Contact Information
Call us at: (614) 722-3900
Fax us at: (614) 722-3903
General Pediatric SurgeryPediatric Surgery700 Children’s DrColumbus, OH 43205 (map)
Learn more about Christopher K. Breuer
Biography
Christopher K. Breuer, MD, is director of the Center for Regenerative Medicine at Nationwide Children’s Hospital, Nationwide Endowed Chair in Surgical Research and director of Tissue Engineering in The Ohio State University Wexner Medical Center’s new Center for Regenerative Medicine and Cell Based Therapies. His clinical and research interests center on bioengineered tissue for use in surgery. Working with Dr. Toshiharu Shinoka, he was the first in the world to tissue engineer blood vessels and implant them in human infants. Dr. Breuer has many honors recognizing his contributions, including the Jacobsen Promising Investigator Award from the American College of Surgeons which is given to the most innovative young surgical investigator in the country.
See Christopher K. Breuer’s Curriculum Vitae (CV)
Patient Care
Locations
Main Campus of Nationwide Children’s Hospital
Academic and Clinical Areas
Pediatric Surgery
Surgeon Team
Pediatric Surgery Residency
Faculty
Surgical Critical Care Fellowship
Faculty
Pediatric Pelvic Reconstruction Fellowship
Faculty
Pediatric Colorectal Research Fellowship
Faculty
Pediatric Colorectal Fellowship
Faculty
Primary Department
General Pediatric Surgery
Awards, Honors & Organizations
Listed, Best Doctors in America
Research
Tissue engineered vascular grafts are used to create an extracardiac total cavopulmonary connection, from the inferior vena cava to the right pulmonary artery, during the Fontan procedure. The right atrium is isolated from venous return. Venous blood is passively delivered to the right pulmonary artery. Publications
Zbinden JC, Mirhaidari GJM, Blum KM, Musgrave AJ, Reinhardt JW, Breuer CK, Barker JC. The lysosomal trafficking regulator is necessary for normal wound healing. Wound Repair Regen. 2022 Jan; 30: 82-99.
Liu L, Dharmadhikari S, Pouliot RA, Li MM, Minneci PM, Tan Z, Shontz K, Johnson J, Reynolds SD, Breuer CK, Weiss DJ, Chiang T. Modulation of Synthetic Tracheal Grafts with Extracellular Matrix Coatings. Bioengineering (Basel). 2021 Aug 20; 8:
Schwarz EL, Kelly JM, Blum KM, Hor KN, Yates AR, Zbinden JC, Verma A, Lindsey SE, Ramachandra AB, Szafron JM, Humphrey JD, Shin'oka T, Marsden AL, Breuer CK. Publisher Correction: Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients. NPJ Regen Med. 2021 Aug 12; 6: 47.
Liu Y, Feng X, Liu H, McComb DW, Breuer CK, Sacks MS. On the shape and structure of the murine pulmonary heart valve. Sci Rep. 2021 Jul 7; 11: 14078.
Tan ZH, Dharmadhikari S, Liu L, Wolter G, Shontz KM, Reynolds SD, Johnson J, Breuer CK, Chiang T. Tracheal Macrophages During Regeneration and Repair of Long-Segment Airway Defects. Laryngoscope. 2021 Jun 21;
Matsuzaki Y, Miyamoto S, Miyachi H, Iwaki R, Shoji T, Blum K, Chang YC, Kelly J, Reinhardt JW, Nakayama H, Breuer CK, Shinoka T. Improvement of a Novel Small-diameter Tissue-engineered Arterial Graft With Heparin Conjugation. Ann Thorac Surg. 2021 Apr; 111: 1234-1241.
Chang YC, Mirhaidari G, Kelly J, Breuer C. Current Challenges and Solutions to Tissue Engineering of Large-scale Cardiac Constructs. Curr Cardiol Rep. 2021 Mar 17; 23: 47.
Wu YL, Szafron JM, Blum KM, Zbinden JC, Khosravi R, Best CA, Reinhardt JW, Zeng Q, Yi T, Shinoka T, Humphrey JD, Breuer CK, Wang Y. Electrospun Tissue-Engineered Arterial Graft Thickness Affects Long-Term Composition and Mechanics. Tissue Eng Part A. 2020 Sep 30;
Danielson A, Liu L, Shontz KM, Syed H, Dharmadhikari S, Reynolds SD, Breuer CK, Chiang T. Spatial and Temporal Analysis of Host Cells in Tracheal Graft Implantation. Laryngoscope. 2020 Jun 10;
Agarwal R, Blum KM, Musgrave A, Onwuka EA, Yi T, Reinhardt JW, A Best C, Breuer CK. Degradation and in vivo evaluation of polycaprolactone, poly(e-caprolactone-co-L-lactide), and poly-L-lactic acid as scaffold sealant polymers for murine tissue-engineered vascular grafts. Regen Med. 2019 Jul; 14: 627-637.
Szafron JM, B Ramachandra A, Breuer CK, Marsden AL, Humphrey JD. Optimization of Tissue Engineered Vascular Graft Design Using Computational Modeling. Tissue Eng Part C Methods. 2019 Jun 20;
Best CA, Szafron JM, Rocco KA, Zbinden J, Dean EW, Maxfield MW, Kurobe H, Tara S, Bagi PS, Udelsman BV, Khosravi R, Yi T, Shinoka T, Humphrey JD, Breuer CK. Differential outcomes of venous and arterial tissue engineered vascular grafts highlight the importance of coupling long-term implantation studies with computational modeling. Acta Biomater. 2019 Jun 12;
Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.
Dharmadhikari S, Best CA, King N, Henderson M, Johnson J, Breuer CK, Chiang T. Mouse Model of Tracheal Replacement With Electrospun Nanofiber Scaffolds. Ann Otol Rhinol Laryngol. 2019 May; 128: 391-400.
Pepper V, Best CA, Buckley K, Schwartz C, Onwuka E, King N, White A, Dharmadhikari S, Reynolds SD, Johnson J, Grischkan J, Breuer CK, Chiang T. Factors Influencing Poor Outcomes in Synthetic Tissue-Engineered Tracheal Replacement. Otolaryngol Head Neck Surg. 2019 Apr 30; 194599819844754.
Wiet MG, Dharmadhikari S, White A, Reynolds SD, Johnson J, Breuer CK, Chiang T. Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model. J Vis Exp. 2019 Apr 1;
Smith RJ Jr, Yi T, Nasiri B, Breuer CK, Andreadis ST. Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response. FASEB J. 2019 Apr; 33: 5089-5100.
Francom CR, Best CA, Eaton RG, Pepper V, Onwuka AJ, Breuer CK, Merz Lind MN, Grischkan JM, Chiang T. Clinical validation and reproducibility of endoscopic airway measurement in pediatric aerodigestive evaluation. Int J Pediatr Otorhinolaryngol. 2019 Jan; 116: 65-69.
Miyachi H, Reinhardt JW, Otsuru S, Tara S, Nakayama H, Yi T, Lee YU, Miyamoto S, Shoji T, Sugiura T, Breuer CK, Shinoka T. Bone marrow-derived mononuclear cell seeded bioresorbable vascular graft improves acute graft patency by inhibiting thrombus formation via platelet adhesion. Int J Cardiol. 2018 Sep 1; 266: 61-66.
Stacy MR, Best CA, Maxfield MW, Qiu M, Naito Y, Kurobe H, Mahler N, Rocco KA, Sinusas AJ, Shinoka T, Sampath S, Breuer CK. Magnetic Resonance Imaging of Shear Stress and Wall Thickness in Tissue-Engineered Vascular Grafts. Tissue Eng Part C Methods. 2018 Aug; 24: 465-473.
Eichaker L, Li C, King N, Pepper V, Best C, Onwuka E, Heuer E, Zhao K, Grischkan J, Breuer C, Johnson J, Chiang T. Quantification of tissue-engineered trachea performance with computational fluid dynamics. Laryngoscope. 2018 Aug; 128: E272-E279.
Best C, Fukunishi T, Drews J, Khosravi R, Hor K, Mahler N, Yi T, Humphrey JD, Johnson J, Breuer CK, Hibino N. Oversized Biodegradable Arterial Grafts Promote Enhanced Neointimal Tissue Formation. Tissue Eng Part A. 2018 Aug; 24: 1251-1261.
Blum KM, Drews JD, Breuer CK. Tissue-Engineered Heart Valves: A Call for Mechanistic Studies. Tissue Eng Part B Rev. 2018 Jun; 24: 240-253.
Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15; fj201800458.
Relation T, Yi T, Guess AJ, La Perle K, Otsuru S, Hasgur S, Dominici M, Breuer C, Horwitz EM. Intratumoral Delivery of Interferon?-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Stem Cells. 2018 Jun; 36: 915-924.
Onwuka E, King N, Heuer E, Breuer C. The Heart and Great Vessels. Cold Spring Harb Perspect Med. 2018 Mar 1; 8:
Fukunishi T, Best CA, Ong CS, Groehl T, Reinhardt J, Yi T, Miyachi H, Zhang H, Shinoka T, Breuer CK, Johnson J, Hibino N. Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts. Tissue Eng Part A. 2018 Jan; 24: 135-144.
Best C, Strouse R, Hor K, Pepper V, Tipton A, Kelly J, Shinoka T, Breuer C. Toward a patient-specific tissue engineered vascular graft. J Tissue Eng. 2018 Jan-Dec; 9: 2041731418764709.
Best CA, Pepper VK, Ohst D, Bodnyk K, Heuer E, Onwuka EA, King N, Strouse R, Grischkan J, Breuer CK, Johnson J, Chiang T. Designing a tissue-engineered tracheal scaffold for preclinical evaluation. Int J Pediatr Otorhinolaryngol. 2018 Jan; 104: 155-160.
Maxfield MW, Stacy MR, Kurobe H, Tara S, Yi T, Cleary MA, Zhuang ZW, Rodriguez-Davalos MI, Emre SH, Iwakiri Y, Shinoka T, Breuer CK. Novel application and serial evaluation of tissue-engineered portal vein grafts in a murine model. Regen Med. 2017 Dec; 12: 929-938.
Szafron JM, Breuer CK, Wang Y, Humphrey JD. Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts. J Biomech Eng. 2017 Dec 1; 139:
Pepper VK, Onwuka EA, Best CA, King N, Heuer E, Johnson J, Breuer CK, Grischkan JM, Chiang T. Endoscopic management of tissue-engineered tracheal graft stenosis in an ovine model. Laryngoscope. 2017 Oct; 127: 2219-2224.
Sugiura T, Tara S, Nakayama H, Yi T, Lee YU, Shoji T, Breuer CK, Shinoka T. Fast-degrading bioresorbable arterial vascular graft with high cellular infiltration inhibits calcification of the graft. J Vasc Surg. 2017 Jul; 66: 243-250.
Onwuka E, Best C, Sawyer A, Yi T, Heuer E, Sams M, Wiet M, Zheng H, Kyriakides T, Breuer C. The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft. Regen Med. 2017 Apr; 12: 249-261.
Pepper VK, Clark ES, Best CA, Onwuka EA, Sugiura T, Heuer ED, Moko LE, Miyamoto S, Miyachi H, Berman DP, Cheatham SL, Chisolm JL, Shinoka T, Breuer CK, Cheatham JP. Intravascular Ultrasound Characterization of a Tissue-Engineered Vascular Graft in an Ovine Model. J Cardiovasc Transl Res. 2017 Apr; 10: 128-138.
Sugiura T, Agarwal R, Tara S, Yi T, Lee YU, Breuer CK, Weiss AS, Shinoka T. Tropoelastin inhibits intimal hyperplasia of mouse bioresorbable arterial vascular grafts. Acta Biomater. 2017 Apr 1; 52: 74-80.
Fukunishi T, Best CA, Sugiura T, Opfermann J, Ong CS, Shinoka T, Breuer CK, Krieger A, Johnson J, Hibino N. Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model. J Thorac Cardiovasc Surg. 2017 Apr; 153: 924-932.
Best C, Tara S, Wiet M, Reinhardt J, Pepper V, Ball M, Yi T, Shinoka T, Breuer C. Deconstructing the Tissue Engineered Vascular Graft: Evaluating Scaffold Pre-Wetting, Conditioned Media Incubation, and Determining the Optimal Mononuclear Cell Source. ACS Biomater Sci Eng. 2017; 3: 1972-1979.
