Contact Information

Call us at: (614)355.5750

Fax us at: (614)355-5725

      Abigail Wexner Research Institute700 Children's DriveColumbus, OH 43205 (map)

Learn more about Brenda Lilly

Biography

Dr. Brenda Lilly is a Principal Investigator for the Center for Cardiovascular and Pulmonary Research at Nationwide Children’s Hospital and a Professor at The Ohio State University. She is a developmental biologist that studies the molecular pathways involved in blood vessel formation. Her lab examines the interactions between endothelial cells and smooth muscle cells that govern differentiation in normal and diseased states.

Academic and Clinical Areas

Center for Cardiovascular Research

Principal Investigator

Brenda Lilly Lab

Principal Investigator

Heart Center

Principal Investigator

Research

Lab(s)

Center for Cardiovascular Research

Dr. Lilly’s research focuses on understanding the regulatory pathways that control vascular development and smooth muscle differentiation. Using a 3-D culture system to grow blood vessels in vitro, her lab is investigating how smooth muscle precursors are summoned to the nascent vessel. Recruitment of smooth muscle cells is thought to be dependent upon paracrine signals emanating from the endothelial cell tube; however the mechanisms of these signaling events remain a mystery. Dr. Lilly is also working to define the transcriptional mechanisms that govern selective gene expression in smooth muscle cells. Using smooth muscle regulatory enhancers as tools, her lab directly tests the response that individual components of signaling pathways have on gene expression.

View My Publications

Publications

                  Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.

                


                  Thomas S, Manivannan S, Garg V, Lilly B. Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature J Vasc Res. 2022 Mar 16;  1-13.

                


                  Thomas S, Manivannan S, Sawant D, Kodigepalli KM, Garg V, Conway SJ, Lilly B. miR-145 transgenic mice develop cardiopulmonary complications leading to postnatal death. Physiol Rep. 2021 Sep; 9: e15013.

                


                  Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 

                


                  Breikaa RM, Lilly B. The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications. Front Cardiovasc Med. 2021; 8: 681948.

                


                  Sawant D, Klevenow E, Baeten JT, Thomas S, Manivannan S, Conway SJ, Lilly B. Generation of transgenic mice that conditionally express microRNA miR-145. Genesis. 2020 Sep; 58: e23385.

                


                  Sawant D, Lilly B. MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways. Vasc Biol. 2020; 2: R115-R128.

                


                  L Snider P, Snider E, Simmons O, Lilly B, J Conway S. Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis. J Cardiovasc Dev Dis. 2019 Jun 22; 6: 

                


                  Lilly B, Dammeyer K, Marosis S, McCallinhart PE, Trask AJ, Lowe M, Sawant D. Endothelial cell-induced cytoglobin expression in vascular smooth muscle cells contributes to modulation of nitric oxide. Vascul Pharmacol. 2018 Nov; 110: 7-15.

                


                  Liu H, Zhang W, Lilly B. Evaluation of Notch3 Deficiency in Diabetes-Induced Pericyte Loss in the Retina. J Vasc Res. 2018 Oct 22; 55: 308-318.

                


                  Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 

                


                  Baeten JT, Lilly B. Notch Signaling in Vascular Smooth Muscle Cells. Adv Pharmacol. 2017; 78: 351-382.

View More Publications

Professional Experience

2020 - Present Department of Pediatrics, The Ohio State University Medical Center, Professor2010 - Present Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children’s Hospital, Principal Investigator2010 - 2020 Department of Pediatrics, The Ohio State University Medical Center, Associate Professor2007 - 2010 Vascular Biology Center, Department of Obstetrics and Gynecology, Medical College of Georgia, Associate Professor2002 - 2007 Vascular Biology Center, Department of Obstetrics and Gynecology, Medical College of Georgia, Assistant Professor1998 - 2002 Huntsman Cancer Institute, University of Utah, Postdoctoral Research1995 - 1998 Department of Molecular and Human Genetics, Baylor College of Medicine, Postdoctoral Research1991 - 1995 PhD Dissertation: The molecular and genetic characterization of the MADS box transcription factor Drosophila MEF2

Contact Information

Call us at: (614)355.5750

Fax us at: (614)355-5725

                    Abigail Wexner Research Institute700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Call us at: (614)355.5750

Fax us at: (614)355-5725

      Abigail Wexner Research Institute700 Children's DriveColumbus, OH 43205 (map)

Learn more about Brenda Lilly

Biography

Dr. Brenda Lilly is a Principal Investigator for the Center for Cardiovascular and Pulmonary Research at Nationwide Children’s Hospital and a Professor at The Ohio State University. She is a developmental biologist that studies the molecular pathways involved in blood vessel formation. Her lab examines the interactions between endothelial cells and smooth muscle cells that govern differentiation in normal and diseased states.

