Cuna AC, Machry J, Leeman KT, Rose RS, Mikhael M, Wymore E, Ibrahim JW, DiGeronimo RJ, Yallapragada S, Haberman BE, Padula MA, Porta NF, Murthy K, Nelin LD, Coghill CH, Zaniletti I, Savani RC, Truog W, Engle WA, Lagatta JM. A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children's Hospitals Neonatal Consortium Severe BPD Group. J Perinatol. 2021 Aug 5;  

                


                  Guaman MC, Pishevar N, Abman SH, Keszler M, Truog WE, Panitch H, Nelin LD. Invasive mechanical ventilation at 36 weeks post-menstrual age, adverse outcomes with a comparison of recent definitions of bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1936-1942.

                


                  Kielt MJ, Logan JW, Backes CH, Reber KM, Nelin LD, Shepherd EG. In-hospital outcomes of late referrals for established bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1972-1982.

                


                  Hoffsten A, Markasz L, Ericson K, Nelin LD, Sindelar R. The value of autopsy in preterm infants at a Swedish tertiary neonatal intensive care unit 2002-2018. Sci Rep. 2021 Jul 8; 11: 14156.

                


                  Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  

                


                  Collaco JM, Agarwal A, Austin ED, Hayden LP, Lai K, Levin J, Manimtim WM, Moore PE, Sheils CA, Tracy MC, Alexiou S, Baker CD, Cristea AI, Fierro JL, Rhein LM, Villafranco N, Nelin LD, McGrath-Morrow SA. Characteristics of infants or children presenting to outpatient bronchopulmonary dysplasia clinics in the United States. Pediatr Pulmonol. 2021 Jun; 56: 1617-1625.

                


                  Fathi O, Nelin LD, Shepherd EG, Reber KM. Development of a small baby unit to improve outcomes for the extremely premature infant. J Perinatol. 2021 Mar 12;  

                


                  Stewart WCL, Gnona KM, White P, Kelly B, Klebanoff M, Buhimschi IA, Nelin LD. Prediction of short-term neonatal complications in preterm infants using exome-wide genetic variation and gestational age: a pilot study. Pediatr Res. 2020 Oct; 88: 653-660.

                


                  Pishevar N, Fathi O, Backes CH, Shepherd EG, Nelin LD. Predicting survival in infants born at <27 weeks gestation admitted to an all referral neonatal intensive care unit: a pilot study. J Perinatol. 2020 May; 40: 750-757.

                


                  Bapat R, Nelin L, Shepherd E, Ryshen G, Elgin A, Bartman T. A multidisciplinary quality improvement effort to reduce bronchopulmonary dysplasia incidence. J Perinatol. 2020 Apr; 40: 681-687.

                


                  Bauer SE, Schneider L, Lynch SK, Malleske DT, Shepherd EG, Nelin LD. Factors Associated with Neurodevelopmental Impairment in Bronchopulmonary Dysplasia. J Pediatr. 2020 Jan 8;  

                


                  Vyas-Read S, Wymore EM, Zaniletti I, Murthy K, Padula MA, Truog WE, Engle WA, Savani RC, Yallapragada S, Logan JW, Zhang H, Hysinger EB, Grover TR, Natarajan G, Nelin LD, Porta NFM, Potoka KP, DiGeronimo R, Lagatta JM, Children’s Hospitals Neonatal Consortium Severe BPD Focus Group.. Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia. J Perinatol. 2019 Sep 30;  

                


                  Trittmann JK, Almazroue H, Jin Y, Nelin LD. DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells. Physiol Rep. 2019 Jul; 7: e14150.

                


                  Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.

                


                  Nelin LD, Potenziano JL. Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response. BMC Pediatr. 2019 Jan 12; 19: 17.

                


                  Backes CH, Söderström F, Ågren J, Sindelar R, Bartlett CW, Rivera BK, Mitchell CC, Frey HA, Shepherd EG, Nelin LD, Normann E. Outcomes following a comprehensive versus a selective approach for infants born at 22 weeks of gestation. J Perinatol. 2019 Jan; 39: 39-47.

                


                  Li J, Wang X, Ackerman WE 4th, Batty AJ, Kirk SG, White WM, Wang X, Anastasakis D, Samavati L, Buhimschi I, Nelin LD, Hafner M, Liu Y. Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis. Int J Mol Sci. 2018 Dec 6; 19: 

                


                  Zhang H, Dysart K, Kendrick DE, Li L, Das A, Hintz SR, Vohr BR, Stoll BJ, Higgins RD, Nelin L, Carlton DP, Walsh MC, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Prolonged respiratory support of any type impacts outcomes of extremely low birth weight infants. Pediatr Pulmonol. 2018 Oct; 53: 1447-1455.

                


                  Lagatta JM, Hysinger EB, Zaniletti I, Wymore EM, Vyas-Read S, Yallapragada S, Nelin LD, Truog WE, Padula MA, Porta NFM, Savani RC, Potoka KP, Kawut SM, DiGeronimo R, Natarajan G, Zhang H, Grover TR, Engle WA, Murthy K, Children's Hospital Neonatal Consortium Severe BPD Focus Group.. The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year. J Pediatr. 2018 Aug 29;  

                


                  Nelin TD, Shepherd EG, Nelin LD. In Response to Letter from Altit, Basso, Grandi, and Yang. J Perinatol. 2018 Jun; 38: 768.

                


                  Trittmann JK, Velten M, Heyob KM, Almazroue H, Jin Y, Nelin LD, Rogers LK. Arginase and a-smooth muscle actin induction after hyperoxic exposure in a mouse model of bronchopulmonary dysplasia. Clin Exp Pharmacol Physiol. 2018 Jun; 45: 556-562.

                


                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

                


                  Nelin LD, Shepherd EG. Disappointing results: a call to action. J Thorac Dis. 2018 Feb; 10: 631-633.

                


                  James J, Munson D, DeMauro SB, Langer JC, Dworetz AR, Natarajan G, Bidegain M, Fortney CA, Seabrook R, Vohr BR, Tyson JE, Bell EF, Poindexter BB, Shankaran S, Higgins RD, Das A, Stoll BJ, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr. 2017 Nov; 190: 118-123.e4.

                


                  Nelin LD, Logan JW. The use of inhaled corticosteroids in chronically ventilated preterm infants. Semin Fetal Neonatal Med. 2017 Oct; 22: 296-301.

                


                  Shepherd EG, Nelin LD. Preterm Birth, Bronchopulmonary Dysplasia, and Long-Term Respiratory Disease. Am J Respir Crit Care Med. 2017 Aug 1; 196: 264-265.

View More Publications

Research

Lab(s)

Center for Perinatal Research

The research focus in Leif Nelin’s laboratory is on the elucidation of the functional and mechanistic aspects of cellular uptake of L-arginine by the cationic amino acid transporters (CAT) and the role of CAT activities and expression in regulation of nitric oxide (NO) production in the lung. Furthermore, they are studying the regulation of nitric oxide synthase and arginase induction in models of pulmonary hypertension and lung injury to develop strategies to influence arginine metabolism inside of the cell. Experiments are carried out in cell culture systems and animal models using pharmacological and genetic manipulations with experimental end-points ranging from biochemical assays, protein and mRNA assays, to functional and physiological measurements. The long-term goals of these studies are to develop therapies that increase NO production by facilitating CAT-mediated L-arg uptake in pulmonary hypertensive diseases, and that decrease NO production by inhibiting CAT-mediated L-arg uptake in inflammatory lung diseases. Publications

                  Nelin LD, Shepherd EG. Bones and lungs: insights from mice with fragile bones. J Physiol. 2022 Dec 14;  

                


                  Fortney CA, Baughcum AE, Garcia D, Winning AM, Humphrey L, Cistone N, Moscato EL, Keim MC, Nelin LD, Gerhardt CA. Characteristics of Critically Ill Infants at the End of Life in the Neonatal Intensive Care Unit. J Palliat Med. 2022 Dec 8;  

                


                  Cristea AI, Tracy MC, Bauer SE, Guaman MC, Welty SE, Baker CD, Bhombal S, Collaco JM, Courtney SE, DiGeronimo RJ, Eldredge LC, Gibbs K, Hayden LP, Keszler M, Lai K, McGrath-Morrow SA, Moore PE, Rose R, Sindelar R, Truog WE, Nelin LD, Abman S, BPD Collaborative. Approaches to Interdisciplinary Care for Infants with Severe Bronchopulmonary Dysplasia: A Survey of the Bronchopulmonary Dysplasia Collaborative. Am J Perinatol. 2022 Dec 7;  

                


