Jayajit Das

Contact Information

Call us at: (614)355-5632

Fax us at: (614)355.2728

Email Jayajit Das, PhD

Battelle Center for Mathematical MedicineAbigail Wexner Research Institute700 Children’s DriveColumbus, Ohio 43205 (map)

Learn more about Jayajit Das

Research

Lab(s)

Battelle Center for Mathematical Medicine

Das Lab

My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.

View My Publications Connect on Google Scholar

Featured Publication Das J.  “Physical models in immune signaling.” Systems Immunology: An Introduction to Modeling Methods for Scientists, edited by J. Das and C. Jayaparakash, 1st ed.,  CRC Press, 2019, pp. 227-250. eBook Published 09/2018. Publications

                  Li A, Chang Y, Song NJ, Wu X, Chung D, Riesenberg BP, Velegraki M, Giuliani GD, Das K, Okimoto T, Kwon H, Chakravarthy KB, Bolyard C, Wang Y, He K, Gatti-Mays M, Das J, Yang Y, Gewirth DT, Ma Q, Carbone D, Li Z. Selective targeting of GARP-LTGFß axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity. J Immunother Cancer. 2022 Sep; 10: 

                


                  Grewal RK, Das J. Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation. PLoS Comput Biol. 2022 May; 18: e1010114.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. PLoS Comput Biol. 2022 Mar 21; 18: e1009931.

                


                  Wu Z, Park S, Lau CM, Zhong Y, Sheppard S, Sun JC, Das J, Altan-Bonnet G, Hsu KC. Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness. Sci Signal. 2021 Nov 9; 14: eabe5380.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. bioRxiv. 2021 Apr 27;  

                


                  Jayaprakash C, Das J. Stochastic Sequestration Promotes Specificity in Decision Making in Single Cells. J Phys Chem B. 2019 Dec 12; 123: 10323-10330.

                


                  Wethington D, Harder O, Uppulury K, Stewart WCL, Chen P, King T, Reynolds SD, Perelson AS, Peeples ME, Niewiesk S, Das J. Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats. J R Soc Interface. 2019 Nov 29; 16: 20190389.

                


                  Brown JR, Jurcisek J, Lakhani V, Snedden A, Ray WC, Mokrzan EM, Bakaletz LO, Das J. In Silico Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae In Vivo. mSphere. 2019 Jul 31; 4: 

                


                  Das J, Lanier LL. Data analysis to modeling to building theory in NK cell biology and beyond: How can computational modeling contribute? J Leukoc Biol. 2019 Jun; 105: 1305-1317.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 605.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Corrigendum: Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 2370.

                


                  Lakhani V, Tan L, Mukherjee S, Stewart WCL, Swords WE, Das J. Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media. R Soc Open Sci. 2018 Nov; 5: 180810.

                


                  Jadcherla SR, Prabhakar V, Hasenstab KA, Nawaz S, Das J, Kern M, Balasubramanian G, Shaker R. Defining pharyngeal contractile integral during high-resolution manometry in neonates: a neuromotor marker of pharyngeal vigor. Pediatr Res. 2018 Jul 6;  

                


                  Das J, Mokrzan E, Lakhani V, Rosas L, Jurcisek JA, Ray WC, Bakaletz LO. Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable Haemophilus influenzae. MBio. 2017 Dec 19; 8: 

                


                  Mukherjee S, Stewart D, Stewart W, Lanier LL, Das J. Connecting the dots across time: reconstruction of single-cell signalling trajectories using time-stamped data. R Soc Open Sci. 2017 Aug; 4: 170811.

                


                  Mukherjee S, Jensen H, Stewart W, Stewart D, Ray WC, Chen SY, Nolan GP, Lanier LL, Das J. In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells. Sci Signal. 2017 Jun 27; 10: 

                


                  Sugár IP, Das J, Jayaprakash C, Sealfon SC. Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development. Biophys J. 2017 Mar 14; 112: 997-1009.

View More Publications

Biography

        Jayajit Das, PhD, is a principal investigator in the Battelle Center for Mathematical Medicine at the Research Institute and an Associate Professor of Pediatrics at the Ohio State University. He is also an investigator at the Biophysics program at the Ohio State University, and has a courtesy appointment in the Physics Department at the Ohio State University. Dr. Das's research focuses on uncovering mechanisms underlying innate and adaptive responses in higher organisms using computational and mathematical tools rooted in statistical physics and engineering in synergistic collaboration with experimental labs at the Research Institute and outside the campus.