View More Publications
Education
Date of Appointment at Nationwide Children’s Hospital: 09/28/2012
Board Certifications
Pediatric Surgery
Fellowship
Hasbro Children’s Hospital
Date Completed: 06/30/1999
Fellowship
Harvard Medical School
Date Completed: 06/30/1995
Residency
Rhode Island Hospital
Date Completed: 06/30/1997
Residency
Boston Children’s Hospital
Date Completed: 06/30/1993
Residency
Rhode Island Hospital
Date Completed: 06/30/1992
Medical School
Warren Alpert Medical School of Brown University
Date Completed: 05/28/1990
Contact Information
General Pediatric Surgery
Call us at: (614) 722-3900
Fax us at: (614) 722-3903
Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)
Contact Information
Call us at: (614) 722-3900
Fax us at: (614) 722-3903
General Pediatric SurgeryPediatric Surgery700 Children’s DrColumbus, OH 43205 (map)
Learn more about Christopher K. Breuer
Biography
Christopher K. Breuer, MD, is director of the Center for Regenerative Medicine at Nationwide Children’s Hospital, Nationwide Endowed Chair in Surgical Research and director of Tissue Engineering in The Ohio State University Wexner Medical Center’s new Center for Regenerative Medicine and Cell Based Therapies. His clinical and research interests center on bioengineered tissue for use in surgery. Working with Dr. Toshiharu Shinoka, he was the first in the world to tissue engineer blood vessels and implant them in human infants. Dr. Breuer has many honors recognizing his contributions, including the Jacobsen Promising Investigator Award from the American College of Surgeons which is given to the most innovative young surgical investigator in the country.
See Christopher K. Breuer’s Curriculum Vitae (CV)
Patient Care
Locations
Main Campus of Nationwide Children’s Hospital
Academic and Clinical Areas
Pediatric Surgery
Surgeon Team
Pediatric Surgery Residency
Faculty
Surgical Critical Care Fellowship
Faculty
Pediatric Pelvic Reconstruction Fellowship
Faculty
Pediatric Colorectal Research Fellowship
Faculty
Pediatric Colorectal Fellowship
Faculty
Primary Department
General Pediatric Surgery
Awards, Honors & Organizations
Listed, Best Doctors in America
Research
Tissue engineered vascular grafts are used to create an extracardiac total cavopulmonary connection, from the inferior vena cava to the right pulmonary artery, during the Fontan procedure. The right atrium is isolated from venous return. Venous blood is passively delivered to the right pulmonary artery. Publications
Zbinden JC, Mirhaidari GJM, Blum KM, Musgrave AJ, Reinhardt JW, Breuer CK, Barker JC. The lysosomal trafficking regulator is necessary for normal wound healing. Wound Repair Regen. 2022 Jan; 30: 82-99.
Liu L, Dharmadhikari S, Pouliot RA, Li MM, Minneci PM, Tan Z, Shontz K, Johnson J, Reynolds SD, Breuer CK, Weiss DJ, Chiang T. Modulation of Synthetic Tracheal Grafts with Extracellular Matrix Coatings. Bioengineering (Basel). 2021 Aug 20; 8:
Schwarz EL, Kelly JM, Blum KM, Hor KN, Yates AR, Zbinden JC, Verma A, Lindsey SE, Ramachandra AB, Szafron JM, Humphrey JD, Shin'oka T, Marsden AL, Breuer CK. Publisher Correction: Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients. NPJ Regen Med. 2021 Aug 12; 6: 47.
Liu Y, Feng X, Liu H, McComb DW, Breuer CK, Sacks MS. On the shape and structure of the murine pulmonary heart valve. Sci Rep. 2021 Jul 7; 11: 14078.
Tan ZH, Dharmadhikari S, Liu L, Wolter G, Shontz KM, Reynolds SD, Johnson J, Breuer CK, Chiang T. Tracheal Macrophages During Regeneration and Repair of Long-Segment Airway Defects. Laryngoscope. 2021 Jun 21;
Matsuzaki Y, Miyamoto S, Miyachi H, Iwaki R, Shoji T, Blum K, Chang YC, Kelly J, Reinhardt JW, Nakayama H, Breuer CK, Shinoka T. Improvement of a Novel Small-diameter Tissue-engineered Arterial Graft With Heparin Conjugation. Ann Thorac Surg. 2021 Apr; 111: 1234-1241.
Chang YC, Mirhaidari G, Kelly J, Breuer C. Current Challenges and Solutions to Tissue Engineering of Large-scale Cardiac Constructs. Curr Cardiol Rep. 2021 Mar 17; 23: 47.
Wu YL, Szafron JM, Blum KM, Zbinden JC, Khosravi R, Best CA, Reinhardt JW, Zeng Q, Yi T, Shinoka T, Humphrey JD, Breuer CK, Wang Y. Electrospun Tissue-Engineered Arterial Graft Thickness Affects Long-Term Composition and Mechanics. Tissue Eng Part A. 2020 Sep 30;
Danielson A, Liu L, Shontz KM, Syed H, Dharmadhikari S, Reynolds SD, Breuer CK, Chiang T. Spatial and Temporal Analysis of Host Cells in Tracheal Graft Implantation. Laryngoscope. 2020 Jun 10;
Agarwal R, Blum KM, Musgrave A, Onwuka EA, Yi T, Reinhardt JW, A Best C, Breuer CK. Degradation and in vivo evaluation of polycaprolactone, poly(e-caprolactone-co-L-lactide), and poly-L-lactic acid as scaffold sealant polymers for murine tissue-engineered vascular grafts. Regen Med. 2019 Jul; 14: 627-637.
Szafron JM, B Ramachandra A, Breuer CK, Marsden AL, Humphrey JD. Optimization of Tissue Engineered Vascular Graft Design Using Computational Modeling. Tissue Eng Part C Methods. 2019 Jun 20;
Best CA, Szafron JM, Rocco KA, Zbinden J, Dean EW, Maxfield MW, Kurobe H, Tara S, Bagi PS, Udelsman BV, Khosravi R, Yi T, Shinoka T, Humphrey JD, Breuer CK. Differential outcomes of venous and arterial tissue engineered vascular grafts highlight the importance of coupling long-term implantation studies with computational modeling. Acta Biomater. 2019 Jun 12;
Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.
Dharmadhikari S, Best CA, King N, Henderson M, Johnson J, Breuer CK, Chiang T. Mouse Model of Tracheal Replacement With Electrospun Nanofiber Scaffolds. Ann Otol Rhinol Laryngol. 2019 May; 128: 391-400.
Pepper V, Best CA, Buckley K, Schwartz C, Onwuka E, King N, White A, Dharmadhikari S, Reynolds SD, Johnson J, Grischkan J, Breuer CK, Chiang T. Factors Influencing Poor Outcomes in Synthetic Tissue-Engineered Tracheal Replacement. Otolaryngol Head Neck Surg. 2019 Apr 30; 194599819844754.
Wiet MG, Dharmadhikari S, White A, Reynolds SD, Johnson J, Breuer CK, Chiang T. Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model. J Vis Exp. 2019 Apr 1;
Smith RJ Jr, Yi T, Nasiri B, Breuer CK, Andreadis ST. Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response. FASEB J. 2019 Apr; 33: 5089-5100.
Francom CR, Best CA, Eaton RG, Pepper V, Onwuka AJ, Breuer CK, Merz Lind MN, Grischkan JM, Chiang T. Clinical validation and reproducibility of endoscopic airway measurement in pediatric aerodigestive evaluation. Int J Pediatr Otorhinolaryngol. 2019 Jan; 116: 65-69.
Miyachi H, Reinhardt JW, Otsuru S, Tara S, Nakayama H, Yi T, Lee YU, Miyamoto S, Shoji T, Sugiura T, Breuer CK, Shinoka T. Bone marrow-derived mononuclear cell seeded bioresorbable vascular graft improves acute graft patency by inhibiting thrombus formation via platelet adhesion. Int J Cardiol. 2018 Sep 1; 266: 61-66.
Stacy MR, Best CA, Maxfield MW, Qiu M, Naito Y, Kurobe H, Mahler N, Rocco KA, Sinusas AJ, Shinoka T, Sampath S, Breuer CK. Magnetic Resonance Imaging of Shear Stress and Wall Thickness in Tissue-Engineered Vascular Grafts. Tissue Eng Part C Methods. 2018 Aug; 24: 465-473.
Eichaker L, Li C, King N, Pepper V, Best C, Onwuka E, Heuer E, Zhao K, Grischkan J, Breuer C, Johnson J, Chiang T. Quantification of tissue-engineered trachea performance with computational fluid dynamics. Laryngoscope. 2018 Aug; 128: E272-E279.
Best C, Fukunishi T, Drews J, Khosravi R, Hor K, Mahler N, Yi T, Humphrey JD, Johnson J, Breuer CK, Hibino N. Oversized Biodegradable Arterial Grafts Promote Enhanced Neointimal Tissue Formation. Tissue Eng Part A. 2018 Aug; 24: 1251-1261.
Blum KM, Drews JD, Breuer CK. Tissue-Engineered Heart Valves: A Call for Mechanistic Studies. Tissue Eng Part B Rev. 2018 Jun; 24: 240-253.
Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15; fj201800458.
Relation T, Yi T, Guess AJ, La Perle K, Otsuru S, Hasgur S, Dominici M, Breuer C, Horwitz EM. Intratumoral Delivery of Interferon?-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Stem Cells. 2018 Jun; 36: 915-924.
Onwuka E, King N, Heuer E, Breuer C. The Heart and Great Vessels. Cold Spring Harb Perspect Med. 2018 Mar 1; 8:
Fukunishi T, Best CA, Ong CS, Groehl T, Reinhardt J, Yi T, Miyachi H, Zhang H, Shinoka T, Breuer CK, Johnson J, Hibino N. Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts. Tissue Eng Part A. 2018 Jan; 24: 135-144.
Best C, Strouse R, Hor K, Pepper V, Tipton A, Kelly J, Shinoka T, Breuer C. Toward a patient-specific tissue engineered vascular graft. J Tissue Eng. 2018 Jan-Dec; 9: 2041731418764709.
Best CA, Pepper VK, Ohst D, Bodnyk K, Heuer E, Onwuka EA, King N, Strouse R, Grischkan J, Breuer CK, Johnson J, Chiang T. Designing a tissue-engineered tracheal scaffold for preclinical evaluation. Int J Pediatr Otorhinolaryngol. 2018 Jan; 104: 155-160.
Maxfield MW, Stacy MR, Kurobe H, Tara S, Yi T, Cleary MA, Zhuang ZW, Rodriguez-Davalos MI, Emre SH, Iwakiri Y, Shinoka T, Breuer CK. Novel application and serial evaluation of tissue-engineered portal vein grafts in a murine model. Regen Med. 2017 Dec; 12: 929-938.
Szafron JM, Breuer CK, Wang Y, Humphrey JD. Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts. J Biomech Eng. 2017 Dec 1; 139:
Pepper VK, Onwuka EA, Best CA, King N, Heuer E, Johnson J, Breuer CK, Grischkan JM, Chiang T. Endoscopic management of tissue-engineered tracheal graft stenosis in an ovine model. Laryngoscope. 2017 Oct; 127: 2219-2224.
Sugiura T, Tara S, Nakayama H, Yi T, Lee YU, Shoji T, Breuer CK, Shinoka T. Fast-degrading bioresorbable arterial vascular graft with high cellular infiltration inhibits calcification of the graft. J Vasc Surg. 2017 Jul; 66: 243-250.
Onwuka E, Best C, Sawyer A, Yi T, Heuer E, Sams M, Wiet M, Zheng H, Kyriakides T, Breuer C. The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft. Regen Med. 2017 Apr; 12: 249-261.
Pepper VK, Clark ES, Best CA, Onwuka EA, Sugiura T, Heuer ED, Moko LE, Miyamoto S, Miyachi H, Berman DP, Cheatham SL, Chisolm JL, Shinoka T, Breuer CK, Cheatham JP. Intravascular Ultrasound Characterization of a Tissue-Engineered Vascular Graft in an Ovine Model. J Cardiovasc Transl Res. 2017 Apr; 10: 128-138.
Sugiura T, Agarwal R, Tara S, Yi T, Lee YU, Breuer CK, Weiss AS, Shinoka T. Tropoelastin inhibits intimal hyperplasia of mouse bioresorbable arterial vascular grafts. Acta Biomater. 2017 Apr 1; 52: 74-80.
Fukunishi T, Best CA, Sugiura T, Opfermann J, Ong CS, Shinoka T, Breuer CK, Krieger A, Johnson J, Hibino N. Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model. J Thorac Cardiovasc Surg. 2017 Apr; 153: 924-932.
Best C, Tara S, Wiet M, Reinhardt J, Pepper V, Ball M, Yi T, Shinoka T, Breuer C. Deconstructing the Tissue Engineered Vascular Graft: Evaluating Scaffold Pre-Wetting, Conditioned Media Incubation, and Determining the Optimal Mononuclear Cell Source. ACS Biomater Sci Eng. 2017; 3: 1972-1979.
