Contact Information

Call us at: (614) 722-3900

Fax us at: (614) 722-3903

General Pediatric SurgeryPediatric Surgery700 Children’s DrColumbus, OH 43205 (map)

Learn more about Gail E. Besner

Biography

Gail E. Besner, MD, is Chief of Pediatric Surgery at Nationwide Children’s Hospital. She is also a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital and Associate Program Director of the Pediatric Surgery Residency program. She also holds the H. William Clatworthy Jr. Professorship in Surgery at The Ohio State University College of Medicine and is a Professor of Surgery and Pediatrics at The Ohio State University College of Medicine. Dr. Besner’s clinical interests include neonatal surgery, necrotizing enterocolitis, and pediatric burn care. Her research interests involve the identification of novel strategies to protect the intestines from injury using growth factors and stem cells, as well as the production of tissue engineered intestine. Dr. Besner’s research has been continually funded by grants from the National Institutes of Health for over two decades. Dr. Besner is currently serving a 4-year term as a member of the National Institute of General Medical Sciences Advisory Council of the National Institutes of Health.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Nationwide Children’s Hospital Toledo

Academic and Clinical Areas

Pediatric Surgery

Chief

Surgical Services

Service Line Chief

Pediatric Surgery Residency

Associate Program Director

Trauma

Surgeon Team

Neonatology

Principal Investigator

Center for Perinatal Research

Principal Investigator

Pediatric Colorectal Research Fellowship

Faculty

Surgical Critical Care Fellowship

Faculty

Primary Department

General Pediatric Surgery

Awards, Honors & Organizations

Research Award, Platinum First Place Award Winner - Resident’s Paper Competition (RS), Presidential Symposium, Columbus Surgical Society, 2018 Researcher Spotlight Journal Recognition, 2018 Oral Presentation Research Award, Third Place Award (RS), The Ohio State University Department of Surgery Research Day, 2018 Advocate in Medicine Award, Ethiopian Tewahedo Social Services (ETSS), 2017 Outstanding Resident Presentation Award (CM), Association of Academic Surgery, 2017 Research Award, Gold Medal Winner - Resident’s Paper Competition (CM), Presidential Symposium, Columbus Surgical Society, 2017 Best Poster Award, First Place Award – Resident’s Poster Competition (JO), Center for Regenerative Medicine and Cell Based Therapies 10th Annual Regenerative Medicine and Wound Care Conference, 2017 Best Poster Award, Bronze Prize Winner – Research Scientist Poster Competition (YZ), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, 2017 Quality Award for Value in Surgery (AN), American Pediatric Surgical Association Meeting, 2017 Best Oral Presentation Award, First Place Award (BC), Vidant Medical Center Medical Staff Graduate Medical Education Research Day, East Carolina State University, 2017 Oral Presentation Research Award, Second Place Award (CM), The Ohio State University Department of Surgery Research Day, 2017 Summer Student Poster Presentation Award, First Place College Student Award (SD), The Research Institute at Nationwide Children’s Hospital Summer Student Poster Competition, 2017 Spring Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital, 2016 Fall Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital (CM), 2016 Research Poster Award, First Place Poster Award (SG), The Research Institute at Nationwide Children’s Hospital, Student Research Symposium, Columbus, Ohio, 2016 Rosencrantz Resident Research Award, Best Basic Science Research Presentation Award (CM), American Academy of Pediatrics Section on Surgery, 2016 Best Manuscript by a New AAS Member, Academic Surgical Conference, 2016 Research Award, Oral Presentation (YW), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016 Best Poster Award, Bronze Prize Winner – Resident’s Poster Competition (BC), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, Columbus, Ohio, 2016 Medical Student Travel Award, The Ohio State University College of Medicine (SG), 2016 Excellence in Innovation Award Recipient, “HB-EGF for Use in Methods of Treating and Preventing Intestinal Injury Related to Hemorrhagic Shock and Resusc, The Research Institute at Nationwide Children’s Hospital, 2016 Third Place Prize Winner – Student Research Competition (SG), Pediatric Medical Student Research Forum, Orlando, FL, 2016 Research Award - First Place Research Poster Award, Clinical Fellow Category (JO), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016 Research Award, Platinum Prize Winner - Resident’s Paper Competition (JO), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016 Research Award, Bronze Prize Winner - Resident’s Paper Competition (BC), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016 Research Award, First Place Basic Science Poster Award (DM), Association of Indian Physicians of Northern Ohio Annual Research Symposium, Cleveland, OH, 2016 Career Contribution Award Recipient, Nationwide Children’s Hospital, 2012 Listed, Best Doctors in America

Research

Lab(s)

Center for Perinatal Research

Dr. Gail Besner’s primary research began in 1990 with the identification of the growth factor “heparin-binding EGF-like growth factor” (HB-EGF). The long range goal of this research is determine whether or not HB-EGF could be used in therapies to protect and treat intestinal damage in high-risk neonates. Her studies have shown that HB-EGF’s anti-inflammatory effects and chemical properties play a vital role in the regenerating of intestinal cells after they have been damaged. Lab research has shown that HB-EGF can protect the intestine from damage caused by hemorrhagic shock, blood supply restriction and necrotizing enterocolitis. Clinical studies are on the horizon to further test HB-EGF as a treatment option. Publications

                  Ettinger NA, Hill VL, Russ CM, Rakoczy KJ, Fallat ME, Wright TN, Choong K, Agus MSD, Hsu B, SECTION ON CRITICAL CARE, COMMITTEE ON HOSPITAL CARE, SECTION ON SURGERY., Mack E, Day S, Lowrie L, Siegel L, Srinivasan V, Gadepalli S, Hirshberg EL, Kissoon N, October T, Tamburro RF, Rotta A, Tellez S, Rauch DA, Ernst K, Vinocur C, Lam VT, Romito B, Hanson N, Gigli KH, Mauro M, Leonard MS, Alexander SN, Davidoff A, Besner GE, Browne M, Downard CD, Gow KW, Islam S, Saunders Walsh D, Williams RF, Thorne V. Guidance for Structuring a Pediatric Intermediate Care Unit. Pediatrics. 2022 May 1; 149: 

                


                  Dunn M, Savoie K, Erdem G, Dykes MW, Buckingham D, Spencer S, Besner G, Kenney B. Quality improvement methodology can reduce hospitalisation for abscess management. Emerg Med J. 2022 Jan 11;  

                


                  Ragan MV, Wala SJ, Goodman SD, Bailey MT, Besner GE. Next-Generation Probiotic Therapy to Protect the Intestines From Injury. Front Cell Infect Microbiol. 2022; 12: 863949.

                


                  Galley JD, Mar P, Wang Y, Han R, Rajab A, Besner GE. Urine-derived extracellular vesicle miRNAs as possible biomarkers for and mediators of necrotizing enterocolitis: A proof of concept study. J Pediatr Surg. 2021 Nov; 56: 1966-1975.

                


                  Blakely ML, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK, Besner GE, Das A, Ohls RK, Truog WE, Nelin LD, Poindexter BB, Pedroza C, Walsh MC, Stoll BJ, Geller R, Kennedy KA, Dimmitt RA, Carlo WA, Cotten CM, Laptook AR, Van Meurs KP, Calkins KL, Sokol GM, Sanchez PJ, Wyckoff MH, Patel RM, Frantz ID 3rd, Shankaran S, D'Angio CT, Yoder BA, Bell EF, Watterberg KL, Martin CA, Harmon CM, Rice H, Kurkchubasche AG, Sylvester K, Dunn JCY, Markel TA, Diesen DL, Bhatia AM, Flake A, Chwals WJ, Brown R, Bass KD, St Peter SD, Shanti CM, Pegoli W Jr, Skarda D, Shilyansky J, Lemon DG, Mosquera RA, Peralta-Carcelen M, Goldstein RF, Vohr BR, Purdy IB, Hines AC, Maitre NL, Heyne RJ, DeMauro SB, McGowan EC, Yolton K, Kilbride HW, Natarajan G, Yost K, Winter S, Colaizy TT, Laughon MM, Lakshminrusimha S, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network.. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial. Ann Surg. 2021 Oct 1; 274: e370-e380.

                


                  Shelby RD, Mar P, Janzow GE, Mashburn-Warren L, Tengberg N, Navarro JB, Allen JM, Wickham J, Wang Y, Bailey MT, Goodman SD, Besner GE. Antibacterial and anti-inflammatory effects of Lactobacillus reuteri in its biofilm state contribute to its beneficial effects in a rat model of experimental necrotizing enterocolitis. J Pediatr Surg. 2021 Sep 20;  

                


                  Brigstock NM, Besner GE. Development of an academic RVU (aRVU) system to promote pediatric surgical academic productivity. J Pediatr Surg. 2021 Sep 20;  

                


                  Wang Y, Jaggers RM, Mar P, Galley JD, Shaffer T, Rajab A, Deshpande S, Mashburn-Warren L, Buzzo JR, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in its biofilm state promotes neurodevelopment after experimental necrotizing enterocolitis in rats. Brain Behav Immun Health. 2021 Jul; 14: 

                


                  Al-Hadidi A, Navarro J, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in Its Biofilm State Improves Protection from Experimental Necrotizing Enterocolitis. Nutrients. 2021 Mar 12; 13: 

                


                  Lawrence AE, Huntington JT, Savoie K, Dykes M, Aldrink JH, Richards H, Besner GE, Kenney B, Fisher J, Minneci PC, Michalsky MP. Improving care through standardized treatment of spontaneous pneumothorax. J Pediatr Surg. 2021 Jan; 56: 55-60.

                


                  Nitkin CR, Rajasingh J, Pisano C, Besner GE, Thébaud B, Sampath V. Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Pediatr Res. 2020 Jan; 87: 265-276.

                


                  Pisano C, Galley J, Elbahrawy M, Wang Y, Farrell A, Brigstock D, Besner GE. Human Breast Milk-Derived Extracellular Vesicles in the Protection Against Experimental Necrotizing Enterocolitis. J Pediatr Surg. 2020 Jan; 55: 54-58.

                


                  Savoie KB, Shelby RD, Dykes MW, Diefenbach KA, Besner GE, Kenney BD. Volume of Irrigation Does Not Affect Rate of Abscess in Perforated Appendicitis. J Laparoendosc Adv Surg Tech A. 2019 Oct; 29: 1232-1238.

                


                  Shelby RD, Tengberg N, Conces M, Olson JK, Navarro JB, Bailey MT, Goodman SD, Besner GE. Development of a Standardized Scoring System to Assess a Murine Model of Clostridium difficile Colitis. J Invest Surg. 2019 Mar 20;  1-9.

                


                  Shelby RD, Cromeens B, Rager TM, Besner GE. Influence of Growth Factors on the Development of Necrotizing Enterocolitis. Clin Perinatol. 2019 Mar; 46: 51-64.

                


                  Perrone EE, Olson J, Golden JM, Besner GE, Gayer CP, Islam S, Gollin G. Closing gastroschisis: The good, the bad, and the not-so ugly. J Pediatr Surg. 2019 Jan; 54: 60-64.

                


                  Nordin AB, Diefenbach K, Sales SP, Christensen J, Besner GE, Kenney BD. Gangrenous appendicitis: No longer complicated. J Pediatr Surg. 2018 Nov 6;  

                


                  Liu Y, Wang Y, Chakroff J, Johnson J, Farrell A, Besner GE. Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors. Tissue Eng Part A. 2018 Oct 4;  

                


                  Pisano C, Besner GE. Potential role of stem cells in disease prevention based on a murine model of experimental necrotizing enterocolitis. J Pediatr Surg. 2018 Sep 5;  

                


                  Olson JK, Navarro JB, Allen JM, McCulloh CJ, Mashburn-Warren L, Wang Y, Varaljay VA, Bailey MT, Goodman SD, Besner GE. An enhanced Lactobacillus reuteri biofilm formulation that increases protection against experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2018 Sep 1; 315: G408-G419.

                


                  Liu Y, Nelson T, Chakroff J, Cromeens B, Johnson J, Lannutti J, Besner GE. Comparison of polyglycolic acid, polycaprolactone, and collagen as scaffolds for the production of tissue engineered intestine. J Biomed Mater Res B Appl Biomater. 2018 Sep 30;  

                


                  McCulloh CJ, Olson JK, Wang Y, Zhou Y, Tengberg NH, Deshpande S, Besner GE. Treatment of experimental necrotizing enterocolitis with stem cell-derived exosomes. J Pediatr Surg. 2018 Jun; 53: 1215-1220.

                


                  Liu Y, Cromeens BP, Wang Y, Fisher K, Johnson J, Chakroff J, Besner GE. Comparison of Different In Vivo Incubation Sites to Produce Tissue-Engineered Small Intestine. Tissue Eng Part A. 2018 Mar 1;  

                


                  Cromeens BP, Wang Y, Liu Y, Johnson J, Besner GE. Critical intestinal cells originate from the host in enteroid-derived tissue-engineered intestine. J Surg Res. 2018 Mar; 223: 155-164.

                


                  Drucker NA, McCulloh CJ, Li B, Pierro A, Besner GE, Markel TA. Stem cell therapy in necrotizing enterocolitis: Current state and future directions. Semin Pediatr Surg. 2018 Feb; 27: 57-64.

                


                  Nordin AB, Sales SP, Besner GE, Levitt MA, Wood RJ, Kenney BD. Effective methods to decrease surgical site infections in pediatric gastrointestinal surgery. J Pediatr Surg. 2017 Oct 10;  

                


                  Olson JK, Deming LA, King DR, Rager TM, Gartner S, Huibregtse N, Moss RL, Besner GE. Single visit surgery for pediatric ambulatory surgical procedures: a satisfaction and cost analysis. J Pediatr Surg. 2017 Oct 10;  

                


                  Aldrink JH, Gonzalez DO, Sales SP, Deans KJ, Besner GE, Hewitt GD. Using quality improvement methodology to improve ovarian salvage for benign ovarian masses. J Pediatr Surg. 2017 Oct 10;  

                


                  Shen S, Wang H, Xue Y, Yuan L, Zhou X, Zhao Z, Dong E, Liu B, Liu W, Cromeens B, Adler B, Besner G, Xu RX. Freeform fabrication of tissue-simulating phantom for potential use of surgical planning in conjoined twins separation surgery. Sci Rep. 2017 Sep 8; 7: 11048.

                


                  Zhou Y, Wang Y, Olson J, Yang J, Besner GE. Heparin-binding EGF-like growth factor promotes neuronal nitric oxide synthase expression and protects the enteric nervous system after necrotizing enterocolitis. Pediatr Res. 2017 Sep; 82: 490-500.

                


                  Cromeens BP, Ray WC, Hoehne B, Abayneh F, Adler B, Besner GE. Facilitating surgeon understanding of complex anatomy using a three-dimensional printed model. J Surg Res. 2017 Aug; 216: 18-25.

                


                  McCulloh CJ, Olson JK, Wang Y, Vu J, Gartner S, Besner GE. Evaluating the efficacy of different types of stem cells in preserving gut barrier function in necrotizing enterocolitis. J Surg Res. 2017 Jun 15; 214: 278-285.

                


                  McCulloh CJ, Olson JK, Zhou Y, Wang Y, Besner GE. Stem cells and necrotizing enterocolitis: A direct comparison of the efficacy of multiple types of stem cells. J Pediatr Surg. 2017 Jun; 52: 999-1005.

                


                  Cromeens BP, Lisciandro RE, Brilli RJ, Askegard-Giesmann JR, Kenney BD, Besner GE. Identifying Adverse Events in Pediatric Surgery: Comparing Morbidity and Mortality Conference with the NSQIP-Pediatric System. J Am Coll Surg. 2017 May; 224: 945-953.