See Jayajit Das’s Curriculum Vitae (CV)

Academic and Clinical Areas

Battelle Center for Mathematical Medicine

Faculty

Das Lab

Principal Investigator

Primary Department

Battelle Center for Mathematical Medicine

Professional Experience

2016 - Present Associate Professor, Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital2016 - Present Department of Pediatrics, The Ohio State University, Associate Professor2016 - Present Department of Pediatrics, The Ohio State University, Assistant Professor2008 - 2016 Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital, Assistant Professor2005 - 2008 Massachusetts Institute of Technology, Postdoctoral Fellow2002 - 2005 University of California at Berkeley, Postdoctoral Fellow2000 - 2002 Virginia Institute of Polytechnic and State University, Postdoctoral Fellow

Contact Information

Battelle Center for Mathematical Medicine

Call us at: (614)355-5632

Fax us at: (614)355.2728

Email Jayajit Das

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Contact Information

Call us at: (614)355-5632

Fax us at: (614)355.2728

Email Jayajit Das, PhD

Battelle Center for Mathematical MedicineAbigail Wexner Research Institute700 Children’s DriveColumbus, Ohio 43205 (map)

Learn more about Jayajit Das

Research

Lab(s)

Battelle Center for Mathematical Medicine

Das Lab

My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.

View My Publications Connect on Google Scholar

Featured Publication Das J.  “Physical models in immune signaling.” Systems Immunology: An Introduction to Modeling Methods for Scientists, edited by J. Das and C. Jayaparakash, 1st ed.,  CRC Press, 2019, pp. 227-250. eBook Published 09/2018. Publications

                  Li A, Chang Y, Song NJ, Wu X, Chung D, Riesenberg BP, Velegraki M, Giuliani GD, Das K, Okimoto T, Kwon H, Chakravarthy KB, Bolyard C, Wang Y, He K, Gatti-Mays M, Das J, Yang Y, Gewirth DT, Ma Q, Carbone D, Li Z. Selective targeting of GARP-LTGFß axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity. J Immunother Cancer. 2022 Sep; 10: 

                


                  Grewal RK, Das J. Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation. PLoS Comput Biol. 2022 May; 18: e1010114.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. PLoS Comput Biol. 2022 Mar 21; 18: e1009931.

                


                  Wu Z, Park S, Lau CM, Zhong Y, Sheppard S, Sun JC, Das J, Altan-Bonnet G, Hsu KC. Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness. Sci Signal. 2021 Nov 9; 14: eabe5380.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. bioRxiv. 2021 Apr 27;  

                


                  Jayaprakash C, Das J. Stochastic Sequestration Promotes Specificity in Decision Making in Single Cells. J Phys Chem B. 2019 Dec 12; 123: 10323-10330.

                


                  Wethington D, Harder O, Uppulury K, Stewart WCL, Chen P, King T, Reynolds SD, Perelson AS, Peeples ME, Niewiesk S, Das J. Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats. J R Soc Interface. 2019 Nov 29; 16: 20190389.

                


                  Brown JR, Jurcisek J, Lakhani V, Snedden A, Ray WC, Mokrzan EM, Bakaletz LO, Das J. In Silico Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae In Vivo. mSphere. 2019 Jul 31; 4: 

                


                  Das J, Lanier LL. Data analysis to modeling to building theory in NK cell biology and beyond: How can computational modeling contribute? J Leukoc Biol. 2019 Jun; 105: 1305-1317.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 605.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Corrigendum: Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 2370.

                


                  Lakhani V, Tan L, Mukherjee S, Stewart WCL, Swords WE, Das J. Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media. R Soc Open Sci. 2018 Nov; 5: 180810.

                


                  Jadcherla SR, Prabhakar V, Hasenstab KA, Nawaz S, Das J, Kern M, Balasubramanian G, Shaker R. Defining pharyngeal contractile integral during high-resolution manometry in neonates: a neuromotor marker of pharyngeal vigor. Pediatr Res. 2018 Jul 6;  

                


                  Das J, Mokrzan E, Lakhani V, Rosas L, Jurcisek JA, Ray WC, Bakaletz LO. Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable Haemophilus influenzae. MBio. 2017 Dec 19; 8: 

                


                  Mukherjee S, Stewart D, Stewart W, Lanier LL, Das J. Connecting the dots across time: reconstruction of single-cell signalling trajectories using time-stamped data. R Soc Open Sci. 2017 Aug; 4: 170811.

                


                  Mukherjee S, Jensen H, Stewart W, Stewart D, Ray WC, Chen SY, Nolan GP, Lanier LL, Das J. In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells. Sci Signal. 2017 Jun 27; 10: 

                


                  Sugár IP, Das J, Jayaprakash C, Sealfon SC. Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development. Biophys J. 2017 Mar 14; 112: 997-1009.

View More Publications

Biography

        Jayajit Das, PhD, is a principal investigator in the Battelle Center for Mathematical Medicine at the Research Institute and an Associate Professor of Pediatrics at the Ohio State University. He is also an investigator at the Biophysics program at the Ohio State University, and has a courtesy appointment in the Physics Department at the Ohio State University. Dr. Das's research focuses on uncovering mechanisms underlying innate and adaptive responses in higher organisms using computational and mathematical tools rooted in statistical physics and engineering in synergistic collaboration with experimental labs at the Research Institute and outside the campus.

