Carlo Di Lorenzo

Contact Information

Call us at: (614) 722-3450

Fax us at: (614) 722-3454

PediatricsGastroenterology & Hepatology & Nutrition700 Children’s DrColumbus, OH 43205 (map)

Learn more about Carlo Di Lorenzo

Biography

Carlo Di Lorenzo, MD, is Chief of the Division of Pediatric Gastroenterology, Hepatology and Nutrition at Nationwide Children’s Hospital where he holds the Robert F. and Edgar T. Wolfe Foundation Endowed Chair in Pediatric Gastroenterology and Professor of Clinical Pediatrics at The Ohio State University College of Medicine. Dr. Di Lorenzo has been among the first clinical investigators to assess the diagnostic value of antroduodenal and colonic manometry and to use the electronic barostat to assess visceral sensitivity in children. He co-authored the only three books on pediatric gastrointestinal motility, and has published more than 300 peer-reviewed original articles, chapters, invited reviews and editorials. He has been awarded the Master Award in Gastroenterology for Basic or Clinical research in Gastroenterology by the AGAI, the Golden Stethoscope Award by Nationwide Children’s Hospital and the Award for Senior Investigator in Pediatrics by the IFFGD. He has been President of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Named multiple times among the “Best Doctors in America," Dr. Di Lorenzo has served on the editorial board of the Journal of Pediatric Gastroenterology, Hepatology and Nutrition and the Journal of Neurogastroenterology and Motility. He has functioned as a grant reviewer for the National Institutes of Health and abstract reviewer for the American Gastroenterological Association (AGA). Dr. Di Lorenzo has also held prominent roles in numerous national and international organizations and work groups, including:

Chair of the American Academy of Pediatrics (AAP) subcommittee to develop evaluation and treatment guidelines for functional abdominal pain Chair of the Functional Gastrointestinal Disorders and Neurogastroenterology working group of the second World Congress of Pediatric Gastroenterology Chair of the American Neurogastroenterology and Motility Society (ANMS) committee for the development of minimal standards for motility testing in children Chair of the Adolescent Committee of the Rome III and Rome IV criteria Chair of the Growth, Development and Child Health Section of the American Gastroenterology Association

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English French Italian

Academic and Clinical Areas

Gastroenterology, Hepatology & Nutrition

Division Chief

Motility

Director

Center for Colorectal and Pelvic Reconstruction

Physician Team

Rumination Syndrome Program

Director

Gastroenterology Motility Fellowship

Faculty

Pediatric Colorectal Research Fellowship

Faculty

Gastroenterology Fellowship

Faculty

Pediatric Colorectal Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Gastroenterology & Hepatology & Nutrition

Awards, Honors & Organizations

Golden Stethoscope Award Recipient, Nationwide Children’s Hospital, 2012 Listed, Best Doctors in America Board Member, United Mitochondrial Disease Foundation Chairman, Pediatric Slide Committee for the Rome III Initiative Council Member, Functional Bowel Group (FBG) Grant Reviewer, Thrasher Research Fund Member, Board for the “Small Intestine” section Faculty of 1000 Medicine Member, Clinical Practice Committee of the American Motility Society Member, Editorial Boards of Journal of Pediatric Gastroenterology and Nutrition and Journal of Neurogastroenterology and Motility Member, Functional GI Disorders & Motility Disorders Working Group of the National Commission on Digestive Diseases (NCDD) of the NIH Member, GI Working Group for “America’s Best Children’s Hospitals” for U.S. News & World Report Member, Scientific Advisory Board (SAB) of the Children’s Digestive Health and Nutrition Foundation (CDHNF) Member, Scientific Advisory Board of the University of North Carolina (UNC) Center for Functional GI and Motility Disorders Member, Sub-board of Pediatric Gastroenterology of the American Board of Pediatrics (ABP)

Research

Publications

                  Hawa K, Janse S, Lee J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Providing a Constipation Action Plan to Families of Children With Constipation Decreases Health Care Utilization. J Pediatr Gastroenterol Nutr. 2022 Nov 1; 75: 589-594.

                


                  Hawa K, Lu PL, Holzmacher M, Wall J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Van Diest AK. INTENSIVE OUTPATIENT TREATMENT OF PEDIATRIC RUMINATION SYNDROME IN THE ERA OF TELEMEDICINE. J Pediatr Gastroenterol Nutr. 2022 Jul 28;  

                


                  Baaleman DF, Hallagan A, Halleran DR, Orsagh-Yentis DK, Levitt MA, Wood RJ, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. Anal Botulinum Toxin in Children with Hirschsprung Disease and Functional Constipation: A Prospective Cohort study. Eur J Pediatr Surg. 2022 Jul 19;  

                


                  Baaleman DF, Vriesman MH, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL, Koppen IJN. Do we need an extra dimension? A pilot study on the use of three-dimensional anorectal manometry in children with functional constipation. Neurogastroenterol Motil. 2022 Apr 4;  e14370.

                


                  Baaleman DF, Vriesman MH, Koppen IJN, Osborne KM, Benninga MA, Saps M, Yacob D, Lu PL, Woodley FW, Lorenzo CD. Hypnosis to Reduce Distress in Children Undergoing Anorectal Manometry: A Randomized Controlled Pilot Trial. J Neurogastroenterol Motil. 2022 Apr 30; 28: 312-319.

                


                  Di Lorenzo C. Functional Nausea Is Real and Makes You Sick. Front Pediatr. 2022; 10: 848659.

                


                  Nurko S, Saps M, Kossovsky J, Zion SR, Di Lorenzo C, Vaz K, Hawthorne K, Wu R, Ciciora S, Rosen JM, Kaptchuk TJ, Kelley JM. Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial. JAMA Pediatr. 2022 Jan 31;  

                


                  Strisciuglio C, Martinelli M, Lu P, Bar Lev MR, Beinvogl B, Benninga MA, Di Lorenzo C, Fiori Nastro F, Nurko S, Pearlstein H, Rosen R, Shamir R, Staiano A. Overall Impact of Coronavirus Disease 2019 Outbreak in Children With Functional Abdominal Pain Disorders: Results From the First Pandemic Phase. J Pediatr Gastroenterol Nutr. 2021 Dec 1; 73: 689-694.

                


                  Ahmad H, Levitt MA, Yacob D, Halleran DR, Gasior AC, Di Lorenzo C, Wood RJ, Langer JC. Evaluation and Management of Persistent Problems After Surgery for Hirschsprung Disease in a Child. Curr Gastroenterol Rep. 2021 Oct 11; 23: 18.

                


                  Orsagh-Yentis DK, Ryan K, Hurwitz N, Diefenbach KA, Teich S, Mousa H, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Gastric electrical stimulation improves symptoms and need for supplemental nutrition in children with severe nausea and vomiting: A ten-year experience. Neurogastroenterol Motil. 2021 Sep; 33: e14199.

                


                  Saps M, Nurko S, Benninga MA, Di Lorenzo C, Garza JM, Thapar N, Richards K, Lee JJ, Altepeter T. A Collaborative Effort to Advance Drug Development in Pediatric Constipation and Irritable Bowel Syndrome. J Pediatr Gastroenterol Nutr. 2021 Aug 1; 73: 145-149.

                


                  Madani S, Madani R, Parikh S, Manivannan A, Orellana WR, Thomas R, Di Lorenzo C. Symptomatic Treatment of Pain-Related Pediatric Functional Gastrointestinal Disorders in a Biopsychosocial Construct, and a Validity Study of Rome III Criteria. Clin Pediatr (Phila). 2021 Jun; 60: 304-313.

                


                  Baaleman DF, Gupta S, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The Use of Linaclotide in Children with Functional Constipation or Irritable Bowel Syndrome: A Retrospective Chart Review. Paediatr Drugs. 2021 May; 23: 307-314.

                


                  Abdulkader ZM, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Predictors of Hospital Admission for Pediatric Cyclic Vomiting Syndrome. J Pediatr. 2021 May; 232: 154-158.

                


                  Benninga MA, Hussain SZ, Sood MR, Nurko S, Hyman P, Clifford RA, O'Gorman M, Losch-Beridon T, Mareya S, Lichtlen P, Di Lorenzo C. Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-Blind Study With Long-term Extension. Clin Gastroenterol Hepatol. 2021 Apr 7;  

                


                  Seilhamer C, Di Lorenzo C, Holstine J, Samora JB. Creating a bowel management plan for pediatric orthopaedic spine surgery patients. Spine Deform. 2021 Mar; 9: 365-371.

                


                  Elfar W, Gurjar AA, Talukder MAH, Noble M, Di Lorenzo C, Elfar J. Erythropoietin promotes functional recovery in a mouse model of postoperative ileus. Neurogastroenterol Motil. 2021 Feb; 33: e14049.

                


                  Khlevner J, Rosen R, Ambartsumyan L, Lusman SS, Rosen JM, Yacob D, Mousa H, Nurko S, Di Lorenzo C, Boruta M, Ratcliffe EM, Feinstein L, Snyder J, Wood RJ, Graham K, Saps M, Gyawali CP, Rodriguez L, Belkind-Gerson J. Development of Entrustable Professional Activities and Standards in Training in Pediatric Neurogastroenterology and Motility: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and American Neurogastroenterology and Motility Society Position Paper. J Pediatr Gastroenterol Nutr. 2021 Jan 1; 72: 168-180.

                


                  Yacob D, Kroon Van Diest AM, Di Lorenzo C. Functional abdominal pain in adolescents: case-based management. Frontline Gastroenterol. 2021; 12: 629-635.

                


                  Baaleman DF, Malamisura M, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The not-so-rare absent RAIR: Internal anal sphincter achalasia in a review of 1072 children with constipation undergoing high-resolution anorectal manometry. Neurogastroenterol Motil. 2020 Dec 10;  e14028.

                


                  Jadcherla SR, Hasenstab KA, Wei L, Osborn EK, Viswanathan S, Gulati IK, Slaughter JL, Di Lorenzo C. Role of feeding strategy bundle with acid-suppressive therapy in infants with esophageal acid reflux exposure: a randomized controlled trial. Pediatr Res. 2020 May 7;  

                


                  Jadcherla SR, Sultana Z, Hasenstab-Kenney KA, Prabhakar V, Gulati IK, Di Lorenzo C. Differentiating esophageal sensitivity phenotypes using pH-impedance in intensive care unit infants referred for gastroesophageal reflux symptoms. Pediatr Res. 2020 May 6;  

                


                  Di Lorenzo C. Gastroparesis in children: Paralysis for the child or the provider? Neurogastroenterol Motil. 2020 Mar; 32: e13792.

                


                  Chumpitazi BP, Lewis J, Cooper D, D'Amato M, Lim J, Gupta S, Miranda A, Terry N, Mehta D, Scheimann A, O'Gorman M, Tipnis N, Davies Y, Friedlander J, Smith H, Punati J, Khlevner J, Setty M, Di Lorenzo C. Hypomorphic SI genetic variants are associated with childhood chronic loose stools. PLoS One. 2020; 15: e0231891.

                


                  Halleran DR, Lu PL, Ahmad H, Paradiso MM, Lehmkuhl H, Akers A, Hallagan A, Bali N, Vaz K, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. Anal sphincter botulinum toxin injection in children with functional anorectal and colonic disorders: A large institutional study and review of the literature focusing on complications. J Pediatr Surg. 2019 Nov; 54: 2305-2310.

                


                  Corsetti M, Costa M, Bassotti G, Bharucha AE, Borrelli O, Dinning P, Di Lorenzo C, Huizinga JD, Jimenez M, Rao S, Spiller R, Spencer NJ, Lentle R, Pannemans J, Thys A, Benninga M, Tack J. First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nat Rev Gastroenterol Hepatol. 2019 Jul 11;  

                


                  Di Lorenzo C, Nurko S. It's Ok to be Negative! J Pediatr Gastroenterol Nutr. 2019 Jun 17;  

                


                  Murray HB, Juarascio AS, Di Lorenzo C, Drossman DA, Thomas JJ. Diagnosis and Treatment of Rumination Syndrome: A Critical Review. Am J Gastroenterol. 2019 Apr; 114: 562-578.

                


                  Vilanova-Sanchez A, Halleran DR, Reck-Burneo CA, Gasior AC, Weaver L, Fisher M, Wagner A, Nash O, Booth K, Peters K, Williams C, Brown SM, Lu P, Fuchs M, Diefenbach K, Leonard JR, Hewitt G, McCracken K, Di Lorenzo C, Wood RJ, Levitt MA. A descriptive model for a multidisciplinary unit for colorectal and pelvic malformations. J Pediatr Surg. 2019 Mar; 54: 479-485.

                


                  Di Lorenzo C. 2018 Harry Shwachman Award. J Pediatr Gastroenterol Nutr. 2019 Mar; 68: 291.

                


                  Halleran DR, Vilanova-Sanchez A, Rentea RM, Vriesman MH, Maloof T, Lu PL, Onwuka A, Weaver L, Vaz KK, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. A comparison of Malone appendicostomy and cecostomy for antegrade access as adjuncts to a bowel management program for patients with functional constipation or fecal incontinence. J Pediatr Surg. 2019 Jan; 54: 123-128.

                


                  Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ. Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference. Gastroenterology. 2018 Sep 6;  

                


                  Gasior A, Reck C, Vilanova-Sanchez A, Diefenbach KA, Yacob D, Lu P, Vaz K, Di Lorenzo C, Levitt MA, Wood RJ. Surgical management of functional constipation: An intermediate report of a new approach using a laparoscopic sigmoid resection combined with malone appendicostomy. J Pediatr Surg. 2018 Jun; 53: 1160-1162.

                


                  Thapar N, Saliakellis E, Benninga MA, Borrelli O, Curry J, Faure C, De Giorgio R, Gupte G, Knowles CH, Staiano A, Vandenplas Y, Di Lorenzo C. Paediatric Intestinal Pseudo-obstruction: Evidence and Consensus-based Recommendations From an ESPGHAN-Led Expert Group. J Pediatr Gastroenterol Nutr. 2018 Jun; 66: 991-1019.

                


                  Saps M, Lavigne JV, van Tilburg MA, Miranda A, Benninga MA, Taminiau JA, Di Lorenzo C. Endpoints, reliability, and meaningful changes in clinical trials for children with irritable bowel syndrome. The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 May; 30: e13308.

                


                  Koppen IJN, Vriesman MH, Tabbers MM, Di Lorenzo C, Benninga MA. Awareness and Implementation of the 2014 ESPGHAN/NASPGHAN Guideline for Childhood Functional Constipation. J Pediatr Gastroenterol Nutr. 2018 May; 66: 732-737.

                


                  Di Lorenzo C. 2017 NASPGHAN Distinguished Service Award. J Pediatr Gastroenterol Nutr. 2018 May; 66: 713-714.

                


                  Koppen IJN, Vriesman MH, Saps M, Rajindrajith S, Shi X, van Etten-Jamaludin FS, Di Lorenzo C, Benninga MA, Tabbers MM. Prevalence of Functional Defecation Disorders in Children: A Systematic Review and Meta-Analysis. J Pediatr. 2018 Apr 12;  

                


                  Koppen IJN, Saps M, Lavigne JV, Nurko S, Taminiau JAJM, Di Lorenzo C, Benninga MA. Recommendations for pharmacological clinical trials in children with functional constipation: The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 Apr; 30: e13294.

                


                  Williams KC, Rogers LK, Hill I, Barnard J, Di Lorenzo C. PEG 3350 Administration Is Not Associated with Sustained Elevation of Glycol Levels. J Pediatr. 2018 Apr; 195: 148-153.e1.

                


                  Robin SG, Keller C, Zwiener R, Hyman PE, Nurko S, Saps M, Di Lorenzo C, Shulman RJ, Hyams JS, Palsson O, van Tilburg MAL. Prevalence of Pediatric Functional Gastrointestinal Disorders Utilizing the Rome IV Criteria. J Pediatr. 2018 Apr; 195: 134-139.

                


                  Manini ML, Camilleri M, Grothe R, Di Lorenzo C. Application of Pyridostigmine in Pediatric Gastrointestinal Motility Disorders: A Case Series. Paediatr Drugs. 2018 Apr; 20: 173-180.

                


                  Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, Gupta S, Langendam M, Staiano A, Thapar N, Tipnis N, Tabbers M. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2018 Mar; 66: 516-554.

                


                  Chang L, Di Lorenzo C, Farrugia G, Hamilton FA, Mawe GM, Pasricha PJ, Wiley JW. Functional Bowel Disorders: A Roadmap to Guide the Next Generation of Research. Gastroenterology. 2018 Feb; 154: 723-735.

                


                  Lu PL, Koppen IJN, Orsagh-Yentis DK, Leonhart K, Ambeba EJ, Deans KJ, Minneci PC, Teich S, Diefenbach KA, Alpert SA, Benninga MA, Yacob D, Di Lorenzo C. Sacral nerve stimulation for constipation and fecal incontinence in children: Long-term outcomes, patient benefit, and parent satisfaction. Neurogastroenterol Motil. 2018 Feb; 30: 

                


                  Kuizenga-Wessel S, Koppen IJN, Vriesman MH, Di Lorenzo C, van Dijk M, Beelen MLR, Groeneweg M, Stoffelsen RJ, Benninga MA. Attention Deficit Hyperactivity Disorder and Functional Defecation Disorders in Children. J Pediatr Gastroenterol Nutr. 2018 Feb; 66: 244-249.

                


                  Alioto A, Di Lorenzo C. Long-term Follow-up of Adolescents Treated for Rumination Syndrome in an Inpatient Setting. J Pediatr Gastroenterol Nutr. 2018 Jan; 66: 21-25.

                


                  Vriesman MH, Velasco-Benitez CA, Ramirez CR, Benninga MA, Di Lorenzo C, Saps M. Assessing Children's Report of Stool Consistency: Agreement Between the Pediatric Rome III Questionnaire and the Bristol Stool Scale. J Pediatr. 2017 Nov; 190: 69-73.

                


                  Koppen IJN, Thompson BP, Ambeba EJ, Lane VA, Bates DG, Minneci PC, Deans KJ, Levitt MA, Wood RJ, Benninga MA, Di Lorenzo C, Yacob D. Segmental colonic dilation is associated with premature termination of high-amplitude propagating contractions in children with intractable functional constipation. Neurogastroenterol Motil. 2017 Oct; 29: 1-9.

                


                  Woodley FW, Moore-Clingenpeel M, Machado RS, Nemastil CJ, Jadcherla SR, Hayes D Jr, Kopp BT, Kaul A, Di Lorenzo C, Mousa H. Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux. Pediatr Gastroenterol Hepatol Nutr. 2017 Sep; 20: 153-159.

                


                  Alioto A, Di Lorenzo C, Montgomery ML, Yacob D. High Cost and Low Yield: The Diagnostic Evaluation of Rumination Syndrome in Pediatrics. J Pediatr. 2017 Jun; 185: 155-159.

                


                  Kuizenga-Wessel S, Koppen IJN, Zwager LW, Di Lorenzo C, de Jong JR, Benninga MA. Surgical management of children with intractable functional constipation; experience of a single tertiary children's hospital. Neurogastroenterol Motil. 2017 May; 29: 

                


                  Lu PL, Asti L, Lodwick DL, Nacion KM, Deans KJ, Minneci PC, Teich S, Alpert SA, Yacob D, Di Lorenzo C, Mousa HM. Sacral nerve stimulation allows for decreased antegrade continence enema use in children with severe constipation. J Pediatr Surg. 2017 Apr; 52: 558-562.

                


                  Vandenplas Y, Szajewska H, Benninga M, Di Lorenzo C, Dupont C, Faure C, Miqdadi M, Osatakul S, Ribes-Konickx C, Saps M, Shamir R, Staiano A, BITSS Study Group.. Development of the Brussels Infant and Toddler Stool Scale ('BITSS'): protocol of the study. BMJ Open. 2017 Mar 29; 7: e014620.

                


                  Koppen IJ, Yacob D, Di Lorenzo C, Saps M, Benninga MA, Cooper JN, Minneci PC, Deans KJ, Bates DG, Thompson BP. Assessing colonic anatomy normal values based on air contrast enemas in children younger than 6 years. Pediatr Radiol. 2017 Mar; 47: 306-312.

                


                  Peeters B, Vriesman MH, Koppen IJN, van Dijk M, Grootenhuis MA, Di Lorenzo C, Benninga MA. Parental characteristics and functional constipation in children: a cross-sectional cohort study. BMJ Paediatr Open. 2017; 1: e000100.