View More Publications
Education
Date of Appointment at Nationwide Children’s Hospital: 09/28/2012
Board Certifications
Pediatric Surgery
Fellowship
Hasbro Children’s Hospital
Date Completed: 06/30/1999
Fellowship
Harvard Medical School
Date Completed: 06/30/1995
Residency
Rhode Island Hospital
Date Completed: 06/30/1997
Residency
Boston Children’s Hospital
Date Completed: 06/30/1993
Residency
Rhode Island Hospital
Date Completed: 06/30/1992
Medical School
Warren Alpert Medical School of Brown University
Date Completed: 05/28/1990
Contact Information
General Pediatric Surgery
Call us at: (614) 722-3900
Fax us at: (614) 722-3903
Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)
Contact Information
Call us at: (614) 722-3900
Fax us at: (614) 722-3903
General Pediatric SurgeryPediatric Surgery700 Children’s DrColumbus, OH 43205 (map)
Learn more about Christopher K. Breuer
Contact Information
- Call us at:
- (614) 722-3900
- Fax us at:
- (614) 722-3903
- General Pediatric SurgeryPediatric Surgery700 Children’s DrColumbus, OH 43205 (map)
Learn more about Christopher K. Breuer
Biography
Christopher K. Breuer, MD, is director of the Center for Regenerative Medicine at Nationwide Children’s Hospital, Nationwide Endowed Chair in Surgical Research and director of Tissue Engineering in The Ohio State University Wexner Medical Center’s new Center for Regenerative Medicine and Cell Based Therapies. His clinical and research interests center on bioengineered tissue for use in surgery. Working with Dr. Toshiharu Shinoka, he was the first in the world to tissue engineer blood vessels and implant them in human infants. Dr. Breuer has many honors recognizing his contributions, including the Jacobsen Promising Investigator Award from the American College of Surgeons which is given to the most innovative young surgical investigator in the country.
See Christopher K. Breuer’s Curriculum Vitae (CV)
Biography
Christopher K. Breuer, MD, is director of the Center for Regenerative Medicine at Nationwide Children’s Hospital, Nationwide Endowed Chair in Surgical Research and director of Tissue Engineering in The Ohio State University Wexner Medical Center’s new Center for Regenerative Medicine and Cell Based Therapies. His clinical and research interests center on bioengineered tissue for use in surgery. Working with Dr. Toshiharu Shinoka, he was the first in the world to tissue engineer blood vessels and implant them in human infants. Dr. Breuer has many honors recognizing his contributions, including the Jacobsen Promising Investigator Award from the American College of Surgeons which is given to the most innovative young surgical investigator in the country.
See Christopher K. Breuer’s Curriculum Vitae (CV)
Biography
Christopher K. Breuer, MD, is director of the Center for Regenerative Medicine at Nationwide Children’s Hospital, Nationwide Endowed Chair in Surgical Research and director of Tissue Engineering in The Ohio State University Wexner Medical Center’s new Center for Regenerative Medicine and Cell Based Therapies. His clinical and research interests center on bioengineered tissue for use in surgery. Working with Dr. Toshiharu Shinoka, he was the first in the world to tissue engineer blood vessels and implant them in human infants. Dr. Breuer has many honors recognizing his contributions, including the Jacobsen Promising Investigator Award from the American College of Surgeons which is given to the most innovative young surgical investigator in the country.
See Christopher K. Breuer’s Curriculum Vitae (CV)
Christopher K. Breuer, MD, is director of the Center for Regenerative Medicine at Nationwide Children’s Hospital, Nationwide Endowed Chair in Surgical Research and director of Tissue Engineering in The Ohio State University Wexner Medical Center’s new Center for Regenerative Medicine and Cell Based Therapies. His clinical and research interests center on bioengineered tissue for use in surgery. Working with Dr. Toshiharu Shinoka, he was the first in the world to tissue engineer blood vessels and implant them in human infants. Dr. Breuer has many honors recognizing his contributions, including the Jacobsen Promising Investigator Award from the American College of Surgeons which is given to the most innovative young surgical investigator in the country.
See Christopher K. Breuer’s Curriculum Vitae (CV)
Christopher K. Breuer, MD, is director of the Center for Regenerative Medicine at Nationwide Children’s Hospital, Nationwide Endowed Chair in Surgical Research and director of Tissue Engineering in The Ohio State University Wexner Medical Center’s new Center for Regenerative Medicine and Cell Based Therapies. His clinical and research interests center on bioengineered tissue for use in surgery. Working with Dr. Toshiharu Shinoka, he was the first in the world to tissue engineer blood vessels and implant them in human infants. Dr. Breuer has many honors recognizing his contributions, including the Jacobsen Promising Investigator Award from the American College of Surgeons which is given to the most innovative young surgical investigator in the country.
See Christopher K. Breuer’s Curriculum Vitae (CV)
Patient Care
Locations
Main Campus of Nationwide Children’s Hospital
Patient Care
Locations
Main Campus of Nationwide Children’s Hospital
Patient Care
Locations
Main Campus of Nationwide Children’s Hospital
Locations
Main Campus of Nationwide Children’s Hospital
Locations
Main Campus of Nationwide Children’s Hospital
Locations
Main Campus of Nationwide Children’s Hospital
- Main Campus of Nationwide Children’s Hospital
Academic and Clinical Areas
Pediatric Surgery
Surgeon Team
Pediatric Surgery Residency
Faculty
Surgical Critical Care Fellowship
Faculty
Pediatric Pelvic Reconstruction Fellowship
Faculty
Pediatric Colorectal Research Fellowship
Faculty
Pediatric Colorectal Fellowship
Faculty
Primary Department
General Pediatric Surgery
Academic and Clinical Areas
Pediatric Surgery
Surgeon Team
Pediatric Surgery Residency
Faculty
Surgical Critical Care Fellowship
Faculty
Pediatric Pelvic Reconstruction Fellowship
Faculty
Pediatric Colorectal Research Fellowship
Faculty
Pediatric Colorectal Fellowship
Faculty
Primary Department
General Pediatric Surgery
Academic and Clinical Areas
Pediatric Surgery
Surgeon Team
Pediatric Surgery Residency
Faculty
Surgical Critical Care Fellowship
Faculty
Pediatric Pelvic Reconstruction Fellowship
Faculty
Pediatric Colorectal Research Fellowship
Faculty
Pediatric Colorectal Fellowship
Faculty
Primary Department
General Pediatric Surgery
Pediatric Surgery
Surgeon Team
Pediatric Surgery Residency
Faculty
Surgical Critical Care Fellowship
Faculty
Pediatric Pelvic Reconstruction Fellowship
Faculty
Pediatric Colorectal Research Fellowship
Faculty
Pediatric Colorectal Fellowship
Faculty
Primary Department
General Pediatric Surgery
- Pediatric Surgery
- Surgeon Team
- Pediatric Surgery Residency
- Faculty
- Surgical Critical Care Fellowship
- Faculty
- Pediatric Pelvic Reconstruction Fellowship
- Faculty
- Pediatric Colorectal Research Fellowship
- Faculty
- Pediatric Colorectal Fellowship
- Faculty
- Primary Department
- General Pediatric Surgery
Awards, Honors & Organizations
Listed, Best Doctors in America
Awards, Honors & Organizations
Listed, Best Doctors in America
Awards, Honors & Organizations
Listed, Best Doctors in America
Listed, Best Doctors in America
- Listed, Best Doctors in America
Research
Tissue engineered vascular grafts are used to create an extracardiac total cavopulmonary connection, from the inferior vena cava to the right pulmonary artery, during the Fontan procedure. The right atrium is isolated from venous return. Venous blood is passively delivered to the right pulmonary artery. Publications
Zbinden JC, Mirhaidari GJM, Blum KM, Musgrave AJ, Reinhardt JW, Breuer CK, Barker JC. The lysosomal trafficking regulator is necessary for normal wound healing. Wound Repair Regen. 2022 Jan; 30: 82-99.
Liu L, Dharmadhikari S, Pouliot RA, Li MM, Minneci PM, Tan Z, Shontz K, Johnson J, Reynolds SD, Breuer CK, Weiss DJ, Chiang T. Modulation of Synthetic Tracheal Grafts with Extracellular Matrix Coatings. Bioengineering (Basel). 2021 Aug 20; 8:
Schwarz EL, Kelly JM, Blum KM, Hor KN, Yates AR, Zbinden JC, Verma A, Lindsey SE, Ramachandra AB, Szafron JM, Humphrey JD, Shin'oka T, Marsden AL, Breuer CK. Publisher Correction: Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients. NPJ Regen Med. 2021 Aug 12; 6: 47.
Liu Y, Feng X, Liu H, McComb DW, Breuer CK, Sacks MS. On the shape and structure of the murine pulmonary heart valve. Sci Rep. 2021 Jul 7; 11: 14078.
Tan ZH, Dharmadhikari S, Liu L, Wolter G, Shontz KM, Reynolds SD, Johnson J, Breuer CK, Chiang T. Tracheal Macrophages During Regeneration and Repair of Long-Segment Airway Defects. Laryngoscope. 2021 Jun 21;
Matsuzaki Y, Miyamoto S, Miyachi H, Iwaki R, Shoji T, Blum K, Chang YC, Kelly J, Reinhardt JW, Nakayama H, Breuer CK, Shinoka T. Improvement of a Novel Small-diameter Tissue-engineered Arterial Graft With Heparin Conjugation. Ann Thorac Surg. 2021 Apr; 111: 1234-1241.
Chang YC, Mirhaidari G, Kelly J, Breuer C. Current Challenges and Solutions to Tissue Engineering of Large-scale Cardiac Constructs. Curr Cardiol Rep. 2021 Mar 17; 23: 47.
Wu YL, Szafron JM, Blum KM, Zbinden JC, Khosravi R, Best CA, Reinhardt JW, Zeng Q, Yi T, Shinoka T, Humphrey JD, Breuer CK, Wang Y. Electrospun Tissue-Engineered Arterial Graft Thickness Affects Long-Term Composition and Mechanics. Tissue Eng Part A. 2020 Sep 30;
Danielson A, Liu L, Shontz KM, Syed H, Dharmadhikari S, Reynolds SD, Breuer CK, Chiang T. Spatial and Temporal Analysis of Host Cells in Tracheal Graft Implantation. Laryngoscope. 2020 Jun 10;
Agarwal R, Blum KM, Musgrave A, Onwuka EA, Yi T, Reinhardt JW, A Best C, Breuer CK. Degradation and in vivo evaluation of polycaprolactone, poly(e-caprolactone-co-L-lactide), and poly-L-lactic acid as scaffold sealant polymers for murine tissue-engineered vascular grafts. Regen Med. 2019 Jul; 14: 627-637.
Szafron JM, B Ramachandra A, Breuer CK, Marsden AL, Humphrey JD. Optimization of Tissue Engineered Vascular Graft Design Using Computational Modeling. Tissue Eng Part C Methods. 2019 Jun 20;
Best CA, Szafron JM, Rocco KA, Zbinden J, Dean EW, Maxfield MW, Kurobe H, Tara S, Bagi PS, Udelsman BV, Khosravi R, Yi T, Shinoka T, Humphrey JD, Breuer CK. Differential outcomes of venous and arterial tissue engineered vascular grafts highlight the importance of coupling long-term implantation studies with computational modeling. Acta Biomater. 2019 Jun 12;
Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.
Dharmadhikari S, Best CA, King N, Henderson M, Johnson J, Breuer CK, Chiang T. Mouse Model of Tracheal Replacement With Electrospun Nanofiber Scaffolds. Ann Otol Rhinol Laryngol. 2019 May; 128: 391-400.
Pepper V, Best CA, Buckley K, Schwartz C, Onwuka E, King N, White A, Dharmadhikari S, Reynolds SD, Johnson J, Grischkan J, Breuer CK, Chiang T. Factors Influencing Poor Outcomes in Synthetic Tissue-Engineered Tracheal Replacement. Otolaryngol Head Neck Surg. 2019 Apr 30; 194599819844754.
Wiet MG, Dharmadhikari S, White A, Reynolds SD, Johnson J, Breuer CK, Chiang T. Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model. J Vis Exp. 2019 Apr 1;
Smith RJ Jr, Yi T, Nasiri B, Breuer CK, Andreadis ST. Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response. FASEB J. 2019 Apr; 33: 5089-5100.
Francom CR, Best CA, Eaton RG, Pepper V, Onwuka AJ, Breuer CK, Merz Lind MN, Grischkan JM, Chiang T. Clinical validation and reproducibility of endoscopic airway measurement in pediatric aerodigestive evaluation. Int J Pediatr Otorhinolaryngol. 2019 Jan; 116: 65-69.
Miyachi H, Reinhardt JW, Otsuru S, Tara S, Nakayama H, Yi T, Lee YU, Miyamoto S, Shoji T, Sugiura T, Breuer CK, Shinoka T. Bone marrow-derived mononuclear cell seeded bioresorbable vascular graft improves acute graft patency by inhibiting thrombus formation via platelet adhesion. Int J Cardiol. 2018 Sep 1; 266: 61-66.