See Jayajit Das’s Curriculum Vitae (CV)

Academic and Clinical Areas

Battelle Center for Mathematical Medicine

Faculty

Das Lab

Principal Investigator

Primary Department

Battelle Center for Mathematical Medicine

Professional Experience

2016 - Present Associate Professor, Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital2016 - Present Department of Pediatrics, The Ohio State University, Associate Professor2016 - Present Department of Pediatrics, The Ohio State University, Assistant Professor2008 - 2016 Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital, Assistant Professor2005 - 2008 Massachusetts Institute of Technology, Postdoctoral Fellow2002 - 2005 University of California at Berkeley, Postdoctoral Fellow2000 - 2002 Virginia Institute of Polytechnic and State University, Postdoctoral Fellow

Contact Information

Battelle Center for Mathematical Medicine

Call us at: (614)355-5632

Fax us at: (614)355.2728

Email Jayajit Das

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Contact Information

Call us at: (614)355-5632

Fax us at: (614)355.2728

Email Jayajit Das, PhD

Battelle Center for Mathematical MedicineAbigail Wexner Research Institute700 Children’s DriveColumbus, Ohio 43205 (map)

Learn more about Jayajit Das

Contact Information

• Call us at:
• (614)355-5632
• Fax us at:
• (614)355.2728
• Email Jayajit Das, PhD
• Battelle Center for Mathematical MedicineAbigail Wexner Research Institute700 Children’s DriveColumbus, Ohio 43205 (map)

Learn more about Jayajit Das

Research

Lab(s)

Battelle Center for Mathematical Medicine

Das Lab

My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.

View My Publications Connect on Google Scholar

Featured Publication Das J.  “Physical models in immune signaling.” Systems Immunology: An Introduction to Modeling Methods for Scientists, edited by J. Das and C. Jayaparakash, 1st ed.,  CRC Press, 2019, pp. 227-250. eBook Published 09/2018. Publications

                  Li A, Chang Y, Song NJ, Wu X, Chung D, Riesenberg BP, Velegraki M, Giuliani GD, Das K, Okimoto T, Kwon H, Chakravarthy KB, Bolyard C, Wang Y, He K, Gatti-Mays M, Das J, Yang Y, Gewirth DT, Ma Q, Carbone D, Li Z. Selective targeting of GARP-LTGFß axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity. J Immunother Cancer. 2022 Sep; 10: 

                


                  Grewal RK, Das J. Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation. PLoS Comput Biol. 2022 May; 18: e1010114.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. PLoS Comput Biol. 2022 Mar 21; 18: e1009931.

                


                  Wu Z, Park S, Lau CM, Zhong Y, Sheppard S, Sun JC, Das J, Altan-Bonnet G, Hsu KC. Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness. Sci Signal. 2021 Nov 9; 14: eabe5380.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. bioRxiv. 2021 Apr 27;  

                


                  Jayaprakash C, Das J. Stochastic Sequestration Promotes Specificity in Decision Making in Single Cells. J Phys Chem B. 2019 Dec 12; 123: 10323-10330.

                


                  Wethington D, Harder O, Uppulury K, Stewart WCL, Chen P, King T, Reynolds SD, Perelson AS, Peeples ME, Niewiesk S, Das J. Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats. J R Soc Interface. 2019 Nov 29; 16: 20190389.

                


                  Brown JR, Jurcisek J, Lakhani V, Snedden A, Ray WC, Mokrzan EM, Bakaletz LO, Das J. In Silico Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae In Vivo. mSphere. 2019 Jul 31; 4: 

                


                  Das J, Lanier LL. Data analysis to modeling to building theory in NK cell biology and beyond: How can computational modeling contribute? J Leukoc Biol. 2019 Jun; 105: 1305-1317.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 605.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Corrigendum: Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 2370.

                


                  Lakhani V, Tan L, Mukherjee S, Stewart WCL, Swords WE, Das J. Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media. R Soc Open Sci. 2018 Nov; 5: 180810.

                


                  Jadcherla SR, Prabhakar V, Hasenstab KA, Nawaz S, Das J, Kern M, Balasubramanian G, Shaker R. Defining pharyngeal contractile integral during high-resolution manometry in neonates: a neuromotor marker of pharyngeal vigor. Pediatr Res. 2018 Jul 6;  

                


                  Das J, Mokrzan E, Lakhani V, Rosas L, Jurcisek JA, Ray WC, Bakaletz LO. Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable Haemophilus influenzae. MBio. 2017 Dec 19; 8: 

                


                  Mukherjee S, Stewart D, Stewart W, Lanier LL, Das J. Connecting the dots across time: reconstruction of single-cell signalling trajectories using time-stamped data. R Soc Open Sci. 2017 Aug; 4: 170811.

                


                  Mukherjee S, Jensen H, Stewart W, Stewart D, Ray WC, Chen SY, Nolan GP, Lanier LL, Das J. In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells. Sci Signal. 2017 Jun 27; 10: 

                


                  Sugár IP, Das J, Jayaprakash C, Sealfon SC. Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development. Biophys J. 2017 Mar 14; 112: 997-1009.

View More Publications

Research

Lab(s)

Battelle Center for Mathematical Medicine

Das Lab

My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.

