Juhi Bagaitkar

Contact Information

Email Juhi Bagaitkar, PhD

Center for Microbial Pathogenesis700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Juhi Bagaitkar

Research

Interests

Host Pathogen Interactions Neutrophil Disorders and NADPH Oxidase Oral Inflammation

Lab(s)

Center for Microbial Pathogenesis

The Bagaitkar laboratory studies the complex interactions between innate immune cells, epithelial cells, and microbial colonizers at mucosal barrier surfaces. Reciprocal and heterogenous interactions between these three entities determine host susceptibility to chronic inflammation, cancers and mucosal infections with bacterial and viral pathogens. The oral mucosal barrier is immunologically complex and serves as a gateway to the respiratory and gastrointestinal mucosal surfaces. It is heavily colonized by a rich and diverse oral microbiome and constantly subject to foreign antigens, allergens and invasion by bacterial and viral pathogens. Thus, the maintenance of immune homeostasis at the oral mucosa is a complex, incompletely understood process. The research projects in the lab are centered around three main areas of focus. 1) Manipulation of host innate immune responses by bacterial and viral pathogens at the oral barrier 2) Regulation of immune effector responses of neutrophil and macrophage 3) Immunodeficiencies that impair neutrophil functional responses and enhance susceptibility to chronic inflammation and autoimmunity (Chronic Granulomatous Disease).

View My Publications

Publications

                  Song Z, Bhattacharya S, Huang G, Greenberg ZJ, Yang W, Bagaitkar J, Schuettpelz L, Dinauer MC. NADPH oxidase 2 limits amplification of IL-1ß-G-CSF axis and an immature neutrophil subset in murine lung inflammation. Blood Adv. 2022 Sep 14;  

                


                  Bhattacharya S, Idol R, Yang W, Rojas Marquez JD, Li Y, Huang G, Beatty W, Atkinson JJ, Brumell J, Bagaitkar J, Magee JA, Dinauer MC. Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice. Blood. 2022 Mar 23;  

                


                  Bagaitkar J. Environment tames CGD macrophages. Blood. 2022 Mar 17; 139: 1611-1612.

                


                  Rodriguez-Hernandez CJ, Sokoloski KJ, Stocke KS, Dukka H, Jin S, Metzler MA, Zaitsev K, Shpak B, Shen D, Miller DP, Artyomov MN, Lamont RJ, Bagaitkar J. Microbiome-mediated incapacitation of interferon lambda production in the oral mucosa. Proc Natl Acad Sci U S A. 2021 Dec 21; 118: 

                


                  Fitzsimonds ZR, Liu C, Stocke KS, Yakoumatos L, Shumway B, Miller DP, Artyomov MN, Bagaitkar J, Lamont RJ. Regulation of olfactomedin 4 by Porphyromonas gingivalis in a community context. ISME J. 2021 Sep; 15: 2627-2642.

                


                  Shchukina I, Bagaitkar J, Shpynov O, Loginicheva E, Porter S, Mogilenko DA, Wolin E, Collins P, Demidov G, Artomov M, Zaitsev K, Sidorov S, Camell C, Bambouskova M, Arthur L, Swain A, Panteleeva A, Dievskii A, Kurbatsky E, Tsurinov P, Chernyatchik R, Dixit VD, Jovanovic M, Stewart SA, Daly MJ, Dmitriev S, Oltz EM, Artyomov MN. Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome. Nat Aging. 2021 Jan; 1: 124-141.

                


                  Zeng MY, Miralda I, Armstrong CL, Uriarte SM, Bagaitkar J. The roles of NADPH oxidase in modulating neutrophil effector responses. Mol Oral Microbiol. 2019 Apr; 34: 27-38.

                


                  Bagaitkar J, Huang J, Zeng MY, Pech NK, Monlish DA, Perez-Zapata LJ, Miralda I, Schuettpelz LG, Dinauer MC. NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood. 2018 May 24; 131: 2367-2378.

View More Publications

Biography

Juhi Bagaitkar, PhD, is a Principal Investigator in the Center for Microbial Pathogenesis and an Associate Professor in the Department of Pediatrics at The Ohio State University. She is an NIH funded investigator whose research focuses on understanding host-pathogen interactions, and innate immune pathways that regulate tolerogenic immunity at the oral mucosal barrier.