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 11/26/1991

Board Certifications

Pediatric Surgery Surgery Surgical Critical Care

Fellowship

Boston Children’s Hospital

Date Completed: 06/30/1989

Residency

Children’s Hospital of Buffalo

Date Completed: 06/30/1991

Residency

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1987

Internship

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1983

Medical School

University of Cincinnati

Date Completed: 06/13/1982

Research Funding

National Institutes of Health Exosomes and HB-EGF in Stem Cell-Mediated Therapy for Necrotizing Enterocolitis, Principal Investigator National Institutes of Health Tuneable Native Probiotic Formulations to Study and Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI) National Institutes of Health Tissue Engineered Intestine, Co-Principal Investigator National Institutes of Health A Novel Probiotic Platform to Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI)

Contact Information

General Pediatric Surgery

Call us at: (614) 722-3900

Fax us at: (614) 722-3903

                    Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-3900

Fax us at: (614) 722-3903

General Pediatric SurgeryPediatric Surgery700 Children’s DrColumbus, OH 43205 (map)

Learn more about Gail E. Besner

Biography

Gail E. Besner, MD, is Chief of Pediatric Surgery at Nationwide Children’s Hospital. She is also a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital and Associate Program Director of the Pediatric Surgery Residency program. She also holds the H. William Clatworthy Jr. Professorship in Surgery at The Ohio State University College of Medicine and is a Professor of Surgery and Pediatrics at The Ohio State University College of Medicine. Dr. Besner’s clinical interests include neonatal surgery, necrotizing enterocolitis, and pediatric burn care. Her research interests involve the identification of novel strategies to protect the intestines from injury using growth factors and stem cells, as well as the production of tissue engineered intestine. Dr. Besner’s research has been continually funded by grants from the National Institutes of Health for over two decades. Dr. Besner is currently serving a 4-year term as a member of the National Institute of General Medical Sciences Advisory Council of the National Institutes of Health.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Nationwide Children’s Hospital Toledo

Academic and Clinical Areas

Pediatric Surgery

Chief

Surgical Services

Service Line Chief

Pediatric Surgery Residency

Associate Program Director

Trauma

Surgeon Team

Neonatology

Principal Investigator

Center for Perinatal Research

Principal Investigator

Pediatric Colorectal Research Fellowship

Faculty

Surgical Critical Care Fellowship

Faculty

Primary Department

General Pediatric Surgery

Awards, Honors & Organizations

Research Award, Platinum First Place Award Winner - Resident’s Paper Competition (RS), Presidential Symposium, Columbus Surgical Society, 2018 Researcher Spotlight Journal Recognition, 2018 Oral Presentation Research Award, Third Place Award (RS), The Ohio State University Department of Surgery Research Day, 2018 Advocate in Medicine Award, Ethiopian Tewahedo Social Services (ETSS), 2017 Outstanding Resident Presentation Award (CM), Association of Academic Surgery, 2017 Research Award, Gold Medal Winner - Resident’s Paper Competition (CM), Presidential Symposium, Columbus Surgical Society, 2017 Best Poster Award, First Place Award – Resident’s Poster Competition (JO), Center for Regenerative Medicine and Cell Based Therapies 10th Annual Regenerative Medicine and Wound Care Conference, 2017 Best Poster Award, Bronze Prize Winner – Research Scientist Poster Competition (YZ), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, 2017 Quality Award for Value in Surgery (AN), American Pediatric Surgical Association Meeting, 2017 Best Oral Presentation Award, First Place Award (BC), Vidant Medical Center Medical Staff Graduate Medical Education Research Day, East Carolina State University, 2017 Oral Presentation Research Award, Second Place Award (CM), The Ohio State University Department of Surgery Research Day, 2017 Summer Student Poster Presentation Award, First Place College Student Award (SD), The Research Institute at Nationwide Children’s Hospital Summer Student Poster Competition, 2017 Spring Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital, 2016 Fall Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital (CM), 2016 Research Poster Award, First Place Poster Award (SG), The Research Institute at Nationwide Children’s Hospital, Student Research Symposium, Columbus, Ohio, 2016 Rosencrantz Resident Research Award, Best Basic Science Research Presentation Award (CM), American Academy of Pediatrics Section on Surgery, 2016 Best Manuscript by a New AAS Member, Academic Surgical Conference, 2016 Research Award, Oral Presentation (YW), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016 Best Poster Award, Bronze Prize Winner – Resident’s Poster Competition (BC), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, Columbus, Ohio, 2016 Medical Student Travel Award, The Ohio State University College of Medicine (SG), 2016 Excellence in Innovation Award Recipient, “HB-EGF for Use in Methods of Treating and Preventing Intestinal Injury Related to Hemorrhagic Shock and Resusc, The Research Institute at Nationwide Children’s Hospital, 2016 Third Place Prize Winner – Student Research Competition (SG), Pediatric Medical Student Research Forum, Orlando, FL, 2016 Research Award - First Place Research Poster Award, Clinical Fellow Category (JO), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016 Research Award, Platinum Prize Winner - Resident’s Paper Competition (JO), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016 Research Award, Bronze Prize Winner - Resident’s Paper Competition (BC), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016 Research Award, First Place Basic Science Poster Award (DM), Association of Indian Physicians of Northern Ohio Annual Research Symposium, Cleveland, OH, 2016 Career Contribution Award Recipient, Nationwide Children’s Hospital, 2012 Listed, Best Doctors in America

Research

Lab(s)

Center for Perinatal Research

Dr. Gail Besner’s primary research began in 1990 with the identification of the growth factor “heparin-binding EGF-like growth factor” (HB-EGF). The long range goal of this research is determine whether or not HB-EGF could be used in therapies to protect and treat intestinal damage in high-risk neonates. Her studies have shown that HB-EGF’s anti-inflammatory effects and chemical properties play a vital role in the regenerating of intestinal cells after they have been damaged. Lab research has shown that HB-EGF can protect the intestine from damage caused by hemorrhagic shock, blood supply restriction and necrotizing enterocolitis. Clinical studies are on the horizon to further test HB-EGF as a treatment option. Publications

                  Ettinger NA, Hill VL, Russ CM, Rakoczy KJ, Fallat ME, Wright TN, Choong K, Agus MSD, Hsu B, SECTION ON CRITICAL CARE, COMMITTEE ON HOSPITAL CARE, SECTION ON SURGERY., Mack E, Day S, Lowrie L, Siegel L, Srinivasan V, Gadepalli S, Hirshberg EL, Kissoon N, October T, Tamburro RF, Rotta A, Tellez S, Rauch DA, Ernst K, Vinocur C, Lam VT, Romito B, Hanson N, Gigli KH, Mauro M, Leonard MS, Alexander SN, Davidoff A, Besner GE, Browne M, Downard CD, Gow KW, Islam S, Saunders Walsh D, Williams RF, Thorne V. Guidance for Structuring a Pediatric Intermediate Care Unit. Pediatrics. 2022 May 1; 149: 

                


                  Dunn M, Savoie K, Erdem G, Dykes MW, Buckingham D, Spencer S, Besner G, Kenney B. Quality improvement methodology can reduce hospitalisation for abscess management. Emerg Med J. 2022 Jan 11;  

                


                  Ragan MV, Wala SJ, Goodman SD, Bailey MT, Besner GE. Next-Generation Probiotic Therapy to Protect the Intestines From Injury. Front Cell Infect Microbiol. 2022; 12: 863949.

                


                  Galley JD, Mar P, Wang Y, Han R, Rajab A, Besner GE. Urine-derived extracellular vesicle miRNAs as possible biomarkers for and mediators of necrotizing enterocolitis: A proof of concept study. J Pediatr Surg. 2021 Nov; 56: 1966-1975.

                


                  Blakely ML, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK, Besner GE, Das A, Ohls RK, Truog WE, Nelin LD, Poindexter BB, Pedroza C, Walsh MC, Stoll BJ, Geller R, Kennedy KA, Dimmitt RA, Carlo WA, Cotten CM, Laptook AR, Van Meurs KP, Calkins KL, Sokol GM, Sanchez PJ, Wyckoff MH, Patel RM, Frantz ID 3rd, Shankaran S, D'Angio CT, Yoder BA, Bell EF, Watterberg KL, Martin CA, Harmon CM, Rice H, Kurkchubasche AG, Sylvester K, Dunn JCY, Markel TA, Diesen DL, Bhatia AM, Flake A, Chwals WJ, Brown R, Bass KD, St Peter SD, Shanti CM, Pegoli W Jr, Skarda D, Shilyansky J, Lemon DG, Mosquera RA, Peralta-Carcelen M, Goldstein RF, Vohr BR, Purdy IB, Hines AC, Maitre NL, Heyne RJ, DeMauro SB, McGowan EC, Yolton K, Kilbride HW, Natarajan G, Yost K, Winter S, Colaizy TT, Laughon MM, Lakshminrusimha S, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network.. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial. Ann Surg. 2021 Oct 1; 274: e370-e380.

                


                  Shelby RD, Mar P, Janzow GE, Mashburn-Warren L, Tengberg N, Navarro JB, Allen JM, Wickham J, Wang Y, Bailey MT, Goodman SD, Besner GE. Antibacterial and anti-inflammatory effects of Lactobacillus reuteri in its biofilm state contribute to its beneficial effects in a rat model of experimental necrotizing enterocolitis. J Pediatr Surg. 2021 Sep 20;  

                


                  Brigstock NM, Besner GE. Development of an academic RVU (aRVU) system to promote pediatric surgical academic productivity. J Pediatr Surg. 2021 Sep 20;  

                


                  Wang Y, Jaggers RM, Mar P, Galley JD, Shaffer T, Rajab A, Deshpande S, Mashburn-Warren L, Buzzo JR, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in its biofilm state promotes neurodevelopment after experimental necrotizing enterocolitis in rats. Brain Behav Immun Health. 2021 Jul; 14: 

                


                  Al-Hadidi A, Navarro J, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in Its Biofilm State Improves Protection from Experimental Necrotizing Enterocolitis. Nutrients. 2021 Mar 12; 13: 

                


                  Lawrence AE, Huntington JT, Savoie K, Dykes M, Aldrink JH, Richards H, Besner GE, Kenney B, Fisher J, Minneci PC, Michalsky MP. Improving care through standardized treatment of spontaneous pneumothorax. J Pediatr Surg. 2021 Jan; 56: 55-60.

                


                  Nitkin CR, Rajasingh J, Pisano C, Besner GE, Thébaud B, Sampath V. Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Pediatr Res. 2020 Jan; 87: 265-276.

                


                  Pisano C, Galley J, Elbahrawy M, Wang Y, Farrell A, Brigstock D, Besner GE. Human Breast Milk-Derived Extracellular Vesicles in the Protection Against Experimental Necrotizing Enterocolitis. J Pediatr Surg. 2020 Jan; 55: 54-58.

                


                  Savoie KB, Shelby RD, Dykes MW, Diefenbach KA, Besner GE, Kenney BD. Volume of Irrigation Does Not Affect Rate of Abscess in Perforated Appendicitis. J Laparoendosc Adv Surg Tech A. 2019 Oct; 29: 1232-1238.

                


                  Shelby RD, Tengberg N, Conces M, Olson JK, Navarro JB, Bailey MT, Goodman SD, Besner GE. Development of a Standardized Scoring System to Assess a Murine Model of Clostridium difficile Colitis. J Invest Surg. 2019 Mar 20;  1-9.

                


                  Shelby RD, Cromeens B, Rager TM, Besner GE. Influence of Growth Factors on the Development of Necrotizing Enterocolitis. Clin Perinatol. 2019 Mar; 46: 51-64.

                


                  Perrone EE, Olson J, Golden JM, Besner GE, Gayer CP, Islam S, Gollin G. Closing gastroschisis: The good, the bad, and the not-so ugly. J Pediatr Surg. 2019 Jan; 54: 60-64.

                


                  Nordin AB, Diefenbach K, Sales SP, Christensen J, Besner GE, Kenney BD. Gangrenous appendicitis: No longer complicated. J Pediatr Surg. 2018 Nov 6;  

                


                  Liu Y, Wang Y, Chakroff J, Johnson J, Farrell A, Besner GE. Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors. Tissue Eng Part A. 2018 Oct 4;  

                


                  Pisano C, Besner GE. Potential role of stem cells in disease prevention based on a murine model of experimental necrotizing enterocolitis. J Pediatr Surg. 2018 Sep 5;  

                


                  Olson JK, Navarro JB, Allen JM, McCulloh CJ, Mashburn-Warren L, Wang Y, Varaljay VA, Bailey MT, Goodman SD, Besner GE. An enhanced Lactobacillus reuteri biofilm formulation that increases protection against experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2018 Sep 1; 315: G408-G419.

                


                  Liu Y, Nelson T, Chakroff J, Cromeens B, Johnson J, Lannutti J, Besner GE. Comparison of polyglycolic acid, polycaprolactone, and collagen as scaffolds for the production of tissue engineered intestine. J Biomed Mater Res B Appl Biomater. 2018 Sep 30;  

                


                  McCulloh CJ, Olson JK, Wang Y, Zhou Y, Tengberg NH, Deshpande S, Besner GE. Treatment of experimental necrotizing enterocolitis with stem cell-derived exosomes. J Pediatr Surg. 2018 Jun; 53: 1215-1220.

                


                  Liu Y, Cromeens BP, Wang Y, Fisher K, Johnson J, Chakroff J, Besner GE. Comparison of Different In Vivo Incubation Sites to Produce Tissue-Engineered Small Intestine. Tissue Eng Part A. 2018 Mar 1;  

                


                  Cromeens BP, Wang Y, Liu Y, Johnson J, Besner GE. Critical intestinal cells originate from the host in enteroid-derived tissue-engineered intestine. J Surg Res. 2018 Mar; 223: 155-164.

                


                  Drucker NA, McCulloh CJ, Li B, Pierro A, Besner GE, Markel TA. Stem cell therapy in necrotizing enterocolitis: Current state and future directions. Semin Pediatr Surg. 2018 Feb; 27: 57-64.

                


                  Nordin AB, Sales SP, Besner GE, Levitt MA, Wood RJ, Kenney BD. Effective methods to decrease surgical site infections in pediatric gastrointestinal surgery. J Pediatr Surg. 2017 Oct 10;  

                


                  Olson JK, Deming LA, King DR, Rager TM, Gartner S, Huibregtse N, Moss RL, Besner GE. Single visit surgery for pediatric ambulatory surgical procedures: a satisfaction and cost analysis. J Pediatr Surg. 2017 Oct 10;  

                


                  Aldrink JH, Gonzalez DO, Sales SP, Deans KJ, Besner GE, Hewitt GD. Using quality improvement methodology to improve ovarian salvage for benign ovarian masses. J Pediatr Surg. 2017 Oct 10;  

                


                  Shen S, Wang H, Xue Y, Yuan L, Zhou X, Zhao Z, Dong E, Liu B, Liu W, Cromeens B, Adler B, Besner G, Xu RX. Freeform fabrication of tissue-simulating phantom for potential use of surgical planning in conjoined twins separation surgery. Sci Rep. 2017 Sep 8; 7: 11048.

                


                  Zhou Y, Wang Y, Olson J, Yang J, Besner GE. Heparin-binding EGF-like growth factor promotes neuronal nitric oxide synthase expression and protects the enteric nervous system after necrotizing enterocolitis. Pediatr Res. 2017 Sep; 82: 490-500.

                


                  Cromeens BP, Ray WC, Hoehne B, Abayneh F, Adler B, Besner GE. Facilitating surgeon understanding of complex anatomy using a three-dimensional printed model. J Surg Res. 2017 Aug; 216: 18-25.

                


                  McCulloh CJ, Olson JK, Wang Y, Vu J, Gartner S, Besner GE. Evaluating the efficacy of different types of stem cells in preserving gut barrier function in necrotizing enterocolitis. J Surg Res. 2017 Jun 15; 214: 278-285.

                


                  McCulloh CJ, Olson JK, Zhou Y, Wang Y, Besner GE. Stem cells and necrotizing enterocolitis: A direct comparison of the efficacy of multiple types of stem cells. J Pediatr Surg. 2017 Jun; 52: 999-1005.