                  Levin JC, Annesi CA, Williams DN, Abman SH, McGrath-Morrow SA, Nelin LD, Sheils CA, Hayden LP, Bronchopulmonary Dysplasia Collaborative Expert Panel on Discharge Practices.. Discharge Practices for Infants with Bronchopulmonary Dysplasia: A Survey of National Experts. J Pediatr. 2022 Sep 17;  

                


                  Lewis TR, Kielt MJ, Walker VP, Levin JC, Guaman MC, Panitch HB, Nelin LD, Abman SH, Bronchopulmonary Dysplasia Collaborative.. Association of Racial Disparities With In-Hospital Outcomes in Severe Bronchopulmonary Dysplasia. JAMA Pediatr. 2022 Aug 1;  

                


                  McGrath-Morrow SA, Agarwal A, Alexiou S, Austin ED, Fierro JL, Hayden LP, Lai K, Levin JC, Manimtim WM, Moore PE, Rhein LM, Rice JL, Sheils CA, Tracy MC, Bansal M, Baker CD, Cristea AI, Popova AP, Siddaiah R, Villafranco N, Nelin LD, Collaco JM. Daycare Attendance is linked to Increased Risk of Respiratory Morbidities in Preterm Children with Bronchopulmonary Dysplasia. J Pediatr. 2022 Jul 5;  

                


                  Nelin LD, Kielt MJ, Jebbia M, Jadcherla S, Shepherd EG. Bronchodilator responsiveness and dysanapsis in bronchopulmonary dysplasia. ERJ Open Res. 2022 Jul; 8: 

                


                  Miller CJ, Prusakov P, Magers J, Speaks S, Sacic H, Escobar K, Abdel-Rasoul M, Nelin LD. Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit. J Perinatol. 2022 Jun 25;  

                


                  Chen B, Jin Y, Pool CM, Liu Y, Nelin LD. Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation. Physiol Rep. 2022 Jun; 10: e15342.

                


                  Collaco JM, Tracy MC, Sheils CA, Rice JL, Rhein LM, Nelin LD, Moore PE, Manimtim WM, Levin JC, Lai K, Hayden LP, Fierro JL, Austin ED, Alexiou S, Agarwal A, Villafranco N, Siddaiah R, Popova AP, Cristea IA, Baker CD, Bansal M, McGrath-Morrow SA. Insurance coverage and respiratory morbidities in bronchopulmonary dysplasia. Pediatr Pulmonol. 2022 Apr 18;  

                


                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Logan JW, Bapat R, Ryshen G, Bagwell G, Eisner M, Kielt M, Hanawalt M, Payne K, Alt-Coan A, Tatad M, Krendl D, Jebbia M, Reber KM, Halling C, Osman AA, Bonachea EM, Nelin LD, Fathi O. Use of a quality scorecard to enhance quality and safety in community hospital newborn nurseries. J Pediatr. 2022 Mar 28;  

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Lee CD, Nelin L, Foglia EE. Neonatal Resuscitation in 22-Week Pregnancies. N Engl J Med. 2022 Jan 27; 386: 391-393.

                


                  Miller AN, Kielt MJ, El-Ferzli GT, Nelin LD, Shepherd EG. Optimizing ventilator support in severe bronchopulmonary dysplasia in the absence of conclusive evidence. Front Pediatr. 2022; 10: 1022743.

                


                  Sindelar R, Shepherd EG, Ågren J, Panitch HB, Abman SH, Nelin LD, Bronchopulmonary Dysplasia Collaborative.. Established severe BPD: is there a way out? Change of ventilatory paradigms. Pediatr Res. 2021 Dec; 90: 1139-1146.

                


                  Pavlek LR, Mueller C, Jebbia MR, Kielt MJ, Nelin LD, Shepherd EG, Reber KM, Fathi O. Perspectives on developing and sustaining a small baby program. Semin Perinatol. 2021 Nov 10;  151548.

                


                  Trittmann JK, Almazroue H, Nelin LD, Shaffer TA, Celestine CR, Green HW 3rd, Malbrue RA. PATET ratio by Doppler echocardiography: noninvasive detection of pediatric pulmonary arterial hypertension. Pediatr Res. 2021 Nov 18;  

                


                  Kielt MJ, Logan JW, Backes CH, Conroy S, Reber KM, Shepherd EG, Nelin LD. Noninvasive Respiratory Severity Indices Predict Adverse Outcomes in Bronchopulmonary Dysplasia. J Pediatr. 2021 Nov 11;  

                


                  Yallapragada S, Savani RC, Munoz-Blanco S, Lagatta JM, Truog WE, Porta NFM, Nelin LD, Zhang H, Vyas-Read S, DiGeronimo R, Natarajan G, Wymore E, Haberman B, Machry J, Potoka K, Children’s Hospital Neonatal Consortium severe bronchopulmonary dysplasia subgroup., Murthy K. Qualitative indications for tracheostomy and chronic mechanical ventilation in patients with severe bronchopulmonary dysplasia. J Perinatol. 2021 Nov; 41: 2651-2657.

                


                  Kielt MJ, Murphy A, Smathers J, Bates M, Nelin LD, Shepherd EG. In-Hospital Respiratory Viral Infections for Patients with Established BPD in the SARS-CoV-2 Era. Pediatr Pulmonol. 2021 Oct 1;  

                


                  Nelin L, Kinsella JP, Courtney SE, Pallotto EK, Tarau E, Potenziano JL. Use of inhaled nitric oxide in preterm vs term/near-term neonates with pulmonary hypertension: results of the PaTTerN registry study. J Perinatol. 2021 Oct 28;  

                


                  Vyas-Read S, Logan JW, Cuna AC, Machry J, Leeman KT, Rose RS, Mikhael M, Wymore E, Ibrahim JW, DiGeronimo RJ, Yallapragada S, Haberman BE, Padula MA, Porta NF, Murthy K, Nelin LD, Coghill CH, Zaniletti I, Savani RC, Truog W, Engle WA, Lagatta JM. A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children's Hospitals Neonatal Consortium Severe BPD Group. J Perinatol. 2021 Aug 5;  

                


                  Guaman MC, Pishevar N, Abman SH, Keszler M, Truog WE, Panitch H, Nelin LD. Invasive mechanical ventilation at 36 weeks post-menstrual age, adverse outcomes with a comparison of recent definitions of bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1936-1942.

                


                  Kielt MJ, Logan JW, Backes CH, Reber KM, Nelin LD, Shepherd EG. In-hospital outcomes of late referrals for established bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1972-1982.

                


                  Hoffsten A, Markasz L, Ericson K, Nelin LD, Sindelar R. The value of autopsy in preterm infants at a Swedish tertiary neonatal intensive care unit 2002-2018. Sci Rep. 2021 Jul 8; 11: 14156.

                


                  Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  

                


                  Collaco JM, Agarwal A, Austin ED, Hayden LP, Lai K, Levin J, Manimtim WM, Moore PE, Sheils CA, Tracy MC, Alexiou S, Baker CD, Cristea AI, Fierro JL, Rhein LM, Villafranco N, Nelin LD, McGrath-Morrow SA. Characteristics of infants or children presenting to outpatient bronchopulmonary dysplasia clinics in the United States. Pediatr Pulmonol. 2021 Jun; 56: 1617-1625.

                


                  Fathi O, Nelin LD, Shepherd EG, Reber KM. Development of a small baby unit to improve outcomes for the extremely premature infant. J Perinatol. 2021 Mar 12;  

                


                  Stewart WCL, Gnona KM, White P, Kelly B, Klebanoff M, Buhimschi IA, Nelin LD. Prediction of short-term neonatal complications in preterm infants using exome-wide genetic variation and gestational age: a pilot study. Pediatr Res. 2020 Oct; 88: 653-660.

                


                  Pishevar N, Fathi O, Backes CH, Shepherd EG, Nelin LD. Predicting survival in infants born at <27 weeks gestation admitted to an all referral neonatal intensive care unit: a pilot study. J Perinatol. 2020 May; 40: 750-757.

                


                  Bapat R, Nelin L, Shepherd E, Ryshen G, Elgin A, Bartman T. A multidisciplinary quality improvement effort to reduce bronchopulmonary dysplasia incidence. J Perinatol. 2020 Apr; 40: 681-687.

                


                  Bauer SE, Schneider L, Lynch SK, Malleske DT, Shepherd EG, Nelin LD. Factors Associated with Neurodevelopmental Impairment in Bronchopulmonary Dysplasia. J Pediatr. 2020 Jan 8;  

                


                  Vyas-Read S, Wymore EM, Zaniletti I, Murthy K, Padula MA, Truog WE, Engle WA, Savani RC, Yallapragada S, Logan JW, Zhang H, Hysinger EB, Grover TR, Natarajan G, Nelin LD, Porta NFM, Potoka KP, DiGeronimo R, Lagatta JM, Children’s Hospitals Neonatal Consortium Severe BPD Focus Group.. Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia. J Perinatol. 2019 Sep 30;  

                


                  Trittmann JK, Almazroue H, Jin Y, Nelin LD. DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells. Physiol Rep. 2019 Jul; 7: e14150.