Stacy MR, Best CA, Maxfield MW, Qiu M, Naito Y, Kurobe H, Mahler N, Rocco KA, Sinusas AJ, Shinoka T, Sampath S, Breuer CK. Magnetic Resonance Imaging of Shear Stress and Wall Thickness in Tissue-Engineered Vascular Grafts. Tissue Eng Part C Methods. 2018 Aug; 24: 465-473.
Eichaker L, Li C, King N, Pepper V, Best C, Onwuka E, Heuer E, Zhao K, Grischkan J, Breuer C, Johnson J, Chiang T. Quantification of tissue-engineered trachea performance with computational fluid dynamics. Laryngoscope. 2018 Aug; 128: E272-E279.
Best C, Fukunishi T, Drews J, Khosravi R, Hor K, Mahler N, Yi T, Humphrey JD, Johnson J, Breuer CK, Hibino N. Oversized Biodegradable Arterial Grafts Promote Enhanced Neointimal Tissue Formation. Tissue Eng Part A. 2018 Aug; 24: 1251-1261.
Blum KM, Drews JD, Breuer CK. Tissue-Engineered Heart Valves: A Call for Mechanistic Studies. Tissue Eng Part B Rev. 2018 Jun; 24: 240-253.
Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15; fj201800458.
Relation T, Yi T, Guess AJ, La Perle K, Otsuru S, Hasgur S, Dominici M, Breuer C, Horwitz EM. Intratumoral Delivery of Interferon?-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Stem Cells. 2018 Jun; 36: 915-924.
Onwuka E, King N, Heuer E, Breuer C. The Heart and Great Vessels. Cold Spring Harb Perspect Med. 2018 Mar 1; 8:
Fukunishi T, Best CA, Ong CS, Groehl T, Reinhardt J, Yi T, Miyachi H, Zhang H, Shinoka T, Breuer CK, Johnson J, Hibino N. Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts. Tissue Eng Part A. 2018 Jan; 24: 135-144.
Best C, Strouse R, Hor K, Pepper V, Tipton A, Kelly J, Shinoka T, Breuer C. Toward a patient-specific tissue engineered vascular graft. J Tissue Eng. 2018 Jan-Dec; 9: 2041731418764709.
Best CA, Pepper VK, Ohst D, Bodnyk K, Heuer E, Onwuka EA, King N, Strouse R, Grischkan J, Breuer CK, Johnson J, Chiang T. Designing a tissue-engineered tracheal scaffold for preclinical evaluation. Int J Pediatr Otorhinolaryngol. 2018 Jan; 104: 155-160.
Maxfield MW, Stacy MR, Kurobe H, Tara S, Yi T, Cleary MA, Zhuang ZW, Rodriguez-Davalos MI, Emre SH, Iwakiri Y, Shinoka T, Breuer CK. Novel application and serial evaluation of tissue-engineered portal vein grafts in a murine model. Regen Med. 2017 Dec; 12: 929-938.
Szafron JM, Breuer CK, Wang Y, Humphrey JD. Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts. J Biomech Eng. 2017 Dec 1; 139:
Pepper VK, Onwuka EA, Best CA, King N, Heuer E, Johnson J, Breuer CK, Grischkan JM, Chiang T. Endoscopic management of tissue-engineered tracheal graft stenosis in an ovine model. Laryngoscope. 2017 Oct; 127: 2219-2224.
Sugiura T, Tara S, Nakayama H, Yi T, Lee YU, Shoji T, Breuer CK, Shinoka T. Fast-degrading bioresorbable arterial vascular graft with high cellular infiltration inhibits calcification of the graft. J Vasc Surg. 2017 Jul; 66: 243-250.
Onwuka E, Best C, Sawyer A, Yi T, Heuer E, Sams M, Wiet M, Zheng H, Kyriakides T, Breuer C. The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft. Regen Med. 2017 Apr; 12: 249-261.
Pepper VK, Clark ES, Best CA, Onwuka EA, Sugiura T, Heuer ED, Moko LE, Miyamoto S, Miyachi H, Berman DP, Cheatham SL, Chisolm JL, Shinoka T, Breuer CK, Cheatham JP. Intravascular Ultrasound Characterization of a Tissue-Engineered Vascular Graft in an Ovine Model. J Cardiovasc Transl Res. 2017 Apr; 10: 128-138.
Sugiura T, Agarwal R, Tara S, Yi T, Lee YU, Breuer CK, Weiss AS, Shinoka T. Tropoelastin inhibits intimal hyperplasia of mouse bioresorbable arterial vascular grafts. Acta Biomater. 2017 Apr 1; 52: 74-80.
Fukunishi T, Best CA, Sugiura T, Opfermann J, Ong CS, Shinoka T, Breuer CK, Krieger A, Johnson J, Hibino N. Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model. J Thorac Cardiovasc Surg. 2017 Apr; 153: 924-932.
Best C, Tara S, Wiet M, Reinhardt J, Pepper V, Ball M, Yi T, Shinoka T, Breuer C. Deconstructing the Tissue Engineered Vascular Graft: Evaluating Scaffold Pre-Wetting, Conditioned Media Incubation, and Determining the Optimal Mononuclear Cell Source. ACS Biomater Sci Eng. 2017; 3: 1972-1979.
View More Publications
Research
Tissue engineered vascular grafts are used to create an extracardiac total cavopulmonary connection, from the inferior vena cava to the right pulmonary artery, during the Fontan procedure. The right atrium is isolated from venous return. Venous blood is passively delivered to the right pulmonary artery. Publications
Zbinden JC, Mirhaidari GJM, Blum KM, Musgrave AJ, Reinhardt JW, Breuer CK, Barker JC. The lysosomal trafficking regulator is necessary for normal wound healing. Wound Repair Regen. 2022 Jan; 30: 82-99.
Liu L, Dharmadhikari S, Pouliot RA, Li MM, Minneci PM, Tan Z, Shontz K, Johnson J, Reynolds SD, Breuer CK, Weiss DJ, Chiang T. Modulation of Synthetic Tracheal Grafts with Extracellular Matrix Coatings. Bioengineering (Basel). 2021 Aug 20; 8:
Schwarz EL, Kelly JM, Blum KM, Hor KN, Yates AR, Zbinden JC, Verma A, Lindsey SE, Ramachandra AB, Szafron JM, Humphrey JD, Shin'oka T, Marsden AL, Breuer CK. Publisher Correction: Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients. NPJ Regen Med. 2021 Aug 12; 6: 47.
Liu Y, Feng X, Liu H, McComb DW, Breuer CK, Sacks MS. On the shape and structure of the murine pulmonary heart valve. Sci Rep. 2021 Jul 7; 11: 14078.
Tan ZH, Dharmadhikari S, Liu L, Wolter G, Shontz KM, Reynolds SD, Johnson J, Breuer CK, Chiang T. Tracheal Macrophages During Regeneration and Repair of Long-Segment Airway Defects. Laryngoscope. 2021 Jun 21;
Matsuzaki Y, Miyamoto S, Miyachi H, Iwaki R, Shoji T, Blum K, Chang YC, Kelly J, Reinhardt JW, Nakayama H, Breuer CK, Shinoka T. Improvement of a Novel Small-diameter Tissue-engineered Arterial Graft With Heparin Conjugation. Ann Thorac Surg. 2021 Apr; 111: 1234-1241.
Chang YC, Mirhaidari G, Kelly J, Breuer C. Current Challenges and Solutions to Tissue Engineering of Large-scale Cardiac Constructs. Curr Cardiol Rep. 2021 Mar 17; 23: 47.
Wu YL, Szafron JM, Blum KM, Zbinden JC, Khosravi R, Best CA, Reinhardt JW, Zeng Q, Yi T, Shinoka T, Humphrey JD, Breuer CK, Wang Y. Electrospun Tissue-Engineered Arterial Graft Thickness Affects Long-Term Composition and Mechanics. Tissue Eng Part A. 2020 Sep 30;
Danielson A, Liu L, Shontz KM, Syed H, Dharmadhikari S, Reynolds SD, Breuer CK, Chiang T. Spatial and Temporal Analysis of Host Cells in Tracheal Graft Implantation. Laryngoscope. 2020 Jun 10;
Agarwal R, Blum KM, Musgrave A, Onwuka EA, Yi T, Reinhardt JW, A Best C, Breuer CK. Degradation and in vivo evaluation of polycaprolactone, poly(e-caprolactone-co-L-lactide), and poly-L-lactic acid as scaffold sealant polymers for murine tissue-engineered vascular grafts. Regen Med. 2019 Jul; 14: 627-637.
Szafron JM, B Ramachandra A, Breuer CK, Marsden AL, Humphrey JD. Optimization of Tissue Engineered Vascular Graft Design Using Computational Modeling. Tissue Eng Part C Methods. 2019 Jun 20;
Best CA, Szafron JM, Rocco KA, Zbinden J, Dean EW, Maxfield MW, Kurobe H, Tara S, Bagi PS, Udelsman BV, Khosravi R, Yi T, Shinoka T, Humphrey JD, Breuer CK. Differential outcomes of venous and arterial tissue engineered vascular grafts highlight the importance of coupling long-term implantation studies with computational modeling. Acta Biomater. 2019 Jun 12;
Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.
Dharmadhikari S, Best CA, King N, Henderson M, Johnson J, Breuer CK, Chiang T. Mouse Model of Tracheal Replacement With Electrospun Nanofiber Scaffolds. Ann Otol Rhinol Laryngol. 2019 May; 128: 391-400.
Pepper V, Best CA, Buckley K, Schwartz C, Onwuka E, King N, White A, Dharmadhikari S, Reynolds SD, Johnson J, Grischkan J, Breuer CK, Chiang T. Factors Influencing Poor Outcomes in Synthetic Tissue-Engineered Tracheal Replacement. Otolaryngol Head Neck Surg. 2019 Apr 30; 194599819844754.
Wiet MG, Dharmadhikari S, White A, Reynolds SD, Johnson J, Breuer CK, Chiang T. Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model. J Vis Exp. 2019 Apr 1;
Smith RJ Jr, Yi T, Nasiri B, Breuer CK, Andreadis ST. Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response. FASEB J. 2019 Apr; 33: 5089-5100.
Francom CR, Best CA, Eaton RG, Pepper V, Onwuka AJ, Breuer CK, Merz Lind MN, Grischkan JM, Chiang T. Clinical validation and reproducibility of endoscopic airway measurement in pediatric aerodigestive evaluation. Int J Pediatr Otorhinolaryngol. 2019 Jan; 116: 65-69.
Miyachi H, Reinhardt JW, Otsuru S, Tara S, Nakayama H, Yi T, Lee YU, Miyamoto S, Shoji T, Sugiura T, Breuer CK, Shinoka T. Bone marrow-derived mononuclear cell seeded bioresorbable vascular graft improves acute graft patency by inhibiting thrombus formation via platelet adhesion. Int J Cardiol. 2018 Sep 1; 266: 61-66.
Stacy MR, Best CA, Maxfield MW, Qiu M, Naito Y, Kurobe H, Mahler N, Rocco KA, Sinusas AJ, Shinoka T, Sampath S, Breuer CK. Magnetic Resonance Imaging of Shear Stress and Wall Thickness in Tissue-Engineered Vascular Grafts. Tissue Eng Part C Methods. 2018 Aug; 24: 465-473.
Eichaker L, Li C, King N, Pepper V, Best C, Onwuka E, Heuer E, Zhao K, Grischkan J, Breuer C, Johnson J, Chiang T. Quantification of tissue-engineered trachea performance with computational fluid dynamics. Laryngoscope. 2018 Aug; 128: E272-E279.
Best C, Fukunishi T, Drews J, Khosravi R, Hor K, Mahler N, Yi T, Humphrey JD, Johnson J, Breuer CK, Hibino N. Oversized Biodegradable Arterial Grafts Promote Enhanced Neointimal Tissue Formation. Tissue Eng Part A. 2018 Aug; 24: 1251-1261.
Blum KM, Drews JD, Breuer CK. Tissue-Engineered Heart Valves: A Call for Mechanistic Studies. Tissue Eng Part B Rev. 2018 Jun; 24: 240-253.
Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15; fj201800458.
Relation T, Yi T, Guess AJ, La Perle K, Otsuru S, Hasgur S, Dominici M, Breuer C, Horwitz EM. Intratumoral Delivery of Interferon?-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Stem Cells. 2018 Jun; 36: 915-924.
Onwuka E, King N, Heuer E, Breuer C. The Heart and Great Vessels. Cold Spring Harb Perspect Med. 2018 Mar 1; 8:
Fukunishi T, Best CA, Ong CS, Groehl T, Reinhardt J, Yi T, Miyachi H, Zhang H, Shinoka T, Breuer CK, Johnson J, Hibino N. Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts. Tissue Eng Part A. 2018 Jan; 24: 135-144.
Best C, Strouse R, Hor K, Pepper V, Tipton A, Kelly J, Shinoka T, Breuer C. Toward a patient-specific tissue engineered vascular graft. J Tissue Eng. 2018 Jan-Dec; 9: 2041731418764709.
