Jennifer A Muszynski

Contact Information

Call us at: (614) 722-3435

Fax us at: (614) 722-3443

PediatricsCritical Care700 Children’s DrColumbus, OH 43205 (map)

Learn more about Jennifer A. Muszynski

Biography

Jennifer A. Muszynski, MD, MPH, FCCM is an associate professor in the Department of Pediatrics, Division of Critical Care Medicine at Nationwide Children’s Hospital and The Ohio State University College of Medicine. She is the associate program director for research for the Pediatric Critical Care Medicine Fellowship Program.

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Academic and Clinical Areas

Critical Care

Physician Team

Center for Clinical and Translational Research

Principal Investigator

Pediatric Critical Care Fellowship

Associate Program Director

Primary Department

Pediatrics

Primary Section

Critical Care

Awards, Honors & Organizations

Silver Snapshot Award, Society of Critical Care Medicine, 2018 Star Research Achievement Award, Society of Critical Care Medicine, 2016 Young Investigator Coaching Program Award, Society for Pediatric Research, 2013 Presidential Citation, Society of Critical Care Medicine, 2011 Fellow Clinical/Translational Publication Award, Nationwide Children’s Hospital, 2011 Clinical Research Award, Pediatric Critical Care Colloquium, 2010 Chair, Pediatric Critical Care Blood Research Network (BloodNet), 2021 - Present North American Representative, World Federation of Pediatric Intensive and Critical Care Societies Research Consortia Working Group, 2020 - Present Society of Critical Care Medicine Representative, International Collaboration for Transfusion Medicine Guidelines, 2020 - Present Fellow, American College of Critical Care Medicine, 2019 - Present Co-Chair, Pediatric ECMO Anticoagulation Consensus Conferences (PEACE), 2019 - Present Liaison to the Society of Critical Care Medicine, Pediatric Critical Care Transfusion and Anemia Expertise Initiative – Control and Avoidance of Bleeding (TAXI-CAB), 2019 - Present Member, AABB, 2017 - Present Member, Extracorporeal Life Support Organization, 2017 - Present Scientific Committee Member, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), 2017 - Present Co-Chair, Hematology Group, Pediatric Organ Dysfunction Information Update Mandate (PODIUM), 2017 - Present Member, Society for Pediatric Research, 2015 - Present Member, Society of Critical Care Medicine, 2007 - Present Member, American Academy of Pediatrics

Research

Lab(s)

Center for Clinical and Translational Research

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

View My Publications

Publications

                  Steffen KM, Tucci M, Doctor A, Reeder R, Caro JJ, Muszynski JA, Spinella PC, Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The Impact of Restrictive Transfusion Practices on Hemodynamically Stable Critically Ill Children Without Heart Disease: A Secondary Analysis of the Age of Blood in Children in the PICU Trial. Pediatr Crit Care Med. 2023 Feb 1; 24: 84-92.

                


                  Lovett ME, Daniel M, Keesari R, MacDonald J, Rodriguez V, Muszynski J, Sribnick EA, O'Brien NF, Ayad O. Catheter-associated deep vein thrombosis in children with severe traumatic brain injury: A single-center experience. Pediatr Blood Cancer. 2022 Oct 17;  e30044.

                


                  Russell RT, Esparaz JR, Beckwith MA, Abraham PJ, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper C, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Recommendations. J Trauma Acute Care Surg. 2022 Oct 17;  

                


                  Russell RT, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper CM, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Research Priorities. J Trauma Acute Care Surg. 2022 Oct 7;  

                


                  Bline KE, Muszynski JA, Guess AJ, Menocha S, Moore-Clingenpeel MD, Popelka JK, Hensley JM, Steele LM, Goldthwaite IC, Jedreski KJ, Hall MW. Novel Identification of Myeloid-Derived Suppressor Cells in Children With Septic Shock. Pediatr Crit Care Med. 2022 Sep 8;  

                


                  Johnson H, Raees M, Urbina E, Muszynski J, Seydel K, Taylor T, O'Brien N. Multiple Organ Dysfunction Syndrome and Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Cerebral Malaria. Am J Trop Med Hyg. 2022 Sep 6;  

                


                  Thomas KA, Shea SM, Saini A, Muszynski JA, Spinella PC. Correlation between Thrombin Generation, Standard Coagulation Assays, and Viscoelastic Assays for Hemostatic Assessment in Critically Ill Children. J Appl Lab Med. 2022 May 19;  

                


                  Bailly DK, Reeder RW, Muszynski JA, Meert KL, Ankola AA, Alexander PM, Pollack MM, Moler FW, Berg RA, Carcillo J, Newth C, Berger J, Bell MJ, Dean JM, Nicholson C, Garcia-Filion P, Wessel D, Heidemann S, Doctor A, Harrison R, Dalton H, Zuppa AF. Anticoagulation practices associated with bleeding and thrombosis in pediatric extracorporeal membrane oxygenation; a multi-center secondary analysis. Perfusion. 2022 Feb 27;  2676591211056562.

                


                  Traube C, Tucci M, Nellis ME, Avery KL, McQuillen PS, Fitzgerald JC, Muszynski JA, Cholette JM, Schwarz AJ, Stalets EL, Quaid MA, Hanson SJ, Lacroix J, Reeder RW, Spinella PC, Transfusion-Associated Delirium ABC-PICU Study Group.. Transfusion-Associated Delirium in Children: No Difference Between Short Storage Versus Standard Issue RBCs. Crit Care Med. 2022 Feb 1; 50: 173-182.

                


                  Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB). Pediatr Crit Care Med. 2022 Jan 1; 23: 34-51.

                


                  Cholette JM, Muszynski JA, Ibla JC, Emani S, Steiner ME, Vogel AM, Parker RI, Nellis ME, Bembea MM, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Plasma and Platelet Transfusions Strategies in Neonates and Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass or Neonates and Children Supported by Extracorporeal Membrane Oxygenation: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e25-e36.

                


                  Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e1-e13.

                


                  Muszynski JA, Cholette JM, Steiner ME, Tucci M, Doctor A, Parker RI, Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative.. Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1; 149: S74-S78.

                


                  Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yeyha N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. Pediatrics. 2022 Jan 1; 149: S1-S12.

                


                  Muszynski JA, Banks R, Reeder RW, Hall MW, Berg RA, Zuppa A, Shanley TP, Cornell TT, Newth CJL, Pollack MM, Wessel D, Doctor A, Lin JC, Harrison RE, Meert KL, Dean JM, Holubkov R, Carcillo JA, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. Outcomes Associated With Early RBC Transfusion in Pediatric Severe Sepsis: A Propensity-Adjusted Multicenter Cohort Study. Shock. 2022 Jan 1; 57: 88-94.

                


                  Killien EY, Loftis LL, Clark JD, Muszynski JA, Rissmiller BJ, Singleton MN, White BR, Zimmerman JJ, Maddux AB, Pinto NP, Fink EL, Watson RS, Smith M, Ringwood M, Graham RJ, POST-PICU and PICU-COS Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Networks.. Health-related quality of life outcome measures for children surviving critical care: a scoping review. Qual Life Res. 2021 Dec; 30: 3383-3394.

                


                  Relland LM, Hall M, Martin DP, Nateri J, Hanson-Huber L, Beebe A, Samora W, Klamar J, Muszynski J, Tobias JD. Immune Function following Major Spinal Surgery and General Anesthesia. J Pediatr Intensive Care. 2021 Nov; 10: 248-255.

                


                  Leonard JC, Josephson CD, Luther JF, Wisniewski SR, Allen C, Chiusolo F, Davis AL, Finkelstein RA, Fitzgerald JC, Gaines BA, Goobie SM, Hanson SJ, Hewes HA, Johnson LH, McCollum MO, Muszynski JA, Nair AB, Rosenberg RB, Rouse TM, Sikavitsas A, Singleton MN, Steiner ME, Upperman JS, Vogel AM, Wills H, Winkler MK, Spinella PC. Life-Threatening Bleeding in Children: A Prospective Observational Study. Crit Care Med. 2021 Nov 1; 49: 1943-1954.

                


                  Alexander PMA, Muszynski JA. Ongoing Variability in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation Practices-Could Consensus Change the Next Survey Results? Pediatr Crit Care Med. 2021 Jun 1; 22: 581-584.

                


                  Snyder A, Jedreski K, Fitch J, Wijeratne S, Wetzel A, Hensley J, Flowers M, Bline K, Hall MW, Muszynski JA. Transcriptomic Profiles in Children With Septic Shock With or Without Immunoparalysis. Front Immunol. 2021; 12: 733834.

                


                  Juffermans NP, Aubron C, Duranteau J, Vlaar APJ, Kor DJ, Muszynski JA, Spinella PC, Vincent JL. Transfusion in the mechanically ventilated patient. Intensive Care Med. 2020 Dec; 46: 2450-2457.

                


                  Thakkar RK, Devine R, Popelka J, Hensley J, Fabia R, Muszynski JA, Hall MW. Measures of Systemic Innate Immune Function Predict the Risk of Nosocomial Infection in Pediatric Burn Patients. J Burn Care Res. 2020 Oct 31;  

                


                  Bline KE, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Muszynski JA, Ramilo O, Hall MW. Hydrocortisone treatment is associated with a longer duration of MODS in pediatric patients with severe sepsis and immunoparalysis. Crit Care. 2020 Sep 4; 24: 545.

                


                  Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion. 2020 Aug 29;  267659120952982.

                


                  Srouji LS, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Nicol K, Hall MW, Ramilo O, Muszynski JA. Shock Severity Modifies Associations Between RBC Transfusion in the First 48 Hours of Sepsis Onset and the Duration of Organ Dysfunction in Critically Ill Septic Children. Pediatr Crit Care Med. 2020 Aug; 21: e475-e484.

                


                  Wirtz MR, Almizraq RJ, Weber NC, Norris PJ, Pandey S, Spinella PC, Muszynski JA, P Acker J, Juffermans NP. Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation. Vox Sang. 2020 Jul; 115: 395-404.

                


                  Sribnick EA, Hensley J, Moore-Clingenpeel M, Muszynski JA, Thakkar RK, Hall MW. Nosocomial Infection Following Severe Traumatic Injury in Children. Pediatr Crit Care Med. 2020 May; 21: 443-450.

                


                  Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF, ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P.. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019 Dec 10; 322: 2179-2190.

                


                  Menocha S, Muszynski JA. Transfusion-related immune modulation: functional consequence of extracellular vesicles? Transfusion. 2019 Jul 19;  

                


                  Thakkar RK, Weiss SL, Fitzgerald JC, Keele L, Thomas NJ, Nadkarni VM, Muszynski JA, Hall MW, SPROUT Investigators., Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis. J Surg Res. 2019 May 7; 242: 100-110.

                


                  Wirtz MR, Jurgens J, Zuurbier CJ, Roelofs JJTH, Spinella PC, Muszynski JA, Carel Goslings J, Juffermans NP. Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion. Transfusion. 2019 Jan; 59: 134-145.

                


                  Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: 884-898.

                


                  Muszynski JA, Guzzetta NA, Hall MW, Macrae D, Valentine SL, Bateman ST, Spinella PC, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (Blood Net), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: S121-S126.

                


                  Almizraq RJ, Norris PJ, Inglis H, Menocha S, Wirtz MR, Juffermans N, Pandey S, Spinella PC, Acker JP, Muszynski JA. Blood manufacturing methods affect red blood cell product characteristics and immunomodulatory activity. Blood Adv. 2018 Sep 25; 2: 2296-2306.

                


                  Muszynski JA, Nofziger R, Moore-Clingenpeel M, Greathouse K, Anglim L, Steele L, Hensley J, Hanson-Huber L, Nateri J, Ramilo O, Hall MW. Early Immune Function and Duration of Organ Dysfunction in Critically III Children with Sepsis. Am J Respir Crit Care Med. 2018 Aug 1; 198: 361-369.

                


                  Muszynski JA, Reeder RW, Hall MW, Berg RA, Shanley TP, Newth CJL, Pollack MM, Wessel D, Carcillo J, Harrison R, Meert KL, Dean JM, Jenkins T, Tamburro RF, Dalton HJ, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support. Crit Care Med. 2018 Jun; 46: e552-e559.

                


                  Shah S, Coppolino K, Menocha S, Beceiro S, Nateri J, Spinella PC, Nicol K, Hall MW, Muszynski JA, investigators of the PALISI BloodNet network.. Immunomodulatory effects of plasma products on monocyte function in vitro. J Trauma Acute Care Surg. 2018 Jun; 84: S47-S53.

                


                  Remy KE, Hall MW, Cholette J, Juffermans NP, Nicol K, Doctor A, Blumberg N, Spinella PC, Norris PJ, Dahmer MK, Muszynski JA, Pediatric Critical Care Blood Research Network (Blood Net).. Mechanisms of red blood cell transfusion-related immunomodulation. Transfusion. 2018 Mar; 58: 804-815.

                


                  Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. Transfusion. 2018 Jan; 58: 255-266.

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Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2007

Board Certifications

Pediatric Critical Care Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2007

Medical School

Medical College of Ohio at Toledo

Date Completed: 06/04/2004

Contact Information

Pediatrics

Call us at: (614) 722-3435

Fax us at: (614) 722-3443

                    Critical Care700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-3435

Fax us at: (614) 722-3443

PediatricsCritical Care700 Children’s DrColumbus, OH 43205 (map)

Learn more about Jennifer A. Muszynski

Biography

Jennifer A. Muszynski, MD, MPH, FCCM is an associate professor in the Department of Pediatrics, Division of Critical Care Medicine at Nationwide Children’s Hospital and The Ohio State University College of Medicine. She is the associate program director for research for the Pediatric Critical Care Medicine Fellowship Program.