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Education

Date of Appointment at Nationwide Children’s Hospital: 08/27/2004

Board Certifications

Pediatric Gastroenterology

Fellowship

Harbor UCLA Medical Center

Date Completed: 06/30/1990

Fellowship

University of Southern California County Hospital

Date Completed: 04/30/1988

Fellowship

Hospital Universitaire des Enfants - Brussels

Date Completed: 12/31/1986

Residency

2nd University of Naples - Italy

Date Completed: 07/31/1988

Internship

2nd University of Naples - Italy

Date Completed: 07/31/1986

Medical School

2nd University of Naples - Italy

Date Completed: 07/31/1984

Contact Information

Pediatrics

Call us at: (614) 722-3450

Fax us at: (614) 722-3454

                    Gastroenterology & Hepatology & Nutrition700 Children's DrColumbus, OH 43205 (map)

Connect with Carlo Di Lorenzo

Connect on Twitter

Contact Information

Call us at: (614) 722-3450

Fax us at: (614) 722-3454

PediatricsGastroenterology & Hepatology & Nutrition700 Children’s DrColumbus, OH 43205 (map)

Learn more about Carlo Di Lorenzo

Biography

Carlo Di Lorenzo, MD, is Chief of the Division of Pediatric Gastroenterology, Hepatology and Nutrition at Nationwide Children’s Hospital where he holds the Robert F. and Edgar T. Wolfe Foundation Endowed Chair in Pediatric Gastroenterology and Professor of Clinical Pediatrics at The Ohio State University College of Medicine. Dr. Di Lorenzo has been among the first clinical investigators to assess the diagnostic value of antroduodenal and colonic manometry and to use the electronic barostat to assess visceral sensitivity in children. He co-authored the only three books on pediatric gastrointestinal motility, and has published more than 300 peer-reviewed original articles, chapters, invited reviews and editorials. He has been awarded the Master Award in Gastroenterology for Basic or Clinical research in Gastroenterology by the AGAI, the Golden Stethoscope Award by Nationwide Children’s Hospital and the Award for Senior Investigator in Pediatrics by the IFFGD. He has been President of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Named multiple times among the “Best Doctors in America," Dr. Di Lorenzo has served on the editorial board of the Journal of Pediatric Gastroenterology, Hepatology and Nutrition and the Journal of Neurogastroenterology and Motility. He has functioned as a grant reviewer for the National Institutes of Health and abstract reviewer for the American Gastroenterological Association (AGA). Dr. Di Lorenzo has also held prominent roles in numerous national and international organizations and work groups, including:

Chair of the American Academy of Pediatrics (AAP) subcommittee to develop evaluation and treatment guidelines for functional abdominal pain Chair of the Functional Gastrointestinal Disorders and Neurogastroenterology working group of the second World Congress of Pediatric Gastroenterology Chair of the American Neurogastroenterology and Motility Society (ANMS) committee for the development of minimal standards for motility testing in children Chair of the Adolescent Committee of the Rome III and Rome IV criteria Chair of the Growth, Development and Child Health Section of the American Gastroenterology Association

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English French Italian

Academic and Clinical Areas

Gastroenterology, Hepatology & Nutrition

Division Chief

Motility

Director

Center for Colorectal and Pelvic Reconstruction

Physician Team

Rumination Syndrome Program

Director

Gastroenterology Motility Fellowship

Faculty

Pediatric Colorectal Research Fellowship

Faculty

Gastroenterology Fellowship

Faculty

Pediatric Colorectal Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Gastroenterology & Hepatology & Nutrition

Awards, Honors & Organizations

Golden Stethoscope Award Recipient, Nationwide Children’s Hospital, 2012 Listed, Best Doctors in America Board Member, United Mitochondrial Disease Foundation Chairman, Pediatric Slide Committee for the Rome III Initiative Council Member, Functional Bowel Group (FBG) Grant Reviewer, Thrasher Research Fund Member, Board for the “Small Intestine” section Faculty of 1000 Medicine Member, Clinical Practice Committee of the American Motility Society Member, Editorial Boards of Journal of Pediatric Gastroenterology and Nutrition and Journal of Neurogastroenterology and Motility Member, Functional GI Disorders & Motility Disorders Working Group of the National Commission on Digestive Diseases (NCDD) of the NIH Member, GI Working Group for “America’s Best Children’s Hospitals” for U.S. News & World Report Member, Scientific Advisory Board (SAB) of the Children’s Digestive Health and Nutrition Foundation (CDHNF) Member, Scientific Advisory Board of the University of North Carolina (UNC) Center for Functional GI and Motility Disorders Member, Sub-board of Pediatric Gastroenterology of the American Board of Pediatrics (ABP)

Research

Publications

                  Hawa K, Janse S, Lee J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Providing a Constipation Action Plan to Families of Children With Constipation Decreases Health Care Utilization. J Pediatr Gastroenterol Nutr. 2022 Nov 1; 75: 589-594.

                


                  Hawa K, Lu PL, Holzmacher M, Wall J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Van Diest AK. INTENSIVE OUTPATIENT TREATMENT OF PEDIATRIC RUMINATION SYNDROME IN THE ERA OF TELEMEDICINE. J Pediatr Gastroenterol Nutr. 2022 Jul 28;  

                


                  Baaleman DF, Hallagan A, Halleran DR, Orsagh-Yentis DK, Levitt MA, Wood RJ, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. Anal Botulinum Toxin in Children with Hirschsprung Disease and Functional Constipation: A Prospective Cohort study. Eur J Pediatr Surg. 2022 Jul 19;  

                


                  Baaleman DF, Vriesman MH, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL, Koppen IJN. Do we need an extra dimension? A pilot study on the use of three-dimensional anorectal manometry in children with functional constipation. Neurogastroenterol Motil. 2022 Apr 4;  e14370.

                


                  Baaleman DF, Vriesman MH, Koppen IJN, Osborne KM, Benninga MA, Saps M, Yacob D, Lu PL, Woodley FW, Lorenzo CD. Hypnosis to Reduce Distress in Children Undergoing Anorectal Manometry: A Randomized Controlled Pilot Trial. J Neurogastroenterol Motil. 2022 Apr 30; 28: 312-319.

                


                  Di Lorenzo C. Functional Nausea Is Real and Makes You Sick. Front Pediatr. 2022; 10: 848659.

                


                  Nurko S, Saps M, Kossovsky J, Zion SR, Di Lorenzo C, Vaz K, Hawthorne K, Wu R, Ciciora S, Rosen JM, Kaptchuk TJ, Kelley JM. Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial. JAMA Pediatr. 2022 Jan 31;  

                


                  Strisciuglio C, Martinelli M, Lu P, Bar Lev MR, Beinvogl B, Benninga MA, Di Lorenzo C, Fiori Nastro F, Nurko S, Pearlstein H, Rosen R, Shamir R, Staiano A. Overall Impact of Coronavirus Disease 2019 Outbreak in Children With Functional Abdominal Pain Disorders: Results From the First Pandemic Phase. J Pediatr Gastroenterol Nutr. 2021 Dec 1; 73: 689-694.

                


                  Ahmad H, Levitt MA, Yacob D, Halleran DR, Gasior AC, Di Lorenzo C, Wood RJ, Langer JC. Evaluation and Management of Persistent Problems After Surgery for Hirschsprung Disease in a Child. Curr Gastroenterol Rep. 2021 Oct 11; 23: 18.

                


                  Orsagh-Yentis DK, Ryan K, Hurwitz N, Diefenbach KA, Teich S, Mousa H, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Gastric electrical stimulation improves symptoms and need for supplemental nutrition in children with severe nausea and vomiting: A ten-year experience. Neurogastroenterol Motil. 2021 Sep; 33: e14199.

                


                  Saps M, Nurko S, Benninga MA, Di Lorenzo C, Garza JM, Thapar N, Richards K, Lee JJ, Altepeter T. A Collaborative Effort to Advance Drug Development in Pediatric Constipation and Irritable Bowel Syndrome. J Pediatr Gastroenterol Nutr. 2021 Aug 1; 73: 145-149.

                


                  Madani S, Madani R, Parikh S, Manivannan A, Orellana WR, Thomas R, Di Lorenzo C. Symptomatic Treatment of Pain-Related Pediatric Functional Gastrointestinal Disorders in a Biopsychosocial Construct, and a Validity Study of Rome III Criteria. Clin Pediatr (Phila). 2021 Jun; 60: 304-313.

                


                  Baaleman DF, Gupta S, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The Use of Linaclotide in Children with Functional Constipation or Irritable Bowel Syndrome: A Retrospective Chart Review. Paediatr Drugs. 2021 May; 23: 307-314.

                


                  Abdulkader ZM, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Predictors of Hospital Admission for Pediatric Cyclic Vomiting Syndrome. J Pediatr. 2021 May; 232: 154-158.

                


                  Benninga MA, Hussain SZ, Sood MR, Nurko S, Hyman P, Clifford RA, O'Gorman M, Losch-Beridon T, Mareya S, Lichtlen P, Di Lorenzo C. Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-Blind Study With Long-term Extension. Clin Gastroenterol Hepatol. 2021 Apr 7;  

                


                  Seilhamer C, Di Lorenzo C, Holstine J, Samora JB. Creating a bowel management plan for pediatric orthopaedic spine surgery patients. Spine Deform. 2021 Mar; 9: 365-371.

                


                  Elfar W, Gurjar AA, Talukder MAH, Noble M, Di Lorenzo C, Elfar J. Erythropoietin promotes functional recovery in a mouse model of postoperative ileus. Neurogastroenterol Motil. 2021 Feb; 33: e14049.

                


                  Khlevner J, Rosen R, Ambartsumyan L, Lusman SS, Rosen JM, Yacob D, Mousa H, Nurko S, Di Lorenzo C, Boruta M, Ratcliffe EM, Feinstein L, Snyder J, Wood RJ, Graham K, Saps M, Gyawali CP, Rodriguez L, Belkind-Gerson J. Development of Entrustable Professional Activities and Standards in Training in Pediatric Neurogastroenterology and Motility: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and American Neurogastroenterology and Motility Society Position Paper. J Pediatr Gastroenterol Nutr. 2021 Jan 1; 72: 168-180.

                


                  Yacob D, Kroon Van Diest AM, Di Lorenzo C. Functional abdominal pain in adolescents: case-based management. Frontline Gastroenterol. 2021; 12: 629-635.

                


                  Baaleman DF, Malamisura M, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The not-so-rare absent RAIR: Internal anal sphincter achalasia in a review of 1072 children with constipation undergoing high-resolution anorectal manometry. Neurogastroenterol Motil. 2020 Dec 10;  e14028.

                


                  Jadcherla SR, Hasenstab KA, Wei L, Osborn EK, Viswanathan S, Gulati IK, Slaughter JL, Di Lorenzo C. Role of feeding strategy bundle with acid-suppressive therapy in infants with esophageal acid reflux exposure: a randomized controlled trial. Pediatr Res. 2020 May 7;  

                


                  Jadcherla SR, Sultana Z, Hasenstab-Kenney KA, Prabhakar V, Gulati IK, Di Lorenzo C. Differentiating esophageal sensitivity phenotypes using pH-impedance in intensive care unit infants referred for gastroesophageal reflux symptoms. Pediatr Res. 2020 May 6;  

                


                  Di Lorenzo C. Gastroparesis in children: Paralysis for the child or the provider? Neurogastroenterol Motil. 2020 Mar; 32: e13792.

                


                  Chumpitazi BP, Lewis J, Cooper D, D'Amato M, Lim J, Gupta S, Miranda A, Terry N, Mehta D, Scheimann A, O'Gorman M, Tipnis N, Davies Y, Friedlander J, Smith H, Punati J, Khlevner J, Setty M, Di Lorenzo C. Hypomorphic SI genetic variants are associated with childhood chronic loose stools. PLoS One. 2020; 15: e0231891.

                


                  Halleran DR, Lu PL, Ahmad H, Paradiso MM, Lehmkuhl H, Akers A, Hallagan A, Bali N, Vaz K, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. Anal sphincter botulinum toxin injection in children with functional anorectal and colonic disorders: A large institutional study and review of the literature focusing on complications. J Pediatr Surg. 2019 Nov; 54: 2305-2310.

                


                  Corsetti M, Costa M, Bassotti G, Bharucha AE, Borrelli O, Dinning P, Di Lorenzo C, Huizinga JD, Jimenez M, Rao S, Spiller R, Spencer NJ, Lentle R, Pannemans J, Thys A, Benninga M, Tack J. First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nat Rev Gastroenterol Hepatol. 2019 Jul 11;  

                


                  Di Lorenzo C, Nurko S. It's Ok to be Negative! J Pediatr Gastroenterol Nutr. 2019 Jun 17;  

                


                  Murray HB, Juarascio AS, Di Lorenzo C, Drossman DA, Thomas JJ. Diagnosis and Treatment of Rumination Syndrome: A Critical Review. Am J Gastroenterol. 2019 Apr; 114: 562-578.

                


                  Vilanova-Sanchez A, Halleran DR, Reck-Burneo CA, Gasior AC, Weaver L, Fisher M, Wagner A, Nash O, Booth K, Peters K, Williams C, Brown SM, Lu P, Fuchs M, Diefenbach K, Leonard JR, Hewitt G, McCracken K, Di Lorenzo C, Wood RJ, Levitt MA. A descriptive model for a multidisciplinary unit for colorectal and pelvic malformations. J Pediatr Surg. 2019 Mar; 54: 479-485.

                


                  Di Lorenzo C. 2018 Harry Shwachman Award. J Pediatr Gastroenterol Nutr. 2019 Mar; 68: 291.

                


                  Halleran DR, Vilanova-Sanchez A, Rentea RM, Vriesman MH, Maloof T, Lu PL, Onwuka A, Weaver L, Vaz KK, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. A comparison of Malone appendicostomy and cecostomy for antegrade access as adjuncts to a bowel management program for patients with functional constipation or fecal incontinence. J Pediatr Surg. 2019 Jan; 54: 123-128.

                


                  Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ. Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference. Gastroenterology. 2018 Sep 6;  

                


                  Gasior A, Reck C, Vilanova-Sanchez A, Diefenbach KA, Yacob D, Lu P, Vaz K, Di Lorenzo C, Levitt MA, Wood RJ. Surgical management of functional constipation: An intermediate report of a new approach using a laparoscopic sigmoid resection combined with malone appendicostomy. J Pediatr Surg. 2018 Jun; 53: 1160-1162.

                


                  Thapar N, Saliakellis E, Benninga MA, Borrelli O, Curry J, Faure C, De Giorgio R, Gupte G, Knowles CH, Staiano A, Vandenplas Y, Di Lorenzo C. Paediatric Intestinal Pseudo-obstruction: Evidence and Consensus-based Recommendations From an ESPGHAN-Led Expert Group. J Pediatr Gastroenterol Nutr. 2018 Jun; 66: 991-1019.

                


                  Saps M, Lavigne JV, van Tilburg MA, Miranda A, Benninga MA, Taminiau JA, Di Lorenzo C. Endpoints, reliability, and meaningful changes in clinical trials for children with irritable bowel syndrome. The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 May; 30: e13308.

                


                  Koppen IJN, Vriesman MH, Tabbers MM, Di Lorenzo C, Benninga MA. Awareness and Implementation of the 2014 ESPGHAN/NASPGHAN Guideline for Childhood Functional Constipation. J Pediatr Gastroenterol Nutr. 2018 May; 66: 732-737.

                


                  Di Lorenzo C. 2017 NASPGHAN Distinguished Service Award. J Pediatr Gastroenterol Nutr. 2018 May; 66: 713-714.

                


                  Koppen IJN, Vriesman MH, Saps M, Rajindrajith S, Shi X, van Etten-Jamaludin FS, Di Lorenzo C, Benninga MA, Tabbers MM. Prevalence of Functional Defecation Disorders in Children: A Systematic Review and Meta-Analysis. J Pediatr. 2018 Apr 12;  

                


                  Koppen IJN, Saps M, Lavigne JV, Nurko S, Taminiau JAJM, Di Lorenzo C, Benninga MA. Recommendations for pharmacological clinical trials in children with functional constipation: The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 Apr; 30: e13294.

                


                  Williams KC, Rogers LK, Hill I, Barnard J, Di Lorenzo C. PEG 3350 Administration Is Not Associated with Sustained Elevation of Glycol Levels. J Pediatr. 2018 Apr; 195: 148-153.e1.

                


                  Robin SG, Keller C, Zwiener R, Hyman PE, Nurko S, Saps M, Di Lorenzo C, Shulman RJ, Hyams JS, Palsson O, van Tilburg MAL. Prevalence of Pediatric Functional Gastrointestinal Disorders Utilizing the Rome IV Criteria. J Pediatr. 2018 Apr; 195: 134-139.

                


                  Manini ML, Camilleri M, Grothe R, Di Lorenzo C. Application of Pyridostigmine in Pediatric Gastrointestinal Motility Disorders: A Case Series. Paediatr Drugs. 2018 Apr; 20: 173-180.

                


                  Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, Gupta S, Langendam M, Staiano A, Thapar N, Tipnis N, Tabbers M. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2018 Mar; 66: 516-554.

                


                  Chang L, Di Lorenzo C, Farrugia G, Hamilton FA, Mawe GM, Pasricha PJ, Wiley JW. Functional Bowel Disorders: A Roadmap to Guide the Next Generation of Research. Gastroenterology. 2018 Feb; 154: 723-735.

                


                  Lu PL, Koppen IJN, Orsagh-Yentis DK, Leonhart K, Ambeba EJ, Deans KJ, Minneci PC, Teich S, Diefenbach KA, Alpert SA, Benninga MA, Yacob D, Di Lorenzo C. Sacral nerve stimulation for constipation and fecal incontinence in children: Long-term outcomes, patient benefit, and parent satisfaction. Neurogastroenterol Motil. 2018 Feb; 30: 

                


                  Kuizenga-Wessel S, Koppen IJN, Vriesman MH, Di Lorenzo C, van Dijk M, Beelen MLR, Groeneweg M, Stoffelsen RJ, Benninga MA. Attention Deficit Hyperactivity Disorder and Functional Defecation Disorders in Children. J Pediatr Gastroenterol Nutr. 2018 Feb; 66: 244-249.

                


                  Alioto A, Di Lorenzo C. Long-term Follow-up of Adolescents Treated for Rumination Syndrome in an Inpatient Setting. J Pediatr Gastroenterol Nutr. 2018 Jan; 66: 21-25.

                


                  Vriesman MH, Velasco-Benitez CA, Ramirez CR, Benninga MA, Di Lorenzo C, Saps M. Assessing Children's Report of Stool Consistency: Agreement Between the Pediatric Rome III Questionnaire and the Bristol Stool Scale. J Pediatr. 2017 Nov; 190: 69-73.

                


                  Koppen IJN, Thompson BP, Ambeba EJ, Lane VA, Bates DG, Minneci PC, Deans KJ, Levitt MA, Wood RJ, Benninga MA, Di Lorenzo C, Yacob D. Segmental colonic dilation is associated with premature termination of high-amplitude propagating contractions in children with intractable functional constipation. Neurogastroenterol Motil. 2017 Oct; 29: 1-9.

                


                  Woodley FW, Moore-Clingenpeel M, Machado RS, Nemastil CJ, Jadcherla SR, Hayes D Jr, Kopp BT, Kaul A, Di Lorenzo C, Mousa H. Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux. Pediatr Gastroenterol Hepatol Nutr. 2017 Sep; 20: 153-159.

                


                  Alioto A, Di Lorenzo C, Montgomery ML, Yacob D. High Cost and Low Yield: The Diagnostic Evaluation of Rumination Syndrome in Pediatrics. J Pediatr. 2017 Jun; 185: 155-159.

                


                  Kuizenga-Wessel S, Koppen IJN, Zwager LW, Di Lorenzo C, de Jong JR, Benninga MA. Surgical management of children with intractable functional constipation; experience of a single tertiary children's hospital. Neurogastroenterol Motil. 2017 May; 29: 

                


                  Lu PL, Asti L, Lodwick DL, Nacion KM, Deans KJ, Minneci PC, Teich S, Alpert SA, Yacob D, Di Lorenzo C, Mousa HM. Sacral nerve stimulation allows for decreased antegrade continence enema use in children with severe constipation. J Pediatr Surg. 2017 Apr; 52: 558-562.

                


                  Vandenplas Y, Szajewska H, Benninga M, Di Lorenzo C, Dupont C, Faure C, Miqdadi M, Osatakul S, Ribes-Konickx C, Saps M, Shamir R, Staiano A, BITSS Study Group.. Development of the Brussels Infant and Toddler Stool Scale ('BITSS'): protocol of the study. BMJ Open. 2017 Mar 29; 7: e014620.

                


                  Koppen IJ, Yacob D, Di Lorenzo C, Saps M, Benninga MA, Cooper JN, Minneci PC, Deans KJ, Bates DG, Thompson BP. Assessing colonic anatomy normal values based on air contrast enemas in children younger than 6 years. Pediatr Radiol. 2017 Mar; 47: 306-312.