                


                  Cromeens BP, Lisciandro RE, Brilli RJ, Askegard-Giesmann JR, Kenney BD, Besner GE. Identifying Adverse Events in Pediatric Surgery: Comparing Morbidity and Mortality Conference with the NSQIP-Pediatric System. J Am Coll Surg. 2017 May; 224: 945-953.

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 11/26/1991

Board Certifications

Pediatric Surgery Surgery Surgical Critical Care

Fellowship

Boston Children’s Hospital

Date Completed: 06/30/1989

Residency

Children’s Hospital of Buffalo

Date Completed: 06/30/1991

Residency

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1987

Internship

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1983

Medical School

University of Cincinnati

Date Completed: 06/13/1982

Research Funding

National Institutes of Health Exosomes and HB-EGF in Stem Cell-Mediated Therapy for Necrotizing Enterocolitis, Principal Investigator National Institutes of Health Tuneable Native Probiotic Formulations to Study and Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI) National Institutes of Health Tissue Engineered Intestine, Co-Principal Investigator National Institutes of Health A Novel Probiotic Platform to Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI)

Contact Information

General Pediatric Surgery

Call us at: (614) 722-3900

Fax us at: (614) 722-3903

                    Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-3900

Fax us at: (614) 722-3903

General Pediatric SurgeryPediatric Surgery700 Children’s DrColumbus, OH 43205 (map)

Learn more about Gail E. Besner

Contact Information

  • Call us at:
  • (614) 722-3900
  • Fax us at:
  • (614) 722-3903
  • General Pediatric SurgeryPediatric Surgery700 Children’s DrColumbus, OH 43205 (map)

Learn more about Gail E. Besner

Biography

Gail E. Besner, MD, is Chief of Pediatric Surgery at Nationwide Children’s Hospital. She is also a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital and Associate Program Director of the Pediatric Surgery Residency program. She also holds the H. William Clatworthy Jr. Professorship in Surgery at The Ohio State University College of Medicine and is a Professor of Surgery and Pediatrics at The Ohio State University College of Medicine. Dr. Besner’s clinical interests include neonatal surgery, necrotizing enterocolitis, and pediatric burn care. Her research interests involve the identification of novel strategies to protect the intestines from injury using growth factors and stem cells, as well as the production of tissue engineered intestine. Dr. Besner’s research has been continually funded by grants from the National Institutes of Health for over two decades. Dr. Besner is currently serving a 4-year term as a member of the National Institute of General Medical Sciences Advisory Council of the National Institutes of Health.

Biography

Gail E. Besner, MD, is Chief of Pediatric Surgery at Nationwide Children’s Hospital. She is also a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital and Associate Program Director of the Pediatric Surgery Residency program. She also holds the H. William Clatworthy Jr. Professorship in Surgery at The Ohio State University College of Medicine and is a Professor of Surgery and Pediatrics at The Ohio State University College of Medicine. Dr. Besner’s clinical interests include neonatal surgery, necrotizing enterocolitis, and pediatric burn care. Her research interests involve the identification of novel strategies to protect the intestines from injury using growth factors and stem cells, as well as the production of tissue engineered intestine. Dr. Besner’s research has been continually funded by grants from the National Institutes of Health for over two decades. Dr. Besner is currently serving a 4-year term as a member of the National Institute of General Medical Sciences Advisory Council of the National Institutes of Health.

Biography

Gail E. Besner, MD, is Chief of Pediatric Surgery at Nationwide Children’s Hospital. She is also a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital and Associate Program Director of the Pediatric Surgery Residency program. She also holds the H. William Clatworthy Jr. Professorship in Surgery at The Ohio State University College of Medicine and is a Professor of Surgery and Pediatrics at The Ohio State University College of Medicine. Dr. Besner’s clinical interests include neonatal surgery, necrotizing enterocolitis, and pediatric burn care. Her research interests involve the identification of novel strategies to protect the intestines from injury using growth factors and stem cells, as well as the production of tissue engineered intestine. Dr. Besner’s research has been continually funded by grants from the National Institutes of Health for over two decades. Dr. Besner is currently serving a 4-year term as a member of the National Institute of General Medical Sciences Advisory Council of the National Institutes of Health.

Gail E. Besner, MD, is Chief of Pediatric Surgery at Nationwide Children’s Hospital. She is also a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital and Associate Program Director of the Pediatric Surgery Residency program. She also holds the H. William Clatworthy Jr. Professorship in Surgery at The Ohio State University College of Medicine and is a Professor of Surgery and Pediatrics at The Ohio State University College of Medicine. Dr. Besner’s clinical interests include neonatal surgery, necrotizing enterocolitis, and pediatric burn care. Her research interests involve the identification of novel strategies to protect the intestines from injury using growth factors and stem cells, as well as the production of tissue engineered intestine. Dr. Besner’s research has been continually funded by grants from the National Institutes of Health for over two decades. Dr. Besner is currently serving a 4-year term as a member of the National Institute of General Medical Sciences Advisory Council of the National Institutes of Health.

Gail E. Besner, MD, is Chief of Pediatric Surgery at Nationwide Children’s Hospital. She is also a Principal Investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital and Associate Program Director of the Pediatric Surgery Residency program. She also holds the H. William Clatworthy Jr. Professorship in Surgery at The Ohio State University College of Medicine and is a Professor of Surgery and Pediatrics at The Ohio State University College of Medicine.

Dr. Besner’s clinical interests include neonatal surgery, necrotizing enterocolitis, and pediatric burn care. Her research interests involve the identification of novel strategies to protect the intestines from injury using growth factors and stem cells, as well as the production of tissue engineered intestine. Dr. Besner’s research has been continually funded by grants from the National Institutes of Health for over two decades. Dr. Besner is currently serving a 4-year term as a member of the National Institute of General Medical Sciences Advisory Council of the National Institutes of Health.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Nationwide Children’s Hospital Toledo

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Nationwide Children’s Hospital Toledo

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Nationwide Children’s Hospital Toledo

Locations

Main Campus of Nationwide Children’s Hospital

Nationwide Children’s Hospital Toledo

Locations

Main Campus of Nationwide Children’s Hospital

Nationwide Children’s Hospital Toledo

Locations

Main Campus of Nationwide Children’s Hospital

Nationwide Children’s Hospital Toledo

  • Main Campus of Nationwide Children’s Hospital
  • Nationwide Children’s Hospital Toledo

Academic and Clinical Areas

Pediatric Surgery

Chief

Surgical Services

Service Line Chief

Pediatric Surgery Residency

Associate Program Director

Trauma

Surgeon Team

Neonatology

Principal Investigator

Center for Perinatal Research

Principal Investigator

Pediatric Colorectal Research Fellowship

Faculty

Surgical Critical Care Fellowship

Faculty

Primary Department

General Pediatric Surgery

Academic and Clinical Areas

Pediatric Surgery

Chief

Surgical Services

Service Line Chief

Pediatric Surgery Residency

Associate Program Director

Trauma

Surgeon Team

Neonatology

Principal Investigator

Center for Perinatal Research

Principal Investigator

Pediatric Colorectal Research Fellowship

Faculty

Surgical Critical Care Fellowship

Faculty

Primary Department

General Pediatric Surgery

Academic and Clinical Areas

Pediatric Surgery

Chief

Surgical Services

Service Line Chief

Pediatric Surgery Residency

Associate Program Director

Trauma

Surgeon Team

Neonatology

Principal Investigator

Center for Perinatal Research

Principal Investigator

Pediatric Colorectal Research Fellowship

Faculty

Surgical Critical Care Fellowship

Faculty

Primary Department

General Pediatric Surgery

Pediatric Surgery

Chief

Surgical Services

Service Line Chief

Pediatric Surgery Residency

Associate Program Director

Trauma

Surgeon Team

Neonatology

Principal Investigator

Center for Perinatal Research

Principal Investigator

Pediatric Colorectal Research Fellowship

Faculty

Surgical Critical Care Fellowship

Faculty

Primary Department

General Pediatric Surgery

  • Pediatric Surgery
  • Chief
  • Surgical Services
  • Service Line Chief
  • Pediatric Surgery Residency
  • Associate Program Director
  • Trauma
  • Surgeon Team
  • Neonatology
  • Principal Investigator
  • Center for Perinatal Research
  • Principal Investigator
  • Pediatric Colorectal Research Fellowship
  • Faculty
  • Surgical Critical Care Fellowship
  • Faculty
  • Primary Department
  • General Pediatric Surgery

Awards, Honors & Organizations

Research Award, Platinum First Place Award Winner - Resident’s Paper Competition (RS), Presidential Symposium, Columbus Surgical Society, 2018 Researcher Spotlight Journal Recognition, 2018 Oral Presentation Research Award, Third Place Award (RS), The Ohio State University Department of Surgery Research Day, 2018 Advocate in Medicine Award, Ethiopian Tewahedo Social Services (ETSS), 2017 Outstanding Resident Presentation Award (CM), Association of Academic Surgery, 2017 Research Award, Gold Medal Winner - Resident’s Paper Competition (CM), Presidential Symposium, Columbus Surgical Society, 2017 Best Poster Award, First Place Award – Resident’s Poster Competition (JO), Center for Regenerative Medicine and Cell Based Therapies 10th Annual Regenerative Medicine and Wound Care Conference, 2017 Best Poster Award, Bronze Prize Winner – Research Scientist Poster Competition (YZ), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, 2017 Quality Award for Value in Surgery (AN), American Pediatric Surgical Association Meeting, 2017 Best Oral Presentation Award, First Place Award (BC), Vidant Medical Center Medical Staff Graduate Medical Education Research Day, East Carolina State University, 2017 Oral Presentation Research Award, Second Place Award (CM), The Ohio State University Department of Surgery Research Day, 2017 Summer Student Poster Presentation Award, First Place College Student Award (SD), The Research Institute at Nationwide Children’s Hospital Summer Student Poster Competition, 2017 Spring Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital, 2016 Fall Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital (CM), 2016 Research Poster Award, First Place Poster Award (SG), The Research Institute at Nationwide Children’s Hospital, Student Research Symposium, Columbus, Ohio, 2016 Rosencrantz Resident Research Award, Best Basic Science Research Presentation Award (CM), American Academy of Pediatrics Section on Surgery, 2016 Best Manuscript by a New AAS Member, Academic Surgical Conference, 2016 Research Award, Oral Presentation (YW), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016 Best Poster Award, Bronze Prize Winner – Resident’s Poster Competition (BC), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, Columbus, Ohio, 2016 Medical Student Travel Award, The Ohio State University College of Medicine (SG), 2016 Excellence in Innovation Award Recipient, “HB-EGF for Use in Methods of Treating and Preventing Intestinal Injury Related to Hemorrhagic Shock and Resusc, The Research Institute at Nationwide Children’s Hospital, 2016 Third Place Prize Winner – Student Research Competition (SG), Pediatric Medical Student Research Forum, Orlando, FL, 2016 Research Award - First Place Research Poster Award, Clinical Fellow Category (JO), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016 Research Award, Platinum Prize Winner - Resident’s Paper Competition (JO), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016 Research Award, Bronze Prize Winner - Resident’s Paper Competition (BC), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016 Research Award, First Place Basic Science Poster Award (DM), Association of Indian Physicians of Northern Ohio Annual Research Symposium, Cleveland, OH, 2016 Career Contribution Award Recipient, Nationwide Children’s Hospital, 2012 Listed, Best Doctors in America

Awards, Honors & Organizations

Research Award, Platinum First Place Award Winner - Resident’s Paper Competition (RS), Presidential Symposium, Columbus Surgical Society, 2018 Researcher Spotlight Journal Recognition, 2018 Oral Presentation Research Award, Third Place Award (RS), The Ohio State University Department of Surgery Research Day, 2018 Advocate in Medicine Award, Ethiopian Tewahedo Social Services (ETSS), 2017 Outstanding Resident Presentation Award (CM), Association of Academic Surgery, 2017 Research Award, Gold Medal Winner - Resident’s Paper Competition (CM), Presidential Symposium, Columbus Surgical Society, 2017 Best Poster Award, First Place Award – Resident’s Poster Competition (JO), Center for Regenerative Medicine and Cell Based Therapies 10th Annual Regenerative Medicine and Wound Care Conference, 2017 Best Poster Award, Bronze Prize Winner – Research Scientist Poster Competition (YZ), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, 2017 Quality Award for Value in Surgery (AN), American Pediatric Surgical Association Meeting, 2017 Best Oral Presentation Award, First Place Award (BC), Vidant Medical Center Medical Staff Graduate Medical Education Research Day, East Carolina State University, 2017 Oral Presentation Research Award, Second Place Award (CM), The Ohio State University Department of Surgery Research Day, 2017 Summer Student Poster Presentation Award, First Place College Student Award (SD), The Research Institute at Nationwide Children’s Hospital Summer Student Poster Competition, 2017 Spring Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital, 2016 Fall Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital (CM), 2016 Research Poster Award, First Place Poster Award (SG), The Research Institute at Nationwide Children’s Hospital, Student Research Symposium, Columbus, Ohio, 2016 Rosencrantz Resident Research Award, Best Basic Science Research Presentation Award (CM), American Academy of Pediatrics Section on Surgery, 2016 Best Manuscript by a New AAS Member, Academic Surgical Conference, 2016 Research Award, Oral Presentation (YW), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016 Best Poster Award, Bronze Prize Winner – Resident’s Poster Competition (BC), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, Columbus, Ohio, 2016 Medical Student Travel Award, The Ohio State University College of Medicine (SG), 2016 Excellence in Innovation Award Recipient, “HB-EGF for Use in Methods of Treating and Preventing Intestinal Injury Related to Hemorrhagic Shock and Resusc, The Research Institute at Nationwide Children’s Hospital, 2016 Third Place Prize Winner – Student Research Competition (SG), Pediatric Medical Student Research Forum, Orlando, FL, 2016 Research Award - First Place Research Poster Award, Clinical Fellow Category (JO), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016 Research Award, Platinum Prize Winner - Resident’s Paper Competition (JO), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016 Research Award, Bronze Prize Winner - Resident’s Paper Competition (BC), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016 Research Award, First Place Basic Science Poster Award (DM), Association of Indian Physicians of Northern Ohio Annual Research Symposium, Cleveland, OH, 2016 Career Contribution Award Recipient, Nationwide Children’s Hospital, 2012 Listed, Best Doctors in America

Awards, Honors & Organizations

Research Award, Platinum First Place Award Winner - Resident’s Paper Competition (RS), Presidential Symposium, Columbus Surgical Society, 2018 Researcher Spotlight Journal Recognition, 2018 Oral Presentation Research Award, Third Place Award (RS), The Ohio State University Department of Surgery Research Day, 2018 Advocate in Medicine Award, Ethiopian Tewahedo Social Services (ETSS), 2017 Outstanding Resident Presentation Award (CM), Association of Academic Surgery, 2017 Research Award, Gold Medal Winner - Resident’s Paper Competition (CM), Presidential Symposium, Columbus Surgical Society, 2017 Best Poster Award, First Place Award – Resident’s Poster Competition (JO), Center for Regenerative Medicine and Cell Based Therapies 10th Annual Regenerative Medicine and Wound Care Conference, 2017 Best Poster Award, Bronze Prize Winner – Research Scientist Poster Competition (YZ), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, 2017 Quality Award for Value in Surgery (AN), American Pediatric Surgical Association Meeting, 2017 Best Oral Presentation Award, First Place Award (BC), Vidant Medical Center Medical Staff Graduate Medical Education Research Day, East Carolina State University, 2017 Oral Presentation Research Award, Second Place Award (CM), The Ohio State University Department of Surgery Research Day, 2017 Summer Student Poster Presentation Award, First Place College Student Award (SD), The Research Institute at Nationwide Children’s Hospital Summer Student Poster Competition, 2017 Spring Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital, 2016 Fall Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital (CM), 2016 Research Poster Award, First Place Poster Award (SG), The Research Institute at Nationwide Children’s Hospital, Student Research Symposium, Columbus, Ohio, 2016 Rosencrantz Resident Research Award, Best Basic Science Research Presentation Award (CM), American Academy of Pediatrics Section on Surgery, 2016 Best Manuscript by a New AAS Member, Academic Surgical Conference, 2016 Research Award, Oral Presentation (YW), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016 Best Poster Award, Bronze Prize Winner – Resident’s Poster Competition (BC), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, Columbus, Ohio, 2016 Medical Student Travel Award, The Ohio State University College of Medicine (SG), 2016 Excellence in Innovation Award Recipient, “HB-EGF for Use in Methods of Treating and Preventing Intestinal Injury Related to Hemorrhagic Shock and Resusc, The Research Institute at Nationwide Children’s Hospital, 2016 Third Place Prize Winner – Student Research Competition (SG), Pediatric Medical Student Research Forum, Orlando, FL, 2016 Research Award - First Place Research Poster Award, Clinical Fellow Category (JO), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016 Research Award, Platinum Prize Winner - Resident’s Paper Competition (JO), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016 Research Award, Bronze Prize Winner - Resident’s Paper Competition (BC), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016 Research Award, First Place Basic Science Poster Award (DM), Association of Indian Physicians of Northern Ohio Annual Research Symposium, Cleveland, OH, 2016 Career Contribution Award Recipient, Nationwide Children’s Hospital, 2012 Listed, Best Doctors in America