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Academic and Clinical Areas

Critical Care

Physician Team

Center for Clinical and Translational Research

Principal Investigator

Pediatric Critical Care Fellowship

Associate Program Director

Primary Department

Pediatrics

Primary Section

Critical Care

Awards, Honors & Organizations

Silver Snapshot Award, Society of Critical Care Medicine, 2018 Star Research Achievement Award, Society of Critical Care Medicine, 2016 Young Investigator Coaching Program Award, Society for Pediatric Research, 2013 Presidential Citation, Society of Critical Care Medicine, 2011 Fellow Clinical/Translational Publication Award, Nationwide Children’s Hospital, 2011 Clinical Research Award, Pediatric Critical Care Colloquium, 2010 Chair, Pediatric Critical Care Blood Research Network (BloodNet), 2021 - Present North American Representative, World Federation of Pediatric Intensive and Critical Care Societies Research Consortia Working Group, 2020 - Present Society of Critical Care Medicine Representative, International Collaboration for Transfusion Medicine Guidelines, 2020 - Present Fellow, American College of Critical Care Medicine, 2019 - Present Co-Chair, Pediatric ECMO Anticoagulation Consensus Conferences (PEACE), 2019 - Present Liaison to the Society of Critical Care Medicine, Pediatric Critical Care Transfusion and Anemia Expertise Initiative – Control and Avoidance of Bleeding (TAXI-CAB), 2019 - Present Member, AABB, 2017 - Present Member, Extracorporeal Life Support Organization, 2017 - Present Scientific Committee Member, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), 2017 - Present Co-Chair, Hematology Group, Pediatric Organ Dysfunction Information Update Mandate (PODIUM), 2017 - Present Member, Society for Pediatric Research, 2015 - Present Member, Society of Critical Care Medicine, 2007 - Present Member, American Academy of Pediatrics

Research

Lab(s)

Center for Clinical and Translational Research

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

View My Publications

Publications

                  Steffen KM, Tucci M, Doctor A, Reeder R, Caro JJ, Muszynski JA, Spinella PC, Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The Impact of Restrictive Transfusion Practices on Hemodynamically Stable Critically Ill Children Without Heart Disease: A Secondary Analysis of the Age of Blood in Children in the PICU Trial. Pediatr Crit Care Med. 2023 Feb 1; 24: 84-92.

                


                  Lovett ME, Daniel M, Keesari R, MacDonald J, Rodriguez V, Muszynski J, Sribnick EA, O'Brien NF, Ayad O. Catheter-associated deep vein thrombosis in children with severe traumatic brain injury: A single-center experience. Pediatr Blood Cancer. 2022 Oct 17;  e30044.

                


                  Russell RT, Esparaz JR, Beckwith MA, Abraham PJ, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper C, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Recommendations. J Trauma Acute Care Surg. 2022 Oct 17;  

                


                  Russell RT, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper CM, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Research Priorities. J Trauma Acute Care Surg. 2022 Oct 7;  

                


                  Bline KE, Muszynski JA, Guess AJ, Menocha S, Moore-Clingenpeel MD, Popelka JK, Hensley JM, Steele LM, Goldthwaite IC, Jedreski KJ, Hall MW. Novel Identification of Myeloid-Derived Suppressor Cells in Children With Septic Shock. Pediatr Crit Care Med. 2022 Sep 8;  

                


                  Johnson H, Raees M, Urbina E, Muszynski J, Seydel K, Taylor T, O'Brien N. Multiple Organ Dysfunction Syndrome and Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Cerebral Malaria. Am J Trop Med Hyg. 2022 Sep 6;  

                


                  Thomas KA, Shea SM, Saini A, Muszynski JA, Spinella PC. Correlation between Thrombin Generation, Standard Coagulation Assays, and Viscoelastic Assays for Hemostatic Assessment in Critically Ill Children. J Appl Lab Med. 2022 May 19;  

                


                  Bailly DK, Reeder RW, Muszynski JA, Meert KL, Ankola AA, Alexander PM, Pollack MM, Moler FW, Berg RA, Carcillo J, Newth C, Berger J, Bell MJ, Dean JM, Nicholson C, Garcia-Filion P, Wessel D, Heidemann S, Doctor A, Harrison R, Dalton H, Zuppa AF. Anticoagulation practices associated with bleeding and thrombosis in pediatric extracorporeal membrane oxygenation; a multi-center secondary analysis. Perfusion. 2022 Feb 27;  2676591211056562.

                


                  Traube C, Tucci M, Nellis ME, Avery KL, McQuillen PS, Fitzgerald JC, Muszynski JA, Cholette JM, Schwarz AJ, Stalets EL, Quaid MA, Hanson SJ, Lacroix J, Reeder RW, Spinella PC, Transfusion-Associated Delirium ABC-PICU Study Group.. Transfusion-Associated Delirium in Children: No Difference Between Short Storage Versus Standard Issue RBCs. Crit Care Med. 2022 Feb 1; 50: 173-182.

                


                  Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB). Pediatr Crit Care Med. 2022 Jan 1; 23: 34-51.

                


                  Cholette JM, Muszynski JA, Ibla JC, Emani S, Steiner ME, Vogel AM, Parker RI, Nellis ME, Bembea MM, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Plasma and Platelet Transfusions Strategies in Neonates and Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass or Neonates and Children Supported by Extracorporeal Membrane Oxygenation: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e25-e36.

                


                  Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e1-e13.

                


                  Muszynski JA, Cholette JM, Steiner ME, Tucci M, Doctor A, Parker RI, Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative.. Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1; 149: S74-S78.

                


                  Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yeyha N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. Pediatrics. 2022 Jan 1; 149: S1-S12.

                


                  Muszynski JA, Banks R, Reeder RW, Hall MW, Berg RA, Zuppa A, Shanley TP, Cornell TT, Newth CJL, Pollack MM, Wessel D, Doctor A, Lin JC, Harrison RE, Meert KL, Dean JM, Holubkov R, Carcillo JA, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. Outcomes Associated With Early RBC Transfusion in Pediatric Severe Sepsis: A Propensity-Adjusted Multicenter Cohort Study. Shock. 2022 Jan 1; 57: 88-94.

                


                  Killien EY, Loftis LL, Clark JD, Muszynski JA, Rissmiller BJ, Singleton MN, White BR, Zimmerman JJ, Maddux AB, Pinto NP, Fink EL, Watson RS, Smith M, Ringwood M, Graham RJ, POST-PICU and PICU-COS Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Networks.. Health-related quality of life outcome measures for children surviving critical care: a scoping review. Qual Life Res. 2021 Dec; 30: 3383-3394.

                


                  Relland LM, Hall M, Martin DP, Nateri J, Hanson-Huber L, Beebe A, Samora W, Klamar J, Muszynski J, Tobias JD. Immune Function following Major Spinal Surgery and General Anesthesia. J Pediatr Intensive Care. 2021 Nov; 10: 248-255.

                


                  Leonard JC, Josephson CD, Luther JF, Wisniewski SR, Allen C, Chiusolo F, Davis AL, Finkelstein RA, Fitzgerald JC, Gaines BA, Goobie SM, Hanson SJ, Hewes HA, Johnson LH, McCollum MO, Muszynski JA, Nair AB, Rosenberg RB, Rouse TM, Sikavitsas A, Singleton MN, Steiner ME, Upperman JS, Vogel AM, Wills H, Winkler MK, Spinella PC. Life-Threatening Bleeding in Children: A Prospective Observational Study. Crit Care Med. 2021 Nov 1; 49: 1943-1954.

                


                  Alexander PMA, Muszynski JA. Ongoing Variability in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation Practices-Could Consensus Change the Next Survey Results? Pediatr Crit Care Med. 2021 Jun 1; 22: 581-584.

                


                  Snyder A, Jedreski K, Fitch J, Wijeratne S, Wetzel A, Hensley J, Flowers M, Bline K, Hall MW, Muszynski JA. Transcriptomic Profiles in Children With Septic Shock With or Without Immunoparalysis. Front Immunol. 2021; 12: 733834.

                


                  Juffermans NP, Aubron C, Duranteau J, Vlaar APJ, Kor DJ, Muszynski JA, Spinella PC, Vincent JL. Transfusion in the mechanically ventilated patient. Intensive Care Med. 2020 Dec; 46: 2450-2457.

                


                  Thakkar RK, Devine R, Popelka J, Hensley J, Fabia R, Muszynski JA, Hall MW. Measures of Systemic Innate Immune Function Predict the Risk of Nosocomial Infection in Pediatric Burn Patients. J Burn Care Res. 2020 Oct 31;  

                


                  Bline KE, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Muszynski JA, Ramilo O, Hall MW. Hydrocortisone treatment is associated with a longer duration of MODS in pediatric patients with severe sepsis and immunoparalysis. Crit Care. 2020 Sep 4; 24: 545.

                


                  Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion. 2020 Aug 29;  267659120952982.

                


                  Srouji LS, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Nicol K, Hall MW, Ramilo O, Muszynski JA. Shock Severity Modifies Associations Between RBC Transfusion in the First 48 Hours of Sepsis Onset and the Duration of Organ Dysfunction in Critically Ill Septic Children. Pediatr Crit Care Med. 2020 Aug; 21: e475-e484.

                


                  Wirtz MR, Almizraq RJ, Weber NC, Norris PJ, Pandey S, Spinella PC, Muszynski JA, P Acker J, Juffermans NP. Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation. Vox Sang. 2020 Jul; 115: 395-404.

                


                  Sribnick EA, Hensley J, Moore-Clingenpeel M, Muszynski JA, Thakkar RK, Hall MW. Nosocomial Infection Following Severe Traumatic Injury in Children. Pediatr Crit Care Med. 2020 May; 21: 443-450.

                


                  Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF, ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P.. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019 Dec 10; 322: 2179-2190.

                


                  Menocha S, Muszynski JA. Transfusion-related immune modulation: functional consequence of extracellular vesicles? Transfusion. 2019 Jul 19;  

                


                  Thakkar RK, Weiss SL, Fitzgerald JC, Keele L, Thomas NJ, Nadkarni VM, Muszynski JA, Hall MW, SPROUT Investigators., Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis. J Surg Res. 2019 May 7; 242: 100-110.

                


                  Wirtz MR, Jurgens J, Zuurbier CJ, Roelofs JJTH, Spinella PC, Muszynski JA, Carel Goslings J, Juffermans NP. Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion. Transfusion. 2019 Jan; 59: 134-145.

                


                  Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: 884-898.

                


                  Muszynski JA, Guzzetta NA, Hall MW, Macrae D, Valentine SL, Bateman ST, Spinella PC, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (Blood Net), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: S121-S126.

                


                  Almizraq RJ, Norris PJ, Inglis H, Menocha S, Wirtz MR, Juffermans N, Pandey S, Spinella PC, Acker JP, Muszynski JA. Blood manufacturing methods affect red blood cell product characteristics and immunomodulatory activity. Blood Adv. 2018 Sep 25; 2: 2296-2306.

                


                  Muszynski JA, Nofziger R, Moore-Clingenpeel M, Greathouse K, Anglim L, Steele L, Hensley J, Hanson-Huber L, Nateri J, Ramilo O, Hall MW. Early Immune Function and Duration of Organ Dysfunction in Critically III Children with Sepsis. Am J Respir Crit Care Med. 2018 Aug 1; 198: 361-369.

                


                  Muszynski JA, Reeder RW, Hall MW, Berg RA, Shanley TP, Newth CJL, Pollack MM, Wessel D, Carcillo J, Harrison R, Meert KL, Dean JM, Jenkins T, Tamburro RF, Dalton HJ, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support. Crit Care Med. 2018 Jun; 46: e552-e559.

                


                  Shah S, Coppolino K, Menocha S, Beceiro S, Nateri J, Spinella PC, Nicol K, Hall MW, Muszynski JA, investigators of the PALISI BloodNet network.. Immunomodulatory effects of plasma products on monocyte function in vitro. J Trauma Acute Care Surg. 2018 Jun; 84: S47-S53.

                


                  Remy KE, Hall MW, Cholette J, Juffermans NP, Nicol K, Doctor A, Blumberg N, Spinella PC, Norris PJ, Dahmer MK, Muszynski JA, Pediatric Critical Care Blood Research Network (Blood Net).. Mechanisms of red blood cell transfusion-related immunomodulation. Transfusion. 2018 Mar; 58: 804-815.

                


                  Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. Transfusion. 2018 Jan; 58: 255-266.

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2007

Board Certifications

Pediatric Critical Care Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2007

Medical School

Medical College of Ohio at Toledo

Date Completed: 06/04/2004

Contact Information

Pediatrics

Call us at: (614) 722-3435

Fax us at: (614) 722-3443

                    Critical Care700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-3435

Fax us at: (614) 722-3443

PediatricsCritical Care700 Children’s DrColumbus, OH 43205 (map)

Learn more about Jennifer A. Muszynski

Contact Information

• Call us at:
• (614) 722-3435
• Fax us at:
• (614) 722-3443
• PediatricsCritical Care700 Children’s DrColumbus, OH 43205 (map)

Learn more about Jennifer A. Muszynski

Biography

Jennifer A. Muszynski, MD, MPH, FCCM is an associate professor in the Department of Pediatrics, Division of Critical Care Medicine at Nationwide Children’s Hospital and The Ohio State University College of Medicine. She is the associate program director for research for the Pediatric Critical Care Medicine Fellowship Program.

