Daniel R Boue

Contact Information

Call us at: (614) 722-5450

Fax us at: (614) 722-2899

Pathology & Laboratory MedicineLaboratory Medicine/Clinical Pathology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Daniel R. Boue

Biography

Daniel R. Boué, MD, PhD, is an attending staff pathologist in Anatomic and Clinical Pathology, and Director of Neuropathology, within the Department of Pathology and Laboratory Medicine at Nationwide Children’s Hospital; he has an academic appointment as Associate Professor- Clinical, Department of Pathology, The Ohio State University College of Medicine, Columbus, OH. Dr. Boué is the Neuropathology Program Director for Nationwide Children’s Hospital, for OSU/ NCH and other, rotating Pathology, Pediatrics, Neuro-pathology, Neurosurgery, Neuro-oncology, Neurology and Genetics Residents and Fellows) He also is a Review Pathologist/ Co-I, for the Collaborative Human Tissue Network (CHTN) within The Research Institute at Nationwide Children’s Hospital Center for Biopathology, and currently is and has been a central review pathologist for various COG (Children’s Oncology Group) brain tumor study committees/ clinical trials (including high grade gliomas, medulloblastomas, and ependymomas) and is a member of the National Medulloblastoma Reference Laboratory at NCH. He is also a Central Review Pathologist for the NEXT Consortium/ Head Start 4 International Clinical Trial for Medulloblastomas and other CNS Embryonal Tumors, which will soon include similar trials for Choroid Plexus Carcinomas and Ependymomas. He currently serves on the following committees: Institute for Genomic Medicine Epilepsy Genomics; CNS Cancer Predisposition Organizing Committee; Institute for Genomic Medicine Brain Tumor Genomics; Surgical Pathology QA Committee; OSU COM (MD) Admissions Committee and Medical Careers Pathway Post-Baccalaureate Program (MEDPATH) and on the Society for Pediatric Pathology’s Research and Awards Committee; Children’s Oncology Group ACNS1422 Medulloblastoma Study Committee; Children’s Oncology Group ACNS0831 Ependymoma Study Committee; and Children’s Oncology Group Medulloblastoma Reference Laboratory. His particular clinical interests are in the diagnosis of pediatric brain tumors, pediatric neuromuscular diseases, and pediatric hematopathologic conditions. His research interests are in the diagnostic and prognostic features of pediatric brain tumors. He is a co- investigator on various federal and local grants to study pediatric brain tumors and muscle diseases. Particular educational interests are in the teaching of various neuropathology topics to neurosurgery, general surgery, pathology, neurology, and pediatrics residents and medical student trainees.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Academic and Clinical Areas

Pathology Fellowship

Faculty

Pathology and Laboratory Medicine

Anatomic Pathology Team

Anatomic Pathology

Director, Neuropathology

Neuro-Oncology

Physician Team

Clinical Pathology

Pathologist, Clinical Pathology

Clinical Neurophysiology Fellowship

Faculty

Primary Department

Pathology & Laboratory Medicine

Primary Section

Anatomic Pathology

Awards, Honors & Organizations

Member, Alpha Omega Alpha (National) Honor Medical Society, 1990 Listed, Guide to America’s Top Pathologists, Consumers Research Council of America Sheard- Sanford Award, American Society for Clinical Pathology

Research

Publications

                  Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.

                


                  Garcia MR, Feng Y, Vasudevaraja V, Galbraith K, Serrano J, Thomas C, Radmanesh A, Hidalgo ET, Harter DH, Allen JC, Gardner SL, Osorio DS, William CM, Zagzag D, Boué DR, Snuderl M. Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas. J Neuropathol Exp Neurol. 2022 Aug 23;  

                


                  Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;  

                


                  De Faria FW, Schieffer KM, Pierson CR, Boue DR, LaHaye S, Miller KE, Amayiri N, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly B, White P, Magrini V, Wilson RK, Mardis ER, Cottrell CE, Rusin J, Finlay JL, Osorio DS. Infantile metastatic ependymoma with a novel molecular profile and favorable outcome to intensive chemotherapy without irradiation: Case-based review. Genes Chromosomes Cancer. 2022 Jun 18;  

                


                  Guney E, Lucas CG, Qi Z, Yu J, Zhang R, Ohgami RS, Rubenstein JL, Boué DR, Schafernak KT, Wertheim GB, Dahiya S, Giulino-Roth L, Attarbaschi A, Barth MJ, Kothari S, Abla O, Cohen AL, Mendez JS, Bollen AW, Perry A, Tihan T, Pekmezci M, Solomon DA, Wen KW. A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome. Blood Adv. 2022 Feb 14;  

                


                  Miller KE, Wheeler G, LaHaye S, Schieffer KM, Cearlock S, Venkata LPR, Bravo AO, Grischow OE, Kelly BJ, White P, Pierson CR, Boué DR, Koo SC, Klawinski D, Ranalli MA, Shaikhouni A, Salloum R, Shatara M, Leonard JR, Wilson RK, Cottrell CE, Mardis ER, Koboldt DC. Molecular Heterogeneity in Pediatric Malignant Rhabdoid Tumors in Patients With Multi-Organ Involvement. Front Oncol. 2022; 12: 932337.

                


                  Ronsley R, Boué DR, Venkata LPR, Scott S, Shaikhouni A, Jones J, Schieffer KM, Cottrell CE, Mardis ER, Olshefski R, Salloum R, Miller KE. An unusual case of atypical teratoid/rhabdoid tumor, initially diagnosed as atypical pituitary adenoma in a 13-year-old male patient. Neurooncol Adv. 2022 Jan-Dec; 4: vdac121.

                


                  Shatara M, Schieffer KM, Klawinski D, Thomas DL, Pierson CR, Sribnick EA, Jones J, Rodriguez DP, Deeg C, Hamelberg E, LaHaye S, Miller KE, Fitch J, Kelly B, Leraas K, Pfau R, White P, Magrini V, Wilson RK, Mardis ER, Abdelbaki MS, Finlay JL, Boué DR, Cottrell CE, Ghasemi DR, Pajtler KW, Osorio DS. Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas. Acta Neuropathol Commun. 2021 Dec 11; 9: 192.

                


                  LaHaye S, Fitch JR, Voytovich KJ, Herman AC, Kelly BJ, Lammi GE, Arbesfeld JA, Wijeratne S, Franklin SJ, Schieffer KM, Bir N, McGrath SD, Miller AR, Wetzel A, Miller KE, Bedrosian TA, Leraas K, Varga EA, Lee K, Gupta A, Setty B, Boué DR, Leonard JR, Finlay JL, Abdelbaki MS, Osorio DS, Koo SC, Koboldt DC, Wagner AH, Eisfeld AK, Mrózek K, Magrini V, Cottrell CE, Mardis ER, Wilson RK, White P. Discovery of clinically relevant fusions in pediatric cancer. BMC Genomics. 2021 Dec 4; 22: 872.

                


                  Harris MK, Shatara M, Funk Z, Stanek J, Boué DR, Jones J, Finlay JL, Abdelbaki MS. Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature. Childs Nerv Syst. 2021 May 4;  

                


                  Schieffer KM, Feldman AZ, Kautto EA, McGrath S, Miller AR, Hernandez-Gonzalez ME, LaHaye S, Miller KE, Koboldt DC, Brennan P, Kelly B, Wetzel A, Agarwal V, Shatara M, Conley S, Rodriguez DP, Abu-Arja R, Shaikhkhalil A, Snuderl M, Orr BA, Finlay JL, Osorio DS, Drapeau AI, Leonard JR, Pierson CR, White P, Magrini V, Mardis ER, Wilson RK, Cottrell CE, Boué DR. Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma. Acta Neuropathol Commun. 2021 Apr 7; 9: 61.

                


                  Schieffer KM, Agarwal V, LaHaye S, Miller KE, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly BJ, Crist E, Rusin J, Finlay JL, Osorio DS, Sribnick EA, Leonard JR, Feldman A, Orr BA, Serrano J, Vasudevaraja V, Snuderl M, White P, Magrini V, Wilson RK, Mardis ER, Boué DR, Cottrell CE. YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas. Am J Surg Pathol. 2021 Mar 1; 45: 329-340.

                


                  Yankelevich M, Finlay JL, Gorsi H, Kupsky W, Boue DR, Koschmann CJ, Kumar-Sinha C, Mody R. Molecular insights into malignant progression of atypical choroid plexus papilloma. Cold Spring Harb Mol Case Stud. 2021 Feb; 7: 

                


                  Lazow MA, Hoffman L, Schafer A, Osorio DS, Boué DR, Rush S, Wright E, Lane A, DeWire-Schottmiller MD, Smolarek T, Sipple J, Taggert H, Reuss J, Salloum R, Hummel TR, de Blank P, Pillay-Smiley N, Sutton ME, Asher A, Stevenson CB, Drissi R, Finlay JL, Fouladi M, Fuller C. Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas. Acta Neuropathol Commun. 2020 Nov 5; 8: 182.

                


                  Toland A, McNulty SN, Pekmezci M, Evenson M, Huntoon K, Pierson CR, Boue DR, Perry A, Dahiya S. Pediatric meningioma: A clinicopathologic and molecular study with potential grading implications. Brain Pathol. 2020 Jul 27;  

                


                  Tang K, Kurland D, Vasudevaraja V, Serrano J, Delorenzo M, Radmanesh A, Thomas C, Spino M, Gardner S, Allen JC, Nicolaides T, Osorio DS, Finlay JL, Boué DR, Snuderl M. Exploring DNA Methylation for Prognosis and Analyzing the Tumor Microenvironment in Pleomorphic Xanthoastrocytoma. J Neuropathol Exp Neurol. 2020 Jun 28;  

                


                  Liu H, Guinipero TL, Schieffer KM, Carter C, Colace S, Leonard JR, Orr BA, Kahwash SB, Brennan PJ, Fitch JR, Kelly B, Magrini VJ, White P, Wilson RK, Mardis ER, Cottrell CE, Boué DR. De novo primary central nervous system pure erythroid leukemia/sarcoma with t(1;16)(p31;q24) NFIA/CBFA2T3 translocation. Haematologica. 2020 Apr; 105: e194-e197.

                


                  Kanchan RK, Perumal N, Atri P, Chirravuri Venkata R, Thapa I, Klinkebiel DL, Donson AM, Perry D, Punsoni M, Talmon GA, Coulter DW, Boue' DR, Snuderl M, Nasser MW, Batra SK, Vibhakar R, Mahapatra S. MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3). Brain Pathol. 2020 Mar 7;  

                


                  Nobre L, Zapotocky M, Ramaswamy V, Ryall S, Bennett J, Alderete D, Balaguer Guill J, Baroni L, Bartels U, Bavle A, Bornhorst M, Boue DR, Canete A, Chintagumpala M, Coven SL, Cruz O, Dahiya S, Dirks P, Dunkel IJ, Eisenstat D, Faure Conter C, Finch E, Finlay JL, Frappaz D, Garre ML, Gauvain K, Bechensteen AG, Hansford JR, Harting I, Hauser P, Hazrati LN, Huang A, Injac SG, Iurilli V, Karajannis M, Kaur G, Kyncl M, Krskova L, Laperriere N, Larouche V, Lassaletta A, Leary S, Lin F, Mascelli S, McKeown T, Milde T, Morales La Madrid A, Morana G, Morse H, Mushtaq N, Osorio DS, Packer R, Pavelka Z, Quiroga-Cantero E, Rutka J, Sabel M, Salgado D, Solano P, Sterba J, Su J, Sumerauer D, Taylor MD, Toledano H, Tsang DS, Valente Fernandes M, van Landeghem F, van Tilburg CM, Wilson B, Witt O, Zamecnik J, Bouffet E, Hawkins C, Tabori U. Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition. JCO Precis Oncol. 2020; 4: 

                


                  Richardson TE, Tang K, Vasudevaraja V, Serrano J, William CM, Mirchia K, Pierson CR, Leonard JR, AbdelBaki MS, Schieffer KM, Cottrell CE, Tovar-Spinoza Z, Comito MA, Boué DR, Jour G, Snuderl M. GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors. J Neuropathol Exp Neurol. 2019 Dec 1; 78: 1089-1099.

                


                  Waldrop M, Amornvit J, Pierson CR, Boue DR, Sahenk Z. A Novel De Novo Heterozygous SCN4a Mutation Causing Congenital Myopathy, Myotonia and Multiple Congenital Anomalies. J Neuromuscul Dis. 2019 Oct 8;  

                


                  Guerreiro Stucklin AS, Ryall S, Fukuoka K, Zapotocky M, Lassaletta A, Li C, Bridge T, Kim B, Arnoldo A, Kowalski PE, Zhong Y, Johnson M, Li C, Ramani AK, Siddaway R, Nobre LF, de Antonellis P, Dunham C, Cheng S, Boué DR, Finlay JL, Coven SL, de Prada I, Perez-Somarriba M, Faria CC, Grotzer MA, Rushing E, Sumerauer D, Zamecnik J, Krskova L, Garcia Ariza M, Cruz O, Morales La Madrid A, Solano P, Terashima K, Nakano Y, Ichimura K, Nagane M, Sakamoto H, Gil-da-Costa MJ, Silva R, Johnston DL, Michaud J, Wilson B, van Landeghem FKH, Oviedo A, McNeely PD, Crooks B, Fried I, Zhukova N, Hansford JR, Nageswararao A, Garzia L, Shago M, Brudno M, Irwin MS, Bartels U, Ramaswamy V, Bouffet E, Taylor MD, Tabori U, Hawkins C. Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nat Commun. 2019 Sep 25; 10: 4343.

                


                  Chiang JCH, Harreld JH, Tanaka R, Li X, Wen J, Zhang C, Boué DR, Rauch TM, Boyd JT, Chen J, Corbo JC, Bouldin TW, Elton SW, Liu LL, Schofield D, Lee SC, Bouffard JP, Georgescu MM, Dossani RH, Aguiar MA, Sances RA, Saad AG, Boop FA, Qaddoumi I, Ellison DW. Septal Dysembryoplastic Neuroepithelial Tumor: A Comprehensive Clinical, Imaging, Histopathologic and Molecular Analysis. Neuro Oncol. 2019 Feb 6;  

                


                  Abu Arja MH, Stalling M, Governale LS, Pierson CR, Rusin JA, Palmer JD, Finlay JL, Olshefski R, Boué DR. Germinoma Involving the Retina: An Unusual Presentation of Recurrent Intracranial Mixed Germ Cell Tumor. World Neurosurg. 2019 Jan 7;  

                


                  AbdelBaki MS, Boué DR, Finlay JL, Kieran MW. Desmoplastic nodular medulloblastoma in young children: a management dilemma. Neuro Oncol. 2018 Jul 5; 20: 1026-1033.

                


                  Waldrop MA, Gumienny F, Boue D, de Los Reyes E, Shell R, Weiss RB, Flanigan KM. Low-level expression of EPG5 leads to an attenuated Vici syndrome phenotype. Am J Med Genet A. 2018 May; 176: 1207-1211.

                


                  Miller KE, Kelly B, Fitch J, Ross N, Avenarius MR, Varga E, Koboldt DC, Boué DR, Magrini V, Coven SL, Finlay JL, Cottrell CE, White P, Gastier-Foster JM, Wilson RK, Leonard J, Mardis ER. Genome sequencing identifies somatic BRAF duplication c.1794_1796dupTAC;p.Thr599dup in pediatric patient with low-grade ganglioglioma. Cold Spring Harb Mol Case Stud. 2018 Apr; 4: 

                


                  Abu Arja MH, Conley SE, Salceda V, Al-Sufiani F, Boué DR, Finlay JL. Brentuximab-vedotin maintenance following chemotherapy without irradiation for primary intracranial embryonal carcinoma in down syndrome. Childs Nerv Syst. 2018 Apr; 34: 777-780.

                


                  Salloum R, McConechy MK, Mikael LG, Fuller C, Drissi R, DeWire M, Nikbakht H, De Jay N, Yang X, Boue D, Chow LML, Finlay JL, Gayden T, Karamchandani J, Hummel TR, Olshefski R, Osorio DS, Stevenson C, Kleinman CL, Majewski J, Fouladi M, Jabado N. Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. Acta Neuropathol Commun. 2017 Oct 30; 5: 78.

                


                  Chin Tan G, Stalling M, Boue D, Pyle-Eilola A, Kahwash SB. That's Not Supposed to Be There: An Unusual Finding on Urinalysis. Clin Chem. 2017 Oct; 63: 1660-1661.

                


                  Waldrop MA, Boue DR, Sites E, Flanigan KM, Shell R. Clinicopathologic Conference: A Newborn With Hypotonia, Cleft Palate, Micrognathia, and Bilateral Club Feet. Pediatr Neurol. 2017 Sep; 74: 11-14.

                


                  Huntoon K, Pluto CP, Ruess L, Boué DR, Pierson CR, Rusin JA, Leonard J. Sporadic pediatric meningiomas: a neuroradiological and neuropathological study of 15 cases. J Neurosurg Pediatr. 2017 Aug; 20: 141-148.