Research Award, Platinum First Place Award Winner - Resident’s Paper Competition (RS), Presidential Symposium, Columbus Surgical Society, 2018 Researcher Spotlight Journal Recognition, 2018 Oral Presentation Research Award, Third Place Award (RS), The Ohio State University Department of Surgery Research Day, 2018 Advocate in Medicine Award, Ethiopian Tewahedo Social Services (ETSS), 2017 Outstanding Resident Presentation Award (CM), Association of Academic Surgery, 2017 Research Award, Gold Medal Winner - Resident’s Paper Competition (CM), Presidential Symposium, Columbus Surgical Society, 2017 Best Poster Award, First Place Award – Resident’s Poster Competition (JO), Center for Regenerative Medicine and Cell Based Therapies 10th Annual Regenerative Medicine and Wound Care Conference, 2017 Best Poster Award, Bronze Prize Winner – Research Scientist Poster Competition (YZ), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, 2017 Quality Award for Value in Surgery (AN), American Pediatric Surgical Association Meeting, 2017 Best Oral Presentation Award, First Place Award (BC), Vidant Medical Center Medical Staff Graduate Medical Education Research Day, East Carolina State University, 2017 Oral Presentation Research Award, Second Place Award (CM), The Ohio State University Department of Surgery Research Day, 2017 Summer Student Poster Presentation Award, First Place College Student Award (SD), The Research Institute at Nationwide Children’s Hospital Summer Student Poster Competition, 2017 Spring Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital, 2016 Fall Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital (CM), 2016 Research Poster Award, First Place Poster Award (SG), The Research Institute at Nationwide Children’s Hospital, Student Research Symposium, Columbus, Ohio, 2016 Rosencrantz Resident Research Award, Best Basic Science Research Presentation Award (CM), American Academy of Pediatrics Section on Surgery, 2016 Best Manuscript by a New AAS Member, Academic Surgical Conference, 2016 Research Award, Oral Presentation (YW), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016 Best Poster Award, Bronze Prize Winner – Resident’s Poster Competition (BC), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, Columbus, Ohio, 2016 Medical Student Travel Award, The Ohio State University College of Medicine (SG), 2016 Excellence in Innovation Award Recipient, “HB-EGF for Use in Methods of Treating and Preventing Intestinal Injury Related to Hemorrhagic Shock and Resusc, The Research Institute at Nationwide Children’s Hospital, 2016 Third Place Prize Winner – Student Research Competition (SG), Pediatric Medical Student Research Forum, Orlando, FL, 2016 Research Award - First Place Research Poster Award, Clinical Fellow Category (JO), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016 Research Award, Platinum Prize Winner - Resident’s Paper Competition (JO), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016 Research Award, Bronze Prize Winner - Resident’s Paper Competition (BC), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016 Research Award, First Place Basic Science Poster Award (DM), Association of Indian Physicians of Northern Ohio Annual Research Symposium, Cleveland, OH, 2016 Career Contribution Award Recipient, Nationwide Children’s Hospital, 2012 Listed, Best Doctors in America

  • Research Award, Platinum First Place Award Winner - Resident’s Paper Competition (RS), Presidential Symposium, Columbus Surgical Society, 2018
  • Researcher Spotlight Journal Recognition, 2018
  • Oral Presentation Research Award, Third Place Award (RS), The Ohio State University Department of Surgery Research Day, 2018
  • Advocate in Medicine Award, Ethiopian Tewahedo Social Services (ETSS), 2017
  • Outstanding Resident Presentation Award (CM), Association of Academic Surgery, 2017
  • Research Award, Gold Medal Winner - Resident’s Paper Competition (CM), Presidential Symposium, Columbus Surgical Society, 2017
  • Best Poster Award, First Place Award – Resident’s Poster Competition (JO), Center for Regenerative Medicine and Cell Based Therapies 10th Annual Regenerative Medicine and Wound Care Conference, 2017
  • Best Poster Award, Bronze Prize Winner – Research Scientist Poster Competition (YZ), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, 2017
  • Quality Award for Value in Surgery (AN), American Pediatric Surgical Association Meeting, 2017
  • Best Oral Presentation Award, First Place Award (BC), Vidant Medical Center Medical Staff Graduate Medical Education Research Day, East Carolina State University, 2017
  • Oral Presentation Research Award, Second Place Award (CM), The Ohio State University Department of Surgery Research Day, 2017
  • Summer Student Poster Presentation Award, First Place College Student Award (SD), The Research Institute at Nationwide Children’s Hospital Summer Student Poster Competition, 2017
  • Spring Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital, 2016
  • Fall Trainee Travel Award, The Research Institute at Nationwide Children’s Hospital (CM), 2016
  • Research Poster Award, First Place Poster Award (SG), The Research Institute at Nationwide Children’s Hospital, Student Research Symposium, Columbus, Ohio, 2016
  • Rosencrantz Resident Research Award, Best Basic Science Research Presentation Award (CM), American Academy of Pediatrics Section on Surgery, 2016
  • Best Manuscript by a New AAS Member, Academic Surgical Conference, 2016
  • Research Award, Oral Presentation (YW), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016
  • Best Poster Award, Bronze Prize Winner – Resident’s Poster Competition (BC), Center for Regenerative Medicine and Cell Based Therapies 9th Annual Regenerative Medicine and Wound Care Conference, Columbus, Ohio, 2016
  • Medical Student Travel Award, The Ohio State University College of Medicine (SG), 2016
  • Excellence in Innovation Award Recipient, “HB-EGF for Use in Methods of Treating and Preventing Intestinal Injury Related to Hemorrhagic Shock and Resusc, The Research Institute at Nationwide Children’s Hospital, 2016
  • Third Place Prize Winner – Student Research Competition (SG), Pediatric Medical Student Research Forum, Orlando, FL, 2016
  • Research Award - First Place Research Poster Award, Clinical Fellow Category (JO), The Research Institute at Nationwide Children’s Hospital Research Day, Nationwide Children’s Hospital, 2016
  • Research Award, Platinum Prize Winner - Resident’s Paper Competition (JO), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016
  • Research Award, Bronze Prize Winner - Resident’s Paper Competition (BC), Presidential Symposium, Columbus Surgical Society, Columbus, Ohio, 2016
  • Research Award, First Place Basic Science Poster Award (DM), Association of Indian Physicians of Northern Ohio Annual Research Symposium, Cleveland, OH, 2016
  • Career Contribution Award Recipient, Nationwide Children’s Hospital, 2012
  • Listed, Best Doctors in America

Research

Lab(s)

Center for Perinatal Research

Dr. Gail Besner’s primary research began in 1990 with the identification of the growth factor “heparin-binding EGF-like growth factor” (HB-EGF). The long range goal of this research is determine whether or not HB-EGF could be used in therapies to protect and treat intestinal damage in high-risk neonates. Her studies have shown that HB-EGF’s anti-inflammatory effects and chemical properties play a vital role in the regenerating of intestinal cells after they have been damaged. Lab research has shown that HB-EGF can protect the intestine from damage caused by hemorrhagic shock, blood supply restriction and necrotizing enterocolitis. Clinical studies are on the horizon to further test HB-EGF as a treatment option. Publications

                  Ettinger NA, Hill VL, Russ CM, Rakoczy KJ, Fallat ME, Wright TN, Choong K, Agus MSD, Hsu B, SECTION ON CRITICAL CARE, COMMITTEE ON HOSPITAL CARE, SECTION ON SURGERY., Mack E, Day S, Lowrie L, Siegel L, Srinivasan V, Gadepalli S, Hirshberg EL, Kissoon N, October T, Tamburro RF, Rotta A, Tellez S, Rauch DA, Ernst K, Vinocur C, Lam VT, Romito B, Hanson N, Gigli KH, Mauro M, Leonard MS, Alexander SN, Davidoff A, Besner GE, Browne M, Downard CD, Gow KW, Islam S, Saunders Walsh D, Williams RF, Thorne V. Guidance for Structuring a Pediatric Intermediate Care Unit. Pediatrics. 2022 May 1; 149: 

                


                  Dunn M, Savoie K, Erdem G, Dykes MW, Buckingham D, Spencer S, Besner G, Kenney B. Quality improvement methodology can reduce hospitalisation for abscess management. Emerg Med J. 2022 Jan 11;  

                


                  Ragan MV, Wala SJ, Goodman SD, Bailey MT, Besner GE. Next-Generation Probiotic Therapy to Protect the Intestines From Injury. Front Cell Infect Microbiol. 2022; 12: 863949.

                


                  Galley JD, Mar P, Wang Y, Han R, Rajab A, Besner GE. Urine-derived extracellular vesicle miRNAs as possible biomarkers for and mediators of necrotizing enterocolitis: A proof of concept study. J Pediatr Surg. 2021 Nov; 56: 1966-1975.

                


                  Blakely ML, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK, Besner GE, Das A, Ohls RK, Truog WE, Nelin LD, Poindexter BB, Pedroza C, Walsh MC, Stoll BJ, Geller R, Kennedy KA, Dimmitt RA, Carlo WA, Cotten CM, Laptook AR, Van Meurs KP, Calkins KL, Sokol GM, Sanchez PJ, Wyckoff MH, Patel RM, Frantz ID 3rd, Shankaran S, D'Angio CT, Yoder BA, Bell EF, Watterberg KL, Martin CA, Harmon CM, Rice H, Kurkchubasche AG, Sylvester K, Dunn JCY, Markel TA, Diesen DL, Bhatia AM, Flake A, Chwals WJ, Brown R, Bass KD, St Peter SD, Shanti CM, Pegoli W Jr, Skarda D, Shilyansky J, Lemon DG, Mosquera RA, Peralta-Carcelen M, Goldstein RF, Vohr BR, Purdy IB, Hines AC, Maitre NL, Heyne RJ, DeMauro SB, McGowan EC, Yolton K, Kilbride HW, Natarajan G, Yost K, Winter S, Colaizy TT, Laughon MM, Lakshminrusimha S, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network.. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial. Ann Surg. 2021 Oct 1; 274: e370-e380.

                


                  Shelby RD, Mar P, Janzow GE, Mashburn-Warren L, Tengberg N, Navarro JB, Allen JM, Wickham J, Wang Y, Bailey MT, Goodman SD, Besner GE. Antibacterial and anti-inflammatory effects of Lactobacillus reuteri in its biofilm state contribute to its beneficial effects in a rat model of experimental necrotizing enterocolitis. J Pediatr Surg. 2021 Sep 20;  

                


                  Brigstock NM, Besner GE. Development of an academic RVU (aRVU) system to promote pediatric surgical academic productivity. J Pediatr Surg. 2021 Sep 20;  

                


                  Wang Y, Jaggers RM, Mar P, Galley JD, Shaffer T, Rajab A, Deshpande S, Mashburn-Warren L, Buzzo JR, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in its biofilm state promotes neurodevelopment after experimental necrotizing enterocolitis in rats. Brain Behav Immun Health. 2021 Jul; 14: 

                


                  Al-Hadidi A, Navarro J, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in Its Biofilm State Improves Protection from Experimental Necrotizing Enterocolitis. Nutrients. 2021 Mar 12; 13: 

                


                  Lawrence AE, Huntington JT, Savoie K, Dykes M, Aldrink JH, Richards H, Besner GE, Kenney B, Fisher J, Minneci PC, Michalsky MP. Improving care through standardized treatment of spontaneous pneumothorax. J Pediatr Surg. 2021 Jan; 56: 55-60.

                


                  Nitkin CR, Rajasingh J, Pisano C, Besner GE, Thébaud B, Sampath V. Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Pediatr Res. 2020 Jan; 87: 265-276.

                


                  Pisano C, Galley J, Elbahrawy M, Wang Y, Farrell A, Brigstock D, Besner GE. Human Breast Milk-Derived Extracellular Vesicles in the Protection Against Experimental Necrotizing Enterocolitis. J Pediatr Surg. 2020 Jan; 55: 54-58.

                


                  Savoie KB, Shelby RD, Dykes MW, Diefenbach KA, Besner GE, Kenney BD. Volume of Irrigation Does Not Affect Rate of Abscess in Perforated Appendicitis. J Laparoendosc Adv Surg Tech A. 2019 Oct; 29: 1232-1238.

                


                  Shelby RD, Tengberg N, Conces M, Olson JK, Navarro JB, Bailey MT, Goodman SD, Besner GE. Development of a Standardized Scoring System to Assess a Murine Model of Clostridium difficile Colitis. J Invest Surg. 2019 Mar 20;  1-9.

                


                  Shelby RD, Cromeens B, Rager TM, Besner GE. Influence of Growth Factors on the Development of Necrotizing Enterocolitis. Clin Perinatol. 2019 Mar; 46: 51-64.

                


                  Perrone EE, Olson J, Golden JM, Besner GE, Gayer CP, Islam S, Gollin G. Closing gastroschisis: The good, the bad, and the not-so ugly. J Pediatr Surg. 2019 Jan; 54: 60-64.

                


                  Nordin AB, Diefenbach K, Sales SP, Christensen J, Besner GE, Kenney BD. Gangrenous appendicitis: No longer complicated. J Pediatr Surg. 2018 Nov 6;  

                


                  Liu Y, Wang Y, Chakroff J, Johnson J, Farrell A, Besner GE. Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors. Tissue Eng Part A. 2018 Oct 4;  

                


                  Pisano C, Besner GE. Potential role of stem cells in disease prevention based on a murine model of experimental necrotizing enterocolitis. J Pediatr Surg. 2018 Sep 5;  

                


                  Olson JK, Navarro JB, Allen JM, McCulloh CJ, Mashburn-Warren L, Wang Y, Varaljay VA, Bailey MT, Goodman SD, Besner GE. An enhanced Lactobacillus reuteri biofilm formulation that increases protection against experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2018 Sep 1; 315: G408-G419.

                


                  Liu Y, Nelson T, Chakroff J, Cromeens B, Johnson J, Lannutti J, Besner GE. Comparison of polyglycolic acid, polycaprolactone, and collagen as scaffolds for the production of tissue engineered intestine. J Biomed Mater Res B Appl Biomater. 2018 Sep 30;  

                


                  McCulloh CJ, Olson JK, Wang Y, Zhou Y, Tengberg NH, Deshpande S, Besner GE. Treatment of experimental necrotizing enterocolitis with stem cell-derived exosomes. J Pediatr Surg. 2018 Jun; 53: 1215-1220.