Best CA, Pepper VK, Ohst D, Bodnyk K, Heuer E, Onwuka EA, King N, Strouse R, Grischkan J, Breuer CK, Johnson J, Chiang T. Designing a tissue-engineered tracheal scaffold for preclinical evaluation. Int J Pediatr Otorhinolaryngol. 2018 Jan; 104: 155-160.
Maxfield MW, Stacy MR, Kurobe H, Tara S, Yi T, Cleary MA, Zhuang ZW, Rodriguez-Davalos MI, Emre SH, Iwakiri Y, Shinoka T, Breuer CK. Novel application and serial evaluation of tissue-engineered portal vein grafts in a murine model. Regen Med. 2017 Dec; 12: 929-938.
Szafron JM, Breuer CK, Wang Y, Humphrey JD. Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts. J Biomech Eng. 2017 Dec 1; 139:
Pepper VK, Onwuka EA, Best CA, King N, Heuer E, Johnson J, Breuer CK, Grischkan JM, Chiang T. Endoscopic management of tissue-engineered tracheal graft stenosis in an ovine model. Laryngoscope. 2017 Oct; 127: 2219-2224.
Sugiura T, Tara S, Nakayama H, Yi T, Lee YU, Shoji T, Breuer CK, Shinoka T. Fast-degrading bioresorbable arterial vascular graft with high cellular infiltration inhibits calcification of the graft. J Vasc Surg. 2017 Jul; 66: 243-250.
Onwuka E, Best C, Sawyer A, Yi T, Heuer E, Sams M, Wiet M, Zheng H, Kyriakides T, Breuer C. The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft. Regen Med. 2017 Apr; 12: 249-261.
Pepper VK, Clark ES, Best CA, Onwuka EA, Sugiura T, Heuer ED, Moko LE, Miyamoto S, Miyachi H, Berman DP, Cheatham SL, Chisolm JL, Shinoka T, Breuer CK, Cheatham JP. Intravascular Ultrasound Characterization of a Tissue-Engineered Vascular Graft in an Ovine Model. J Cardiovasc Transl Res. 2017 Apr; 10: 128-138.
Sugiura T, Agarwal R, Tara S, Yi T, Lee YU, Breuer CK, Weiss AS, Shinoka T. Tropoelastin inhibits intimal hyperplasia of mouse bioresorbable arterial vascular grafts. Acta Biomater. 2017 Apr 1; 52: 74-80.
Fukunishi T, Best CA, Sugiura T, Opfermann J, Ong CS, Shinoka T, Breuer CK, Krieger A, Johnson J, Hibino N. Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model. J Thorac Cardiovasc Surg. 2017 Apr; 153: 924-932.
Best C, Tara S, Wiet M, Reinhardt J, Pepper V, Ball M, Yi T, Shinoka T, Breuer C. Deconstructing the Tissue Engineered Vascular Graft: Evaluating Scaffold Pre-Wetting, Conditioned Media Incubation, and Determining the Optimal Mononuclear Cell Source. ACS Biomater Sci Eng. 2017; 3: 1972-1979.
View More Publications
Research
Tissue engineered vascular grafts are used to create an extracardiac total cavopulmonary connection, from the inferior vena cava to the right pulmonary artery, during the Fontan procedure. The right atrium is isolated from venous return. Venous blood is passively delivered to the right pulmonary artery. Publications
Zbinden JC, Mirhaidari GJM, Blum KM, Musgrave AJ, Reinhardt JW, Breuer CK, Barker JC. The lysosomal trafficking regulator is necessary for normal wound healing. Wound Repair Regen. 2022 Jan; 30: 82-99.
Liu L, Dharmadhikari S, Pouliot RA, Li MM, Minneci PM, Tan Z, Shontz K, Johnson J, Reynolds SD, Breuer CK, Weiss DJ, Chiang T. Modulation of Synthetic Tracheal Grafts with Extracellular Matrix Coatings. Bioengineering (Basel). 2021 Aug 20; 8:
Schwarz EL, Kelly JM, Blum KM, Hor KN, Yates AR, Zbinden JC, Verma A, Lindsey SE, Ramachandra AB, Szafron JM, Humphrey JD, Shin'oka T, Marsden AL, Breuer CK. Publisher Correction: Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients. NPJ Regen Med. 2021 Aug 12; 6: 47.
Liu Y, Feng X, Liu H, McComb DW, Breuer CK, Sacks MS. On the shape and structure of the murine pulmonary heart valve. Sci Rep. 2021 Jul 7; 11: 14078.
Tan ZH, Dharmadhikari S, Liu L, Wolter G, Shontz KM, Reynolds SD, Johnson J, Breuer CK, Chiang T. Tracheal Macrophages During Regeneration and Repair of Long-Segment Airway Defects. Laryngoscope. 2021 Jun 21;
Matsuzaki Y, Miyamoto S, Miyachi H, Iwaki R, Shoji T, Blum K, Chang YC, Kelly J, Reinhardt JW, Nakayama H, Breuer CK, Shinoka T. Improvement of a Novel Small-diameter Tissue-engineered Arterial Graft With Heparin Conjugation. Ann Thorac Surg. 2021 Apr; 111: 1234-1241.
Chang YC, Mirhaidari G, Kelly J, Breuer C. Current Challenges and Solutions to Tissue Engineering of Large-scale Cardiac Constructs. Curr Cardiol Rep. 2021 Mar 17; 23: 47.
Wu YL, Szafron JM, Blum KM, Zbinden JC, Khosravi R, Best CA, Reinhardt JW, Zeng Q, Yi T, Shinoka T, Humphrey JD, Breuer CK, Wang Y. Electrospun Tissue-Engineered Arterial Graft Thickness Affects Long-Term Composition and Mechanics. Tissue Eng Part A. 2020 Sep 30;
Danielson A, Liu L, Shontz KM, Syed H, Dharmadhikari S, Reynolds SD, Breuer CK, Chiang T. Spatial and Temporal Analysis of Host Cells in Tracheal Graft Implantation. Laryngoscope. 2020 Jun 10;
Agarwal R, Blum KM, Musgrave A, Onwuka EA, Yi T, Reinhardt JW, A Best C, Breuer CK. Degradation and in vivo evaluation of polycaprolactone, poly(e-caprolactone-co-L-lactide), and poly-L-lactic acid as scaffold sealant polymers for murine tissue-engineered vascular grafts. Regen Med. 2019 Jul; 14: 627-637.
Szafron JM, B Ramachandra A, Breuer CK, Marsden AL, Humphrey JD. Optimization of Tissue Engineered Vascular Graft Design Using Computational Modeling. Tissue Eng Part C Methods. 2019 Jun 20;
Best CA, Szafron JM, Rocco KA, Zbinden J, Dean EW, Maxfield MW, Kurobe H, Tara S, Bagi PS, Udelsman BV, Khosravi R, Yi T, Shinoka T, Humphrey JD, Breuer CK. Differential outcomes of venous and arterial tissue engineered vascular grafts highlight the importance of coupling long-term implantation studies with computational modeling. Acta Biomater. 2019 Jun 12;
Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.
Dharmadhikari S, Best CA, King N, Henderson M, Johnson J, Breuer CK, Chiang T. Mouse Model of Tracheal Replacement With Electrospun Nanofiber Scaffolds. Ann Otol Rhinol Laryngol. 2019 May; 128: 391-400.
Pepper V, Best CA, Buckley K, Schwartz C, Onwuka E, King N, White A, Dharmadhikari S, Reynolds SD, Johnson J, Grischkan J, Breuer CK, Chiang T. Factors Influencing Poor Outcomes in Synthetic Tissue-Engineered Tracheal Replacement. Otolaryngol Head Neck Surg. 2019 Apr 30; 194599819844754.
Wiet MG, Dharmadhikari S, White A, Reynolds SD, Johnson J, Breuer CK, Chiang T. Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model. J Vis Exp. 2019 Apr 1;
Smith RJ Jr, Yi T, Nasiri B, Breuer CK, Andreadis ST. Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response. FASEB J. 2019 Apr; 33: 5089-5100.
Francom CR, Best CA, Eaton RG, Pepper V, Onwuka AJ, Breuer CK, Merz Lind MN, Grischkan JM, Chiang T. Clinical validation and reproducibility of endoscopic airway measurement in pediatric aerodigestive evaluation. Int J Pediatr Otorhinolaryngol. 2019 Jan; 116: 65-69.
Miyachi H, Reinhardt JW, Otsuru S, Tara S, Nakayama H, Yi T, Lee YU, Miyamoto S, Shoji T, Sugiura T, Breuer CK, Shinoka T. Bone marrow-derived mononuclear cell seeded bioresorbable vascular graft improves acute graft patency by inhibiting thrombus formation via platelet adhesion. Int J Cardiol. 2018 Sep 1; 266: 61-66.
Stacy MR, Best CA, Maxfield MW, Qiu M, Naito Y, Kurobe H, Mahler N, Rocco KA, Sinusas AJ, Shinoka T, Sampath S, Breuer CK. Magnetic Resonance Imaging of Shear Stress and Wall Thickness in Tissue-Engineered Vascular Grafts. Tissue Eng Part C Methods. 2018 Aug; 24: 465-473.
Eichaker L, Li C, King N, Pepper V, Best C, Onwuka E, Heuer E, Zhao K, Grischkan J, Breuer C, Johnson J, Chiang T. Quantification of tissue-engineered trachea performance with computational fluid dynamics. Laryngoscope. 2018 Aug; 128: E272-E279.
Best C, Fukunishi T, Drews J, Khosravi R, Hor K, Mahler N, Yi T, Humphrey JD, Johnson J, Breuer CK, Hibino N. Oversized Biodegradable Arterial Grafts Promote Enhanced Neointimal Tissue Formation. Tissue Eng Part A. 2018 Aug; 24: 1251-1261.
Blum KM, Drews JD, Breuer CK. Tissue-Engineered Heart Valves: A Call for Mechanistic Studies. Tissue Eng Part B Rev. 2018 Jun; 24: 240-253.
Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15; fj201800458.
Relation T, Yi T, Guess AJ, La Perle K, Otsuru S, Hasgur S, Dominici M, Breuer C, Horwitz EM. Intratumoral Delivery of Interferon?-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Stem Cells. 2018 Jun; 36: 915-924.
Onwuka E, King N, Heuer E, Breuer C. The Heart and Great Vessels. Cold Spring Harb Perspect Med. 2018 Mar 1; 8:
Fukunishi T, Best CA, Ong CS, Groehl T, Reinhardt J, Yi T, Miyachi H, Zhang H, Shinoka T, Breuer CK, Johnson J, Hibino N. Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts. Tissue Eng Part A. 2018 Jan; 24: 135-144.
Best C, Strouse R, Hor K, Pepper V, Tipton A, Kelly J, Shinoka T, Breuer C. Toward a patient-specific tissue engineered vascular graft. J Tissue Eng. 2018 Jan-Dec; 9: 2041731418764709.
Best CA, Pepper VK, Ohst D, Bodnyk K, Heuer E, Onwuka EA, King N, Strouse R, Grischkan J, Breuer CK, Johnson J, Chiang T. Designing a tissue-engineered tracheal scaffold for preclinical evaluation. Int J Pediatr Otorhinolaryngol. 2018 Jan; 104: 155-160.
Maxfield MW, Stacy MR, Kurobe H, Tara S, Yi T, Cleary MA, Zhuang ZW, Rodriguez-Davalos MI, Emre SH, Iwakiri Y, Shinoka T, Breuer CK. Novel application and serial evaluation of tissue-engineered portal vein grafts in a murine model. Regen Med. 2017 Dec; 12: 929-938.
Szafron JM, Breuer CK, Wang Y, Humphrey JD. Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts. J Biomech Eng. 2017 Dec 1; 139:
Pepper VK, Onwuka EA, Best CA, King N, Heuer E, Johnson J, Breuer CK, Grischkan JM, Chiang T. Endoscopic management of tissue-engineered tracheal graft stenosis in an ovine model. Laryngoscope. 2017 Oct; 127: 2219-2224.
Sugiura T, Tara S, Nakayama H, Yi T, Lee YU, Shoji T, Breuer CK, Shinoka T. Fast-degrading bioresorbable arterial vascular graft with high cellular infiltration inhibits calcification of the graft. J Vasc Surg. 2017 Jul; 66: 243-250.
Onwuka E, Best C, Sawyer A, Yi T, Heuer E, Sams M, Wiet M, Zheng H, Kyriakides T, Breuer C. The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft. Regen Med. 2017 Apr; 12: 249-261.
Pepper VK, Clark ES, Best CA, Onwuka EA, Sugiura T, Heuer ED, Moko LE, Miyamoto S, Miyachi H, Berman DP, Cheatham SL, Chisolm JL, Shinoka T, Breuer CK, Cheatham JP. Intravascular Ultrasound Characterization of a Tissue-Engineered Vascular Graft in an Ovine Model. J Cardiovasc Transl Res. 2017 Apr; 10: 128-138.