Academic and Clinical Areas

Center for Microbial Pathogenesis

Principal Investigator

Primary Department

Center for Microbial Pathogenesis

Awards, Honors & Organizations

Associate Councilor, Society for Leukocyte Biology, 2019 Early Career Faculty Award, Society for Leukocyte Biology, Annual meeting, 2018 Adel A. Younis Award for Excellence in Hematology, Washington University School of Medicine, St. Louis, 2014 Guy Stevenson Award for Excellence in Graduate Studies, University of Louisville, 2010 Presidential Award, Society for Leukocyte Biology, Annual Meeting, 2010

Education

Post Doctoral

Washington University in St. Louis

Date Completed: 11/30/2016

Graduate School

UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE

Date Completed: 12/10/2010

Professional Experience

2016 - 2021 University of Louisville, Assistant Professor

Contact Information

Center for Microbial Pathogenesis

Email Juhi Bagaitkar

                    700 Children’s DriveColumbus, OH 43205 (map)

Contact Information

Email Juhi Bagaitkar, PhD

Center for Microbial Pathogenesis700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Juhi Bagaitkar

Research

Interests

Host Pathogen Interactions Neutrophil Disorders and NADPH Oxidase Oral Inflammation

Lab(s)

Center for Microbial Pathogenesis

The Bagaitkar laboratory studies the complex interactions between innate immune cells, epithelial cells, and microbial colonizers at mucosal barrier surfaces. Reciprocal and heterogenous interactions between these three entities determine host susceptibility to chronic inflammation, cancers and mucosal infections with bacterial and viral pathogens. The oral mucosal barrier is immunologically complex and serves as a gateway to the respiratory and gastrointestinal mucosal surfaces. It is heavily colonized by a rich and diverse oral microbiome and constantly subject to foreign antigens, allergens and invasion by bacterial and viral pathogens. Thus, the maintenance of immune homeostasis at the oral mucosa is a complex, incompletely understood process. The research projects in the lab are centered around three main areas of focus. 1) Manipulation of host innate immune responses by bacterial and viral pathogens at the oral barrier 2) Regulation of immune effector responses of neutrophil and macrophage 3) Immunodeficiencies that impair neutrophil functional responses and enhance susceptibility to chronic inflammation and autoimmunity (Chronic Granulomatous Disease).

View My Publications

Publications

                  Song Z, Bhattacharya S, Huang G, Greenberg ZJ, Yang W, Bagaitkar J, Schuettpelz L, Dinauer MC. NADPH oxidase 2 limits amplification of IL-1ß-G-CSF axis and an immature neutrophil subset in murine lung inflammation. Blood Adv. 2022 Sep 14;  

                


                  Bhattacharya S, Idol R, Yang W, Rojas Marquez JD, Li Y, Huang G, Beatty W, Atkinson JJ, Brumell J, Bagaitkar J, Magee JA, Dinauer MC. Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice. Blood. 2022 Mar 23;  

                


                  Bagaitkar J. Environment tames CGD macrophages. Blood. 2022 Mar 17; 139: 1611-1612.

                


                  Rodriguez-Hernandez CJ, Sokoloski KJ, Stocke KS, Dukka H, Jin S, Metzler MA, Zaitsev K, Shpak B, Shen D, Miller DP, Artyomov MN, Lamont RJ, Bagaitkar J. Microbiome-mediated incapacitation of interferon lambda production in the oral mucosa. Proc Natl Acad Sci U S A. 2021 Dec 21; 118: 

                


                  Fitzsimonds ZR, Liu C, Stocke KS, Yakoumatos L, Shumway B, Miller DP, Artyomov MN, Bagaitkar J, Lamont RJ. Regulation of olfactomedin 4 by Porphyromonas gingivalis in a community context. ISME J. 2021 Sep; 15: 2627-2642.

                


                  Shchukina I, Bagaitkar J, Shpynov O, Loginicheva E, Porter S, Mogilenko DA, Wolin E, Collins P, Demidov G, Artomov M, Zaitsev K, Sidorov S, Camell C, Bambouskova M, Arthur L, Swain A, Panteleeva A, Dievskii A, Kurbatsky E, Tsurinov P, Chernyatchik R, Dixit VD, Jovanovic M, Stewart SA, Daly MJ, Dmitriev S, Oltz EM, Artyomov MN. Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome. Nat Aging. 2021 Jan; 1: 124-141.

                


                  Zeng MY, Miralda I, Armstrong CL, Uriarte SM, Bagaitkar J. The roles of NADPH oxidase in modulating neutrophil effector responses. Mol Oral Microbiol. 2019 Apr; 34: 27-38.

                


                  Bagaitkar J, Huang J, Zeng MY, Pech NK, Monlish DA, Perez-Zapata LJ, Miralda I, Schuettpelz LG, Dinauer MC. NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood. 2018 May 24; 131: 2367-2378.

View More Publications

Biography

Juhi Bagaitkar, PhD, is a Principal Investigator in the Center for Microbial Pathogenesis and an Associate Professor in the Department of Pediatrics at The Ohio State University. She is an NIH funded investigator whose research focuses on understanding host-pathogen interactions, and innate immune pathways that regulate tolerogenic immunity at the oral mucosal barrier.