                


                  Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.

                


                  Nelin LD, Potenziano JL. Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response. BMC Pediatr. 2019 Jan 12; 19: 17.

                


                  Backes CH, Söderström F, Ågren J, Sindelar R, Bartlett CW, Rivera BK, Mitchell CC, Frey HA, Shepherd EG, Nelin LD, Normann E. Outcomes following a comprehensive versus a selective approach for infants born at 22 weeks of gestation. J Perinatol. 2019 Jan; 39: 39-47.

                


                  Li J, Wang X, Ackerman WE 4th, Batty AJ, Kirk SG, White WM, Wang X, Anastasakis D, Samavati L, Buhimschi I, Nelin LD, Hafner M, Liu Y. Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis. Int J Mol Sci. 2018 Dec 6; 19: 

                


                  Zhang H, Dysart K, Kendrick DE, Li L, Das A, Hintz SR, Vohr BR, Stoll BJ, Higgins RD, Nelin L, Carlton DP, Walsh MC, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Prolonged respiratory support of any type impacts outcomes of extremely low birth weight infants. Pediatr Pulmonol. 2018 Oct; 53: 1447-1455.

                


                  Lagatta JM, Hysinger EB, Zaniletti I, Wymore EM, Vyas-Read S, Yallapragada S, Nelin LD, Truog WE, Padula MA, Porta NFM, Savani RC, Potoka KP, Kawut SM, DiGeronimo R, Natarajan G, Zhang H, Grover TR, Engle WA, Murthy K, Children's Hospital Neonatal Consortium Severe BPD Focus Group.. The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year. J Pediatr. 2018 Aug 29;  

                


                  Nelin TD, Shepherd EG, Nelin LD. In Response to Letter from Altit, Basso, Grandi, and Yang. J Perinatol. 2018 Jun; 38: 768.

                


                  Trittmann JK, Velten M, Heyob KM, Almazroue H, Jin Y, Nelin LD, Rogers LK. Arginase and a-smooth muscle actin induction after hyperoxic exposure in a mouse model of bronchopulmonary dysplasia. Clin Exp Pharmacol Physiol. 2018 Jun; 45: 556-562.

                


                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

                


                  Nelin LD, Shepherd EG. Disappointing results: a call to action. J Thorac Dis. 2018 Feb; 10: 631-633.

                


                  James J, Munson D, DeMauro SB, Langer JC, Dworetz AR, Natarajan G, Bidegain M, Fortney CA, Seabrook R, Vohr BR, Tyson JE, Bell EF, Poindexter BB, Shankaran S, Higgins RD, Das A, Stoll BJ, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr. 2017 Nov; 190: 118-123.e4.

                


                  Nelin LD, Logan JW. The use of inhaled corticosteroids in chronically ventilated preterm infants. Semin Fetal Neonatal Med. 2017 Oct; 22: 296-301.

                


                  Shepherd EG, Nelin LD. Preterm Birth, Bronchopulmonary Dysplasia, and Long-Term Respiratory Disease. Am J Respir Crit Care Med. 2017 Aug 1; 196: 264-265.

View More Publications

Lab(s)

Center for Perinatal Research

The research focus in Leif Nelin’s laboratory is on the elucidation of the functional and mechanistic aspects of cellular uptake of L-arginine by the cationic amino acid transporters (CAT) and the role of CAT activities and expression in regulation of nitric oxide (NO) production in the lung. Furthermore, they are studying the regulation of nitric oxide synthase and arginase induction in models of pulmonary hypertension and lung injury to develop strategies to influence arginine metabolism inside of the cell. Experiments are carried out in cell culture systems and animal models using pharmacological and genetic manipulations with experimental end-points ranging from biochemical assays, protein and mRNA assays, to functional and physiological measurements. The long-term goals of these studies are to develop therapies that increase NO production by facilitating CAT-mediated L-arg uptake in pulmonary hypertensive diseases, and that decrease NO production by inhibiting CAT-mediated L-arg uptake in inflammatory lung diseases. Publications

                  Nelin LD, Shepherd EG. Bones and lungs: insights from mice with fragile bones. J Physiol. 2022 Dec 14;  

                


                  Fortney CA, Baughcum AE, Garcia D, Winning AM, Humphrey L, Cistone N, Moscato EL, Keim MC, Nelin LD, Gerhardt CA. Characteristics of Critically Ill Infants at the End of Life in the Neonatal Intensive Care Unit. J Palliat Med. 2022 Dec 8;  

                


                  Cristea AI, Tracy MC, Bauer SE, Guaman MC, Welty SE, Baker CD, Bhombal S, Collaco JM, Courtney SE, DiGeronimo RJ, Eldredge LC, Gibbs K, Hayden LP, Keszler M, Lai K, McGrath-Morrow SA, Moore PE, Rose R, Sindelar R, Truog WE, Nelin LD, Abman S, BPD Collaborative. Approaches to Interdisciplinary Care for Infants with Severe Bronchopulmonary Dysplasia: A Survey of the Bronchopulmonary Dysplasia Collaborative. Am J Perinatol. 2022 Dec 7;  

                


                  Levin JC, Annesi CA, Williams DN, Abman SH, McGrath-Morrow SA, Nelin LD, Sheils CA, Hayden LP, Bronchopulmonary Dysplasia Collaborative Expert Panel on Discharge Practices.. Discharge Practices for Infants with Bronchopulmonary Dysplasia: A Survey of National Experts. J Pediatr. 2022 Sep 17;  

                


                  Lewis TR, Kielt MJ, Walker VP, Levin JC, Guaman MC, Panitch HB, Nelin LD, Abman SH, Bronchopulmonary Dysplasia Collaborative.. Association of Racial Disparities With In-Hospital Outcomes in Severe Bronchopulmonary Dysplasia. JAMA Pediatr. 2022 Aug 1;  

                


                  McGrath-Morrow SA, Agarwal A, Alexiou S, Austin ED, Fierro JL, Hayden LP, Lai K, Levin JC, Manimtim WM, Moore PE, Rhein LM, Rice JL, Sheils CA, Tracy MC, Bansal M, Baker CD, Cristea AI, Popova AP, Siddaiah R, Villafranco N, Nelin LD, Collaco JM. Daycare Attendance is linked to Increased Risk of Respiratory Morbidities in Preterm Children with Bronchopulmonary Dysplasia. J Pediatr. 2022 Jul 5;  

                


                  Nelin LD, Kielt MJ, Jebbia M, Jadcherla S, Shepherd EG. Bronchodilator responsiveness and dysanapsis in bronchopulmonary dysplasia. ERJ Open Res. 2022 Jul; 8: 

                


                  Miller CJ, Prusakov P, Magers J, Speaks S, Sacic H, Escobar K, Abdel-Rasoul M, Nelin LD. Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit. J Perinatol. 2022 Jun 25;  

                


                  Chen B, Jin Y, Pool CM, Liu Y, Nelin LD. Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation. Physiol Rep. 2022 Jun; 10: e15342.

                


                  Collaco JM, Tracy MC, Sheils CA, Rice JL, Rhein LM, Nelin LD, Moore PE, Manimtim WM, Levin JC, Lai K, Hayden LP, Fierro JL, Austin ED, Alexiou S, Agarwal A, Villafranco N, Siddaiah R, Popova AP, Cristea IA, Baker CD, Bansal M, McGrath-Morrow SA. Insurance coverage and respiratory morbidities in bronchopulmonary dysplasia. Pediatr Pulmonol. 2022 Apr 18;  

                


                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Logan JW, Bapat R, Ryshen G, Bagwell G, Eisner M, Kielt M, Hanawalt M, Payne K, Alt-Coan A, Tatad M, Krendl D, Jebbia M, Reber KM, Halling C, Osman AA, Bonachea EM, Nelin LD, Fathi O. Use of a quality scorecard to enhance quality and safety in community hospital newborn nurseries. J Pediatr. 2022 Mar 28;  

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Lee CD, Nelin L, Foglia EE. Neonatal Resuscitation in 22-Week Pregnancies. N Engl J Med. 2022 Jan 27; 386: 391-393.

                


                  Miller AN, Kielt MJ, El-Ferzli GT, Nelin LD, Shepherd EG. Optimizing ventilator support in severe bronchopulmonary dysplasia in the absence of conclusive evidence. Front Pediatr. 2022; 10: 1022743.

                


                  Sindelar R, Shepherd EG, Ågren J, Panitch HB, Abman SH, Nelin LD, Bronchopulmonary Dysplasia Collaborative.. Established severe BPD: is there a way out? Change of ventilatory paradigms. Pediatr Res. 2021 Dec; 90: 1139-1146.