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Education

Date of Appointment at Nationwide Children’s Hospital: 06/17/1997

Board Certifications

Anatomic Pathology Clinical Pathology Pediatric Pathology

Fellowship

Nationwide Children’s Hospital

Date Completed: 01/05/1997

Fellowship

Nationwide Children’s Hospital

Date Completed: 12/31/1996

Residency

University of California San Diego Medical Center

Date Completed: 06/30/1995

Internship

University of California San Diego Medical Center

Date Completed: 06/30/1992

Medical School

University of Minnesota

Date Completed: 06/08/1991

Research Funding

National Childhood Cancer Foundation/NIH/ NCI Children’s Oncology Group/Bio-Pathology Center, Other National Childhood Cancer Foundation/COG/NIH/NCI Children’s Oncology Group/Bio-pathology Center/Specimen Banking, Other

Contact Information

Pathology & Laboratory Medicine

Call us at: (614) 722-5450

Fax us at: (614) 722-2899

                    Laboratory Medicine/Clinical Pathology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-5450

Fax us at: (614) 722-2899

Pathology & Laboratory MedicineLaboratory Medicine/Clinical Pathology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Daniel R. Boue

Biography

Daniel R. Boué, MD, PhD, is an attending staff pathologist in Anatomic and Clinical Pathology, and Director of Neuropathology, within the Department of Pathology and Laboratory Medicine at Nationwide Children’s Hospital; he has an academic appointment as Associate Professor- Clinical, Department of Pathology, The Ohio State University College of Medicine, Columbus, OH. Dr. Boué is the Neuropathology Program Director for Nationwide Children’s Hospital, for OSU/ NCH and other, rotating Pathology, Pediatrics, Neuro-pathology, Neurosurgery, Neuro-oncology, Neurology and Genetics Residents and Fellows) He also is a Review Pathologist/ Co-I, for the Collaborative Human Tissue Network (CHTN) within The Research Institute at Nationwide Children’s Hospital Center for Biopathology, and currently is and has been a central review pathologist for various COG (Children’s Oncology Group) brain tumor study committees/ clinical trials (including high grade gliomas, medulloblastomas, and ependymomas) and is a member of the National Medulloblastoma Reference Laboratory at NCH. He is also a Central Review Pathologist for the NEXT Consortium/ Head Start 4 International Clinical Trial for Medulloblastomas and other CNS Embryonal Tumors, which will soon include similar trials for Choroid Plexus Carcinomas and Ependymomas. He currently serves on the following committees: Institute for Genomic Medicine Epilepsy Genomics; CNS Cancer Predisposition Organizing Committee; Institute for Genomic Medicine Brain Tumor Genomics; Surgical Pathology QA Committee; OSU COM (MD) Admissions Committee and Medical Careers Pathway Post-Baccalaureate Program (MEDPATH) and on the Society for Pediatric Pathology’s Research and Awards Committee; Children’s Oncology Group ACNS1422 Medulloblastoma Study Committee; Children’s Oncology Group ACNS0831 Ependymoma Study Committee; and Children’s Oncology Group Medulloblastoma Reference Laboratory. His particular clinical interests are in the diagnosis of pediatric brain tumors, pediatric neuromuscular diseases, and pediatric hematopathologic conditions. His research interests are in the diagnostic and prognostic features of pediatric brain tumors. He is a co- investigator on various federal and local grants to study pediatric brain tumors and muscle diseases. Particular educational interests are in the teaching of various neuropathology topics to neurosurgery, general surgery, pathology, neurology, and pediatrics residents and medical student trainees.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Academic and Clinical Areas

Pathology Fellowship

Faculty

Pathology and Laboratory Medicine

Anatomic Pathology Team

Anatomic Pathology

Director, Neuropathology

Neuro-Oncology

Physician Team

Clinical Pathology

Pathologist, Clinical Pathology

Clinical Neurophysiology Fellowship

Faculty

Primary Department

Pathology & Laboratory Medicine

Primary Section

Anatomic Pathology

Awards, Honors & Organizations

Member, Alpha Omega Alpha (National) Honor Medical Society, 1990 Listed, Guide to America’s Top Pathologists, Consumers Research Council of America Sheard- Sanford Award, American Society for Clinical Pathology

Research

Publications

                  Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.

                


                  Garcia MR, Feng Y, Vasudevaraja V, Galbraith K, Serrano J, Thomas C, Radmanesh A, Hidalgo ET, Harter DH, Allen JC, Gardner SL, Osorio DS, William CM, Zagzag D, Boué DR, Snuderl M. Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas. J Neuropathol Exp Neurol. 2022 Aug 23;  

                


                  Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;  

                


                  De Faria FW, Schieffer KM, Pierson CR, Boue DR, LaHaye S, Miller KE, Amayiri N, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly B, White P, Magrini V, Wilson RK, Mardis ER, Cottrell CE, Rusin J, Finlay JL, Osorio DS. Infantile metastatic ependymoma with a novel molecular profile and favorable outcome to intensive chemotherapy without irradiation: Case-based review. Genes Chromosomes Cancer. 2022 Jun 18;  

                


                  Guney E, Lucas CG, Qi Z, Yu J, Zhang R, Ohgami RS, Rubenstein JL, Boué DR, Schafernak KT, Wertheim GB, Dahiya S, Giulino-Roth L, Attarbaschi A, Barth MJ, Kothari S, Abla O, Cohen AL, Mendez JS, Bollen AW, Perry A, Tihan T, Pekmezci M, Solomon DA, Wen KW. A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome. Blood Adv. 2022 Feb 14;  

                


                  Miller KE, Wheeler G, LaHaye S, Schieffer KM, Cearlock S, Venkata LPR, Bravo AO, Grischow OE, Kelly BJ, White P, Pierson CR, Boué DR, Koo SC, Klawinski D, Ranalli MA, Shaikhouni A, Salloum R, Shatara M, Leonard JR, Wilson RK, Cottrell CE, Mardis ER, Koboldt DC. Molecular Heterogeneity in Pediatric Malignant Rhabdoid Tumors in Patients With Multi-Organ Involvement. Front Oncol. 2022; 12: 932337.

                


                  Ronsley R, Boué DR, Venkata LPR, Scott S, Shaikhouni A, Jones J, Schieffer KM, Cottrell CE, Mardis ER, Olshefski R, Salloum R, Miller KE. An unusual case of atypical teratoid/rhabdoid tumor, initially diagnosed as atypical pituitary adenoma in a 13-year-old male patient. Neurooncol Adv. 2022 Jan-Dec; 4: vdac121.

                


                  Shatara M, Schieffer KM, Klawinski D, Thomas DL, Pierson CR, Sribnick EA, Jones J, Rodriguez DP, Deeg C, Hamelberg E, LaHaye S, Miller KE, Fitch J, Kelly B, Leraas K, Pfau R, White P, Magrini V, Wilson RK, Mardis ER, Abdelbaki MS, Finlay JL, Boué DR, Cottrell CE, Ghasemi DR, Pajtler KW, Osorio DS. Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas. Acta Neuropathol Commun. 2021 Dec 11; 9: 192.

                


                  LaHaye S, Fitch JR, Voytovich KJ, Herman AC, Kelly BJ, Lammi GE, Arbesfeld JA, Wijeratne S, Franklin SJ, Schieffer KM, Bir N, McGrath SD, Miller AR, Wetzel A, Miller KE, Bedrosian TA, Leraas K, Varga EA, Lee K, Gupta A, Setty B, Boué DR, Leonard JR, Finlay JL, Abdelbaki MS, Osorio DS, Koo SC, Koboldt DC, Wagner AH, Eisfeld AK, Mrózek K, Magrini V, Cottrell CE, Mardis ER, Wilson RK, White P. Discovery of clinically relevant fusions in pediatric cancer. BMC Genomics. 2021 Dec 4; 22: 872.

                


                  Harris MK, Shatara M, Funk Z, Stanek J, Boué DR, Jones J, Finlay JL, Abdelbaki MS. Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature. Childs Nerv Syst. 2021 May 4;  

                


                  Schieffer KM, Feldman AZ, Kautto EA, McGrath S, Miller AR, Hernandez-Gonzalez ME, LaHaye S, Miller KE, Koboldt DC, Brennan P, Kelly B, Wetzel A, Agarwal V, Shatara M, Conley S, Rodriguez DP, Abu-Arja R, Shaikhkhalil A, Snuderl M, Orr BA, Finlay JL, Osorio DS, Drapeau AI, Leonard JR, Pierson CR, White P, Magrini V, Mardis ER, Wilson RK, Cottrell CE, Boué DR. Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma. Acta Neuropathol Commun. 2021 Apr 7; 9: 61.

                


                  Schieffer KM, Agarwal V, LaHaye S, Miller KE, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly BJ, Crist E, Rusin J, Finlay JL, Osorio DS, Sribnick EA, Leonard JR, Feldman A, Orr BA, Serrano J, Vasudevaraja V, Snuderl M, White P, Magrini V, Wilson RK, Mardis ER, Boué DR, Cottrell CE. YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas. Am J Surg Pathol. 2021 Mar 1; 45: 329-340.

                


                  Yankelevich M, Finlay JL, Gorsi H, Kupsky W, Boue DR, Koschmann CJ, Kumar-Sinha C, Mody R. Molecular insights into malignant progression of atypical choroid plexus papilloma. Cold Spring Harb Mol Case Stud. 2021 Feb; 7: 

                


                  Lazow MA, Hoffman L, Schafer A, Osorio DS, Boué DR, Rush S, Wright E, Lane A, DeWire-Schottmiller MD, Smolarek T, Sipple J, Taggert H, Reuss J, Salloum R, Hummel TR, de Blank P, Pillay-Smiley N, Sutton ME, Asher A, Stevenson CB, Drissi R, Finlay JL, Fouladi M, Fuller C. Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas. Acta Neuropathol Commun. 2020 Nov 5; 8: 182.

                


                  Toland A, McNulty SN, Pekmezci M, Evenson M, Huntoon K, Pierson CR, Boue DR, Perry A, Dahiya S. Pediatric meningioma: A clinicopathologic and molecular study with potential grading implications. Brain Pathol. 2020 Jul 27;  

                


                  Tang K, Kurland D, Vasudevaraja V, Serrano J, Delorenzo M, Radmanesh A, Thomas C, Spino M, Gardner S, Allen JC, Nicolaides T, Osorio DS, Finlay JL, Boué DR, Snuderl M. Exploring DNA Methylation for Prognosis and Analyzing the Tumor Microenvironment in Pleomorphic Xanthoastrocytoma. J Neuropathol Exp Neurol. 2020 Jun 28;  

                


                  Liu H, Guinipero TL, Schieffer KM, Carter C, Colace S, Leonard JR, Orr BA, Kahwash SB, Brennan PJ, Fitch JR, Kelly B, Magrini VJ, White P, Wilson RK, Mardis ER, Cottrell CE, Boué DR. De novo primary central nervous system pure erythroid leukemia/sarcoma with t(1;16)(p31;q24) NFIA/CBFA2T3 translocation. Haematologica. 2020 Apr; 105: e194-e197.

                


                  Kanchan RK, Perumal N, Atri P, Chirravuri Venkata R, Thapa I, Klinkebiel DL, Donson AM, Perry D, Punsoni M, Talmon GA, Coulter DW, Boue' DR, Snuderl M, Nasser MW, Batra SK, Vibhakar R, Mahapatra S. MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3). Brain Pathol. 2020 Mar 7;  

                


                  Nobre L, Zapotocky M, Ramaswamy V, Ryall S, Bennett J, Alderete D, Balaguer Guill J, Baroni L, Bartels U, Bavle A, Bornhorst M, Boue DR, Canete A, Chintagumpala M, Coven SL, Cruz O, Dahiya S, Dirks P, Dunkel IJ, Eisenstat D, Faure Conter C, Finch E, Finlay JL, Frappaz D, Garre ML, Gauvain K, Bechensteen AG, Hansford JR, Harting I, Hauser P, Hazrati LN, Huang A, Injac SG, Iurilli V, Karajannis M, Kaur G, Kyncl M, Krskova L, Laperriere N, Larouche V, Lassaletta A, Leary S, Lin F, Mascelli S, McKeown T, Milde T, Morales La Madrid A, Morana G, Morse H, Mushtaq N, Osorio DS, Packer R, Pavelka Z, Quiroga-Cantero E, Rutka J, Sabel M, Salgado D, Solano P, Sterba J, Su J, Sumerauer D, Taylor MD, Toledano H, Tsang DS, Valente Fernandes M, van Landeghem F, van Tilburg CM, Wilson B, Witt O, Zamecnik J, Bouffet E, Hawkins C, Tabori U. Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition. JCO Precis Oncol. 2020; 4: 

                


                  Richardson TE, Tang K, Vasudevaraja V, Serrano J, William CM, Mirchia K, Pierson CR, Leonard JR, AbdelBaki MS, Schieffer KM, Cottrell CE, Tovar-Spinoza Z, Comito MA, Boué DR, Jour G, Snuderl M. GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors. J Neuropathol Exp Neurol. 2019 Dec 1; 78: 1089-1099.

                


                  Waldrop M, Amornvit J, Pierson CR, Boue DR, Sahenk Z. A Novel De Novo Heterozygous SCN4a Mutation Causing Congenital Myopathy, Myotonia and Multiple Congenital Anomalies. J Neuromuscul Dis. 2019 Oct 8;  

                


                  Guerreiro Stucklin AS, Ryall S, Fukuoka K, Zapotocky M, Lassaletta A, Li C, Bridge T, Kim B, Arnoldo A, Kowalski PE, Zhong Y, Johnson M, Li C, Ramani AK, Siddaway R, Nobre LF, de Antonellis P, Dunham C, Cheng S, Boué DR, Finlay JL, Coven SL, de Prada I, Perez-Somarriba M, Faria CC, Grotzer MA, Rushing E, Sumerauer D, Zamecnik J, Krskova L, Garcia Ariza M, Cruz O, Morales La Madrid A, Solano P, Terashima K, Nakano Y, Ichimura K, Nagane M, Sakamoto H, Gil-da-Costa MJ, Silva R, Johnston DL, Michaud J, Wilson B, van Landeghem FKH, Oviedo A, McNeely PD, Crooks B, Fried I, Zhukova N, Hansford JR, Nageswararao A, Garzia L, Shago M, Brudno M, Irwin MS, Bartels U, Ramaswamy V, Bouffet E, Taylor MD, Tabori U, Hawkins C. Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nat Commun. 2019 Sep 25; 10: 4343.

                


                  Chiang JCH, Harreld JH, Tanaka R, Li X, Wen J, Zhang C, Boué DR, Rauch TM, Boyd JT, Chen J, Corbo JC, Bouldin TW, Elton SW, Liu LL, Schofield D, Lee SC, Bouffard JP, Georgescu MM, Dossani RH, Aguiar MA, Sances RA, Saad AG, Boop FA, Qaddoumi I, Ellison DW. Septal Dysembryoplastic Neuroepithelial Tumor: A Comprehensive Clinical, Imaging, Histopathologic and Molecular Analysis. Neuro Oncol. 2019 Feb 6;  

                


                  Abu Arja MH, Stalling M, Governale LS, Pierson CR, Rusin JA, Palmer JD, Finlay JL, Olshefski R, Boué DR. Germinoma Involving the Retina: An Unusual Presentation of Recurrent Intracranial Mixed Germ Cell Tumor. World Neurosurg. 2019 Jan 7;  

                


                  AbdelBaki MS, Boué DR, Finlay JL, Kieran MW. Desmoplastic nodular medulloblastoma in young children: a management dilemma. Neuro Oncol. 2018 Jul 5; 20: 1026-1033.

                


                  Waldrop MA, Gumienny F, Boue D, de Los Reyes E, Shell R, Weiss RB, Flanigan KM. Low-level expression of EPG5 leads to an attenuated Vici syndrome phenotype. Am J Med Genet A. 2018 May; 176: 1207-1211.

                


                  Miller KE, Kelly B, Fitch J, Ross N, Avenarius MR, Varga E, Koboldt DC, Boué DR, Magrini V, Coven SL, Finlay JL, Cottrell CE, White P, Gastier-Foster JM, Wilson RK, Leonard J, Mardis ER. Genome sequencing identifies somatic BRAF duplication c.1794_1796dupTAC;p.Thr599dup in pediatric patient with low-grade ganglioglioma. Cold Spring Harb Mol Case Stud. 2018 Apr; 4: 

                


                  Abu Arja MH, Conley SE, Salceda V, Al-Sufiani F, Boué DR, Finlay JL. Brentuximab-vedotin maintenance following chemotherapy without irradiation for primary intracranial embryonal carcinoma in down syndrome. Childs Nerv Syst. 2018 Apr; 34: 777-780.

                


                  Salloum R, McConechy MK, Mikael LG, Fuller C, Drissi R, DeWire M, Nikbakht H, De Jay N, Yang X, Boue D, Chow LML, Finlay JL, Gayden T, Karamchandani J, Hummel TR, Olshefski R, Osorio DS, Stevenson C, Kleinman CL, Majewski J, Fouladi M, Jabado N. Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. Acta Neuropathol Commun. 2017 Oct 30; 5: 78.

                


                  Chin Tan G, Stalling M, Boue D, Pyle-Eilola A, Kahwash SB. That's Not Supposed to Be There: An Unusual Finding on Urinalysis. Clin Chem. 2017 Oct; 63: 1660-1661.

                


                  Waldrop MA, Boue DR, Sites E, Flanigan KM, Shell R. Clinicopathologic Conference: A Newborn With Hypotonia, Cleft Palate, Micrognathia, and Bilateral Club Feet. Pediatr Neurol. 2017 Sep; 74: 11-14.

                


                  Huntoon K, Pluto CP, Ruess L, Boué DR, Pierson CR, Rusin JA, Leonard J. Sporadic pediatric meningiomas: a neuroradiological and neuropathological study of 15 cases. J Neurosurg Pediatr. 2017 Aug; 20: 141-148.