                


                  Peeters B, Vriesman MH, Koppen IJN, van Dijk M, Grootenhuis MA, Di Lorenzo C, Benninga MA. Parental characteristics and functional constipation in children: a cross-sectional cohort study. BMJ Paediatr Open. 2017; 1: e000100.

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Education

Date of Appointment at Nationwide Children’s Hospital: 08/27/2004

Board Certifications

Pediatric Gastroenterology

Fellowship

Harbor UCLA Medical Center

Date Completed: 06/30/1990

Fellowship

University of Southern California County Hospital

Date Completed: 04/30/1988

Fellowship

Hospital Universitaire des Enfants - Brussels

Date Completed: 12/31/1986

Residency

2nd University of Naples - Italy

Date Completed: 07/31/1988

Internship

2nd University of Naples - Italy

Date Completed: 07/31/1986

Medical School

2nd University of Naples - Italy

Date Completed: 07/31/1984

Contact Information

Pediatrics

Call us at: (614) 722-3450

Fax us at: (614) 722-3454

                    Gastroenterology & Hepatology & Nutrition700 Children's DrColumbus, OH 43205 (map)

Connect with Carlo Di Lorenzo

Connect on Twitter

Contact Information

Call us at: (614) 722-3450

Fax us at: (614) 722-3454

PediatricsGastroenterology & Hepatology & Nutrition700 Children’s DrColumbus, OH 43205 (map)

Learn more about Carlo Di Lorenzo

Contact Information

• Call us at:
• (614) 722-3450
• Fax us at:
• (614) 722-3454
• PediatricsGastroenterology & Hepatology & Nutrition700 Children’s DrColumbus, OH 43205 (map)

Learn more about Carlo Di Lorenzo

Biography

Carlo Di Lorenzo, MD, is Chief of the Division of Pediatric Gastroenterology, Hepatology and Nutrition at Nationwide Children’s Hospital where he holds the Robert F. and Edgar T. Wolfe Foundation Endowed Chair in Pediatric Gastroenterology and Professor of Clinical Pediatrics at The Ohio State University College of Medicine. Dr. Di Lorenzo has been among the first clinical investigators to assess the diagnostic value of antroduodenal and colonic manometry and to use the electronic barostat to assess visceral sensitivity in children. He co-authored the only three books on pediatric gastrointestinal motility, and has published more than 300 peer-reviewed original articles, chapters, invited reviews and editorials. He has been awarded the Master Award in Gastroenterology for Basic or Clinical research in Gastroenterology by the AGAI, the Golden Stethoscope Award by Nationwide Children’s Hospital and the Award for Senior Investigator in Pediatrics by the IFFGD. He has been President of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Named multiple times among the “Best Doctors in America," Dr. Di Lorenzo has served on the editorial board of the Journal of Pediatric Gastroenterology, Hepatology and Nutrition and the Journal of Neurogastroenterology and Motility. He has functioned as a grant reviewer for the National Institutes of Health and abstract reviewer for the American Gastroenterological Association (AGA). Dr. Di Lorenzo has also held prominent roles in numerous national and international organizations and work groups, including:

Chair of the American Academy of Pediatrics (AAP) subcommittee to develop evaluation and treatment guidelines for functional abdominal pain Chair of the Functional Gastrointestinal Disorders and Neurogastroenterology working group of the second World Congress of Pediatric Gastroenterology Chair of the American Neurogastroenterology and Motility Society (ANMS) committee for the development of minimal standards for motility testing in children Chair of the Adolescent Committee of the Rome III and Rome IV criteria Chair of the Growth, Development and Child Health Section of the American Gastroenterology Association

Biography

Carlo Di Lorenzo, MD, is Chief of the Division of Pediatric Gastroenterology, Hepatology and Nutrition at Nationwide Children’s Hospital where he holds the Robert F. and Edgar T. Wolfe Foundation Endowed Chair in Pediatric Gastroenterology and Professor of Clinical Pediatrics at The Ohio State University College of Medicine. Dr. Di Lorenzo has been among the first clinical investigators to assess the diagnostic value of antroduodenal and colonic manometry and to use the electronic barostat to assess visceral sensitivity in children. He co-authored the only three books on pediatric gastrointestinal motility, and has published more than 300 peer-reviewed original articles, chapters, invited reviews and editorials. He has been awarded the Master Award in Gastroenterology for Basic or Clinical research in Gastroenterology by the AGAI, the Golden Stethoscope Award by Nationwide Children’s Hospital and the Award for Senior Investigator in Pediatrics by the IFFGD. He has been President of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Named multiple times among the “Best Doctors in America," Dr. Di Lorenzo has served on the editorial board of the Journal of Pediatric Gastroenterology, Hepatology and Nutrition and the Journal of Neurogastroenterology and Motility. He has functioned as a grant reviewer for the National Institutes of Health and abstract reviewer for the American Gastroenterological Association (AGA). Dr. Di Lorenzo has also held prominent roles in numerous national and international organizations and work groups, including:

Chair of the American Academy of Pediatrics (AAP) subcommittee to develop evaluation and treatment guidelines for functional abdominal pain Chair of the Functional Gastrointestinal Disorders and Neurogastroenterology working group of the second World Congress of Pediatric Gastroenterology Chair of the American Neurogastroenterology and Motility Society (ANMS) committee for the development of minimal standards for motility testing in children Chair of the Adolescent Committee of the Rome III and Rome IV criteria Chair of the Growth, Development and Child Health Section of the American Gastroenterology Association

Biography

Carlo Di Lorenzo, MD, is Chief of the Division of Pediatric Gastroenterology, Hepatology and Nutrition at Nationwide Children’s Hospital where he holds the Robert F. and Edgar T. Wolfe Foundation Endowed Chair in Pediatric Gastroenterology and Professor of Clinical Pediatrics at The Ohio State University College of Medicine. Dr. Di Lorenzo has been among the first clinical investigators to assess the diagnostic value of antroduodenal and colonic manometry and to use the electronic barostat to assess visceral sensitivity in children. He co-authored the only three books on pediatric gastrointestinal motility, and has published more than 300 peer-reviewed original articles, chapters, invited reviews and editorials. He has been awarded the Master Award in Gastroenterology for Basic or Clinical research in Gastroenterology by the AGAI, the Golden Stethoscope Award by Nationwide Children’s Hospital and the Award for Senior Investigator in Pediatrics by the IFFGD. He has been President of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Named multiple times among the “Best Doctors in America," Dr. Di Lorenzo has served on the editorial board of the Journal of Pediatric Gastroenterology, Hepatology and Nutrition and the Journal of Neurogastroenterology and Motility. He has functioned as a grant reviewer for the National Institutes of Health and abstract reviewer for the American Gastroenterological Association (AGA). Dr. Di Lorenzo has also held prominent roles in numerous national and international organizations and work groups, including:

Chair of the American Academy of Pediatrics (AAP) subcommittee to develop evaluation and treatment guidelines for functional abdominal pain Chair of the Functional Gastrointestinal Disorders and Neurogastroenterology working group of the second World Congress of Pediatric Gastroenterology Chair of the American Neurogastroenterology and Motility Society (ANMS) committee for the development of minimal standards for motility testing in children Chair of the Adolescent Committee of the Rome III and Rome IV criteria Chair of the Growth, Development and Child Health Section of the American Gastroenterology Association

Carlo Di Lorenzo, MD, is Chief of the Division of Pediatric Gastroenterology, Hepatology and Nutrition at Nationwide Children’s Hospital where he holds the Robert F. and Edgar T. Wolfe Foundation Endowed Chair in Pediatric Gastroenterology and Professor of Clinical Pediatrics at The Ohio State University College of Medicine. Dr. Di Lorenzo has been among the first clinical investigators to assess the diagnostic value of antroduodenal and colonic manometry and to use the electronic barostat to assess visceral sensitivity in children. He co-authored the only three books on pediatric gastrointestinal motility, and has published more than 300 peer-reviewed original articles, chapters, invited reviews and editorials. He has been awarded the Master Award in Gastroenterology for Basic or Clinical research in Gastroenterology by the AGAI, the Golden Stethoscope Award by Nationwide Children’s Hospital and the Award for Senior Investigator in Pediatrics by the IFFGD. He has been President of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Named multiple times among the “Best Doctors in America," Dr. Di Lorenzo has served on the editorial board of the Journal of Pediatric Gastroenterology, Hepatology and Nutrition and the Journal of Neurogastroenterology and Motility. He has functioned as a grant reviewer for the National Institutes of Health and abstract reviewer for the American Gastroenterological Association (AGA). Dr. Di Lorenzo has also held prominent roles in numerous national and international organizations and work groups, including:

Chair of the American Academy of Pediatrics (AAP) subcommittee to develop evaluation and treatment guidelines for functional abdominal pain Chair of the Functional Gastrointestinal Disorders and Neurogastroenterology working group of the second World Congress of Pediatric Gastroenterology Chair of the American Neurogastroenterology and Motility Society (ANMS) committee for the development of minimal standards for motility testing in children Chair of the Adolescent Committee of the Rome III and Rome IV criteria Chair of the Growth, Development and Child Health Section of the American Gastroenterology Association

Carlo Di Lorenzo, MD, is Chief of the Division of Pediatric Gastroenterology, Hepatology and Nutrition at Nationwide Children’s Hospital where he holds the Robert F. and Edgar T. Wolfe Foundation Endowed Chair in Pediatric Gastroenterology and Professor of Clinical Pediatrics at The Ohio State University College of Medicine. Dr. Di Lorenzo has been among the first clinical investigators to assess the diagnostic value of antroduodenal and colonic manometry and to use the electronic barostat to assess visceral sensitivity in children. He co-authored the only three books on pediatric gastrointestinal motility, and has published more than 300 peer-reviewed original articles, chapters, invited reviews and editorials. He has been awarded the Master Award in Gastroenterology for Basic or Clinical research in Gastroenterology by the AGAI, the Golden Stethoscope Award by Nationwide Children’s Hospital and the Award for Senior Investigator in Pediatrics by the IFFGD. He has been President of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition.

Named multiple times among the “Best Doctors in America," Dr. Di Lorenzo has served on the editorial board of the Journal of Pediatric Gastroenterology, Hepatology and Nutrition and the Journal of Neurogastroenterology and Motility. He has functioned as a grant reviewer for the National Institutes of Health and abstract reviewer for the American Gastroenterological Association (AGA). Dr. Di Lorenzo has also held prominent roles in numerous national and international organizations and work groups, including:

• Chair of the American Academy of Pediatrics (AAP) subcommittee to develop evaluation and treatment guidelines for functional abdominal pain
• Chair of the Functional Gastrointestinal Disorders and Neurogastroenterology working group of the second World Congress of Pediatric Gastroenterology
• Chair of the American Neurogastroenterology and Motility Society (ANMS) committee for the development of minimal standards for motility testing in children
• Chair of the Adolescent Committee of the Rome III and Rome IV criteria
• Chair of the Growth, Development and Child Health Section of the American Gastroenterology Association

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English French Italian

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English French Italian

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English French Italian

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English French Italian

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English French Italian

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English French Italian

• Main Campus of Nationwide Children’s Hospital

• English

• French

• Italian

Academic and Clinical Areas

Gastroenterology, Hepatology & Nutrition

Division Chief

Motility

Director

Center for Colorectal and Pelvic Reconstruction

Physician Team

Rumination Syndrome Program

Director

Gastroenterology Motility Fellowship

Faculty

Pediatric Colorectal Research Fellowship

Faculty

Gastroenterology Fellowship

Faculty

Pediatric Colorectal Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Gastroenterology & Hepatology & Nutrition

Academic and Clinical Areas

Gastroenterology, Hepatology & Nutrition

Division Chief

Motility

Director

Center for Colorectal and Pelvic Reconstruction

Physician Team

Rumination Syndrome Program

Director

Gastroenterology Motility Fellowship

Faculty

Pediatric Colorectal Research Fellowship

Faculty

Gastroenterology Fellowship

Faculty

Pediatric Colorectal Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Gastroenterology & Hepatology & Nutrition

Academic and Clinical Areas

Gastroenterology, Hepatology & Nutrition

Division Chief

Motility

Director

Center for Colorectal and Pelvic Reconstruction

Physician Team

Rumination Syndrome Program

Director

Gastroenterology Motility Fellowship

Faculty

Pediatric Colorectal Research Fellowship

Faculty

Gastroenterology Fellowship

Faculty

Pediatric Colorectal Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Gastroenterology & Hepatology & Nutrition

Gastroenterology, Hepatology & Nutrition

Division Chief

Motility

Director

Center for Colorectal and Pelvic Reconstruction

Physician Team

Rumination Syndrome Program

Director

Gastroenterology Motility Fellowship

Faculty

Pediatric Colorectal Research Fellowship

Faculty

Gastroenterology Fellowship

Faculty

Pediatric Colorectal Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Gastroenterology & Hepatology & Nutrition

• Gastroenterology, Hepatology & Nutrition
• Division Chief
• Motility
• Director
• Center for Colorectal and Pelvic Reconstruction
• Physician Team
• Rumination Syndrome Program
• Director
• Gastroenterology Motility Fellowship
• Faculty
• Pediatric Colorectal Research Fellowship
• Faculty
• Gastroenterology Fellowship
• Faculty
• Pediatric Colorectal Fellowship
• Faculty
• Primary Department
• Pediatrics
• Primary Section
• Gastroenterology & Hepatology & Nutrition

Awards, Honors & Organizations

Golden Stethoscope Award Recipient, Nationwide Children’s Hospital, 2012 Listed, Best Doctors in America Board Member, United Mitochondrial Disease Foundation Chairman, Pediatric Slide Committee for the Rome III Initiative Council Member, Functional Bowel Group (FBG) Grant Reviewer, Thrasher Research Fund Member, Board for the “Small Intestine” section Faculty of 1000 Medicine Member, Clinical Practice Committee of the American Motility Society Member, Editorial Boards of Journal of Pediatric Gastroenterology and Nutrition and Journal of Neurogastroenterology and Motility Member, Functional GI Disorders & Motility Disorders Working Group of the National Commission on Digestive Diseases (NCDD) of the NIH Member, GI Working Group for “America’s Best Children’s Hospitals” for U.S. News & World Report Member, Scientific Advisory Board (SAB) of the Children’s Digestive Health and Nutrition Foundation (CDHNF) Member, Scientific Advisory Board of the University of North Carolina (UNC) Center for Functional GI and Motility Disorders Member, Sub-board of Pediatric Gastroenterology of the American Board of Pediatrics (ABP)

Awards, Honors & Organizations

Golden Stethoscope Award Recipient, Nationwide Children’s Hospital, 2012 Listed, Best Doctors in America Board Member, United Mitochondrial Disease Foundation Chairman, Pediatric Slide Committee for the Rome III Initiative Council Member, Functional Bowel Group (FBG) Grant Reviewer, Thrasher Research Fund Member, Board for the “Small Intestine” section Faculty of 1000 Medicine Member, Clinical Practice Committee of the American Motility Society Member, Editorial Boards of Journal of Pediatric Gastroenterology and Nutrition and Journal of Neurogastroenterology and Motility Member, Functional GI Disorders & Motility Disorders Working Group of the National Commission on Digestive Diseases (NCDD) of the NIH Member, GI Working Group for “America’s Best Children’s Hospitals” for U.S. News & World Report Member, Scientific Advisory Board (SAB) of the Children’s Digestive Health and Nutrition Foundation (CDHNF) Member, Scientific Advisory Board of the University of North Carolina (UNC) Center for Functional GI and Motility Disorders Member, Sub-board of Pediatric Gastroenterology of the American Board of Pediatrics (ABP)

Awards, Honors & Organizations

Golden Stethoscope Award Recipient, Nationwide Children’s Hospital, 2012 Listed, Best Doctors in America Board Member, United Mitochondrial Disease Foundation Chairman, Pediatric Slide Committee for the Rome III Initiative Council Member, Functional Bowel Group (FBG) Grant Reviewer, Thrasher Research Fund Member, Board for the “Small Intestine” section Faculty of 1000 Medicine Member, Clinical Practice Committee of the American Motility Society Member, Editorial Boards of Journal of Pediatric Gastroenterology and Nutrition and Journal of Neurogastroenterology and Motility Member, Functional GI Disorders & Motility Disorders Working Group of the National Commission on Digestive Diseases (NCDD) of the NIH Member, GI Working Group for “America’s Best Children’s Hospitals” for U.S. News & World Report Member, Scientific Advisory Board (SAB) of the Children’s Digestive Health and Nutrition Foundation (CDHNF) Member, Scientific Advisory Board of the University of North Carolina (UNC) Center for Functional GI and Motility Disorders Member, Sub-board of Pediatric Gastroenterology of the American Board of Pediatrics (ABP)

Golden Stethoscope Award Recipient, Nationwide Children’s Hospital, 2012 Listed, Best Doctors in America Board Member, United Mitochondrial Disease Foundation Chairman, Pediatric Slide Committee for the Rome III Initiative Council Member, Functional Bowel Group (FBG) Grant Reviewer, Thrasher Research Fund Member, Board for the “Small Intestine” section Faculty of 1000 Medicine Member, Clinical Practice Committee of the American Motility Society Member, Editorial Boards of Journal of Pediatric Gastroenterology and Nutrition and Journal of Neurogastroenterology and Motility Member, Functional GI Disorders & Motility Disorders Working Group of the National Commission on Digestive Diseases (NCDD) of the NIH Member, GI Working Group for “America’s Best Children’s Hospitals” for U.S. News & World Report Member, Scientific Advisory Board (SAB) of the Children’s Digestive Health and Nutrition Foundation (CDHNF) Member, Scientific Advisory Board of the University of North Carolina (UNC) Center for Functional GI and Motility Disorders Member, Sub-board of Pediatric Gastroenterology of the American Board of Pediatrics (ABP)

• Golden Stethoscope Award Recipient, Nationwide Children’s Hospital, 2012
• Listed, Best Doctors in America
• Board Member, United Mitochondrial Disease Foundation
• Chairman, Pediatric Slide Committee for the Rome III Initiative
• Council Member, Functional Bowel Group (FBG)
• Grant Reviewer, Thrasher Research Fund
• Member, Board for the “Small Intestine” section Faculty of 1000 Medicine
• Member, Clinical Practice Committee of the American Motility Society
• Member, Editorial Boards of Journal of Pediatric Gastroenterology and Nutrition and Journal of Neurogastroenterology and Motility
• Member, Functional GI Disorders & Motility Disorders Working Group of the National Commission on Digestive Diseases (NCDD) of the NIH
• Member, GI Working Group for “America’s Best Children’s Hospitals” for U.S. News & World Report
• Member, Scientific Advisory Board (SAB) of the Children’s Digestive Health and Nutrition Foundation (CDHNF)
• Member, Scientific Advisory Board of the University of North Carolina (UNC) Center for Functional GI and Motility Disorders
• Member, Sub-board of Pediatric Gastroenterology of the American Board of Pediatrics (ABP)

Research

Publications

                  Hawa K, Janse S, Lee J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Providing a Constipation Action Plan to Families of Children With Constipation Decreases Health Care Utilization. J Pediatr Gastroenterol Nutr. 2022 Nov 1; 75: 589-594.

                


                  Hawa K, Lu PL, Holzmacher M, Wall J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Van Diest AK. INTENSIVE OUTPATIENT TREATMENT OF PEDIATRIC RUMINATION SYNDROME IN THE ERA OF TELEMEDICINE. J Pediatr Gastroenterol Nutr. 2022 Jul 28;  

                


                  Baaleman DF, Hallagan A, Halleran DR, Orsagh-Yentis DK, Levitt MA, Wood RJ, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. Anal Botulinum Toxin in Children with Hirschsprung Disease and Functional Constipation: A Prospective Cohort study. Eur J Pediatr Surg. 2022 Jul 19;  

                


                  Baaleman DF, Vriesman MH, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL, Koppen IJN. Do we need an extra dimension? A pilot study on the use of three-dimensional anorectal manometry in children with functional constipation. Neurogastroenterol Motil. 2022 Apr 4;  e14370.

                


                  Baaleman DF, Vriesman MH, Koppen IJN, Osborne KM, Benninga MA, Saps M, Yacob D, Lu PL, Woodley FW, Lorenzo CD. Hypnosis to Reduce Distress in Children Undergoing Anorectal Manometry: A Randomized Controlled Pilot Trial. J Neurogastroenterol Motil. 2022 Apr 30; 28: 312-319.

                


                  Di Lorenzo C. Functional Nausea Is Real and Makes You Sick. Front Pediatr. 2022; 10: 848659.