                


                  Liu Y, Cromeens BP, Wang Y, Fisher K, Johnson J, Chakroff J, Besner GE. Comparison of Different In Vivo Incubation Sites to Produce Tissue-Engineered Small Intestine. Tissue Eng Part A. 2018 Mar 1;  

                


                  Cromeens BP, Wang Y, Liu Y, Johnson J, Besner GE. Critical intestinal cells originate from the host in enteroid-derived tissue-engineered intestine. J Surg Res. 2018 Mar; 223: 155-164.

                


                  Drucker NA, McCulloh CJ, Li B, Pierro A, Besner GE, Markel TA. Stem cell therapy in necrotizing enterocolitis: Current state and future directions. Semin Pediatr Surg. 2018 Feb; 27: 57-64.

                


                  Nordin AB, Sales SP, Besner GE, Levitt MA, Wood RJ, Kenney BD. Effective methods to decrease surgical site infections in pediatric gastrointestinal surgery. J Pediatr Surg. 2017 Oct 10;  

                


                  Olson JK, Deming LA, King DR, Rager TM, Gartner S, Huibregtse N, Moss RL, Besner GE. Single visit surgery for pediatric ambulatory surgical procedures: a satisfaction and cost analysis. J Pediatr Surg. 2017 Oct 10;  

                


                  Aldrink JH, Gonzalez DO, Sales SP, Deans KJ, Besner GE, Hewitt GD. Using quality improvement methodology to improve ovarian salvage for benign ovarian masses. J Pediatr Surg. 2017 Oct 10;  

                


                  Shen S, Wang H, Xue Y, Yuan L, Zhou X, Zhao Z, Dong E, Liu B, Liu W, Cromeens B, Adler B, Besner G, Xu RX. Freeform fabrication of tissue-simulating phantom for potential use of surgical planning in conjoined twins separation surgery. Sci Rep. 2017 Sep 8; 7: 11048.

                


                  Zhou Y, Wang Y, Olson J, Yang J, Besner GE. Heparin-binding EGF-like growth factor promotes neuronal nitric oxide synthase expression and protects the enteric nervous system after necrotizing enterocolitis. Pediatr Res. 2017 Sep; 82: 490-500.

                


                  Cromeens BP, Ray WC, Hoehne B, Abayneh F, Adler B, Besner GE. Facilitating surgeon understanding of complex anatomy using a three-dimensional printed model. J Surg Res. 2017 Aug; 216: 18-25.

                


                  McCulloh CJ, Olson JK, Wang Y, Vu J, Gartner S, Besner GE. Evaluating the efficacy of different types of stem cells in preserving gut barrier function in necrotizing enterocolitis. J Surg Res. 2017 Jun 15; 214: 278-285.

                


                  McCulloh CJ, Olson JK, Zhou Y, Wang Y, Besner GE. Stem cells and necrotizing enterocolitis: A direct comparison of the efficacy of multiple types of stem cells. J Pediatr Surg. 2017 Jun; 52: 999-1005.

                


                  Cromeens BP, Lisciandro RE, Brilli RJ, Askegard-Giesmann JR, Kenney BD, Besner GE. Identifying Adverse Events in Pediatric Surgery: Comparing Morbidity and Mortality Conference with the NSQIP-Pediatric System. J Am Coll Surg. 2017 May; 224: 945-953.

View More Publications

Research

Lab(s)

Center for Perinatal Research

Dr. Gail Besner’s primary research began in 1990 with the identification of the growth factor “heparin-binding EGF-like growth factor” (HB-EGF). The long range goal of this research is determine whether or not HB-EGF could be used in therapies to protect and treat intestinal damage in high-risk neonates. Her studies have shown that HB-EGF’s anti-inflammatory effects and chemical properties play a vital role in the regenerating of intestinal cells after they have been damaged. Lab research has shown that HB-EGF can protect the intestine from damage caused by hemorrhagic shock, blood supply restriction and necrotizing enterocolitis. Clinical studies are on the horizon to further test HB-EGF as a treatment option. Publications

                  Ettinger NA, Hill VL, Russ CM, Rakoczy KJ, Fallat ME, Wright TN, Choong K, Agus MSD, Hsu B, SECTION ON CRITICAL CARE, COMMITTEE ON HOSPITAL CARE, SECTION ON SURGERY., Mack E, Day S, Lowrie L, Siegel L, Srinivasan V, Gadepalli S, Hirshberg EL, Kissoon N, October T, Tamburro RF, Rotta A, Tellez S, Rauch DA, Ernst K, Vinocur C, Lam VT, Romito B, Hanson N, Gigli KH, Mauro M, Leonard MS, Alexander SN, Davidoff A, Besner GE, Browne M, Downard CD, Gow KW, Islam S, Saunders Walsh D, Williams RF, Thorne V. Guidance for Structuring a Pediatric Intermediate Care Unit. Pediatrics. 2022 May 1; 149: 

                


                  Dunn M, Savoie K, Erdem G, Dykes MW, Buckingham D, Spencer S, Besner G, Kenney B. Quality improvement methodology can reduce hospitalisation for abscess management. Emerg Med J. 2022 Jan 11;  

                


                  Ragan MV, Wala SJ, Goodman SD, Bailey MT, Besner GE. Next-Generation Probiotic Therapy to Protect the Intestines From Injury. Front Cell Infect Microbiol. 2022; 12: 863949.

                


                  Galley JD, Mar P, Wang Y, Han R, Rajab A, Besner GE. Urine-derived extracellular vesicle miRNAs as possible biomarkers for and mediators of necrotizing enterocolitis: A proof of concept study. J Pediatr Surg. 2021 Nov; 56: 1966-1975.

                


                  Blakely ML, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK, Besner GE, Das A, Ohls RK, Truog WE, Nelin LD, Poindexter BB, Pedroza C, Walsh MC, Stoll BJ, Geller R, Kennedy KA, Dimmitt RA, Carlo WA, Cotten CM, Laptook AR, Van Meurs KP, Calkins KL, Sokol GM, Sanchez PJ, Wyckoff MH, Patel RM, Frantz ID 3rd, Shankaran S, D'Angio CT, Yoder BA, Bell EF, Watterberg KL, Martin CA, Harmon CM, Rice H, Kurkchubasche AG, Sylvester K, Dunn JCY, Markel TA, Diesen DL, Bhatia AM, Flake A, Chwals WJ, Brown R, Bass KD, St Peter SD, Shanti CM, Pegoli W Jr, Skarda D, Shilyansky J, Lemon DG, Mosquera RA, Peralta-Carcelen M, Goldstein RF, Vohr BR, Purdy IB, Hines AC, Maitre NL, Heyne RJ, DeMauro SB, McGowan EC, Yolton K, Kilbride HW, Natarajan G, Yost K, Winter S, Colaizy TT, Laughon MM, Lakshminrusimha S, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network.. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial. Ann Surg. 2021 Oct 1; 274: e370-e380.

                


                  Shelby RD, Mar P, Janzow GE, Mashburn-Warren L, Tengberg N, Navarro JB, Allen JM, Wickham J, Wang Y, Bailey MT, Goodman SD, Besner GE. Antibacterial and anti-inflammatory effects of Lactobacillus reuteri in its biofilm state contribute to its beneficial effects in a rat model of experimental necrotizing enterocolitis. J Pediatr Surg. 2021 Sep 20;  

                


                  Brigstock NM, Besner GE. Development of an academic RVU (aRVU) system to promote pediatric surgical academic productivity. J Pediatr Surg. 2021 Sep 20;  

                


                  Wang Y, Jaggers RM, Mar P, Galley JD, Shaffer T, Rajab A, Deshpande S, Mashburn-Warren L, Buzzo JR, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in its biofilm state promotes neurodevelopment after experimental necrotizing enterocolitis in rats. Brain Behav Immun Health. 2021 Jul; 14: 

                


                  Al-Hadidi A, Navarro J, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in Its Biofilm State Improves Protection from Experimental Necrotizing Enterocolitis. Nutrients. 2021 Mar 12; 13: 

                


                  Lawrence AE, Huntington JT, Savoie K, Dykes M, Aldrink JH, Richards H, Besner GE, Kenney B, Fisher J, Minneci PC, Michalsky MP. Improving care through standardized treatment of spontaneous pneumothorax. J Pediatr Surg. 2021 Jan; 56: 55-60.

                


                  Nitkin CR, Rajasingh J, Pisano C, Besner GE, Thébaud B, Sampath V. Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Pediatr Res. 2020 Jan; 87: 265-276.

                


                  Pisano C, Galley J, Elbahrawy M, Wang Y, Farrell A, Brigstock D, Besner GE. Human Breast Milk-Derived Extracellular Vesicles in the Protection Against Experimental Necrotizing Enterocolitis. J Pediatr Surg. 2020 Jan; 55: 54-58.

                


                  Savoie KB, Shelby RD, Dykes MW, Diefenbach KA, Besner GE, Kenney BD. Volume of Irrigation Does Not Affect Rate of Abscess in Perforated Appendicitis. J Laparoendosc Adv Surg Tech A. 2019 Oct; 29: 1232-1238.

                


                  Shelby RD, Tengberg N, Conces M, Olson JK, Navarro JB, Bailey MT, Goodman SD, Besner GE. Development of a Standardized Scoring System to Assess a Murine Model of Clostridium difficile Colitis. J Invest Surg. 2019 Mar 20;  1-9.

                


                  Shelby RD, Cromeens B, Rager TM, Besner GE. Influence of Growth Factors on the Development of Necrotizing Enterocolitis. Clin Perinatol. 2019 Mar; 46: 51-64.

                


                  Perrone EE, Olson J, Golden JM, Besner GE, Gayer CP, Islam S, Gollin G. Closing gastroschisis: The good, the bad, and the not-so ugly. J Pediatr Surg. 2019 Jan; 54: 60-64.

                


                  Nordin AB, Diefenbach K, Sales SP, Christensen J, Besner GE, Kenney BD. Gangrenous appendicitis: No longer complicated. J Pediatr Surg. 2018 Nov 6;  

                


                  Liu Y, Wang Y, Chakroff J, Johnson J, Farrell A, Besner GE. Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors. Tissue Eng Part A. 2018 Oct 4;  

                


                  Pisano C, Besner GE. Potential role of stem cells in disease prevention based on a murine model of experimental necrotizing enterocolitis. J Pediatr Surg. 2018 Sep 5;  

                


                  Olson JK, Navarro JB, Allen JM, McCulloh CJ, Mashburn-Warren L, Wang Y, Varaljay VA, Bailey MT, Goodman SD, Besner GE. An enhanced Lactobacillus reuteri biofilm formulation that increases protection against experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2018 Sep 1; 315: G408-G419.

                


                  Liu Y, Nelson T, Chakroff J, Cromeens B, Johnson J, Lannutti J, Besner GE. Comparison of polyglycolic acid, polycaprolactone, and collagen as scaffolds for the production of tissue engineered intestine. J Biomed Mater Res B Appl Biomater. 2018 Sep 30;  

                


                  McCulloh CJ, Olson JK, Wang Y, Zhou Y, Tengberg NH, Deshpande S, Besner GE. Treatment of experimental necrotizing enterocolitis with stem cell-derived exosomes. J Pediatr Surg. 2018 Jun; 53: 1215-1220.

                


                  Liu Y, Cromeens BP, Wang Y, Fisher K, Johnson J, Chakroff J, Besner GE. Comparison of Different In Vivo Incubation Sites to Produce Tissue-Engineered Small Intestine. Tissue Eng Part A. 2018 Mar 1;  

                


                  Cromeens BP, Wang Y, Liu Y, Johnson J, Besner GE. Critical intestinal cells originate from the host in enteroid-derived tissue-engineered intestine. J Surg Res. 2018 Mar; 223: 155-164.

                


                  Drucker NA, McCulloh CJ, Li B, Pierro A, Besner GE, Markel TA. Stem cell therapy in necrotizing enterocolitis: Current state and future directions. Semin Pediatr Surg. 2018 Feb; 27: 57-64.

                


                  Nordin AB, Sales SP, Besner GE, Levitt MA, Wood RJ, Kenney BD. Effective methods to decrease surgical site infections in pediatric gastrointestinal surgery. J Pediatr Surg. 2017 Oct 10;  

                


                  Olson JK, Deming LA, King DR, Rager TM, Gartner S, Huibregtse N, Moss RL, Besner GE. Single visit surgery for pediatric ambulatory surgical procedures: a satisfaction and cost analysis. J Pediatr Surg. 2017 Oct 10;  

                


                  Aldrink JH, Gonzalez DO, Sales SP, Deans KJ, Besner GE, Hewitt GD. Using quality improvement methodology to improve ovarian salvage for benign ovarian masses. J Pediatr Surg. 2017 Oct 10;  

                


                  Shen S, Wang H, Xue Y, Yuan L, Zhou X, Zhao Z, Dong E, Liu B, Liu W, Cromeens B, Adler B, Besner G, Xu RX. Freeform fabrication of tissue-simulating phantom for potential use of surgical planning in conjoined twins separation surgery. Sci Rep. 2017 Sep 8; 7: 11048.

                


                  Zhou Y, Wang Y, Olson J, Yang J, Besner GE. Heparin-binding EGF-like growth factor promotes neuronal nitric oxide synthase expression and protects the enteric nervous system after necrotizing enterocolitis. Pediatr Res. 2017 Sep; 82: 490-500.

                


                  Cromeens BP, Ray WC, Hoehne B, Abayneh F, Adler B, Besner GE. Facilitating surgeon understanding of complex anatomy using a three-dimensional printed model. J Surg Res. 2017 Aug; 216: 18-25.

                


                  McCulloh CJ, Olson JK, Wang Y, Vu J, Gartner S, Besner GE. Evaluating the efficacy of different types of stem cells in preserving gut barrier function in necrotizing enterocolitis. J Surg Res. 2017 Jun 15; 214: 278-285.

                


                  McCulloh CJ, Olson JK, Zhou Y, Wang Y, Besner GE. Stem cells and necrotizing enterocolitis: A direct comparison of the efficacy of multiple types of stem cells. J Pediatr Surg. 2017 Jun; 52: 999-1005.

                


                  Cromeens BP, Lisciandro RE, Brilli RJ, Askegard-Giesmann JR, Kenney BD, Besner GE. Identifying Adverse Events in Pediatric Surgery: Comparing Morbidity and Mortality Conference with the NSQIP-Pediatric System. J Am Coll Surg. 2017 May; 224: 945-953.

View More Publications

Research

Lab(s)

Center for Perinatal Research

Dr. Gail Besner’s primary research began in 1990 with the identification of the growth factor “heparin-binding EGF-like growth factor” (HB-EGF). The long range goal of this research is determine whether or not HB-EGF could be used in therapies to protect and treat intestinal damage in high-risk neonates. Her studies have shown that HB-EGF’s anti-inflammatory effects and chemical properties play a vital role in the regenerating of intestinal cells after they have been damaged. Lab research has shown that HB-EGF can protect the intestine from damage caused by hemorrhagic shock, blood supply restriction and necrotizing enterocolitis. Clinical studies are on the horizon to further test HB-EGF as a treatment option. Publications

                  Ettinger NA, Hill VL, Russ CM, Rakoczy KJ, Fallat ME, Wright TN, Choong K, Agus MSD, Hsu B, SECTION ON CRITICAL CARE, COMMITTEE ON HOSPITAL CARE, SECTION ON SURGERY., Mack E, Day S, Lowrie L, Siegel L, Srinivasan V, Gadepalli S, Hirshberg EL, Kissoon N, October T, Tamburro RF, Rotta A, Tellez S, Rauch DA, Ernst K, Vinocur C, Lam VT, Romito B, Hanson N, Gigli KH, Mauro M, Leonard MS, Alexander SN, Davidoff A, Besner GE, Browne M, Downard CD, Gow KW, Islam S, Saunders Walsh D, Williams RF, Thorne V. Guidance for Structuring a Pediatric Intermediate Care Unit. Pediatrics. 2022 May 1; 149: 

                


                  Dunn M, Savoie K, Erdem G, Dykes MW, Buckingham D, Spencer S, Besner G, Kenney B. Quality improvement methodology can reduce hospitalisation for abscess management. Emerg Med J. 2022 Jan 11;  

                


                  Ragan MV, Wala SJ, Goodman SD, Bailey MT, Besner GE. Next-Generation Probiotic Therapy to Protect the Intestines From Injury. Front Cell Infect Microbiol. 2022; 12: 863949.