                


                  Pavlek LR, Mueller C, Jebbia MR, Kielt MJ, Nelin LD, Shepherd EG, Reber KM, Fathi O. Perspectives on developing and sustaining a small baby program. Semin Perinatol. 2021 Nov 10;  151548.

                


                  Trittmann JK, Almazroue H, Nelin LD, Shaffer TA, Celestine CR, Green HW 3rd, Malbrue RA. PATET ratio by Doppler echocardiography: noninvasive detection of pediatric pulmonary arterial hypertension. Pediatr Res. 2021 Nov 18;  

                


                  Kielt MJ, Logan JW, Backes CH, Conroy S, Reber KM, Shepherd EG, Nelin LD. Noninvasive Respiratory Severity Indices Predict Adverse Outcomes in Bronchopulmonary Dysplasia. J Pediatr. 2021 Nov 11;  

                


                  Yallapragada S, Savani RC, Munoz-Blanco S, Lagatta JM, Truog WE, Porta NFM, Nelin LD, Zhang H, Vyas-Read S, DiGeronimo R, Natarajan G, Wymore E, Haberman B, Machry J, Potoka K, Children’s Hospital Neonatal Consortium severe bronchopulmonary dysplasia subgroup., Murthy K. Qualitative indications for tracheostomy and chronic mechanical ventilation in patients with severe bronchopulmonary dysplasia. J Perinatol. 2021 Nov; 41: 2651-2657.

                


                  Kielt MJ, Murphy A, Smathers J, Bates M, Nelin LD, Shepherd EG. In-Hospital Respiratory Viral Infections for Patients with Established BPD in the SARS-CoV-2 Era. Pediatr Pulmonol. 2021 Oct 1;  

                


                  Nelin L, Kinsella JP, Courtney SE, Pallotto EK, Tarau E, Potenziano JL. Use of inhaled nitric oxide in preterm vs term/near-term neonates with pulmonary hypertension: results of the PaTTerN registry study. J Perinatol. 2021 Oct 28;  

                


                  Vyas-Read S, Logan JW, Cuna AC, Machry J, Leeman KT, Rose RS, Mikhael M, Wymore E, Ibrahim JW, DiGeronimo RJ, Yallapragada S, Haberman BE, Padula MA, Porta NF, Murthy K, Nelin LD, Coghill CH, Zaniletti I, Savani RC, Truog W, Engle WA, Lagatta JM. A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children's Hospitals Neonatal Consortium Severe BPD Group. J Perinatol. 2021 Aug 5;  

                


                  Guaman MC, Pishevar N, Abman SH, Keszler M, Truog WE, Panitch H, Nelin LD. Invasive mechanical ventilation at 36 weeks post-menstrual age, adverse outcomes with a comparison of recent definitions of bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1936-1942.

                


                  Kielt MJ, Logan JW, Backes CH, Reber KM, Nelin LD, Shepherd EG. In-hospital outcomes of late referrals for established bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1972-1982.

                


                  Hoffsten A, Markasz L, Ericson K, Nelin LD, Sindelar R. The value of autopsy in preterm infants at a Swedish tertiary neonatal intensive care unit 2002-2018. Sci Rep. 2021 Jul 8; 11: 14156.

                


                  Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  

                


                  Collaco JM, Agarwal A, Austin ED, Hayden LP, Lai K, Levin J, Manimtim WM, Moore PE, Sheils CA, Tracy MC, Alexiou S, Baker CD, Cristea AI, Fierro JL, Rhein LM, Villafranco N, Nelin LD, McGrath-Morrow SA. Characteristics of infants or children presenting to outpatient bronchopulmonary dysplasia clinics in the United States. Pediatr Pulmonol. 2021 Jun; 56: 1617-1625.

                


                  Fathi O, Nelin LD, Shepherd EG, Reber KM. Development of a small baby unit to improve outcomes for the extremely premature infant. J Perinatol. 2021 Mar 12;  

                


                  Stewart WCL, Gnona KM, White P, Kelly B, Klebanoff M, Buhimschi IA, Nelin LD. Prediction of short-term neonatal complications in preterm infants using exome-wide genetic variation and gestational age: a pilot study. Pediatr Res. 2020 Oct; 88: 653-660.

                


                  Pishevar N, Fathi O, Backes CH, Shepherd EG, Nelin LD. Predicting survival in infants born at <27 weeks gestation admitted to an all referral neonatal intensive care unit: a pilot study. J Perinatol. 2020 May; 40: 750-757.

                


                  Bapat R, Nelin L, Shepherd E, Ryshen G, Elgin A, Bartman T. A multidisciplinary quality improvement effort to reduce bronchopulmonary dysplasia incidence. J Perinatol. 2020 Apr; 40: 681-687.

                


                  Bauer SE, Schneider L, Lynch SK, Malleske DT, Shepherd EG, Nelin LD. Factors Associated with Neurodevelopmental Impairment in Bronchopulmonary Dysplasia. J Pediatr. 2020 Jan 8;  

                


                  Vyas-Read S, Wymore EM, Zaniletti I, Murthy K, Padula MA, Truog WE, Engle WA, Savani RC, Yallapragada S, Logan JW, Zhang H, Hysinger EB, Grover TR, Natarajan G, Nelin LD, Porta NFM, Potoka KP, DiGeronimo R, Lagatta JM, Children’s Hospitals Neonatal Consortium Severe BPD Focus Group.. Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia. J Perinatol. 2019 Sep 30;  

                


                  Trittmann JK, Almazroue H, Jin Y, Nelin LD. DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells. Physiol Rep. 2019 Jul; 7: e14150.

                


                  Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.

                


                  Nelin LD, Potenziano JL. Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response. BMC Pediatr. 2019 Jan 12; 19: 17.

                


                  Backes CH, Söderström F, Ågren J, Sindelar R, Bartlett CW, Rivera BK, Mitchell CC, Frey HA, Shepherd EG, Nelin LD, Normann E. Outcomes following a comprehensive versus a selective approach for infants born at 22 weeks of gestation. J Perinatol. 2019 Jan; 39: 39-47.

                


                  Li J, Wang X, Ackerman WE 4th, Batty AJ, Kirk SG, White WM, Wang X, Anastasakis D, Samavati L, Buhimschi I, Nelin LD, Hafner M, Liu Y. Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis. Int J Mol Sci. 2018 Dec 6; 19: 

                


                  Zhang H, Dysart K, Kendrick DE, Li L, Das A, Hintz SR, Vohr BR, Stoll BJ, Higgins RD, Nelin L, Carlton DP, Walsh MC, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Prolonged respiratory support of any type impacts outcomes of extremely low birth weight infants. Pediatr Pulmonol. 2018 Oct; 53: 1447-1455.

                


                  Lagatta JM, Hysinger EB, Zaniletti I, Wymore EM, Vyas-Read S, Yallapragada S, Nelin LD, Truog WE, Padula MA, Porta NFM, Savani RC, Potoka KP, Kawut SM, DiGeronimo R, Natarajan G, Zhang H, Grover TR, Engle WA, Murthy K, Children's Hospital Neonatal Consortium Severe BPD Focus Group.. The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year. J Pediatr. 2018 Aug 29;  

                


                  Nelin TD, Shepherd EG, Nelin LD. In Response to Letter from Altit, Basso, Grandi, and Yang. J Perinatol. 2018 Jun; 38: 768.

                


                  Trittmann JK, Velten M, Heyob KM, Almazroue H, Jin Y, Nelin LD, Rogers LK. Arginase and a-smooth muscle actin induction after hyperoxic exposure in a mouse model of bronchopulmonary dysplasia. Clin Exp Pharmacol Physiol. 2018 Jun; 45: 556-562.

                


                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

                


                  Nelin LD, Shepherd EG. Disappointing results: a call to action. J Thorac Dis. 2018 Feb; 10: 631-633.

                


                  James J, Munson D, DeMauro SB, Langer JC, Dworetz AR, Natarajan G, Bidegain M, Fortney CA, Seabrook R, Vohr BR, Tyson JE, Bell EF, Poindexter BB, Shankaran S, Higgins RD, Das A, Stoll BJ, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr. 2017 Nov; 190: 118-123.e4.

                


                  Nelin LD, Logan JW. The use of inhaled corticosteroids in chronically ventilated preterm infants. Semin Fetal Neonatal Med. 2017 Oct; 22: 296-301.

                


                  Shepherd EG, Nelin LD. Preterm Birth, Bronchopulmonary Dysplasia, and Long-Term Respiratory Disease. Am J Respir Crit Care Med. 2017 Aug 1; 196: 264-265.