                


                  Nurko S, Saps M, Kossovsky J, Zion SR, Di Lorenzo C, Vaz K, Hawthorne K, Wu R, Ciciora S, Rosen JM, Kaptchuk TJ, Kelley JM. Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial. JAMA Pediatr. 2022 Jan 31;  

                


                  Strisciuglio C, Martinelli M, Lu P, Bar Lev MR, Beinvogl B, Benninga MA, Di Lorenzo C, Fiori Nastro F, Nurko S, Pearlstein H, Rosen R, Shamir R, Staiano A. Overall Impact of Coronavirus Disease 2019 Outbreak in Children With Functional Abdominal Pain Disorders: Results From the First Pandemic Phase. J Pediatr Gastroenterol Nutr. 2021 Dec 1; 73: 689-694.

                


                  Ahmad H, Levitt MA, Yacob D, Halleran DR, Gasior AC, Di Lorenzo C, Wood RJ, Langer JC. Evaluation and Management of Persistent Problems After Surgery for Hirschsprung Disease in a Child. Curr Gastroenterol Rep. 2021 Oct 11; 23: 18.

                


                  Orsagh-Yentis DK, Ryan K, Hurwitz N, Diefenbach KA, Teich S, Mousa H, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Gastric electrical stimulation improves symptoms and need for supplemental nutrition in children with severe nausea and vomiting: A ten-year experience. Neurogastroenterol Motil. 2021 Sep; 33: e14199.

                


                  Saps M, Nurko S, Benninga MA, Di Lorenzo C, Garza JM, Thapar N, Richards K, Lee JJ, Altepeter T. A Collaborative Effort to Advance Drug Development in Pediatric Constipation and Irritable Bowel Syndrome. J Pediatr Gastroenterol Nutr. 2021 Aug 1; 73: 145-149.

                


                  Madani S, Madani R, Parikh S, Manivannan A, Orellana WR, Thomas R, Di Lorenzo C. Symptomatic Treatment of Pain-Related Pediatric Functional Gastrointestinal Disorders in a Biopsychosocial Construct, and a Validity Study of Rome III Criteria. Clin Pediatr (Phila). 2021 Jun; 60: 304-313.

                


                  Baaleman DF, Gupta S, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The Use of Linaclotide in Children with Functional Constipation or Irritable Bowel Syndrome: A Retrospective Chart Review. Paediatr Drugs. 2021 May; 23: 307-314.

                


                  Abdulkader ZM, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Predictors of Hospital Admission for Pediatric Cyclic Vomiting Syndrome. J Pediatr. 2021 May; 232: 154-158.

                


                  Benninga MA, Hussain SZ, Sood MR, Nurko S, Hyman P, Clifford RA, O'Gorman M, Losch-Beridon T, Mareya S, Lichtlen P, Di Lorenzo C. Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-Blind Study With Long-term Extension. Clin Gastroenterol Hepatol. 2021 Apr 7;  

                


                  Seilhamer C, Di Lorenzo C, Holstine J, Samora JB. Creating a bowel management plan for pediatric orthopaedic spine surgery patients. Spine Deform. 2021 Mar; 9: 365-371.

                


                  Elfar W, Gurjar AA, Talukder MAH, Noble M, Di Lorenzo C, Elfar J. Erythropoietin promotes functional recovery in a mouse model of postoperative ileus. Neurogastroenterol Motil. 2021 Feb; 33: e14049.

                


                  Khlevner J, Rosen R, Ambartsumyan L, Lusman SS, Rosen JM, Yacob D, Mousa H, Nurko S, Di Lorenzo C, Boruta M, Ratcliffe EM, Feinstein L, Snyder J, Wood RJ, Graham K, Saps M, Gyawali CP, Rodriguez L, Belkind-Gerson J. Development of Entrustable Professional Activities and Standards in Training in Pediatric Neurogastroenterology and Motility: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and American Neurogastroenterology and Motility Society Position Paper. J Pediatr Gastroenterol Nutr. 2021 Jan 1; 72: 168-180.

                


                  Yacob D, Kroon Van Diest AM, Di Lorenzo C. Functional abdominal pain in adolescents: case-based management. Frontline Gastroenterol. 2021; 12: 629-635.

                


                  Baaleman DF, Malamisura M, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The not-so-rare absent RAIR: Internal anal sphincter achalasia in a review of 1072 children with constipation undergoing high-resolution anorectal manometry. Neurogastroenterol Motil. 2020 Dec 10;  e14028.

                


                  Jadcherla SR, Hasenstab KA, Wei L, Osborn EK, Viswanathan S, Gulati IK, Slaughter JL, Di Lorenzo C. Role of feeding strategy bundle with acid-suppressive therapy in infants with esophageal acid reflux exposure: a randomized controlled trial. Pediatr Res. 2020 May 7;  

                


                  Jadcherla SR, Sultana Z, Hasenstab-Kenney KA, Prabhakar V, Gulati IK, Di Lorenzo C. Differentiating esophageal sensitivity phenotypes using pH-impedance in intensive care unit infants referred for gastroesophageal reflux symptoms. Pediatr Res. 2020 May 6;  

                


                  Di Lorenzo C. Gastroparesis in children: Paralysis for the child or the provider? Neurogastroenterol Motil. 2020 Mar; 32: e13792.

                


                  Chumpitazi BP, Lewis J, Cooper D, D'Amato M, Lim J, Gupta S, Miranda A, Terry N, Mehta D, Scheimann A, O'Gorman M, Tipnis N, Davies Y, Friedlander J, Smith H, Punati J, Khlevner J, Setty M, Di Lorenzo C. Hypomorphic SI genetic variants are associated with childhood chronic loose stools. PLoS One. 2020; 15: e0231891.

                


                  Halleran DR, Lu PL, Ahmad H, Paradiso MM, Lehmkuhl H, Akers A, Hallagan A, Bali N, Vaz K, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. Anal sphincter botulinum toxin injection in children with functional anorectal and colonic disorders: A large institutional study and review of the literature focusing on complications. J Pediatr Surg. 2019 Nov; 54: 2305-2310.

                


                  Corsetti M, Costa M, Bassotti G, Bharucha AE, Borrelli O, Dinning P, Di Lorenzo C, Huizinga JD, Jimenez M, Rao S, Spiller R, Spencer NJ, Lentle R, Pannemans J, Thys A, Benninga M, Tack J. First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nat Rev Gastroenterol Hepatol. 2019 Jul 11;  

                


                  Di Lorenzo C, Nurko S. It's Ok to be Negative! J Pediatr Gastroenterol Nutr. 2019 Jun 17;  

                


                  Murray HB, Juarascio AS, Di Lorenzo C, Drossman DA, Thomas JJ. Diagnosis and Treatment of Rumination Syndrome: A Critical Review. Am J Gastroenterol. 2019 Apr; 114: 562-578.

                


                  Vilanova-Sanchez A, Halleran DR, Reck-Burneo CA, Gasior AC, Weaver L, Fisher M, Wagner A, Nash O, Booth K, Peters K, Williams C, Brown SM, Lu P, Fuchs M, Diefenbach K, Leonard JR, Hewitt G, McCracken K, Di Lorenzo C, Wood RJ, Levitt MA. A descriptive model for a multidisciplinary unit for colorectal and pelvic malformations. J Pediatr Surg. 2019 Mar; 54: 479-485.

                


                  Di Lorenzo C. 2018 Harry Shwachman Award. J Pediatr Gastroenterol Nutr. 2019 Mar; 68: 291.

                


                  Halleran DR, Vilanova-Sanchez A, Rentea RM, Vriesman MH, Maloof T, Lu PL, Onwuka A, Weaver L, Vaz KK, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. A comparison of Malone appendicostomy and cecostomy for antegrade access as adjuncts to a bowel management program for patients with functional constipation or fecal incontinence. J Pediatr Surg. 2019 Jan; 54: 123-128.

                


                  Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ. Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference. Gastroenterology. 2018 Sep 6;  

                


                  Gasior A, Reck C, Vilanova-Sanchez A, Diefenbach KA, Yacob D, Lu P, Vaz K, Di Lorenzo C, Levitt MA, Wood RJ. Surgical management of functional constipation: An intermediate report of a new approach using a laparoscopic sigmoid resection combined with malone appendicostomy. J Pediatr Surg. 2018 Jun; 53: 1160-1162.

                


                  Thapar N, Saliakellis E, Benninga MA, Borrelli O, Curry J, Faure C, De Giorgio R, Gupte G, Knowles CH, Staiano A, Vandenplas Y, Di Lorenzo C. Paediatric Intestinal Pseudo-obstruction: Evidence and Consensus-based Recommendations From an ESPGHAN-Led Expert Group. J Pediatr Gastroenterol Nutr. 2018 Jun; 66: 991-1019.

                


                  Saps M, Lavigne JV, van Tilburg MA, Miranda A, Benninga MA, Taminiau JA, Di Lorenzo C. Endpoints, reliability, and meaningful changes in clinical trials for children with irritable bowel syndrome. The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 May; 30: e13308.

                


                  Koppen IJN, Vriesman MH, Tabbers MM, Di Lorenzo C, Benninga MA. Awareness and Implementation of the 2014 ESPGHAN/NASPGHAN Guideline for Childhood Functional Constipation. J Pediatr Gastroenterol Nutr. 2018 May; 66: 732-737.

                


                  Di Lorenzo C. 2017 NASPGHAN Distinguished Service Award. J Pediatr Gastroenterol Nutr. 2018 May; 66: 713-714.

                


                  Koppen IJN, Vriesman MH, Saps M, Rajindrajith S, Shi X, van Etten-Jamaludin FS, Di Lorenzo C, Benninga MA, Tabbers MM. Prevalence of Functional Defecation Disorders in Children: A Systematic Review and Meta-Analysis. J Pediatr. 2018 Apr 12;  

                


                  Koppen IJN, Saps M, Lavigne JV, Nurko S, Taminiau JAJM, Di Lorenzo C, Benninga MA. Recommendations for pharmacological clinical trials in children with functional constipation: The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 Apr; 30: e13294.

                


                  Williams KC, Rogers LK, Hill I, Barnard J, Di Lorenzo C. PEG 3350 Administration Is Not Associated with Sustained Elevation of Glycol Levels. J Pediatr. 2018 Apr; 195: 148-153.e1.

                


                  Robin SG, Keller C, Zwiener R, Hyman PE, Nurko S, Saps M, Di Lorenzo C, Shulman RJ, Hyams JS, Palsson O, van Tilburg MAL. Prevalence of Pediatric Functional Gastrointestinal Disorders Utilizing the Rome IV Criteria. J Pediatr. 2018 Apr; 195: 134-139.

                


                  Manini ML, Camilleri M, Grothe R, Di Lorenzo C. Application of Pyridostigmine in Pediatric Gastrointestinal Motility Disorders: A Case Series. Paediatr Drugs. 2018 Apr; 20: 173-180.

                


                  Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, Gupta S, Langendam M, Staiano A, Thapar N, Tipnis N, Tabbers M. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2018 Mar; 66: 516-554.

                


                  Chang L, Di Lorenzo C, Farrugia G, Hamilton FA, Mawe GM, Pasricha PJ, Wiley JW. Functional Bowel Disorders: A Roadmap to Guide the Next Generation of Research. Gastroenterology. 2018 Feb; 154: 723-735.

                


                  Lu PL, Koppen IJN, Orsagh-Yentis DK, Leonhart K, Ambeba EJ, Deans KJ, Minneci PC, Teich S, Diefenbach KA, Alpert SA, Benninga MA, Yacob D, Di Lorenzo C. Sacral nerve stimulation for constipation and fecal incontinence in children: Long-term outcomes, patient benefit, and parent satisfaction. Neurogastroenterol Motil. 2018 Feb; 30: 

                


                  Kuizenga-Wessel S, Koppen IJN, Vriesman MH, Di Lorenzo C, van Dijk M, Beelen MLR, Groeneweg M, Stoffelsen RJ, Benninga MA. Attention Deficit Hyperactivity Disorder and Functional Defecation Disorders in Children. J Pediatr Gastroenterol Nutr. 2018 Feb; 66: 244-249.

                


                  Alioto A, Di Lorenzo C. Long-term Follow-up of Adolescents Treated for Rumination Syndrome in an Inpatient Setting. J Pediatr Gastroenterol Nutr. 2018 Jan; 66: 21-25.

                


                  Vriesman MH, Velasco-Benitez CA, Ramirez CR, Benninga MA, Di Lorenzo C, Saps M. Assessing Children's Report of Stool Consistency: Agreement Between the Pediatric Rome III Questionnaire and the Bristol Stool Scale. J Pediatr. 2017 Nov; 190: 69-73.

                


                  Koppen IJN, Thompson BP, Ambeba EJ, Lane VA, Bates DG, Minneci PC, Deans KJ, Levitt MA, Wood RJ, Benninga MA, Di Lorenzo C, Yacob D. Segmental colonic dilation is associated with premature termination of high-amplitude propagating contractions in children with intractable functional constipation. Neurogastroenterol Motil. 2017 Oct; 29: 1-9.

                


                  Woodley FW, Moore-Clingenpeel M, Machado RS, Nemastil CJ, Jadcherla SR, Hayes D Jr, Kopp BT, Kaul A, Di Lorenzo C, Mousa H. Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux. Pediatr Gastroenterol Hepatol Nutr. 2017 Sep; 20: 153-159.

                


                  Alioto A, Di Lorenzo C, Montgomery ML, Yacob D. High Cost and Low Yield: The Diagnostic Evaluation of Rumination Syndrome in Pediatrics. J Pediatr. 2017 Jun; 185: 155-159.

                


                  Kuizenga-Wessel S, Koppen IJN, Zwager LW, Di Lorenzo C, de Jong JR, Benninga MA. Surgical management of children with intractable functional constipation; experience of a single tertiary children's hospital. Neurogastroenterol Motil. 2017 May; 29: 

                


                  Lu PL, Asti L, Lodwick DL, Nacion KM, Deans KJ, Minneci PC, Teich S, Alpert SA, Yacob D, Di Lorenzo C, Mousa HM. Sacral nerve stimulation allows for decreased antegrade continence enema use in children with severe constipation. J Pediatr Surg. 2017 Apr; 52: 558-562.

                


                  Vandenplas Y, Szajewska H, Benninga M, Di Lorenzo C, Dupont C, Faure C, Miqdadi M, Osatakul S, Ribes-Konickx C, Saps M, Shamir R, Staiano A, BITSS Study Group.. Development of the Brussels Infant and Toddler Stool Scale ('BITSS'): protocol of the study. BMJ Open. 2017 Mar 29; 7: e014620.

                


                  Koppen IJ, Yacob D, Di Lorenzo C, Saps M, Benninga MA, Cooper JN, Minneci PC, Deans KJ, Bates DG, Thompson BP. Assessing colonic anatomy normal values based on air contrast enemas in children younger than 6 years. Pediatr Radiol. 2017 Mar; 47: 306-312.

                


                  Peeters B, Vriesman MH, Koppen IJN, van Dijk M, Grootenhuis MA, Di Lorenzo C, Benninga MA. Parental characteristics and functional constipation in children: a cross-sectional cohort study. BMJ Paediatr Open. 2017; 1: e000100.

View More Publications

Research

Publications

                  Hawa K, Janse S, Lee J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Providing a Constipation Action Plan to Families of Children With Constipation Decreases Health Care Utilization. J Pediatr Gastroenterol Nutr. 2022 Nov 1; 75: 589-594.

                


                  Hawa K, Lu PL, Holzmacher M, Wall J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Van Diest AK. INTENSIVE OUTPATIENT TREATMENT OF PEDIATRIC RUMINATION SYNDROME IN THE ERA OF TELEMEDICINE. J Pediatr Gastroenterol Nutr. 2022 Jul 28;  

                


                  Baaleman DF, Hallagan A, Halleran DR, Orsagh-Yentis DK, Levitt MA, Wood RJ, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. Anal Botulinum Toxin in Children with Hirschsprung Disease and Functional Constipation: A Prospective Cohort study. Eur J Pediatr Surg. 2022 Jul 19;  

                


                  Baaleman DF, Vriesman MH, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL, Koppen IJN. Do we need an extra dimension? A pilot study on the use of three-dimensional anorectal manometry in children with functional constipation. Neurogastroenterol Motil. 2022 Apr 4;  e14370.

                


                  Baaleman DF, Vriesman MH, Koppen IJN, Osborne KM, Benninga MA, Saps M, Yacob D, Lu PL, Woodley FW, Lorenzo CD. Hypnosis to Reduce Distress in Children Undergoing Anorectal Manometry: A Randomized Controlled Pilot Trial. J Neurogastroenterol Motil. 2022 Apr 30; 28: 312-319.

                


                  Di Lorenzo C. Functional Nausea Is Real and Makes You Sick. Front Pediatr. 2022; 10: 848659.

                


                  Nurko S, Saps M, Kossovsky J, Zion SR, Di Lorenzo C, Vaz K, Hawthorne K, Wu R, Ciciora S, Rosen JM, Kaptchuk TJ, Kelley JM. Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial. JAMA Pediatr. 2022 Jan 31;  

                


                  Strisciuglio C, Martinelli M, Lu P, Bar Lev MR, Beinvogl B, Benninga MA, Di Lorenzo C, Fiori Nastro F, Nurko S, Pearlstein H, Rosen R, Shamir R, Staiano A. Overall Impact of Coronavirus Disease 2019 Outbreak in Children With Functional Abdominal Pain Disorders: Results From the First Pandemic Phase. J Pediatr Gastroenterol Nutr. 2021 Dec 1; 73: 689-694.

                


                  Ahmad H, Levitt MA, Yacob D, Halleran DR, Gasior AC, Di Lorenzo C, Wood RJ, Langer JC. Evaluation and Management of Persistent Problems After Surgery for Hirschsprung Disease in a Child. Curr Gastroenterol Rep. 2021 Oct 11; 23: 18.

                


                  Orsagh-Yentis DK, Ryan K, Hurwitz N, Diefenbach KA, Teich S, Mousa H, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Gastric electrical stimulation improves symptoms and need for supplemental nutrition in children with severe nausea and vomiting: A ten-year experience. Neurogastroenterol Motil. 2021 Sep; 33: e14199.

                


                  Saps M, Nurko S, Benninga MA, Di Lorenzo C, Garza JM, Thapar N, Richards K, Lee JJ, Altepeter T. A Collaborative Effort to Advance Drug Development in Pediatric Constipation and Irritable Bowel Syndrome. J Pediatr Gastroenterol Nutr. 2021 Aug 1; 73: 145-149.

                


                  Madani S, Madani R, Parikh S, Manivannan A, Orellana WR, Thomas R, Di Lorenzo C. Symptomatic Treatment of Pain-Related Pediatric Functional Gastrointestinal Disorders in a Biopsychosocial Construct, and a Validity Study of Rome III Criteria. Clin Pediatr (Phila). 2021 Jun; 60: 304-313.

                


                  Baaleman DF, Gupta S, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The Use of Linaclotide in Children with Functional Constipation or Irritable Bowel Syndrome: A Retrospective Chart Review. Paediatr Drugs. 2021 May; 23: 307-314.

                


                  Abdulkader ZM, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Predictors of Hospital Admission for Pediatric Cyclic Vomiting Syndrome. J Pediatr. 2021 May; 232: 154-158.

                


                  Benninga MA, Hussain SZ, Sood MR, Nurko S, Hyman P, Clifford RA, O'Gorman M, Losch-Beridon T, Mareya S, Lichtlen P, Di Lorenzo C. Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-Blind Study With Long-term Extension. Clin Gastroenterol Hepatol. 2021 Apr 7;  

                


                  Seilhamer C, Di Lorenzo C, Holstine J, Samora JB. Creating a bowel management plan for pediatric orthopaedic spine surgery patients. Spine Deform. 2021 Mar; 9: 365-371.

                


                  Elfar W, Gurjar AA, Talukder MAH, Noble M, Di Lorenzo C, Elfar J. Erythropoietin promotes functional recovery in a mouse model of postoperative ileus. Neurogastroenterol Motil. 2021 Feb; 33: e14049.

                


                  Khlevner J, Rosen R, Ambartsumyan L, Lusman SS, Rosen JM, Yacob D, Mousa H, Nurko S, Di Lorenzo C, Boruta M, Ratcliffe EM, Feinstein L, Snyder J, Wood RJ, Graham K, Saps M, Gyawali CP, Rodriguez L, Belkind-Gerson J. Development of Entrustable Professional Activities and Standards in Training in Pediatric Neurogastroenterology and Motility: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and American Neurogastroenterology and Motility Society Position Paper. J Pediatr Gastroenterol Nutr. 2021 Jan 1; 72: 168-180.