Sugiura T, Agarwal R, Tara S, Yi T, Lee YU, Breuer CK, Weiss AS, Shinoka T. Tropoelastin inhibits intimal hyperplasia of mouse bioresorbable arterial vascular grafts. Acta Biomater. 2017 Apr 1; 52: 74-80.
Fukunishi T, Best CA, Sugiura T, Opfermann J, Ong CS, Shinoka T, Breuer CK, Krieger A, Johnson J, Hibino N. Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model. J Thorac Cardiovasc Surg. 2017 Apr; 153: 924-932.
Best C, Tara S, Wiet M, Reinhardt J, Pepper V, Ball M, Yi T, Shinoka T, Breuer C. Deconstructing the Tissue Engineered Vascular Graft: Evaluating Scaffold Pre-Wetting, Conditioned Media Incubation, and Determining the Optimal Mononuclear Cell Source. ACS Biomater Sci Eng. 2017; 3: 1972-1979.
View More Publications
Tissue engineered vascular grafts are used to create an extracardiac total cavopulmonary connection, from the inferior vena cava to the right pulmonary artery, during the Fontan procedure. The right atrium is isolated from venous return. Venous blood is passively delivered to the right pulmonary artery. Publications
Zbinden JC, Mirhaidari GJM, Blum KM, Musgrave AJ, Reinhardt JW, Breuer CK, Barker JC. The lysosomal trafficking regulator is necessary for normal wound healing. Wound Repair Regen. 2022 Jan; 30: 82-99.
Liu L, Dharmadhikari S, Pouliot RA, Li MM, Minneci PM, Tan Z, Shontz K, Johnson J, Reynolds SD, Breuer CK, Weiss DJ, Chiang T. Modulation of Synthetic Tracheal Grafts with Extracellular Matrix Coatings. Bioengineering (Basel). 2021 Aug 20; 8:
Schwarz EL, Kelly JM, Blum KM, Hor KN, Yates AR, Zbinden JC, Verma A, Lindsey SE, Ramachandra AB, Szafron JM, Humphrey JD, Shin'oka T, Marsden AL, Breuer CK. Publisher Correction: Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients. NPJ Regen Med. 2021 Aug 12; 6: 47.
Liu Y, Feng X, Liu H, McComb DW, Breuer CK, Sacks MS. On the shape and structure of the murine pulmonary heart valve. Sci Rep. 2021 Jul 7; 11: 14078.
Tan ZH, Dharmadhikari S, Liu L, Wolter G, Shontz KM, Reynolds SD, Johnson J, Breuer CK, Chiang T. Tracheal Macrophages During Regeneration and Repair of Long-Segment Airway Defects. Laryngoscope. 2021 Jun 21;
Matsuzaki Y, Miyamoto S, Miyachi H, Iwaki R, Shoji T, Blum K, Chang YC, Kelly J, Reinhardt JW, Nakayama H, Breuer CK, Shinoka T. Improvement of a Novel Small-diameter Tissue-engineered Arterial Graft With Heparin Conjugation. Ann Thorac Surg. 2021 Apr; 111: 1234-1241.
Chang YC, Mirhaidari G, Kelly J, Breuer C. Current Challenges and Solutions to Tissue Engineering of Large-scale Cardiac Constructs. Curr Cardiol Rep. 2021 Mar 17; 23: 47.
Wu YL, Szafron JM, Blum KM, Zbinden JC, Khosravi R, Best CA, Reinhardt JW, Zeng Q, Yi T, Shinoka T, Humphrey JD, Breuer CK, Wang Y. Electrospun Tissue-Engineered Arterial Graft Thickness Affects Long-Term Composition and Mechanics. Tissue Eng Part A. 2020 Sep 30;
Danielson A, Liu L, Shontz KM, Syed H, Dharmadhikari S, Reynolds SD, Breuer CK, Chiang T. Spatial and Temporal Analysis of Host Cells in Tracheal Graft Implantation. Laryngoscope. 2020 Jun 10;
Agarwal R, Blum KM, Musgrave A, Onwuka EA, Yi T, Reinhardt JW, A Best C, Breuer CK. Degradation and in vivo evaluation of polycaprolactone, poly(e-caprolactone-co-L-lactide), and poly-L-lactic acid as scaffold sealant polymers for murine tissue-engineered vascular grafts. Regen Med. 2019 Jul; 14: 627-637.
Szafron JM, B Ramachandra A, Breuer CK, Marsden AL, Humphrey JD. Optimization of Tissue Engineered Vascular Graft Design Using Computational Modeling. Tissue Eng Part C Methods. 2019 Jun 20;
Best CA, Szafron JM, Rocco KA, Zbinden J, Dean EW, Maxfield MW, Kurobe H, Tara S, Bagi PS, Udelsman BV, Khosravi R, Yi T, Shinoka T, Humphrey JD, Breuer CK. Differential outcomes of venous and arterial tissue engineered vascular grafts highlight the importance of coupling long-term implantation studies with computational modeling. Acta Biomater. 2019 Jun 12;
Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.
Dharmadhikari S, Best CA, King N, Henderson M, Johnson J, Breuer CK, Chiang T. Mouse Model of Tracheal Replacement With Electrospun Nanofiber Scaffolds. Ann Otol Rhinol Laryngol. 2019 May; 128: 391-400.
Pepper V, Best CA, Buckley K, Schwartz C, Onwuka E, King N, White A, Dharmadhikari S, Reynolds SD, Johnson J, Grischkan J, Breuer CK, Chiang T. Factors Influencing Poor Outcomes in Synthetic Tissue-Engineered Tracheal Replacement. Otolaryngol Head Neck Surg. 2019 Apr 30; 194599819844754.
Wiet MG, Dharmadhikari S, White A, Reynolds SD, Johnson J, Breuer CK, Chiang T. Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model. J Vis Exp. 2019 Apr 1;
Smith RJ Jr, Yi T, Nasiri B, Breuer CK, Andreadis ST. Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response. FASEB J. 2019 Apr; 33: 5089-5100.
Francom CR, Best CA, Eaton RG, Pepper V, Onwuka AJ, Breuer CK, Merz Lind MN, Grischkan JM, Chiang T. Clinical validation and reproducibility of endoscopic airway measurement in pediatric aerodigestive evaluation. Int J Pediatr Otorhinolaryngol. 2019 Jan; 116: 65-69.
Miyachi H, Reinhardt JW, Otsuru S, Tara S, Nakayama H, Yi T, Lee YU, Miyamoto S, Shoji T, Sugiura T, Breuer CK, Shinoka T. Bone marrow-derived mononuclear cell seeded bioresorbable vascular graft improves acute graft patency by inhibiting thrombus formation via platelet adhesion. Int J Cardiol. 2018 Sep 1; 266: 61-66.
Stacy MR, Best CA, Maxfield MW, Qiu M, Naito Y, Kurobe H, Mahler N, Rocco KA, Sinusas AJ, Shinoka T, Sampath S, Breuer CK. Magnetic Resonance Imaging of Shear Stress and Wall Thickness in Tissue-Engineered Vascular Grafts. Tissue Eng Part C Methods. 2018 Aug; 24: 465-473.
Eichaker L, Li C, King N, Pepper V, Best C, Onwuka E, Heuer E, Zhao K, Grischkan J, Breuer C, Johnson J, Chiang T. Quantification of tissue-engineered trachea performance with computational fluid dynamics. Laryngoscope. 2018 Aug; 128: E272-E279.
Best C, Fukunishi T, Drews J, Khosravi R, Hor K, Mahler N, Yi T, Humphrey JD, Johnson J, Breuer CK, Hibino N. Oversized Biodegradable Arterial Grafts Promote Enhanced Neointimal Tissue Formation. Tissue Eng Part A. 2018 Aug; 24: 1251-1261.
Blum KM, Drews JD, Breuer CK. Tissue-Engineered Heart Valves: A Call for Mechanistic Studies. Tissue Eng Part B Rev. 2018 Jun; 24: 240-253.
Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15; fj201800458.
Relation T, Yi T, Guess AJ, La Perle K, Otsuru S, Hasgur S, Dominici M, Breuer C, Horwitz EM. Intratumoral Delivery of Interferon?-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Stem Cells. 2018 Jun; 36: 915-924.
Onwuka E, King N, Heuer E, Breuer C. The Heart and Great Vessels. Cold Spring Harb Perspect Med. 2018 Mar 1; 8:
Fukunishi T, Best CA, Ong CS, Groehl T, Reinhardt J, Yi T, Miyachi H, Zhang H, Shinoka T, Breuer CK, Johnson J, Hibino N. Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts. Tissue Eng Part A. 2018 Jan; 24: 135-144.
Best C, Strouse R, Hor K, Pepper V, Tipton A, Kelly J, Shinoka T, Breuer C. Toward a patient-specific tissue engineered vascular graft. J Tissue Eng. 2018 Jan-Dec; 9: 2041731418764709.
Best CA, Pepper VK, Ohst D, Bodnyk K, Heuer E, Onwuka EA, King N, Strouse R, Grischkan J, Breuer CK, Johnson J, Chiang T. Designing a tissue-engineered tracheal scaffold for preclinical evaluation. Int J Pediatr Otorhinolaryngol. 2018 Jan; 104: 155-160.
Maxfield MW, Stacy MR, Kurobe H, Tara S, Yi T, Cleary MA, Zhuang ZW, Rodriguez-Davalos MI, Emre SH, Iwakiri Y, Shinoka T, Breuer CK. Novel application and serial evaluation of tissue-engineered portal vein grafts in a murine model. Regen Med. 2017 Dec; 12: 929-938.
Szafron JM, Breuer CK, Wang Y, Humphrey JD. Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts. J Biomech Eng. 2017 Dec 1; 139:
Pepper VK, Onwuka EA, Best CA, King N, Heuer E, Johnson J, Breuer CK, Grischkan JM, Chiang T. Endoscopic management of tissue-engineered tracheal graft stenosis in an ovine model. Laryngoscope. 2017 Oct; 127: 2219-2224.
Sugiura T, Tara S, Nakayama H, Yi T, Lee YU, Shoji T, Breuer CK, Shinoka T. Fast-degrading bioresorbable arterial vascular graft with high cellular infiltration inhibits calcification of the graft. J Vasc Surg. 2017 Jul; 66: 243-250.
Onwuka E, Best C, Sawyer A, Yi T, Heuer E, Sams M, Wiet M, Zheng H, Kyriakides T, Breuer C. The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft. Regen Med. 2017 Apr; 12: 249-261.
Pepper VK, Clark ES, Best CA, Onwuka EA, Sugiura T, Heuer ED, Moko LE, Miyamoto S, Miyachi H, Berman DP, Cheatham SL, Chisolm JL, Shinoka T, Breuer CK, Cheatham JP. Intravascular Ultrasound Characterization of a Tissue-Engineered Vascular Graft in an Ovine Model. J Cardiovasc Transl Res. 2017 Apr; 10: 128-138.
Sugiura T, Agarwal R, Tara S, Yi T, Lee YU, Breuer CK, Weiss AS, Shinoka T. Tropoelastin inhibits intimal hyperplasia of mouse bioresorbable arterial vascular grafts. Acta Biomater. 2017 Apr 1; 52: 74-80.
Fukunishi T, Best CA, Sugiura T, Opfermann J, Ong CS, Shinoka T, Breuer CK, Krieger A, Johnson J, Hibino N. Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model. J Thorac Cardiovasc Surg. 2017 Apr; 153: 924-932.
Best C, Tara S, Wiet M, Reinhardt J, Pepper V, Ball M, Yi T, Shinoka T, Breuer C. Deconstructing the Tissue Engineered Vascular Graft: Evaluating Scaffold Pre-Wetting, Conditioned Media Incubation, and Determining the Optimal Mononuclear Cell Source. ACS Biomater Sci Eng. 2017; 3: 1972-1979.
View More Publications
Tissue engineered vascular grafts are used to create an extracardiac total cavopulmonary connection, from the inferior vena cava to the right pulmonary artery, during the Fontan procedure. The right atrium is isolated from venous return. Venous blood is passively delivered to the right pulmonary artery.
Zbinden JC, Mirhaidari GJM, Blum KM, Musgrave AJ, Reinhardt JW, Breuer CK, Barker JC. The lysosomal trafficking regulator is necessary for normal wound healing. Wound Repair Regen. 2022 Jan; 30: 82-99.
Liu L, Dharmadhikari S, Pouliot RA, Li MM, Minneci PM, Tan Z, Shontz K, Johnson J, Reynolds SD, Breuer CK, Weiss DJ, Chiang T. Modulation of Synthetic Tracheal Grafts with Extracellular Matrix Coatings. Bioengineering (Basel). 2021 Aug 20; 8:
Schwarz EL, Kelly JM, Blum KM, Hor KN, Yates AR, Zbinden JC, Verma A, Lindsey SE, Ramachandra AB, Szafron JM, Humphrey JD, Shin'oka T, Marsden AL, Breuer CK. Publisher Correction: Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients. NPJ Regen Med. 2021 Aug 12; 6: 47.