View My Publications Connect on Google Scholar

Featured Publication Das J.  “Physical models in immune signaling.” Systems Immunology: An Introduction to Modeling Methods for Scientists, edited by J. Das and C. Jayaparakash, 1st ed.,  CRC Press, 2019, pp. 227-250. eBook Published 09/2018. Publications

                  Li A, Chang Y, Song NJ, Wu X, Chung D, Riesenberg BP, Velegraki M, Giuliani GD, Das K, Okimoto T, Kwon H, Chakravarthy KB, Bolyard C, Wang Y, He K, Gatti-Mays M, Das J, Yang Y, Gewirth DT, Ma Q, Carbone D, Li Z. Selective targeting of GARP-LTGFß axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity. J Immunother Cancer. 2022 Sep; 10: 

                


                  Grewal RK, Das J. Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation. PLoS Comput Biol. 2022 May; 18: e1010114.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. PLoS Comput Biol. 2022 Mar 21; 18: e1009931.

                


                  Wu Z, Park S, Lau CM, Zhong Y, Sheppard S, Sun JC, Das J, Altan-Bonnet G, Hsu KC. Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness. Sci Signal. 2021 Nov 9; 14: eabe5380.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. bioRxiv. 2021 Apr 27;  

                


                  Jayaprakash C, Das J. Stochastic Sequestration Promotes Specificity in Decision Making in Single Cells. J Phys Chem B. 2019 Dec 12; 123: 10323-10330.

                


                  Wethington D, Harder O, Uppulury K, Stewart WCL, Chen P, King T, Reynolds SD, Perelson AS, Peeples ME, Niewiesk S, Das J. Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats. J R Soc Interface. 2019 Nov 29; 16: 20190389.

                


                  Brown JR, Jurcisek J, Lakhani V, Snedden A, Ray WC, Mokrzan EM, Bakaletz LO, Das J. In Silico Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae In Vivo. mSphere. 2019 Jul 31; 4: 

                


                  Das J, Lanier LL. Data analysis to modeling to building theory in NK cell biology and beyond: How can computational modeling contribute? J Leukoc Biol. 2019 Jun; 105: 1305-1317.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 605.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Corrigendum: Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 2370.

                


                  Lakhani V, Tan L, Mukherjee S, Stewart WCL, Swords WE, Das J. Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media. R Soc Open Sci. 2018 Nov; 5: 180810.

                


                  Jadcherla SR, Prabhakar V, Hasenstab KA, Nawaz S, Das J, Kern M, Balasubramanian G, Shaker R. Defining pharyngeal contractile integral during high-resolution manometry in neonates: a neuromotor marker of pharyngeal vigor. Pediatr Res. 2018 Jul 6;  

                


                  Das J, Mokrzan E, Lakhani V, Rosas L, Jurcisek JA, Ray WC, Bakaletz LO. Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable Haemophilus influenzae. MBio. 2017 Dec 19; 8: 

                


                  Mukherjee S, Stewart D, Stewart W, Lanier LL, Das J. Connecting the dots across time: reconstruction of single-cell signalling trajectories using time-stamped data. R Soc Open Sci. 2017 Aug; 4: 170811.

                


                  Mukherjee S, Jensen H, Stewart W, Stewart D, Ray WC, Chen SY, Nolan GP, Lanier LL, Das J. In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells. Sci Signal. 2017 Jun 27; 10: 

                


                  Sugár IP, Das J, Jayaprakash C, Sealfon SC. Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development. Biophys J. 2017 Mar 14; 112: 997-1009.

View More Publications

Research

Lab(s)

Battelle Center for Mathematical Medicine

Das Lab

My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.

View My Publications Connect on Google Scholar

Featured Publication Das J.  “Physical models in immune signaling.” Systems Immunology: An Introduction to Modeling Methods for Scientists, edited by J. Das and C. Jayaparakash, 1st ed.,  CRC Press, 2019, pp. 227-250. eBook Published 09/2018. Publications

                  Li A, Chang Y, Song NJ, Wu X, Chung D, Riesenberg BP, Velegraki M, Giuliani GD, Das K, Okimoto T, Kwon H, Chakravarthy KB, Bolyard C, Wang Y, He K, Gatti-Mays M, Das J, Yang Y, Gewirth DT, Ma Q, Carbone D, Li Z. Selective targeting of GARP-LTGFß axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity. J Immunother Cancer. 2022 Sep; 10: 

                


                  Grewal RK, Das J. Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation. PLoS Comput Biol. 2022 May; 18: e1010114.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. PLoS Comput Biol. 2022 Mar 21; 18: e1009931.

                


                  Wu Z, Park S, Lau CM, Zhong Y, Sheppard S, Sun JC, Das J, Altan-Bonnet G, Hsu KC. Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness. Sci Signal. 2021 Nov 9; 14: eabe5380.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. bioRxiv. 2021 Apr 27;  

                


                  Jayaprakash C, Das J. Stochastic Sequestration Promotes Specificity in Decision Making in Single Cells. J Phys Chem B. 2019 Dec 12; 123: 10323-10330.