                


                  Yacob D, Kroon Van Diest AM, Di Lorenzo C. Functional abdominal pain in adolescents: case-based management. Frontline Gastroenterol. 2021; 12: 629-635.

                


                  Baaleman DF, Malamisura M, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The not-so-rare absent RAIR: Internal anal sphincter achalasia in a review of 1072 children with constipation undergoing high-resolution anorectal manometry. Neurogastroenterol Motil. 2020 Dec 10;  e14028.

                


                  Jadcherla SR, Hasenstab KA, Wei L, Osborn EK, Viswanathan S, Gulati IK, Slaughter JL, Di Lorenzo C. Role of feeding strategy bundle with acid-suppressive therapy in infants with esophageal acid reflux exposure: a randomized controlled trial. Pediatr Res. 2020 May 7;  

                


                  Jadcherla SR, Sultana Z, Hasenstab-Kenney KA, Prabhakar V, Gulati IK, Di Lorenzo C. Differentiating esophageal sensitivity phenotypes using pH-impedance in intensive care unit infants referred for gastroesophageal reflux symptoms. Pediatr Res. 2020 May 6;  

                


                  Di Lorenzo C. Gastroparesis in children: Paralysis for the child or the provider? Neurogastroenterol Motil. 2020 Mar; 32: e13792.

                


                  Chumpitazi BP, Lewis J, Cooper D, D'Amato M, Lim J, Gupta S, Miranda A, Terry N, Mehta D, Scheimann A, O'Gorman M, Tipnis N, Davies Y, Friedlander J, Smith H, Punati J, Khlevner J, Setty M, Di Lorenzo C. Hypomorphic SI genetic variants are associated with childhood chronic loose stools. PLoS One. 2020; 15: e0231891.

                


                  Halleran DR, Lu PL, Ahmad H, Paradiso MM, Lehmkuhl H, Akers A, Hallagan A, Bali N, Vaz K, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. Anal sphincter botulinum toxin injection in children with functional anorectal and colonic disorders: A large institutional study and review of the literature focusing on complications. J Pediatr Surg. 2019 Nov; 54: 2305-2310.

                


                  Corsetti M, Costa M, Bassotti G, Bharucha AE, Borrelli O, Dinning P, Di Lorenzo C, Huizinga JD, Jimenez M, Rao S, Spiller R, Spencer NJ, Lentle R, Pannemans J, Thys A, Benninga M, Tack J. First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nat Rev Gastroenterol Hepatol. 2019 Jul 11;  

                


                  Di Lorenzo C, Nurko S. It's Ok to be Negative! J Pediatr Gastroenterol Nutr. 2019 Jun 17;  

                


                  Murray HB, Juarascio AS, Di Lorenzo C, Drossman DA, Thomas JJ. Diagnosis and Treatment of Rumination Syndrome: A Critical Review. Am J Gastroenterol. 2019 Apr; 114: 562-578.

                


                  Vilanova-Sanchez A, Halleran DR, Reck-Burneo CA, Gasior AC, Weaver L, Fisher M, Wagner A, Nash O, Booth K, Peters K, Williams C, Brown SM, Lu P, Fuchs M, Diefenbach K, Leonard JR, Hewitt G, McCracken K, Di Lorenzo C, Wood RJ, Levitt MA. A descriptive model for a multidisciplinary unit for colorectal and pelvic malformations. J Pediatr Surg. 2019 Mar; 54: 479-485.

                


                  Di Lorenzo C. 2018 Harry Shwachman Award. J Pediatr Gastroenterol Nutr. 2019 Mar; 68: 291.

                


                  Halleran DR, Vilanova-Sanchez A, Rentea RM, Vriesman MH, Maloof T, Lu PL, Onwuka A, Weaver L, Vaz KK, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. A comparison of Malone appendicostomy and cecostomy for antegrade access as adjuncts to a bowel management program for patients with functional constipation or fecal incontinence. J Pediatr Surg. 2019 Jan; 54: 123-128.

                


                  Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ. Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference. Gastroenterology. 2018 Sep 6;  

                


                  Gasior A, Reck C, Vilanova-Sanchez A, Diefenbach KA, Yacob D, Lu P, Vaz K, Di Lorenzo C, Levitt MA, Wood RJ. Surgical management of functional constipation: An intermediate report of a new approach using a laparoscopic sigmoid resection combined with malone appendicostomy. J Pediatr Surg. 2018 Jun; 53: 1160-1162.

                


                  Thapar N, Saliakellis E, Benninga MA, Borrelli O, Curry J, Faure C, De Giorgio R, Gupte G, Knowles CH, Staiano A, Vandenplas Y, Di Lorenzo C. Paediatric Intestinal Pseudo-obstruction: Evidence and Consensus-based Recommendations From an ESPGHAN-Led Expert Group. J Pediatr Gastroenterol Nutr. 2018 Jun; 66: 991-1019.

                


                  Saps M, Lavigne JV, van Tilburg MA, Miranda A, Benninga MA, Taminiau JA, Di Lorenzo C. Endpoints, reliability, and meaningful changes in clinical trials for children with irritable bowel syndrome. The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 May; 30: e13308.

                


                  Koppen IJN, Vriesman MH, Tabbers MM, Di Lorenzo C, Benninga MA. Awareness and Implementation of the 2014 ESPGHAN/NASPGHAN Guideline for Childhood Functional Constipation. J Pediatr Gastroenterol Nutr. 2018 May; 66: 732-737.

                


                  Di Lorenzo C. 2017 NASPGHAN Distinguished Service Award. J Pediatr Gastroenterol Nutr. 2018 May; 66: 713-714.

                


                  Koppen IJN, Vriesman MH, Saps M, Rajindrajith S, Shi X, van Etten-Jamaludin FS, Di Lorenzo C, Benninga MA, Tabbers MM. Prevalence of Functional Defecation Disorders in Children: A Systematic Review and Meta-Analysis. J Pediatr. 2018 Apr 12;  

                


                  Koppen IJN, Saps M, Lavigne JV, Nurko S, Taminiau JAJM, Di Lorenzo C, Benninga MA. Recommendations for pharmacological clinical trials in children with functional constipation: The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 Apr; 30: e13294.

                


                  Williams KC, Rogers LK, Hill I, Barnard J, Di Lorenzo C. PEG 3350 Administration Is Not Associated with Sustained Elevation of Glycol Levels. J Pediatr. 2018 Apr; 195: 148-153.e1.

                


                  Robin SG, Keller C, Zwiener R, Hyman PE, Nurko S, Saps M, Di Lorenzo C, Shulman RJ, Hyams JS, Palsson O, van Tilburg MAL. Prevalence of Pediatric Functional Gastrointestinal Disorders Utilizing the Rome IV Criteria. J Pediatr. 2018 Apr; 195: 134-139.

                


                  Manini ML, Camilleri M, Grothe R, Di Lorenzo C. Application of Pyridostigmine in Pediatric Gastrointestinal Motility Disorders: A Case Series. Paediatr Drugs. 2018 Apr; 20: 173-180.

                


                  Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, Gupta S, Langendam M, Staiano A, Thapar N, Tipnis N, Tabbers M. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2018 Mar; 66: 516-554.

                


                  Chang L, Di Lorenzo C, Farrugia G, Hamilton FA, Mawe GM, Pasricha PJ, Wiley JW. Functional Bowel Disorders: A Roadmap to Guide the Next Generation of Research. Gastroenterology. 2018 Feb; 154: 723-735.

                


                  Lu PL, Koppen IJN, Orsagh-Yentis DK, Leonhart K, Ambeba EJ, Deans KJ, Minneci PC, Teich S, Diefenbach KA, Alpert SA, Benninga MA, Yacob D, Di Lorenzo C. Sacral nerve stimulation for constipation and fecal incontinence in children: Long-term outcomes, patient benefit, and parent satisfaction. Neurogastroenterol Motil. 2018 Feb; 30: 

                


                  Kuizenga-Wessel S, Koppen IJN, Vriesman MH, Di Lorenzo C, van Dijk M, Beelen MLR, Groeneweg M, Stoffelsen RJ, Benninga MA. Attention Deficit Hyperactivity Disorder and Functional Defecation Disorders in Children. J Pediatr Gastroenterol Nutr. 2018 Feb; 66: 244-249.

                


                  Alioto A, Di Lorenzo C. Long-term Follow-up of Adolescents Treated for Rumination Syndrome in an Inpatient Setting. J Pediatr Gastroenterol Nutr. 2018 Jan; 66: 21-25.

                


                  Vriesman MH, Velasco-Benitez CA, Ramirez CR, Benninga MA, Di Lorenzo C, Saps M. Assessing Children's Report of Stool Consistency: Agreement Between the Pediatric Rome III Questionnaire and the Bristol Stool Scale. J Pediatr. 2017 Nov; 190: 69-73.

                


                  Koppen IJN, Thompson BP, Ambeba EJ, Lane VA, Bates DG, Minneci PC, Deans KJ, Levitt MA, Wood RJ, Benninga MA, Di Lorenzo C, Yacob D. Segmental colonic dilation is associated with premature termination of high-amplitude propagating contractions in children with intractable functional constipation. Neurogastroenterol Motil. 2017 Oct; 29: 1-9.

                


                  Woodley FW, Moore-Clingenpeel M, Machado RS, Nemastil CJ, Jadcherla SR, Hayes D Jr, Kopp BT, Kaul A, Di Lorenzo C, Mousa H. Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux. Pediatr Gastroenterol Hepatol Nutr. 2017 Sep; 20: 153-159.

                


                  Alioto A, Di Lorenzo C, Montgomery ML, Yacob D. High Cost and Low Yield: The Diagnostic Evaluation of Rumination Syndrome in Pediatrics. J Pediatr. 2017 Jun; 185: 155-159.

                


                  Kuizenga-Wessel S, Koppen IJN, Zwager LW, Di Lorenzo C, de Jong JR, Benninga MA. Surgical management of children with intractable functional constipation; experience of a single tertiary children's hospital. Neurogastroenterol Motil. 2017 May; 29: 

                


                  Lu PL, Asti L, Lodwick DL, Nacion KM, Deans KJ, Minneci PC, Teich S, Alpert SA, Yacob D, Di Lorenzo C, Mousa HM. Sacral nerve stimulation allows for decreased antegrade continence enema use in children with severe constipation. J Pediatr Surg. 2017 Apr; 52: 558-562.

                


                  Vandenplas Y, Szajewska H, Benninga M, Di Lorenzo C, Dupont C, Faure C, Miqdadi M, Osatakul S, Ribes-Konickx C, Saps M, Shamir R, Staiano A, BITSS Study Group.. Development of the Brussels Infant and Toddler Stool Scale ('BITSS'): protocol of the study. BMJ Open. 2017 Mar 29; 7: e014620.

                


                  Koppen IJ, Yacob D, Di Lorenzo C, Saps M, Benninga MA, Cooper JN, Minneci PC, Deans KJ, Bates DG, Thompson BP. Assessing colonic anatomy normal values based on air contrast enemas in children younger than 6 years. Pediatr Radiol. 2017 Mar; 47: 306-312.

                


                  Peeters B, Vriesman MH, Koppen IJN, van Dijk M, Grootenhuis MA, Di Lorenzo C, Benninga MA. Parental characteristics and functional constipation in children: a cross-sectional cohort study. BMJ Paediatr Open. 2017; 1: e000100.

View More Publications

Research

Publications

                  Hawa K, Janse S, Lee J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Providing a Constipation Action Plan to Families of Children With Constipation Decreases Health Care Utilization. J Pediatr Gastroenterol Nutr. 2022 Nov 1; 75: 589-594.

                


                  Hawa K, Lu PL, Holzmacher M, Wall J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Van Diest AK. INTENSIVE OUTPATIENT TREATMENT OF PEDIATRIC RUMINATION SYNDROME IN THE ERA OF TELEMEDICINE. J Pediatr Gastroenterol Nutr. 2022 Jul 28;  

                


                  Baaleman DF, Hallagan A, Halleran DR, Orsagh-Yentis DK, Levitt MA, Wood RJ, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. Anal Botulinum Toxin in Children with Hirschsprung Disease and Functional Constipation: A Prospective Cohort study. Eur J Pediatr Surg. 2022 Jul 19;  

                


                  Baaleman DF, Vriesman MH, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL, Koppen IJN. Do we need an extra dimension? A pilot study on the use of three-dimensional anorectal manometry in children with functional constipation. Neurogastroenterol Motil. 2022 Apr 4;  e14370.

                


                  Baaleman DF, Vriesman MH, Koppen IJN, Osborne KM, Benninga MA, Saps M, Yacob D, Lu PL, Woodley FW, Lorenzo CD. Hypnosis to Reduce Distress in Children Undergoing Anorectal Manometry: A Randomized Controlled Pilot Trial. J Neurogastroenterol Motil. 2022 Apr 30; 28: 312-319.

                


                  Di Lorenzo C. Functional Nausea Is Real and Makes You Sick. Front Pediatr. 2022; 10: 848659.

                


                  Nurko S, Saps M, Kossovsky J, Zion SR, Di Lorenzo C, Vaz K, Hawthorne K, Wu R, Ciciora S, Rosen JM, Kaptchuk TJ, Kelley JM. Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial. JAMA Pediatr. 2022 Jan 31;  

                


                  Strisciuglio C, Martinelli M, Lu P, Bar Lev MR, Beinvogl B, Benninga MA, Di Lorenzo C, Fiori Nastro F, Nurko S, Pearlstein H, Rosen R, Shamir R, Staiano A. Overall Impact of Coronavirus Disease 2019 Outbreak in Children With Functional Abdominal Pain Disorders: Results From the First Pandemic Phase. J Pediatr Gastroenterol Nutr. 2021 Dec 1; 73: 689-694.

                


                  Ahmad H, Levitt MA, Yacob D, Halleran DR, Gasior AC, Di Lorenzo C, Wood RJ, Langer JC. Evaluation and Management of Persistent Problems After Surgery for Hirschsprung Disease in a Child. Curr Gastroenterol Rep. 2021 Oct 11; 23: 18.

                


                  Orsagh-Yentis DK, Ryan K, Hurwitz N, Diefenbach KA, Teich S, Mousa H, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Gastric electrical stimulation improves symptoms and need for supplemental nutrition in children with severe nausea and vomiting: A ten-year experience. Neurogastroenterol Motil. 2021 Sep; 33: e14199.

                


                  Saps M, Nurko S, Benninga MA, Di Lorenzo C, Garza JM, Thapar N, Richards K, Lee JJ, Altepeter T. A Collaborative Effort to Advance Drug Development in Pediatric Constipation and Irritable Bowel Syndrome. J Pediatr Gastroenterol Nutr. 2021 Aug 1; 73: 145-149.

                


                  Madani S, Madani R, Parikh S, Manivannan A, Orellana WR, Thomas R, Di Lorenzo C. Symptomatic Treatment of Pain-Related Pediatric Functional Gastrointestinal Disorders in a Biopsychosocial Construct, and a Validity Study of Rome III Criteria. Clin Pediatr (Phila). 2021 Jun; 60: 304-313.

                


                  Baaleman DF, Gupta S, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The Use of Linaclotide in Children with Functional Constipation or Irritable Bowel Syndrome: A Retrospective Chart Review. Paediatr Drugs. 2021 May; 23: 307-314.

                


                  Abdulkader ZM, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Predictors of Hospital Admission for Pediatric Cyclic Vomiting Syndrome. J Pediatr. 2021 May; 232: 154-158.

                


                  Benninga MA, Hussain SZ, Sood MR, Nurko S, Hyman P, Clifford RA, O'Gorman M, Losch-Beridon T, Mareya S, Lichtlen P, Di Lorenzo C. Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-Blind Study With Long-term Extension. Clin Gastroenterol Hepatol. 2021 Apr 7;  

                


                  Seilhamer C, Di Lorenzo C, Holstine J, Samora JB. Creating a bowel management plan for pediatric orthopaedic spine surgery patients. Spine Deform. 2021 Mar; 9: 365-371.

                


                  Elfar W, Gurjar AA, Talukder MAH, Noble M, Di Lorenzo C, Elfar J. Erythropoietin promotes functional recovery in a mouse model of postoperative ileus. Neurogastroenterol Motil. 2021 Feb; 33: e14049.

                


                  Khlevner J, Rosen R, Ambartsumyan L, Lusman SS, Rosen JM, Yacob D, Mousa H, Nurko S, Di Lorenzo C, Boruta M, Ratcliffe EM, Feinstein L, Snyder J, Wood RJ, Graham K, Saps M, Gyawali CP, Rodriguez L, Belkind-Gerson J. Development of Entrustable Professional Activities and Standards in Training in Pediatric Neurogastroenterology and Motility: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and American Neurogastroenterology and Motility Society Position Paper. J Pediatr Gastroenterol Nutr. 2021 Jan 1; 72: 168-180.

                


                  Yacob D, Kroon Van Diest AM, Di Lorenzo C. Functional abdominal pain in adolescents: case-based management. Frontline Gastroenterol. 2021; 12: 629-635.

                


                  Baaleman DF, Malamisura M, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The not-so-rare absent RAIR: Internal anal sphincter achalasia in a review of 1072 children with constipation undergoing high-resolution anorectal manometry. Neurogastroenterol Motil. 2020 Dec 10;  e14028.

                


                  Jadcherla SR, Hasenstab KA, Wei L, Osborn EK, Viswanathan S, Gulati IK, Slaughter JL, Di Lorenzo C. Role of feeding strategy bundle with acid-suppressive therapy in infants with esophageal acid reflux exposure: a randomized controlled trial. Pediatr Res. 2020 May 7;  

                


                  Jadcherla SR, Sultana Z, Hasenstab-Kenney KA, Prabhakar V, Gulati IK, Di Lorenzo C. Differentiating esophageal sensitivity phenotypes using pH-impedance in intensive care unit infants referred for gastroesophageal reflux symptoms. Pediatr Res. 2020 May 6;  

                


                  Di Lorenzo C. Gastroparesis in children: Paralysis for the child or the provider? Neurogastroenterol Motil. 2020 Mar; 32: e13792.

                


                  Chumpitazi BP, Lewis J, Cooper D, D'Amato M, Lim J, Gupta S, Miranda A, Terry N, Mehta D, Scheimann A, O'Gorman M, Tipnis N, Davies Y, Friedlander J, Smith H, Punati J, Khlevner J, Setty M, Di Lorenzo C. Hypomorphic SI genetic variants are associated with childhood chronic loose stools. PLoS One. 2020; 15: e0231891.

                


                  Halleran DR, Lu PL, Ahmad H, Paradiso MM, Lehmkuhl H, Akers A, Hallagan A, Bali N, Vaz K, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. Anal sphincter botulinum toxin injection in children with functional anorectal and colonic disorders: A large institutional study and review of the literature focusing on complications. J Pediatr Surg. 2019 Nov; 54: 2305-2310.

                


                  Corsetti M, Costa M, Bassotti G, Bharucha AE, Borrelli O, Dinning P, Di Lorenzo C, Huizinga JD, Jimenez M, Rao S, Spiller R, Spencer NJ, Lentle R, Pannemans J, Thys A, Benninga M, Tack J. First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nat Rev Gastroenterol Hepatol. 2019 Jul 11;  

                


                  Di Lorenzo C, Nurko S. It's Ok to be Negative! J Pediatr Gastroenterol Nutr. 2019 Jun 17;  

                


                  Murray HB, Juarascio AS, Di Lorenzo C, Drossman DA, Thomas JJ. Diagnosis and Treatment of Rumination Syndrome: A Critical Review. Am J Gastroenterol. 2019 Apr; 114: 562-578.

                


                  Vilanova-Sanchez A, Halleran DR, Reck-Burneo CA, Gasior AC, Weaver L, Fisher M, Wagner A, Nash O, Booth K, Peters K, Williams C, Brown SM, Lu P, Fuchs M, Diefenbach K, Leonard JR, Hewitt G, McCracken K, Di Lorenzo C, Wood RJ, Levitt MA. A descriptive model for a multidisciplinary unit for colorectal and pelvic malformations. J Pediatr Surg. 2019 Mar; 54: 479-485.

                


                  Di Lorenzo C. 2018 Harry Shwachman Award. J Pediatr Gastroenterol Nutr. 2019 Mar; 68: 291.

                


                  Halleran DR, Vilanova-Sanchez A, Rentea RM, Vriesman MH, Maloof T, Lu PL, Onwuka A, Weaver L, Vaz KK, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. A comparison of Malone appendicostomy and cecostomy for antegrade access as adjuncts to a bowel management program for patients with functional constipation or fecal incontinence. J Pediatr Surg. 2019 Jan; 54: 123-128.