Academic and Clinical Areas

Center for Cardiovascular Research

Principal Investigator

Brenda Lilly Lab

Principal Investigator

Heart Center

Principal Investigator

Research

Lab(s)

Center for Cardiovascular Research

Dr. Lilly’s research focuses on understanding the regulatory pathways that control vascular development and smooth muscle differentiation. Using a 3-D culture system to grow blood vessels in vitro, her lab is investigating how smooth muscle precursors are summoned to the nascent vessel. Recruitment of smooth muscle cells is thought to be dependent upon paracrine signals emanating from the endothelial cell tube; however the mechanisms of these signaling events remain a mystery. Dr. Lilly is also working to define the transcriptional mechanisms that govern selective gene expression in smooth muscle cells. Using smooth muscle regulatory enhancers as tools, her lab directly tests the response that individual components of signaling pathways have on gene expression.

View My Publications

Publications

                  Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.

                


                  Thomas S, Manivannan S, Garg V, Lilly B. Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature J Vasc Res. 2022 Mar 16;  1-13.

                


                  Thomas S, Manivannan S, Sawant D, Kodigepalli KM, Garg V, Conway SJ, Lilly B. miR-145 transgenic mice develop cardiopulmonary complications leading to postnatal death. Physiol Rep. 2021 Sep; 9: e15013.

                


                  Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 

                


                  Breikaa RM, Lilly B. The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications. Front Cardiovasc Med. 2021; 8: 681948.

                


                  Sawant D, Klevenow E, Baeten JT, Thomas S, Manivannan S, Conway SJ, Lilly B. Generation of transgenic mice that conditionally express microRNA miR-145. Genesis. 2020 Sep; 58: e23385.

                


                  Sawant D, Lilly B. MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways. Vasc Biol. 2020; 2: R115-R128.

                


                  L Snider P, Snider E, Simmons O, Lilly B, J Conway S. Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis. J Cardiovasc Dev Dis. 2019 Jun 22; 6: 

                


                  Lilly B, Dammeyer K, Marosis S, McCallinhart PE, Trask AJ, Lowe M, Sawant D. Endothelial cell-induced cytoglobin expression in vascular smooth muscle cells contributes to modulation of nitric oxide. Vascul Pharmacol. 2018 Nov; 110: 7-15.

                


                  Liu H, Zhang W, Lilly B. Evaluation of Notch3 Deficiency in Diabetes-Induced Pericyte Loss in the Retina. J Vasc Res. 2018 Oct 22; 55: 308-318.

                


                  Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 

                


                  Baeten JT, Lilly B. Notch Signaling in Vascular Smooth Muscle Cells. Adv Pharmacol. 2017; 78: 351-382.

View More Publications

Professional Experience

2020 - Present Department of Pediatrics, The Ohio State University Medical Center, Professor2010 - Present Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children’s Hospital, Principal Investigator2010 - 2020 Department of Pediatrics, The Ohio State University Medical Center, Associate Professor2007 - 2010 Vascular Biology Center, Department of Obstetrics and Gynecology, Medical College of Georgia, Associate Professor2002 - 2007 Vascular Biology Center, Department of Obstetrics and Gynecology, Medical College of Georgia, Assistant Professor1998 - 2002 Huntsman Cancer Institute, University of Utah, Postdoctoral Research1995 - 1998 Department of Molecular and Human Genetics, Baylor College of Medicine, Postdoctoral Research1991 - 1995 PhD Dissertation: The molecular and genetic characterization of the MADS box transcription factor Drosophila MEF2

Contact Information

Call us at: (614)355.5750

Fax us at: (614)355-5725

                    Abigail Wexner Research Institute700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Call us at: (614)355.5750

Fax us at: (614)355-5725

      Abigail Wexner Research Institute700 Children's DriveColumbus, OH 43205 (map)

Learn more about Brenda Lilly

Contact Information

  • Call us at:
  • (614)355.5750
  • Fax us at:
  • (614)355-5725
  • Abigail Wexner Research Institute700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Brenda Lilly

Biography

Dr. Brenda Lilly is a Principal Investigator for the Center for Cardiovascular and Pulmonary Research at Nationwide Children’s Hospital and a Professor at The Ohio State University. She is a developmental biologist that studies the molecular pathways involved in blood vessel formation. Her lab examines the interactions between endothelial cells and smooth muscle cells that govern differentiation in normal and diseased states.