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

Biography

Jennifer A. Muszynski, MD, MPH, FCCM is an associate professor in the Department of Pediatrics, Division of Critical Care Medicine at Nationwide Children’s Hospital and The Ohio State University College of Medicine. She is the associate program director for research for the Pediatric Critical Care Medicine Fellowship Program.

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

Biography

Jennifer A. Muszynski, MD, MPH, FCCM is an associate professor in the Department of Pediatrics, Division of Critical Care Medicine at Nationwide Children’s Hospital and The Ohio State University College of Medicine. She is the associate program director for research for the Pediatric Critical Care Medicine Fellowship Program.

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

Jennifer A. Muszynski, MD, MPH, FCCM is an associate professor in the Department of Pediatrics, Division of Critical Care Medicine at Nationwide Children’s Hospital and The Ohio State University College of Medicine. She is the associate program director for research for the Pediatric Critical Care Medicine Fellowship Program.

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

Jennifer A. Muszynski, MD, MPH, FCCM is an associate professor in the Department of Pediatrics, Division of Critical Care Medicine at Nationwide Children’s Hospital and The Ohio State University College of Medicine. She is the associate program director for research for the Pediatric Critical Care Medicine Fellowship Program.

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Locations

Main Campus of Nationwide Children’s Hospital

Locations

Main Campus of Nationwide Children’s Hospital

Locations

Main Campus of Nationwide Children’s Hospital

• Main Campus of Nationwide Children’s Hospital

Academic and Clinical Areas

Critical Care

Physician Team

Center for Clinical and Translational Research

Principal Investigator

Pediatric Critical Care Fellowship

Associate Program Director

Primary Department

Pediatrics

Primary Section

Critical Care

Academic and Clinical Areas

Critical Care

Physician Team

Center for Clinical and Translational Research

Principal Investigator

Pediatric Critical Care Fellowship

Associate Program Director

Primary Department

Pediatrics

Primary Section

Critical Care

Academic and Clinical Areas

Critical Care

Physician Team

Center for Clinical and Translational Research

Principal Investigator

Pediatric Critical Care Fellowship

Associate Program Director

Primary Department

Pediatrics

Primary Section

Critical Care

Critical Care

Physician Team

Center for Clinical and Translational Research

Principal Investigator

Pediatric Critical Care Fellowship

Associate Program Director

Primary Department

Pediatrics

Primary Section

Critical Care

• Critical Care
• Physician Team
• Center for Clinical and Translational Research
• Principal Investigator
• Pediatric Critical Care Fellowship
• Associate Program Director
• Primary Department
• Pediatrics
• Primary Section
• Critical Care

Awards, Honors & Organizations

Silver Snapshot Award, Society of Critical Care Medicine, 2018 Star Research Achievement Award, Society of Critical Care Medicine, 2016 Young Investigator Coaching Program Award, Society for Pediatric Research, 2013 Presidential Citation, Society of Critical Care Medicine, 2011 Fellow Clinical/Translational Publication Award, Nationwide Children’s Hospital, 2011 Clinical Research Award, Pediatric Critical Care Colloquium, 2010 Chair, Pediatric Critical Care Blood Research Network (BloodNet), 2021 - Present North American Representative, World Federation of Pediatric Intensive and Critical Care Societies Research Consortia Working Group, 2020 - Present Society of Critical Care Medicine Representative, International Collaboration for Transfusion Medicine Guidelines, 2020 - Present Fellow, American College of Critical Care Medicine, 2019 - Present Co-Chair, Pediatric ECMO Anticoagulation Consensus Conferences (PEACE), 2019 - Present Liaison to the Society of Critical Care Medicine, Pediatric Critical Care Transfusion and Anemia Expertise Initiative – Control and Avoidance of Bleeding (TAXI-CAB), 2019 - Present Member, AABB, 2017 - Present Member, Extracorporeal Life Support Organization, 2017 - Present Scientific Committee Member, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), 2017 - Present Co-Chair, Hematology Group, Pediatric Organ Dysfunction Information Update Mandate (PODIUM), 2017 - Present Member, Society for Pediatric Research, 2015 - Present Member, Society of Critical Care Medicine, 2007 - Present Member, American Academy of Pediatrics

Awards, Honors & Organizations

Silver Snapshot Award, Society of Critical Care Medicine, 2018 Star Research Achievement Award, Society of Critical Care Medicine, 2016 Young Investigator Coaching Program Award, Society for Pediatric Research, 2013 Presidential Citation, Society of Critical Care Medicine, 2011 Fellow Clinical/Translational Publication Award, Nationwide Children’s Hospital, 2011 Clinical Research Award, Pediatric Critical Care Colloquium, 2010 Chair, Pediatric Critical Care Blood Research Network (BloodNet), 2021 - Present North American Representative, World Federation of Pediatric Intensive and Critical Care Societies Research Consortia Working Group, 2020 - Present Society of Critical Care Medicine Representative, International Collaboration for Transfusion Medicine Guidelines, 2020 - Present Fellow, American College of Critical Care Medicine, 2019 - Present Co-Chair, Pediatric ECMO Anticoagulation Consensus Conferences (PEACE), 2019 - Present Liaison to the Society of Critical Care Medicine, Pediatric Critical Care Transfusion and Anemia Expertise Initiative – Control and Avoidance of Bleeding (TAXI-CAB), 2019 - Present Member, AABB, 2017 - Present Member, Extracorporeal Life Support Organization, 2017 - Present Scientific Committee Member, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), 2017 - Present Co-Chair, Hematology Group, Pediatric Organ Dysfunction Information Update Mandate (PODIUM), 2017 - Present Member, Society for Pediatric Research, 2015 - Present Member, Society of Critical Care Medicine, 2007 - Present Member, American Academy of Pediatrics

Awards, Honors & Organizations

Silver Snapshot Award, Society of Critical Care Medicine, 2018 Star Research Achievement Award, Society of Critical Care Medicine, 2016 Young Investigator Coaching Program Award, Society for Pediatric Research, 2013 Presidential Citation, Society of Critical Care Medicine, 2011 Fellow Clinical/Translational Publication Award, Nationwide Children’s Hospital, 2011 Clinical Research Award, Pediatric Critical Care Colloquium, 2010 Chair, Pediatric Critical Care Blood Research Network (BloodNet), 2021 - Present North American Representative, World Federation of Pediatric Intensive and Critical Care Societies Research Consortia Working Group, 2020 - Present Society of Critical Care Medicine Representative, International Collaboration for Transfusion Medicine Guidelines, 2020 - Present Fellow, American College of Critical Care Medicine, 2019 - Present Co-Chair, Pediatric ECMO Anticoagulation Consensus Conferences (PEACE), 2019 - Present Liaison to the Society of Critical Care Medicine, Pediatric Critical Care Transfusion and Anemia Expertise Initiative – Control and Avoidance of Bleeding (TAXI-CAB), 2019 - Present Member, AABB, 2017 - Present Member, Extracorporeal Life Support Organization, 2017 - Present Scientific Committee Member, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), 2017 - Present Co-Chair, Hematology Group, Pediatric Organ Dysfunction Information Update Mandate (PODIUM), 2017 - Present Member, Society for Pediatric Research, 2015 - Present Member, Society of Critical Care Medicine, 2007 - Present Member, American Academy of Pediatrics

Silver Snapshot Award, Society of Critical Care Medicine, 2018 Star Research Achievement Award, Society of Critical Care Medicine, 2016 Young Investigator Coaching Program Award, Society for Pediatric Research, 2013 Presidential Citation, Society of Critical Care Medicine, 2011 Fellow Clinical/Translational Publication Award, Nationwide Children’s Hospital, 2011 Clinical Research Award, Pediatric Critical Care Colloquium, 2010 Chair, Pediatric Critical Care Blood Research Network (BloodNet), 2021 - Present North American Representative, World Federation of Pediatric Intensive and Critical Care Societies Research Consortia Working Group, 2020 - Present Society of Critical Care Medicine Representative, International Collaboration for Transfusion Medicine Guidelines, 2020 - Present Fellow, American College of Critical Care Medicine, 2019 - Present Co-Chair, Pediatric ECMO Anticoagulation Consensus Conferences (PEACE), 2019 - Present Liaison to the Society of Critical Care Medicine, Pediatric Critical Care Transfusion and Anemia Expertise Initiative – Control and Avoidance of Bleeding (TAXI-CAB), 2019 - Present Member, AABB, 2017 - Present Member, Extracorporeal Life Support Organization, 2017 - Present Scientific Committee Member, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), 2017 - Present Co-Chair, Hematology Group, Pediatric Organ Dysfunction Information Update Mandate (PODIUM), 2017 - Present Member, Society for Pediatric Research, 2015 - Present Member, Society of Critical Care Medicine, 2007 - Present Member, American Academy of Pediatrics

• Silver Snapshot Award, Society of Critical Care Medicine, 2018
• Star Research Achievement Award, Society of Critical Care Medicine, 2016
• Young Investigator Coaching Program Award, Society for Pediatric Research, 2013
• Presidential Citation, Society of Critical Care Medicine, 2011
• Fellow Clinical/Translational Publication Award, Nationwide Children’s Hospital, 2011
• Clinical Research Award, Pediatric Critical Care Colloquium, 2010
• Chair, Pediatric Critical Care Blood Research Network (BloodNet), 2021 - Present
• North American Representative, World Federation of Pediatric Intensive and Critical Care Societies Research Consortia Working Group, 2020 - Present
• Society of Critical Care Medicine Representative, International Collaboration for Transfusion Medicine Guidelines, 2020 - Present
• Fellow, American College of Critical Care Medicine, 2019 - Present
• Co-Chair, Pediatric ECMO Anticoagulation Consensus Conferences (PEACE), 2019 - Present
• Liaison to the Society of Critical Care Medicine, Pediatric Critical Care Transfusion and Anemia Expertise Initiative – Control and Avoidance of Bleeding (TAXI-CAB), 2019 - Present
• Member, AABB, 2017 - Present
• Member, Extracorporeal Life Support Organization, 2017 - Present
• Scientific Committee Member, Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), 2017 - Present
• Co-Chair, Hematology Group, Pediatric Organ Dysfunction Information Update Mandate (PODIUM), 2017 - Present
• Member, Society for Pediatric Research, 2015 - Present
• Member, Society of Critical Care Medicine, 2007 - Present
• Member, American Academy of Pediatrics

Research

Lab(s)

Center for Clinical and Translational Research

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

View My Publications

Publications

                  Steffen KM, Tucci M, Doctor A, Reeder R, Caro JJ, Muszynski JA, Spinella PC, Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The Impact of Restrictive Transfusion Practices on Hemodynamically Stable Critically Ill Children Without Heart Disease: A Secondary Analysis of the Age of Blood in Children in the PICU Trial. Pediatr Crit Care Med. 2023 Feb 1; 24: 84-92.

                


                  Lovett ME, Daniel M, Keesari R, MacDonald J, Rodriguez V, Muszynski J, Sribnick EA, O'Brien NF, Ayad O. Catheter-associated deep vein thrombosis in children with severe traumatic brain injury: A single-center experience. Pediatr Blood Cancer. 2022 Oct 17;  e30044.

                


                  Russell RT, Esparaz JR, Beckwith MA, Abraham PJ, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper C, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Recommendations. J Trauma Acute Care Surg. 2022 Oct 17;  

                


                  Russell RT, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper CM, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Research Priorities. J Trauma Acute Care Surg. 2022 Oct 7;  

                


                  Bline KE, Muszynski JA, Guess AJ, Menocha S, Moore-Clingenpeel MD, Popelka JK, Hensley JM, Steele LM, Goldthwaite IC, Jedreski KJ, Hall MW. Novel Identification of Myeloid-Derived Suppressor Cells in Children With Septic Shock. Pediatr Crit Care Med. 2022 Sep 8;  

                


                  Johnson H, Raees M, Urbina E, Muszynski J, Seydel K, Taylor T, O'Brien N. Multiple Organ Dysfunction Syndrome and Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Cerebral Malaria. Am J Trop Med Hyg. 2022 Sep 6;  

                


                  Thomas KA, Shea SM, Saini A, Muszynski JA, Spinella PC. Correlation between Thrombin Generation, Standard Coagulation Assays, and Viscoelastic Assays for Hemostatic Assessment in Critically Ill Children. J Appl Lab Med. 2022 May 19;  

                


                  Bailly DK, Reeder RW, Muszynski JA, Meert KL, Ankola AA, Alexander PM, Pollack MM, Moler FW, Berg RA, Carcillo J, Newth C, Berger J, Bell MJ, Dean JM, Nicholson C, Garcia-Filion P, Wessel D, Heidemann S, Doctor A, Harrison R, Dalton H, Zuppa AF. Anticoagulation practices associated with bleeding and thrombosis in pediatric extracorporeal membrane oxygenation; a multi-center secondary analysis. Perfusion. 2022 Feb 27;  2676591211056562.

                


                  Traube C, Tucci M, Nellis ME, Avery KL, McQuillen PS, Fitzgerald JC, Muszynski JA, Cholette JM, Schwarz AJ, Stalets EL, Quaid MA, Hanson SJ, Lacroix J, Reeder RW, Spinella PC, Transfusion-Associated Delirium ABC-PICU Study Group.. Transfusion-Associated Delirium in Children: No Difference Between Short Storage Versus Standard Issue RBCs. Crit Care Med. 2022 Feb 1; 50: 173-182.