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 06/17/1997

Board Certifications

Anatomic Pathology Clinical Pathology Pediatric Pathology

Fellowship

Nationwide Children’s Hospital

Date Completed: 01/05/1997

Fellowship

Nationwide Children’s Hospital

Date Completed: 12/31/1996

Residency

University of California San Diego Medical Center

Date Completed: 06/30/1995

Internship

University of California San Diego Medical Center

Date Completed: 06/30/1992

Medical School

University of Minnesota

Date Completed: 06/08/1991

Research Funding

National Childhood Cancer Foundation/NIH/ NCI Children’s Oncology Group/Bio-Pathology Center, Other National Childhood Cancer Foundation/COG/NIH/NCI Children’s Oncology Group/Bio-pathology Center/Specimen Banking, Other

Contact Information

Pathology & Laboratory Medicine

Call us at: (614) 722-5450

Fax us at: (614) 722-2899

                    Laboratory Medicine/Clinical Pathology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-5450

Fax us at: (614) 722-2899

Pathology & Laboratory MedicineLaboratory Medicine/Clinical Pathology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Daniel R. Boue

Contact Information

• Call us at:
• (614) 722-5450
• Fax us at:
• (614) 722-2899
• Pathology & Laboratory MedicineLaboratory Medicine/Clinical Pathology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Daniel R. Boue

Biography

Daniel R. Boué, MD, PhD, is an attending staff pathologist in Anatomic and Clinical Pathology, and Director of Neuropathology, within the Department of Pathology and Laboratory Medicine at Nationwide Children’s Hospital; he has an academic appointment as Associate Professor- Clinical, Department of Pathology, The Ohio State University College of Medicine, Columbus, OH. Dr. Boué is the Neuropathology Program Director for Nationwide Children’s Hospital, for OSU/ NCH and other, rotating Pathology, Pediatrics, Neuro-pathology, Neurosurgery, Neuro-oncology, Neurology and Genetics Residents and Fellows) He also is a Review Pathologist/ Co-I, for the Collaborative Human Tissue Network (CHTN) within The Research Institute at Nationwide Children’s Hospital Center for Biopathology, and currently is and has been a central review pathologist for various COG (Children’s Oncology Group) brain tumor study committees/ clinical trials (including high grade gliomas, medulloblastomas, and ependymomas) and is a member of the National Medulloblastoma Reference Laboratory at NCH. He is also a Central Review Pathologist for the NEXT Consortium/ Head Start 4 International Clinical Trial for Medulloblastomas and other CNS Embryonal Tumors, which will soon include similar trials for Choroid Plexus Carcinomas and Ependymomas. He currently serves on the following committees: Institute for Genomic Medicine Epilepsy Genomics; CNS Cancer Predisposition Organizing Committee; Institute for Genomic Medicine Brain Tumor Genomics; Surgical Pathology QA Committee; OSU COM (MD) Admissions Committee and Medical Careers Pathway Post-Baccalaureate Program (MEDPATH) and on the Society for Pediatric Pathology’s Research and Awards Committee; Children’s Oncology Group ACNS1422 Medulloblastoma Study Committee; Children’s Oncology Group ACNS0831 Ependymoma Study Committee; and Children’s Oncology Group Medulloblastoma Reference Laboratory. His particular clinical interests are in the diagnosis of pediatric brain tumors, pediatric neuromuscular diseases, and pediatric hematopathologic conditions. His research interests are in the diagnostic and prognostic features of pediatric brain tumors. He is a co- investigator on various federal and local grants to study pediatric brain tumors and muscle diseases. Particular educational interests are in the teaching of various neuropathology topics to neurosurgery, general surgery, pathology, neurology, and pediatrics residents and medical student trainees.

Biography

Daniel R. Boué, MD, PhD, is an attending staff pathologist in Anatomic and Clinical Pathology, and Director of Neuropathology, within the Department of Pathology and Laboratory Medicine at Nationwide Children’s Hospital; he has an academic appointment as Associate Professor- Clinical, Department of Pathology, The Ohio State University College of Medicine, Columbus, OH. Dr. Boué is the Neuropathology Program Director for Nationwide Children’s Hospital, for OSU/ NCH and other, rotating Pathology, Pediatrics, Neuro-pathology, Neurosurgery, Neuro-oncology, Neurology and Genetics Residents and Fellows) He also is a Review Pathologist/ Co-I, for the Collaborative Human Tissue Network (CHTN) within The Research Institute at Nationwide Children’s Hospital Center for Biopathology, and currently is and has been a central review pathologist for various COG (Children’s Oncology Group) brain tumor study committees/ clinical trials (including high grade gliomas, medulloblastomas, and ependymomas) and is a member of the National Medulloblastoma Reference Laboratory at NCH. He is also a Central Review Pathologist for the NEXT Consortium/ Head Start 4 International Clinical Trial for Medulloblastomas and other CNS Embryonal Tumors, which will soon include similar trials for Choroid Plexus Carcinomas and Ependymomas. He currently serves on the following committees: Institute for Genomic Medicine Epilepsy Genomics; CNS Cancer Predisposition Organizing Committee; Institute for Genomic Medicine Brain Tumor Genomics; Surgical Pathology QA Committee; OSU COM (MD) Admissions Committee and Medical Careers Pathway Post-Baccalaureate Program (MEDPATH) and on the Society for Pediatric Pathology’s Research and Awards Committee; Children’s Oncology Group ACNS1422 Medulloblastoma Study Committee; Children’s Oncology Group ACNS0831 Ependymoma Study Committee; and Children’s Oncology Group Medulloblastoma Reference Laboratory. His particular clinical interests are in the diagnosis of pediatric brain tumors, pediatric neuromuscular diseases, and pediatric hematopathologic conditions. His research interests are in the diagnostic and prognostic features of pediatric brain tumors. He is a co- investigator on various federal and local grants to study pediatric brain tumors and muscle diseases. Particular educational interests are in the teaching of various neuropathology topics to neurosurgery, general surgery, pathology, neurology, and pediatrics residents and medical student trainees.

Biography

Daniel R. Boué, MD, PhD, is an attending staff pathologist in Anatomic and Clinical Pathology, and Director of Neuropathology, within the Department of Pathology and Laboratory Medicine at Nationwide Children’s Hospital; he has an academic appointment as Associate Professor- Clinical, Department of Pathology, The Ohio State University College of Medicine, Columbus, OH. Dr. Boué is the Neuropathology Program Director for Nationwide Children’s Hospital, for OSU/ NCH and other, rotating Pathology, Pediatrics, Neuro-pathology, Neurosurgery, Neuro-oncology, Neurology and Genetics Residents and Fellows) He also is a Review Pathologist/ Co-I, for the Collaborative Human Tissue Network (CHTN) within The Research Institute at Nationwide Children’s Hospital Center for Biopathology, and currently is and has been a central review pathologist for various COG (Children’s Oncology Group) brain tumor study committees/ clinical trials (including high grade gliomas, medulloblastomas, and ependymomas) and is a member of the National Medulloblastoma Reference Laboratory at NCH. He is also a Central Review Pathologist for the NEXT Consortium/ Head Start 4 International Clinical Trial for Medulloblastomas and other CNS Embryonal Tumors, which will soon include similar trials for Choroid Plexus Carcinomas and Ependymomas. He currently serves on the following committees: Institute for Genomic Medicine Epilepsy Genomics; CNS Cancer Predisposition Organizing Committee; Institute for Genomic Medicine Brain Tumor Genomics; Surgical Pathology QA Committee; OSU COM (MD) Admissions Committee and Medical Careers Pathway Post-Baccalaureate Program (MEDPATH) and on the Society for Pediatric Pathology’s Research and Awards Committee; Children’s Oncology Group ACNS1422 Medulloblastoma Study Committee; Children’s Oncology Group ACNS0831 Ependymoma Study Committee; and Children’s Oncology Group Medulloblastoma Reference Laboratory. His particular clinical interests are in the diagnosis of pediatric brain tumors, pediatric neuromuscular diseases, and pediatric hematopathologic conditions. His research interests are in the diagnostic and prognostic features of pediatric brain tumors. He is a co- investigator on various federal and local grants to study pediatric brain tumors and muscle diseases. Particular educational interests are in the teaching of various neuropathology topics to neurosurgery, general surgery, pathology, neurology, and pediatrics residents and medical student trainees.

Daniel R. Boué, MD, PhD, is an attending staff pathologist in Anatomic and Clinical Pathology, and Director of Neuropathology, within the Department of Pathology and Laboratory Medicine at Nationwide Children’s Hospital; he has an academic appointment as Associate Professor- Clinical, Department of Pathology, The Ohio State University College of Medicine, Columbus, OH. Dr. Boué is the Neuropathology Program Director for Nationwide Children’s Hospital, for OSU/ NCH and other, rotating Pathology, Pediatrics, Neuro-pathology, Neurosurgery, Neuro-oncology, Neurology and Genetics Residents and Fellows) He also is a Review Pathologist/ Co-I, for the Collaborative Human Tissue Network (CHTN) within The Research Institute at Nationwide Children’s Hospital Center for Biopathology, and currently is and has been a central review pathologist for various COG (Children’s Oncology Group) brain tumor study committees/ clinical trials (including high grade gliomas, medulloblastomas, and ependymomas) and is a member of the National Medulloblastoma Reference Laboratory at NCH. He is also a Central Review Pathologist for the NEXT Consortium/ Head Start 4 International Clinical Trial for Medulloblastomas and other CNS Embryonal Tumors, which will soon include similar trials for Choroid Plexus Carcinomas and Ependymomas. He currently serves on the following committees: Institute for Genomic Medicine Epilepsy Genomics; CNS Cancer Predisposition Organizing Committee; Institute for Genomic Medicine Brain Tumor Genomics; Surgical Pathology QA Committee; OSU COM (MD) Admissions Committee and Medical Careers Pathway Post-Baccalaureate Program (MEDPATH) and on the Society for Pediatric Pathology’s Research and Awards Committee; Children’s Oncology Group ACNS1422 Medulloblastoma Study Committee; Children’s Oncology Group ACNS0831 Ependymoma Study Committee; and Children’s Oncology Group Medulloblastoma Reference Laboratory. His particular clinical interests are in the diagnosis of pediatric brain tumors, pediatric neuromuscular diseases, and pediatric hematopathologic conditions. His research interests are in the diagnostic and prognostic features of pediatric brain tumors. He is a co- investigator on various federal and local grants to study pediatric brain tumors and muscle diseases. Particular educational interests are in the teaching of various neuropathology topics to neurosurgery, general surgery, pathology, neurology, and pediatrics residents and medical student trainees.

Daniel R. Boué, MD, PhD, is an attending staff pathologist in Anatomic and Clinical Pathology, and Director of Neuropathology, within the Department of Pathology and Laboratory Medicine at Nationwide Children’s Hospital; he has an academic appointment as Associate Professor- Clinical, Department of Pathology, The Ohio State University College of Medicine, Columbus, OH. Dr. Boué is the Neuropathology Program Director for Nationwide Children’s Hospital, for OSU/ NCH and other, rotating Pathology, Pediatrics, Neuro-pathology, Neurosurgery, Neuro-oncology, Neurology and Genetics Residents and Fellows) He also is a Review Pathologist/ Co-I, for the Collaborative Human Tissue Network (CHTN) within The Research Institute at Nationwide Children’s Hospital Center for Biopathology, and currently is and has been a central review pathologist for various COG (Children’s Oncology Group) brain tumor study committees/ clinical trials (including high grade gliomas, medulloblastomas, and ependymomas) and is a member of the National Medulloblastoma Reference Laboratory at NCH. He is also a Central Review Pathologist for the NEXT Consortium/ Head Start 4 International Clinical Trial for Medulloblastomas and other CNS Embryonal Tumors, which will soon include similar trials for Choroid Plexus Carcinomas and Ependymomas.

He currently serves on the following committees: Institute for Genomic Medicine Epilepsy Genomics; CNS Cancer Predisposition Organizing Committee; Institute for Genomic Medicine Brain Tumor Genomics; Surgical Pathology QA Committee; OSU COM (MD) Admissions Committee and Medical Careers Pathway Post-Baccalaureate Program (MEDPATH) and on the Society for Pediatric Pathology’s Research and Awards Committee; Children’s Oncology Group ACNS1422 Medulloblastoma Study Committee; Children’s Oncology Group ACNS0831 Ependymoma Study Committee; and Children’s Oncology Group Medulloblastoma Reference Laboratory.

His particular clinical interests are in the diagnosis of pediatric brain tumors, pediatric neuromuscular diseases, and pediatric hematopathologic conditions. His research interests are in the diagnostic and prognostic features of pediatric brain tumors. He is a co- investigator on various federal and local grants to study pediatric brain tumors and muscle diseases. Particular educational interests are in the teaching of various neuropathology topics to neurosurgery, general surgery, pathology, neurology, and pediatrics residents and medical student trainees.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Locations

Main Campus of Nationwide Children’s Hospital

Locations

Main Campus of Nationwide Children’s Hospital

Locations

Main Campus of Nationwide Children’s Hospital

• Main Campus of Nationwide Children’s Hospital

Academic and Clinical Areas

Pathology Fellowship

Faculty

Pathology and Laboratory Medicine

Anatomic Pathology Team

Anatomic Pathology

Director, Neuropathology

Neuro-Oncology

Physician Team

Clinical Pathology

Pathologist, Clinical Pathology

Clinical Neurophysiology Fellowship

Faculty

Primary Department

Pathology & Laboratory Medicine

Primary Section

Anatomic Pathology

Academic and Clinical Areas

Pathology Fellowship

Faculty

Pathology and Laboratory Medicine

Anatomic Pathology Team

Anatomic Pathology

Director, Neuropathology

Neuro-Oncology

Physician Team

Clinical Pathology

Pathologist, Clinical Pathology

Clinical Neurophysiology Fellowship

Faculty

Primary Department

Pathology & Laboratory Medicine

Primary Section

Anatomic Pathology

Academic and Clinical Areas

Pathology Fellowship

Faculty

Pathology and Laboratory Medicine

Anatomic Pathology Team

Anatomic Pathology

Director, Neuropathology

Neuro-Oncology

Physician Team

Clinical Pathology

Pathologist, Clinical Pathology

Clinical Neurophysiology Fellowship

Faculty

Primary Department

Pathology & Laboratory Medicine

Primary Section

Anatomic Pathology

Pathology Fellowship

Faculty

Pathology and Laboratory Medicine

Anatomic Pathology Team

Anatomic Pathology

Director, Neuropathology

Neuro-Oncology

Physician Team

Clinical Pathology

Pathologist, Clinical Pathology

Clinical Neurophysiology Fellowship

Faculty

Primary Department

Pathology & Laboratory Medicine

Primary Section

Anatomic Pathology

• Pathology Fellowship
• Faculty
• Pathology and Laboratory Medicine
• Anatomic Pathology Team
• Anatomic Pathology
• Director, Neuropathology
• Neuro-Oncology
• Physician Team
• Clinical Pathology
• Pathologist, Clinical Pathology
• Clinical Neurophysiology Fellowship
• Faculty
• Primary Department
• Pathology & Laboratory Medicine
• Primary Section
• Anatomic Pathology

Awards, Honors & Organizations

Member, Alpha Omega Alpha (National) Honor Medical Society, 1990 Listed, Guide to America’s Top Pathologists, Consumers Research Council of America Sheard- Sanford Award, American Society for Clinical Pathology

Awards, Honors & Organizations

Member, Alpha Omega Alpha (National) Honor Medical Society, 1990 Listed, Guide to America’s Top Pathologists, Consumers Research Council of America Sheard- Sanford Award, American Society for Clinical Pathology

Awards, Honors & Organizations

Member, Alpha Omega Alpha (National) Honor Medical Society, 1990 Listed, Guide to America’s Top Pathologists, Consumers Research Council of America Sheard- Sanford Award, American Society for Clinical Pathology

Member, Alpha Omega Alpha (National) Honor Medical Society, 1990 Listed, Guide to America’s Top Pathologists, Consumers Research Council of America Sheard- Sanford Award, American Society for Clinical Pathology

• Member, Alpha Omega Alpha (National) Honor Medical Society, 1990
• Listed, Guide to America’s Top Pathologists, Consumers Research Council of America
• Sheard- Sanford Award, American Society for Clinical Pathology

Research

Publications

                  Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.

                


                  Garcia MR, Feng Y, Vasudevaraja V, Galbraith K, Serrano J, Thomas C, Radmanesh A, Hidalgo ET, Harter DH, Allen JC, Gardner SL, Osorio DS, William CM, Zagzag D, Boué DR, Snuderl M. Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas. J Neuropathol Exp Neurol. 2022 Aug 23;  

                


                  Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;  

                


                  De Faria FW, Schieffer KM, Pierson CR, Boue DR, LaHaye S, Miller KE, Amayiri N, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly B, White P, Magrini V, Wilson RK, Mardis ER, Cottrell CE, Rusin J, Finlay JL, Osorio DS. Infantile metastatic ependymoma with a novel molecular profile and favorable outcome to intensive chemotherapy without irradiation: Case-based review. Genes Chromosomes Cancer. 2022 Jun 18;  

                


                  Guney E, Lucas CG, Qi Z, Yu J, Zhang R, Ohgami RS, Rubenstein JL, Boué DR, Schafernak KT, Wertheim GB, Dahiya S, Giulino-Roth L, Attarbaschi A, Barth MJ, Kothari S, Abla O, Cohen AL, Mendez JS, Bollen AW, Perry A, Tihan T, Pekmezci M, Solomon DA, Wen KW. A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome. Blood Adv. 2022 Feb 14;  

                


                  Miller KE, Wheeler G, LaHaye S, Schieffer KM, Cearlock S, Venkata LPR, Bravo AO, Grischow OE, Kelly BJ, White P, Pierson CR, Boué DR, Koo SC, Klawinski D, Ranalli MA, Shaikhouni A, Salloum R, Shatara M, Leonard JR, Wilson RK, Cottrell CE, Mardis ER, Koboldt DC. Molecular Heterogeneity in Pediatric Malignant Rhabdoid Tumors in Patients With Multi-Organ Involvement. Front Oncol. 2022; 12: 932337.