                


                  Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ. Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference. Gastroenterology. 2018 Sep 6;  

                


                  Gasior A, Reck C, Vilanova-Sanchez A, Diefenbach KA, Yacob D, Lu P, Vaz K, Di Lorenzo C, Levitt MA, Wood RJ. Surgical management of functional constipation: An intermediate report of a new approach using a laparoscopic sigmoid resection combined with malone appendicostomy. J Pediatr Surg. 2018 Jun; 53: 1160-1162.

                


                  Thapar N, Saliakellis E, Benninga MA, Borrelli O, Curry J, Faure C, De Giorgio R, Gupte G, Knowles CH, Staiano A, Vandenplas Y, Di Lorenzo C. Paediatric Intestinal Pseudo-obstruction: Evidence and Consensus-based Recommendations From an ESPGHAN-Led Expert Group. J Pediatr Gastroenterol Nutr. 2018 Jun; 66: 991-1019.

                


                  Saps M, Lavigne JV, van Tilburg MA, Miranda A, Benninga MA, Taminiau JA, Di Lorenzo C. Endpoints, reliability, and meaningful changes in clinical trials for children with irritable bowel syndrome. The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 May; 30: e13308.

                


                  Koppen IJN, Vriesman MH, Tabbers MM, Di Lorenzo C, Benninga MA. Awareness and Implementation of the 2014 ESPGHAN/NASPGHAN Guideline for Childhood Functional Constipation. J Pediatr Gastroenterol Nutr. 2018 May; 66: 732-737.

                


                  Di Lorenzo C. 2017 NASPGHAN Distinguished Service Award. J Pediatr Gastroenterol Nutr. 2018 May; 66: 713-714.

                


                  Koppen IJN, Vriesman MH, Saps M, Rajindrajith S, Shi X, van Etten-Jamaludin FS, Di Lorenzo C, Benninga MA, Tabbers MM. Prevalence of Functional Defecation Disorders in Children: A Systematic Review and Meta-Analysis. J Pediatr. 2018 Apr 12;  

                


                  Koppen IJN, Saps M, Lavigne JV, Nurko S, Taminiau JAJM, Di Lorenzo C, Benninga MA. Recommendations for pharmacological clinical trials in children with functional constipation: The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 Apr; 30: e13294.

                


                  Williams KC, Rogers LK, Hill I, Barnard J, Di Lorenzo C. PEG 3350 Administration Is Not Associated with Sustained Elevation of Glycol Levels. J Pediatr. 2018 Apr; 195: 148-153.e1.

                


                  Robin SG, Keller C, Zwiener R, Hyman PE, Nurko S, Saps M, Di Lorenzo C, Shulman RJ, Hyams JS, Palsson O, van Tilburg MAL. Prevalence of Pediatric Functional Gastrointestinal Disorders Utilizing the Rome IV Criteria. J Pediatr. 2018 Apr; 195: 134-139.

                


                  Manini ML, Camilleri M, Grothe R, Di Lorenzo C. Application of Pyridostigmine in Pediatric Gastrointestinal Motility Disorders: A Case Series. Paediatr Drugs. 2018 Apr; 20: 173-180.

                


                  Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, Gupta S, Langendam M, Staiano A, Thapar N, Tipnis N, Tabbers M. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2018 Mar; 66: 516-554.

                


                  Chang L, Di Lorenzo C, Farrugia G, Hamilton FA, Mawe GM, Pasricha PJ, Wiley JW. Functional Bowel Disorders: A Roadmap to Guide the Next Generation of Research. Gastroenterology. 2018 Feb; 154: 723-735.

                


                  Lu PL, Koppen IJN, Orsagh-Yentis DK, Leonhart K, Ambeba EJ, Deans KJ, Minneci PC, Teich S, Diefenbach KA, Alpert SA, Benninga MA, Yacob D, Di Lorenzo C. Sacral nerve stimulation for constipation and fecal incontinence in children: Long-term outcomes, patient benefit, and parent satisfaction. Neurogastroenterol Motil. 2018 Feb; 30: 

                


                  Kuizenga-Wessel S, Koppen IJN, Vriesman MH, Di Lorenzo C, van Dijk M, Beelen MLR, Groeneweg M, Stoffelsen RJ, Benninga MA. Attention Deficit Hyperactivity Disorder and Functional Defecation Disorders in Children. J Pediatr Gastroenterol Nutr. 2018 Feb; 66: 244-249.

                


                  Alioto A, Di Lorenzo C. Long-term Follow-up of Adolescents Treated for Rumination Syndrome in an Inpatient Setting. J Pediatr Gastroenterol Nutr. 2018 Jan; 66: 21-25.

                


                  Vriesman MH, Velasco-Benitez CA, Ramirez CR, Benninga MA, Di Lorenzo C, Saps M. Assessing Children's Report of Stool Consistency: Agreement Between the Pediatric Rome III Questionnaire and the Bristol Stool Scale. J Pediatr. 2017 Nov; 190: 69-73.

                


                  Koppen IJN, Thompson BP, Ambeba EJ, Lane VA, Bates DG, Minneci PC, Deans KJ, Levitt MA, Wood RJ, Benninga MA, Di Lorenzo C, Yacob D. Segmental colonic dilation is associated with premature termination of high-amplitude propagating contractions in children with intractable functional constipation. Neurogastroenterol Motil. 2017 Oct; 29: 1-9.

                


                  Woodley FW, Moore-Clingenpeel M, Machado RS, Nemastil CJ, Jadcherla SR, Hayes D Jr, Kopp BT, Kaul A, Di Lorenzo C, Mousa H. Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux. Pediatr Gastroenterol Hepatol Nutr. 2017 Sep; 20: 153-159.

                


                  Alioto A, Di Lorenzo C, Montgomery ML, Yacob D. High Cost and Low Yield: The Diagnostic Evaluation of Rumination Syndrome in Pediatrics. J Pediatr. 2017 Jun; 185: 155-159.

                


                  Kuizenga-Wessel S, Koppen IJN, Zwager LW, Di Lorenzo C, de Jong JR, Benninga MA. Surgical management of children with intractable functional constipation; experience of a single tertiary children's hospital. Neurogastroenterol Motil. 2017 May; 29: 

                


                  Lu PL, Asti L, Lodwick DL, Nacion KM, Deans KJ, Minneci PC, Teich S, Alpert SA, Yacob D, Di Lorenzo C, Mousa HM. Sacral nerve stimulation allows for decreased antegrade continence enema use in children with severe constipation. J Pediatr Surg. 2017 Apr; 52: 558-562.

                


                  Vandenplas Y, Szajewska H, Benninga M, Di Lorenzo C, Dupont C, Faure C, Miqdadi M, Osatakul S, Ribes-Konickx C, Saps M, Shamir R, Staiano A, BITSS Study Group.. Development of the Brussels Infant and Toddler Stool Scale ('BITSS'): protocol of the study. BMJ Open. 2017 Mar 29; 7: e014620.

                


                  Koppen IJ, Yacob D, Di Lorenzo C, Saps M, Benninga MA, Cooper JN, Minneci PC, Deans KJ, Bates DG, Thompson BP. Assessing colonic anatomy normal values based on air contrast enemas in children younger than 6 years. Pediatr Radiol. 2017 Mar; 47: 306-312.

                


                  Peeters B, Vriesman MH, Koppen IJN, van Dijk M, Grootenhuis MA, Di Lorenzo C, Benninga MA. Parental characteristics and functional constipation in children: a cross-sectional cohort study. BMJ Paediatr Open. 2017; 1: e000100.

View More Publications

Publications

                  Hawa K, Janse S, Lee J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Providing a Constipation Action Plan to Families of Children With Constipation Decreases Health Care Utilization. J Pediatr Gastroenterol Nutr. 2022 Nov 1; 75: 589-594.

                


                  Hawa K, Lu PL, Holzmacher M, Wall J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Van Diest AK. INTENSIVE OUTPATIENT TREATMENT OF PEDIATRIC RUMINATION SYNDROME IN THE ERA OF TELEMEDICINE. J Pediatr Gastroenterol Nutr. 2022 Jul 28;  

                


                  Baaleman DF, Hallagan A, Halleran DR, Orsagh-Yentis DK, Levitt MA, Wood RJ, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. Anal Botulinum Toxin in Children with Hirschsprung Disease and Functional Constipation: A Prospective Cohort study. Eur J Pediatr Surg. 2022 Jul 19;  

                


                  Baaleman DF, Vriesman MH, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL, Koppen IJN. Do we need an extra dimension? A pilot study on the use of three-dimensional anorectal manometry in children with functional constipation. Neurogastroenterol Motil. 2022 Apr 4;  e14370.

                


                  Baaleman DF, Vriesman MH, Koppen IJN, Osborne KM, Benninga MA, Saps M, Yacob D, Lu PL, Woodley FW, Lorenzo CD. Hypnosis to Reduce Distress in Children Undergoing Anorectal Manometry: A Randomized Controlled Pilot Trial. J Neurogastroenterol Motil. 2022 Apr 30; 28: 312-319.

                


                  Di Lorenzo C. Functional Nausea Is Real and Makes You Sick. Front Pediatr. 2022; 10: 848659.

                


                  Nurko S, Saps M, Kossovsky J, Zion SR, Di Lorenzo C, Vaz K, Hawthorne K, Wu R, Ciciora S, Rosen JM, Kaptchuk TJ, Kelley JM. Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial. JAMA Pediatr. 2022 Jan 31;  

                


                  Strisciuglio C, Martinelli M, Lu P, Bar Lev MR, Beinvogl B, Benninga MA, Di Lorenzo C, Fiori Nastro F, Nurko S, Pearlstein H, Rosen R, Shamir R, Staiano A. Overall Impact of Coronavirus Disease 2019 Outbreak in Children With Functional Abdominal Pain Disorders: Results From the First Pandemic Phase. J Pediatr Gastroenterol Nutr. 2021 Dec 1; 73: 689-694.

                


                  Ahmad H, Levitt MA, Yacob D, Halleran DR, Gasior AC, Di Lorenzo C, Wood RJ, Langer JC. Evaluation and Management of Persistent Problems After Surgery for Hirschsprung Disease in a Child. Curr Gastroenterol Rep. 2021 Oct 11; 23: 18.

                


                  Orsagh-Yentis DK, Ryan K, Hurwitz N, Diefenbach KA, Teich S, Mousa H, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Gastric electrical stimulation improves symptoms and need for supplemental nutrition in children with severe nausea and vomiting: A ten-year experience. Neurogastroenterol Motil. 2021 Sep; 33: e14199.

                


                  Saps M, Nurko S, Benninga MA, Di Lorenzo C, Garza JM, Thapar N, Richards K, Lee JJ, Altepeter T. A Collaborative Effort to Advance Drug Development in Pediatric Constipation and Irritable Bowel Syndrome. J Pediatr Gastroenterol Nutr. 2021 Aug 1; 73: 145-149.

                


                  Madani S, Madani R, Parikh S, Manivannan A, Orellana WR, Thomas R, Di Lorenzo C. Symptomatic Treatment of Pain-Related Pediatric Functional Gastrointestinal Disorders in a Biopsychosocial Construct, and a Validity Study of Rome III Criteria. Clin Pediatr (Phila). 2021 Jun; 60: 304-313.

                


                  Baaleman DF, Gupta S, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The Use of Linaclotide in Children with Functional Constipation or Irritable Bowel Syndrome: A Retrospective Chart Review. Paediatr Drugs. 2021 May; 23: 307-314.

                


                  Abdulkader ZM, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Predictors of Hospital Admission for Pediatric Cyclic Vomiting Syndrome. J Pediatr. 2021 May; 232: 154-158.

                


                  Benninga MA, Hussain SZ, Sood MR, Nurko S, Hyman P, Clifford RA, O'Gorman M, Losch-Beridon T, Mareya S, Lichtlen P, Di Lorenzo C. Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-Blind Study With Long-term Extension. Clin Gastroenterol Hepatol. 2021 Apr 7;  

                


                  Seilhamer C, Di Lorenzo C, Holstine J, Samora JB. Creating a bowel management plan for pediatric orthopaedic spine surgery patients. Spine Deform. 2021 Mar; 9: 365-371.

                


                  Elfar W, Gurjar AA, Talukder MAH, Noble M, Di Lorenzo C, Elfar J. Erythropoietin promotes functional recovery in a mouse model of postoperative ileus. Neurogastroenterol Motil. 2021 Feb; 33: e14049.

                


                  Khlevner J, Rosen R, Ambartsumyan L, Lusman SS, Rosen JM, Yacob D, Mousa H, Nurko S, Di Lorenzo C, Boruta M, Ratcliffe EM, Feinstein L, Snyder J, Wood RJ, Graham K, Saps M, Gyawali CP, Rodriguez L, Belkind-Gerson J. Development of Entrustable Professional Activities and Standards in Training in Pediatric Neurogastroenterology and Motility: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and American Neurogastroenterology and Motility Society Position Paper. J Pediatr Gastroenterol Nutr. 2021 Jan 1; 72: 168-180.

                


                  Yacob D, Kroon Van Diest AM, Di Lorenzo C. Functional abdominal pain in adolescents: case-based management. Frontline Gastroenterol. 2021; 12: 629-635.

                


                  Baaleman DF, Malamisura M, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The not-so-rare absent RAIR: Internal anal sphincter achalasia in a review of 1072 children with constipation undergoing high-resolution anorectal manometry. Neurogastroenterol Motil. 2020 Dec 10;  e14028.

                


                  Jadcherla SR, Hasenstab KA, Wei L, Osborn EK, Viswanathan S, Gulati IK, Slaughter JL, Di Lorenzo C. Role of feeding strategy bundle with acid-suppressive therapy in infants with esophageal acid reflux exposure: a randomized controlled trial. Pediatr Res. 2020 May 7;  

                


                  Jadcherla SR, Sultana Z, Hasenstab-Kenney KA, Prabhakar V, Gulati IK, Di Lorenzo C. Differentiating esophageal sensitivity phenotypes using pH-impedance in intensive care unit infants referred for gastroesophageal reflux symptoms. Pediatr Res. 2020 May 6;  

                


                  Di Lorenzo C. Gastroparesis in children: Paralysis for the child or the provider? Neurogastroenterol Motil. 2020 Mar; 32: e13792.

                


                  Chumpitazi BP, Lewis J, Cooper D, D'Amato M, Lim J, Gupta S, Miranda A, Terry N, Mehta D, Scheimann A, O'Gorman M, Tipnis N, Davies Y, Friedlander J, Smith H, Punati J, Khlevner J, Setty M, Di Lorenzo C. Hypomorphic SI genetic variants are associated with childhood chronic loose stools. PLoS One. 2020; 15: e0231891.

                


                  Halleran DR, Lu PL, Ahmad H, Paradiso MM, Lehmkuhl H, Akers A, Hallagan A, Bali N, Vaz K, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. Anal sphincter botulinum toxin injection in children with functional anorectal and colonic disorders: A large institutional study and review of the literature focusing on complications. J Pediatr Surg. 2019 Nov; 54: 2305-2310.

                


                  Corsetti M, Costa M, Bassotti G, Bharucha AE, Borrelli O, Dinning P, Di Lorenzo C, Huizinga JD, Jimenez M, Rao S, Spiller R, Spencer NJ, Lentle R, Pannemans J, Thys A, Benninga M, Tack J. First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nat Rev Gastroenterol Hepatol. 2019 Jul 11;  

                


                  Di Lorenzo C, Nurko S. It's Ok to be Negative! J Pediatr Gastroenterol Nutr. 2019 Jun 17;  

                


                  Murray HB, Juarascio AS, Di Lorenzo C, Drossman DA, Thomas JJ. Diagnosis and Treatment of Rumination Syndrome: A Critical Review. Am J Gastroenterol. 2019 Apr; 114: 562-578.

                


                  Vilanova-Sanchez A, Halleran DR, Reck-Burneo CA, Gasior AC, Weaver L, Fisher M, Wagner A, Nash O, Booth K, Peters K, Williams C, Brown SM, Lu P, Fuchs M, Diefenbach K, Leonard JR, Hewitt G, McCracken K, Di Lorenzo C, Wood RJ, Levitt MA. A descriptive model for a multidisciplinary unit for colorectal and pelvic malformations. J Pediatr Surg. 2019 Mar; 54: 479-485.

                


                  Di Lorenzo C. 2018 Harry Shwachman Award. J Pediatr Gastroenterol Nutr. 2019 Mar; 68: 291.

                


                  Halleran DR, Vilanova-Sanchez A, Rentea RM, Vriesman MH, Maloof T, Lu PL, Onwuka A, Weaver L, Vaz KK, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. A comparison of Malone appendicostomy and cecostomy for antegrade access as adjuncts to a bowel management program for patients with functional constipation or fecal incontinence. J Pediatr Surg. 2019 Jan; 54: 123-128.

                


                  Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ. Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference. Gastroenterology. 2018 Sep 6;  

                


                  Gasior A, Reck C, Vilanova-Sanchez A, Diefenbach KA, Yacob D, Lu P, Vaz K, Di Lorenzo C, Levitt MA, Wood RJ. Surgical management of functional constipation: An intermediate report of a new approach using a laparoscopic sigmoid resection combined with malone appendicostomy. J Pediatr Surg. 2018 Jun; 53: 1160-1162.

                


                  Thapar N, Saliakellis E, Benninga MA, Borrelli O, Curry J, Faure C, De Giorgio R, Gupte G, Knowles CH, Staiano A, Vandenplas Y, Di Lorenzo C. Paediatric Intestinal Pseudo-obstruction: Evidence and Consensus-based Recommendations From an ESPGHAN-Led Expert Group. J Pediatr Gastroenterol Nutr. 2018 Jun; 66: 991-1019.

                


                  Saps M, Lavigne JV, van Tilburg MA, Miranda A, Benninga MA, Taminiau JA, Di Lorenzo C. Endpoints, reliability, and meaningful changes in clinical trials for children with irritable bowel syndrome. The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 May; 30: e13308.

                


                  Koppen IJN, Vriesman MH, Tabbers MM, Di Lorenzo C, Benninga MA. Awareness and Implementation of the 2014 ESPGHAN/NASPGHAN Guideline for Childhood Functional Constipation. J Pediatr Gastroenterol Nutr. 2018 May; 66: 732-737.

                


                  Di Lorenzo C. 2017 NASPGHAN Distinguished Service Award. J Pediatr Gastroenterol Nutr. 2018 May; 66: 713-714.

                


                  Koppen IJN, Vriesman MH, Saps M, Rajindrajith S, Shi X, van Etten-Jamaludin FS, Di Lorenzo C, Benninga MA, Tabbers MM. Prevalence of Functional Defecation Disorders in Children: A Systematic Review and Meta-Analysis. J Pediatr. 2018 Apr 12;  

                


                  Koppen IJN, Saps M, Lavigne JV, Nurko S, Taminiau JAJM, Di Lorenzo C, Benninga MA. Recommendations for pharmacological clinical trials in children with functional constipation: The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 Apr; 30: e13294.

                


                  Williams KC, Rogers LK, Hill I, Barnard J, Di Lorenzo C. PEG 3350 Administration Is Not Associated with Sustained Elevation of Glycol Levels. J Pediatr. 2018 Apr; 195: 148-153.e1.

                


                  Robin SG, Keller C, Zwiener R, Hyman PE, Nurko S, Saps M, Di Lorenzo C, Shulman RJ, Hyams JS, Palsson O, van Tilburg MAL. Prevalence of Pediatric Functional Gastrointestinal Disorders Utilizing the Rome IV Criteria. J Pediatr. 2018 Apr; 195: 134-139.

                


                  Manini ML, Camilleri M, Grothe R, Di Lorenzo C. Application of Pyridostigmine in Pediatric Gastrointestinal Motility Disorders: A Case Series. Paediatr Drugs. 2018 Apr; 20: 173-180.

                


                  Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, Gupta S, Langendam M, Staiano A, Thapar N, Tipnis N, Tabbers M. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2018 Mar; 66: 516-554.

                


                  Chang L, Di Lorenzo C, Farrugia G, Hamilton FA, Mawe GM, Pasricha PJ, Wiley JW. Functional Bowel Disorders: A Roadmap to Guide the Next Generation of Research. Gastroenterology. 2018 Feb; 154: 723-735.

                


                  Lu PL, Koppen IJN, Orsagh-Yentis DK, Leonhart K, Ambeba EJ, Deans KJ, Minneci PC, Teich S, Diefenbach KA, Alpert SA, Benninga MA, Yacob D, Di Lorenzo C. Sacral nerve stimulation for constipation and fecal incontinence in children: Long-term outcomes, patient benefit, and parent satisfaction. Neurogastroenterol Motil. 2018 Feb; 30: 

                


                  Kuizenga-Wessel S, Koppen IJN, Vriesman MH, Di Lorenzo C, van Dijk M, Beelen MLR, Groeneweg M, Stoffelsen RJ, Benninga MA. Attention Deficit Hyperactivity Disorder and Functional Defecation Disorders in Children. J Pediatr Gastroenterol Nutr. 2018 Feb; 66: 244-249.