                


                  Galley JD, Mar P, Wang Y, Han R, Rajab A, Besner GE. Urine-derived extracellular vesicle miRNAs as possible biomarkers for and mediators of necrotizing enterocolitis: A proof of concept study. J Pediatr Surg. 2021 Nov; 56: 1966-1975.

                


                  Blakely ML, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK, Besner GE, Das A, Ohls RK, Truog WE, Nelin LD, Poindexter BB, Pedroza C, Walsh MC, Stoll BJ, Geller R, Kennedy KA, Dimmitt RA, Carlo WA, Cotten CM, Laptook AR, Van Meurs KP, Calkins KL, Sokol GM, Sanchez PJ, Wyckoff MH, Patel RM, Frantz ID 3rd, Shankaran S, D'Angio CT, Yoder BA, Bell EF, Watterberg KL, Martin CA, Harmon CM, Rice H, Kurkchubasche AG, Sylvester K, Dunn JCY, Markel TA, Diesen DL, Bhatia AM, Flake A, Chwals WJ, Brown R, Bass KD, St Peter SD, Shanti CM, Pegoli W Jr, Skarda D, Shilyansky J, Lemon DG, Mosquera RA, Peralta-Carcelen M, Goldstein RF, Vohr BR, Purdy IB, Hines AC, Maitre NL, Heyne RJ, DeMauro SB, McGowan EC, Yolton K, Kilbride HW, Natarajan G, Yost K, Winter S, Colaizy TT, Laughon MM, Lakshminrusimha S, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network.. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial. Ann Surg. 2021 Oct 1; 274: e370-e380.

                


                  Shelby RD, Mar P, Janzow GE, Mashburn-Warren L, Tengberg N, Navarro JB, Allen JM, Wickham J, Wang Y, Bailey MT, Goodman SD, Besner GE. Antibacterial and anti-inflammatory effects of Lactobacillus reuteri in its biofilm state contribute to its beneficial effects in a rat model of experimental necrotizing enterocolitis. J Pediatr Surg. 2021 Sep 20;  

                


                  Brigstock NM, Besner GE. Development of an academic RVU (aRVU) system to promote pediatric surgical academic productivity. J Pediatr Surg. 2021 Sep 20;  

                


                  Wang Y, Jaggers RM, Mar P, Galley JD, Shaffer T, Rajab A, Deshpande S, Mashburn-Warren L, Buzzo JR, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in its biofilm state promotes neurodevelopment after experimental necrotizing enterocolitis in rats. Brain Behav Immun Health. 2021 Jul; 14: 

                


                  Al-Hadidi A, Navarro J, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in Its Biofilm State Improves Protection from Experimental Necrotizing Enterocolitis. Nutrients. 2021 Mar 12; 13: 

                


                  Lawrence AE, Huntington JT, Savoie K, Dykes M, Aldrink JH, Richards H, Besner GE, Kenney B, Fisher J, Minneci PC, Michalsky MP. Improving care through standardized treatment of spontaneous pneumothorax. J Pediatr Surg. 2021 Jan; 56: 55-60.

                


                  Nitkin CR, Rajasingh J, Pisano C, Besner GE, Thébaud B, Sampath V. Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Pediatr Res. 2020 Jan; 87: 265-276.

                


                  Pisano C, Galley J, Elbahrawy M, Wang Y, Farrell A, Brigstock D, Besner GE. Human Breast Milk-Derived Extracellular Vesicles in the Protection Against Experimental Necrotizing Enterocolitis. J Pediatr Surg. 2020 Jan; 55: 54-58.

                


                  Savoie KB, Shelby RD, Dykes MW, Diefenbach KA, Besner GE, Kenney BD. Volume of Irrigation Does Not Affect Rate of Abscess in Perforated Appendicitis. J Laparoendosc Adv Surg Tech A. 2019 Oct; 29: 1232-1238.

                


                  Shelby RD, Tengberg N, Conces M, Olson JK, Navarro JB, Bailey MT, Goodman SD, Besner GE. Development of a Standardized Scoring System to Assess a Murine Model of Clostridium difficile Colitis. J Invest Surg. 2019 Mar 20;  1-9.

                


                  Shelby RD, Cromeens B, Rager TM, Besner GE. Influence of Growth Factors on the Development of Necrotizing Enterocolitis. Clin Perinatol. 2019 Mar; 46: 51-64.

                


                  Perrone EE, Olson J, Golden JM, Besner GE, Gayer CP, Islam S, Gollin G. Closing gastroschisis: The good, the bad, and the not-so ugly. J Pediatr Surg. 2019 Jan; 54: 60-64.

                


                  Nordin AB, Diefenbach K, Sales SP, Christensen J, Besner GE, Kenney BD. Gangrenous appendicitis: No longer complicated. J Pediatr Surg. 2018 Nov 6;  

                


                  Liu Y, Wang Y, Chakroff J, Johnson J, Farrell A, Besner GE. Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors. Tissue Eng Part A. 2018 Oct 4;  

                


                  Pisano C, Besner GE. Potential role of stem cells in disease prevention based on a murine model of experimental necrotizing enterocolitis. J Pediatr Surg. 2018 Sep 5;  

                


                  Olson JK, Navarro JB, Allen JM, McCulloh CJ, Mashburn-Warren L, Wang Y, Varaljay VA, Bailey MT, Goodman SD, Besner GE. An enhanced Lactobacillus reuteri biofilm formulation that increases protection against experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2018 Sep 1; 315: G408-G419.

                


                  Liu Y, Nelson T, Chakroff J, Cromeens B, Johnson J, Lannutti J, Besner GE. Comparison of polyglycolic acid, polycaprolactone, and collagen as scaffolds for the production of tissue engineered intestine. J Biomed Mater Res B Appl Biomater. 2018 Sep 30;  

                


                  McCulloh CJ, Olson JK, Wang Y, Zhou Y, Tengberg NH, Deshpande S, Besner GE. Treatment of experimental necrotizing enterocolitis with stem cell-derived exosomes. J Pediatr Surg. 2018 Jun; 53: 1215-1220.

                


                  Liu Y, Cromeens BP, Wang Y, Fisher K, Johnson J, Chakroff J, Besner GE. Comparison of Different In Vivo Incubation Sites to Produce Tissue-Engineered Small Intestine. Tissue Eng Part A. 2018 Mar 1;  

                


                  Cromeens BP, Wang Y, Liu Y, Johnson J, Besner GE. Critical intestinal cells originate from the host in enteroid-derived tissue-engineered intestine. J Surg Res. 2018 Mar; 223: 155-164.

                


                  Drucker NA, McCulloh CJ, Li B, Pierro A, Besner GE, Markel TA. Stem cell therapy in necrotizing enterocolitis: Current state and future directions. Semin Pediatr Surg. 2018 Feb; 27: 57-64.

                


                  Nordin AB, Sales SP, Besner GE, Levitt MA, Wood RJ, Kenney BD. Effective methods to decrease surgical site infections in pediatric gastrointestinal surgery. J Pediatr Surg. 2017 Oct 10;  

                


                  Olson JK, Deming LA, King DR, Rager TM, Gartner S, Huibregtse N, Moss RL, Besner GE. Single visit surgery for pediatric ambulatory surgical procedures: a satisfaction and cost analysis. J Pediatr Surg. 2017 Oct 10;  

                


                  Aldrink JH, Gonzalez DO, Sales SP, Deans KJ, Besner GE, Hewitt GD. Using quality improvement methodology to improve ovarian salvage for benign ovarian masses. J Pediatr Surg. 2017 Oct 10;  

                


                  Shen S, Wang H, Xue Y, Yuan L, Zhou X, Zhao Z, Dong E, Liu B, Liu W, Cromeens B, Adler B, Besner G, Xu RX. Freeform fabrication of tissue-simulating phantom for potential use of surgical planning in conjoined twins separation surgery. Sci Rep. 2017 Sep 8; 7: 11048.

                


                  Zhou Y, Wang Y, Olson J, Yang J, Besner GE. Heparin-binding EGF-like growth factor promotes neuronal nitric oxide synthase expression and protects the enteric nervous system after necrotizing enterocolitis. Pediatr Res. 2017 Sep; 82: 490-500.

                


                  Cromeens BP, Ray WC, Hoehne B, Abayneh F, Adler B, Besner GE. Facilitating surgeon understanding of complex anatomy using a three-dimensional printed model. J Surg Res. 2017 Aug; 216: 18-25.

                


                  McCulloh CJ, Olson JK, Wang Y, Vu J, Gartner S, Besner GE. Evaluating the efficacy of different types of stem cells in preserving gut barrier function in necrotizing enterocolitis. J Surg Res. 2017 Jun 15; 214: 278-285.

                


                  McCulloh CJ, Olson JK, Zhou Y, Wang Y, Besner GE. Stem cells and necrotizing enterocolitis: A direct comparison of the efficacy of multiple types of stem cells. J Pediatr Surg. 2017 Jun; 52: 999-1005.

                


                  Cromeens BP, Lisciandro RE, Brilli RJ, Askegard-Giesmann JR, Kenney BD, Besner GE. Identifying Adverse Events in Pediatric Surgery: Comparing Morbidity and Mortality Conference with the NSQIP-Pediatric System. J Am Coll Surg. 2017 May; 224: 945-953.

View More Publications

Lab(s)

Center for Perinatal Research

Dr. Gail Besner’s primary research began in 1990 with the identification of the growth factor “heparin-binding EGF-like growth factor” (HB-EGF). The long range goal of this research is determine whether or not HB-EGF could be used in therapies to protect and treat intestinal damage in high-risk neonates. Her studies have shown that HB-EGF’s anti-inflammatory effects and chemical properties play a vital role in the regenerating of intestinal cells after they have been damaged. Lab research has shown that HB-EGF can protect the intestine from damage caused by hemorrhagic shock, blood supply restriction and necrotizing enterocolitis. Clinical studies are on the horizon to further test HB-EGF as a treatment option. Publications

                  Ettinger NA, Hill VL, Russ CM, Rakoczy KJ, Fallat ME, Wright TN, Choong K, Agus MSD, Hsu B, SECTION ON CRITICAL CARE, COMMITTEE ON HOSPITAL CARE, SECTION ON SURGERY., Mack E, Day S, Lowrie L, Siegel L, Srinivasan V, Gadepalli S, Hirshberg EL, Kissoon N, October T, Tamburro RF, Rotta A, Tellez S, Rauch DA, Ernst K, Vinocur C, Lam VT, Romito B, Hanson N, Gigli KH, Mauro M, Leonard MS, Alexander SN, Davidoff A, Besner GE, Browne M, Downard CD, Gow KW, Islam S, Saunders Walsh D, Williams RF, Thorne V. Guidance for Structuring a Pediatric Intermediate Care Unit. Pediatrics. 2022 May 1; 149: 

                


                  Dunn M, Savoie K, Erdem G, Dykes MW, Buckingham D, Spencer S, Besner G, Kenney B. Quality improvement methodology can reduce hospitalisation for abscess management. Emerg Med J. 2022 Jan 11;  

                


                  Ragan MV, Wala SJ, Goodman SD, Bailey MT, Besner GE. Next-Generation Probiotic Therapy to Protect the Intestines From Injury. Front Cell Infect Microbiol. 2022; 12: 863949.

                


                  Galley JD, Mar P, Wang Y, Han R, Rajab A, Besner GE. Urine-derived extracellular vesicle miRNAs as possible biomarkers for and mediators of necrotizing enterocolitis: A proof of concept study. J Pediatr Surg. 2021 Nov; 56: 1966-1975.

                


                  Blakely ML, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK, Besner GE, Das A, Ohls RK, Truog WE, Nelin LD, Poindexter BB, Pedroza C, Walsh MC, Stoll BJ, Geller R, Kennedy KA, Dimmitt RA, Carlo WA, Cotten CM, Laptook AR, Van Meurs KP, Calkins KL, Sokol GM, Sanchez PJ, Wyckoff MH, Patel RM, Frantz ID 3rd, Shankaran S, D'Angio CT, Yoder BA, Bell EF, Watterberg KL, Martin CA, Harmon CM, Rice H, Kurkchubasche AG, Sylvester K, Dunn JCY, Markel TA, Diesen DL, Bhatia AM, Flake A, Chwals WJ, Brown R, Bass KD, St Peter SD, Shanti CM, Pegoli W Jr, Skarda D, Shilyansky J, Lemon DG, Mosquera RA, Peralta-Carcelen M, Goldstein RF, Vohr BR, Purdy IB, Hines AC, Maitre NL, Heyne RJ, DeMauro SB, McGowan EC, Yolton K, Kilbride HW, Natarajan G, Yost K, Winter S, Colaizy TT, Laughon MM, Lakshminrusimha S, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network.. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial. Ann Surg. 2021 Oct 1; 274: e370-e380.

                


                  Shelby RD, Mar P, Janzow GE, Mashburn-Warren L, Tengberg N, Navarro JB, Allen JM, Wickham J, Wang Y, Bailey MT, Goodman SD, Besner GE. Antibacterial and anti-inflammatory effects of Lactobacillus reuteri in its biofilm state contribute to its beneficial effects in a rat model of experimental necrotizing enterocolitis. J Pediatr Surg. 2021 Sep 20;  

                


                  Brigstock NM, Besner GE. Development of an academic RVU (aRVU) system to promote pediatric surgical academic productivity. J Pediatr Surg. 2021 Sep 20;  

                


                  Wang Y, Jaggers RM, Mar P, Galley JD, Shaffer T, Rajab A, Deshpande S, Mashburn-Warren L, Buzzo JR, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in its biofilm state promotes neurodevelopment after experimental necrotizing enterocolitis in rats. Brain Behav Immun Health. 2021 Jul; 14: 

                


                  Al-Hadidi A, Navarro J, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in Its Biofilm State Improves Protection from Experimental Necrotizing Enterocolitis. Nutrients. 2021 Mar 12; 13: 

                


                  Lawrence AE, Huntington JT, Savoie K, Dykes M, Aldrink JH, Richards H, Besner GE, Kenney B, Fisher J, Minneci PC, Michalsky MP. Improving care through standardized treatment of spontaneous pneumothorax. J Pediatr Surg. 2021 Jan; 56: 55-60.

                


                  Nitkin CR, Rajasingh J, Pisano C, Besner GE, Thébaud B, Sampath V. Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Pediatr Res. 2020 Jan; 87: 265-276.

                


                  Pisano C, Galley J, Elbahrawy M, Wang Y, Farrell A, Brigstock D, Besner GE. Human Breast Milk-Derived Extracellular Vesicles in the Protection Against Experimental Necrotizing Enterocolitis. J Pediatr Surg. 2020 Jan; 55: 54-58.

                


                  Savoie KB, Shelby RD, Dykes MW, Diefenbach KA, Besner GE, Kenney BD. Volume of Irrigation Does Not Affect Rate of Abscess in Perforated Appendicitis. J Laparoendosc Adv Surg Tech A. 2019 Oct; 29: 1232-1238.

                


                  Shelby RD, Tengberg N, Conces M, Olson JK, Navarro JB, Bailey MT, Goodman SD, Besner GE. Development of a Standardized Scoring System to Assess a Murine Model of Clostridium difficile Colitis. J Invest Surg. 2019 Mar 20;  1-9.

                


                  Shelby RD, Cromeens B, Rager TM, Besner GE. Influence of Growth Factors on the Development of Necrotizing Enterocolitis. Clin Perinatol. 2019 Mar; 46: 51-64.

                


                  Perrone EE, Olson J, Golden JM, Besner GE, Gayer CP, Islam S, Gollin G. Closing gastroschisis: The good, the bad, and the not-so ugly. J Pediatr Surg. 2019 Jan; 54: 60-64.