                


                  Ronsley R, Boué DR, Venkata LPR, Scott S, Shaikhouni A, Jones J, Schieffer KM, Cottrell CE, Mardis ER, Olshefski R, Salloum R, Miller KE. An unusual case of atypical teratoid/rhabdoid tumor, initially diagnosed as atypical pituitary adenoma in a 13-year-old male patient. Neurooncol Adv. 2022 Jan-Dec; 4: vdac121.

                


                  Shatara M, Schieffer KM, Klawinski D, Thomas DL, Pierson CR, Sribnick EA, Jones J, Rodriguez DP, Deeg C, Hamelberg E, LaHaye S, Miller KE, Fitch J, Kelly B, Leraas K, Pfau R, White P, Magrini V, Wilson RK, Mardis ER, Abdelbaki MS, Finlay JL, Boué DR, Cottrell CE, Ghasemi DR, Pajtler KW, Osorio DS. Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas. Acta Neuropathol Commun. 2021 Dec 11; 9: 192.

                


                  LaHaye S, Fitch JR, Voytovich KJ, Herman AC, Kelly BJ, Lammi GE, Arbesfeld JA, Wijeratne S, Franklin SJ, Schieffer KM, Bir N, McGrath SD, Miller AR, Wetzel A, Miller KE, Bedrosian TA, Leraas K, Varga EA, Lee K, Gupta A, Setty B, Boué DR, Leonard JR, Finlay JL, Abdelbaki MS, Osorio DS, Koo SC, Koboldt DC, Wagner AH, Eisfeld AK, Mrózek K, Magrini V, Cottrell CE, Mardis ER, Wilson RK, White P. Discovery of clinically relevant fusions in pediatric cancer. BMC Genomics. 2021 Dec 4; 22: 872.

                


                  Harris MK, Shatara M, Funk Z, Stanek J, Boué DR, Jones J, Finlay JL, Abdelbaki MS. Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature. Childs Nerv Syst. 2021 May 4;  

                


                  Schieffer KM, Feldman AZ, Kautto EA, McGrath S, Miller AR, Hernandez-Gonzalez ME, LaHaye S, Miller KE, Koboldt DC, Brennan P, Kelly B, Wetzel A, Agarwal V, Shatara M, Conley S, Rodriguez DP, Abu-Arja R, Shaikhkhalil A, Snuderl M, Orr BA, Finlay JL, Osorio DS, Drapeau AI, Leonard JR, Pierson CR, White P, Magrini V, Mardis ER, Wilson RK, Cottrell CE, Boué DR. Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma. Acta Neuropathol Commun. 2021 Apr 7; 9: 61.

                


                  Schieffer KM, Agarwal V, LaHaye S, Miller KE, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly BJ, Crist E, Rusin J, Finlay JL, Osorio DS, Sribnick EA, Leonard JR, Feldman A, Orr BA, Serrano J, Vasudevaraja V, Snuderl M, White P, Magrini V, Wilson RK, Mardis ER, Boué DR, Cottrell CE. YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas. Am J Surg Pathol. 2021 Mar 1; 45: 329-340.

                


                  Yankelevich M, Finlay JL, Gorsi H, Kupsky W, Boue DR, Koschmann CJ, Kumar-Sinha C, Mody R. Molecular insights into malignant progression of atypical choroid plexus papilloma. Cold Spring Harb Mol Case Stud. 2021 Feb; 7: 

                


                  Lazow MA, Hoffman L, Schafer A, Osorio DS, Boué DR, Rush S, Wright E, Lane A, DeWire-Schottmiller MD, Smolarek T, Sipple J, Taggert H, Reuss J, Salloum R, Hummel TR, de Blank P, Pillay-Smiley N, Sutton ME, Asher A, Stevenson CB, Drissi R, Finlay JL, Fouladi M, Fuller C. Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas. Acta Neuropathol Commun. 2020 Nov 5; 8: 182.

                


                  Toland A, McNulty SN, Pekmezci M, Evenson M, Huntoon K, Pierson CR, Boue DR, Perry A, Dahiya S. Pediatric meningioma: A clinicopathologic and molecular study with potential grading implications. Brain Pathol. 2020 Jul 27;  

                


                  Tang K, Kurland D, Vasudevaraja V, Serrano J, Delorenzo M, Radmanesh A, Thomas C, Spino M, Gardner S, Allen JC, Nicolaides T, Osorio DS, Finlay JL, Boué DR, Snuderl M. Exploring DNA Methylation for Prognosis and Analyzing the Tumor Microenvironment in Pleomorphic Xanthoastrocytoma. J Neuropathol Exp Neurol. 2020 Jun 28;  

                


                  Liu H, Guinipero TL, Schieffer KM, Carter C, Colace S, Leonard JR, Orr BA, Kahwash SB, Brennan PJ, Fitch JR, Kelly B, Magrini VJ, White P, Wilson RK, Mardis ER, Cottrell CE, Boué DR. De novo primary central nervous system pure erythroid leukemia/sarcoma with t(1;16)(p31;q24) NFIA/CBFA2T3 translocation. Haematologica. 2020 Apr; 105: e194-e197.

                


                  Kanchan RK, Perumal N, Atri P, Chirravuri Venkata R, Thapa I, Klinkebiel DL, Donson AM, Perry D, Punsoni M, Talmon GA, Coulter DW, Boue' DR, Snuderl M, Nasser MW, Batra SK, Vibhakar R, Mahapatra S. MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3). Brain Pathol. 2020 Mar 7;  

                


                  Nobre L, Zapotocky M, Ramaswamy V, Ryall S, Bennett J, Alderete D, Balaguer Guill J, Baroni L, Bartels U, Bavle A, Bornhorst M, Boue DR, Canete A, Chintagumpala M, Coven SL, Cruz O, Dahiya S, Dirks P, Dunkel IJ, Eisenstat D, Faure Conter C, Finch E, Finlay JL, Frappaz D, Garre ML, Gauvain K, Bechensteen AG, Hansford JR, Harting I, Hauser P, Hazrati LN, Huang A, Injac SG, Iurilli V, Karajannis M, Kaur G, Kyncl M, Krskova L, Laperriere N, Larouche V, Lassaletta A, Leary S, Lin F, Mascelli S, McKeown T, Milde T, Morales La Madrid A, Morana G, Morse H, Mushtaq N, Osorio DS, Packer R, Pavelka Z, Quiroga-Cantero E, Rutka J, Sabel M, Salgado D, Solano P, Sterba J, Su J, Sumerauer D, Taylor MD, Toledano H, Tsang DS, Valente Fernandes M, van Landeghem F, van Tilburg CM, Wilson B, Witt O, Zamecnik J, Bouffet E, Hawkins C, Tabori U. Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition. JCO Precis Oncol. 2020; 4: 

                


                  Richardson TE, Tang K, Vasudevaraja V, Serrano J, William CM, Mirchia K, Pierson CR, Leonard JR, AbdelBaki MS, Schieffer KM, Cottrell CE, Tovar-Spinoza Z, Comito MA, Boué DR, Jour G, Snuderl M. GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors. J Neuropathol Exp Neurol. 2019 Dec 1; 78: 1089-1099.

                


                  Waldrop M, Amornvit J, Pierson CR, Boue DR, Sahenk Z. A Novel De Novo Heterozygous SCN4a Mutation Causing Congenital Myopathy, Myotonia and Multiple Congenital Anomalies. J Neuromuscul Dis. 2019 Oct 8;  

                


                  Guerreiro Stucklin AS, Ryall S, Fukuoka K, Zapotocky M, Lassaletta A, Li C, Bridge T, Kim B, Arnoldo A, Kowalski PE, Zhong Y, Johnson M, Li C, Ramani AK, Siddaway R, Nobre LF, de Antonellis P, Dunham C, Cheng S, Boué DR, Finlay JL, Coven SL, de Prada I, Perez-Somarriba M, Faria CC, Grotzer MA, Rushing E, Sumerauer D, Zamecnik J, Krskova L, Garcia Ariza M, Cruz O, Morales La Madrid A, Solano P, Terashima K, Nakano Y, Ichimura K, Nagane M, Sakamoto H, Gil-da-Costa MJ, Silva R, Johnston DL, Michaud J, Wilson B, van Landeghem FKH, Oviedo A, McNeely PD, Crooks B, Fried I, Zhukova N, Hansford JR, Nageswararao A, Garzia L, Shago M, Brudno M, Irwin MS, Bartels U, Ramaswamy V, Bouffet E, Taylor MD, Tabori U, Hawkins C. Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nat Commun. 2019 Sep 25; 10: 4343.

                


                  Chiang JCH, Harreld JH, Tanaka R, Li X, Wen J, Zhang C, Boué DR, Rauch TM, Boyd JT, Chen J, Corbo JC, Bouldin TW, Elton SW, Liu LL, Schofield D, Lee SC, Bouffard JP, Georgescu MM, Dossani RH, Aguiar MA, Sances RA, Saad AG, Boop FA, Qaddoumi I, Ellison DW. Septal Dysembryoplastic Neuroepithelial Tumor: A Comprehensive Clinical, Imaging, Histopathologic and Molecular Analysis. Neuro Oncol. 2019 Feb 6;  

                


                  Abu Arja MH, Stalling M, Governale LS, Pierson CR, Rusin JA, Palmer JD, Finlay JL, Olshefski R, Boué DR. Germinoma Involving the Retina: An Unusual Presentation of Recurrent Intracranial Mixed Germ Cell Tumor. World Neurosurg. 2019 Jan 7;  

                


                  AbdelBaki MS, Boué DR, Finlay JL, Kieran MW. Desmoplastic nodular medulloblastoma in young children: a management dilemma. Neuro Oncol. 2018 Jul 5; 20: 1026-1033.

                


                  Waldrop MA, Gumienny F, Boue D, de Los Reyes E, Shell R, Weiss RB, Flanigan KM. Low-level expression of EPG5 leads to an attenuated Vici syndrome phenotype. Am J Med Genet A. 2018 May; 176: 1207-1211.

                


                  Miller KE, Kelly B, Fitch J, Ross N, Avenarius MR, Varga E, Koboldt DC, Boué DR, Magrini V, Coven SL, Finlay JL, Cottrell CE, White P, Gastier-Foster JM, Wilson RK, Leonard J, Mardis ER. Genome sequencing identifies somatic BRAF duplication c.1794_1796dupTAC;p.Thr599dup in pediatric patient with low-grade ganglioglioma. Cold Spring Harb Mol Case Stud. 2018 Apr; 4: 

                


                  Abu Arja MH, Conley SE, Salceda V, Al-Sufiani F, Boué DR, Finlay JL. Brentuximab-vedotin maintenance following chemotherapy without irradiation for primary intracranial embryonal carcinoma in down syndrome. Childs Nerv Syst. 2018 Apr; 34: 777-780.

                


                  Salloum R, McConechy MK, Mikael LG, Fuller C, Drissi R, DeWire M, Nikbakht H, De Jay N, Yang X, Boue D, Chow LML, Finlay JL, Gayden T, Karamchandani J, Hummel TR, Olshefski R, Osorio DS, Stevenson C, Kleinman CL, Majewski J, Fouladi M, Jabado N. Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. Acta Neuropathol Commun. 2017 Oct 30; 5: 78.

                


                  Chin Tan G, Stalling M, Boue D, Pyle-Eilola A, Kahwash SB. That's Not Supposed to Be There: An Unusual Finding on Urinalysis. Clin Chem. 2017 Oct; 63: 1660-1661.

                


                  Waldrop MA, Boue DR, Sites E, Flanigan KM, Shell R. Clinicopathologic Conference: A Newborn With Hypotonia, Cleft Palate, Micrognathia, and Bilateral Club Feet. Pediatr Neurol. 2017 Sep; 74: 11-14.

                


                  Huntoon K, Pluto CP, Ruess L, Boué DR, Pierson CR, Rusin JA, Leonard J. Sporadic pediatric meningiomas: a neuroradiological and neuropathological study of 15 cases. J Neurosurg Pediatr. 2017 Aug; 20: 141-148.

View More Publications

Research

Publications

                  Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.

                


                  Garcia MR, Feng Y, Vasudevaraja V, Galbraith K, Serrano J, Thomas C, Radmanesh A, Hidalgo ET, Harter DH, Allen JC, Gardner SL, Osorio DS, William CM, Zagzag D, Boué DR, Snuderl M. Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas. J Neuropathol Exp Neurol. 2022 Aug 23;  

                


                  Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;  

                


                  De Faria FW, Schieffer KM, Pierson CR, Boue DR, LaHaye S, Miller KE, Amayiri N, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly B, White P, Magrini V, Wilson RK, Mardis ER, Cottrell CE, Rusin J, Finlay JL, Osorio DS. Infantile metastatic ependymoma with a novel molecular profile and favorable outcome to intensive chemotherapy without irradiation: Case-based review. Genes Chromosomes Cancer. 2022 Jun 18;  

                


                  Guney E, Lucas CG, Qi Z, Yu J, Zhang R, Ohgami RS, Rubenstein JL, Boué DR, Schafernak KT, Wertheim GB, Dahiya S, Giulino-Roth L, Attarbaschi A, Barth MJ, Kothari S, Abla O, Cohen AL, Mendez JS, Bollen AW, Perry A, Tihan T, Pekmezci M, Solomon DA, Wen KW. A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome. Blood Adv. 2022 Feb 14;  

                


                  Miller KE, Wheeler G, LaHaye S, Schieffer KM, Cearlock S, Venkata LPR, Bravo AO, Grischow OE, Kelly BJ, White P, Pierson CR, Boué DR, Koo SC, Klawinski D, Ranalli MA, Shaikhouni A, Salloum R, Shatara M, Leonard JR, Wilson RK, Cottrell CE, Mardis ER, Koboldt DC. Molecular Heterogeneity in Pediatric Malignant Rhabdoid Tumors in Patients With Multi-Organ Involvement. Front Oncol. 2022; 12: 932337.

                


                  Ronsley R, Boué DR, Venkata LPR, Scott S, Shaikhouni A, Jones J, Schieffer KM, Cottrell CE, Mardis ER, Olshefski R, Salloum R, Miller KE. An unusual case of atypical teratoid/rhabdoid tumor, initially diagnosed as atypical pituitary adenoma in a 13-year-old male patient. Neurooncol Adv. 2022 Jan-Dec; 4: vdac121.

                


                  Shatara M, Schieffer KM, Klawinski D, Thomas DL, Pierson CR, Sribnick EA, Jones J, Rodriguez DP, Deeg C, Hamelberg E, LaHaye S, Miller KE, Fitch J, Kelly B, Leraas K, Pfau R, White P, Magrini V, Wilson RK, Mardis ER, Abdelbaki MS, Finlay JL, Boué DR, Cottrell CE, Ghasemi DR, Pajtler KW, Osorio DS. Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas. Acta Neuropathol Commun. 2021 Dec 11; 9: 192.

                


                  LaHaye S, Fitch JR, Voytovich KJ, Herman AC, Kelly BJ, Lammi GE, Arbesfeld JA, Wijeratne S, Franklin SJ, Schieffer KM, Bir N, McGrath SD, Miller AR, Wetzel A, Miller KE, Bedrosian TA, Leraas K, Varga EA, Lee K, Gupta A, Setty B, Boué DR, Leonard JR, Finlay JL, Abdelbaki MS, Osorio DS, Koo SC, Koboldt DC, Wagner AH, Eisfeld AK, Mrózek K, Magrini V, Cottrell CE, Mardis ER, Wilson RK, White P. Discovery of clinically relevant fusions in pediatric cancer. BMC Genomics. 2021 Dec 4; 22: 872.

                


                  Harris MK, Shatara M, Funk Z, Stanek J, Boué DR, Jones J, Finlay JL, Abdelbaki MS. Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature. Childs Nerv Syst. 2021 May 4;  

                


                  Schieffer KM, Feldman AZ, Kautto EA, McGrath S, Miller AR, Hernandez-Gonzalez ME, LaHaye S, Miller KE, Koboldt DC, Brennan P, Kelly B, Wetzel A, Agarwal V, Shatara M, Conley S, Rodriguez DP, Abu-Arja R, Shaikhkhalil A, Snuderl M, Orr BA, Finlay JL, Osorio DS, Drapeau AI, Leonard JR, Pierson CR, White P, Magrini V, Mardis ER, Wilson RK, Cottrell CE, Boué DR. Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma. Acta Neuropathol Commun. 2021 Apr 7; 9: 61.

                


                  Schieffer KM, Agarwal V, LaHaye S, Miller KE, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly BJ, Crist E, Rusin J, Finlay JL, Osorio DS, Sribnick EA, Leonard JR, Feldman A, Orr BA, Serrano J, Vasudevaraja V, Snuderl M, White P, Magrini V, Wilson RK, Mardis ER, Boué DR, Cottrell CE. YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas. Am J Surg Pathol. 2021 Mar 1; 45: 329-340.

                


                  Yankelevich M, Finlay JL, Gorsi H, Kupsky W, Boue DR, Koschmann CJ, Kumar-Sinha C, Mody R. Molecular insights into malignant progression of atypical choroid plexus papilloma. Cold Spring Harb Mol Case Stud. 2021 Feb; 7: 

                


                  Lazow MA, Hoffman L, Schafer A, Osorio DS, Boué DR, Rush S, Wright E, Lane A, DeWire-Schottmiller MD, Smolarek T, Sipple J, Taggert H, Reuss J, Salloum R, Hummel TR, de Blank P, Pillay-Smiley N, Sutton ME, Asher A, Stevenson CB, Drissi R, Finlay JL, Fouladi M, Fuller C. Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas. Acta Neuropathol Commun. 2020 Nov 5; 8: 182.