                


                  Wethington D, Harder O, Uppulury K, Stewart WCL, Chen P, King T, Reynolds SD, Perelson AS, Peeples ME, Niewiesk S, Das J. Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats. J R Soc Interface. 2019 Nov 29; 16: 20190389.

                


                  Brown JR, Jurcisek J, Lakhani V, Snedden A, Ray WC, Mokrzan EM, Bakaletz LO, Das J. In Silico Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae In Vivo. mSphere. 2019 Jul 31; 4: 

                


                  Das J, Lanier LL. Data analysis to modeling to building theory in NK cell biology and beyond: How can computational modeling contribute? J Leukoc Biol. 2019 Jun; 105: 1305-1317.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 605.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Corrigendum: Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 2370.

                


                  Lakhani V, Tan L, Mukherjee S, Stewart WCL, Swords WE, Das J. Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media. R Soc Open Sci. 2018 Nov; 5: 180810.

                


                  Jadcherla SR, Prabhakar V, Hasenstab KA, Nawaz S, Das J, Kern M, Balasubramanian G, Shaker R. Defining pharyngeal contractile integral during high-resolution manometry in neonates: a neuromotor marker of pharyngeal vigor. Pediatr Res. 2018 Jul 6;  

                


                  Das J, Mokrzan E, Lakhani V, Rosas L, Jurcisek JA, Ray WC, Bakaletz LO. Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable Haemophilus influenzae. MBio. 2017 Dec 19; 8: 

                


                  Mukherjee S, Stewart D, Stewart W, Lanier LL, Das J. Connecting the dots across time: reconstruction of single-cell signalling trajectories using time-stamped data. R Soc Open Sci. 2017 Aug; 4: 170811.

                


                  Mukherjee S, Jensen H, Stewart W, Stewart D, Ray WC, Chen SY, Nolan GP, Lanier LL, Das J. In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells. Sci Signal. 2017 Jun 27; 10: 

                


                  Sugár IP, Das J, Jayaprakash C, Sealfon SC. Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development. Biophys J. 2017 Mar 14; 112: 997-1009.

View More Publications

Lab(s)

Battelle Center for Mathematical Medicine

Das Lab

My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.

View My Publications Connect on Google Scholar

Featured Publication Das J.  “Physical models in immune signaling.” Systems Immunology: An Introduction to Modeling Methods for Scientists, edited by J. Das and C. Jayaparakash, 1st ed.,  CRC Press, 2019, pp. 227-250. eBook Published 09/2018. Publications

                  Li A, Chang Y, Song NJ, Wu X, Chung D, Riesenberg BP, Velegraki M, Giuliani GD, Das K, Okimoto T, Kwon H, Chakravarthy KB, Bolyard C, Wang Y, He K, Gatti-Mays M, Das J, Yang Y, Gewirth DT, Ma Q, Carbone D, Li Z. Selective targeting of GARP-LTGFß axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity. J Immunother Cancer. 2022 Sep; 10: 

                


                  Grewal RK, Das J. Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation. PLoS Comput Biol. 2022 May; 18: e1010114.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. PLoS Comput Biol. 2022 Mar 21; 18: e1009931.

                


                  Wu Z, Park S, Lau CM, Zhong Y, Sheppard S, Sun JC, Das J, Altan-Bonnet G, Hsu KC. Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness. Sci Signal. 2021 Nov 9; 14: eabe5380.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. bioRxiv. 2021 Apr 27;  

                


                  Jayaprakash C, Das J. Stochastic Sequestration Promotes Specificity in Decision Making in Single Cells. J Phys Chem B. 2019 Dec 12; 123: 10323-10330.

                


                  Wethington D, Harder O, Uppulury K, Stewart WCL, Chen P, King T, Reynolds SD, Perelson AS, Peeples ME, Niewiesk S, Das J. Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats. J R Soc Interface. 2019 Nov 29; 16: 20190389.

                


                  Brown JR, Jurcisek J, Lakhani V, Snedden A, Ray WC, Mokrzan EM, Bakaletz LO, Das J. In Silico Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae In Vivo. mSphere. 2019 Jul 31; 4: 

                


                  Das J, Lanier LL. Data analysis to modeling to building theory in NK cell biology and beyond: How can computational modeling contribute? J Leukoc Biol. 2019 Jun; 105: 1305-1317.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 605.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Corrigendum: Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 2370.

                


                  Lakhani V, Tan L, Mukherjee S, Stewart WCL, Swords WE, Das J. Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media. R Soc Open Sci. 2018 Nov; 5: 180810.

                


                  Jadcherla SR, Prabhakar V, Hasenstab KA, Nawaz S, Das J, Kern M, Balasubramanian G, Shaker R. Defining pharyngeal contractile integral during high-resolution manometry in neonates: a neuromotor marker of pharyngeal vigor. Pediatr Res. 2018 Jul 6;  

                


                  Das J, Mokrzan E, Lakhani V, Rosas L, Jurcisek JA, Ray WC, Bakaletz LO. Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable Haemophilus influenzae. MBio. 2017 Dec 19; 8: 

                


                  Mukherjee S, Stewart D, Stewart W, Lanier LL, Das J. Connecting the dots across time: reconstruction of single-cell signalling trajectories using time-stamped data. R Soc Open Sci. 2017 Aug; 4: 170811.