View More Publications

Lab(s)

Center for Perinatal Research

The research focus in Leif Nelin’s laboratory is on the elucidation of the functional and mechanistic aspects of cellular uptake of L-arginine by the cationic amino acid transporters (CAT) and the role of CAT activities and expression in regulation of nitric oxide (NO) production in the lung. Furthermore, they are studying the regulation of nitric oxide synthase and arginase induction in models of pulmonary hypertension and lung injury to develop strategies to influence arginine metabolism inside of the cell. Experiments are carried out in cell culture systems and animal models using pharmacological and genetic manipulations with experimental end-points ranging from biochemical assays, protein and mRNA assays, to functional and physiological measurements. The long-term goals of these studies are to develop therapies that increase NO production by facilitating CAT-mediated L-arg uptake in pulmonary hypertensive diseases, and that decrease NO production by inhibiting CAT-mediated L-arg uptake in inflammatory lung diseases.

Lab(s)

Center for Perinatal Research

• Center for Perinatal Research

                  Nelin LD, Shepherd EG. Bones and lungs: insights from mice with fragile bones. J Physiol. 2022 Dec 14;  
  
  
  
                  Fortney CA, Baughcum AE, Garcia D, Winning AM, Humphrey L, Cistone N, Moscato EL, Keim MC, Nelin LD, Gerhardt CA. Characteristics of Critically Ill Infants at the End of Life in the Neonatal Intensive Care Unit. J Palliat Med. 2022 Dec 8;  
  
  
  
                  Cristea AI, Tracy MC, Bauer SE, Guaman MC, Welty SE, Baker CD, Bhombal S, Collaco JM, Courtney SE, DiGeronimo RJ, Eldredge LC, Gibbs K, Hayden LP, Keszler M, Lai K, McGrath-Morrow SA, Moore PE, Rose R, Sindelar R, Truog WE, Nelin LD, Abman S, BPD Collaborative. Approaches to Interdisciplinary Care for Infants with Severe Bronchopulmonary Dysplasia: A Survey of the Bronchopulmonary Dysplasia Collaborative. Am J Perinatol. 2022 Dec 7;  
  
  
  
                  Levin JC, Annesi CA, Williams DN, Abman SH, McGrath-Morrow SA, Nelin LD, Sheils CA, Hayden LP, Bronchopulmonary Dysplasia Collaborative Expert Panel on Discharge Practices.. Discharge Practices for Infants with Bronchopulmonary Dysplasia: A Survey of National Experts. J Pediatr. 2022 Sep 17;  
  
  
  
                  Lewis TR, Kielt MJ, Walker VP, Levin JC, Guaman MC, Panitch HB, Nelin LD, Abman SH, Bronchopulmonary Dysplasia Collaborative.. Association of Racial Disparities With In-Hospital Outcomes in Severe Bronchopulmonary Dysplasia. JAMA Pediatr. 2022 Aug 1;  
  
  
  
                  McGrath-Morrow SA, Agarwal A, Alexiou S, Austin ED, Fierro JL, Hayden LP, Lai K, Levin JC, Manimtim WM, Moore PE, Rhein LM, Rice JL, Sheils CA, Tracy MC, Bansal M, Baker CD, Cristea AI, Popova AP, Siddaiah R, Villafranco N, Nelin LD, Collaco JM. Daycare Attendance is linked to Increased Risk of Respiratory Morbidities in Preterm Children with Bronchopulmonary Dysplasia. J Pediatr. 2022 Jul 5;  
  
  
  
                  Nelin LD, Kielt MJ, Jebbia M, Jadcherla S, Shepherd EG. Bronchodilator responsiveness and dysanapsis in bronchopulmonary dysplasia. ERJ Open Res. 2022 Jul; 8: 
  
  
  
                  Miller CJ, Prusakov P, Magers J, Speaks S, Sacic H, Escobar K, Abdel-Rasoul M, Nelin LD. Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit. J Perinatol. 2022 Jun 25;  
  
  
  
                  Chen B, Jin Y, Pool CM, Liu Y, Nelin LD. Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation. Physiol Rep. 2022 Jun; 10: e15342.
  
  
  
                  Collaco JM, Tracy MC, Sheils CA, Rice JL, Rhein LM, Nelin LD, Moore PE, Manimtim WM, Levin JC, Lai K, Hayden LP, Fierro JL, Austin ED, Alexiou S, Agarwal A, Villafranco N, Siddaiah R, Popova AP, Cristea IA, Baker CD, Bansal M, McGrath-Morrow SA. Insurance coverage and respiratory morbidities in bronchopulmonary dysplasia. Pediatr Pulmonol. 2022 Apr 18;  
  
  
  
                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.
  
  
  
                  Logan JW, Bapat R, Ryshen G, Bagwell G, Eisner M, Kielt M, Hanawalt M, Payne K, Alt-Coan A, Tatad M, Krendl D, Jebbia M, Reber KM, Halling C, Osman AA, Bonachea EM, Nelin LD, Fathi O. Use of a quality scorecard to enhance quality and safety in community hospital newborn nurseries. J Pediatr. 2022 Mar 28;  
  
  
  
                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  
  
  
  
                  Lee CD, Nelin L, Foglia EE. Neonatal Resuscitation in 22-Week Pregnancies. N Engl J Med. 2022 Jan 27; 386: 391-393.
  
  
  
                  Miller AN, Kielt MJ, El-Ferzli GT, Nelin LD, Shepherd EG. Optimizing ventilator support in severe bronchopulmonary dysplasia in the absence of conclusive evidence. Front Pediatr. 2022; 10: 1022743.
  
  
  
                  Sindelar R, Shepherd EG, Ågren J, Panitch HB, Abman SH, Nelin LD, Bronchopulmonary Dysplasia Collaborative.. Established severe BPD: is there a way out? Change of ventilatory paradigms. Pediatr Res. 2021 Dec; 90: 1139-1146.
  
  
  
                  Pavlek LR, Mueller C, Jebbia MR, Kielt MJ, Nelin LD, Shepherd EG, Reber KM, Fathi O. Perspectives on developing and sustaining a small baby program. Semin Perinatol. 2021 Nov 10;  151548.
  
  
  
                  Trittmann JK, Almazroue H, Nelin LD, Shaffer TA, Celestine CR, Green HW 3rd, Malbrue RA. PATET ratio by Doppler echocardiography: noninvasive detection of pediatric pulmonary arterial hypertension. Pediatr Res. 2021 Nov 18;  
  
  
  
                  Kielt MJ, Logan JW, Backes CH, Conroy S, Reber KM, Shepherd EG, Nelin LD. Noninvasive Respiratory Severity Indices Predict Adverse Outcomes in Bronchopulmonary Dysplasia. J Pediatr. 2021 Nov 11;  
  
  
  
                  Yallapragada S, Savani RC, Munoz-Blanco S, Lagatta JM, Truog WE, Porta NFM, Nelin LD, Zhang H, Vyas-Read S, DiGeronimo R, Natarajan G, Wymore E, Haberman B, Machry J, Potoka K, Children’s Hospital Neonatal Consortium severe bronchopulmonary dysplasia subgroup., Murthy K. Qualitative indications for tracheostomy and chronic mechanical ventilation in patients with severe bronchopulmonary dysplasia. J Perinatol. 2021 Nov; 41: 2651-2657.
  
  
  
                  Kielt MJ, Murphy A, Smathers J, Bates M, Nelin LD, Shepherd EG. In-Hospital Respiratory Viral Infections for Patients with Established BPD in the SARS-CoV-2 Era. Pediatr Pulmonol. 2021 Oct 1;  
  
  
  
                  Nelin L, Kinsella JP, Courtney SE, Pallotto EK, Tarau E, Potenziano JL. Use of inhaled nitric oxide in preterm vs term/near-term neonates with pulmonary hypertension: results of the PaTTerN registry study. J Perinatol. 2021 Oct 28;  
  
  
  
                  Vyas-Read S, Logan JW, Cuna AC, Machry J, Leeman KT, Rose RS, Mikhael M, Wymore E, Ibrahim JW, DiGeronimo RJ, Yallapragada S, Haberman BE, Padula MA, Porta NF, Murthy K, Nelin LD, Coghill CH, Zaniletti I, Savani RC, Truog W, Engle WA, Lagatta JM. A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children's Hospitals Neonatal Consortium Severe BPD Group. J Perinatol. 2021 Aug 5;  
  
  
  
                  Guaman MC, Pishevar N, Abman SH, Keszler M, Truog WE, Panitch H, Nelin LD. Invasive mechanical ventilation at 36 weeks post-menstrual age, adverse outcomes with a comparison of recent definitions of bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1936-1942.
  