                


                  Toland A, McNulty SN, Pekmezci M, Evenson M, Huntoon K, Pierson CR, Boue DR, Perry A, Dahiya S. Pediatric meningioma: A clinicopathologic and molecular study with potential grading implications. Brain Pathol. 2020 Jul 27;  

                


                  Tang K, Kurland D, Vasudevaraja V, Serrano J, Delorenzo M, Radmanesh A, Thomas C, Spino M, Gardner S, Allen JC, Nicolaides T, Osorio DS, Finlay JL, Boué DR, Snuderl M. Exploring DNA Methylation for Prognosis and Analyzing the Tumor Microenvironment in Pleomorphic Xanthoastrocytoma. J Neuropathol Exp Neurol. 2020 Jun 28;  

                


                  Liu H, Guinipero TL, Schieffer KM, Carter C, Colace S, Leonard JR, Orr BA, Kahwash SB, Brennan PJ, Fitch JR, Kelly B, Magrini VJ, White P, Wilson RK, Mardis ER, Cottrell CE, Boué DR. De novo primary central nervous system pure erythroid leukemia/sarcoma with t(1;16)(p31;q24) NFIA/CBFA2T3 translocation. Haematologica. 2020 Apr; 105: e194-e197.

                


                  Kanchan RK, Perumal N, Atri P, Chirravuri Venkata R, Thapa I, Klinkebiel DL, Donson AM, Perry D, Punsoni M, Talmon GA, Coulter DW, Boue' DR, Snuderl M, Nasser MW, Batra SK, Vibhakar R, Mahapatra S. MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3). Brain Pathol. 2020 Mar 7;  

                


                  Nobre L, Zapotocky M, Ramaswamy V, Ryall S, Bennett J, Alderete D, Balaguer Guill J, Baroni L, Bartels U, Bavle A, Bornhorst M, Boue DR, Canete A, Chintagumpala M, Coven SL, Cruz O, Dahiya S, Dirks P, Dunkel IJ, Eisenstat D, Faure Conter C, Finch E, Finlay JL, Frappaz D, Garre ML, Gauvain K, Bechensteen AG, Hansford JR, Harting I, Hauser P, Hazrati LN, Huang A, Injac SG, Iurilli V, Karajannis M, Kaur G, Kyncl M, Krskova L, Laperriere N, Larouche V, Lassaletta A, Leary S, Lin F, Mascelli S, McKeown T, Milde T, Morales La Madrid A, Morana G, Morse H, Mushtaq N, Osorio DS, Packer R, Pavelka Z, Quiroga-Cantero E, Rutka J, Sabel M, Salgado D, Solano P, Sterba J, Su J, Sumerauer D, Taylor MD, Toledano H, Tsang DS, Valente Fernandes M, van Landeghem F, van Tilburg CM, Wilson B, Witt O, Zamecnik J, Bouffet E, Hawkins C, Tabori U. Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition. JCO Precis Oncol. 2020; 4: 

                


                  Richardson TE, Tang K, Vasudevaraja V, Serrano J, William CM, Mirchia K, Pierson CR, Leonard JR, AbdelBaki MS, Schieffer KM, Cottrell CE, Tovar-Spinoza Z, Comito MA, Boué DR, Jour G, Snuderl M. GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors. J Neuropathol Exp Neurol. 2019 Dec 1; 78: 1089-1099.

                


                  Waldrop M, Amornvit J, Pierson CR, Boue DR, Sahenk Z. A Novel De Novo Heterozygous SCN4a Mutation Causing Congenital Myopathy, Myotonia and Multiple Congenital Anomalies. J Neuromuscul Dis. 2019 Oct 8;  

                


                  Guerreiro Stucklin AS, Ryall S, Fukuoka K, Zapotocky M, Lassaletta A, Li C, Bridge T, Kim B, Arnoldo A, Kowalski PE, Zhong Y, Johnson M, Li C, Ramani AK, Siddaway R, Nobre LF, de Antonellis P, Dunham C, Cheng S, Boué DR, Finlay JL, Coven SL, de Prada I, Perez-Somarriba M, Faria CC, Grotzer MA, Rushing E, Sumerauer D, Zamecnik J, Krskova L, Garcia Ariza M, Cruz O, Morales La Madrid A, Solano P, Terashima K, Nakano Y, Ichimura K, Nagane M, Sakamoto H, Gil-da-Costa MJ, Silva R, Johnston DL, Michaud J, Wilson B, van Landeghem FKH, Oviedo A, McNeely PD, Crooks B, Fried I, Zhukova N, Hansford JR, Nageswararao A, Garzia L, Shago M, Brudno M, Irwin MS, Bartels U, Ramaswamy V, Bouffet E, Taylor MD, Tabori U, Hawkins C. Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nat Commun. 2019 Sep 25; 10: 4343.

                


                  Chiang JCH, Harreld JH, Tanaka R, Li X, Wen J, Zhang C, Boué DR, Rauch TM, Boyd JT, Chen J, Corbo JC, Bouldin TW, Elton SW, Liu LL, Schofield D, Lee SC, Bouffard JP, Georgescu MM, Dossani RH, Aguiar MA, Sances RA, Saad AG, Boop FA, Qaddoumi I, Ellison DW. Septal Dysembryoplastic Neuroepithelial Tumor: A Comprehensive Clinical, Imaging, Histopathologic and Molecular Analysis. Neuro Oncol. 2019 Feb 6;  

                


                  Abu Arja MH, Stalling M, Governale LS, Pierson CR, Rusin JA, Palmer JD, Finlay JL, Olshefski R, Boué DR. Germinoma Involving the Retina: An Unusual Presentation of Recurrent Intracranial Mixed Germ Cell Tumor. World Neurosurg. 2019 Jan 7;  

                


                  AbdelBaki MS, Boué DR, Finlay JL, Kieran MW. Desmoplastic nodular medulloblastoma in young children: a management dilemma. Neuro Oncol. 2018 Jul 5; 20: 1026-1033.

                


                  Waldrop MA, Gumienny F, Boue D, de Los Reyes E, Shell R, Weiss RB, Flanigan KM. Low-level expression of EPG5 leads to an attenuated Vici syndrome phenotype. Am J Med Genet A. 2018 May; 176: 1207-1211.

                


                  Miller KE, Kelly B, Fitch J, Ross N, Avenarius MR, Varga E, Koboldt DC, Boué DR, Magrini V, Coven SL, Finlay JL, Cottrell CE, White P, Gastier-Foster JM, Wilson RK, Leonard J, Mardis ER. Genome sequencing identifies somatic BRAF duplication c.1794_1796dupTAC;p.Thr599dup in pediatric patient with low-grade ganglioglioma. Cold Spring Harb Mol Case Stud. 2018 Apr; 4: 

                


                  Abu Arja MH, Conley SE, Salceda V, Al-Sufiani F, Boué DR, Finlay JL. Brentuximab-vedotin maintenance following chemotherapy without irradiation for primary intracranial embryonal carcinoma in down syndrome. Childs Nerv Syst. 2018 Apr; 34: 777-780.

                


                  Salloum R, McConechy MK, Mikael LG, Fuller C, Drissi R, DeWire M, Nikbakht H, De Jay N, Yang X, Boue D, Chow LML, Finlay JL, Gayden T, Karamchandani J, Hummel TR, Olshefski R, Osorio DS, Stevenson C, Kleinman CL, Majewski J, Fouladi M, Jabado N. Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. Acta Neuropathol Commun. 2017 Oct 30; 5: 78.

                


                  Chin Tan G, Stalling M, Boue D, Pyle-Eilola A, Kahwash SB. That's Not Supposed to Be There: An Unusual Finding on Urinalysis. Clin Chem. 2017 Oct; 63: 1660-1661.

                


                  Waldrop MA, Boue DR, Sites E, Flanigan KM, Shell R. Clinicopathologic Conference: A Newborn With Hypotonia, Cleft Palate, Micrognathia, and Bilateral Club Feet. Pediatr Neurol. 2017 Sep; 74: 11-14.

                


                  Huntoon K, Pluto CP, Ruess L, Boué DR, Pierson CR, Rusin JA, Leonard J. Sporadic pediatric meningiomas: a neuroradiological and neuropathological study of 15 cases. J Neurosurg Pediatr. 2017 Aug; 20: 141-148.

View More Publications

Research

Publications

                  Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.

                


                  Garcia MR, Feng Y, Vasudevaraja V, Galbraith K, Serrano J, Thomas C, Radmanesh A, Hidalgo ET, Harter DH, Allen JC, Gardner SL, Osorio DS, William CM, Zagzag D, Boué DR, Snuderl M. Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas. J Neuropathol Exp Neurol. 2022 Aug 23;  

                


                  Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;  

                


                  De Faria FW, Schieffer KM, Pierson CR, Boue DR, LaHaye S, Miller KE, Amayiri N, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly B, White P, Magrini V, Wilson RK, Mardis ER, Cottrell CE, Rusin J, Finlay JL, Osorio DS. Infantile metastatic ependymoma with a novel molecular profile and favorable outcome to intensive chemotherapy without irradiation: Case-based review. Genes Chromosomes Cancer. 2022 Jun 18;  

                


                  Guney E, Lucas CG, Qi Z, Yu J, Zhang R, Ohgami RS, Rubenstein JL, Boué DR, Schafernak KT, Wertheim GB, Dahiya S, Giulino-Roth L, Attarbaschi A, Barth MJ, Kothari S, Abla O, Cohen AL, Mendez JS, Bollen AW, Perry A, Tihan T, Pekmezci M, Solomon DA, Wen KW. A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome. Blood Adv. 2022 Feb 14;  

                


                  Miller KE, Wheeler G, LaHaye S, Schieffer KM, Cearlock S, Venkata LPR, Bravo AO, Grischow OE, Kelly BJ, White P, Pierson CR, Boué DR, Koo SC, Klawinski D, Ranalli MA, Shaikhouni A, Salloum R, Shatara M, Leonard JR, Wilson RK, Cottrell CE, Mardis ER, Koboldt DC. Molecular Heterogeneity in Pediatric Malignant Rhabdoid Tumors in Patients With Multi-Organ Involvement. Front Oncol. 2022; 12: 932337.

                


                  Ronsley R, Boué DR, Venkata LPR, Scott S, Shaikhouni A, Jones J, Schieffer KM, Cottrell CE, Mardis ER, Olshefski R, Salloum R, Miller KE. An unusual case of atypical teratoid/rhabdoid tumor, initially diagnosed as atypical pituitary adenoma in a 13-year-old male patient. Neurooncol Adv. 2022 Jan-Dec; 4: vdac121.

                


                  Shatara M, Schieffer KM, Klawinski D, Thomas DL, Pierson CR, Sribnick EA, Jones J, Rodriguez DP, Deeg C, Hamelberg E, LaHaye S, Miller KE, Fitch J, Kelly B, Leraas K, Pfau R, White P, Magrini V, Wilson RK, Mardis ER, Abdelbaki MS, Finlay JL, Boué DR, Cottrell CE, Ghasemi DR, Pajtler KW, Osorio DS. Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas. Acta Neuropathol Commun. 2021 Dec 11; 9: 192.

                


                  LaHaye S, Fitch JR, Voytovich KJ, Herman AC, Kelly BJ, Lammi GE, Arbesfeld JA, Wijeratne S, Franklin SJ, Schieffer KM, Bir N, McGrath SD, Miller AR, Wetzel A, Miller KE, Bedrosian TA, Leraas K, Varga EA, Lee K, Gupta A, Setty B, Boué DR, Leonard JR, Finlay JL, Abdelbaki MS, Osorio DS, Koo SC, Koboldt DC, Wagner AH, Eisfeld AK, Mrózek K, Magrini V, Cottrell CE, Mardis ER, Wilson RK, White P. Discovery of clinically relevant fusions in pediatric cancer. BMC Genomics. 2021 Dec 4; 22: 872.

                


                  Harris MK, Shatara M, Funk Z, Stanek J, Boué DR, Jones J, Finlay JL, Abdelbaki MS. Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature. Childs Nerv Syst. 2021 May 4;  

                


                  Schieffer KM, Feldman AZ, Kautto EA, McGrath S, Miller AR, Hernandez-Gonzalez ME, LaHaye S, Miller KE, Koboldt DC, Brennan P, Kelly B, Wetzel A, Agarwal V, Shatara M, Conley S, Rodriguez DP, Abu-Arja R, Shaikhkhalil A, Snuderl M, Orr BA, Finlay JL, Osorio DS, Drapeau AI, Leonard JR, Pierson CR, White P, Magrini V, Mardis ER, Wilson RK, Cottrell CE, Boué DR. Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma. Acta Neuropathol Commun. 2021 Apr 7; 9: 61.

                


                  Schieffer KM, Agarwal V, LaHaye S, Miller KE, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly BJ, Crist E, Rusin J, Finlay JL, Osorio DS, Sribnick EA, Leonard JR, Feldman A, Orr BA, Serrano J, Vasudevaraja V, Snuderl M, White P, Magrini V, Wilson RK, Mardis ER, Boué DR, Cottrell CE. YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas. Am J Surg Pathol. 2021 Mar 1; 45: 329-340.

                


                  Yankelevich M, Finlay JL, Gorsi H, Kupsky W, Boue DR, Koschmann CJ, Kumar-Sinha C, Mody R. Molecular insights into malignant progression of atypical choroid plexus papilloma. Cold Spring Harb Mol Case Stud. 2021 Feb; 7: 

                


                  Lazow MA, Hoffman L, Schafer A, Osorio DS, Boué DR, Rush S, Wright E, Lane A, DeWire-Schottmiller MD, Smolarek T, Sipple J, Taggert H, Reuss J, Salloum R, Hummel TR, de Blank P, Pillay-Smiley N, Sutton ME, Asher A, Stevenson CB, Drissi R, Finlay JL, Fouladi M, Fuller C. Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas. Acta Neuropathol Commun. 2020 Nov 5; 8: 182.

                


                  Toland A, McNulty SN, Pekmezci M, Evenson M, Huntoon K, Pierson CR, Boue DR, Perry A, Dahiya S. Pediatric meningioma: A clinicopathologic and molecular study with potential grading implications. Brain Pathol. 2020 Jul 27;  

                


                  Tang K, Kurland D, Vasudevaraja V, Serrano J, Delorenzo M, Radmanesh A, Thomas C, Spino M, Gardner S, Allen JC, Nicolaides T, Osorio DS, Finlay JL, Boué DR, Snuderl M. Exploring DNA Methylation for Prognosis and Analyzing the Tumor Microenvironment in Pleomorphic Xanthoastrocytoma. J Neuropathol Exp Neurol. 2020 Jun 28;  

                


                  Liu H, Guinipero TL, Schieffer KM, Carter C, Colace S, Leonard JR, Orr BA, Kahwash SB, Brennan PJ, Fitch JR, Kelly B, Magrini VJ, White P, Wilson RK, Mardis ER, Cottrell CE, Boué DR. De novo primary central nervous system pure erythroid leukemia/sarcoma with t(1;16)(p31;q24) NFIA/CBFA2T3 translocation. Haematologica. 2020 Apr; 105: e194-e197.

                


                  Kanchan RK, Perumal N, Atri P, Chirravuri Venkata R, Thapa I, Klinkebiel DL, Donson AM, Perry D, Punsoni M, Talmon GA, Coulter DW, Boue' DR, Snuderl M, Nasser MW, Batra SK, Vibhakar R, Mahapatra S. MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3). Brain Pathol. 2020 Mar 7;  

                


                  Nobre L, Zapotocky M, Ramaswamy V, Ryall S, Bennett J, Alderete D, Balaguer Guill J, Baroni L, Bartels U, Bavle A, Bornhorst M, Boue DR, Canete A, Chintagumpala M, Coven SL, Cruz O, Dahiya S, Dirks P, Dunkel IJ, Eisenstat D, Faure Conter C, Finch E, Finlay JL, Frappaz D, Garre ML, Gauvain K, Bechensteen AG, Hansford JR, Harting I, Hauser P, Hazrati LN, Huang A, Injac SG, Iurilli V, Karajannis M, Kaur G, Kyncl M, Krskova L, Laperriere N, Larouche V, Lassaletta A, Leary S, Lin F, Mascelli S, McKeown T, Milde T, Morales La Madrid A, Morana G, Morse H, Mushtaq N, Osorio DS, Packer R, Pavelka Z, Quiroga-Cantero E, Rutka J, Sabel M, Salgado D, Solano P, Sterba J, Su J, Sumerauer D, Taylor MD, Toledano H, Tsang DS, Valente Fernandes M, van Landeghem F, van Tilburg CM, Wilson B, Witt O, Zamecnik J, Bouffet E, Hawkins C, Tabori U. Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition. JCO Precis Oncol. 2020; 4: 

                


                  Richardson TE, Tang K, Vasudevaraja V, Serrano J, William CM, Mirchia K, Pierson CR, Leonard JR, AbdelBaki MS, Schieffer KM, Cottrell CE, Tovar-Spinoza Z, Comito MA, Boué DR, Jour G, Snuderl M. GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors. J Neuropathol Exp Neurol. 2019 Dec 1; 78: 1089-1099.