Academic and Clinical Areas

Center for Microbial Pathogenesis

Principal Investigator

Primary Department

Center for Microbial Pathogenesis

Awards, Honors & Organizations

Associate Councilor, Society for Leukocyte Biology, 2019 Early Career Faculty Award, Society for Leukocyte Biology, Annual meeting, 2018 Adel A. Younis Award for Excellence in Hematology, Washington University School of Medicine, St. Louis, 2014 Guy Stevenson Award for Excellence in Graduate Studies, University of Louisville, 2010 Presidential Award, Society for Leukocyte Biology, Annual Meeting, 2010

Education

Post Doctoral

Washington University in St. Louis

Date Completed: 11/30/2016

Graduate School

UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE

Date Completed: 12/10/2010

Professional Experience

2016 - 2021 University of Louisville, Assistant Professor

Contact Information

Center for Microbial Pathogenesis

Email Juhi Bagaitkar

                    700 Children’s DriveColumbus, OH 43205 (map)

Contact Information

Email Juhi Bagaitkar, PhD

Center for Microbial Pathogenesis700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Juhi Bagaitkar

Contact Information

• Email Juhi Bagaitkar, PhD
• Center for Microbial Pathogenesis700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Juhi Bagaitkar

Research

Interests

Host Pathogen Interactions Neutrophil Disorders and NADPH Oxidase Oral Inflammation

Lab(s)

Center for Microbial Pathogenesis

The Bagaitkar laboratory studies the complex interactions between innate immune cells, epithelial cells, and microbial colonizers at mucosal barrier surfaces. Reciprocal and heterogenous interactions between these three entities determine host susceptibility to chronic inflammation, cancers and mucosal infections with bacterial and viral pathogens. The oral mucosal barrier is immunologically complex and serves as a gateway to the respiratory and gastrointestinal mucosal surfaces. It is heavily colonized by a rich and diverse oral microbiome and constantly subject to foreign antigens, allergens and invasion by bacterial and viral pathogens. Thus, the maintenance of immune homeostasis at the oral mucosa is a complex, incompletely understood process. The research projects in the lab are centered around three main areas of focus. 1) Manipulation of host innate immune responses by bacterial and viral pathogens at the oral barrier 2) Regulation of immune effector responses of neutrophil and macrophage 3) Immunodeficiencies that impair neutrophil functional responses and enhance susceptibility to chronic inflammation and autoimmunity (Chronic Granulomatous Disease).

View My Publications

Publications

                  Song Z, Bhattacharya S, Huang G, Greenberg ZJ, Yang W, Bagaitkar J, Schuettpelz L, Dinauer MC. NADPH oxidase 2 limits amplification of IL-1ß-G-CSF axis and an immature neutrophil subset in murine lung inflammation. Blood Adv. 2022 Sep 14;  

                


                  Bhattacharya S, Idol R, Yang W, Rojas Marquez JD, Li Y, Huang G, Beatty W, Atkinson JJ, Brumell J, Bagaitkar J, Magee JA, Dinauer MC. Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice. Blood. 2022 Mar 23;  

                


                  Bagaitkar J. Environment tames CGD macrophages. Blood. 2022 Mar 17; 139: 1611-1612.

                


                  Rodriguez-Hernandez CJ, Sokoloski KJ, Stocke KS, Dukka H, Jin S, Metzler MA, Zaitsev K, Shpak B, Shen D, Miller DP, Artyomov MN, Lamont RJ, Bagaitkar J. Microbiome-mediated incapacitation of interferon lambda production in the oral mucosa. Proc Natl Acad Sci U S A. 2021 Dec 21; 118: 

                


                  Fitzsimonds ZR, Liu C, Stocke KS, Yakoumatos L, Shumway B, Miller DP, Artyomov MN, Bagaitkar J, Lamont RJ. Regulation of olfactomedin 4 by Porphyromonas gingivalis in a community context. ISME J. 2021 Sep; 15: 2627-2642.

                


                  Shchukina I, Bagaitkar J, Shpynov O, Loginicheva E, Porter S, Mogilenko DA, Wolin E, Collins P, Demidov G, Artomov M, Zaitsev K, Sidorov S, Camell C, Bambouskova M, Arthur L, Swain A, Panteleeva A, Dievskii A, Kurbatsky E, Tsurinov P, Chernyatchik R, Dixit VD, Jovanovic M, Stewart SA, Daly MJ, Dmitriev S, Oltz EM, Artyomov MN. Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome. Nat Aging. 2021 Jan; 1: 124-141.

                


                  Zeng MY, Miralda I, Armstrong CL, Uriarte SM, Bagaitkar J. The roles of NADPH oxidase in modulating neutrophil effector responses. Mol Oral Microbiol. 2019 Apr; 34: 27-38.

                


                  Bagaitkar J, Huang J, Zeng MY, Pech NK, Monlish DA, Perez-Zapata LJ, Miralda I, Schuettpelz LG, Dinauer MC. NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood. 2018 May 24; 131: 2367-2378.