                


                  Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB). Pediatr Crit Care Med. 2022 Jan 1; 23: 34-51.

                


                  Cholette JM, Muszynski JA, Ibla JC, Emani S, Steiner ME, Vogel AM, Parker RI, Nellis ME, Bembea MM, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Plasma and Platelet Transfusions Strategies in Neonates and Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass or Neonates and Children Supported by Extracorporeal Membrane Oxygenation: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e25-e36.

                


                  Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e1-e13.

                


                  Muszynski JA, Cholette JM, Steiner ME, Tucci M, Doctor A, Parker RI, Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative.. Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1; 149: S74-S78.

                


                  Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yeyha N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. Pediatrics. 2022 Jan 1; 149: S1-S12.

                


                  Muszynski JA, Banks R, Reeder RW, Hall MW, Berg RA, Zuppa A, Shanley TP, Cornell TT, Newth CJL, Pollack MM, Wessel D, Doctor A, Lin JC, Harrison RE, Meert KL, Dean JM, Holubkov R, Carcillo JA, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. Outcomes Associated With Early RBC Transfusion in Pediatric Severe Sepsis: A Propensity-Adjusted Multicenter Cohort Study. Shock. 2022 Jan 1; 57: 88-94.

                


                  Killien EY, Loftis LL, Clark JD, Muszynski JA, Rissmiller BJ, Singleton MN, White BR, Zimmerman JJ, Maddux AB, Pinto NP, Fink EL, Watson RS, Smith M, Ringwood M, Graham RJ, POST-PICU and PICU-COS Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Networks.. Health-related quality of life outcome measures for children surviving critical care: a scoping review. Qual Life Res. 2021 Dec; 30: 3383-3394.

                


                  Relland LM, Hall M, Martin DP, Nateri J, Hanson-Huber L, Beebe A, Samora W, Klamar J, Muszynski J, Tobias JD. Immune Function following Major Spinal Surgery and General Anesthesia. J Pediatr Intensive Care. 2021 Nov; 10: 248-255.

                


                  Leonard JC, Josephson CD, Luther JF, Wisniewski SR, Allen C, Chiusolo F, Davis AL, Finkelstein RA, Fitzgerald JC, Gaines BA, Goobie SM, Hanson SJ, Hewes HA, Johnson LH, McCollum MO, Muszynski JA, Nair AB, Rosenberg RB, Rouse TM, Sikavitsas A, Singleton MN, Steiner ME, Upperman JS, Vogel AM, Wills H, Winkler MK, Spinella PC. Life-Threatening Bleeding in Children: A Prospective Observational Study. Crit Care Med. 2021 Nov 1; 49: 1943-1954.

                


                  Alexander PMA, Muszynski JA. Ongoing Variability in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation Practices-Could Consensus Change the Next Survey Results? Pediatr Crit Care Med. 2021 Jun 1; 22: 581-584.

                


                  Snyder A, Jedreski K, Fitch J, Wijeratne S, Wetzel A, Hensley J, Flowers M, Bline K, Hall MW, Muszynski JA. Transcriptomic Profiles in Children With Septic Shock With or Without Immunoparalysis. Front Immunol. 2021; 12: 733834.

                


                  Juffermans NP, Aubron C, Duranteau J, Vlaar APJ, Kor DJ, Muszynski JA, Spinella PC, Vincent JL. Transfusion in the mechanically ventilated patient. Intensive Care Med. 2020 Dec; 46: 2450-2457.

                


                  Thakkar RK, Devine R, Popelka J, Hensley J, Fabia R, Muszynski JA, Hall MW. Measures of Systemic Innate Immune Function Predict the Risk of Nosocomial Infection in Pediatric Burn Patients. J Burn Care Res. 2020 Oct 31;  

                


                  Bline KE, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Muszynski JA, Ramilo O, Hall MW. Hydrocortisone treatment is associated with a longer duration of MODS in pediatric patients with severe sepsis and immunoparalysis. Crit Care. 2020 Sep 4; 24: 545.

                


                  Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion. 2020 Aug 29;  267659120952982.

                


                  Srouji LS, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Nicol K, Hall MW, Ramilo O, Muszynski JA. Shock Severity Modifies Associations Between RBC Transfusion in the First 48 Hours of Sepsis Onset and the Duration of Organ Dysfunction in Critically Ill Septic Children. Pediatr Crit Care Med. 2020 Aug; 21: e475-e484.

                


                  Wirtz MR, Almizraq RJ, Weber NC, Norris PJ, Pandey S, Spinella PC, Muszynski JA, P Acker J, Juffermans NP. Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation. Vox Sang. 2020 Jul; 115: 395-404.

                


                  Sribnick EA, Hensley J, Moore-Clingenpeel M, Muszynski JA, Thakkar RK, Hall MW. Nosocomial Infection Following Severe Traumatic Injury in Children. Pediatr Crit Care Med. 2020 May; 21: 443-450.

                


                  Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF, ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P.. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019 Dec 10; 322: 2179-2190.

                


                  Menocha S, Muszynski JA. Transfusion-related immune modulation: functional consequence of extracellular vesicles? Transfusion. 2019 Jul 19;  

                


                  Thakkar RK, Weiss SL, Fitzgerald JC, Keele L, Thomas NJ, Nadkarni VM, Muszynski JA, Hall MW, SPROUT Investigators., Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis. J Surg Res. 2019 May 7; 242: 100-110.

                


                  Wirtz MR, Jurgens J, Zuurbier CJ, Roelofs JJTH, Spinella PC, Muszynski JA, Carel Goslings J, Juffermans NP. Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion. Transfusion. 2019 Jan; 59: 134-145.

                


                  Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: 884-898.

                


                  Muszynski JA, Guzzetta NA, Hall MW, Macrae D, Valentine SL, Bateman ST, Spinella PC, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (Blood Net), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: S121-S126.

                


                  Almizraq RJ, Norris PJ, Inglis H, Menocha S, Wirtz MR, Juffermans N, Pandey S, Spinella PC, Acker JP, Muszynski JA. Blood manufacturing methods affect red blood cell product characteristics and immunomodulatory activity. Blood Adv. 2018 Sep 25; 2: 2296-2306.

                


                  Muszynski JA, Nofziger R, Moore-Clingenpeel M, Greathouse K, Anglim L, Steele L, Hensley J, Hanson-Huber L, Nateri J, Ramilo O, Hall MW. Early Immune Function and Duration of Organ Dysfunction in Critically III Children with Sepsis. Am J Respir Crit Care Med. 2018 Aug 1; 198: 361-369.

                


                  Muszynski JA, Reeder RW, Hall MW, Berg RA, Shanley TP, Newth CJL, Pollack MM, Wessel D, Carcillo J, Harrison R, Meert KL, Dean JM, Jenkins T, Tamburro RF, Dalton HJ, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support. Crit Care Med. 2018 Jun; 46: e552-e559.

                


                  Shah S, Coppolino K, Menocha S, Beceiro S, Nateri J, Spinella PC, Nicol K, Hall MW, Muszynski JA, investigators of the PALISI BloodNet network.. Immunomodulatory effects of plasma products on monocyte function in vitro. J Trauma Acute Care Surg. 2018 Jun; 84: S47-S53.

                


                  Remy KE, Hall MW, Cholette J, Juffermans NP, Nicol K, Doctor A, Blumberg N, Spinella PC, Norris PJ, Dahmer MK, Muszynski JA, Pediatric Critical Care Blood Research Network (Blood Net).. Mechanisms of red blood cell transfusion-related immunomodulation. Transfusion. 2018 Mar; 58: 804-815.

                


                  Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. Transfusion. 2018 Jan; 58: 255-266.

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Research

Lab(s)

Center for Clinical and Translational Research

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

View My Publications

Publications

                  Steffen KM, Tucci M, Doctor A, Reeder R, Caro JJ, Muszynski JA, Spinella PC, Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The Impact of Restrictive Transfusion Practices on Hemodynamically Stable Critically Ill Children Without Heart Disease: A Secondary Analysis of the Age of Blood in Children in the PICU Trial. Pediatr Crit Care Med. 2023 Feb 1; 24: 84-92.

                


                  Lovett ME, Daniel M, Keesari R, MacDonald J, Rodriguez V, Muszynski J, Sribnick EA, O'Brien NF, Ayad O. Catheter-associated deep vein thrombosis in children with severe traumatic brain injury: A single-center experience. Pediatr Blood Cancer. 2022 Oct 17;  e30044.

                


                  Russell RT, Esparaz JR, Beckwith MA, Abraham PJ, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper C, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Recommendations. J Trauma Acute Care Surg. 2022 Oct 17;  

                


                  Russell RT, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper CM, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Research Priorities. J Trauma Acute Care Surg. 2022 Oct 7;  

                


                  Bline KE, Muszynski JA, Guess AJ, Menocha S, Moore-Clingenpeel MD, Popelka JK, Hensley JM, Steele LM, Goldthwaite IC, Jedreski KJ, Hall MW. Novel Identification of Myeloid-Derived Suppressor Cells in Children With Septic Shock. Pediatr Crit Care Med. 2022 Sep 8;  

                


                  Johnson H, Raees M, Urbina E, Muszynski J, Seydel K, Taylor T, O'Brien N. Multiple Organ Dysfunction Syndrome and Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Cerebral Malaria. Am J Trop Med Hyg. 2022 Sep 6;  

                


                  Thomas KA, Shea SM, Saini A, Muszynski JA, Spinella PC. Correlation between Thrombin Generation, Standard Coagulation Assays, and Viscoelastic Assays for Hemostatic Assessment in Critically Ill Children. J Appl Lab Med. 2022 May 19;  

                


                  Bailly DK, Reeder RW, Muszynski JA, Meert KL, Ankola AA, Alexander PM, Pollack MM, Moler FW, Berg RA, Carcillo J, Newth C, Berger J, Bell MJ, Dean JM, Nicholson C, Garcia-Filion P, Wessel D, Heidemann S, Doctor A, Harrison R, Dalton H, Zuppa AF. Anticoagulation practices associated with bleeding and thrombosis in pediatric extracorporeal membrane oxygenation; a multi-center secondary analysis. Perfusion. 2022 Feb 27;  2676591211056562.

                


                  Traube C, Tucci M, Nellis ME, Avery KL, McQuillen PS, Fitzgerald JC, Muszynski JA, Cholette JM, Schwarz AJ, Stalets EL, Quaid MA, Hanson SJ, Lacroix J, Reeder RW, Spinella PC, Transfusion-Associated Delirium ABC-PICU Study Group.. Transfusion-Associated Delirium in Children: No Difference Between Short Storage Versus Standard Issue RBCs. Crit Care Med. 2022 Feb 1; 50: 173-182.

                


                  Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB). Pediatr Crit Care Med. 2022 Jan 1; 23: 34-51.

                


                  Cholette JM, Muszynski JA, Ibla JC, Emani S, Steiner ME, Vogel AM, Parker RI, Nellis ME, Bembea MM, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Plasma and Platelet Transfusions Strategies in Neonates and Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass or Neonates and Children Supported by Extracorporeal Membrane Oxygenation: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e25-e36.

                


                  Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e1-e13.

                


                  Muszynski JA, Cholette JM, Steiner ME, Tucci M, Doctor A, Parker RI, Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative.. Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1; 149: S74-S78.

                


                  Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yeyha N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. Pediatrics. 2022 Jan 1; 149: S1-S12.

                


                  Muszynski JA, Banks R, Reeder RW, Hall MW, Berg RA, Zuppa A, Shanley TP, Cornell TT, Newth CJL, Pollack MM, Wessel D, Doctor A, Lin JC, Harrison RE, Meert KL, Dean JM, Holubkov R, Carcillo JA, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. Outcomes Associated With Early RBC Transfusion in Pediatric Severe Sepsis: A Propensity-Adjusted Multicenter Cohort Study. Shock. 2022 Jan 1; 57: 88-94.

                


                  Killien EY, Loftis LL, Clark JD, Muszynski JA, Rissmiller BJ, Singleton MN, White BR, Zimmerman JJ, Maddux AB, Pinto NP, Fink EL, Watson RS, Smith M, Ringwood M, Graham RJ, POST-PICU and PICU-COS Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Networks.. Health-related quality of life outcome measures for children surviving critical care: a scoping review. Qual Life Res. 2021 Dec; 30: 3383-3394.

                


                  Relland LM, Hall M, Martin DP, Nateri J, Hanson-Huber L, Beebe A, Samora W, Klamar J, Muszynski J, Tobias JD. Immune Function following Major Spinal Surgery and General Anesthesia. J Pediatr Intensive Care. 2021 Nov; 10: 248-255.

                


                  Leonard JC, Josephson CD, Luther JF, Wisniewski SR, Allen C, Chiusolo F, Davis AL, Finkelstein RA, Fitzgerald JC, Gaines BA, Goobie SM, Hanson SJ, Hewes HA, Johnson LH, McCollum MO, Muszynski JA, Nair AB, Rosenberg RB, Rouse TM, Sikavitsas A, Singleton MN, Steiner ME, Upperman JS, Vogel AM, Wills H, Winkler MK, Spinella PC. Life-Threatening Bleeding in Children: A Prospective Observational Study. Crit Care Med. 2021 Nov 1; 49: 1943-1954.