Liu Y, Feng X, Liu H, McComb DW, Breuer CK, Sacks MS. On the shape and structure of the murine pulmonary heart valve. Sci Rep. 2021 Jul 7; 11: 14078.
Tan ZH, Dharmadhikari S, Liu L, Wolter G, Shontz KM, Reynolds SD, Johnson J, Breuer CK, Chiang T. Tracheal Macrophages During Regeneration and Repair of Long-Segment Airway Defects. Laryngoscope. 2021 Jun 21;
Matsuzaki Y, Miyamoto S, Miyachi H, Iwaki R, Shoji T, Blum K, Chang YC, Kelly J, Reinhardt JW, Nakayama H, Breuer CK, Shinoka T. Improvement of a Novel Small-diameter Tissue-engineered Arterial Graft With Heparin Conjugation. Ann Thorac Surg. 2021 Apr; 111: 1234-1241.
Chang YC, Mirhaidari G, Kelly J, Breuer C. Current Challenges and Solutions to Tissue Engineering of Large-scale Cardiac Constructs. Curr Cardiol Rep. 2021 Mar 17; 23: 47.
Wu YL, Szafron JM, Blum KM, Zbinden JC, Khosravi R, Best CA, Reinhardt JW, Zeng Q, Yi T, Shinoka T, Humphrey JD, Breuer CK, Wang Y. Electrospun Tissue-Engineered Arterial Graft Thickness Affects Long-Term Composition and Mechanics. Tissue Eng Part A. 2020 Sep 30;
Danielson A, Liu L, Shontz KM, Syed H, Dharmadhikari S, Reynolds SD, Breuer CK, Chiang T. Spatial and Temporal Analysis of Host Cells in Tracheal Graft Implantation. Laryngoscope. 2020 Jun 10;
Agarwal R, Blum KM, Musgrave A, Onwuka EA, Yi T, Reinhardt JW, A Best C, Breuer CK. Degradation and in vivo evaluation of polycaprolactone, poly(e-caprolactone-co-L-lactide), and poly-L-lactic acid as scaffold sealant polymers for murine tissue-engineered vascular grafts. Regen Med. 2019 Jul; 14: 627-637.
Szafron JM, B Ramachandra A, Breuer CK, Marsden AL, Humphrey JD. Optimization of Tissue Engineered Vascular Graft Design Using Computational Modeling. Tissue Eng Part C Methods. 2019 Jun 20;
Best CA, Szafron JM, Rocco KA, Zbinden J, Dean EW, Maxfield MW, Kurobe H, Tara S, Bagi PS, Udelsman BV, Khosravi R, Yi T, Shinoka T, Humphrey JD, Breuer CK. Differential outcomes of venous and arterial tissue engineered vascular grafts highlight the importance of coupling long-term implantation studies with computational modeling. Acta Biomater. 2019 Jun 12;
Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.
Dharmadhikari S, Best CA, King N, Henderson M, Johnson J, Breuer CK, Chiang T. Mouse Model of Tracheal Replacement With Electrospun Nanofiber Scaffolds. Ann Otol Rhinol Laryngol. 2019 May; 128: 391-400.
Pepper V, Best CA, Buckley K, Schwartz C, Onwuka E, King N, White A, Dharmadhikari S, Reynolds SD, Johnson J, Grischkan J, Breuer CK, Chiang T. Factors Influencing Poor Outcomes in Synthetic Tissue-Engineered Tracheal Replacement. Otolaryngol Head Neck Surg. 2019 Apr 30; 194599819844754.
Wiet MG, Dharmadhikari S, White A, Reynolds SD, Johnson J, Breuer CK, Chiang T. Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model. J Vis Exp. 2019 Apr 1;
Smith RJ Jr, Yi T, Nasiri B, Breuer CK, Andreadis ST. Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response. FASEB J. 2019 Apr; 33: 5089-5100.
Francom CR, Best CA, Eaton RG, Pepper V, Onwuka AJ, Breuer CK, Merz Lind MN, Grischkan JM, Chiang T. Clinical validation and reproducibility of endoscopic airway measurement in pediatric aerodigestive evaluation. Int J Pediatr Otorhinolaryngol. 2019 Jan; 116: 65-69.
Miyachi H, Reinhardt JW, Otsuru S, Tara S, Nakayama H, Yi T, Lee YU, Miyamoto S, Shoji T, Sugiura T, Breuer CK, Shinoka T. Bone marrow-derived mononuclear cell seeded bioresorbable vascular graft improves acute graft patency by inhibiting thrombus formation via platelet adhesion. Int J Cardiol. 2018 Sep 1; 266: 61-66.
Stacy MR, Best CA, Maxfield MW, Qiu M, Naito Y, Kurobe H, Mahler N, Rocco KA, Sinusas AJ, Shinoka T, Sampath S, Breuer CK. Magnetic Resonance Imaging of Shear Stress and Wall Thickness in Tissue-Engineered Vascular Grafts. Tissue Eng Part C Methods. 2018 Aug; 24: 465-473.
Eichaker L, Li C, King N, Pepper V, Best C, Onwuka E, Heuer E, Zhao K, Grischkan J, Breuer C, Johnson J, Chiang T. Quantification of tissue-engineered trachea performance with computational fluid dynamics. Laryngoscope. 2018 Aug; 128: E272-E279.
Best C, Fukunishi T, Drews J, Khosravi R, Hor K, Mahler N, Yi T, Humphrey JD, Johnson J, Breuer CK, Hibino N. Oversized Biodegradable Arterial Grafts Promote Enhanced Neointimal Tissue Formation. Tissue Eng Part A. 2018 Aug; 24: 1251-1261.
Blum KM, Drews JD, Breuer CK. Tissue-Engineered Heart Valves: A Call for Mechanistic Studies. Tissue Eng Part B Rev. 2018 Jun; 24: 240-253.
Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15; fj201800458.
Relation T, Yi T, Guess AJ, La Perle K, Otsuru S, Hasgur S, Dominici M, Breuer C, Horwitz EM. Intratumoral Delivery of Interferon?-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Stem Cells. 2018 Jun; 36: 915-924.
Onwuka E, King N, Heuer E, Breuer C. The Heart and Great Vessels. Cold Spring Harb Perspect Med. 2018 Mar 1; 8:
Fukunishi T, Best CA, Ong CS, Groehl T, Reinhardt J, Yi T, Miyachi H, Zhang H, Shinoka T, Breuer CK, Johnson J, Hibino N. Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts. Tissue Eng Part A. 2018 Jan; 24: 135-144.
Best C, Strouse R, Hor K, Pepper V, Tipton A, Kelly J, Shinoka T, Breuer C. Toward a patient-specific tissue engineered vascular graft. J Tissue Eng. 2018 Jan-Dec; 9: 2041731418764709.
Best CA, Pepper VK, Ohst D, Bodnyk K, Heuer E, Onwuka EA, King N, Strouse R, Grischkan J, Breuer CK, Johnson J, Chiang T. Designing a tissue-engineered tracheal scaffold for preclinical evaluation. Int J Pediatr Otorhinolaryngol. 2018 Jan; 104: 155-160.
Maxfield MW, Stacy MR, Kurobe H, Tara S, Yi T, Cleary MA, Zhuang ZW, Rodriguez-Davalos MI, Emre SH, Iwakiri Y, Shinoka T, Breuer CK. Novel application and serial evaluation of tissue-engineered portal vein grafts in a murine model. Regen Med. 2017 Dec; 12: 929-938.
Szafron JM, Breuer CK, Wang Y, Humphrey JD. Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts. J Biomech Eng. 2017 Dec 1; 139:
Pepper VK, Onwuka EA, Best CA, King N, Heuer E, Johnson J, Breuer CK, Grischkan JM, Chiang T. Endoscopic management of tissue-engineered tracheal graft stenosis in an ovine model. Laryngoscope. 2017 Oct; 127: 2219-2224.
Sugiura T, Tara S, Nakayama H, Yi T, Lee YU, Shoji T, Breuer CK, Shinoka T. Fast-degrading bioresorbable arterial vascular graft with high cellular infiltration inhibits calcification of the graft. J Vasc Surg. 2017 Jul; 66: 243-250.
Onwuka E, Best C, Sawyer A, Yi T, Heuer E, Sams M, Wiet M, Zheng H, Kyriakides T, Breuer C. The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft. Regen Med. 2017 Apr; 12: 249-261.
Pepper VK, Clark ES, Best CA, Onwuka EA, Sugiura T, Heuer ED, Moko LE, Miyamoto S, Miyachi H, Berman DP, Cheatham SL, Chisolm JL, Shinoka T, Breuer CK, Cheatham JP. Intravascular Ultrasound Characterization of a Tissue-Engineered Vascular Graft in an Ovine Model. J Cardiovasc Transl Res. 2017 Apr; 10: 128-138.
Sugiura T, Agarwal R, Tara S, Yi T, Lee YU, Breuer CK, Weiss AS, Shinoka T. Tropoelastin inhibits intimal hyperplasia of mouse bioresorbable arterial vascular grafts. Acta Biomater. 2017 Apr 1; 52: 74-80.
Fukunishi T, Best CA, Sugiura T, Opfermann J, Ong CS, Shinoka T, Breuer CK, Krieger A, Johnson J, Hibino N. Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model. J Thorac Cardiovasc Surg. 2017 Apr; 153: 924-932.
Best C, Tara S, Wiet M, Reinhardt J, Pepper V, Ball M, Yi T, Shinoka T, Breuer C. Deconstructing the Tissue Engineered Vascular Graft: Evaluating Scaffold Pre-Wetting, Conditioned Media Incubation, and Determining the Optimal Mononuclear Cell Source. ACS Biomater Sci Eng. 2017; 3: 1972-1979.
View More Publications
- Zbinden JC, Mirhaidari GJM, Blum KM, Musgrave AJ, Reinhardt JW, Breuer CK, Barker JC. The lysosomal trafficking regulator is necessary for normal wound healing. Wound Repair Regen. 2022 Jan; 30: 82-99.
- Liu L, Dharmadhikari S, Pouliot RA, Li MM, Minneci PM, Tan Z, Shontz K, Johnson J, Reynolds SD, Breuer CK, Weiss DJ, Chiang T. Modulation of Synthetic Tracheal Grafts with Extracellular Matrix Coatings. Bioengineering (Basel). 2021 Aug 20; 8:
- Schwarz EL, Kelly JM, Blum KM, Hor KN, Yates AR, Zbinden JC, Verma A, Lindsey SE, Ramachandra AB, Szafron JM, Humphrey JD, Shin’oka T, Marsden AL, Breuer CK. Publisher Correction: Hemodynamic performance of tissue-engineered vascular grafts in Fontan patients. NPJ Regen Med. 2021 Aug 12; 6: 47.
- Liu Y, Feng X, Liu H, McComb DW, Breuer CK, Sacks MS. On the shape and structure of the murine pulmonary heart valve. Sci Rep. 2021 Jul 7; 11: 14078.
- Tan ZH, Dharmadhikari S, Liu L, Wolter G, Shontz KM, Reynolds SD, Johnson J, Breuer CK, Chiang T. Tracheal Macrophages During Regeneration and Repair of Long-Segment Airway Defects. Laryngoscope. 2021 Jun 21;
- Matsuzaki Y, Miyamoto S, Miyachi H, Iwaki R, Shoji T, Blum K, Chang YC, Kelly J, Reinhardt JW, Nakayama H, Breuer CK, Shinoka T. Improvement of a Novel Small-diameter Tissue-engineered Arterial Graft With Heparin Conjugation. Ann Thorac Surg. 2021 Apr; 111: 1234-1241.
- Chang YC, Mirhaidari G, Kelly J, Breuer C. Current Challenges and Solutions to Tissue Engineering of Large-scale Cardiac Constructs. Curr Cardiol Rep. 2021 Mar 17; 23: 47.
- Wu YL, Szafron JM, Blum KM, Zbinden JC, Khosravi R, Best CA, Reinhardt JW, Zeng Q, Yi T, Shinoka T, Humphrey JD, Breuer CK, Wang Y. Electrospun Tissue-Engineered Arterial Graft Thickness Affects Long-Term Composition and Mechanics. Tissue Eng Part A. 2020 Sep 30;
- Danielson A, Liu L, Shontz KM, Syed H, Dharmadhikari S, Reynolds SD, Breuer CK, Chiang T. Spatial and Temporal Analysis of Host Cells in Tracheal Graft Implantation. Laryngoscope. 2020 Jun 10;
- Agarwal R, Blum KM, Musgrave A, Onwuka EA, Yi T, Reinhardt JW, A Best C, Breuer CK. Degradation and in vivo evaluation of polycaprolactone, poly(e-caprolactone-co-L-lactide), and poly-L-lactic acid as scaffold sealant polymers for murine tissue-engineered vascular grafts. Regen Med. 2019 Jul; 14: 627-637.