  
  
                  Kielt MJ, Logan JW, Backes CH, Reber KM, Nelin LD, Shepherd EG. In-hospital outcomes of late referrals for established bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1972-1982.
  
  
  
                  Hoffsten A, Markasz L, Ericson K, Nelin LD, Sindelar R. The value of autopsy in preterm infants at a Swedish tertiary neonatal intensive care unit 2002-2018. Sci Rep. 2021 Jul 8; 11: 14156.
  
  
  
                  Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;  
  
  
  
                  Collaco JM, Agarwal A, Austin ED, Hayden LP, Lai K, Levin J, Manimtim WM, Moore PE, Sheils CA, Tracy MC, Alexiou S, Baker CD, Cristea AI, Fierro JL, Rhein LM, Villafranco N, Nelin LD, McGrath-Morrow SA. Characteristics of infants or children presenting to outpatient bronchopulmonary dysplasia clinics in the United States. Pediatr Pulmonol. 2021 Jun; 56: 1617-1625.
  
  
  
                  Fathi O, Nelin LD, Shepherd EG, Reber KM. Development of a small baby unit to improve outcomes for the extremely premature infant. J Perinatol. 2021 Mar 12;  
  
  
  
                  Stewart WCL, Gnona KM, White P, Kelly B, Klebanoff M, Buhimschi IA, Nelin LD. Prediction of short-term neonatal complications in preterm infants using exome-wide genetic variation and gestational age: a pilot study. Pediatr Res. 2020 Oct; 88: 653-660.
  
  
  
                  Pishevar N, Fathi O, Backes CH, Shepherd EG, Nelin LD. Predicting survival in infants born at <27 weeks gestation admitted to an all referral neonatal intensive care unit: a pilot study. J Perinatol. 2020 May; 40: 750-757.
  
  
  
                  Bapat R, Nelin L, Shepherd E, Ryshen G, Elgin A, Bartman T. A multidisciplinary quality improvement effort to reduce bronchopulmonary dysplasia incidence. J Perinatol. 2020 Apr; 40: 681-687.
  
  
  
                  Bauer SE, Schneider L, Lynch SK, Malleske DT, Shepherd EG, Nelin LD. Factors Associated with Neurodevelopmental Impairment in Bronchopulmonary Dysplasia. J Pediatr. 2020 Jan 8;  
  
  
  
                  Vyas-Read S, Wymore EM, Zaniletti I, Murthy K, Padula MA, Truog WE, Engle WA, Savani RC, Yallapragada S, Logan JW, Zhang H, Hysinger EB, Grover TR, Natarajan G, Nelin LD, Porta NFM, Potoka KP, DiGeronimo R, Lagatta JM, Children’s Hospitals Neonatal Consortium Severe BPD Focus Group.. Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia. J Perinatol. 2019 Sep 30;  
  
  
  
                  Trittmann JK, Almazroue H, Jin Y, Nelin LD. DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells. Physiol Rep. 2019 Jul; 7: e14150.
  
  
  
                  Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.
  
  
  
                  Nelin LD, Potenziano JL. Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response. BMC Pediatr. 2019 Jan 12; 19: 17.
  
  
  
                  Backes CH, Söderström F, Ågren J, Sindelar R, Bartlett CW, Rivera BK, Mitchell CC, Frey HA, Shepherd EG, Nelin LD, Normann E. Outcomes following a comprehensive versus a selective approach for infants born at 22 weeks of gestation. J Perinatol. 2019 Jan; 39: 39-47.
  
  
  
                  Li J, Wang X, Ackerman WE 4th, Batty AJ, Kirk SG, White WM, Wang X, Anastasakis D, Samavati L, Buhimschi I, Nelin LD, Hafner M, Liu Y. Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis. Int J Mol Sci. 2018 Dec 6; 19: 
  
  
  
                  Zhang H, Dysart K, Kendrick DE, Li L, Das A, Hintz SR, Vohr BR, Stoll BJ, Higgins RD, Nelin L, Carlton DP, Walsh MC, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Prolonged respiratory support of any type impacts outcomes of extremely low birth weight infants. Pediatr Pulmonol. 2018 Oct; 53: 1447-1455.
  
  
  
                  Lagatta JM, Hysinger EB, Zaniletti I, Wymore EM, Vyas-Read S, Yallapragada S, Nelin LD, Truog WE, Padula MA, Porta NFM, Savani RC, Potoka KP, Kawut SM, DiGeronimo R, Natarajan G, Zhang H, Grover TR, Engle WA, Murthy K, Children's Hospital Neonatal Consortium Severe BPD Focus Group.. The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year. J Pediatr. 2018 Aug 29;  
  
  
  
                  Nelin TD, Shepherd EG, Nelin LD. In Response to Letter from Altit, Basso, Grandi, and Yang. J Perinatol. 2018 Jun; 38: 768.
  
  
  
                  Trittmann JK, Velten M, Heyob KM, Almazroue H, Jin Y, Nelin LD, Rogers LK. Arginase and a-smooth muscle actin induction after hyperoxic exposure in a mouse model of bronchopulmonary dysplasia. Clin Exp Pharmacol Physiol. 2018 Jun; 45: 556-562.
  
  
  
                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.
  
  
  
                  Nelin LD, Shepherd EG. Disappointing results: a call to action. J Thorac Dis. 2018 Feb; 10: 631-633.
  
  
  
                  James J, Munson D, DeMauro SB, Langer JC, Dworetz AR, Natarajan G, Bidegain M, Fortney CA, Seabrook R, Vohr BR, Tyson JE, Bell EF, Poindexter BB, Shankaran S, Higgins RD, Das A, Stoll BJ, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr. 2017 Nov; 190: 118-123.e4.
  
  
  
                  Nelin LD, Logan JW. The use of inhaled corticosteroids in chronically ventilated preterm infants. Semin Fetal Neonatal Med. 2017 Oct; 22: 296-301.
  
  
  
                  Shepherd EG, Nelin LD. Preterm Birth, Bronchopulmonary Dysplasia, and Long-Term Respiratory Disease. Am J Respir Crit Care Med. 2017 Aug 1; 196: 264-265.
  
  