                


                  Alexander PMA, Muszynski JA. Ongoing Variability in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation Practices-Could Consensus Change the Next Survey Results? Pediatr Crit Care Med. 2021 Jun 1; 22: 581-584.

                


                  Snyder A, Jedreski K, Fitch J, Wijeratne S, Wetzel A, Hensley J, Flowers M, Bline K, Hall MW, Muszynski JA. Transcriptomic Profiles in Children With Septic Shock With or Without Immunoparalysis. Front Immunol. 2021; 12: 733834.

                


                  Juffermans NP, Aubron C, Duranteau J, Vlaar APJ, Kor DJ, Muszynski JA, Spinella PC, Vincent JL. Transfusion in the mechanically ventilated patient. Intensive Care Med. 2020 Dec; 46: 2450-2457.

                


                  Thakkar RK, Devine R, Popelka J, Hensley J, Fabia R, Muszynski JA, Hall MW. Measures of Systemic Innate Immune Function Predict the Risk of Nosocomial Infection in Pediatric Burn Patients. J Burn Care Res. 2020 Oct 31;  

                


                  Bline KE, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Muszynski JA, Ramilo O, Hall MW. Hydrocortisone treatment is associated with a longer duration of MODS in pediatric patients with severe sepsis and immunoparalysis. Crit Care. 2020 Sep 4; 24: 545.

                


                  Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion. 2020 Aug 29;  267659120952982.

                


                  Srouji LS, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Nicol K, Hall MW, Ramilo O, Muszynski JA. Shock Severity Modifies Associations Between RBC Transfusion in the First 48 Hours of Sepsis Onset and the Duration of Organ Dysfunction in Critically Ill Septic Children. Pediatr Crit Care Med. 2020 Aug; 21: e475-e484.

                


                  Wirtz MR, Almizraq RJ, Weber NC, Norris PJ, Pandey S, Spinella PC, Muszynski JA, P Acker J, Juffermans NP. Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation. Vox Sang. 2020 Jul; 115: 395-404.

                


                  Sribnick EA, Hensley J, Moore-Clingenpeel M, Muszynski JA, Thakkar RK, Hall MW. Nosocomial Infection Following Severe Traumatic Injury in Children. Pediatr Crit Care Med. 2020 May; 21: 443-450.

                


                  Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF, ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P.. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019 Dec 10; 322: 2179-2190.

                


                  Menocha S, Muszynski JA. Transfusion-related immune modulation: functional consequence of extracellular vesicles? Transfusion. 2019 Jul 19;  

                


                  Thakkar RK, Weiss SL, Fitzgerald JC, Keele L, Thomas NJ, Nadkarni VM, Muszynski JA, Hall MW, SPROUT Investigators., Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis. J Surg Res. 2019 May 7; 242: 100-110.

                


                  Wirtz MR, Jurgens J, Zuurbier CJ, Roelofs JJTH, Spinella PC, Muszynski JA, Carel Goslings J, Juffermans NP. Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion. Transfusion. 2019 Jan; 59: 134-145.

                


                  Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: 884-898.

                


                  Muszynski JA, Guzzetta NA, Hall MW, Macrae D, Valentine SL, Bateman ST, Spinella PC, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (Blood Net), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: S121-S126.

                


                  Almizraq RJ, Norris PJ, Inglis H, Menocha S, Wirtz MR, Juffermans N, Pandey S, Spinella PC, Acker JP, Muszynski JA. Blood manufacturing methods affect red blood cell product characteristics and immunomodulatory activity. Blood Adv. 2018 Sep 25; 2: 2296-2306.

                


                  Muszynski JA, Nofziger R, Moore-Clingenpeel M, Greathouse K, Anglim L, Steele L, Hensley J, Hanson-Huber L, Nateri J, Ramilo O, Hall MW. Early Immune Function and Duration of Organ Dysfunction in Critically III Children with Sepsis. Am J Respir Crit Care Med. 2018 Aug 1; 198: 361-369.

                


                  Muszynski JA, Reeder RW, Hall MW, Berg RA, Shanley TP, Newth CJL, Pollack MM, Wessel D, Carcillo J, Harrison R, Meert KL, Dean JM, Jenkins T, Tamburro RF, Dalton HJ, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support. Crit Care Med. 2018 Jun; 46: e552-e559.

                


                  Shah S, Coppolino K, Menocha S, Beceiro S, Nateri J, Spinella PC, Nicol K, Hall MW, Muszynski JA, investigators of the PALISI BloodNet network.. Immunomodulatory effects of plasma products on monocyte function in vitro. J Trauma Acute Care Surg. 2018 Jun; 84: S47-S53.

                


                  Remy KE, Hall MW, Cholette J, Juffermans NP, Nicol K, Doctor A, Blumberg N, Spinella PC, Norris PJ, Dahmer MK, Muszynski JA, Pediatric Critical Care Blood Research Network (Blood Net).. Mechanisms of red blood cell transfusion-related immunomodulation. Transfusion. 2018 Mar; 58: 804-815.

                


                  Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. Transfusion. 2018 Jan; 58: 255-266.

View More Publications

Research

Lab(s)

Center for Clinical and Translational Research

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

View My Publications

Publications

                  Steffen KM, Tucci M, Doctor A, Reeder R, Caro JJ, Muszynski JA, Spinella PC, Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The Impact of Restrictive Transfusion Practices on Hemodynamically Stable Critically Ill Children Without Heart Disease: A Secondary Analysis of the Age of Blood in Children in the PICU Trial. Pediatr Crit Care Med. 2023 Feb 1; 24: 84-92.

                


                  Lovett ME, Daniel M, Keesari R, MacDonald J, Rodriguez V, Muszynski J, Sribnick EA, O'Brien NF, Ayad O. Catheter-associated deep vein thrombosis in children with severe traumatic brain injury: A single-center experience. Pediatr Blood Cancer. 2022 Oct 17;  e30044.

                


                  Russell RT, Esparaz JR, Beckwith MA, Abraham PJ, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper C, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Recommendations. J Trauma Acute Care Surg. 2022 Oct 17;  

                


                  Russell RT, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper CM, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Research Priorities. J Trauma Acute Care Surg. 2022 Oct 7;  

                


                  Bline KE, Muszynski JA, Guess AJ, Menocha S, Moore-Clingenpeel MD, Popelka JK, Hensley JM, Steele LM, Goldthwaite IC, Jedreski KJ, Hall MW. Novel Identification of Myeloid-Derived Suppressor Cells in Children With Septic Shock. Pediatr Crit Care Med. 2022 Sep 8;  

                


                  Johnson H, Raees M, Urbina E, Muszynski J, Seydel K, Taylor T, O'Brien N. Multiple Organ Dysfunction Syndrome and Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Cerebral Malaria. Am J Trop Med Hyg. 2022 Sep 6;  

                


                  Thomas KA, Shea SM, Saini A, Muszynski JA, Spinella PC. Correlation between Thrombin Generation, Standard Coagulation Assays, and Viscoelastic Assays for Hemostatic Assessment in Critically Ill Children. J Appl Lab Med. 2022 May 19;  

                


                  Bailly DK, Reeder RW, Muszynski JA, Meert KL, Ankola AA, Alexander PM, Pollack MM, Moler FW, Berg RA, Carcillo J, Newth C, Berger J, Bell MJ, Dean JM, Nicholson C, Garcia-Filion P, Wessel D, Heidemann S, Doctor A, Harrison R, Dalton H, Zuppa AF. Anticoagulation practices associated with bleeding and thrombosis in pediatric extracorporeal membrane oxygenation; a multi-center secondary analysis. Perfusion. 2022 Feb 27;  2676591211056562.

                


                  Traube C, Tucci M, Nellis ME, Avery KL, McQuillen PS, Fitzgerald JC, Muszynski JA, Cholette JM, Schwarz AJ, Stalets EL, Quaid MA, Hanson SJ, Lacroix J, Reeder RW, Spinella PC, Transfusion-Associated Delirium ABC-PICU Study Group.. Transfusion-Associated Delirium in Children: No Difference Between Short Storage Versus Standard Issue RBCs. Crit Care Med. 2022 Feb 1; 50: 173-182.

                


                  Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB). Pediatr Crit Care Med. 2022 Jan 1; 23: 34-51.

                


                  Cholette JM, Muszynski JA, Ibla JC, Emani S, Steiner ME, Vogel AM, Parker RI, Nellis ME, Bembea MM, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Plasma and Platelet Transfusions Strategies in Neonates and Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass or Neonates and Children Supported by Extracorporeal Membrane Oxygenation: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e25-e36.

                


                  Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e1-e13.

                


                  Muszynski JA, Cholette JM, Steiner ME, Tucci M, Doctor A, Parker RI, Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative.. Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1; 149: S74-S78.

                


                  Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yeyha N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. Pediatrics. 2022 Jan 1; 149: S1-S12.

                


                  Muszynski JA, Banks R, Reeder RW, Hall MW, Berg RA, Zuppa A, Shanley TP, Cornell TT, Newth CJL, Pollack MM, Wessel D, Doctor A, Lin JC, Harrison RE, Meert KL, Dean JM, Holubkov R, Carcillo JA, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. Outcomes Associated With Early RBC Transfusion in Pediatric Severe Sepsis: A Propensity-Adjusted Multicenter Cohort Study. Shock. 2022 Jan 1; 57: 88-94.

                


                  Killien EY, Loftis LL, Clark JD, Muszynski JA, Rissmiller BJ, Singleton MN, White BR, Zimmerman JJ, Maddux AB, Pinto NP, Fink EL, Watson RS, Smith M, Ringwood M, Graham RJ, POST-PICU and PICU-COS Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Networks.. Health-related quality of life outcome measures for children surviving critical care: a scoping review. Qual Life Res. 2021 Dec; 30: 3383-3394.

                


                  Relland LM, Hall M, Martin DP, Nateri J, Hanson-Huber L, Beebe A, Samora W, Klamar J, Muszynski J, Tobias JD. Immune Function following Major Spinal Surgery and General Anesthesia. J Pediatr Intensive Care. 2021 Nov; 10: 248-255.

                


                  Leonard JC, Josephson CD, Luther JF, Wisniewski SR, Allen C, Chiusolo F, Davis AL, Finkelstein RA, Fitzgerald JC, Gaines BA, Goobie SM, Hanson SJ, Hewes HA, Johnson LH, McCollum MO, Muszynski JA, Nair AB, Rosenberg RB, Rouse TM, Sikavitsas A, Singleton MN, Steiner ME, Upperman JS, Vogel AM, Wills H, Winkler MK, Spinella PC. Life-Threatening Bleeding in Children: A Prospective Observational Study. Crit Care Med. 2021 Nov 1; 49: 1943-1954.

                


                  Alexander PMA, Muszynski JA. Ongoing Variability in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation Practices-Could Consensus Change the Next Survey Results? Pediatr Crit Care Med. 2021 Jun 1; 22: 581-584.

                


                  Snyder A, Jedreski K, Fitch J, Wijeratne S, Wetzel A, Hensley J, Flowers M, Bline K, Hall MW, Muszynski JA. Transcriptomic Profiles in Children With Septic Shock With or Without Immunoparalysis. Front Immunol. 2021; 12: 733834.

                


                  Juffermans NP, Aubron C, Duranteau J, Vlaar APJ, Kor DJ, Muszynski JA, Spinella PC, Vincent JL. Transfusion in the mechanically ventilated patient. Intensive Care Med. 2020 Dec; 46: 2450-2457.

                


                  Thakkar RK, Devine R, Popelka J, Hensley J, Fabia R, Muszynski JA, Hall MW. Measures of Systemic Innate Immune Function Predict the Risk of Nosocomial Infection in Pediatric Burn Patients. J Burn Care Res. 2020 Oct 31;  

                


                  Bline KE, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Muszynski JA, Ramilo O, Hall MW. Hydrocortisone treatment is associated with a longer duration of MODS in pediatric patients with severe sepsis and immunoparalysis. Crit Care. 2020 Sep 4; 24: 545.

                


                  Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion. 2020 Aug 29;  267659120952982.

                


                  Srouji LS, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Nicol K, Hall MW, Ramilo O, Muszynski JA. Shock Severity Modifies Associations Between RBC Transfusion in the First 48 Hours of Sepsis Onset and the Duration of Organ Dysfunction in Critically Ill Septic Children. Pediatr Crit Care Med. 2020 Aug; 21: e475-e484.

                


                  Wirtz MR, Almizraq RJ, Weber NC, Norris PJ, Pandey S, Spinella PC, Muszynski JA, P Acker J, Juffermans NP. Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation. Vox Sang. 2020 Jul; 115: 395-404.

                


                  Sribnick EA, Hensley J, Moore-Clingenpeel M, Muszynski JA, Thakkar RK, Hall MW. Nosocomial Infection Following Severe Traumatic Injury in Children. Pediatr Crit Care Med. 2020 May; 21: 443-450.

                


                  Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF, ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P.. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019 Dec 10; 322: 2179-2190.

                


                  Menocha S, Muszynski JA. Transfusion-related immune modulation: functional consequence of extracellular vesicles? Transfusion. 2019 Jul 19;  

                


                  Thakkar RK, Weiss SL, Fitzgerald JC, Keele L, Thomas NJ, Nadkarni VM, Muszynski JA, Hall MW, SPROUT Investigators., Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis. J Surg Res. 2019 May 7; 242: 100-110.

                


                  Wirtz MR, Jurgens J, Zuurbier CJ, Roelofs JJTH, Spinella PC, Muszynski JA, Carel Goslings J, Juffermans NP. Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion. Transfusion. 2019 Jan; 59: 134-145.