                


                  Mukherjee S, Jensen H, Stewart W, Stewart D, Ray WC, Chen SY, Nolan GP, Lanier LL, Das J. In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells. Sci Signal. 2017 Jun 27; 10: 

                


                  Sugár IP, Das J, Jayaprakash C, Sealfon SC. Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development. Biophys J. 2017 Mar 14; 112: 997-1009.

View More Publications

Lab(s)

Battelle Center for Mathematical Medicine

Das Lab

My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.

Lab(s)

Battelle Center for Mathematical Medicine

Das Lab

• Battelle Center for Mathematical Medicine

• Das Lab

• View My Publications

• Connect on Google Scholar

Featured Publication

Das J.  “Physical models in immune signaling.” Systems Immunology: An Introduction to Modeling Methods for Scientists, edited by J. Das and C. Jayaparakash, 1st ed.,  CRC Press, 2019, pp. 227-250. eBook Published 09/2018.

                  Li A, Chang Y, Song NJ, Wu X, Chung D, Riesenberg BP, Velegraki M, Giuliani GD, Das K, Okimoto T, Kwon H, Chakravarthy KB, Bolyard C, Wang Y, He K, Gatti-Mays M, Das J, Yang Y, Gewirth DT, Ma Q, Carbone D, Li Z. Selective targeting of GARP-LTGFß axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity. J Immunother Cancer. 2022 Sep; 10: 

                


                  Grewal RK, Das J. Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation. PLoS Comput Biol. 2022 May; 18: e1010114.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. PLoS Comput Biol. 2022 Mar 21; 18: e1009931.

                


                  Wu Z, Park S, Lau CM, Zhong Y, Sheppard S, Sun JC, Das J, Altan-Bonnet G, Hsu KC. Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness. Sci Signal. 2021 Nov 9; 14: eabe5380.

                


                  Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. bioRxiv. 2021 Apr 27;  

                


                  Jayaprakash C, Das J. Stochastic Sequestration Promotes Specificity in Decision Making in Single Cells. J Phys Chem B. 2019 Dec 12; 123: 10323-10330.

                


                  Wethington D, Harder O, Uppulury K, Stewart WCL, Chen P, King T, Reynolds SD, Perelson AS, Peeples ME, Niewiesk S, Das J. Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats. J R Soc Interface. 2019 Nov 29; 16: 20190389.

                


                  Brown JR, Jurcisek J, Lakhani V, Snedden A, Ray WC, Mokrzan EM, Bakaletz LO, Das J. In Silico Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae In Vivo. mSphere. 2019 Jul 31; 4: 

                


                  Das J, Lanier LL. Data analysis to modeling to building theory in NK cell biology and beyond: How can computational modeling contribute? J Leukoc Biol. 2019 Jun; 105: 1305-1317.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 605.

                


                  Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Corrigendum: Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 2370.

                


                  Lakhani V, Tan L, Mukherjee S, Stewart WCL, Swords WE, Das J. Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media. R Soc Open Sci. 2018 Nov; 5: 180810.

                


                  Jadcherla SR, Prabhakar V, Hasenstab KA, Nawaz S, Das J, Kern M, Balasubramanian G, Shaker R. Defining pharyngeal contractile integral during high-resolution manometry in neonates: a neuromotor marker of pharyngeal vigor. Pediatr Res. 2018 Jul 6;  

                


                  Das J, Mokrzan E, Lakhani V, Rosas L, Jurcisek JA, Ray WC, Bakaletz LO. Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable Haemophilus influenzae. MBio. 2017 Dec 19; 8: 

                


                  Mukherjee S, Stewart D, Stewart W, Lanier LL, Das J. Connecting the dots across time: reconstruction of single-cell signalling trajectories using time-stamped data. R Soc Open Sci. 2017 Aug; 4: 170811.

                


                  Mukherjee S, Jensen H, Stewart W, Stewart D, Ray WC, Chen SY, Nolan GP, Lanier LL, Das J. In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells. Sci Signal. 2017 Jun 27; 10: 

                


                  Sugár IP, Das J, Jayaprakash C, Sealfon SC. Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development. Biophys J. 2017 Mar 14; 112: 997-1009.