View More Publications

Research

Interests

Host Pathogen Interactions Neutrophil Disorders and NADPH Oxidase Oral Inflammation

Lab(s)

Center for Microbial Pathogenesis

The Bagaitkar laboratory studies the complex interactions between innate immune cells, epithelial cells, and microbial colonizers at mucosal barrier surfaces. Reciprocal and heterogenous interactions between these three entities determine host susceptibility to chronic inflammation, cancers and mucosal infections with bacterial and viral pathogens. The oral mucosal barrier is immunologically complex and serves as a gateway to the respiratory and gastrointestinal mucosal surfaces. It is heavily colonized by a rich and diverse oral microbiome and constantly subject to foreign antigens, allergens and invasion by bacterial and viral pathogens. Thus, the maintenance of immune homeostasis at the oral mucosa is a complex, incompletely understood process. The research projects in the lab are centered around three main areas of focus. 1) Manipulation of host innate immune responses by bacterial and viral pathogens at the oral barrier 2) Regulation of immune effector responses of neutrophil and macrophage 3) Immunodeficiencies that impair neutrophil functional responses and enhance susceptibility to chronic inflammation and autoimmunity (Chronic Granulomatous Disease).

View My Publications

Publications

                  Song Z, Bhattacharya S, Huang G, Greenberg ZJ, Yang W, Bagaitkar J, Schuettpelz L, Dinauer MC. NADPH oxidase 2 limits amplification of IL-1ß-G-CSF axis and an immature neutrophil subset in murine lung inflammation. Blood Adv. 2022 Sep 14;  

                


                  Bhattacharya S, Idol R, Yang W, Rojas Marquez JD, Li Y, Huang G, Beatty W, Atkinson JJ, Brumell J, Bagaitkar J, Magee JA, Dinauer MC. Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice. Blood. 2022 Mar 23;  

                


                  Bagaitkar J. Environment tames CGD macrophages. Blood. 2022 Mar 17; 139: 1611-1612.

                


                  Rodriguez-Hernandez CJ, Sokoloski KJ, Stocke KS, Dukka H, Jin S, Metzler MA, Zaitsev K, Shpak B, Shen D, Miller DP, Artyomov MN, Lamont RJ, Bagaitkar J. Microbiome-mediated incapacitation of interferon lambda production in the oral mucosa. Proc Natl Acad Sci U S A. 2021 Dec 21; 118: 

                


                  Fitzsimonds ZR, Liu C, Stocke KS, Yakoumatos L, Shumway B, Miller DP, Artyomov MN, Bagaitkar J, Lamont RJ. Regulation of olfactomedin 4 by Porphyromonas gingivalis in a community context. ISME J. 2021 Sep; 15: 2627-2642.

                


                  Shchukina I, Bagaitkar J, Shpynov O, Loginicheva E, Porter S, Mogilenko DA, Wolin E, Collins P, Demidov G, Artomov M, Zaitsev K, Sidorov S, Camell C, Bambouskova M, Arthur L, Swain A, Panteleeva A, Dievskii A, Kurbatsky E, Tsurinov P, Chernyatchik R, Dixit VD, Jovanovic M, Stewart SA, Daly MJ, Dmitriev S, Oltz EM, Artyomov MN. Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome. Nat Aging. 2021 Jan; 1: 124-141.

                


                  Zeng MY, Miralda I, Armstrong CL, Uriarte SM, Bagaitkar J. The roles of NADPH oxidase in modulating neutrophil effector responses. Mol Oral Microbiol. 2019 Apr; 34: 27-38.

                


                  Bagaitkar J, Huang J, Zeng MY, Pech NK, Monlish DA, Perez-Zapata LJ, Miralda I, Schuettpelz LG, Dinauer MC. NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood. 2018 May 24; 131: 2367-2378.

View More Publications

Research

Interests

Host Pathogen Interactions Neutrophil Disorders and NADPH Oxidase Oral Inflammation

Lab(s)

Center for Microbial Pathogenesis

The Bagaitkar laboratory studies the complex interactions between innate immune cells, epithelial cells, and microbial colonizers at mucosal barrier surfaces. Reciprocal and heterogenous interactions between these three entities determine host susceptibility to chronic inflammation, cancers and mucosal infections with bacterial and viral pathogens. The oral mucosal barrier is immunologically complex and serves as a gateway to the respiratory and gastrointestinal mucosal surfaces. It is heavily colonized by a rich and diverse oral microbiome and constantly subject to foreign antigens, allergens and invasion by bacterial and viral pathogens. Thus, the maintenance of immune homeostasis at the oral mucosa is a complex, incompletely understood process. The research projects in the lab are centered around three main areas of focus. 1) Manipulation of host innate immune responses by bacterial and viral pathogens at the oral barrier 2) Regulation of immune effector responses of neutrophil and macrophage 3) Immunodeficiencies that impair neutrophil functional responses and enhance susceptibility to chronic inflammation and autoimmunity (Chronic Granulomatous Disease).