                


                  Waldrop M, Amornvit J, Pierson CR, Boue DR, Sahenk Z. A Novel De Novo Heterozygous SCN4a Mutation Causing Congenital Myopathy, Myotonia and Multiple Congenital Anomalies. J Neuromuscul Dis. 2019 Oct 8;  

                


                  Guerreiro Stucklin AS, Ryall S, Fukuoka K, Zapotocky M, Lassaletta A, Li C, Bridge T, Kim B, Arnoldo A, Kowalski PE, Zhong Y, Johnson M, Li C, Ramani AK, Siddaway R, Nobre LF, de Antonellis P, Dunham C, Cheng S, Boué DR, Finlay JL, Coven SL, de Prada I, Perez-Somarriba M, Faria CC, Grotzer MA, Rushing E, Sumerauer D, Zamecnik J, Krskova L, Garcia Ariza M, Cruz O, Morales La Madrid A, Solano P, Terashima K, Nakano Y, Ichimura K, Nagane M, Sakamoto H, Gil-da-Costa MJ, Silva R, Johnston DL, Michaud J, Wilson B, van Landeghem FKH, Oviedo A, McNeely PD, Crooks B, Fried I, Zhukova N, Hansford JR, Nageswararao A, Garzia L, Shago M, Brudno M, Irwin MS, Bartels U, Ramaswamy V, Bouffet E, Taylor MD, Tabori U, Hawkins C. Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nat Commun. 2019 Sep 25; 10: 4343.

                


                  Chiang JCH, Harreld JH, Tanaka R, Li X, Wen J, Zhang C, Boué DR, Rauch TM, Boyd JT, Chen J, Corbo JC, Bouldin TW, Elton SW, Liu LL, Schofield D, Lee SC, Bouffard JP, Georgescu MM, Dossani RH, Aguiar MA, Sances RA, Saad AG, Boop FA, Qaddoumi I, Ellison DW. Septal Dysembryoplastic Neuroepithelial Tumor: A Comprehensive Clinical, Imaging, Histopathologic and Molecular Analysis. Neuro Oncol. 2019 Feb 6;  

                


                  Abu Arja MH, Stalling M, Governale LS, Pierson CR, Rusin JA, Palmer JD, Finlay JL, Olshefski R, Boué DR. Germinoma Involving the Retina: An Unusual Presentation of Recurrent Intracranial Mixed Germ Cell Tumor. World Neurosurg. 2019 Jan 7;  

                


                  AbdelBaki MS, Boué DR, Finlay JL, Kieran MW. Desmoplastic nodular medulloblastoma in young children: a management dilemma. Neuro Oncol. 2018 Jul 5; 20: 1026-1033.

                


                  Waldrop MA, Gumienny F, Boue D, de Los Reyes E, Shell R, Weiss RB, Flanigan KM. Low-level expression of EPG5 leads to an attenuated Vici syndrome phenotype. Am J Med Genet A. 2018 May; 176: 1207-1211.

                


                  Miller KE, Kelly B, Fitch J, Ross N, Avenarius MR, Varga E, Koboldt DC, Boué DR, Magrini V, Coven SL, Finlay JL, Cottrell CE, White P, Gastier-Foster JM, Wilson RK, Leonard J, Mardis ER. Genome sequencing identifies somatic BRAF duplication c.1794_1796dupTAC;p.Thr599dup in pediatric patient with low-grade ganglioglioma. Cold Spring Harb Mol Case Stud. 2018 Apr; 4: 

                


                  Abu Arja MH, Conley SE, Salceda V, Al-Sufiani F, Boué DR, Finlay JL. Brentuximab-vedotin maintenance following chemotherapy without irradiation for primary intracranial embryonal carcinoma in down syndrome. Childs Nerv Syst. 2018 Apr; 34: 777-780.

                


                  Salloum R, McConechy MK, Mikael LG, Fuller C, Drissi R, DeWire M, Nikbakht H, De Jay N, Yang X, Boue D, Chow LML, Finlay JL, Gayden T, Karamchandani J, Hummel TR, Olshefski R, Osorio DS, Stevenson C, Kleinman CL, Majewski J, Fouladi M, Jabado N. Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. Acta Neuropathol Commun. 2017 Oct 30; 5: 78.

                


                  Chin Tan G, Stalling M, Boue D, Pyle-Eilola A, Kahwash SB. That's Not Supposed to Be There: An Unusual Finding on Urinalysis. Clin Chem. 2017 Oct; 63: 1660-1661.

                


                  Waldrop MA, Boue DR, Sites E, Flanigan KM, Shell R. Clinicopathologic Conference: A Newborn With Hypotonia, Cleft Palate, Micrognathia, and Bilateral Club Feet. Pediatr Neurol. 2017 Sep; 74: 11-14.

                


                  Huntoon K, Pluto CP, Ruess L, Boué DR, Pierson CR, Rusin JA, Leonard J. Sporadic pediatric meningiomas: a neuroradiological and neuropathological study of 15 cases. J Neurosurg Pediatr. 2017 Aug; 20: 141-148.

View More Publications

Publications

                  Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.

                


                  Garcia MR, Feng Y, Vasudevaraja V, Galbraith K, Serrano J, Thomas C, Radmanesh A, Hidalgo ET, Harter DH, Allen JC, Gardner SL, Osorio DS, William CM, Zagzag D, Boué DR, Snuderl M. Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas. J Neuropathol Exp Neurol. 2022 Aug 23;  

                


                  Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;  

                


                  De Faria FW, Schieffer KM, Pierson CR, Boue DR, LaHaye S, Miller KE, Amayiri N, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly B, White P, Magrini V, Wilson RK, Mardis ER, Cottrell CE, Rusin J, Finlay JL, Osorio DS. Infantile metastatic ependymoma with a novel molecular profile and favorable outcome to intensive chemotherapy without irradiation: Case-based review. Genes Chromosomes Cancer. 2022 Jun 18;  

                


                  Guney E, Lucas CG, Qi Z, Yu J, Zhang R, Ohgami RS, Rubenstein JL, Boué DR, Schafernak KT, Wertheim GB, Dahiya S, Giulino-Roth L, Attarbaschi A, Barth MJ, Kothari S, Abla O, Cohen AL, Mendez JS, Bollen AW, Perry A, Tihan T, Pekmezci M, Solomon DA, Wen KW. A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome. Blood Adv. 2022 Feb 14;  

                


                  Miller KE, Wheeler G, LaHaye S, Schieffer KM, Cearlock S, Venkata LPR, Bravo AO, Grischow OE, Kelly BJ, White P, Pierson CR, Boué DR, Koo SC, Klawinski D, Ranalli MA, Shaikhouni A, Salloum R, Shatara M, Leonard JR, Wilson RK, Cottrell CE, Mardis ER, Koboldt DC. Molecular Heterogeneity in Pediatric Malignant Rhabdoid Tumors in Patients With Multi-Organ Involvement. Front Oncol. 2022; 12: 932337.

                


                  Ronsley R, Boué DR, Venkata LPR, Scott S, Shaikhouni A, Jones J, Schieffer KM, Cottrell CE, Mardis ER, Olshefski R, Salloum R, Miller KE. An unusual case of atypical teratoid/rhabdoid tumor, initially diagnosed as atypical pituitary adenoma in a 13-year-old male patient. Neurooncol Adv. 2022 Jan-Dec; 4: vdac121.

                


                  Shatara M, Schieffer KM, Klawinski D, Thomas DL, Pierson CR, Sribnick EA, Jones J, Rodriguez DP, Deeg C, Hamelberg E, LaHaye S, Miller KE, Fitch J, Kelly B, Leraas K, Pfau R, White P, Magrini V, Wilson RK, Mardis ER, Abdelbaki MS, Finlay JL, Boué DR, Cottrell CE, Ghasemi DR, Pajtler KW, Osorio DS. Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas. Acta Neuropathol Commun. 2021 Dec 11; 9: 192.

                


                  LaHaye S, Fitch JR, Voytovich KJ, Herman AC, Kelly BJ, Lammi GE, Arbesfeld JA, Wijeratne S, Franklin SJ, Schieffer KM, Bir N, McGrath SD, Miller AR, Wetzel A, Miller KE, Bedrosian TA, Leraas K, Varga EA, Lee K, Gupta A, Setty B, Boué DR, Leonard JR, Finlay JL, Abdelbaki MS, Osorio DS, Koo SC, Koboldt DC, Wagner AH, Eisfeld AK, Mrózek K, Magrini V, Cottrell CE, Mardis ER, Wilson RK, White P. Discovery of clinically relevant fusions in pediatric cancer. BMC Genomics. 2021 Dec 4; 22: 872.

                


                  Harris MK, Shatara M, Funk Z, Stanek J, Boué DR, Jones J, Finlay JL, Abdelbaki MS. Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature. Childs Nerv Syst. 2021 May 4;  

                


                  Schieffer KM, Feldman AZ, Kautto EA, McGrath S, Miller AR, Hernandez-Gonzalez ME, LaHaye S, Miller KE, Koboldt DC, Brennan P, Kelly B, Wetzel A, Agarwal V, Shatara M, Conley S, Rodriguez DP, Abu-Arja R, Shaikhkhalil A, Snuderl M, Orr BA, Finlay JL, Osorio DS, Drapeau AI, Leonard JR, Pierson CR, White P, Magrini V, Mardis ER, Wilson RK, Cottrell CE, Boué DR. Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma. Acta Neuropathol Commun. 2021 Apr 7; 9: 61.

                


                  Schieffer KM, Agarwal V, LaHaye S, Miller KE, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly BJ, Crist E, Rusin J, Finlay JL, Osorio DS, Sribnick EA, Leonard JR, Feldman A, Orr BA, Serrano J, Vasudevaraja V, Snuderl M, White P, Magrini V, Wilson RK, Mardis ER, Boué DR, Cottrell CE. YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas. Am J Surg Pathol. 2021 Mar 1; 45: 329-340.

                


                  Yankelevich M, Finlay JL, Gorsi H, Kupsky W, Boue DR, Koschmann CJ, Kumar-Sinha C, Mody R. Molecular insights into malignant progression of atypical choroid plexus papilloma. Cold Spring Harb Mol Case Stud. 2021 Feb; 7: 

                


                  Lazow MA, Hoffman L, Schafer A, Osorio DS, Boué DR, Rush S, Wright E, Lane A, DeWire-Schottmiller MD, Smolarek T, Sipple J, Taggert H, Reuss J, Salloum R, Hummel TR, de Blank P, Pillay-Smiley N, Sutton ME, Asher A, Stevenson CB, Drissi R, Finlay JL, Fouladi M, Fuller C. Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas. Acta Neuropathol Commun. 2020 Nov 5; 8: 182.

                


                  Toland A, McNulty SN, Pekmezci M, Evenson M, Huntoon K, Pierson CR, Boue DR, Perry A, Dahiya S. Pediatric meningioma: A clinicopathologic and molecular study with potential grading implications. Brain Pathol. 2020 Jul 27;  

                


                  Tang K, Kurland D, Vasudevaraja V, Serrano J, Delorenzo M, Radmanesh A, Thomas C, Spino M, Gardner S, Allen JC, Nicolaides T, Osorio DS, Finlay JL, Boué DR, Snuderl M. Exploring DNA Methylation for Prognosis and Analyzing the Tumor Microenvironment in Pleomorphic Xanthoastrocytoma. J Neuropathol Exp Neurol. 2020 Jun 28;  

                


                  Liu H, Guinipero TL, Schieffer KM, Carter C, Colace S, Leonard JR, Orr BA, Kahwash SB, Brennan PJ, Fitch JR, Kelly B, Magrini VJ, White P, Wilson RK, Mardis ER, Cottrell CE, Boué DR. De novo primary central nervous system pure erythroid leukemia/sarcoma with t(1;16)(p31;q24) NFIA/CBFA2T3 translocation. Haematologica. 2020 Apr; 105: e194-e197.

                


                  Kanchan RK, Perumal N, Atri P, Chirravuri Venkata R, Thapa I, Klinkebiel DL, Donson AM, Perry D, Punsoni M, Talmon GA, Coulter DW, Boue' DR, Snuderl M, Nasser MW, Batra SK, Vibhakar R, Mahapatra S. MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3). Brain Pathol. 2020 Mar 7;  

                


                  Nobre L, Zapotocky M, Ramaswamy V, Ryall S, Bennett J, Alderete D, Balaguer Guill J, Baroni L, Bartels U, Bavle A, Bornhorst M, Boue DR, Canete A, Chintagumpala M, Coven SL, Cruz O, Dahiya S, Dirks P, Dunkel IJ, Eisenstat D, Faure Conter C, Finch E, Finlay JL, Frappaz D, Garre ML, Gauvain K, Bechensteen AG, Hansford JR, Harting I, Hauser P, Hazrati LN, Huang A, Injac SG, Iurilli V, Karajannis M, Kaur G, Kyncl M, Krskova L, Laperriere N, Larouche V, Lassaletta A, Leary S, Lin F, Mascelli S, McKeown T, Milde T, Morales La Madrid A, Morana G, Morse H, Mushtaq N, Osorio DS, Packer R, Pavelka Z, Quiroga-Cantero E, Rutka J, Sabel M, Salgado D, Solano P, Sterba J, Su J, Sumerauer D, Taylor MD, Toledano H, Tsang DS, Valente Fernandes M, van Landeghem F, van Tilburg CM, Wilson B, Witt O, Zamecnik J, Bouffet E, Hawkins C, Tabori U. Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition. JCO Precis Oncol. 2020; 4: 

                


                  Richardson TE, Tang K, Vasudevaraja V, Serrano J, William CM, Mirchia K, Pierson CR, Leonard JR, AbdelBaki MS, Schieffer KM, Cottrell CE, Tovar-Spinoza Z, Comito MA, Boué DR, Jour G, Snuderl M. GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors. J Neuropathol Exp Neurol. 2019 Dec 1; 78: 1089-1099.

                


                  Waldrop M, Amornvit J, Pierson CR, Boue DR, Sahenk Z. A Novel De Novo Heterozygous SCN4a Mutation Causing Congenital Myopathy, Myotonia and Multiple Congenital Anomalies. J Neuromuscul Dis. 2019 Oct 8;  

                


                  Guerreiro Stucklin AS, Ryall S, Fukuoka K, Zapotocky M, Lassaletta A, Li C, Bridge T, Kim B, Arnoldo A, Kowalski PE, Zhong Y, Johnson M, Li C, Ramani AK, Siddaway R, Nobre LF, de Antonellis P, Dunham C, Cheng S, Boué DR, Finlay JL, Coven SL, de Prada I, Perez-Somarriba M, Faria CC, Grotzer MA, Rushing E, Sumerauer D, Zamecnik J, Krskova L, Garcia Ariza M, Cruz O, Morales La Madrid A, Solano P, Terashima K, Nakano Y, Ichimura K, Nagane M, Sakamoto H, Gil-da-Costa MJ, Silva R, Johnston DL, Michaud J, Wilson B, van Landeghem FKH, Oviedo A, McNeely PD, Crooks B, Fried I, Zhukova N, Hansford JR, Nageswararao A, Garzia L, Shago M, Brudno M, Irwin MS, Bartels U, Ramaswamy V, Bouffet E, Taylor MD, Tabori U, Hawkins C. Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nat Commun. 2019 Sep 25; 10: 4343.

                


                  Chiang JCH, Harreld JH, Tanaka R, Li X, Wen J, Zhang C, Boué DR, Rauch TM, Boyd JT, Chen J, Corbo JC, Bouldin TW, Elton SW, Liu LL, Schofield D, Lee SC, Bouffard JP, Georgescu MM, Dossani RH, Aguiar MA, Sances RA, Saad AG, Boop FA, Qaddoumi I, Ellison DW. Septal Dysembryoplastic Neuroepithelial Tumor: A Comprehensive Clinical, Imaging, Histopathologic and Molecular Analysis. Neuro Oncol. 2019 Feb 6;  

                


                  Abu Arja MH, Stalling M, Governale LS, Pierson CR, Rusin JA, Palmer JD, Finlay JL, Olshefski R, Boué DR. Germinoma Involving the Retina: An Unusual Presentation of Recurrent Intracranial Mixed Germ Cell Tumor. World Neurosurg. 2019 Jan 7;  

                


                  AbdelBaki MS, Boué DR, Finlay JL, Kieran MW. Desmoplastic nodular medulloblastoma in young children: a management dilemma. Neuro Oncol. 2018 Jul 5; 20: 1026-1033.

                


                  Waldrop MA, Gumienny F, Boue D, de Los Reyes E, Shell R, Weiss RB, Flanigan KM. Low-level expression of EPG5 leads to an attenuated Vici syndrome phenotype. Am J Med Genet A. 2018 May; 176: 1207-1211.

                


                  Miller KE, Kelly B, Fitch J, Ross N, Avenarius MR, Varga E, Koboldt DC, Boué DR, Magrini V, Coven SL, Finlay JL, Cottrell CE, White P, Gastier-Foster JM, Wilson RK, Leonard J, Mardis ER. Genome sequencing identifies somatic BRAF duplication c.1794_1796dupTAC;p.Thr599dup in pediatric patient with low-grade ganglioglioma. Cold Spring Harb Mol Case Stud. 2018 Apr; 4: 

                


                  Abu Arja MH, Conley SE, Salceda V, Al-Sufiani F, Boué DR, Finlay JL. Brentuximab-vedotin maintenance following chemotherapy without irradiation for primary intracranial embryonal carcinoma in down syndrome. Childs Nerv Syst. 2018 Apr; 34: 777-780.

                


                  Salloum R, McConechy MK, Mikael LG, Fuller C, Drissi R, DeWire M, Nikbakht H, De Jay N, Yang X, Boue D, Chow LML, Finlay JL, Gayden T, Karamchandani J, Hummel TR, Olshefski R, Osorio DS, Stevenson C, Kleinman CL, Majewski J, Fouladi M, Jabado N. Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. Acta Neuropathol Commun. 2017 Oct 30; 5: 78.