View More Publications

• Nelin LD, Shepherd EG. Bones and lungs: insights from mice with fragile bones. J Physiol. 2022 Dec 14;
• Fortney CA, Baughcum AE, Garcia D, Winning AM, Humphrey L, Cistone N, Moscato EL, Keim MC, Nelin LD, Gerhardt CA. Characteristics of Critically Ill Infants at the End of Life in the Neonatal Intensive Care Unit. J Palliat Med. 2022 Dec 8;
• Cristea AI, Tracy MC, Bauer SE, Guaman MC, Welty SE, Baker CD, Bhombal S, Collaco JM, Courtney SE, DiGeronimo RJ, Eldredge LC, Gibbs K, Hayden LP, Keszler M, Lai K, McGrath-Morrow SA, Moore PE, Rose R, Sindelar R, Truog WE, Nelin LD, Abman S, BPD Collaborative. Approaches to Interdisciplinary Care for Infants with Severe Bronchopulmonary Dysplasia: A Survey of the Bronchopulmonary Dysplasia Collaborative. Am J Perinatol. 2022 Dec 7;
• Levin JC, Annesi CA, Williams DN, Abman SH, McGrath-Morrow SA, Nelin LD, Sheils CA, Hayden LP, Bronchopulmonary Dysplasia Collaborative Expert Panel on Discharge Practices.. Discharge Practices for Infants with Bronchopulmonary Dysplasia: A Survey of National Experts. J Pediatr. 2022 Sep 17;
• Lewis TR, Kielt MJ, Walker VP, Levin JC, Guaman MC, Panitch HB, Nelin LD, Abman SH, Bronchopulmonary Dysplasia Collaborative.. Association of Racial Disparities With In-Hospital Outcomes in Severe Bronchopulmonary Dysplasia. JAMA Pediatr. 2022 Aug 1;
• McGrath-Morrow SA, Agarwal A, Alexiou S, Austin ED, Fierro JL, Hayden LP, Lai K, Levin JC, Manimtim WM, Moore PE, Rhein LM, Rice JL, Sheils CA, Tracy MC, Bansal M, Baker CD, Cristea AI, Popova AP, Siddaiah R, Villafranco N, Nelin LD, Collaco JM. Daycare Attendance is linked to Increased Risk of Respiratory Morbidities in Preterm Children with Bronchopulmonary Dysplasia. J Pediatr. 2022 Jul 5;
• Nelin LD, Kielt MJ, Jebbia M, Jadcherla S, Shepherd EG. Bronchodilator responsiveness and dysanapsis in bronchopulmonary dysplasia. ERJ Open Res. 2022 Jul; 8:
• Miller CJ, Prusakov P, Magers J, Speaks S, Sacic H, Escobar K, Abdel-Rasoul M, Nelin LD. Effects of prophylactic indomethacin on intraventricular hemorrhage and adverse outcomes in neonatal intensive care unit. J Perinatol. 2022 Jun 25;
• Chen B, Jin Y, Pool CM, Liu Y, Nelin LD. Hypoxic pulmonary endothelial cells release epidermal growth factor leading to vascular smooth muscle cell arginase-2 expression and proliferation. Physiol Rep. 2022 Jun; 10: e15342.
• Collaco JM, Tracy MC, Sheils CA, Rice JL, Rhein LM, Nelin LD, Moore PE, Manimtim WM, Levin JC, Lai K, Hayden LP, Fierro JL, Austin ED, Alexiou S, Agarwal A, Villafranco N, Siddaiah R, Popova AP, Cristea IA, Baker CD, Bansal M, McGrath-Morrow SA. Insurance coverage and respiratory morbidities in bronchopulmonary dysplasia. Pediatr Pulmonol. 2022 Apr 18;
• Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13; 101938.
• Logan JW, Bapat R, Ryshen G, Bagwell G, Eisner M, Kielt M, Hanawalt M, Payne K, Alt-Coan A, Tatad M, Krendl D, Jebbia M, Reber KM, Halling C, Osman AA, Bonachea EM, Nelin LD, Fathi O. Use of a quality scorecard to enhance quality and safety in community hospital newborn nurseries. J Pediatr. 2022 Mar 28;
• Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;
• Lee CD, Nelin L, Foglia EE. Neonatal Resuscitation in 22-Week Pregnancies. N Engl J Med. 2022 Jan 27; 386: 391-393.
• Miller AN, Kielt MJ, El-Ferzli GT, Nelin LD, Shepherd EG. Optimizing ventilator support in severe bronchopulmonary dysplasia in the absence of conclusive evidence. Front Pediatr. 2022; 10: 1022743.
• Sindelar R, Shepherd EG, Ågren J, Panitch HB, Abman SH, Nelin LD, Bronchopulmonary Dysplasia Collaborative.. Established severe BPD: is there a way out? Change of ventilatory paradigms. Pediatr Res. 2021 Dec; 90: 1139-1146.
• Pavlek LR, Mueller C, Jebbia MR, Kielt MJ, Nelin LD, Shepherd EG, Reber KM, Fathi O. Perspectives on developing and sustaining a small baby program. Semin Perinatol. 2021 Nov 10; 151548.
• Trittmann JK, Almazroue H, Nelin LD, Shaffer TA, Celestine CR, Green HW 3rd, Malbrue RA. PATET ratio by Doppler echocardiography: noninvasive detection of pediatric pulmonary arterial hypertension. Pediatr Res. 2021 Nov 18;
• Kielt MJ, Logan JW, Backes CH, Conroy S, Reber KM, Shepherd EG, Nelin LD. Noninvasive Respiratory Severity Indices Predict Adverse Outcomes in Bronchopulmonary Dysplasia. J Pediatr. 2021 Nov 11;
• Yallapragada S, Savani RC, Munoz-Blanco S, Lagatta JM, Truog WE, Porta NFM, Nelin LD, Zhang H, Vyas-Read S, DiGeronimo R, Natarajan G, Wymore E, Haberman B, Machry J, Potoka K, Children’s Hospital Neonatal Consortium severe bronchopulmonary dysplasia subgroup., Murthy K. Qualitative indications for tracheostomy and chronic mechanical ventilation in patients with severe bronchopulmonary dysplasia. J Perinatol. 2021 Nov; 41: 2651-2657.
• Kielt MJ, Murphy A, Smathers J, Bates M, Nelin LD, Shepherd EG. In-Hospital Respiratory Viral Infections for Patients with Established BPD in the SARS-CoV-2 Era. Pediatr Pulmonol. 2021 Oct 1;
• Nelin L, Kinsella JP, Courtney SE, Pallotto EK, Tarau E, Potenziano JL. Use of inhaled nitric oxide in preterm vs term/near-term neonates with pulmonary hypertension: results of the PaTTerN registry study. J Perinatol. 2021 Oct 28;
• Vyas-Read S, Logan JW, Cuna AC, Machry J, Leeman KT, Rose RS, Mikhael M, Wymore E, Ibrahim JW, DiGeronimo RJ, Yallapragada S, Haberman BE, Padula MA, Porta NF, Murthy K, Nelin LD, Coghill CH, Zaniletti I, Savani RC, Truog W, Engle WA, Lagatta JM. A comparison of newer classifications of bronchopulmonary dysplasia: findings from the Children’s Hospitals Neonatal Consortium Severe BPD Group. J Perinatol. 2021 Aug 5;
• Guaman MC, Pishevar N, Abman SH, Keszler M, Truog WE, Panitch H, Nelin LD. Invasive mechanical ventilation at 36 weeks post-menstrual age, adverse outcomes with a comparison of recent definitions of bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1936-1942.
• Kielt MJ, Logan JW, Backes CH, Reber KM, Nelin LD, Shepherd EG. In-hospital outcomes of late referrals for established bronchopulmonary dysplasia. J Perinatol. 2021 Aug; 41: 1972-1982.
• Hoffsten A, Markasz L, Ericson K, Nelin LD, Sindelar R. The value of autopsy in preterm infants at a Swedish tertiary neonatal intensive care unit 2002-2018. Sci Rep. 2021 Jul 8; 11: 14156.
• Trittmann JK, Jin Y, Liu Y, Nelin LD. Differential effects of the Src family tyrosine kinases yes and fyn on lipopolysaccharide-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2021 Jun 9;
• Collaco JM, Agarwal A, Austin ED, Hayden LP, Lai K, Levin J, Manimtim WM, Moore PE, Sheils CA, Tracy MC, Alexiou S, Baker CD, Cristea AI, Fierro JL, Rhein LM, Villafranco N, Nelin LD, McGrath-Morrow SA. Characteristics of infants or children presenting to outpatient bronchopulmonary dysplasia clinics in the United States. Pediatr Pulmonol. 2021 Jun; 56: 1617-1625.
• Fathi O, Nelin LD, Shepherd EG, Reber KM. Development of a small baby unit to improve outcomes for the extremely premature infant. J Perinatol. 2021 Mar 12;
• Stewart WCL, Gnona KM, White P, Kelly B, Klebanoff M, Buhimschi IA, Nelin LD. Prediction of short-term neonatal complications in preterm infants using exome-wide genetic variation and gestational age: a pilot study. Pediatr Res. 2020 Oct; 88: 653-660.
• Pishevar N, Fathi O, Backes CH, Shepherd EG, Nelin LD. Predicting survival in infants born at <27 weeks gestation admitted to an all referral neonatal intensive care unit: a pilot study. J Perinatol. 2020 May; 40: 750-757.
• Bapat R, Nelin L, Shepherd E, Ryshen G, Elgin A, Bartman T. A multidisciplinary quality improvement effort to reduce bronchopulmonary dysplasia incidence. J Perinatol. 2020 Apr; 40: 681-687.
• Bauer SE, Schneider L, Lynch SK, Malleske DT, Shepherd EG, Nelin LD. Factors Associated with Neurodevelopmental Impairment in Bronchopulmonary Dysplasia. J Pediatr. 2020 Jan 8;
• Vyas-Read S, Wymore EM, Zaniletti I, Murthy K, Padula MA, Truog WE, Engle WA, Savani RC, Yallapragada S, Logan JW, Zhang H, Hysinger EB, Grover TR, Natarajan G, Nelin LD, Porta NFM, Potoka KP, DiGeronimo R, Lagatta JM, Children’s Hospitals Neonatal Consortium Severe BPD Focus Group.. Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia. J Perinatol. 2019 Sep 30;
• Trittmann JK, Almazroue H, Jin Y, Nelin LD. DDAH1 regulates apoptosis and angiogenesis in human fetal pulmonary microvascular endothelial cells. Physiol Rep. 2019 Jul; 7: e14150.
• Jin Y, Liu Y, Nelin LD. Deficiency of cationic amino acid transporter-2 protects mice from hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2019 Apr 1; 316: L598-L607.
• Nelin LD, Potenziano JL. Inhaled nitric oxide for neonates with persistent pulmonary hypertension of the newborn in the CINRGI study: time to treatment response. BMC Pediatr. 2019 Jan 12; 19: 17.
• Backes CH, Söderström F, Ågren J, Sindelar R, Bartlett CW, Rivera BK, Mitchell CC, Frey HA, Shepherd EG, Nelin LD, Normann E. Outcomes following a comprehensive versus a selective approach for infants born at 22 weeks of gestation. J Perinatol. 2019 Jan; 39: 39-47.
• Li J, Wang X, Ackerman WE 4th, Batty AJ, Kirk SG, White WM, Wang X, Anastasakis D, Samavati L, Buhimschi I, Nelin LD, Hafner M, Liu Y. Dysregulation of Lipid Metabolism in Mkp-1 Deficient Mice during Gram-Negative Sepsis. Int J Mol Sci. 2018 Dec 6; 19:
• Zhang H, Dysart K, Kendrick DE, Li L, Das A, Hintz SR, Vohr BR, Stoll BJ, Higgins RD, Nelin L, Carlton DP, Walsh MC, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Prolonged respiratory support of any type impacts outcomes of extremely low birth weight infants. Pediatr Pulmonol. 2018 Oct; 53: 1447-1455.
• Lagatta JM, Hysinger EB, Zaniletti I, Wymore EM, Vyas-Read S, Yallapragada S, Nelin LD, Truog WE, Padula MA, Porta NFM, Savani RC, Potoka KP, Kawut SM, DiGeronimo R, Natarajan G, Zhang H, Grover TR, Engle WA, Murthy K, Children’s Hospital Neonatal Consortium Severe BPD Focus Group.. The Impact of Pulmonary Hypertension in Preterm Infants with Severe Bronchopulmonary Dysplasia through 1 Year. J Pediatr. 2018 Aug 29;
• Nelin TD, Shepherd EG, Nelin LD. In Response to Letter from Altit, Basso, Grandi, and Yang. J Perinatol. 2018 Jun; 38: 768.
• Trittmann JK, Velten M, Heyob KM, Almazroue H, Jin Y, Nelin LD, Rogers LK. Arginase and a-smooth muscle actin induction after hyperoxic exposure in a mouse model of bronchopulmonary dysplasia. Clin Exp Pharmacol Physiol. 2018 Jun; 45: 556-562.
• Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.
• Nelin LD, Shepherd EG. Disappointing results: a call to action. J Thorac Dis. 2018 Feb; 10: 631-633.
• James J, Munson D, DeMauro SB, Langer JC, Dworetz AR, Natarajan G, Bidegain M, Fortney CA, Seabrook R, Vohr BR, Tyson JE, Bell EF, Poindexter BB, Shankaran S, Higgins RD, Das A, Stoll BJ, Kirpalani H, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.. Outcomes of Preterm Infants following Discussions about Withdrawal or Withholding of Life Support. J Pediatr. 2017 Nov; 190: 118-123.e4.
• Nelin LD, Logan JW. The use of inhaled corticosteroids in chronically ventilated preterm infants. Semin Fetal Neonatal Med. 2017 Oct; 22: 296-301.
• Shepherd EG, Nelin LD. Preterm Birth, Bronchopulmonary Dysplasia, and Long-Term Respiratory Disease. Am J Respir Crit Care Med. 2017 Aug 1; 196: 264-265.