View My Publications

Publications

                  Song Z, Bhattacharya S, Huang G, Greenberg ZJ, Yang W, Bagaitkar J, Schuettpelz L, Dinauer MC. NADPH oxidase 2 limits amplification of IL-1ß-G-CSF axis and an immature neutrophil subset in murine lung inflammation. Blood Adv. 2022 Sep 14;  

                


                  Bhattacharya S, Idol R, Yang W, Rojas Marquez JD, Li Y, Huang G, Beatty W, Atkinson JJ, Brumell J, Bagaitkar J, Magee JA, Dinauer MC. Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice. Blood. 2022 Mar 23;  

                


                  Bagaitkar J. Environment tames CGD macrophages. Blood. 2022 Mar 17; 139: 1611-1612.

                


                  Rodriguez-Hernandez CJ, Sokoloski KJ, Stocke KS, Dukka H, Jin S, Metzler MA, Zaitsev K, Shpak B, Shen D, Miller DP, Artyomov MN, Lamont RJ, Bagaitkar J. Microbiome-mediated incapacitation of interferon lambda production in the oral mucosa. Proc Natl Acad Sci U S A. 2021 Dec 21; 118: 

                


                  Fitzsimonds ZR, Liu C, Stocke KS, Yakoumatos L, Shumway B, Miller DP, Artyomov MN, Bagaitkar J, Lamont RJ. Regulation of olfactomedin 4 by Porphyromonas gingivalis in a community context. ISME J. 2021 Sep; 15: 2627-2642.

                


                  Shchukina I, Bagaitkar J, Shpynov O, Loginicheva E, Porter S, Mogilenko DA, Wolin E, Collins P, Demidov G, Artomov M, Zaitsev K, Sidorov S, Camell C, Bambouskova M, Arthur L, Swain A, Panteleeva A, Dievskii A, Kurbatsky E, Tsurinov P, Chernyatchik R, Dixit VD, Jovanovic M, Stewart SA, Daly MJ, Dmitriev S, Oltz EM, Artyomov MN. Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome. Nat Aging. 2021 Jan; 1: 124-141.

                


                  Zeng MY, Miralda I, Armstrong CL, Uriarte SM, Bagaitkar J. The roles of NADPH oxidase in modulating neutrophil effector responses. Mol Oral Microbiol. 2019 Apr; 34: 27-38.

                


                  Bagaitkar J, Huang J, Zeng MY, Pech NK, Monlish DA, Perez-Zapata LJ, Miralda I, Schuettpelz LG, Dinauer MC. NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood. 2018 May 24; 131: 2367-2378.

View More Publications

Interests

Host Pathogen Interactions Neutrophil Disorders and NADPH Oxidase Oral Inflammation

Lab(s)

Center for Microbial Pathogenesis

The Bagaitkar laboratory studies the complex interactions between innate immune cells, epithelial cells, and microbial colonizers at mucosal barrier surfaces. Reciprocal and heterogenous interactions between these three entities determine host susceptibility to chronic inflammation, cancers and mucosal infections with bacterial and viral pathogens. The oral mucosal barrier is immunologically complex and serves as a gateway to the respiratory and gastrointestinal mucosal surfaces. It is heavily colonized by a rich and diverse oral microbiome and constantly subject to foreign antigens, allergens and invasion by bacterial and viral pathogens. Thus, the maintenance of immune homeostasis at the oral mucosa is a complex, incompletely understood process. The research projects in the lab are centered around three main areas of focus. 1) Manipulation of host innate immune responses by bacterial and viral pathogens at the oral barrier 2) Regulation of immune effector responses of neutrophil and macrophage 3) Immunodeficiencies that impair neutrophil functional responses and enhance susceptibility to chronic inflammation and autoimmunity (Chronic Granulomatous Disease).

View My Publications

Publications

                  Song Z, Bhattacharya S, Huang G, Greenberg ZJ, Yang W, Bagaitkar J, Schuettpelz L, Dinauer MC. NADPH oxidase 2 limits amplification of IL-1ß-G-CSF axis and an immature neutrophil subset in murine lung inflammation. Blood Adv. 2022 Sep 14;  

                


                  Bhattacharya S, Idol R, Yang W, Rojas Marquez JD, Li Y, Huang G, Beatty W, Atkinson JJ, Brumell J, Bagaitkar J, Magee JA, Dinauer MC. Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice. Blood. 2022 Mar 23;  

                


                  Bagaitkar J. Environment tames CGD macrophages. Blood. 2022 Mar 17; 139: 1611-1612.

                


                  Rodriguez-Hernandez CJ, Sokoloski KJ, Stocke KS, Dukka H, Jin S, Metzler MA, Zaitsev K, Shpak B, Shen D, Miller DP, Artyomov MN, Lamont RJ, Bagaitkar J. Microbiome-mediated incapacitation of interferon lambda production in the oral mucosa. Proc Natl Acad Sci U S A. 2021 Dec 21; 118: 

                


                  Fitzsimonds ZR, Liu C, Stocke KS, Yakoumatos L, Shumway B, Miller DP, Artyomov MN, Bagaitkar J, Lamont RJ. Regulation of olfactomedin 4 by Porphyromonas gingivalis in a community context. ISME J. 2021 Sep; 15: 2627-2642.