View More Publications

• Li A, Chang Y, Song NJ, Wu X, Chung D, Riesenberg BP, Velegraki M, Giuliani GD, Das K, Okimoto T, Kwon H, Chakravarthy KB, Bolyard C, Wang Y, He K, Gatti-Mays M, Das J, Yang Y, Gewirth DT, Ma Q, Carbone D, Li Z. Selective targeting of GARP-LTGFß axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8+ T cell antitumor immunity. J Immunother Cancer. 2022 Sep; 10:
• Grewal RK, Das J. Spatially resolved in silico modeling of NKG2D signaling kinetics suggests a key role of NKG2D and Vav1 Co-clustering in generating natural killer cell activation. PLoS Comput Biol. 2022 May; 18: e1010114.
• Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. PLoS Comput Biol. 2022 Mar 21; 18: e1009931.
• Wu Z, Park S, Lau CM, Zhong Y, Sheppard S, Sun JC, Das J, Altan-Bonnet G, Hsu KC. Dynamic variability in SHP-1 abundance determines natural killer cell responsiveness. Sci Signal. 2021 Nov 9; 14: eabe5380.
• Mukherjee S, Wethington D, Dey TK, Das J. Determining clinically relevant features in cytometry data using persistent homology. bioRxiv. 2021 Apr 27;
• Jayaprakash C, Das J. Stochastic Sequestration Promotes Specificity in Decision Making in Single Cells. J Phys Chem B. 2019 Dec 12; 123: 10323-10330.
• Wethington D, Harder O, Uppulury K, Stewart WCL, Chen P, King T, Reynolds SD, Perelson AS, Peeples ME, Niewiesk S, Das J. Mathematical modelling identifies the role of adaptive immunity as a key controller of respiratory syncytial virus in cotton rats. J R Soc Interface. 2019 Nov 29; 16: 20190389.
• Brown JR, Jurcisek J, Lakhani V, Snedden A, Ray WC, Mokrzan EM, Bakaletz LO, Das J. In Silico Modeling of Biofilm Formation by Nontypeable Haemophilus influenzae In Vivo. mSphere. 2019 Jul 31; 4:
• Das J, Lanier LL. Data analysis to modeling to building theory in NK cell biology and beyond: How can computational modeling contribute? J Leukoc Biol. 2019 Jun; 105: 1305-1317.
• Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 605.
• Mbiribindi B, Mukherjee S, Wellington D, Das J, Khakoo SI. Corrigendum: Spatial Clustering of Receptors and Signaling Molecules Regulates NK Cell Response to Peptide Repertoire Changes. Front Immunol. 2019; 10: 2370.
• Lakhani V, Tan L, Mukherjee S, Stewart WCL, Swords WE, Das J. Mutations in bacterial genes induce unanticipated changes in the relationship between bacterial pathogens in experimental otitis media. R Soc Open Sci. 2018 Nov; 5: 180810.
• Jadcherla SR, Prabhakar V, Hasenstab KA, Nawaz S, Das J, Kern M, Balasubramanian G, Shaker R. Defining pharyngeal contractile integral during high-resolution manometry in neonates: a neuromotor marker of pharyngeal vigor. Pediatr Res. 2018 Jul 6;
• Das J, Mokrzan E, Lakhani V, Rosas L, Jurcisek JA, Ray WC, Bakaletz LO. Extracellular DNA and Type IV Pilus Expression Regulate the Structure and Kinetics of Biofilm Formation by Nontypeable Haemophilus influenzae. MBio. 2017 Dec 19; 8:
• Mukherjee S, Stewart D, Stewart W, Lanier LL, Das J. Connecting the dots across time: reconstruction of single-cell signalling trajectories using time-stamped data. R Soc Open Sci. 2017 Aug; 4: 170811.
• Mukherjee S, Jensen H, Stewart W, Stewart D, Ray WC, Chen SY, Nolan GP, Lanier LL, Das J. In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells. Sci Signal. 2017 Jun 27; 10:
• Sugár IP, Das J, Jayaprakash C, Sealfon SC. Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development. Biophys J. 2017 Mar 14; 112: 997-1009.

Biography

        Jayajit Das, PhD, is a principal investigator in the Battelle Center for Mathematical Medicine at the Research Institute and an Associate Professor of Pediatrics at the Ohio State University. He is also an investigator at the Biophysics program at the Ohio State University, and has a courtesy appointment in the Physics Department at the Ohio State University. Dr. Das's research focuses on uncovering mechanisms underlying innate and adaptive responses in higher organisms using computational and mathematical tools rooted in statistical physics and engineering in synergistic collaboration with experimental labs at the Research Institute and outside the campus.

See Jayajit Das’s Curriculum Vitae (CV)

Biography

        Jayajit Das, PhD, is a principal investigator in the Battelle Center for Mathematical Medicine at the Research Institute and an Associate Professor of Pediatrics at the Ohio State University. He is also an investigator at the Biophysics program at the Ohio State University, and has a courtesy appointment in the Physics Department at the Ohio State University. Dr. Das's research focuses on uncovering mechanisms underlying innate and adaptive responses in higher organisms using computational and mathematical tools rooted in statistical physics and engineering in synergistic collaboration with experimental labs at the Research Institute and outside the campus.

See Jayajit Das’s Curriculum Vitae (CV)

Biography

        Jayajit Das, PhD, is a principal investigator in the Battelle Center for Mathematical Medicine at the Research Institute and an Associate Professor of Pediatrics at the Ohio State University. He is also an investigator at the Biophysics program at the Ohio State University, and has a courtesy appointment in the Physics Department at the Ohio State University. Dr. Das's research focuses on uncovering mechanisms underlying innate and adaptive responses in higher organisms using computational and mathematical tools rooted in statistical physics and engineering in synergistic collaboration with experimental labs at the Research Institute and outside the campus.