                


                  Chin Tan G, Stalling M, Boue D, Pyle-Eilola A, Kahwash SB. That's Not Supposed to Be There: An Unusual Finding on Urinalysis. Clin Chem. 2017 Oct; 63: 1660-1661.

                


                  Waldrop MA, Boue DR, Sites E, Flanigan KM, Shell R. Clinicopathologic Conference: A Newborn With Hypotonia, Cleft Palate, Micrognathia, and Bilateral Club Feet. Pediatr Neurol. 2017 Sep; 74: 11-14.

                


                  Huntoon K, Pluto CP, Ruess L, Boué DR, Pierson CR, Rusin JA, Leonard J. Sporadic pediatric meningiomas: a neuroradiological and neuropathological study of 15 cases. J Neurosurg Pediatr. 2017 Aug; 20: 141-148.

View More Publications

                  Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.

                


                  Garcia MR, Feng Y, Vasudevaraja V, Galbraith K, Serrano J, Thomas C, Radmanesh A, Hidalgo ET, Harter DH, Allen JC, Gardner SL, Osorio DS, William CM, Zagzag D, Boué DR, Snuderl M. Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas. J Neuropathol Exp Neurol. 2022 Aug 23;  

                


                  Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;  

                


                  De Faria FW, Schieffer KM, Pierson CR, Boue DR, LaHaye S, Miller KE, Amayiri N, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly B, White P, Magrini V, Wilson RK, Mardis ER, Cottrell CE, Rusin J, Finlay JL, Osorio DS. Infantile metastatic ependymoma with a novel molecular profile and favorable outcome to intensive chemotherapy without irradiation: Case-based review. Genes Chromosomes Cancer. 2022 Jun 18;  

                


                  Guney E, Lucas CG, Qi Z, Yu J, Zhang R, Ohgami RS, Rubenstein JL, Boué DR, Schafernak KT, Wertheim GB, Dahiya S, Giulino-Roth L, Attarbaschi A, Barth MJ, Kothari S, Abla O, Cohen AL, Mendez JS, Bollen AW, Perry A, Tihan T, Pekmezci M, Solomon DA, Wen KW. A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome. Blood Adv. 2022 Feb 14;  

                


                  Miller KE, Wheeler G, LaHaye S, Schieffer KM, Cearlock S, Venkata LPR, Bravo AO, Grischow OE, Kelly BJ, White P, Pierson CR, Boué DR, Koo SC, Klawinski D, Ranalli MA, Shaikhouni A, Salloum R, Shatara M, Leonard JR, Wilson RK, Cottrell CE, Mardis ER, Koboldt DC. Molecular Heterogeneity in Pediatric Malignant Rhabdoid Tumors in Patients With Multi-Organ Involvement. Front Oncol. 2022; 12: 932337.

                


                  Ronsley R, Boué DR, Venkata LPR, Scott S, Shaikhouni A, Jones J, Schieffer KM, Cottrell CE, Mardis ER, Olshefski R, Salloum R, Miller KE. An unusual case of atypical teratoid/rhabdoid tumor, initially diagnosed as atypical pituitary adenoma in a 13-year-old male patient. Neurooncol Adv. 2022 Jan-Dec; 4: vdac121.

                


                  Shatara M, Schieffer KM, Klawinski D, Thomas DL, Pierson CR, Sribnick EA, Jones J, Rodriguez DP, Deeg C, Hamelberg E, LaHaye S, Miller KE, Fitch J, Kelly B, Leraas K, Pfau R, White P, Magrini V, Wilson RK, Mardis ER, Abdelbaki MS, Finlay JL, Boué DR, Cottrell CE, Ghasemi DR, Pajtler KW, Osorio DS. Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas. Acta Neuropathol Commun. 2021 Dec 11; 9: 192.

                


                  LaHaye S, Fitch JR, Voytovich KJ, Herman AC, Kelly BJ, Lammi GE, Arbesfeld JA, Wijeratne S, Franklin SJ, Schieffer KM, Bir N, McGrath SD, Miller AR, Wetzel A, Miller KE, Bedrosian TA, Leraas K, Varga EA, Lee K, Gupta A, Setty B, Boué DR, Leonard JR, Finlay JL, Abdelbaki MS, Osorio DS, Koo SC, Koboldt DC, Wagner AH, Eisfeld AK, Mrózek K, Magrini V, Cottrell CE, Mardis ER, Wilson RK, White P. Discovery of clinically relevant fusions in pediatric cancer. BMC Genomics. 2021 Dec 4; 22: 872.

                


                  Harris MK, Shatara M, Funk Z, Stanek J, Boué DR, Jones J, Finlay JL, Abdelbaki MS. Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature. Childs Nerv Syst. 2021 May 4;  

                


                  Schieffer KM, Feldman AZ, Kautto EA, McGrath S, Miller AR, Hernandez-Gonzalez ME, LaHaye S, Miller KE, Koboldt DC, Brennan P, Kelly B, Wetzel A, Agarwal V, Shatara M, Conley S, Rodriguez DP, Abu-Arja R, Shaikhkhalil A, Snuderl M, Orr BA, Finlay JL, Osorio DS, Drapeau AI, Leonard JR, Pierson CR, White P, Magrini V, Mardis ER, Wilson RK, Cottrell CE, Boué DR. Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma. Acta Neuropathol Commun. 2021 Apr 7; 9: 61.

                


                  Schieffer KM, Agarwal V, LaHaye S, Miller KE, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly BJ, Crist E, Rusin J, Finlay JL, Osorio DS, Sribnick EA, Leonard JR, Feldman A, Orr BA, Serrano J, Vasudevaraja V, Snuderl M, White P, Magrini V, Wilson RK, Mardis ER, Boué DR, Cottrell CE. YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas. Am J Surg Pathol. 2021 Mar 1; 45: 329-340.

                


                  Yankelevich M, Finlay JL, Gorsi H, Kupsky W, Boue DR, Koschmann CJ, Kumar-Sinha C, Mody R. Molecular insights into malignant progression of atypical choroid plexus papilloma. Cold Spring Harb Mol Case Stud. 2021 Feb; 7: 

                


                  Lazow MA, Hoffman L, Schafer A, Osorio DS, Boué DR, Rush S, Wright E, Lane A, DeWire-Schottmiller MD, Smolarek T, Sipple J, Taggert H, Reuss J, Salloum R, Hummel TR, de Blank P, Pillay-Smiley N, Sutton ME, Asher A, Stevenson CB, Drissi R, Finlay JL, Fouladi M, Fuller C. Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas. Acta Neuropathol Commun. 2020 Nov 5; 8: 182.

                


                  Toland A, McNulty SN, Pekmezci M, Evenson M, Huntoon K, Pierson CR, Boue DR, Perry A, Dahiya S. Pediatric meningioma: A clinicopathologic and molecular study with potential grading implications. Brain Pathol. 2020 Jul 27;  

                


                  Tang K, Kurland D, Vasudevaraja V, Serrano J, Delorenzo M, Radmanesh A, Thomas C, Spino M, Gardner S, Allen JC, Nicolaides T, Osorio DS, Finlay JL, Boué DR, Snuderl M. Exploring DNA Methylation for Prognosis and Analyzing the Tumor Microenvironment in Pleomorphic Xanthoastrocytoma. J Neuropathol Exp Neurol. 2020 Jun 28;  

                


                  Liu H, Guinipero TL, Schieffer KM, Carter C, Colace S, Leonard JR, Orr BA, Kahwash SB, Brennan PJ, Fitch JR, Kelly B, Magrini VJ, White P, Wilson RK, Mardis ER, Cottrell CE, Boué DR. De novo primary central nervous system pure erythroid leukemia/sarcoma with t(1;16)(p31;q24) NFIA/CBFA2T3 translocation. Haematologica. 2020 Apr; 105: e194-e197.

                


                  Kanchan RK, Perumal N, Atri P, Chirravuri Venkata R, Thapa I, Klinkebiel DL, Donson AM, Perry D, Punsoni M, Talmon GA, Coulter DW, Boue' DR, Snuderl M, Nasser MW, Batra SK, Vibhakar R, Mahapatra S. MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3). Brain Pathol. 2020 Mar 7;  

                


                  Nobre L, Zapotocky M, Ramaswamy V, Ryall S, Bennett J, Alderete D, Balaguer Guill J, Baroni L, Bartels U, Bavle A, Bornhorst M, Boue DR, Canete A, Chintagumpala M, Coven SL, Cruz O, Dahiya S, Dirks P, Dunkel IJ, Eisenstat D, Faure Conter C, Finch E, Finlay JL, Frappaz D, Garre ML, Gauvain K, Bechensteen AG, Hansford JR, Harting I, Hauser P, Hazrati LN, Huang A, Injac SG, Iurilli V, Karajannis M, Kaur G, Kyncl M, Krskova L, Laperriere N, Larouche V, Lassaletta A, Leary S, Lin F, Mascelli S, McKeown T, Milde T, Morales La Madrid A, Morana G, Morse H, Mushtaq N, Osorio DS, Packer R, Pavelka Z, Quiroga-Cantero E, Rutka J, Sabel M, Salgado D, Solano P, Sterba J, Su J, Sumerauer D, Taylor MD, Toledano H, Tsang DS, Valente Fernandes M, van Landeghem F, van Tilburg CM, Wilson B, Witt O, Zamecnik J, Bouffet E, Hawkins C, Tabori U. Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition. JCO Precis Oncol. 2020; 4: 

                


                  Richardson TE, Tang K, Vasudevaraja V, Serrano J, William CM, Mirchia K, Pierson CR, Leonard JR, AbdelBaki MS, Schieffer KM, Cottrell CE, Tovar-Spinoza Z, Comito MA, Boué DR, Jour G, Snuderl M. GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors. J Neuropathol Exp Neurol. 2019 Dec 1; 78: 1089-1099.

                


                  Waldrop M, Amornvit J, Pierson CR, Boue DR, Sahenk Z. A Novel De Novo Heterozygous SCN4a Mutation Causing Congenital Myopathy, Myotonia and Multiple Congenital Anomalies. J Neuromuscul Dis. 2019 Oct 8;  

                


                  Guerreiro Stucklin AS, Ryall S, Fukuoka K, Zapotocky M, Lassaletta A, Li C, Bridge T, Kim B, Arnoldo A, Kowalski PE, Zhong Y, Johnson M, Li C, Ramani AK, Siddaway R, Nobre LF, de Antonellis P, Dunham C, Cheng S, Boué DR, Finlay JL, Coven SL, de Prada I, Perez-Somarriba M, Faria CC, Grotzer MA, Rushing E, Sumerauer D, Zamecnik J, Krskova L, Garcia Ariza M, Cruz O, Morales La Madrid A, Solano P, Terashima K, Nakano Y, Ichimura K, Nagane M, Sakamoto H, Gil-da-Costa MJ, Silva R, Johnston DL, Michaud J, Wilson B, van Landeghem FKH, Oviedo A, McNeely PD, Crooks B, Fried I, Zhukova N, Hansford JR, Nageswararao A, Garzia L, Shago M, Brudno M, Irwin MS, Bartels U, Ramaswamy V, Bouffet E, Taylor MD, Tabori U, Hawkins C. Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nat Commun. 2019 Sep 25; 10: 4343.

                


                  Chiang JCH, Harreld JH, Tanaka R, Li X, Wen J, Zhang C, Boué DR, Rauch TM, Boyd JT, Chen J, Corbo JC, Bouldin TW, Elton SW, Liu LL, Schofield D, Lee SC, Bouffard JP, Georgescu MM, Dossani RH, Aguiar MA, Sances RA, Saad AG, Boop FA, Qaddoumi I, Ellison DW. Septal Dysembryoplastic Neuroepithelial Tumor: A Comprehensive Clinical, Imaging, Histopathologic and Molecular Analysis. Neuro Oncol. 2019 Feb 6;  

                


                  Abu Arja MH, Stalling M, Governale LS, Pierson CR, Rusin JA, Palmer JD, Finlay JL, Olshefski R, Boué DR. Germinoma Involving the Retina: An Unusual Presentation of Recurrent Intracranial Mixed Germ Cell Tumor. World Neurosurg. 2019 Jan 7;  

                


                  AbdelBaki MS, Boué DR, Finlay JL, Kieran MW. Desmoplastic nodular medulloblastoma in young children: a management dilemma. Neuro Oncol. 2018 Jul 5; 20: 1026-1033.

                


                  Waldrop MA, Gumienny F, Boue D, de Los Reyes E, Shell R, Weiss RB, Flanigan KM. Low-level expression of EPG5 leads to an attenuated Vici syndrome phenotype. Am J Med Genet A. 2018 May; 176: 1207-1211.

                


                  Miller KE, Kelly B, Fitch J, Ross N, Avenarius MR, Varga E, Koboldt DC, Boué DR, Magrini V, Coven SL, Finlay JL, Cottrell CE, White P, Gastier-Foster JM, Wilson RK, Leonard J, Mardis ER. Genome sequencing identifies somatic BRAF duplication c.1794_1796dupTAC;p.Thr599dup in pediatric patient with low-grade ganglioglioma. Cold Spring Harb Mol Case Stud. 2018 Apr; 4: 

                


                  Abu Arja MH, Conley SE, Salceda V, Al-Sufiani F, Boué DR, Finlay JL. Brentuximab-vedotin maintenance following chemotherapy without irradiation for primary intracranial embryonal carcinoma in down syndrome. Childs Nerv Syst. 2018 Apr; 34: 777-780.

                


                  Salloum R, McConechy MK, Mikael LG, Fuller C, Drissi R, DeWire M, Nikbakht H, De Jay N, Yang X, Boue D, Chow LML, Finlay JL, Gayden T, Karamchandani J, Hummel TR, Olshefski R, Osorio DS, Stevenson C, Kleinman CL, Majewski J, Fouladi M, Jabado N. Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. Acta Neuropathol Commun. 2017 Oct 30; 5: 78.

                


                  Chin Tan G, Stalling M, Boue D, Pyle-Eilola A, Kahwash SB. That's Not Supposed to Be There: An Unusual Finding on Urinalysis. Clin Chem. 2017 Oct; 63: 1660-1661.

                


                  Waldrop MA, Boue DR, Sites E, Flanigan KM, Shell R. Clinicopathologic Conference: A Newborn With Hypotonia, Cleft Palate, Micrognathia, and Bilateral Club Feet. Pediatr Neurol. 2017 Sep; 74: 11-14.

                


                  Huntoon K, Pluto CP, Ruess L, Boué DR, Pierson CR, Rusin JA, Leonard J. Sporadic pediatric meningiomas: a neuroradiological and neuropathological study of 15 cases. J Neurosurg Pediatr. 2017 Aug; 20: 141-148.