                


                  Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: 884-898.

                


                  Muszynski JA, Guzzetta NA, Hall MW, Macrae D, Valentine SL, Bateman ST, Spinella PC, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (Blood Net), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: S121-S126.

                


                  Almizraq RJ, Norris PJ, Inglis H, Menocha S, Wirtz MR, Juffermans N, Pandey S, Spinella PC, Acker JP, Muszynski JA. Blood manufacturing methods affect red blood cell product characteristics and immunomodulatory activity. Blood Adv. 2018 Sep 25; 2: 2296-2306.

                


                  Muszynski JA, Nofziger R, Moore-Clingenpeel M, Greathouse K, Anglim L, Steele L, Hensley J, Hanson-Huber L, Nateri J, Ramilo O, Hall MW. Early Immune Function and Duration of Organ Dysfunction in Critically III Children with Sepsis. Am J Respir Crit Care Med. 2018 Aug 1; 198: 361-369.

                


                  Muszynski JA, Reeder RW, Hall MW, Berg RA, Shanley TP, Newth CJL, Pollack MM, Wessel D, Carcillo J, Harrison R, Meert KL, Dean JM, Jenkins T, Tamburro RF, Dalton HJ, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support. Crit Care Med. 2018 Jun; 46: e552-e559.

                


                  Shah S, Coppolino K, Menocha S, Beceiro S, Nateri J, Spinella PC, Nicol K, Hall MW, Muszynski JA, investigators of the PALISI BloodNet network.. Immunomodulatory effects of plasma products on monocyte function in vitro. J Trauma Acute Care Surg. 2018 Jun; 84: S47-S53.

                


                  Remy KE, Hall MW, Cholette J, Juffermans NP, Nicol K, Doctor A, Blumberg N, Spinella PC, Norris PJ, Dahmer MK, Muszynski JA, Pediatric Critical Care Blood Research Network (Blood Net).. Mechanisms of red blood cell transfusion-related immunomodulation. Transfusion. 2018 Mar; 58: 804-815.

                


                  Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. Transfusion. 2018 Jan; 58: 255-266.

View More Publications

Lab(s)

Center for Clinical and Translational Research

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

View My Publications

Publications

                  Steffen KM, Tucci M, Doctor A, Reeder R, Caro JJ, Muszynski JA, Spinella PC, Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The Impact of Restrictive Transfusion Practices on Hemodynamically Stable Critically Ill Children Without Heart Disease: A Secondary Analysis of the Age of Blood in Children in the PICU Trial. Pediatr Crit Care Med. 2023 Feb 1; 24: 84-92.

                


                  Lovett ME, Daniel M, Keesari R, MacDonald J, Rodriguez V, Muszynski J, Sribnick EA, O'Brien NF, Ayad O. Catheter-associated deep vein thrombosis in children with severe traumatic brain injury: A single-center experience. Pediatr Blood Cancer. 2022 Oct 17;  e30044.

                


                  Russell RT, Esparaz JR, Beckwith MA, Abraham PJ, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper C, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Recommendations. J Trauma Acute Care Surg. 2022 Oct 17;  

                


                  Russell RT, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper CM, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Research Priorities. J Trauma Acute Care Surg. 2022 Oct 7;  

                


                  Bline KE, Muszynski JA, Guess AJ, Menocha S, Moore-Clingenpeel MD, Popelka JK, Hensley JM, Steele LM, Goldthwaite IC, Jedreski KJ, Hall MW. Novel Identification of Myeloid-Derived Suppressor Cells in Children With Septic Shock. Pediatr Crit Care Med. 2022 Sep 8;  

                


                  Johnson H, Raees M, Urbina E, Muszynski J, Seydel K, Taylor T, O'Brien N. Multiple Organ Dysfunction Syndrome and Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Cerebral Malaria. Am J Trop Med Hyg. 2022 Sep 6;  

                


                  Thomas KA, Shea SM, Saini A, Muszynski JA, Spinella PC. Correlation between Thrombin Generation, Standard Coagulation Assays, and Viscoelastic Assays for Hemostatic Assessment in Critically Ill Children. J Appl Lab Med. 2022 May 19;  

                


                  Bailly DK, Reeder RW, Muszynski JA, Meert KL, Ankola AA, Alexander PM, Pollack MM, Moler FW, Berg RA, Carcillo J, Newth C, Berger J, Bell MJ, Dean JM, Nicholson C, Garcia-Filion P, Wessel D, Heidemann S, Doctor A, Harrison R, Dalton H, Zuppa AF. Anticoagulation practices associated with bleeding and thrombosis in pediatric extracorporeal membrane oxygenation; a multi-center secondary analysis. Perfusion. 2022 Feb 27;  2676591211056562.

                


                  Traube C, Tucci M, Nellis ME, Avery KL, McQuillen PS, Fitzgerald JC, Muszynski JA, Cholette JM, Schwarz AJ, Stalets EL, Quaid MA, Hanson SJ, Lacroix J, Reeder RW, Spinella PC, Transfusion-Associated Delirium ABC-PICU Study Group.. Transfusion-Associated Delirium in Children: No Difference Between Short Storage Versus Standard Issue RBCs. Crit Care Med. 2022 Feb 1; 50: 173-182.

                


                  Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB). Pediatr Crit Care Med. 2022 Jan 1; 23: 34-51.

                


                  Cholette JM, Muszynski JA, Ibla JC, Emani S, Steiner ME, Vogel AM, Parker RI, Nellis ME, Bembea MM, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Plasma and Platelet Transfusions Strategies in Neonates and Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass or Neonates and Children Supported by Extracorporeal Membrane Oxygenation: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e25-e36.

                


                  Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e1-e13.

                


                  Muszynski JA, Cholette JM, Steiner ME, Tucci M, Doctor A, Parker RI, Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative.. Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1; 149: S74-S78.

                


                  Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yeyha N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. Pediatrics. 2022 Jan 1; 149: S1-S12.

                


                  Muszynski JA, Banks R, Reeder RW, Hall MW, Berg RA, Zuppa A, Shanley TP, Cornell TT, Newth CJL, Pollack MM, Wessel D, Doctor A, Lin JC, Harrison RE, Meert KL, Dean JM, Holubkov R, Carcillo JA, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. Outcomes Associated With Early RBC Transfusion in Pediatric Severe Sepsis: A Propensity-Adjusted Multicenter Cohort Study. Shock. 2022 Jan 1; 57: 88-94.

                


                  Killien EY, Loftis LL, Clark JD, Muszynski JA, Rissmiller BJ, Singleton MN, White BR, Zimmerman JJ, Maddux AB, Pinto NP, Fink EL, Watson RS, Smith M, Ringwood M, Graham RJ, POST-PICU and PICU-COS Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Networks.. Health-related quality of life outcome measures for children surviving critical care: a scoping review. Qual Life Res. 2021 Dec; 30: 3383-3394.

                


                  Relland LM, Hall M, Martin DP, Nateri J, Hanson-Huber L, Beebe A, Samora W, Klamar J, Muszynski J, Tobias JD. Immune Function following Major Spinal Surgery and General Anesthesia. J Pediatr Intensive Care. 2021 Nov; 10: 248-255.

                


                  Leonard JC, Josephson CD, Luther JF, Wisniewski SR, Allen C, Chiusolo F, Davis AL, Finkelstein RA, Fitzgerald JC, Gaines BA, Goobie SM, Hanson SJ, Hewes HA, Johnson LH, McCollum MO, Muszynski JA, Nair AB, Rosenberg RB, Rouse TM, Sikavitsas A, Singleton MN, Steiner ME, Upperman JS, Vogel AM, Wills H, Winkler MK, Spinella PC. Life-Threatening Bleeding in Children: A Prospective Observational Study. Crit Care Med. 2021 Nov 1; 49: 1943-1954.

                


                  Alexander PMA, Muszynski JA. Ongoing Variability in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation Practices-Could Consensus Change the Next Survey Results? Pediatr Crit Care Med. 2021 Jun 1; 22: 581-584.

                


                  Snyder A, Jedreski K, Fitch J, Wijeratne S, Wetzel A, Hensley J, Flowers M, Bline K, Hall MW, Muszynski JA. Transcriptomic Profiles in Children With Septic Shock With or Without Immunoparalysis. Front Immunol. 2021; 12: 733834.

                


                  Juffermans NP, Aubron C, Duranteau J, Vlaar APJ, Kor DJ, Muszynski JA, Spinella PC, Vincent JL. Transfusion in the mechanically ventilated patient. Intensive Care Med. 2020 Dec; 46: 2450-2457.

                


                  Thakkar RK, Devine R, Popelka J, Hensley J, Fabia R, Muszynski JA, Hall MW. Measures of Systemic Innate Immune Function Predict the Risk of Nosocomial Infection in Pediatric Burn Patients. J Burn Care Res. 2020 Oct 31;  

                


                  Bline KE, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Muszynski JA, Ramilo O, Hall MW. Hydrocortisone treatment is associated with a longer duration of MODS in pediatric patients with severe sepsis and immunoparalysis. Crit Care. 2020 Sep 4; 24: 545.

                


                  Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion. 2020 Aug 29;  267659120952982.

                


                  Srouji LS, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Nicol K, Hall MW, Ramilo O, Muszynski JA. Shock Severity Modifies Associations Between RBC Transfusion in the First 48 Hours of Sepsis Onset and the Duration of Organ Dysfunction in Critically Ill Septic Children. Pediatr Crit Care Med. 2020 Aug; 21: e475-e484.

                


                  Wirtz MR, Almizraq RJ, Weber NC, Norris PJ, Pandey S, Spinella PC, Muszynski JA, P Acker J, Juffermans NP. Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation. Vox Sang. 2020 Jul; 115: 395-404.

                


                  Sribnick EA, Hensley J, Moore-Clingenpeel M, Muszynski JA, Thakkar RK, Hall MW. Nosocomial Infection Following Severe Traumatic Injury in Children. Pediatr Crit Care Med. 2020 May; 21: 443-450.

                


                  Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF, ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P.. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019 Dec 10; 322: 2179-2190.

                


                  Menocha S, Muszynski JA. Transfusion-related immune modulation: functional consequence of extracellular vesicles? Transfusion. 2019 Jul 19;  

                


                  Thakkar RK, Weiss SL, Fitzgerald JC, Keele L, Thomas NJ, Nadkarni VM, Muszynski JA, Hall MW, SPROUT Investigators., Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis. J Surg Res. 2019 May 7; 242: 100-110.

                


                  Wirtz MR, Jurgens J, Zuurbier CJ, Roelofs JJTH, Spinella PC, Muszynski JA, Carel Goslings J, Juffermans NP. Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion. Transfusion. 2019 Jan; 59: 134-145.

                


                  Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: 884-898.

                


                  Muszynski JA, Guzzetta NA, Hall MW, Macrae D, Valentine SL, Bateman ST, Spinella PC, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (Blood Net), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: S121-S126.

                


                  Almizraq RJ, Norris PJ, Inglis H, Menocha S, Wirtz MR, Juffermans N, Pandey S, Spinella PC, Acker JP, Muszynski JA. Blood manufacturing methods affect red blood cell product characteristics and immunomodulatory activity. Blood Adv. 2018 Sep 25; 2: 2296-2306.

                


                  Muszynski JA, Nofziger R, Moore-Clingenpeel M, Greathouse K, Anglim L, Steele L, Hensley J, Hanson-Huber L, Nateri J, Ramilo O, Hall MW. Early Immune Function and Duration of Organ Dysfunction in Critically III Children with Sepsis. Am J Respir Crit Care Med. 2018 Aug 1; 198: 361-369.

                


                  Muszynski JA, Reeder RW, Hall MW, Berg RA, Shanley TP, Newth CJL, Pollack MM, Wessel D, Carcillo J, Harrison R, Meert KL, Dean JM, Jenkins T, Tamburro RF, Dalton HJ, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support. Crit Care Med. 2018 Jun; 46: e552-e559.

                


                  Shah S, Coppolino K, Menocha S, Beceiro S, Nateri J, Spinella PC, Nicol K, Hall MW, Muszynski JA, investigators of the PALISI BloodNet network.. Immunomodulatory effects of plasma products on monocyte function in vitro. J Trauma Acute Care Surg. 2018 Jun; 84: S47-S53.

                


                  Remy KE, Hall MW, Cholette J, Juffermans NP, Nicol K, Doctor A, Blumberg N, Spinella PC, Norris PJ, Dahmer MK, Muszynski JA, Pediatric Critical Care Blood Research Network (Blood Net).. Mechanisms of red blood cell transfusion-related immunomodulation. Transfusion. 2018 Mar; 58: 804-815.

                


                  Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. Transfusion. 2018 Jan; 58: 255-266.

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Lab(s)

Center for Clinical and Translational Research

Dr. Muszynski’s primary area of research focuses on the immunobiology of pediatric critical illness and effects of blood product transfusion. She is the Chair of the Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) research network. Her ongoing clinical and translational studies are aimed at dissecting complex interactions between host immune cell function, inflammation, blood product transfusion, and clinical outcomes in children with sepsis, trauma, acute lung injury and multiple organ dysfunction.

Lab(s)

Center for Clinical and Translational Research

• Center for Clinical and Translational Research

• View My Publications

                  Steffen KM, Tucci M, Doctor A, Reeder R, Caro JJ, Muszynski JA, Spinella PC, Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The Impact of Restrictive Transfusion Practices on Hemodynamically Stable Critically Ill Children Without Heart Disease: A Secondary Analysis of the Age of Blood in Children in the PICU Trial. Pediatr Crit Care Med. 2023 Feb 1; 24: 84-92.
  