                


                  Alioto A, Di Lorenzo C. Long-term Follow-up of Adolescents Treated for Rumination Syndrome in an Inpatient Setting. J Pediatr Gastroenterol Nutr. 2018 Jan; 66: 21-25.

                


                  Vriesman MH, Velasco-Benitez CA, Ramirez CR, Benninga MA, Di Lorenzo C, Saps M. Assessing Children's Report of Stool Consistency: Agreement Between the Pediatric Rome III Questionnaire and the Bristol Stool Scale. J Pediatr. 2017 Nov; 190: 69-73.

                


                  Koppen IJN, Thompson BP, Ambeba EJ, Lane VA, Bates DG, Minneci PC, Deans KJ, Levitt MA, Wood RJ, Benninga MA, Di Lorenzo C, Yacob D. Segmental colonic dilation is associated with premature termination of high-amplitude propagating contractions in children with intractable functional constipation. Neurogastroenterol Motil. 2017 Oct; 29: 1-9.

                


                  Woodley FW, Moore-Clingenpeel M, Machado RS, Nemastil CJ, Jadcherla SR, Hayes D Jr, Kopp BT, Kaul A, Di Lorenzo C, Mousa H. Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux. Pediatr Gastroenterol Hepatol Nutr. 2017 Sep; 20: 153-159.

                


                  Alioto A, Di Lorenzo C, Montgomery ML, Yacob D. High Cost and Low Yield: The Diagnostic Evaluation of Rumination Syndrome in Pediatrics. J Pediatr. 2017 Jun; 185: 155-159.

                


                  Kuizenga-Wessel S, Koppen IJN, Zwager LW, Di Lorenzo C, de Jong JR, Benninga MA. Surgical management of children with intractable functional constipation; experience of a single tertiary children's hospital. Neurogastroenterol Motil. 2017 May; 29: 

                


                  Lu PL, Asti L, Lodwick DL, Nacion KM, Deans KJ, Minneci PC, Teich S, Alpert SA, Yacob D, Di Lorenzo C, Mousa HM. Sacral nerve stimulation allows for decreased antegrade continence enema use in children with severe constipation. J Pediatr Surg. 2017 Apr; 52: 558-562.

                


                  Vandenplas Y, Szajewska H, Benninga M, Di Lorenzo C, Dupont C, Faure C, Miqdadi M, Osatakul S, Ribes-Konickx C, Saps M, Shamir R, Staiano A, BITSS Study Group.. Development of the Brussels Infant and Toddler Stool Scale ('BITSS'): protocol of the study. BMJ Open. 2017 Mar 29; 7: e014620.

                


                  Koppen IJ, Yacob D, Di Lorenzo C, Saps M, Benninga MA, Cooper JN, Minneci PC, Deans KJ, Bates DG, Thompson BP. Assessing colonic anatomy normal values based on air contrast enemas in children younger than 6 years. Pediatr Radiol. 2017 Mar; 47: 306-312.

                


                  Peeters B, Vriesman MH, Koppen IJN, van Dijk M, Grootenhuis MA, Di Lorenzo C, Benninga MA. Parental characteristics and functional constipation in children: a cross-sectional cohort study. BMJ Paediatr Open. 2017; 1: e000100.

View More Publications

                  Hawa K, Janse S, Lee J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Providing a Constipation Action Plan to Families of Children With Constipation Decreases Health Care Utilization. J Pediatr Gastroenterol Nutr. 2022 Nov 1; 75: 589-594.

                


                  Hawa K, Lu PL, Holzmacher M, Wall J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Van Diest AK. INTENSIVE OUTPATIENT TREATMENT OF PEDIATRIC RUMINATION SYNDROME IN THE ERA OF TELEMEDICINE. J Pediatr Gastroenterol Nutr. 2022 Jul 28;  

                


                  Baaleman DF, Hallagan A, Halleran DR, Orsagh-Yentis DK, Levitt MA, Wood RJ, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. Anal Botulinum Toxin in Children with Hirschsprung Disease and Functional Constipation: A Prospective Cohort study. Eur J Pediatr Surg. 2022 Jul 19;  

                


                  Baaleman DF, Vriesman MH, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL, Koppen IJN. Do we need an extra dimension? A pilot study on the use of three-dimensional anorectal manometry in children with functional constipation. Neurogastroenterol Motil. 2022 Apr 4;  e14370.

                


                  Baaleman DF, Vriesman MH, Koppen IJN, Osborne KM, Benninga MA, Saps M, Yacob D, Lu PL, Woodley FW, Lorenzo CD. Hypnosis to Reduce Distress in Children Undergoing Anorectal Manometry: A Randomized Controlled Pilot Trial. J Neurogastroenterol Motil. 2022 Apr 30; 28: 312-319.

                


                  Di Lorenzo C. Functional Nausea Is Real and Makes You Sick. Front Pediatr. 2022; 10: 848659.

                


                  Nurko S, Saps M, Kossovsky J, Zion SR, Di Lorenzo C, Vaz K, Hawthorne K, Wu R, Ciciora S, Rosen JM, Kaptchuk TJ, Kelley JM. Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial. JAMA Pediatr. 2022 Jan 31;  

                


                  Strisciuglio C, Martinelli M, Lu P, Bar Lev MR, Beinvogl B, Benninga MA, Di Lorenzo C, Fiori Nastro F, Nurko S, Pearlstein H, Rosen R, Shamir R, Staiano A. Overall Impact of Coronavirus Disease 2019 Outbreak in Children With Functional Abdominal Pain Disorders: Results From the First Pandemic Phase. J Pediatr Gastroenterol Nutr. 2021 Dec 1; 73: 689-694.

                


                  Ahmad H, Levitt MA, Yacob D, Halleran DR, Gasior AC, Di Lorenzo C, Wood RJ, Langer JC. Evaluation and Management of Persistent Problems After Surgery for Hirschsprung Disease in a Child. Curr Gastroenterol Rep. 2021 Oct 11; 23: 18.

                


                  Orsagh-Yentis DK, Ryan K, Hurwitz N, Diefenbach KA, Teich S, Mousa H, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Gastric electrical stimulation improves symptoms and need for supplemental nutrition in children with severe nausea and vomiting: A ten-year experience. Neurogastroenterol Motil. 2021 Sep; 33: e14199.

                


                  Saps M, Nurko S, Benninga MA, Di Lorenzo C, Garza JM, Thapar N, Richards K, Lee JJ, Altepeter T. A Collaborative Effort to Advance Drug Development in Pediatric Constipation and Irritable Bowel Syndrome. J Pediatr Gastroenterol Nutr. 2021 Aug 1; 73: 145-149.

                


                  Madani S, Madani R, Parikh S, Manivannan A, Orellana WR, Thomas R, Di Lorenzo C. Symptomatic Treatment of Pain-Related Pediatric Functional Gastrointestinal Disorders in a Biopsychosocial Construct, and a Validity Study of Rome III Criteria. Clin Pediatr (Phila). 2021 Jun; 60: 304-313.

                


                  Baaleman DF, Gupta S, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The Use of Linaclotide in Children with Functional Constipation or Irritable Bowel Syndrome: A Retrospective Chart Review. Paediatr Drugs. 2021 May; 23: 307-314.

                


                  Abdulkader ZM, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Predictors of Hospital Admission for Pediatric Cyclic Vomiting Syndrome. J Pediatr. 2021 May; 232: 154-158.

                


                  Benninga MA, Hussain SZ, Sood MR, Nurko S, Hyman P, Clifford RA, O'Gorman M, Losch-Beridon T, Mareya S, Lichtlen P, Di Lorenzo C. Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-Blind Study With Long-term Extension. Clin Gastroenterol Hepatol. 2021 Apr 7;  

                


                  Seilhamer C, Di Lorenzo C, Holstine J, Samora JB. Creating a bowel management plan for pediatric orthopaedic spine surgery patients. Spine Deform. 2021 Mar; 9: 365-371.

                


                  Elfar W, Gurjar AA, Talukder MAH, Noble M, Di Lorenzo C, Elfar J. Erythropoietin promotes functional recovery in a mouse model of postoperative ileus. Neurogastroenterol Motil. 2021 Feb; 33: e14049.

                


                  Khlevner J, Rosen R, Ambartsumyan L, Lusman SS, Rosen JM, Yacob D, Mousa H, Nurko S, Di Lorenzo C, Boruta M, Ratcliffe EM, Feinstein L, Snyder J, Wood RJ, Graham K, Saps M, Gyawali CP, Rodriguez L, Belkind-Gerson J. Development of Entrustable Professional Activities and Standards in Training in Pediatric Neurogastroenterology and Motility: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and American Neurogastroenterology and Motility Society Position Paper. J Pediatr Gastroenterol Nutr. 2021 Jan 1; 72: 168-180.

                


                  Yacob D, Kroon Van Diest AM, Di Lorenzo C. Functional abdominal pain in adolescents: case-based management. Frontline Gastroenterol. 2021; 12: 629-635.

                


                  Baaleman DF, Malamisura M, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The not-so-rare absent RAIR: Internal anal sphincter achalasia in a review of 1072 children with constipation undergoing high-resolution anorectal manometry. Neurogastroenterol Motil. 2020 Dec 10;  e14028.

                


                  Jadcherla SR, Hasenstab KA, Wei L, Osborn EK, Viswanathan S, Gulati IK, Slaughter JL, Di Lorenzo C. Role of feeding strategy bundle with acid-suppressive therapy in infants with esophageal acid reflux exposure: a randomized controlled trial. Pediatr Res. 2020 May 7;  

                


                  Jadcherla SR, Sultana Z, Hasenstab-Kenney KA, Prabhakar V, Gulati IK, Di Lorenzo C. Differentiating esophageal sensitivity phenotypes using pH-impedance in intensive care unit infants referred for gastroesophageal reflux symptoms. Pediatr Res. 2020 May 6;  

                


                  Di Lorenzo C. Gastroparesis in children: Paralysis for the child or the provider? Neurogastroenterol Motil. 2020 Mar; 32: e13792.

                


                  Chumpitazi BP, Lewis J, Cooper D, D'Amato M, Lim J, Gupta S, Miranda A, Terry N, Mehta D, Scheimann A, O'Gorman M, Tipnis N, Davies Y, Friedlander J, Smith H, Punati J, Khlevner J, Setty M, Di Lorenzo C. Hypomorphic SI genetic variants are associated with childhood chronic loose stools. PLoS One. 2020; 15: e0231891.

                


                  Halleran DR, Lu PL, Ahmad H, Paradiso MM, Lehmkuhl H, Akers A, Hallagan A, Bali N, Vaz K, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. Anal sphincter botulinum toxin injection in children with functional anorectal and colonic disorders: A large institutional study and review of the literature focusing on complications. J Pediatr Surg. 2019 Nov; 54: 2305-2310.

                


                  Corsetti M, Costa M, Bassotti G, Bharucha AE, Borrelli O, Dinning P, Di Lorenzo C, Huizinga JD, Jimenez M, Rao S, Spiller R, Spencer NJ, Lentle R, Pannemans J, Thys A, Benninga M, Tack J. First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nat Rev Gastroenterol Hepatol. 2019 Jul 11;  

                


                  Di Lorenzo C, Nurko S. It's Ok to be Negative! J Pediatr Gastroenterol Nutr. 2019 Jun 17;  

                


                  Murray HB, Juarascio AS, Di Lorenzo C, Drossman DA, Thomas JJ. Diagnosis and Treatment of Rumination Syndrome: A Critical Review. Am J Gastroenterol. 2019 Apr; 114: 562-578.

                


                  Vilanova-Sanchez A, Halleran DR, Reck-Burneo CA, Gasior AC, Weaver L, Fisher M, Wagner A, Nash O, Booth K, Peters K, Williams C, Brown SM, Lu P, Fuchs M, Diefenbach K, Leonard JR, Hewitt G, McCracken K, Di Lorenzo C, Wood RJ, Levitt MA. A descriptive model for a multidisciplinary unit for colorectal and pelvic malformations. J Pediatr Surg. 2019 Mar; 54: 479-485.

                


                  Di Lorenzo C. 2018 Harry Shwachman Award. J Pediatr Gastroenterol Nutr. 2019 Mar; 68: 291.

                


                  Halleran DR, Vilanova-Sanchez A, Rentea RM, Vriesman MH, Maloof T, Lu PL, Onwuka A, Weaver L, Vaz KK, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. A comparison of Malone appendicostomy and cecostomy for antegrade access as adjuncts to a bowel management program for patients with functional constipation or fecal incontinence. J Pediatr Surg. 2019 Jan; 54: 123-128.

                


                  Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ. Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference. Gastroenterology. 2018 Sep 6;  

                


                  Gasior A, Reck C, Vilanova-Sanchez A, Diefenbach KA, Yacob D, Lu P, Vaz K, Di Lorenzo C, Levitt MA, Wood RJ. Surgical management of functional constipation: An intermediate report of a new approach using a laparoscopic sigmoid resection combined with malone appendicostomy. J Pediatr Surg. 2018 Jun; 53: 1160-1162.

                


                  Thapar N, Saliakellis E, Benninga MA, Borrelli O, Curry J, Faure C, De Giorgio R, Gupte G, Knowles CH, Staiano A, Vandenplas Y, Di Lorenzo C. Paediatric Intestinal Pseudo-obstruction: Evidence and Consensus-based Recommendations From an ESPGHAN-Led Expert Group. J Pediatr Gastroenterol Nutr. 2018 Jun; 66: 991-1019.

                


                  Saps M, Lavigne JV, van Tilburg MA, Miranda A, Benninga MA, Taminiau JA, Di Lorenzo C. Endpoints, reliability, and meaningful changes in clinical trials for children with irritable bowel syndrome. The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 May; 30: e13308.

                


                  Koppen IJN, Vriesman MH, Tabbers MM, Di Lorenzo C, Benninga MA. Awareness and Implementation of the 2014 ESPGHAN/NASPGHAN Guideline for Childhood Functional Constipation. J Pediatr Gastroenterol Nutr. 2018 May; 66: 732-737.

                


                  Di Lorenzo C. 2017 NASPGHAN Distinguished Service Award. J Pediatr Gastroenterol Nutr. 2018 May; 66: 713-714.

                


                  Koppen IJN, Vriesman MH, Saps M, Rajindrajith S, Shi X, van Etten-Jamaludin FS, Di Lorenzo C, Benninga MA, Tabbers MM. Prevalence of Functional Defecation Disorders in Children: A Systematic Review and Meta-Analysis. J Pediatr. 2018 Apr 12;  

                


                  Koppen IJN, Saps M, Lavigne JV, Nurko S, Taminiau JAJM, Di Lorenzo C, Benninga MA. Recommendations for pharmacological clinical trials in children with functional constipation: The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 Apr; 30: e13294.

                


                  Williams KC, Rogers LK, Hill I, Barnard J, Di Lorenzo C. PEG 3350 Administration Is Not Associated with Sustained Elevation of Glycol Levels. J Pediatr. 2018 Apr; 195: 148-153.e1.

                


                  Robin SG, Keller C, Zwiener R, Hyman PE, Nurko S, Saps M, Di Lorenzo C, Shulman RJ, Hyams JS, Palsson O, van Tilburg MAL. Prevalence of Pediatric Functional Gastrointestinal Disorders Utilizing the Rome IV Criteria. J Pediatr. 2018 Apr; 195: 134-139.

                


                  Manini ML, Camilleri M, Grothe R, Di Lorenzo C. Application of Pyridostigmine in Pediatric Gastrointestinal Motility Disorders: A Case Series. Paediatr Drugs. 2018 Apr; 20: 173-180.

                


                  Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, Gupta S, Langendam M, Staiano A, Thapar N, Tipnis N, Tabbers M. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2018 Mar; 66: 516-554.

                


                  Chang L, Di Lorenzo C, Farrugia G, Hamilton FA, Mawe GM, Pasricha PJ, Wiley JW. Functional Bowel Disorders: A Roadmap to Guide the Next Generation of Research. Gastroenterology. 2018 Feb; 154: 723-735.

                


                  Lu PL, Koppen IJN, Orsagh-Yentis DK, Leonhart K, Ambeba EJ, Deans KJ, Minneci PC, Teich S, Diefenbach KA, Alpert SA, Benninga MA, Yacob D, Di Lorenzo C. Sacral nerve stimulation for constipation and fecal incontinence in children: Long-term outcomes, patient benefit, and parent satisfaction. Neurogastroenterol Motil. 2018 Feb; 30: 

                


                  Kuizenga-Wessel S, Koppen IJN, Vriesman MH, Di Lorenzo C, van Dijk M, Beelen MLR, Groeneweg M, Stoffelsen RJ, Benninga MA. Attention Deficit Hyperactivity Disorder and Functional Defecation Disorders in Children. J Pediatr Gastroenterol Nutr. 2018 Feb; 66: 244-249.

                


                  Alioto A, Di Lorenzo C. Long-term Follow-up of Adolescents Treated for Rumination Syndrome in an Inpatient Setting. J Pediatr Gastroenterol Nutr. 2018 Jan; 66: 21-25.

                


                  Vriesman MH, Velasco-Benitez CA, Ramirez CR, Benninga MA, Di Lorenzo C, Saps M. Assessing Children's Report of Stool Consistency: Agreement Between the Pediatric Rome III Questionnaire and the Bristol Stool Scale. J Pediatr. 2017 Nov; 190: 69-73.

                


                  Koppen IJN, Thompson BP, Ambeba EJ, Lane VA, Bates DG, Minneci PC, Deans KJ, Levitt MA, Wood RJ, Benninga MA, Di Lorenzo C, Yacob D. Segmental colonic dilation is associated with premature termination of high-amplitude propagating contractions in children with intractable functional constipation. Neurogastroenterol Motil. 2017 Oct; 29: 1-9.

                


                  Woodley FW, Moore-Clingenpeel M, Machado RS, Nemastil CJ, Jadcherla SR, Hayes D Jr, Kopp BT, Kaul A, Di Lorenzo C, Mousa H. Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux. Pediatr Gastroenterol Hepatol Nutr. 2017 Sep; 20: 153-159.

                


                  Alioto A, Di Lorenzo C, Montgomery ML, Yacob D. High Cost and Low Yield: The Diagnostic Evaluation of Rumination Syndrome in Pediatrics. J Pediatr. 2017 Jun; 185: 155-159.

                


                  Kuizenga-Wessel S, Koppen IJN, Zwager LW, Di Lorenzo C, de Jong JR, Benninga MA. Surgical management of children with intractable functional constipation; experience of a single tertiary children's hospital. Neurogastroenterol Motil. 2017 May; 29: 

                


                  Lu PL, Asti L, Lodwick DL, Nacion KM, Deans KJ, Minneci PC, Teich S, Alpert SA, Yacob D, Di Lorenzo C, Mousa HM. Sacral nerve stimulation allows for decreased antegrade continence enema use in children with severe constipation. J Pediatr Surg. 2017 Apr; 52: 558-562.

                


                  Vandenplas Y, Szajewska H, Benninga M, Di Lorenzo C, Dupont C, Faure C, Miqdadi M, Osatakul S, Ribes-Konickx C, Saps M, Shamir R, Staiano A, BITSS Study Group.. Development of the Brussels Infant and Toddler Stool Scale ('BITSS'): protocol of the study. BMJ Open. 2017 Mar 29; 7: e014620.

                


                  Koppen IJ, Yacob D, Di Lorenzo C, Saps M, Benninga MA, Cooper JN, Minneci PC, Deans KJ, Bates DG, Thompson BP. Assessing colonic anatomy normal values based on air contrast enemas in children younger than 6 years. Pediatr Radiol. 2017 Mar; 47: 306-312.

                


                  Peeters B, Vriesman MH, Koppen IJN, van Dijk M, Grootenhuis MA, Di Lorenzo C, Benninga MA. Parental characteristics and functional constipation in children: a cross-sectional cohort study. BMJ Paediatr Open. 2017; 1: e000100.