                


                  Shchukina I, Bagaitkar J, Shpynov O, Loginicheva E, Porter S, Mogilenko DA, Wolin E, Collins P, Demidov G, Artomov M, Zaitsev K, Sidorov S, Camell C, Bambouskova M, Arthur L, Swain A, Panteleeva A, Dievskii A, Kurbatsky E, Tsurinov P, Chernyatchik R, Dixit VD, Jovanovic M, Stewart SA, Daly MJ, Dmitriev S, Oltz EM, Artyomov MN. Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome. Nat Aging. 2021 Jan; 1: 124-141.

                


                  Zeng MY, Miralda I, Armstrong CL, Uriarte SM, Bagaitkar J. The roles of NADPH oxidase in modulating neutrophil effector responses. Mol Oral Microbiol. 2019 Apr; 34: 27-38.

                


                  Bagaitkar J, Huang J, Zeng MY, Pech NK, Monlish DA, Perez-Zapata LJ, Miralda I, Schuettpelz LG, Dinauer MC. NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood. 2018 May 24; 131: 2367-2378.

View More Publications

Interests

Host Pathogen Interactions Neutrophil Disorders and NADPH Oxidase Oral Inflammation

Lab(s)

Center for Microbial Pathogenesis

The Bagaitkar laboratory studies the complex interactions between innate immune cells, epithelial cells, and microbial colonizers at mucosal barrier surfaces. Reciprocal and heterogenous interactions between these three entities determine host susceptibility to chronic inflammation, cancers and mucosal infections with bacterial and viral pathogens. The oral mucosal barrier is immunologically complex and serves as a gateway to the respiratory and gastrointestinal mucosal surfaces. It is heavily colonized by a rich and diverse oral microbiome and constantly subject to foreign antigens, allergens and invasion by bacterial and viral pathogens. Thus, the maintenance of immune homeostasis at the oral mucosa is a complex, incompletely understood process. The research projects in the lab are centered around three main areas of focus. 1) Manipulation of host innate immune responses by bacterial and viral pathogens at the oral barrier 2) Regulation of immune effector responses of neutrophil and macrophage 3) Immunodeficiencies that impair neutrophil functional responses and enhance susceptibility to chronic inflammation and autoimmunity (Chronic Granulomatous Disease).

Interests

Host Pathogen Interactions Neutrophil Disorders and NADPH Oxidase Oral Inflammation

Lab(s)

Center for Microbial Pathogenesis

• Host Pathogen Interactions

• Neutrophil Disorders and NADPH Oxidase

• Oral Inflammation

• Center for Microbial Pathogenesis

• View My Publications

                  Song Z, Bhattacharya S, Huang G, Greenberg ZJ, Yang W, Bagaitkar J, Schuettpelz L, Dinauer MC. NADPH oxidase 2 limits amplification of IL-1ß-G-CSF axis and an immature neutrophil subset in murine lung inflammation. Blood Adv. 2022 Sep 14;  
  
  
  
                  Bhattacharya S, Idol R, Yang W, Rojas Marquez JD, Li Y, Huang G, Beatty W, Atkinson JJ, Brumell J, Bagaitkar J, Magee JA, Dinauer MC. Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice. Blood. 2022 Mar 23;  
  
  
  
                  Bagaitkar J. Environment tames CGD macrophages. Blood. 2022 Mar 17; 139: 1611-1612.
  
  
  
                  Rodriguez-Hernandez CJ, Sokoloski KJ, Stocke KS, Dukka H, Jin S, Metzler MA, Zaitsev K, Shpak B, Shen D, Miller DP, Artyomov MN, Lamont RJ, Bagaitkar J. Microbiome-mediated incapacitation of interferon lambda production in the oral mucosa. Proc Natl Acad Sci U S A. 2021 Dec 21; 118: 
  
  
  
                  Fitzsimonds ZR, Liu C, Stocke KS, Yakoumatos L, Shumway B, Miller DP, Artyomov MN, Bagaitkar J, Lamont RJ. Regulation of olfactomedin 4 by Porphyromonas gingivalis in a community context. ISME J. 2021 Sep; 15: 2627-2642.
  
  
  
                  Shchukina I, Bagaitkar J, Shpynov O, Loginicheva E, Porter S, Mogilenko DA, Wolin E, Collins P, Demidov G, Artomov M, Zaitsev K, Sidorov S, Camell C, Bambouskova M, Arthur L, Swain A, Panteleeva A, Dievskii A, Kurbatsky E, Tsurinov P, Chernyatchik R, Dixit VD, Jovanovic M, Stewart SA, Daly MJ, Dmitriev S, Oltz EM, Artyomov MN. Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome. Nat Aging. 2021 Jan; 1: 124-141.
  