  
  
                  Lovett ME, Daniel M, Keesari R, MacDonald J, Rodriguez V, Muszynski J, Sribnick EA, O'Brien NF, Ayad O. Catheter-associated deep vein thrombosis in children with severe traumatic brain injury: A single-center experience. Pediatr Blood Cancer. 2022 Oct 17;  e30044.
  
  
  
                  Russell RT, Esparaz JR, Beckwith MA, Abraham PJ, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper C, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Recommendations. J Trauma Acute Care Surg. 2022 Oct 17;  
  
  
  
                  Russell RT, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper CM, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Research Priorities. J Trauma Acute Care Surg. 2022 Oct 7;  
  
  
  
                  Bline KE, Muszynski JA, Guess AJ, Menocha S, Moore-Clingenpeel MD, Popelka JK, Hensley JM, Steele LM, Goldthwaite IC, Jedreski KJ, Hall MW. Novel Identification of Myeloid-Derived Suppressor Cells in Children With Septic Shock. Pediatr Crit Care Med. 2022 Sep 8;  
  
  
  
                  Johnson H, Raees M, Urbina E, Muszynski J, Seydel K, Taylor T, O'Brien N. Multiple Organ Dysfunction Syndrome and Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Cerebral Malaria. Am J Trop Med Hyg. 2022 Sep 6;  
  
  
  
                  Thomas KA, Shea SM, Saini A, Muszynski JA, Spinella PC. Correlation between Thrombin Generation, Standard Coagulation Assays, and Viscoelastic Assays for Hemostatic Assessment in Critically Ill Children. J Appl Lab Med. 2022 May 19;  
  
  
  
                  Bailly DK, Reeder RW, Muszynski JA, Meert KL, Ankola AA, Alexander PM, Pollack MM, Moler FW, Berg RA, Carcillo J, Newth C, Berger J, Bell MJ, Dean JM, Nicholson C, Garcia-Filion P, Wessel D, Heidemann S, Doctor A, Harrison R, Dalton H, Zuppa AF. Anticoagulation practices associated with bleeding and thrombosis in pediatric extracorporeal membrane oxygenation; a multi-center secondary analysis. Perfusion. 2022 Feb 27;  2676591211056562.
  
  
  
                  Traube C, Tucci M, Nellis ME, Avery KL, McQuillen PS, Fitzgerald JC, Muszynski JA, Cholette JM, Schwarz AJ, Stalets EL, Quaid MA, Hanson SJ, Lacroix J, Reeder RW, Spinella PC, Transfusion-Associated Delirium ABC-PICU Study Group.. Transfusion-Associated Delirium in Children: No Difference Between Short Storage Versus Standard Issue RBCs. Crit Care Med. 2022 Feb 1; 50: 173-182.
  
  
  
                  Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB). Pediatr Crit Care Med. 2022 Jan 1; 23: 34-51.
  
  
  
                  Cholette JM, Muszynski JA, Ibla JC, Emani S, Steiner ME, Vogel AM, Parker RI, Nellis ME, Bembea MM, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Plasma and Platelet Transfusions Strategies in Neonates and Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass or Neonates and Children Supported by Extracorporeal Membrane Oxygenation: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e25-e36.
  
  
  
                  Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e1-e13.
  
  
  
                  Muszynski JA, Cholette JM, Steiner ME, Tucci M, Doctor A, Parker RI, Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative.. Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1; 149: S74-S78.
  
  
  
                  Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yeyha N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. Pediatrics. 2022 Jan 1; 149: S1-S12.
  
  
  
                  Muszynski JA, Banks R, Reeder RW, Hall MW, Berg RA, Zuppa A, Shanley TP, Cornell TT, Newth CJL, Pollack MM, Wessel D, Doctor A, Lin JC, Harrison RE, Meert KL, Dean JM, Holubkov R, Carcillo JA, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. Outcomes Associated With Early RBC Transfusion in Pediatric Severe Sepsis: A Propensity-Adjusted Multicenter Cohort Study. Shock. 2022 Jan 1; 57: 88-94.
  
  
  
                  Killien EY, Loftis LL, Clark JD, Muszynski JA, Rissmiller BJ, Singleton MN, White BR, Zimmerman JJ, Maddux AB, Pinto NP, Fink EL, Watson RS, Smith M, Ringwood M, Graham RJ, POST-PICU and PICU-COS Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Networks.. Health-related quality of life outcome measures for children surviving critical care: a scoping review. Qual Life Res. 2021 Dec; 30: 3383-3394.
  
  
  
                  Relland LM, Hall M, Martin DP, Nateri J, Hanson-Huber L, Beebe A, Samora W, Klamar J, Muszynski J, Tobias JD. Immune Function following Major Spinal Surgery and General Anesthesia. J Pediatr Intensive Care. 2021 Nov; 10: 248-255.
  
  
  
                  Leonard JC, Josephson CD, Luther JF, Wisniewski SR, Allen C, Chiusolo F, Davis AL, Finkelstein RA, Fitzgerald JC, Gaines BA, Goobie SM, Hanson SJ, Hewes HA, Johnson LH, McCollum MO, Muszynski JA, Nair AB, Rosenberg RB, Rouse TM, Sikavitsas A, Singleton MN, Steiner ME, Upperman JS, Vogel AM, Wills H, Winkler MK, Spinella PC. Life-Threatening Bleeding in Children: A Prospective Observational Study. Crit Care Med. 2021 Nov 1; 49: 1943-1954.
  
  
  
                  Alexander PMA, Muszynski JA. Ongoing Variability in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation Practices-Could Consensus Change the Next Survey Results? Pediatr Crit Care Med. 2021 Jun 1; 22: 581-584.
  
  
  
                  Snyder A, Jedreski K, Fitch J, Wijeratne S, Wetzel A, Hensley J, Flowers M, Bline K, Hall MW, Muszynski JA. Transcriptomic Profiles in Children With Septic Shock With or Without Immunoparalysis. Front Immunol. 2021; 12: 733834.
  
  
  
                  Juffermans NP, Aubron C, Duranteau J, Vlaar APJ, Kor DJ, Muszynski JA, Spinella PC, Vincent JL. Transfusion in the mechanically ventilated patient. Intensive Care Med. 2020 Dec; 46: 2450-2457.
  
  
  
                  Thakkar RK, Devine R, Popelka J, Hensley J, Fabia R, Muszynski JA, Hall MW. Measures of Systemic Innate Immune Function Predict the Risk of Nosocomial Infection in Pediatric Burn Patients. J Burn Care Res. 2020 Oct 31;  
  
  
  
                  Bline KE, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Muszynski JA, Ramilo O, Hall MW. Hydrocortisone treatment is associated with a longer duration of MODS in pediatric patients with severe sepsis and immunoparalysis. Crit Care. 2020 Sep 4; 24: 545.
  
  
  
                  Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion. 2020 Aug 29;  267659120952982.
  
  
  
                  Srouji LS, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Nicol K, Hall MW, Ramilo O, Muszynski JA. Shock Severity Modifies Associations Between RBC Transfusion in the First 48 Hours of Sepsis Onset and the Duration of Organ Dysfunction in Critically Ill Septic Children. Pediatr Crit Care Med. 2020 Aug; 21: e475-e484.
  
  
  
                  Wirtz MR, Almizraq RJ, Weber NC, Norris PJ, Pandey S, Spinella PC, Muszynski JA, P Acker J, Juffermans NP. Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation. Vox Sang. 2020 Jul; 115: 395-404.
  
  
  
                  Sribnick EA, Hensley J, Moore-Clingenpeel M, Muszynski JA, Thakkar RK, Hall MW. Nosocomial Infection Following Severe Traumatic Injury in Children. Pediatr Crit Care Med. 2020 May; 21: 443-450.
  
  
  
                  Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF, ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P.. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019 Dec 10; 322: 2179-2190.
  
  
  
                  Menocha S, Muszynski JA. Transfusion-related immune modulation: functional consequence of extracellular vesicles? Transfusion. 2019 Jul 19;  
  
  
  
                  Thakkar RK, Weiss SL, Fitzgerald JC, Keele L, Thomas NJ, Nadkarni VM, Muszynski JA, Hall MW, SPROUT Investigators., Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis. J Surg Res. 2019 May 7; 242: 100-110.
  
  
  
                  Wirtz MR, Jurgens J, Zuurbier CJ, Roelofs JJTH, Spinella PC, Muszynski JA, Carel Goslings J, Juffermans NP. Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion. Transfusion. 2019 Jan; 59: 134-145.
  
  
  
                  Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: 884-898.
  
  
  
                  Muszynski JA, Guzzetta NA, Hall MW, Macrae D, Valentine SL, Bateman ST, Spinella PC, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (Blood Net), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: S121-S126.
  
  
  
                  Almizraq RJ, Norris PJ, Inglis H, Menocha S, Wirtz MR, Juffermans N, Pandey S, Spinella PC, Acker JP, Muszynski JA. Blood manufacturing methods affect red blood cell product characteristics and immunomodulatory activity. Blood Adv. 2018 Sep 25; 2: 2296-2306.
  
  
  
                  Muszynski JA, Nofziger R, Moore-Clingenpeel M, Greathouse K, Anglim L, Steele L, Hensley J, Hanson-Huber L, Nateri J, Ramilo O, Hall MW. Early Immune Function and Duration of Organ Dysfunction in Critically III Children with Sepsis. Am J Respir Crit Care Med. 2018 Aug 1; 198: 361-369.
  
  
  
                  Muszynski JA, Reeder RW, Hall MW, Berg RA, Shanley TP, Newth CJL, Pollack MM, Wessel D, Carcillo J, Harrison R, Meert KL, Dean JM, Jenkins T, Tamburro RF, Dalton HJ, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support. Crit Care Med. 2018 Jun; 46: e552-e559.
  
  
  
                  Shah S, Coppolino K, Menocha S, Beceiro S, Nateri J, Spinella PC, Nicol K, Hall MW, Muszynski JA, investigators of the PALISI BloodNet network.. Immunomodulatory effects of plasma products on monocyte function in vitro. J Trauma Acute Care Surg. 2018 Jun; 84: S47-S53.
  
  
  
                  Remy KE, Hall MW, Cholette J, Juffermans NP, Nicol K, Doctor A, Blumberg N, Spinella PC, Norris PJ, Dahmer MK, Muszynski JA, Pediatric Critical Care Blood Research Network (Blood Net).. Mechanisms of red blood cell transfusion-related immunomodulation. Transfusion. 2018 Mar; 58: 804-815.
  
  
  
                  Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D'Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016. Transfusion. 2018 Jan; 58: 255-266.
  
  