View More Publications

• Westfall JJ, Schwind WN, Sran S, Navarro JB, Leonard J, Pindrik JA, Pierson CR, Boué DR, Koboldt DC, Ostendorf AP, Wilson RK, Mardis ER, Miller KE, Bedrosian TA. Molecular and spatial heterogeneity of microglia in Rasmussen encephalitis. Acta Neuropathol Commun. 2022 Nov 21; 10: 168.
• Garcia MR, Feng Y, Vasudevaraja V, Galbraith K, Serrano J, Thomas C, Radmanesh A, Hidalgo ET, Harter DH, Allen JC, Gardner SL, Osorio DS, William CM, Zagzag D, Boué DR, Snuderl M. Clinical, Pathological, and Molecular Characteristics of Diffuse Spinal Cord Gliomas. J Neuropathol Exp Neurol. 2022 Aug 23;
• Bedrosian TA, Miller KE, Grischow OE, Schieffer KM, LaHaye S, Yoon H, Miller AR, Navarro J, Westfall J, Leraas K, Choi S, Williamson R, Fitch J, Kelly BJ, White P, Lee K, McGrath S, Cottrell CE, Magrini V, Leonard J, Pindrik J, Shaikhouni A, Boué DR, Thomas DL, Pierson CR, Wilson RK, Ostendorf AP, Mardis ER, Koboldt DC. Detection of brain somatic variation in epilepsy-associated developmental lesions. Epilepsia. 2022 Jun 10;
• De Faria FW, Schieffer KM, Pierson CR, Boue DR, LaHaye S, Miller KE, Amayiri N, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly B, White P, Magrini V, Wilson RK, Mardis ER, Cottrell CE, Rusin J, Finlay JL, Osorio DS. Infantile metastatic ependymoma with a novel molecular profile and favorable outcome to intensive chemotherapy without irradiation: Case-based review. Genes Chromosomes Cancer. 2022 Jun 18;
• Guney E, Lucas CG, Qi Z, Yu J, Zhang R, Ohgami RS, Rubenstein JL, Boué DR, Schafernak KT, Wertheim GB, Dahiya S, Giulino-Roth L, Attarbaschi A, Barth MJ, Kothari S, Abla O, Cohen AL, Mendez JS, Bollen AW, Perry A, Tihan T, Pekmezci M, Solomon DA, Wen KW. A genetically distinct pediatric subtype of primary CNS large B-cell lymphoma is associated with favorable clinical outcome. Blood Adv. 2022 Feb 14;
• Miller KE, Wheeler G, LaHaye S, Schieffer KM, Cearlock S, Venkata LPR, Bravo AO, Grischow OE, Kelly BJ, White P, Pierson CR, Boué DR, Koo SC, Klawinski D, Ranalli MA, Shaikhouni A, Salloum R, Shatara M, Leonard JR, Wilson RK, Cottrell CE, Mardis ER, Koboldt DC. Molecular Heterogeneity in Pediatric Malignant Rhabdoid Tumors in Patients With Multi-Organ Involvement. Front Oncol. 2022; 12: 932337.
• Ronsley R, Boué DR, Venkata LPR, Scott S, Shaikhouni A, Jones J, Schieffer KM, Cottrell CE, Mardis ER, Olshefski R, Salloum R, Miller KE. An unusual case of atypical teratoid/rhabdoid tumor, initially diagnosed as atypical pituitary adenoma in a 13-year-old male patient. Neurooncol Adv. 2022 Jan-Dec; 4: vdac121.
• Shatara M, Schieffer KM, Klawinski D, Thomas DL, Pierson CR, Sribnick EA, Jones J, Rodriguez DP, Deeg C, Hamelberg E, LaHaye S, Miller KE, Fitch J, Kelly B, Leraas K, Pfau R, White P, Magrini V, Wilson RK, Mardis ER, Abdelbaki MS, Finlay JL, Boué DR, Cottrell CE, Ghasemi DR, Pajtler KW, Osorio DS. Clinically aggressive pediatric spinal ependymoma with novel MYC amplification demonstrates molecular and histopathologic similarity to newly described MYCN-amplified spinal ependymomas. Acta Neuropathol Commun. 2021 Dec 11; 9: 192.
• LaHaye S, Fitch JR, Voytovich KJ, Herman AC, Kelly BJ, Lammi GE, Arbesfeld JA, Wijeratne S, Franklin SJ, Schieffer KM, Bir N, McGrath SD, Miller AR, Wetzel A, Miller KE, Bedrosian TA, Leraas K, Varga EA, Lee K, Gupta A, Setty B, Boué DR, Leonard JR, Finlay JL, Abdelbaki MS, Osorio DS, Koo SC, Koboldt DC, Wagner AH, Eisfeld AK, Mrózek K, Magrini V, Cottrell CE, Mardis ER, Wilson RK, White P. Discovery of clinically relevant fusions in pediatric cancer. BMC Genomics. 2021 Dec 4; 22: 872.
• Harris MK, Shatara M, Funk Z, Stanek J, Boué DR, Jones J, Finlay JL, Abdelbaki MS. Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature. Childs Nerv Syst. 2021 May 4;
• Schieffer KM, Feldman AZ, Kautto EA, McGrath S, Miller AR, Hernandez-Gonzalez ME, LaHaye S, Miller KE, Koboldt DC, Brennan P, Kelly B, Wetzel A, Agarwal V, Shatara M, Conley S, Rodriguez DP, Abu-Arja R, Shaikhkhalil A, Snuderl M, Orr BA, Finlay JL, Osorio DS, Drapeau AI, Leonard JR, Pierson CR, White P, Magrini V, Mardis ER, Wilson RK, Cottrell CE, Boué DR. Molecular classification of a complex structural rearrangement of the RB1 locus in an infant with sporadic, isolated, intracranial, sellar region retinoblastoma. Acta Neuropathol Commun. 2021 Apr 7; 9: 61.
• Schieffer KM, Agarwal V, LaHaye S, Miller KE, Koboldt DC, Lichtenberg T, Leraas K, Brennan P, Kelly BJ, Crist E, Rusin J, Finlay JL, Osorio DS, Sribnick EA, Leonard JR, Feldman A, Orr BA, Serrano J, Vasudevaraja V, Snuderl M, White P, Magrini V, Wilson RK, Mardis ER, Boué DR, Cottrell CE. YAP1-FAM118B Fusion Defines a Rare Subset of Childhood and Young Adulthood Meningiomas. Am J Surg Pathol. 2021 Mar 1; 45: 329-340.
• Yankelevich M, Finlay JL, Gorsi H, Kupsky W, Boue DR, Koschmann CJ, Kumar-Sinha C, Mody R. Molecular insights into malignant progression of atypical choroid plexus papilloma. Cold Spring Harb Mol Case Stud. 2021 Feb; 7:
• Lazow MA, Hoffman L, Schafer A, Osorio DS, Boué DR, Rush S, Wright E, Lane A, DeWire-Schottmiller MD, Smolarek T, Sipple J, Taggert H, Reuss J, Salloum R, Hummel TR, de Blank P, Pillay-Smiley N, Sutton ME, Asher A, Stevenson CB, Drissi R, Finlay JL, Fouladi M, Fuller C. Characterizing temporal genomic heterogeneity in pediatric low-grade gliomas. Acta Neuropathol Commun. 2020 Nov 5; 8: 182.
• Toland A, McNulty SN, Pekmezci M, Evenson M, Huntoon K, Pierson CR, Boue DR, Perry A, Dahiya S. Pediatric meningioma: A clinicopathologic and molecular study with potential grading implications. Brain Pathol. 2020 Jul 27;
• Tang K, Kurland D, Vasudevaraja V, Serrano J, Delorenzo M, Radmanesh A, Thomas C, Spino M, Gardner S, Allen JC, Nicolaides T, Osorio DS, Finlay JL, Boué DR, Snuderl M. Exploring DNA Methylation for Prognosis and Analyzing the Tumor Microenvironment in Pleomorphic Xanthoastrocytoma. J Neuropathol Exp Neurol. 2020 Jun 28;
• Liu H, Guinipero TL, Schieffer KM, Carter C, Colace S, Leonard JR, Orr BA, Kahwash SB, Brennan PJ, Fitch JR, Kelly B, Magrini VJ, White P, Wilson RK, Mardis ER, Cottrell CE, Boué DR. De novo primary central nervous system pure erythroid leukemia/sarcoma with t(1;16)(p31;q24) NFIA/CBFA2T3 translocation. Haematologica. 2020 Apr; 105: e194-e197.
• Kanchan RK, Perumal N, Atri P, Chirravuri Venkata R, Thapa I, Klinkebiel DL, Donson AM, Perry D, Punsoni M, Talmon GA, Coulter DW, Boue’ DR, Snuderl M, Nasser MW, Batra SK, Vibhakar R, Mahapatra S. MiR-1253 exerts tumor-suppressive effects in medulloblastoma via inhibition of CDK6 and CD276 (B7-H3). Brain Pathol. 2020 Mar 7;
• Nobre L, Zapotocky M, Ramaswamy V, Ryall S, Bennett J, Alderete D, Balaguer Guill J, Baroni L, Bartels U, Bavle A, Bornhorst M, Boue DR, Canete A, Chintagumpala M, Coven SL, Cruz O, Dahiya S, Dirks P, Dunkel IJ, Eisenstat D, Faure Conter C, Finch E, Finlay JL, Frappaz D, Garre ML, Gauvain K, Bechensteen AG, Hansford JR, Harting I, Hauser P, Hazrati LN, Huang A, Injac SG, Iurilli V, Karajannis M, Kaur G, Kyncl M, Krskova L, Laperriere N, Larouche V, Lassaletta A, Leary S, Lin F, Mascelli S, McKeown T, Milde T, Morales La Madrid A, Morana G, Morse H, Mushtaq N, Osorio DS, Packer R, Pavelka Z, Quiroga-Cantero E, Rutka J, Sabel M, Salgado D, Solano P, Sterba J, Su J, Sumerauer D, Taylor MD, Toledano H, Tsang DS, Valente Fernandes M, van Landeghem F, van Tilburg CM, Wilson B, Witt O, Zamecnik J, Bouffet E, Hawkins C, Tabori U. Outcomes of BRAF V600E Pediatric Gliomas Treated With Targeted BRAF Inhibition. JCO Precis Oncol. 2020; 4:
• Richardson TE, Tang K, Vasudevaraja V, Serrano J, William CM, Mirchia K, Pierson CR, Leonard JR, AbdelBaki MS, Schieffer KM, Cottrell CE, Tovar-Spinoza Z, Comito MA, Boué DR, Jour G, Snuderl M. GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors. J Neuropathol Exp Neurol. 2019 Dec 1; 78: 1089-1099.
• Waldrop M, Amornvit J, Pierson CR, Boue DR, Sahenk Z. A Novel De Novo Heterozygous SCN4a Mutation Causing Congenital Myopathy, Myotonia and Multiple Congenital Anomalies. J Neuromuscul Dis. 2019 Oct 8;
• Guerreiro Stucklin AS, Ryall S, Fukuoka K, Zapotocky M, Lassaletta A, Li C, Bridge T, Kim B, Arnoldo A, Kowalski PE, Zhong Y, Johnson M, Li C, Ramani AK, Siddaway R, Nobre LF, de Antonellis P, Dunham C, Cheng S, Boué DR, Finlay JL, Coven SL, de Prada I, Perez-Somarriba M, Faria CC, Grotzer MA, Rushing E, Sumerauer D, Zamecnik J, Krskova L, Garcia Ariza M, Cruz O, Morales La Madrid A, Solano P, Terashima K, Nakano Y, Ichimura K, Nagane M, Sakamoto H, Gil-da-Costa MJ, Silva R, Johnston DL, Michaud J, Wilson B, van Landeghem FKH, Oviedo A, McNeely PD, Crooks B, Fried I, Zhukova N, Hansford JR, Nageswararao A, Garzia L, Shago M, Brudno M, Irwin MS, Bartels U, Ramaswamy V, Bouffet E, Taylor MD, Tabori U, Hawkins C. Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas. Nat Commun. 2019 Sep 25; 10: 4343.
• Chiang JCH, Harreld JH, Tanaka R, Li X, Wen J, Zhang C, Boué DR, Rauch TM, Boyd JT, Chen J, Corbo JC, Bouldin TW, Elton SW, Liu LL, Schofield D, Lee SC, Bouffard JP, Georgescu MM, Dossani RH, Aguiar MA, Sances RA, Saad AG, Boop FA, Qaddoumi I, Ellison DW. Septal Dysembryoplastic Neuroepithelial Tumor: A Comprehensive Clinical, Imaging, Histopathologic and Molecular Analysis. Neuro Oncol. 2019 Feb 6;
• Abu Arja MH, Stalling M, Governale LS, Pierson CR, Rusin JA, Palmer JD, Finlay JL, Olshefski R, Boué DR. Germinoma Involving the Retina: An Unusual Presentation of Recurrent Intracranial Mixed Germ Cell Tumor. World Neurosurg. 2019 Jan 7;
• AbdelBaki MS, Boué DR, Finlay JL, Kieran MW. Desmoplastic nodular medulloblastoma in young children: a management dilemma. Neuro Oncol. 2018 Jul 5; 20: 1026-1033.
• Waldrop MA, Gumienny F, Boue D, de Los Reyes E, Shell R, Weiss RB, Flanigan KM. Low-level expression of EPG5 leads to an attenuated Vici syndrome phenotype. Am J Med Genet A. 2018 May; 176: 1207-1211.
• Miller KE, Kelly B, Fitch J, Ross N, Avenarius MR, Varga E, Koboldt DC, Boué DR, Magrini V, Coven SL, Finlay JL, Cottrell CE, White P, Gastier-Foster JM, Wilson RK, Leonard J, Mardis ER. Genome sequencing identifies somatic BRAF duplication c.1794_1796dupTAC;p.Thr599dup in pediatric patient with low-grade ganglioglioma. Cold Spring Harb Mol Case Stud. 2018 Apr; 4:
• Abu Arja MH, Conley SE, Salceda V, Al-Sufiani F, Boué DR, Finlay JL. Brentuximab-vedotin maintenance following chemotherapy without irradiation for primary intracranial embryonal carcinoma in down syndrome. Childs Nerv Syst. 2018 Apr; 34: 777-780.
• Salloum R, McConechy MK, Mikael LG, Fuller C, Drissi R, DeWire M, Nikbakht H, De Jay N, Yang X, Boue D, Chow LML, Finlay JL, Gayden T, Karamchandani J, Hummel TR, Olshefski R, Osorio DS, Stevenson C, Kleinman CL, Majewski J, Fouladi M, Jabado N. Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas. Acta Neuropathol Commun. 2017 Oct 30; 5: 78.
• Chin Tan G, Stalling M, Boue D, Pyle-Eilola A, Kahwash SB. That’s Not Supposed to Be There: An Unusual Finding on Urinalysis. Clin Chem. 2017 Oct; 63: 1660-1661.
• Waldrop MA, Boue DR, Sites E, Flanigan KM, Shell R. Clinicopathologic Conference: A Newborn With Hypotonia, Cleft Palate, Micrognathia, and Bilateral Club Feet. Pediatr Neurol. 2017 Sep; 74: 11-14.
• Huntoon K, Pluto CP, Ruess L, Boué DR, Pierson CR, Rusin JA, Leonard J. Sporadic pediatric meningiomas: a neuroradiological and neuropathological study of 15 cases. J Neurosurg Pediatr. 2017 Aug; 20: 141-148.

Education

Date of Appointment at Nationwide Children’s Hospital: 06/17/1997

Board Certifications

Anatomic Pathology Clinical Pathology Pediatric Pathology

Fellowship

Nationwide Children’s Hospital

Date Completed: 01/05/1997

Fellowship

Nationwide Children’s Hospital

Date Completed: 12/31/1996

Residency

University of California San Diego Medical Center

Date Completed: 06/30/1995

Internship

University of California San Diego Medical Center

Date Completed: 06/30/1992

Medical School

University of Minnesota

Date Completed: 06/08/1991

Education

Date of Appointment at Nationwide Children’s Hospital: 06/17/1997

Board Certifications

Anatomic Pathology Clinical Pathology Pediatric Pathology

Fellowship

Nationwide Children’s Hospital

Date Completed: 01/05/1997

Fellowship

Nationwide Children’s Hospital

Date Completed: 12/31/1996

Residency

University of California San Diego Medical Center

Date Completed: 06/30/1995

Internship

University of California San Diego Medical Center

Date Completed: 06/30/1992

Medical School

University of Minnesota

Date Completed: 06/08/1991

Education

Date of Appointment at Nationwide Children’s Hospital: 06/17/1997

Board Certifications

Anatomic Pathology Clinical Pathology Pediatric Pathology

Fellowship

Nationwide Children’s Hospital

Date Completed: 01/05/1997

Fellowship

Nationwide Children’s Hospital

Date Completed: 12/31/1996

Residency

University of California San Diego Medical Center

Date Completed: 06/30/1995

Internship

University of California San Diego Medical Center

Date Completed: 06/30/1992

Medical School

University of Minnesota

Date Completed: 06/08/1991

Date of Appointment at Nationwide Children’s Hospital: 06/17/1997

Board Certifications

Anatomic Pathology Clinical Pathology Pediatric Pathology

Fellowship

Nationwide Children’s Hospital

Date Completed: 01/05/1997

Fellowship

Nationwide Children’s Hospital

Date Completed: 12/31/1996

Residency

University of California San Diego Medical Center

Date Completed: 06/30/1995

Internship

University of California San Diego Medical Center

Date Completed: 06/30/1992

Medical School

University of Minnesota

Date Completed: 06/08/1991

Date of Appointment at Nationwide Children’s Hospital: 06/17/1997

Board Certifications

Anatomic Pathology Clinical Pathology Pediatric Pathology

Fellowship

Nationwide Children’s Hospital

Date Completed: 01/05/1997

Fellowship

Nationwide Children’s Hospital

Date Completed: 12/31/1996

Residency

University of California San Diego Medical Center

Date Completed: 06/30/1995

Internship

University of California San Diego Medical Center

Date Completed: 06/30/1992

Medical School

University of Minnesota

Date Completed: 06/08/1991

• Anatomic Pathology
• Clinical Pathology
• Pediatric Pathology

Research Funding

National Childhood Cancer Foundation/NIH/ NCI Children’s Oncology Group/Bio-Pathology Center, Other National Childhood Cancer Foundation/COG/NIH/NCI Children’s Oncology Group/Bio-pathology Center/Specimen Banking, Other

Research Funding

National Childhood Cancer Foundation/NIH/ NCI Children’s Oncology Group/Bio-Pathology Center, Other National Childhood Cancer Foundation/COG/NIH/NCI Children’s Oncology Group/Bio-pathology Center/Specimen Banking, Other

Research Funding

National Childhood Cancer Foundation/NIH/ NCI Children’s Oncology Group/Bio-Pathology Center, Other National Childhood Cancer Foundation/COG/NIH/NCI Children’s Oncology Group/Bio-pathology Center/Specimen Banking, Other

National Childhood Cancer Foundation/NIH/ NCI Children’s Oncology Group/Bio-Pathology Center, Other National Childhood Cancer Foundation/COG/NIH/NCI Children’s Oncology Group/Bio-pathology Center/Specimen Banking, Other

Children’s Oncology Group/Bio-Pathology Center, Other

Children’s Oncology Group/Bio-pathology Center/Specimen Banking, Other

Contact Information

Pathology & Laboratory Medicine

Call us at: (614) 722-5450

Fax us at: (614) 722-2899

                    Laboratory Medicine/Clinical Pathology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pathology & Laboratory Medicine

Call us at: (614) 722-5450

Fax us at: (614) 722-2899

                    Laboratory Medicine/Clinical Pathology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pathology & Laboratory Medicine

Call us at: (614) 722-5450

Fax us at: (614) 722-2899

                    Laboratory Medicine/Clinical Pathology700 Children's DrColumbus, OH 43205 (map)

Pathology & Laboratory Medicine

Call us at: (614) 722-5450

Fax us at: (614) 722-2899

                    Laboratory Medicine/Clinical Pathology700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-5450

Fax us at: (614) 722-2899

                    Laboratory Medicine/Clinical Pathology700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-5450

Fax us at: (614) 722-2899

                    Laboratory Medicine/Clinical Pathology700 Children's DrColumbus, OH 43205 (map)

• Call us at:
• (614) 722-5450
• Fax us at:
• (614) 722-2899
• Laboratory Medicine/Clinical Pathology700 Children’s DrColumbus, OH 43205 (map)