  
  
                  Zeng MY, Miralda I, Armstrong CL, Uriarte SM, Bagaitkar J. The roles of NADPH oxidase in modulating neutrophil effector responses. Mol Oral Microbiol. 2019 Apr; 34: 27-38.
  
  
  
                  Bagaitkar J, Huang J, Zeng MY, Pech NK, Monlish DA, Perez-Zapata LJ, Miralda I, Schuettpelz LG, Dinauer MC. NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood. 2018 May 24; 131: 2367-2378.
  
  

View More Publications

• Song Z, Bhattacharya S, Huang G, Greenberg ZJ, Yang W, Bagaitkar J, Schuettpelz L, Dinauer MC. NADPH oxidase 2 limits amplification of IL-1ß-G-CSF axis and an immature neutrophil subset in murine lung inflammation. Blood Adv. 2022 Sep 14;
• Bhattacharya S, Idol R, Yang W, Rojas Marquez JD, Li Y, Huang G, Beatty W, Atkinson JJ, Brumell J, Bagaitkar J, Magee JA, Dinauer MC. Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice. Blood. 2022 Mar 23;
• Bagaitkar J. Environment tames CGD macrophages. Blood. 2022 Mar 17; 139: 1611-1612.
• Rodriguez-Hernandez CJ, Sokoloski KJ, Stocke KS, Dukka H, Jin S, Metzler MA, Zaitsev K, Shpak B, Shen D, Miller DP, Artyomov MN, Lamont RJ, Bagaitkar J. Microbiome-mediated incapacitation of interferon lambda production in the oral mucosa. Proc Natl Acad Sci U S A. 2021 Dec 21; 118:
• Fitzsimonds ZR, Liu C, Stocke KS, Yakoumatos L, Shumway B, Miller DP, Artyomov MN, Bagaitkar J, Lamont RJ. Regulation of olfactomedin 4 by Porphyromonas gingivalis in a community context. ISME J. 2021 Sep; 15: 2627-2642.
• Shchukina I, Bagaitkar J, Shpynov O, Loginicheva E, Porter S, Mogilenko DA, Wolin E, Collins P, Demidov G, Artomov M, Zaitsev K, Sidorov S, Camell C, Bambouskova M, Arthur L, Swain A, Panteleeva A, Dievskii A, Kurbatsky E, Tsurinov P, Chernyatchik R, Dixit VD, Jovanovic M, Stewart SA, Daly MJ, Dmitriev S, Oltz EM, Artyomov MN. Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome. Nat Aging. 2021 Jan; 1: 124-141.
• Zeng MY, Miralda I, Armstrong CL, Uriarte SM, Bagaitkar J. The roles of NADPH oxidase in modulating neutrophil effector responses. Mol Oral Microbiol. 2019 Apr; 34: 27-38.
• Bagaitkar J, Huang J, Zeng MY, Pech NK, Monlish DA, Perez-Zapata LJ, Miralda I, Schuettpelz LG, Dinauer MC. NADPH oxidase activation regulates apoptotic neutrophil clearance by murine macrophages. Blood. 2018 May 24; 131: 2367-2378.

Biography

Juhi Bagaitkar, PhD, is a Principal Investigator in the Center for Microbial Pathogenesis and an Associate Professor in the Department of Pediatrics at The Ohio State University. She is an NIH funded investigator whose research focuses on understanding host-pathogen interactions, and innate immune pathways that regulate tolerogenic immunity at the oral mucosal barrier.

Biography

Juhi Bagaitkar, PhD, is a Principal Investigator in the Center for Microbial Pathogenesis and an Associate Professor in the Department of Pediatrics at The Ohio State University. She is an NIH funded investigator whose research focuses on understanding host-pathogen interactions, and innate immune pathways that regulate tolerogenic immunity at the oral mucosal barrier.

Biography

Juhi Bagaitkar, PhD, is a Principal Investigator in the Center for Microbial Pathogenesis and an Associate Professor in the Department of Pediatrics at The Ohio State University. She is an NIH funded investigator whose research focuses on understanding host-pathogen interactions, and innate immune pathways that regulate tolerogenic immunity at the oral mucosal barrier.

Juhi Bagaitkar, PhD, is a Principal Investigator in the Center for Microbial Pathogenesis and an Associate Professor in the Department of Pediatrics at The Ohio State University. She is an NIH funded investigator whose research focuses on understanding host-pathogen interactions, and innate immune pathways that regulate tolerogenic immunity at the oral mucosal barrier.

Juhi Bagaitkar, PhD, is a Principal Investigator in the Center for Microbial Pathogenesis and an Associate Professor in the Department of Pediatrics at The Ohio State University. She is an NIH funded investigator whose research focuses on understanding host-pathogen interactions, and innate immune pathways that regulate tolerogenic immunity at the oral mucosal barrier.