See Jayajit Das’s Curriculum Vitae (CV)

        Jayajit Das, PhD, is a principal investigator in the Battelle Center for Mathematical Medicine at the Research Institute and an Associate Professor of Pediatrics at the Ohio State University. He is also an investigator at the Biophysics program at the Ohio State University, and has a courtesy appointment in the Physics Department at the Ohio State University. Dr. Das's research focuses on uncovering mechanisms underlying innate and adaptive responses in higher organisms using computational and mathematical tools rooted in statistical physics and engineering in synergistic collaboration with experimental labs at the Research Institute and outside the campus.

See Jayajit Das’s Curriculum Vitae (CV)

See Jayajit Das’s Curriculum Vitae (CV)

Academic and Clinical Areas

Battelle Center for Mathematical Medicine

Faculty

Das Lab

Principal Investigator

Primary Department

Battelle Center for Mathematical Medicine

Academic and Clinical Areas

Battelle Center for Mathematical Medicine

Faculty

Das Lab

Principal Investigator

Primary Department

Battelle Center for Mathematical Medicine

Academic and Clinical Areas

Battelle Center for Mathematical Medicine

Faculty

Das Lab

Principal Investigator

Primary Department

Battelle Center for Mathematical Medicine

Battelle Center for Mathematical Medicine

Faculty

Das Lab

Principal Investigator

Primary Department

Battelle Center for Mathematical Medicine

• Battelle Center for Mathematical Medicine
• Faculty
• Das Lab
• Principal Investigator
• Primary Department
• Battelle Center for Mathematical Medicine

Professional Experience

2016 - Present Associate Professor, Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital2016 - Present Department of Pediatrics, The Ohio State University, Associate Professor2016 - Present Department of Pediatrics, The Ohio State University, Assistant Professor2008 - 2016 Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital, Assistant Professor2005 - 2008 Massachusetts Institute of Technology, Postdoctoral Fellow2002 - 2005 University of California at Berkeley, Postdoctoral Fellow2000 - 2002 Virginia Institute of Polytechnic and State University, Postdoctoral Fellow

Professional Experience

2016 - Present Associate Professor, Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital2016 - Present Department of Pediatrics, The Ohio State University, Associate Professor2016 - Present Department of Pediatrics, The Ohio State University, Assistant Professor2008 - 2016 Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital, Assistant Professor2005 - 2008 Massachusetts Institute of Technology, Postdoctoral Fellow2002 - 2005 University of California at Berkeley, Postdoctoral Fellow2000 - 2002 Virginia Institute of Polytechnic and State University, Postdoctoral Fellow

Professional Experience

2016 - Present Associate Professor, Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital2016 - Present Department of Pediatrics, The Ohio State University, Associate Professor2016 - Present Department of Pediatrics, The Ohio State University, Assistant Professor2008 - 2016 Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital, Assistant Professor2005 - 2008 Massachusetts Institute of Technology, Postdoctoral Fellow2002 - 2005 University of California at Berkeley, Postdoctoral Fellow2000 - 2002 Virginia Institute of Polytechnic and State University, Postdoctoral Fellow

2016 - Present Associate Professor, Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital2016 - Present Department of Pediatrics, The Ohio State University, Associate Professor2016 - Present Department of Pediatrics, The Ohio State University, Assistant Professor2008 - 2016 Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital, Assistant Professor2005 - 2008 Massachusetts Institute of Technology, Postdoctoral Fellow2002 - 2005 University of California at Berkeley, Postdoctoral Fellow2000 - 2002 Virginia Institute of Polytechnic and State University, Postdoctoral Fellow

2016 - Present Associate Professor, Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital

Contact Information

Battelle Center for Mathematical Medicine

Call us at: (614)355-5632

Fax us at: (614)355.2728

Email Jayajit Das

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Contact Information

Battelle Center for Mathematical Medicine

Call us at: (614)355-5632

Fax us at: (614)355.2728

Email Jayajit Das

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Contact Information

Battelle Center for Mathematical Medicine

Call us at: (614)355-5632

Fax us at: (614)355.2728

Email Jayajit Das

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Battelle Center for Mathematical Medicine

Call us at: (614)355-5632

Fax us at: (614)355.2728

Email Jayajit Das

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Call us at: (614)355-5632

Fax us at: (614)355.2728

Email Jayajit Das

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

Call us at: (614)355-5632

Fax us at: (614)355.2728

Email Jayajit Das

                    Abigail Wexner Research Institute700 Children's DriveColumbus, Ohio 43205 (map)

• Call us at:
• (614)355-5632
• Fax us at:
• (614)355.2728
• Email Jayajit Das
• Abigail Wexner Research Institute700 Children’s DriveColumbus, Ohio 43205 (map)