View More Publications

• Hawa K, Janse S, Lee J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Providing a Constipation Action Plan to Families of Children With Constipation Decreases Health Care Utilization. J Pediatr Gastroenterol Nutr. 2022 Nov 1; 75: 589-594.
• Hawa K, Lu PL, Holzmacher M, Wall J, Bali N, Vaz K, Yacob D, Di Lorenzo C, Van Diest AK. INTENSIVE OUTPATIENT TREATMENT OF PEDIATRIC RUMINATION SYNDROME IN THE ERA OF TELEMEDICINE. J Pediatr Gastroenterol Nutr. 2022 Jul 28;
• Baaleman DF, Hallagan A, Halleran DR, Orsagh-Yentis DK, Levitt MA, Wood RJ, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. Anal Botulinum Toxin in Children with Hirschsprung Disease and Functional Constipation: A Prospective Cohort study. Eur J Pediatr Surg. 2022 Jul 19;
• Baaleman DF, Vriesman MH, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL, Koppen IJN. Do we need an extra dimension? A pilot study on the use of three-dimensional anorectal manometry in children with functional constipation. Neurogastroenterol Motil. 2022 Apr 4; e14370.
• Baaleman DF, Vriesman MH, Koppen IJN, Osborne KM, Benninga MA, Saps M, Yacob D, Lu PL, Woodley FW, Lorenzo CD. Hypnosis to Reduce Distress in Children Undergoing Anorectal Manometry: A Randomized Controlled Pilot Trial. J Neurogastroenterol Motil. 2022 Apr 30; 28: 312-319.
• Di Lorenzo C. Functional Nausea Is Real and Makes You Sick. Front Pediatr. 2022; 10: 848659.
• Nurko S, Saps M, Kossovsky J, Zion SR, Di Lorenzo C, Vaz K, Hawthorne K, Wu R, Ciciora S, Rosen JM, Kaptchuk TJ, Kelley JM. Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome: A Randomized Clinical Trial. JAMA Pediatr. 2022 Jan 31;
• Strisciuglio C, Martinelli M, Lu P, Bar Lev MR, Beinvogl B, Benninga MA, Di Lorenzo C, Fiori Nastro F, Nurko S, Pearlstein H, Rosen R, Shamir R, Staiano A. Overall Impact of Coronavirus Disease 2019 Outbreak in Children With Functional Abdominal Pain Disorders: Results From the First Pandemic Phase. J Pediatr Gastroenterol Nutr. 2021 Dec 1; 73: 689-694.
• Ahmad H, Levitt MA, Yacob D, Halleran DR, Gasior AC, Di Lorenzo C, Wood RJ, Langer JC. Evaluation and Management of Persistent Problems After Surgery for Hirschsprung Disease in a Child. Curr Gastroenterol Rep. 2021 Oct 11; 23: 18.
• Orsagh-Yentis DK, Ryan K, Hurwitz N, Diefenbach KA, Teich S, Mousa H, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Gastric electrical stimulation improves symptoms and need for supplemental nutrition in children with severe nausea and vomiting: A ten-year experience. Neurogastroenterol Motil. 2021 Sep; 33: e14199.
• Saps M, Nurko S, Benninga MA, Di Lorenzo C, Garza JM, Thapar N, Richards K, Lee JJ, Altepeter T. A Collaborative Effort to Advance Drug Development in Pediatric Constipation and Irritable Bowel Syndrome. J Pediatr Gastroenterol Nutr. 2021 Aug 1; 73: 145-149.
• Madani S, Madani R, Parikh S, Manivannan A, Orellana WR, Thomas R, Di Lorenzo C. Symptomatic Treatment of Pain-Related Pediatric Functional Gastrointestinal Disorders in a Biopsychosocial Construct, and a Validity Study of Rome III Criteria. Clin Pediatr (Phila). 2021 Jun; 60: 304-313.
• Baaleman DF, Gupta S, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The Use of Linaclotide in Children with Functional Constipation or Irritable Bowel Syndrome: A Retrospective Chart Review. Paediatr Drugs. 2021 May; 23: 307-314.
• Abdulkader ZM, Bali N, Vaz K, Yacob D, Di Lorenzo C, Lu PL. Predictors of Hospital Admission for Pediatric Cyclic Vomiting Syndrome. J Pediatr. 2021 May; 232: 154-158.
• Benninga MA, Hussain SZ, Sood MR, Nurko S, Hyman P, Clifford RA, O’Gorman M, Losch-Beridon T, Mareya S, Lichtlen P, Di Lorenzo C. Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-Blind Study With Long-term Extension. Clin Gastroenterol Hepatol. 2021 Apr 7;
• Seilhamer C, Di Lorenzo C, Holstine J, Samora JB. Creating a bowel management plan for pediatric orthopaedic spine surgery patients. Spine Deform. 2021 Mar; 9: 365-371.
• Elfar W, Gurjar AA, Talukder MAH, Noble M, Di Lorenzo C, Elfar J. Erythropoietin promotes functional recovery in a mouse model of postoperative ileus. Neurogastroenterol Motil. 2021 Feb; 33: e14049.
• Khlevner J, Rosen R, Ambartsumyan L, Lusman SS, Rosen JM, Yacob D, Mousa H, Nurko S, Di Lorenzo C, Boruta M, Ratcliffe EM, Feinstein L, Snyder J, Wood RJ, Graham K, Saps M, Gyawali CP, Rodriguez L, Belkind-Gerson J. Development of Entrustable Professional Activities and Standards in Training in Pediatric Neurogastroenterology and Motility: North American Society for Pediatric Gastroenterology, Hepatology and Nutrition and American Neurogastroenterology and Motility Society Position Paper. J Pediatr Gastroenterol Nutr. 2021 Jan 1; 72: 168-180.
• Yacob D, Kroon Van Diest AM, Di Lorenzo C. Functional abdominal pain in adolescents: case-based management. Frontline Gastroenterol. 2021; 12: 629-635.
• Baaleman DF, Malamisura M, Benninga MA, Bali N, Vaz KH, Yacob D, Di Lorenzo C, Lu PL. The not-so-rare absent RAIR: Internal anal sphincter achalasia in a review of 1072 children with constipation undergoing high-resolution anorectal manometry. Neurogastroenterol Motil. 2020 Dec 10; e14028.
• Jadcherla SR, Hasenstab KA, Wei L, Osborn EK, Viswanathan S, Gulati IK, Slaughter JL, Di Lorenzo C. Role of feeding strategy bundle with acid-suppressive therapy in infants with esophageal acid reflux exposure: a randomized controlled trial. Pediatr Res. 2020 May 7;
• Jadcherla SR, Sultana Z, Hasenstab-Kenney KA, Prabhakar V, Gulati IK, Di Lorenzo C. Differentiating esophageal sensitivity phenotypes using pH-impedance in intensive care unit infants referred for gastroesophageal reflux symptoms. Pediatr Res. 2020 May 6;
• Di Lorenzo C. Gastroparesis in children: Paralysis for the child or the provider? Neurogastroenterol Motil. 2020 Mar; 32: e13792.
• Chumpitazi BP, Lewis J, Cooper D, D’Amato M, Lim J, Gupta S, Miranda A, Terry N, Mehta D, Scheimann A, O’Gorman M, Tipnis N, Davies Y, Friedlander J, Smith H, Punati J, Khlevner J, Setty M, Di Lorenzo C. Hypomorphic SI genetic variants are associated with childhood chronic loose stools. PLoS One. 2020; 15: e0231891.
• Halleran DR, Lu PL, Ahmad H, Paradiso MM, Lehmkuhl H, Akers A, Hallagan A, Bali N, Vaz K, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. Anal sphincter botulinum toxin injection in children with functional anorectal and colonic disorders: A large institutional study and review of the literature focusing on complications. J Pediatr Surg. 2019 Nov; 54: 2305-2310.
• Corsetti M, Costa M, Bassotti G, Bharucha AE, Borrelli O, Dinning P, Di Lorenzo C, Huizinga JD, Jimenez M, Rao S, Spiller R, Spencer NJ, Lentle R, Pannemans J, Thys A, Benninga M, Tack J. First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques. Nat Rev Gastroenterol Hepatol. 2019 Jul 11;
• Di Lorenzo C, Nurko S. It’s Ok to be Negative! J Pediatr Gastroenterol Nutr. 2019 Jun 17;
• Murray HB, Juarascio AS, Di Lorenzo C, Drossman DA, Thomas JJ. Diagnosis and Treatment of Rumination Syndrome: A Critical Review. Am J Gastroenterol. 2019 Apr; 114: 562-578.
• Vilanova-Sanchez A, Halleran DR, Reck-Burneo CA, Gasior AC, Weaver L, Fisher M, Wagner A, Nash O, Booth K, Peters K, Williams C, Brown SM, Lu P, Fuchs M, Diefenbach K, Leonard JR, Hewitt G, McCracken K, Di Lorenzo C, Wood RJ, Levitt MA. A descriptive model for a multidisciplinary unit for colorectal and pelvic malformations. J Pediatr Surg. 2019 Mar; 54: 479-485.
• Di Lorenzo C. 2018 Harry Shwachman Award. J Pediatr Gastroenterol Nutr. 2019 Mar; 68: 291.
• Halleran DR, Vilanova-Sanchez A, Rentea RM, Vriesman MH, Maloof T, Lu PL, Onwuka A, Weaver L, Vaz KK, Yacob D, Di Lorenzo C, Levitt MA, Wood RJ. A comparison of Malone appendicostomy and cecostomy for antegrade access as adjuncts to a bowel management program for patients with functional constipation or fecal incontinence. J Pediatr Surg. 2019 Jan; 54: 123-128.
• Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ. Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference. Gastroenterology. 2018 Sep 6;
• Gasior A, Reck C, Vilanova-Sanchez A, Diefenbach KA, Yacob D, Lu P, Vaz K, Di Lorenzo C, Levitt MA, Wood RJ. Surgical management of functional constipation: An intermediate report of a new approach using a laparoscopic sigmoid resection combined with malone appendicostomy. J Pediatr Surg. 2018 Jun; 53: 1160-1162.
• Thapar N, Saliakellis E, Benninga MA, Borrelli O, Curry J, Faure C, De Giorgio R, Gupte G, Knowles CH, Staiano A, Vandenplas Y, Di Lorenzo C. Paediatric Intestinal Pseudo-obstruction: Evidence and Consensus-based Recommendations From an ESPGHAN-Led Expert Group. J Pediatr Gastroenterol Nutr. 2018 Jun; 66: 991-1019.
• Saps M, Lavigne JV, van Tilburg MA, Miranda A, Benninga MA, Taminiau JA, Di Lorenzo C. Endpoints, reliability, and meaningful changes in clinical trials for children with irritable bowel syndrome. The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 May; 30: e13308.
• Koppen IJN, Vriesman MH, Tabbers MM, Di Lorenzo C, Benninga MA. Awareness and Implementation of the 2014 ESPGHAN/NASPGHAN Guideline for Childhood Functional Constipation. J Pediatr Gastroenterol Nutr. 2018 May; 66: 732-737.
• Di Lorenzo C. 2017 NASPGHAN Distinguished Service Award. J Pediatr Gastroenterol Nutr. 2018 May; 66: 713-714.
• Koppen IJN, Vriesman MH, Saps M, Rajindrajith S, Shi X, van Etten-Jamaludin FS, Di Lorenzo C, Benninga MA, Tabbers MM. Prevalence of Functional Defecation Disorders in Children: A Systematic Review and Meta-Analysis. J Pediatr. 2018 Apr 12;
• Koppen IJN, Saps M, Lavigne JV, Nurko S, Taminiau JAJM, Di Lorenzo C, Benninga MA. Recommendations for pharmacological clinical trials in children with functional constipation: The Rome foundation pediatric subcommittee on clinical trials. Neurogastroenterol Motil. 2018 Apr; 30: e13294.
• Williams KC, Rogers LK, Hill I, Barnard J, Di Lorenzo C. PEG 3350 Administration Is Not Associated with Sustained Elevation of Glycol Levels. J Pediatr. 2018 Apr; 195: 148-153.e1.
• Robin SG, Keller C, Zwiener R, Hyman PE, Nurko S, Saps M, Di Lorenzo C, Shulman RJ, Hyams JS, Palsson O, van Tilburg MAL. Prevalence of Pediatric Functional Gastrointestinal Disorders Utilizing the Rome IV Criteria. J Pediatr. 2018 Apr; 195: 134-139.
• Manini ML, Camilleri M, Grothe R, Di Lorenzo C. Application of Pyridostigmine in Pediatric Gastrointestinal Motility Disorders: A Case Series. Paediatr Drugs. 2018 Apr; 20: 173-180.
• Rosen R, Vandenplas Y, Singendonk M, Cabana M, DiLorenzo C, Gottrand F, Gupta S, Langendam M, Staiano A, Thapar N, Tipnis N, Tabbers M. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. 2018 Mar; 66: 516-554.
• Chang L, Di Lorenzo C, Farrugia G, Hamilton FA, Mawe GM, Pasricha PJ, Wiley JW. Functional Bowel Disorders: A Roadmap to Guide the Next Generation of Research. Gastroenterology. 2018 Feb; 154: 723-735.
• Lu PL, Koppen IJN, Orsagh-Yentis DK, Leonhart K, Ambeba EJ, Deans KJ, Minneci PC, Teich S, Diefenbach KA, Alpert SA, Benninga MA, Yacob D, Di Lorenzo C. Sacral nerve stimulation for constipation and fecal incontinence in children: Long-term outcomes, patient benefit, and parent satisfaction. Neurogastroenterol Motil. 2018 Feb; 30:
• Kuizenga-Wessel S, Koppen IJN, Vriesman MH, Di Lorenzo C, van Dijk M, Beelen MLR, Groeneweg M, Stoffelsen RJ, Benninga MA. Attention Deficit Hyperactivity Disorder and Functional Defecation Disorders in Children. J Pediatr Gastroenterol Nutr. 2018 Feb; 66: 244-249.
• Alioto A, Di Lorenzo C. Long-term Follow-up of Adolescents Treated for Rumination Syndrome in an Inpatient Setting. J Pediatr Gastroenterol Nutr. 2018 Jan; 66: 21-25.
• Vriesman MH, Velasco-Benitez CA, Ramirez CR, Benninga MA, Di Lorenzo C, Saps M. Assessing Children’s Report of Stool Consistency: Agreement Between the Pediatric Rome III Questionnaire and the Bristol Stool Scale. J Pediatr. 2017 Nov; 190: 69-73.
• Koppen IJN, Thompson BP, Ambeba EJ, Lane VA, Bates DG, Minneci PC, Deans KJ, Levitt MA, Wood RJ, Benninga MA, Di Lorenzo C, Yacob D. Segmental colonic dilation is associated with premature termination of high-amplitude propagating contractions in children with intractable functional constipation. Neurogastroenterol Motil. 2017 Oct; 29: 1-9.
• Woodley FW, Moore-Clingenpeel M, Machado RS, Nemastil CJ, Jadcherla SR, Hayes D Jr, Kopp BT, Kaul A, Di Lorenzo C, Mousa H. Not All Children with Cystic Fibrosis Have Abnormal Esophageal Neutralization during Chemical Clearance of Acid Reflux. Pediatr Gastroenterol Hepatol Nutr. 2017 Sep; 20: 153-159.
• Alioto A, Di Lorenzo C, Montgomery ML, Yacob D. High Cost and Low Yield: The Diagnostic Evaluation of Rumination Syndrome in Pediatrics. J Pediatr. 2017 Jun; 185: 155-159.
• Kuizenga-Wessel S, Koppen IJN, Zwager LW, Di Lorenzo C, de Jong JR, Benninga MA. Surgical management of children with intractable functional constipation; experience of a single tertiary children’s hospital. Neurogastroenterol Motil. 2017 May; 29:
• Lu PL, Asti L, Lodwick DL, Nacion KM, Deans KJ, Minneci PC, Teich S, Alpert SA, Yacob D, Di Lorenzo C, Mousa HM. Sacral nerve stimulation allows for decreased antegrade continence enema use in children with severe constipation. J Pediatr Surg. 2017 Apr; 52: 558-562.
• Vandenplas Y, Szajewska H, Benninga M, Di Lorenzo C, Dupont C, Faure C, Miqdadi M, Osatakul S, Ribes-Konickx C, Saps M, Shamir R, Staiano A, BITSS Study Group.. Development of the Brussels Infant and Toddler Stool Scale (‘BITSS’): protocol of the study. BMJ Open. 2017 Mar 29; 7: e014620.
• Koppen IJ, Yacob D, Di Lorenzo C, Saps M, Benninga MA, Cooper JN, Minneci PC, Deans KJ, Bates DG, Thompson BP. Assessing colonic anatomy normal values based on air contrast enemas in children younger than 6 years. Pediatr Radiol. 2017 Mar; 47: 306-312.
• Peeters B, Vriesman MH, Koppen IJN, van Dijk M, Grootenhuis MA, Di Lorenzo C, Benninga MA. Parental characteristics and functional constipation in children: a cross-sectional cohort study. BMJ Paediatr Open. 2017; 1: e000100.

Education

Date of Appointment at Nationwide Children’s Hospital: 08/27/2004

Board Certifications

Pediatric Gastroenterology

Fellowship

Harbor UCLA Medical Center

Date Completed: 06/30/1990

Fellowship

University of Southern California County Hospital

Date Completed: 04/30/1988

Fellowship

Hospital Universitaire des Enfants - Brussels

Date Completed: 12/31/1986

Residency

2nd University of Naples - Italy

Date Completed: 07/31/1988

Internship

2nd University of Naples - Italy

Date Completed: 07/31/1986

Medical School

2nd University of Naples - Italy

Date Completed: 07/31/1984

Education

Date of Appointment at Nationwide Children’s Hospital: 08/27/2004

Board Certifications

Pediatric Gastroenterology

Fellowship

Harbor UCLA Medical Center

Date Completed: 06/30/1990

Fellowship

University of Southern California County Hospital

Date Completed: 04/30/1988

Fellowship

Hospital Universitaire des Enfants - Brussels

Date Completed: 12/31/1986

Residency

2nd University of Naples - Italy

Date Completed: 07/31/1988

Internship

2nd University of Naples - Italy

Date Completed: 07/31/1986

Medical School

2nd University of Naples - Italy

Date Completed: 07/31/1984

Education

Date of Appointment at Nationwide Children’s Hospital: 08/27/2004

Board Certifications

Pediatric Gastroenterology

Fellowship

Harbor UCLA Medical Center

Date Completed: 06/30/1990

Fellowship

University of Southern California County Hospital

Date Completed: 04/30/1988

Fellowship

Hospital Universitaire des Enfants - Brussels

Date Completed: 12/31/1986

Residency

2nd University of Naples - Italy

Date Completed: 07/31/1988

Internship

2nd University of Naples - Italy

Date Completed: 07/31/1986

Medical School

2nd University of Naples - Italy

Date Completed: 07/31/1984

Date of Appointment at Nationwide Children’s Hospital: 08/27/2004

Board Certifications

Pediatric Gastroenterology

Fellowship

Harbor UCLA Medical Center

Date Completed: 06/30/1990

Fellowship

University of Southern California County Hospital

Date Completed: 04/30/1988

Fellowship

Hospital Universitaire des Enfants - Brussels

Date Completed: 12/31/1986

Residency

2nd University of Naples - Italy

Date Completed: 07/31/1988

Internship

2nd University of Naples - Italy

Date Completed: 07/31/1986

Medical School

2nd University of Naples - Italy

Date Completed: 07/31/1984

Date of Appointment at Nationwide Children’s Hospital: 08/27/2004

Board Certifications

Pediatric Gastroenterology

Fellowship

Harbor UCLA Medical Center

Date Completed: 06/30/1990

Fellowship

University of Southern California County Hospital

Date Completed: 04/30/1988

Fellowship

Hospital Universitaire des Enfants - Brussels

Date Completed: 12/31/1986

Residency

2nd University of Naples - Italy

Date Completed: 07/31/1988

Internship

2nd University of Naples - Italy

Date Completed: 07/31/1986

Medical School

2nd University of Naples - Italy

Date Completed: 07/31/1984

• Pediatric Gastroenterology

Contact Information

Pediatrics

Call us at: (614) 722-3450

Fax us at: (614) 722-3454

                    Gastroenterology & Hepatology & Nutrition700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pediatrics

Call us at: (614) 722-3450

Fax us at: (614) 722-3454

                    Gastroenterology & Hepatology & Nutrition700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pediatrics

Call us at: (614) 722-3450

Fax us at: (614) 722-3454

                    Gastroenterology & Hepatology & Nutrition700 Children's DrColumbus, OH 43205 (map)

Pediatrics

Call us at: (614) 722-3450

Fax us at: (614) 722-3454

                    Gastroenterology & Hepatology & Nutrition700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-3450

Fax us at: (614) 722-3454

                    Gastroenterology & Hepatology & Nutrition700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-3450

Fax us at: (614) 722-3454

                    Gastroenterology & Hepatology & Nutrition700 Children's DrColumbus, OH 43205 (map)

• Call us at:
• (614) 722-3450
• Fax us at:
• (614) 722-3454
• Gastroenterology & Hepatology & Nutrition700 Children’s DrColumbus, OH 43205 (map)

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