                


                  Nordin AB, Diefenbach K, Sales SP, Christensen J, Besner GE, Kenney BD. Gangrenous appendicitis: No longer complicated. J Pediatr Surg. 2018 Nov 6;  

                


                  Liu Y, Wang Y, Chakroff J, Johnson J, Farrell A, Besner GE. Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors. Tissue Eng Part A. 2018 Oct 4;  

                


                  Pisano C, Besner GE. Potential role of stem cells in disease prevention based on a murine model of experimental necrotizing enterocolitis. J Pediatr Surg. 2018 Sep 5;  

                


                  Olson JK, Navarro JB, Allen JM, McCulloh CJ, Mashburn-Warren L, Wang Y, Varaljay VA, Bailey MT, Goodman SD, Besner GE. An enhanced Lactobacillus reuteri biofilm formulation that increases protection against experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2018 Sep 1; 315: G408-G419.

                


                  Liu Y, Nelson T, Chakroff J, Cromeens B, Johnson J, Lannutti J, Besner GE. Comparison of polyglycolic acid, polycaprolactone, and collagen as scaffolds for the production of tissue engineered intestine. J Biomed Mater Res B Appl Biomater. 2018 Sep 30;  

                


                  McCulloh CJ, Olson JK, Wang Y, Zhou Y, Tengberg NH, Deshpande S, Besner GE. Treatment of experimental necrotizing enterocolitis with stem cell-derived exosomes. J Pediatr Surg. 2018 Jun; 53: 1215-1220.

                


                  Liu Y, Cromeens BP, Wang Y, Fisher K, Johnson J, Chakroff J, Besner GE. Comparison of Different In Vivo Incubation Sites to Produce Tissue-Engineered Small Intestine. Tissue Eng Part A. 2018 Mar 1;  

                


                  Cromeens BP, Wang Y, Liu Y, Johnson J, Besner GE. Critical intestinal cells originate from the host in enteroid-derived tissue-engineered intestine. J Surg Res. 2018 Mar; 223: 155-164.

                


                  Drucker NA, McCulloh CJ, Li B, Pierro A, Besner GE, Markel TA. Stem cell therapy in necrotizing enterocolitis: Current state and future directions. Semin Pediatr Surg. 2018 Feb; 27: 57-64.

                


                  Nordin AB, Sales SP, Besner GE, Levitt MA, Wood RJ, Kenney BD. Effective methods to decrease surgical site infections in pediatric gastrointestinal surgery. J Pediatr Surg. 2017 Oct 10;  

                


                  Olson JK, Deming LA, King DR, Rager TM, Gartner S, Huibregtse N, Moss RL, Besner GE. Single visit surgery for pediatric ambulatory surgical procedures: a satisfaction and cost analysis. J Pediatr Surg. 2017 Oct 10;  

                


                  Aldrink JH, Gonzalez DO, Sales SP, Deans KJ, Besner GE, Hewitt GD. Using quality improvement methodology to improve ovarian salvage for benign ovarian masses. J Pediatr Surg. 2017 Oct 10;  

                


                  Shen S, Wang H, Xue Y, Yuan L, Zhou X, Zhao Z, Dong E, Liu B, Liu W, Cromeens B, Adler B, Besner G, Xu RX. Freeform fabrication of tissue-simulating phantom for potential use of surgical planning in conjoined twins separation surgery. Sci Rep. 2017 Sep 8; 7: 11048.

                


                  Zhou Y, Wang Y, Olson J, Yang J, Besner GE. Heparin-binding EGF-like growth factor promotes neuronal nitric oxide synthase expression and protects the enteric nervous system after necrotizing enterocolitis. Pediatr Res. 2017 Sep; 82: 490-500.

                


                  Cromeens BP, Ray WC, Hoehne B, Abayneh F, Adler B, Besner GE. Facilitating surgeon understanding of complex anatomy using a three-dimensional printed model. J Surg Res. 2017 Aug; 216: 18-25.

                


                  McCulloh CJ, Olson JK, Wang Y, Vu J, Gartner S, Besner GE. Evaluating the efficacy of different types of stem cells in preserving gut barrier function in necrotizing enterocolitis. J Surg Res. 2017 Jun 15; 214: 278-285.

                


                  McCulloh CJ, Olson JK, Zhou Y, Wang Y, Besner GE. Stem cells and necrotizing enterocolitis: A direct comparison of the efficacy of multiple types of stem cells. J Pediatr Surg. 2017 Jun; 52: 999-1005.

                


                  Cromeens BP, Lisciandro RE, Brilli RJ, Askegard-Giesmann JR, Kenney BD, Besner GE. Identifying Adverse Events in Pediatric Surgery: Comparing Morbidity and Mortality Conference with the NSQIP-Pediatric System. J Am Coll Surg. 2017 May; 224: 945-953.

View More Publications

Lab(s)

Center for Perinatal Research

Dr. Gail Besner’s primary research began in 1990 with the identification of the growth factor “heparin-binding EGF-like growth factor” (HB-EGF). The long range goal of this research is determine whether or not HB-EGF could be used in therapies to protect and treat intestinal damage in high-risk neonates.

Lab(s)

Center for Perinatal Research

  • Center for Perinatal Research

Her studies have shown that HB-EGF’s anti-inflammatory effects and chemical properties play a vital role in the regenerating of intestinal cells after they have been damaged. Lab research has shown that HB-EGF can protect the intestine from damage caused by hemorrhagic shock, blood supply restriction and necrotizing enterocolitis. Clinical studies are on the horizon to further test HB-EGF as a treatment option.

                  Ettinger NA, Hill VL, Russ CM, Rakoczy KJ, Fallat ME, Wright TN, Choong K, Agus MSD, Hsu B, SECTION ON CRITICAL CARE, COMMITTEE ON HOSPITAL CARE, SECTION ON SURGERY., Mack E, Day S, Lowrie L, Siegel L, Srinivasan V, Gadepalli S, Hirshberg EL, Kissoon N, October T, Tamburro RF, Rotta A, Tellez S, Rauch DA, Ernst K, Vinocur C, Lam VT, Romito B, Hanson N, Gigli KH, Mauro M, Leonard MS, Alexander SN, Davidoff A, Besner GE, Browne M, Downard CD, Gow KW, Islam S, Saunders Walsh D, Williams RF, Thorne V. Guidance for Structuring a Pediatric Intermediate Care Unit. Pediatrics. 2022 May 1; 149: 

                


                  Dunn M, Savoie K, Erdem G, Dykes MW, Buckingham D, Spencer S, Besner G, Kenney B. Quality improvement methodology can reduce hospitalisation for abscess management. Emerg Med J. 2022 Jan 11;  

                


                  Ragan MV, Wala SJ, Goodman SD, Bailey MT, Besner GE. Next-Generation Probiotic Therapy to Protect the Intestines From Injury. Front Cell Infect Microbiol. 2022; 12: 863949.

                


                  Galley JD, Mar P, Wang Y, Han R, Rajab A, Besner GE. Urine-derived extracellular vesicle miRNAs as possible biomarkers for and mediators of necrotizing enterocolitis: A proof of concept study. J Pediatr Surg. 2021 Nov; 56: 1966-1975.

                


                  Blakely ML, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK, Besner GE, Das A, Ohls RK, Truog WE, Nelin LD, Poindexter BB, Pedroza C, Walsh MC, Stoll BJ, Geller R, Kennedy KA, Dimmitt RA, Carlo WA, Cotten CM, Laptook AR, Van Meurs KP, Calkins KL, Sokol GM, Sanchez PJ, Wyckoff MH, Patel RM, Frantz ID 3rd, Shankaran S, D'Angio CT, Yoder BA, Bell EF, Watterberg KL, Martin CA, Harmon CM, Rice H, Kurkchubasche AG, Sylvester K, Dunn JCY, Markel TA, Diesen DL, Bhatia AM, Flake A, Chwals WJ, Brown R, Bass KD, St Peter SD, Shanti CM, Pegoli W Jr, Skarda D, Shilyansky J, Lemon DG, Mosquera RA, Peralta-Carcelen M, Goldstein RF, Vohr BR, Purdy IB, Hines AC, Maitre NL, Heyne RJ, DeMauro SB, McGowan EC, Yolton K, Kilbride HW, Natarajan G, Yost K, Winter S, Colaizy TT, Laughon MM, Lakshminrusimha S, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network.. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial. Ann Surg. 2021 Oct 1; 274: e370-e380.

                


                  Shelby RD, Mar P, Janzow GE, Mashburn-Warren L, Tengberg N, Navarro JB, Allen JM, Wickham J, Wang Y, Bailey MT, Goodman SD, Besner GE. Antibacterial and anti-inflammatory effects of Lactobacillus reuteri in its biofilm state contribute to its beneficial effects in a rat model of experimental necrotizing enterocolitis. J Pediatr Surg. 2021 Sep 20;  

                


                  Brigstock NM, Besner GE. Development of an academic RVU (aRVU) system to promote pediatric surgical academic productivity. J Pediatr Surg. 2021 Sep 20;  

                


                  Wang Y, Jaggers RM, Mar P, Galley JD, Shaffer T, Rajab A, Deshpande S, Mashburn-Warren L, Buzzo JR, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in its biofilm state promotes neurodevelopment after experimental necrotizing enterocolitis in rats. Brain Behav Immun Health. 2021 Jul; 14: 

                


                  Al-Hadidi A, Navarro J, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in Its Biofilm State Improves Protection from Experimental Necrotizing Enterocolitis. Nutrients. 2021 Mar 12; 13: 

                


                  Lawrence AE, Huntington JT, Savoie K, Dykes M, Aldrink JH, Richards H, Besner GE, Kenney B, Fisher J, Minneci PC, Michalsky MP. Improving care through standardized treatment of spontaneous pneumothorax. J Pediatr Surg. 2021 Jan; 56: 55-60.

                


                  Nitkin CR, Rajasingh J, Pisano C, Besner GE, Thébaud B, Sampath V. Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Pediatr Res. 2020 Jan; 87: 265-276.

                


                  Pisano C, Galley J, Elbahrawy M, Wang Y, Farrell A, Brigstock D, Besner GE. Human Breast Milk-Derived Extracellular Vesicles in the Protection Against Experimental Necrotizing Enterocolitis. J Pediatr Surg. 2020 Jan; 55: 54-58.

                


                  Savoie KB, Shelby RD, Dykes MW, Diefenbach KA, Besner GE, Kenney BD. Volume of Irrigation Does Not Affect Rate of Abscess in Perforated Appendicitis. J Laparoendosc Adv Surg Tech A. 2019 Oct; 29: 1232-1238.

                


                  Shelby RD, Tengberg N, Conces M, Olson JK, Navarro JB, Bailey MT, Goodman SD, Besner GE. Development of a Standardized Scoring System to Assess a Murine Model of Clostridium difficile Colitis. J Invest Surg. 2019 Mar 20;  1-9.

                


                  Shelby RD, Cromeens B, Rager TM, Besner GE. Influence of Growth Factors on the Development of Necrotizing Enterocolitis. Clin Perinatol. 2019 Mar; 46: 51-64.

                


                  Perrone EE, Olson J, Golden JM, Besner GE, Gayer CP, Islam S, Gollin G. Closing gastroschisis: The good, the bad, and the not-so ugly. J Pediatr Surg. 2019 Jan; 54: 60-64.

                


                  Nordin AB, Diefenbach K, Sales SP, Christensen J, Besner GE, Kenney BD. Gangrenous appendicitis: No longer complicated. J Pediatr Surg. 2018 Nov 6;  

                


                  Liu Y, Wang Y, Chakroff J, Johnson J, Farrell A, Besner GE. Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors. Tissue Eng Part A. 2018 Oct 4;  

                


                  Pisano C, Besner GE. Potential role of stem cells in disease prevention based on a murine model of experimental necrotizing enterocolitis. J Pediatr Surg. 2018 Sep 5;  

                


                  Olson JK, Navarro JB, Allen JM, McCulloh CJ, Mashburn-Warren L, Wang Y, Varaljay VA, Bailey MT, Goodman SD, Besner GE. An enhanced Lactobacillus reuteri biofilm formulation that increases protection against experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2018 Sep 1; 315: G408-G419.

                


                  Liu Y, Nelson T, Chakroff J, Cromeens B, Johnson J, Lannutti J, Besner GE. Comparison of polyglycolic acid, polycaprolactone, and collagen as scaffolds for the production of tissue engineered intestine. J Biomed Mater Res B Appl Biomater. 2018 Sep 30;  

                


                  McCulloh CJ, Olson JK, Wang Y, Zhou Y, Tengberg NH, Deshpande S, Besner GE. Treatment of experimental necrotizing enterocolitis with stem cell-derived exosomes. J Pediatr Surg. 2018 Jun; 53: 1215-1220.

                


                  Liu Y, Cromeens BP, Wang Y, Fisher K, Johnson J, Chakroff J, Besner GE. Comparison of Different In Vivo Incubation Sites to Produce Tissue-Engineered Small Intestine. Tissue Eng Part A. 2018 Mar 1;  

                


                  Cromeens BP, Wang Y, Liu Y, Johnson J, Besner GE. Critical intestinal cells originate from the host in enteroid-derived tissue-engineered intestine. J Surg Res. 2018 Mar; 223: 155-164.

                


                  Drucker NA, McCulloh CJ, Li B, Pierro A, Besner GE, Markel TA. Stem cell therapy in necrotizing enterocolitis: Current state and future directions. Semin Pediatr Surg. 2018 Feb; 27: 57-64.

                


                  Nordin AB, Sales SP, Besner GE, Levitt MA, Wood RJ, Kenney BD. Effective methods to decrease surgical site infections in pediatric gastrointestinal surgery. J Pediatr Surg. 2017 Oct 10;  

                


                  Olson JK, Deming LA, King DR, Rager TM, Gartner S, Huibregtse N, Moss RL, Besner GE. Single visit surgery for pediatric ambulatory surgical procedures: a satisfaction and cost analysis. J Pediatr Surg. 2017 Oct 10;  

                


                  Aldrink JH, Gonzalez DO, Sales SP, Deans KJ, Besner GE, Hewitt GD. Using quality improvement methodology to improve ovarian salvage for benign ovarian masses. J Pediatr Surg. 2017 Oct 10;  

                


                  Shen S, Wang H, Xue Y, Yuan L, Zhou X, Zhao Z, Dong E, Liu B, Liu W, Cromeens B, Adler B, Besner G, Xu RX. Freeform fabrication of tissue-simulating phantom for potential use of surgical planning in conjoined twins separation surgery. Sci Rep. 2017 Sep 8; 7: 11048.

                


                  Zhou Y, Wang Y, Olson J, Yang J, Besner GE. Heparin-binding EGF-like growth factor promotes neuronal nitric oxide synthase expression and protects the enteric nervous system after necrotizing enterocolitis. Pediatr Res. 2017 Sep; 82: 490-500.

                


                  Cromeens BP, Ray WC, Hoehne B, Abayneh F, Adler B, Besner GE. Facilitating surgeon understanding of complex anatomy using a three-dimensional printed model. J Surg Res. 2017 Aug; 216: 18-25.

                


                  McCulloh CJ, Olson JK, Wang Y, Vu J, Gartner S, Besner GE. Evaluating the efficacy of different types of stem cells in preserving gut barrier function in necrotizing enterocolitis. J Surg Res. 2017 Jun 15; 214: 278-285.

                


                  McCulloh CJ, Olson JK, Zhou Y, Wang Y, Besner GE. Stem cells and necrotizing enterocolitis: A direct comparison of the efficacy of multiple types of stem cells. J Pediatr Surg. 2017 Jun; 52: 999-1005.

                


                  Cromeens BP, Lisciandro RE, Brilli RJ, Askegard-Giesmann JR, Kenney BD, Besner GE. Identifying Adverse Events in Pediatric Surgery: Comparing Morbidity and Mortality Conference with the NSQIP-Pediatric System. J Am Coll Surg. 2017 May; 224: 945-953.