View More Publications

• Steffen KM, Tucci M, Doctor A, Reeder R, Caro JJ, Muszynski JA, Spinella PC, Pediatric Critical Care Blood Research Network (BloodNet) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The Impact of Restrictive Transfusion Practices on Hemodynamically Stable Critically Ill Children Without Heart Disease: A Secondary Analysis of the Age of Blood in Children in the PICU Trial. Pediatr Crit Care Med. 2023 Feb 1; 24: 84-92.
• Lovett ME, Daniel M, Keesari R, MacDonald J, Rodriguez V, Muszynski J, Sribnick EA, O’Brien NF, Ayad O. Catheter-associated deep vein thrombosis in children with severe traumatic brain injury: A single-center experience. Pediatr Blood Cancer. 2022 Oct 17; e30044.
• Russell RT, Esparaz JR, Beckwith MA, Abraham PJ, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper C, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Recommendations. J Trauma Acute Care Surg. 2022 Oct 17;
• Russell RT, Bembea MM, Borgman MA, Burd RS, Gaines BA, Jafri M, Josephson CD, Leeper CM, Leonard JC, Muszynski JA, Nicol KK, Nishijima DK, Stricker PA, Vogel AM, Wong TE, Spinella PC. Pediatric Traumatic Hemorrhagic Shock Consensus Conference Research Priorities. J Trauma Acute Care Surg. 2022 Oct 7;
• Bline KE, Muszynski JA, Guess AJ, Menocha S, Moore-Clingenpeel MD, Popelka JK, Hensley JM, Steele LM, Goldthwaite IC, Jedreski KJ, Hall MW. Novel Identification of Myeloid-Derived Suppressor Cells in Children With Septic Shock. Pediatr Crit Care Med. 2022 Sep 8;
• Johnson H, Raees M, Urbina E, Muszynski J, Seydel K, Taylor T, O’Brien N. Multiple Organ Dysfunction Syndrome and Pediatric Logistic Organ Dysfunction-2 Score in Pediatric Cerebral Malaria. Am J Trop Med Hyg. 2022 Sep 6;
• Thomas KA, Shea SM, Saini A, Muszynski JA, Spinella PC. Correlation between Thrombin Generation, Standard Coagulation Assays, and Viscoelastic Assays for Hemostatic Assessment in Critically Ill Children. J Appl Lab Med. 2022 May 19;
• Bailly DK, Reeder RW, Muszynski JA, Meert KL, Ankola AA, Alexander PM, Pollack MM, Moler FW, Berg RA, Carcillo J, Newth C, Berger J, Bell MJ, Dean JM, Nicholson C, Garcia-Filion P, Wessel D, Heidemann S, Doctor A, Harrison R, Dalton H, Zuppa AF. Anticoagulation practices associated with bleeding and thrombosis in pediatric extracorporeal membrane oxygenation; a multi-center secondary analysis. Perfusion. 2022 Feb 27; 2676591211056562.
• Traube C, Tucci M, Nellis ME, Avery KL, McQuillen PS, Fitzgerald JC, Muszynski JA, Cholette JM, Schwarz AJ, Stalets EL, Quaid MA, Hanson SJ, Lacroix J, Reeder RW, Spinella PC, Transfusion-Associated Delirium ABC-PICU Study Group.. Transfusion-Associated Delirium in Children: No Difference Between Short Storage Versus Standard Issue RBCs. Crit Care Med. 2022 Feb 1; 50: 173-182.
• Nellis ME, Karam O, Valentine SL, Bateman ST, Remy KE, Lacroix J, Cholette JM, Bembea MM, Russell RT, Steiner ME, Goobie SM, Tucci M, Stricker PA, Stanworth SJ, Delaney M, Lieberman L, Muszynski JA, Bauer DF, Steffen K, Nishijima D, Ibla J, Emani S, Vogel AM, Haas T, Goel R, Crighton G, Delgado D, Demetres M, Parker RI, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB). Pediatr Crit Care Med. 2022 Jan 1; 23: 34-51.
• Cholette JM, Muszynski JA, Ibla JC, Emani S, Steiner ME, Vogel AM, Parker RI, Nellis ME, Bembea MM, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Plasma and Platelet Transfusions Strategies in Neonates and Children Undergoing Cardiac Surgery With Cardiopulmonary Bypass or Neonates and Children Supported by Extracorporeal Membrane Oxygenation: From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e25-e36.
• Delaney M, Karam O, Lieberman L, Steffen K, Muszynski JA, Goel R, Bateman ST, Parker RI, Nellis ME, Remy KE, Pediatric Critical Care Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding (TAXI-CAB), in collaboration with the Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. What Laboratory Tests and Physiologic Triggers Should Guide the Decision to Administer a Platelet or Plasma Transfusion in Critically Ill Children and What Product Attributes Are Optimal to Guide Specific Product Selection? From the Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding. Pediatr Crit Care Med. 2022 Jan 1; 23: e1-e13.
• Muszynski JA, Cholette JM, Steiner ME, Tucci M, Doctor A, Parker RI, Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative.. Hematologic Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference. Pediatrics. 2022 Jan 1; 149: S74-S78.
• Bembea MM, Agus M, Akcan-Arikan A, Alexander P, Basu R, Bennett TD, Bohn D, Brandão LR, Brown AM, Carcillo JA, Checchia P, Cholette J, Cheifetz IM, Cornell T, Doctor A, Eckerle M, Erickson S, Farris RWD, Faustino EVS, Fitzgerald JC, Fuhrman DY, Giuliano JS, Guilliams K, Gaies M, Gorga SM, Hall M, Hanson SJ, Hartman M, Hassinger AB, Irving SY, Jeffries H, Jouvet P, Kannan S, Karam O, Khemani RG, Kissoon N, Lacroix J, Laussen P, Leclerc F, Lee JH, Leteurtre S, Lobner K, McKiernan PJ, Menon K, Monagle P, Muszynski JA, Odetola F, Parker R, Pathan N, Pierce RW, Pineda J, Prince JM, Robinson KA, Rowan CM, Ryerson LM, Sanchez-Pinto LN, Schlapbach LJ, Selewski DT, Shekerdemian LS, Simon D, Smith LS, Squires JE, Squires RH, Sutherland SM, Ouellette Y, Spaeder MC, Srinivasan V, Steiner ME, Tasker RC, Thiagarajan R, Thomas N, Tissieres P, Traube C, Tucci M, Typpo KV, Wainwright MS, Ward SL, Watson RS, Weiss S, Whitney J, Willson D, Wynn JL, Yeyha N, Zimmerman JJ. Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary. Pediatrics. 2022 Jan 1; 149: S1-S12.
• Muszynski JA, Banks R, Reeder RW, Hall MW, Berg RA, Zuppa A, Shanley TP, Cornell TT, Newth CJL, Pollack MM, Wessel D, Doctor A, Lin JC, Harrison RE, Meert KL, Dean JM, Holubkov R, Carcillo JA, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. Outcomes Associated With Early RBC Transfusion in Pediatric Severe Sepsis: A Propensity-Adjusted Multicenter Cohort Study. Shock. 2022 Jan 1; 57: 88-94.
• Killien EY, Loftis LL, Clark JD, Muszynski JA, Rissmiller BJ, Singleton MN, White BR, Zimmerman JJ, Maddux AB, Pinto NP, Fink EL, Watson RS, Smith M, Ringwood M, Graham RJ, POST-PICU and PICU-COS Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Networks.. Health-related quality of life outcome measures for children surviving critical care: a scoping review. Qual Life Res. 2021 Dec; 30: 3383-3394.
• Relland LM, Hall M, Martin DP, Nateri J, Hanson-Huber L, Beebe A, Samora W, Klamar J, Muszynski J, Tobias JD. Immune Function following Major Spinal Surgery and General Anesthesia. J Pediatr Intensive Care. 2021 Nov; 10: 248-255.
• Leonard JC, Josephson CD, Luther JF, Wisniewski SR, Allen C, Chiusolo F, Davis AL, Finkelstein RA, Fitzgerald JC, Gaines BA, Goobie SM, Hanson SJ, Hewes HA, Johnson LH, McCollum MO, Muszynski JA, Nair AB, Rosenberg RB, Rouse TM, Sikavitsas A, Singleton MN, Steiner ME, Upperman JS, Vogel AM, Wills H, Winkler MK, Spinella PC. Life-Threatening Bleeding in Children: A Prospective Observational Study. Crit Care Med. 2021 Nov 1; 49: 1943-1954.
• Alexander PMA, Muszynski JA. Ongoing Variability in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation Practices-Could Consensus Change the Next Survey Results? Pediatr Crit Care Med. 2021 Jun 1; 22: 581-584.
• Snyder A, Jedreski K, Fitch J, Wijeratne S, Wetzel A, Hensley J, Flowers M, Bline K, Hall MW, Muszynski JA. Transcriptomic Profiles in Children With Septic Shock With or Without Immunoparalysis. Front Immunol. 2021; 12: 733834.
• Juffermans NP, Aubron C, Duranteau J, Vlaar APJ, Kor DJ, Muszynski JA, Spinella PC, Vincent JL. Transfusion in the mechanically ventilated patient. Intensive Care Med. 2020 Dec; 46: 2450-2457.
• Thakkar RK, Devine R, Popelka J, Hensley J, Fabia R, Muszynski JA, Hall MW. Measures of Systemic Innate Immune Function Predict the Risk of Nosocomial Infection in Pediatric Burn Patients. J Burn Care Res. 2020 Oct 31;
• Bline KE, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Muszynski JA, Ramilo O, Hall MW. Hydrocortisone treatment is associated with a longer duration of MODS in pediatric patients with severe sepsis and immunoparalysis. Crit Care. 2020 Sep 4; 24: 545.
• Willems A, Roeleveld PP, Labarinas S, Cyrus JW, Muszynski JA, Nellis ME, Karam O. Anti-Xa versus time-guided anticoagulation strategies in extracorporeal membrane oxygenation: a systematic review and meta-analysis. Perfusion. 2020 Aug 29; 267659120952982.
• Srouji LS, Moore-Clingenpeel M, Hensley J, Steele L, Greathouse K, Anglim L, Hanson-Huber L, Nateri J, Nicol K, Hall MW, Ramilo O, Muszynski JA. Shock Severity Modifies Associations Between RBC Transfusion in the First 48 Hours of Sepsis Onset and the Duration of Organ Dysfunction in Critically Ill Septic Children. Pediatr Crit Care Med. 2020 Aug; 21: e475-e484.
• Wirtz MR, Almizraq RJ, Weber NC, Norris PJ, Pandey S, Spinella PC, Muszynski JA, P Acker J, Juffermans NP. Red-blood-cell manufacturing methods and storage solutions differentially induce pulmonary cell activation. Vox Sang. 2020 Jul; 115: 395-404.
• Sribnick EA, Hensley J, Moore-Clingenpeel M, Muszynski JA, Thakkar RK, Hall MW. Nosocomial Infection Following Severe Traumatic Injury in Children. Pediatr Crit Care Med. 2020 May; 21: 443-450.
• Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF, ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P.. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019 Dec 10; 322: 2179-2190.
• Menocha S, Muszynski JA. Transfusion-related immune modulation: functional consequence of extracellular vesicles? Transfusion. 2019 Jul 19;
• Thakkar RK, Weiss SL, Fitzgerald JC, Keele L, Thomas NJ, Nadkarni VM, Muszynski JA, Hall MW, SPROUT Investigators., Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis. J Surg Res. 2019 May 7; 242: 100-110.
• Wirtz MR, Jurgens J, Zuurbier CJ, Roelofs JJTH, Spinella PC, Muszynski JA, Carel Goslings J, Juffermans NP. Washing or filtering of blood products does not improve outcome in a rat model of trauma and multiple transfusion. Transfusion. 2019 Jan; 59: 134-145.
• Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (BloodNet), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: 884-898.
• Muszynski JA, Guzzetta NA, Hall MW, Macrae D, Valentine SL, Bateman ST, Spinella PC, Pediatric Critical Care Transfusion and Anemia Expertise Initiative (TAXI)., Pediatric Critical Care Blood Research Network (Blood Net), and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.. Recommendations on RBC Transfusions for Critically Ill Children With Nonhemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatr Crit Care Med. 2018 Sep; 19: S121-S126.
• Almizraq RJ, Norris PJ, Inglis H, Menocha S, Wirtz MR, Juffermans N, Pandey S, Spinella PC, Acker JP, Muszynski JA. Blood manufacturing methods affect red blood cell product characteristics and immunomodulatory activity. Blood Adv. 2018 Sep 25; 2: 2296-2306.
• Muszynski JA, Nofziger R, Moore-Clingenpeel M, Greathouse K, Anglim L, Steele L, Hensley J, Hanson-Huber L, Nateri J, Ramilo O, Hall MW. Early Immune Function and Duration of Organ Dysfunction in Critically III Children with Sepsis. Am J Respir Crit Care Med. 2018 Aug 1; 198: 361-369.
• Muszynski JA, Reeder RW, Hall MW, Berg RA, Shanley TP, Newth CJL, Pollack MM, Wessel D, Carcillo J, Harrison R, Meert KL, Dean JM, Jenkins T, Tamburro RF, Dalton HJ, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN).. RBC Transfusion Practice in Pediatric Extracorporeal Membrane Oxygenation Support. Crit Care Med. 2018 Jun; 46: e552-e559.
• Shah S, Coppolino K, Menocha S, Beceiro S, Nateri J, Spinella PC, Nicol K, Hall MW, Muszynski JA, investigators of the PALISI BloodNet network.. Immunomodulatory effects of plasma products on monocyte function in vitro. J Trauma Acute Care Surg. 2018 Jun; 84: S47-S53.
• Remy KE, Hall MW, Cholette J, Juffermans NP, Nicol K, Doctor A, Blumberg N, Spinella PC, Norris PJ, Dahmer MK, Muszynski JA, Pediatric Critical Care Blood Research Network (Blood Net).. Mechanisms of red blood cell transfusion-related immunomodulation. Transfusion. 2018 Mar; 58: 804-815.
• Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn SA, Hess JR, Klein H, Acker JP, Spinella PC, D’Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon TJ, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration’s public workshop on new red blood cell product regulatory science 2016. Transfusion. 2018 Jan; 58: 255-266.

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2007

Board Certifications

Pediatric Critical Care Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2007

Medical School

Medical College of Ohio at Toledo

Date Completed: 06/04/2004

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2007

Board Certifications

Pediatric Critical Care Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2007

Medical School

Medical College of Ohio at Toledo

Date Completed: 06/04/2004

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2007

Board Certifications

Pediatric Critical Care Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2007

Medical School

Medical College of Ohio at Toledo

Date Completed: 06/04/2004

Date of Appointment at Nationwide Children’s Hospital: 07/01/2007

Board Certifications

Pediatric Critical Care Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2007

Medical School

Medical College of Ohio at Toledo

Date Completed: 06/04/2004

Date of Appointment at Nationwide Children’s Hospital: 07/01/2007

Board Certifications

Pediatric Critical Care Pediatrics

Fellowship

Nationwide Children’s Hospital

Date Completed: 06/30/2011

Residency

Nationwide Children’s Hospital

Date Completed: 06/30/2007

Medical School

Medical College of Ohio at Toledo

Date Completed: 06/04/2004

• Pediatric Critical Care
• Pediatrics

Contact Information

Pediatrics

Call us at: (614) 722-3435

Fax us at: (614) 722-3443

                    Critical Care700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pediatrics

Call us at: (614) 722-3435

Fax us at: (614) 722-3443

                    Critical Care700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pediatrics

Call us at: (614) 722-3435

Fax us at: (614) 722-3443

                    Critical Care700 Children's DrColumbus, OH 43205 (map)

Pediatrics

Call us at: (614) 722-3435

Fax us at: (614) 722-3443

                    Critical Care700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-3435

Fax us at: (614) 722-3443

                    Critical Care700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-3435

Fax us at: (614) 722-3443

                    Critical Care700 Children's DrColumbus, OH 43205 (map)

• Call us at:
• (614) 722-3435
• Fax us at:
• (614) 722-3443
• Critical Care700 Children’s DrColumbus, OH 43205 (map)