Academic and Clinical Areas

Center for Microbial Pathogenesis

Principal Investigator

Primary Department

Center for Microbial Pathogenesis

Academic and Clinical Areas

Center for Microbial Pathogenesis

Principal Investigator

Primary Department

Center for Microbial Pathogenesis

Academic and Clinical Areas

Center for Microbial Pathogenesis

Principal Investigator

Primary Department

Center for Microbial Pathogenesis

Center for Microbial Pathogenesis

Principal Investigator

Primary Department

Center for Microbial Pathogenesis

• Center for Microbial Pathogenesis
• Principal Investigator
• Primary Department
• Center for Microbial Pathogenesis

Awards, Honors & Organizations

Associate Councilor, Society for Leukocyte Biology, 2019 Early Career Faculty Award, Society for Leukocyte Biology, Annual meeting, 2018 Adel A. Younis Award for Excellence in Hematology, Washington University School of Medicine, St. Louis, 2014 Guy Stevenson Award for Excellence in Graduate Studies, University of Louisville, 2010 Presidential Award, Society for Leukocyte Biology, Annual Meeting, 2010

Awards, Honors & Organizations

Associate Councilor, Society for Leukocyte Biology, 2019 Early Career Faculty Award, Society for Leukocyte Biology, Annual meeting, 2018 Adel A. Younis Award for Excellence in Hematology, Washington University School of Medicine, St. Louis, 2014 Guy Stevenson Award for Excellence in Graduate Studies, University of Louisville, 2010 Presidential Award, Society for Leukocyte Biology, Annual Meeting, 2010

Awards, Honors & Organizations

Associate Councilor, Society for Leukocyte Biology, 2019 Early Career Faculty Award, Society for Leukocyte Biology, Annual meeting, 2018 Adel A. Younis Award for Excellence in Hematology, Washington University School of Medicine, St. Louis, 2014 Guy Stevenson Award for Excellence in Graduate Studies, University of Louisville, 2010 Presidential Award, Society for Leukocyte Biology, Annual Meeting, 2010

Associate Councilor, Society for Leukocyte Biology, 2019 Early Career Faculty Award, Society for Leukocyte Biology, Annual meeting, 2018 Adel A. Younis Award for Excellence in Hematology, Washington University School of Medicine, St. Louis, 2014 Guy Stevenson Award for Excellence in Graduate Studies, University of Louisville, 2010 Presidential Award, Society for Leukocyte Biology, Annual Meeting, 2010

• Associate Councilor, Society for Leukocyte Biology, 2019
• Early Career Faculty Award, Society for Leukocyte Biology, Annual meeting, 2018
• Adel A. Younis Award for Excellence in Hematology, Washington University School of Medicine, St. Louis, 2014
• Guy Stevenson Award for Excellence in Graduate Studies, University of Louisville, 2010
• Presidential Award, Society for Leukocyte Biology, Annual Meeting, 2010

Education

Post Doctoral

Washington University in St. Louis

Date Completed: 11/30/2016

Graduate School

UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE

Date Completed: 12/10/2010

Education

Post Doctoral

Washington University in St. Louis

Date Completed: 11/30/2016

Graduate School

UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE

Date Completed: 12/10/2010

Education

Post Doctoral

Washington University in St. Louis

Date Completed: 11/30/2016

Graduate School

UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE

Date Completed: 12/10/2010

Post Doctoral

Washington University in St. Louis

Date Completed: 11/30/2016

Graduate School

UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE

Date Completed: 12/10/2010

Post Doctoral

Washington University in St. Louis

Date Completed: 11/30/2016

Graduate School

UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE

Date Completed: 12/10/2010

Professional Experience

2016 - 2021 University of Louisville, Assistant Professor

Professional Experience

2016 - 2021 University of Louisville, Assistant Professor

Professional Experience

2016 - 2021 University of Louisville, Assistant Professor

2016 - 2021 University of Louisville, Assistant Professor

2016 - 2021 University of Louisville, Assistant Professor

Contact Information

Center for Microbial Pathogenesis

Email Juhi Bagaitkar

                    700 Children’s DriveColumbus, OH 43205 (map)

Contact Information

Center for Microbial Pathogenesis

Email Juhi Bagaitkar

                    700 Children’s DriveColumbus, OH 43205 (map)

Contact Information

Center for Microbial Pathogenesis

Email Juhi Bagaitkar

                    700 Children’s DriveColumbus, OH 43205 (map)

Center for Microbial Pathogenesis

Email Juhi Bagaitkar

                    700 Children’s DriveColumbus, OH 43205 (map)

Email Juhi Bagaitkar

                    700 Children’s DriveColumbus, OH 43205 (map)

Email Juhi Bagaitkar

                    700 Children’s DriveColumbus, OH 43205 (map)

• Email Juhi Bagaitkar
• 700 Children’s DriveColumbus, OH 43205 (map)