View More Publications

  • Ettinger NA, Hill VL, Russ CM, Rakoczy KJ, Fallat ME, Wright TN, Choong K, Agus MSD, Hsu B, SECTION ON CRITICAL CARE, COMMITTEE ON HOSPITAL CARE, SECTION ON SURGERY., Mack E, Day S, Lowrie L, Siegel L, Srinivasan V, Gadepalli S, Hirshberg EL, Kissoon N, October T, Tamburro RF, Rotta A, Tellez S, Rauch DA, Ernst K, Vinocur C, Lam VT, Romito B, Hanson N, Gigli KH, Mauro M, Leonard MS, Alexander SN, Davidoff A, Besner GE, Browne M, Downard CD, Gow KW, Islam S, Saunders Walsh D, Williams RF, Thorne V. Guidance for Structuring a Pediatric Intermediate Care Unit. Pediatrics. 2022 May 1; 149:
  • Dunn M, Savoie K, Erdem G, Dykes MW, Buckingham D, Spencer S, Besner G, Kenney B. Quality improvement methodology can reduce hospitalisation for abscess management. Emerg Med J. 2022 Jan 11;
  • Ragan MV, Wala SJ, Goodman SD, Bailey MT, Besner GE. Next-Generation Probiotic Therapy to Protect the Intestines From Injury. Front Cell Infect Microbiol. 2022; 12: 863949.
  • Galley JD, Mar P, Wang Y, Han R, Rajab A, Besner GE. Urine-derived extracellular vesicle miRNAs as possible biomarkers for and mediators of necrotizing enterocolitis: A proof of concept study. J Pediatr Surg. 2021 Nov; 56: 1966-1975.
  • Blakely ML, Tyson JE, Lally KP, Hintz SR, Eggleston B, Stevenson DK, Besner GE, Das A, Ohls RK, Truog WE, Nelin LD, Poindexter BB, Pedroza C, Walsh MC, Stoll BJ, Geller R, Kennedy KA, Dimmitt RA, Carlo WA, Cotten CM, Laptook AR, Van Meurs KP, Calkins KL, Sokol GM, Sanchez PJ, Wyckoff MH, Patel RM, Frantz ID 3rd, Shankaran S, D’Angio CT, Yoder BA, Bell EF, Watterberg KL, Martin CA, Harmon CM, Rice H, Kurkchubasche AG, Sylvester K, Dunn JCY, Markel TA, Diesen DL, Bhatia AM, Flake A, Chwals WJ, Brown R, Bass KD, St Peter SD, Shanti CM, Pegoli W Jr, Skarda D, Shilyansky J, Lemon DG, Mosquera RA, Peralta-Carcelen M, Goldstein RF, Vohr BR, Purdy IB, Hines AC, Maitre NL, Heyne RJ, DeMauro SB, McGowan EC, Yolton K, Kilbride HW, Natarajan G, Yost K, Winter S, Colaizy TT, Laughon MM, Lakshminrusimha S, Higgins RD, Eunice Kennedy Shriver National Institute of Child Health, Human Development Neonatal Research Network.. Initial Laparotomy Versus Peritoneal Drainage in Extremely Low Birthweight Infants With Surgical Necrotizing Enterocolitis or Isolated Intestinal Perforation: A Multicenter Randomized Clinical Trial. Ann Surg. 2021 Oct 1; 274: e370-e380.
  • Shelby RD, Mar P, Janzow GE, Mashburn-Warren L, Tengberg N, Navarro JB, Allen JM, Wickham J, Wang Y, Bailey MT, Goodman SD, Besner GE. Antibacterial and anti-inflammatory effects of Lactobacillus reuteri in its biofilm state contribute to its beneficial effects in a rat model of experimental necrotizing enterocolitis. J Pediatr Surg. 2021 Sep 20;
  • Brigstock NM, Besner GE. Development of an academic RVU (aRVU) system to promote pediatric surgical academic productivity. J Pediatr Surg. 2021 Sep 20;
  • Wang Y, Jaggers RM, Mar P, Galley JD, Shaffer T, Rajab A, Deshpande S, Mashburn-Warren L, Buzzo JR, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in its biofilm state promotes neurodevelopment after experimental necrotizing enterocolitis in rats. Brain Behav Immun Health. 2021 Jul; 14:
  • Al-Hadidi A, Navarro J, Goodman SD, Bailey MT, Besner GE. Lactobacillus reuteri in Its Biofilm State Improves Protection from Experimental Necrotizing Enterocolitis. Nutrients. 2021 Mar 12; 13:
  • Lawrence AE, Huntington JT, Savoie K, Dykes M, Aldrink JH, Richards H, Besner GE, Kenney B, Fisher J, Minneci PC, Michalsky MP. Improving care through standardized treatment of spontaneous pneumothorax. J Pediatr Surg. 2021 Jan; 56: 55-60.
  • Nitkin CR, Rajasingh J, Pisano C, Besner GE, Thébaud B, Sampath V. Stem cell therapy for preventing neonatal diseases in the 21st century: Current understanding and challenges. Pediatr Res. 2020 Jan; 87: 265-276.
  • Pisano C, Galley J, Elbahrawy M, Wang Y, Farrell A, Brigstock D, Besner GE. Human Breast Milk-Derived Extracellular Vesicles in the Protection Against Experimental Necrotizing Enterocolitis. J Pediatr Surg. 2020 Jan; 55: 54-58.
  • Savoie KB, Shelby RD, Dykes MW, Diefenbach KA, Besner GE, Kenney BD. Volume of Irrigation Does Not Affect Rate of Abscess in Perforated Appendicitis. J Laparoendosc Adv Surg Tech A. 2019 Oct; 29: 1232-1238.
  • Shelby RD, Tengberg N, Conces M, Olson JK, Navarro JB, Bailey MT, Goodman SD, Besner GE. Development of a Standardized Scoring System to Assess a Murine Model of Clostridium difficile Colitis. J Invest Surg. 2019 Mar 20; 1-9.
  • Shelby RD, Cromeens B, Rager TM, Besner GE. Influence of Growth Factors on the Development of Necrotizing Enterocolitis. Clin Perinatol. 2019 Mar; 46: 51-64.
  • Perrone EE, Olson J, Golden JM, Besner GE, Gayer CP, Islam S, Gollin G. Closing gastroschisis: The good, the bad, and the not-so ugly. J Pediatr Surg. 2019 Jan; 54: 60-64.
  • Nordin AB, Diefenbach K, Sales SP, Christensen J, Besner GE, Kenney BD. Gangrenous appendicitis: No longer complicated. J Pediatr Surg. 2018 Nov 6;
  • Liu Y, Wang Y, Chakroff J, Johnson J, Farrell A, Besner GE. Production of Tissue-Engineered Small Intestine in Rats with Different Ages of Cell Donors. Tissue Eng Part A. 2018 Oct 4;
  • Pisano C, Besner GE. Potential role of stem cells in disease prevention based on a murine model of experimental necrotizing enterocolitis. J Pediatr Surg. 2018 Sep 5;
  • Olson JK, Navarro JB, Allen JM, McCulloh CJ, Mashburn-Warren L, Wang Y, Varaljay VA, Bailey MT, Goodman SD, Besner GE. An enhanced Lactobacillus reuteri biofilm formulation that increases protection against experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2018 Sep 1; 315: G408-G419.
  • Liu Y, Nelson T, Chakroff J, Cromeens B, Johnson J, Lannutti J, Besner GE. Comparison of polyglycolic acid, polycaprolactone, and collagen as scaffolds for the production of tissue engineered intestine. J Biomed Mater Res B Appl Biomater. 2018 Sep 30;
  • McCulloh CJ, Olson JK, Wang Y, Zhou Y, Tengberg NH, Deshpande S, Besner GE. Treatment of experimental necrotizing enterocolitis with stem cell-derived exosomes. J Pediatr Surg. 2018 Jun; 53: 1215-1220.
  • Liu Y, Cromeens BP, Wang Y, Fisher K, Johnson J, Chakroff J, Besner GE. Comparison of Different In Vivo Incubation Sites to Produce Tissue-Engineered Small Intestine. Tissue Eng Part A. 2018 Mar 1;
  • Cromeens BP, Wang Y, Liu Y, Johnson J, Besner GE. Critical intestinal cells originate from the host in enteroid-derived tissue-engineered intestine. J Surg Res. 2018 Mar; 223: 155-164.
  • Drucker NA, McCulloh CJ, Li B, Pierro A, Besner GE, Markel TA. Stem cell therapy in necrotizing enterocolitis: Current state and future directions. Semin Pediatr Surg. 2018 Feb; 27: 57-64.
  • Nordin AB, Sales SP, Besner GE, Levitt MA, Wood RJ, Kenney BD. Effective methods to decrease surgical site infections in pediatric gastrointestinal surgery. J Pediatr Surg. 2017 Oct 10;
  • Olson JK, Deming LA, King DR, Rager TM, Gartner S, Huibregtse N, Moss RL, Besner GE. Single visit surgery for pediatric ambulatory surgical procedures: a satisfaction and cost analysis. J Pediatr Surg. 2017 Oct 10;
  • Aldrink JH, Gonzalez DO, Sales SP, Deans KJ, Besner GE, Hewitt GD. Using quality improvement methodology to improve ovarian salvage for benign ovarian masses. J Pediatr Surg. 2017 Oct 10;
  • Shen S, Wang H, Xue Y, Yuan L, Zhou X, Zhao Z, Dong E, Liu B, Liu W, Cromeens B, Adler B, Besner G, Xu RX. Freeform fabrication of tissue-simulating phantom for potential use of surgical planning in conjoined twins separation surgery. Sci Rep. 2017 Sep 8; 7: 11048.
  • Zhou Y, Wang Y, Olson J, Yang J, Besner GE. Heparin-binding EGF-like growth factor promotes neuronal nitric oxide synthase expression and protects the enteric nervous system after necrotizing enterocolitis. Pediatr Res. 2017 Sep; 82: 490-500.
  • Cromeens BP, Ray WC, Hoehne B, Abayneh F, Adler B, Besner GE. Facilitating surgeon understanding of complex anatomy using a three-dimensional printed model. J Surg Res. 2017 Aug; 216: 18-25.
  • McCulloh CJ, Olson JK, Wang Y, Vu J, Gartner S, Besner GE. Evaluating the efficacy of different types of stem cells in preserving gut barrier function in necrotizing enterocolitis. J Surg Res. 2017 Jun 15; 214: 278-285.
  • McCulloh CJ, Olson JK, Zhou Y, Wang Y, Besner GE. Stem cells and necrotizing enterocolitis: A direct comparison of the efficacy of multiple types of stem cells. J Pediatr Surg. 2017 Jun; 52: 999-1005.
  • Cromeens BP, Lisciandro RE, Brilli RJ, Askegard-Giesmann JR, Kenney BD, Besner GE. Identifying Adverse Events in Pediatric Surgery: Comparing Morbidity and Mortality Conference with the NSQIP-Pediatric System. J Am Coll Surg. 2017 May; 224: 945-953.

Education

Date of Appointment at Nationwide Children’s Hospital: 11/26/1991

Board Certifications

Pediatric Surgery Surgery Surgical Critical Care

Fellowship

Boston Children’s Hospital

Date Completed: 06/30/1989

Residency

Children’s Hospital of Buffalo

Date Completed: 06/30/1991

Residency

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1987

Internship

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1983

Medical School

University of Cincinnati

Date Completed: 06/13/1982

Education

Date of Appointment at Nationwide Children’s Hospital: 11/26/1991

Board Certifications

Pediatric Surgery Surgery Surgical Critical Care

Fellowship

Boston Children’s Hospital

Date Completed: 06/30/1989

Residency

Children’s Hospital of Buffalo

Date Completed: 06/30/1991

Residency

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1987

Internship

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1983

Medical School

University of Cincinnati

Date Completed: 06/13/1982

Education

Date of Appointment at Nationwide Children’s Hospital: 11/26/1991

Board Certifications

Pediatric Surgery Surgery Surgical Critical Care

Fellowship

Boston Children’s Hospital

Date Completed: 06/30/1989

Residency

Children’s Hospital of Buffalo

Date Completed: 06/30/1991

Residency

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1987

Internship

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1983

Medical School

University of Cincinnati

Date Completed: 06/13/1982

Date of Appointment at Nationwide Children’s Hospital: 11/26/1991

Board Certifications

Pediatric Surgery Surgery Surgical Critical Care

Fellowship

Boston Children’s Hospital

Date Completed: 06/30/1989

Residency

Children’s Hospital of Buffalo

Date Completed: 06/30/1991

Residency

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1987

Internship

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1983

Medical School

University of Cincinnati

Date Completed: 06/13/1982

Date of Appointment at Nationwide Children’s Hospital: 11/26/1991

Board Certifications

Pediatric Surgery Surgery Surgical Critical Care

Fellowship

Boston Children’s Hospital

Date Completed: 06/30/1989

Residency

Children’s Hospital of Buffalo

Date Completed: 06/30/1991

Residency

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1987

Internship

Harvard - Brigham & Women’s Hospital

Date Completed: 06/30/1983

Medical School

University of Cincinnati

Date Completed: 06/13/1982

  • Pediatric Surgery
  • Surgery
  • Surgical Critical Care

Research Funding

National Institutes of Health Exosomes and HB-EGF in Stem Cell-Mediated Therapy for Necrotizing Enterocolitis, Principal Investigator National Institutes of Health Tuneable Native Probiotic Formulations to Study and Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI) National Institutes of Health Tissue Engineered Intestine, Co-Principal Investigator National Institutes of Health A Novel Probiotic Platform to Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI)

Research Funding

National Institutes of Health Exosomes and HB-EGF in Stem Cell-Mediated Therapy for Necrotizing Enterocolitis, Principal Investigator National Institutes of Health Tuneable Native Probiotic Formulations to Study and Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI) National Institutes of Health Tissue Engineered Intestine, Co-Principal Investigator National Institutes of Health A Novel Probiotic Platform to Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI)

Research Funding

National Institutes of Health Exosomes and HB-EGF in Stem Cell-Mediated Therapy for Necrotizing Enterocolitis, Principal Investigator National Institutes of Health Tuneable Native Probiotic Formulations to Study and Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI) National Institutes of Health Tissue Engineered Intestine, Co-Principal Investigator National Institutes of Health A Novel Probiotic Platform to Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI)

National Institutes of Health Exosomes and HB-EGF in Stem Cell-Mediated Therapy for Necrotizing Enterocolitis, Principal Investigator National Institutes of Health Tuneable Native Probiotic Formulations to Study and Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI) National Institutes of Health Tissue Engineered Intestine, Co-Principal Investigator National Institutes of Health A Novel Probiotic Platform to Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI)

Exosomes and HB-EGF in Stem Cell-Mediated Therapy for Necrotizing Enterocolitis, Principal Investigator

Tuneable Native Probiotic Formulations to Study and Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI)

Tissue Engineered Intestine, Co-Principal Investigator

A Novel Probiotic Platform to Treat Necrotizing Enterocolitis, Principal Investigator (multiple PI)

Contact Information

General Pediatric Surgery

Call us at: (614) 722-3900

Fax us at: (614) 722-3903

                    Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)

Contact Information

General Pediatric Surgery

Call us at: (614) 722-3900

Fax us at: (614) 722-3903

                    Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)

Contact Information

General Pediatric Surgery

Call us at: (614) 722-3900

Fax us at: (614) 722-3903

                    Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)

General Pediatric Surgery

Call us at: (614) 722-3900

Fax us at: (614) 722-3903

                    Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-3900

Fax us at: (614) 722-3903

                    Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-3900

Fax us at: (614) 722-3903

                    Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)
  • Call us at:
  • (614) 722-3900
  • Fax us at:
  • (614) 722-3903
  • Pediatric Surgery700 Children’s DrColumbus, OH 43205 (map)