- Szafron JM, B Ramachandra A, Breuer CK, Marsden AL, Humphrey JD. Optimization of Tissue Engineered Vascular Graft Design Using Computational Modeling. Tissue Eng Part C Methods. 2019 Jun 20;
- Best CA, Szafron JM, Rocco KA, Zbinden J, Dean EW, Maxfield MW, Kurobe H, Tara S, Bagi PS, Udelsman BV, Khosravi R, Yi T, Shinoka T, Humphrey JD, Breuer CK. Differential outcomes of venous and arterial tissue engineered vascular grafts highlight the importance of coupling long-term implantation studies with computational modeling. Acta Biomater. 2019 Jun 12;
- Reinhardt JW, Rosado JDR, Barker JC, Lee YU, Best CA, Yi T, Zeng Q, Partida-Sanchez S, Shinoka T, Breuer CK. Early natural history of neotissue formation in tissue-engineered vascular grafts in a murine model. Regen Med. 2019 May; 14: 389-408.
- Dharmadhikari S, Best CA, King N, Henderson M, Johnson J, Breuer CK, Chiang T. Mouse Model of Tracheal Replacement With Electrospun Nanofiber Scaffolds. Ann Otol Rhinol Laryngol. 2019 May; 128: 391-400.
- Pepper V, Best CA, Buckley K, Schwartz C, Onwuka E, King N, White A, Dharmadhikari S, Reynolds SD, Johnson J, Grischkan J, Breuer CK, Chiang T. Factors Influencing Poor Outcomes in Synthetic Tissue-Engineered Tracheal Replacement. Otolaryngol Head Neck Surg. 2019 Apr 30; 194599819844754.
- Wiet MG, Dharmadhikari S, White A, Reynolds SD, Johnson J, Breuer CK, Chiang T. Seeding and Implantation of a Biosynthetic Tissue-engineered Tracheal Graft in a Mouse Model. J Vis Exp. 2019 Apr 1;
- Smith RJ Jr, Yi T, Nasiri B, Breuer CK, Andreadis ST. Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response. FASEB J. 2019 Apr; 33: 5089-5100.
- Francom CR, Best CA, Eaton RG, Pepper V, Onwuka AJ, Breuer CK, Merz Lind MN, Grischkan JM, Chiang T. Clinical validation and reproducibility of endoscopic airway measurement in pediatric aerodigestive evaluation. Int J Pediatr Otorhinolaryngol. 2019 Jan; 116: 65-69.
- Miyachi H, Reinhardt JW, Otsuru S, Tara S, Nakayama H, Yi T, Lee YU, Miyamoto S, Shoji T, Sugiura T, Breuer CK, Shinoka T. Bone marrow-derived mononuclear cell seeded bioresorbable vascular graft improves acute graft patency by inhibiting thrombus formation via platelet adhesion. Int J Cardiol. 2018 Sep 1; 266: 61-66.
- Stacy MR, Best CA, Maxfield MW, Qiu M, Naito Y, Kurobe H, Mahler N, Rocco KA, Sinusas AJ, Shinoka T, Sampath S, Breuer CK. Magnetic Resonance Imaging of Shear Stress and Wall Thickness in Tissue-Engineered Vascular Grafts. Tissue Eng Part C Methods. 2018 Aug; 24: 465-473.
- Eichaker L, Li C, King N, Pepper V, Best C, Onwuka E, Heuer E, Zhao K, Grischkan J, Breuer C, Johnson J, Chiang T. Quantification of tissue-engineered trachea performance with computational fluid dynamics. Laryngoscope. 2018 Aug; 128: E272-E279.
- Best C, Fukunishi T, Drews J, Khosravi R, Hor K, Mahler N, Yi T, Humphrey JD, Johnson J, Breuer CK, Hibino N. Oversized Biodegradable Arterial Grafts Promote Enhanced Neointimal Tissue Formation. Tissue Eng Part A. 2018 Aug; 24: 1251-1261.
- Blum KM, Drews JD, Breuer CK. Tissue-Engineered Heart Valves: A Call for Mechanistic Studies. Tissue Eng Part B Rev. 2018 Jun; 24: 240-253.
- Ruiz-Rosado JD, Lee YU, Mahler N, Yi T, Robledo-Avila F, Martinez-Saucedo D, Lee AY, Shoji T, Heuer E, Yates AR, Pober JS, Shinoka T, Partida-Sanchez S, Breuer CK. Angiotensin II receptor I blockade prevents stenosis of tissue engineered vascular grafts. FASEB J. 2018 Jun 15; fj201800458.
- Relation T, Yi T, Guess AJ, La Perle K, Otsuru S, Hasgur S, Dominici M, Breuer C, Horwitz EM. Intratumoral Delivery of Interferon?-Secreting Mesenchymal Stromal Cells Repolarizes Tumor-Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo. Stem Cells. 2018 Jun; 36: 915-924.
- Onwuka E, King N, Heuer E, Breuer C. The Heart and Great Vessels. Cold Spring Harb Perspect Med. 2018 Mar 1; 8:
- Fukunishi T, Best CA, Ong CS, Groehl T, Reinhardt J, Yi T, Miyachi H, Zhang H, Shinoka T, Breuer CK, Johnson J, Hibino N. Role of Bone Marrow Mononuclear Cell Seeding for Nanofiber Vascular Grafts. Tissue Eng Part A. 2018 Jan; 24: 135-144.
- Best C, Strouse R, Hor K, Pepper V, Tipton A, Kelly J, Shinoka T, Breuer C. Toward a patient-specific tissue engineered vascular graft. J Tissue Eng. 2018 Jan-Dec; 9: 2041731418764709.
- Best CA, Pepper VK, Ohst D, Bodnyk K, Heuer E, Onwuka EA, King N, Strouse R, Grischkan J, Breuer CK, Johnson J, Chiang T. Designing a tissue-engineered tracheal scaffold for preclinical evaluation. Int J Pediatr Otorhinolaryngol. 2018 Jan; 104: 155-160.
- Maxfield MW, Stacy MR, Kurobe H, Tara S, Yi T, Cleary MA, Zhuang ZW, Rodriguez-Davalos MI, Emre SH, Iwakiri Y, Shinoka T, Breuer CK. Novel application and serial evaluation of tissue-engineered portal vein grafts in a murine model. Regen Med. 2017 Dec; 12: 929-938.
- Szafron JM, Breuer CK, Wang Y, Humphrey JD. Stress Analysis-Driven Design of Bilayered Scaffolds for Tissue-Engineered Vascular Grafts. J Biomech Eng. 2017 Dec 1; 139:
- Pepper VK, Onwuka EA, Best CA, King N, Heuer E, Johnson J, Breuer CK, Grischkan JM, Chiang T. Endoscopic management of tissue-engineered tracheal graft stenosis in an ovine model. Laryngoscope. 2017 Oct; 127: 2219-2224.
- Sugiura T, Tara S, Nakayama H, Yi T, Lee YU, Shoji T, Breuer CK, Shinoka T. Fast-degrading bioresorbable arterial vascular graft with high cellular infiltration inhibits calcification of the graft. J Vasc Surg. 2017 Jul; 66: 243-250.
- Onwuka E, Best C, Sawyer A, Yi T, Heuer E, Sams M, Wiet M, Zheng H, Kyriakides T, Breuer C. The role of myeloid cell-derived PDGF-B in neotissue formation in a tissue-engineered vascular graft. Regen Med. 2017 Apr; 12: 249-261.
- Pepper VK, Clark ES, Best CA, Onwuka EA, Sugiura T, Heuer ED, Moko LE, Miyamoto S, Miyachi H, Berman DP, Cheatham SL, Chisolm JL, Shinoka T, Breuer CK, Cheatham JP. Intravascular Ultrasound Characterization of a Tissue-Engineered Vascular Graft in an Ovine Model. J Cardiovasc Transl Res. 2017 Apr; 10: 128-138.
- Sugiura T, Agarwal R, Tara S, Yi T, Lee YU, Breuer CK, Weiss AS, Shinoka T. Tropoelastin inhibits intimal hyperplasia of mouse bioresorbable arterial vascular grafts. Acta Biomater. 2017 Apr 1; 52: 74-80.
- Fukunishi T, Best CA, Sugiura T, Opfermann J, Ong CS, Shinoka T, Breuer CK, Krieger A, Johnson J, Hibino N. Preclinical study of patient-specific cell-free nanofiber tissue-engineered vascular grafts using 3-dimensional printing in a sheep model. J Thorac Cardiovasc Surg. 2017 Apr; 153: 924-932.
- Best C, Tara S, Wiet M, Reinhardt J, Pepper V, Ball M, Yi T, Shinoka T, Breuer C. Deconstructing the Tissue Engineered Vascular Graft: Evaluating Scaffold Pre-Wetting, Conditioned Media Incubation, and Determining the Optimal Mononuclear Cell Source. ACS Biomater Sci Eng. 2017; 3: 1972-1979.
Education
Date of Appointment at Nationwide Children’s Hospital: 09/28/2012
Board Certifications
Pediatric Surgery
Fellowship
Hasbro Children’s Hospital
Date Completed: 06/30/1999
Fellowship
Harvard Medical School
Date Completed: 06/30/1995
Residency
Rhode Island Hospital
Date Completed: 06/30/1997
Residency
Boston Children’s Hospital
Date Completed: 06/30/1993
Residency
Rhode Island Hospital
Date Completed: 06/30/1992
Medical School
Warren Alpert Medical School of Brown University
Date Completed: 05/28/1990
Education
Date of Appointment at Nationwide Children’s Hospital: 09/28/2012
Board Certifications
Pediatric Surgery
Fellowship
Hasbro Children’s Hospital
Date Completed: 06/30/1999
Fellowship
Harvard Medical School
Date Completed: 06/30/1995
Residency
Rhode Island Hospital
Date Completed: 06/30/1997
Residency
Boston Children’s Hospital
Date Completed: 06/30/1993
Residency
Rhode Island Hospital
Date Completed: 06/30/1992
Medical School
Warren Alpert Medical School of Brown University
Date Completed: 05/28/1990
Education
Date of Appointment at Nationwide Children’s Hospital: 09/28/2012
Board Certifications
Pediatric Surgery
Fellowship
Hasbro Children’s Hospital
Date Completed: 06/30/1999
Fellowship
Harvard Medical School
Date Completed: 06/30/1995
Residency
Rhode Island Hospital
Date Completed: 06/30/1997
Residency
Boston Children’s Hospital
Date Completed: 06/30/1993
Residency
Rhode Island Hospital
Date Completed: 06/30/1992
Medical School
Warren Alpert Medical School of Brown University
Date Completed: 05/28/1990
Date of Appointment at Nationwide Children’s Hospital: 09/28/2012
Board Certifications
Pediatric Surgery
Fellowship
Hasbro Children’s Hospital
Date Completed: 06/30/1999
Fellowship
Harvard Medical School
Date Completed: 06/30/1995
Residency
Rhode Island Hospital
Date Completed: 06/30/1997
Residency
Boston Children’s Hospital
Date Completed: 06/30/1993
Residency
Rhode Island Hospital
Date Completed: 06/30/1992
Medical School
Warren Alpert Medical School of Brown University
Date Completed: 05/28/1990
Date of Appointment at Nationwide Children’s Hospital: 09/28/2012
Board Certifications
Pediatric Surgery
Fellowship
Hasbro Children’s Hospital
Date Completed: 06/30/1999
Fellowship
Harvard Medical School
Date Completed: 06/30/1995
Residency
Rhode Island Hospital
Date Completed: 06/30/1997
Residency
Boston Children’s Hospital
Date Completed: 06/30/1993
Residency
Rhode Island Hospital
Date Completed: 06/30/1992
Medical School
Warren Alpert Medical School of Brown University
Date Completed: 05/28/1990
- Pediatric Surgery
Contact Information
General Pediatric Surgery
Call us at: (614) 722-3900
Fax us at: (614) 722-3903
Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)
Contact Information
General Pediatric Surgery
Call us at: (614) 722-3900
Fax us at: (614) 722-3903
Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)
Contact Information
General Pediatric Surgery
Call us at: (614) 722-3900
Fax us at: (614) 722-3903
Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)
General Pediatric Surgery
Call us at: (614) 722-3900
Fax us at: (614) 722-3903
Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)
Call us at: (614) 722-3900
Fax us at: (614) 722-3903
Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)
Call us at: (614) 722-3900
Fax us at: (614) 722-3903
Pediatric Surgery700 Children's DrColumbus, OH 43205 (map)
- Call us at:
- (614) 722-3900
- Fax us at:
- (614) 722-3903
- Pediatric Surgery700 Children’s DrColumbus, OH 43205 (map)