Education

Date of Appointment at Nationwide Children’s Hospital: 05/23/2003

Board Certifications

Neonatal-Perinatal Medicine

Fellowship

Baylor College of Medicine

Date Completed: 06/30/1988

Residency

Uppsala University

Date Completed: 01/01/1986

Residency

Baylor College of Medicine

Date Completed: 06/30/1985

Internship

Baylor College of Medicine

Date Completed: 06/30/1983

Medical School

University of South Florida

Date Completed: 06/12/1982

Education

Date of Appointment at Nationwide Children’s Hospital: 05/23/2003

Board Certifications

Neonatal-Perinatal Medicine

Fellowship

Baylor College of Medicine

Date Completed: 06/30/1988

Residency

Uppsala University

Date Completed: 01/01/1986

Residency

Baylor College of Medicine

Date Completed: 06/30/1985

Internship

Baylor College of Medicine

Date Completed: 06/30/1983

Medical School

University of South Florida

Date Completed: 06/12/1982

Education

Date of Appointment at Nationwide Children’s Hospital: 05/23/2003

Board Certifications

Neonatal-Perinatal Medicine

Fellowship

Baylor College of Medicine

Date Completed: 06/30/1988

Residency

Uppsala University

Date Completed: 01/01/1986

Residency

Baylor College of Medicine

Date Completed: 06/30/1985

Internship

Baylor College of Medicine

Date Completed: 06/30/1983

Medical School

University of South Florida

Date Completed: 06/12/1982

Date of Appointment at Nationwide Children’s Hospital: 05/23/2003

Board Certifications

Neonatal-Perinatal Medicine

Fellowship

Baylor College of Medicine

Date Completed: 06/30/1988

Residency

Uppsala University

Date Completed: 01/01/1986

Residency

Baylor College of Medicine

Date Completed: 06/30/1985

Internship

Baylor College of Medicine

Date Completed: 06/30/1983

Medical School

University of South Florida

Date Completed: 06/12/1982

Date of Appointment at Nationwide Children’s Hospital: 05/23/2003

Board Certifications

Neonatal-Perinatal Medicine

Fellowship

Baylor College of Medicine

Date Completed: 06/30/1988

Residency

Uppsala University

Date Completed: 01/01/1986

Residency

Baylor College of Medicine

Date Completed: 06/30/1985

Internship

Baylor College of Medicine

Date Completed: 06/30/1983

Medical School

University of South Florida

Date Completed: 06/12/1982

• Neonatal-Perinatal Medicine

Professional Experience

2010 - Present Division of Neonatology, The Ohio State University, Interim Chief2007 - Present Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Director2002 - Present Department of Pediatrics, Ohio State University, Associate Professor2006 - 2007 Center for Perinatal Research, Nationwide Children’s Research Institute, Interim Director2002 - 2006 Center for Developmental Pharmacology and Toxicology, Columbus Children’s Research Institute, Investigator1998 - 2002 Department of Pediatrics, University of New Mexico, Associate Professor1994 - 1998 Department of Pediatrics, Medical College of Wisconsin, Associate Professor1994 - 1998 Biomedical engineering Department, Marquette University, Adjunct Associate Professor1989 - 1994 Department of Pediatrics, Medical College of Wisconsin, Assistant Professor

Professional Experience

2010 - Present Division of Neonatology, The Ohio State University, Interim Chief2007 - Present Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Director2002 - Present Department of Pediatrics, Ohio State University, Associate Professor2006 - 2007 Center for Perinatal Research, Nationwide Children’s Research Institute, Interim Director2002 - 2006 Center for Developmental Pharmacology and Toxicology, Columbus Children’s Research Institute, Investigator1998 - 2002 Department of Pediatrics, University of New Mexico, Associate Professor1994 - 1998 Department of Pediatrics, Medical College of Wisconsin, Associate Professor1994 - 1998 Biomedical engineering Department, Marquette University, Adjunct Associate Professor1989 - 1994 Department of Pediatrics, Medical College of Wisconsin, Assistant Professor

Professional Experience

2010 - Present Division of Neonatology, The Ohio State University, Interim Chief2007 - Present Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Director2002 - Present Department of Pediatrics, Ohio State University, Associate Professor2006 - 2007 Center for Perinatal Research, Nationwide Children’s Research Institute, Interim Director2002 - 2006 Center for Developmental Pharmacology and Toxicology, Columbus Children’s Research Institute, Investigator1998 - 2002 Department of Pediatrics, University of New Mexico, Associate Professor1994 - 1998 Department of Pediatrics, Medical College of Wisconsin, Associate Professor1994 - 1998 Biomedical engineering Department, Marquette University, Adjunct Associate Professor1989 - 1994 Department of Pediatrics, Medical College of Wisconsin, Assistant Professor

2010 - Present Division of Neonatology, The Ohio State University, Interim Chief2007 - Present Center for Perinatal Research, The Research Institute at Nationwide Children’s Hospital, Director2002 - Present Department of Pediatrics, Ohio State University, Associate Professor2006 - 2007 Center for Perinatal Research, Nationwide Children’s Research Institute, Interim Director2002 - 2006 Center for Developmental Pharmacology and Toxicology, Columbus Children’s Research Institute, Investigator1998 - 2002 Department of Pediatrics, University of New Mexico, Associate Professor1994 - 1998 Department of Pediatrics, Medical College of Wisconsin, Associate Professor1994 - 1998 Biomedical engineering Department, Marquette University, Adjunct Associate Professor1989 - 1994 Department of Pediatrics, Medical College of Wisconsin, Assistant Professor

2010 - Present Division of Neonatology, The Ohio State University, Interim Chief

Contact Information

Pediatrics

Call us at: (614) 722-4559

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pediatrics

Call us at: (614) 722-4559

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pediatrics

Call us at: (614) 722-4559

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Pediatrics

Call us at: (614) 722-4559

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-4559

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-4559

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

• Call us at:
• (614) 722-4559
• Fax us at:
• (614) 722-4541
• Neonatology700 Children’s DrColumbus, OH 43205 (map)