Biography

Dr. Brenda Lilly is a Principal Investigator for the Center for Cardiovascular and Pulmonary Research at Nationwide Children’s Hospital and a Professor at The Ohio State University. She is a developmental biologist that studies the molecular pathways involved in blood vessel formation. Her lab examines the interactions between endothelial cells and smooth muscle cells that govern differentiation in normal and diseased states.

Biography

Dr. Brenda Lilly is a Principal Investigator for the Center for Cardiovascular and Pulmonary Research at Nationwide Children’s Hospital and a Professor at The Ohio State University. She is a developmental biologist that studies the molecular pathways involved in blood vessel formation. Her lab examines the interactions between endothelial cells and smooth muscle cells that govern differentiation in normal and diseased states.

Dr. Brenda Lilly is a Principal Investigator for the Center for Cardiovascular and Pulmonary Research at Nationwide Children’s Hospital and a Professor at The Ohio State University. She is a developmental biologist that studies the molecular pathways involved in blood vessel formation. Her lab examines the interactions between endothelial cells and smooth muscle cells that govern differentiation in normal and diseased states.

Dr. Brenda Lilly is a Principal Investigator for the Center for Cardiovascular and Pulmonary Research at Nationwide Children’s Hospital and a Professor at The Ohio State University. She is a developmental biologist that studies the molecular pathways involved in blood vessel formation. Her lab examines the interactions between endothelial cells and smooth muscle cells that govern differentiation in normal and diseased states.

Academic and Clinical Areas

Center for Cardiovascular Research

Principal Investigator

Brenda Lilly Lab

Principal Investigator

Heart Center

Principal Investigator

Academic and Clinical Areas

Center for Cardiovascular Research

Principal Investigator

Brenda Lilly Lab

Principal Investigator

Heart Center

Principal Investigator

Academic and Clinical Areas

Center for Cardiovascular Research

Principal Investigator

Brenda Lilly Lab

Principal Investigator

Heart Center

Principal Investigator

Center for Cardiovascular Research

Principal Investigator

Brenda Lilly Lab

Principal Investigator

Heart Center

Principal Investigator

  • Center for Cardiovascular Research
  • Principal Investigator
  • Brenda Lilly Lab
  • Principal Investigator
  • Heart Center
  • Principal Investigator

Research

Lab(s)

Center for Cardiovascular Research

Dr. Lilly’s research focuses on understanding the regulatory pathways that control vascular development and smooth muscle differentiation. Using a 3-D culture system to grow blood vessels in vitro, her lab is investigating how smooth muscle precursors are summoned to the nascent vessel. Recruitment of smooth muscle cells is thought to be dependent upon paracrine signals emanating from the endothelial cell tube; however the mechanisms of these signaling events remain a mystery. Dr. Lilly is also working to define the transcriptional mechanisms that govern selective gene expression in smooth muscle cells. Using smooth muscle regulatory enhancers as tools, her lab directly tests the response that individual components of signaling pathways have on gene expression.

View My Publications

Publications

                  Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.

                


                  Thomas S, Manivannan S, Garg V, Lilly B. Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature J Vasc Res. 2022 Mar 16;  1-13.

                


                  Thomas S, Manivannan S, Sawant D, Kodigepalli KM, Garg V, Conway SJ, Lilly B. miR-145 transgenic mice develop cardiopulmonary complications leading to postnatal death. Physiol Rep. 2021 Sep; 9: e15013.

                


                  Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 

                


                  Breikaa RM, Lilly B. The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications. Front Cardiovasc Med. 2021; 8: 681948.

                


                  Sawant D, Klevenow E, Baeten JT, Thomas S, Manivannan S, Conway SJ, Lilly B. Generation of transgenic mice that conditionally express microRNA miR-145. Genesis. 2020 Sep; 58: e23385.

                


                  Sawant D, Lilly B. MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways. Vasc Biol. 2020; 2: R115-R128.

                


                  L Snider P, Snider E, Simmons O, Lilly B, J Conway S. Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis. J Cardiovasc Dev Dis. 2019 Jun 22; 6: 

                


                  Lilly B, Dammeyer K, Marosis S, McCallinhart PE, Trask AJ, Lowe M, Sawant D. Endothelial cell-induced cytoglobin expression in vascular smooth muscle cells contributes to modulation of nitric oxide. Vascul Pharmacol. 2018 Nov; 110: 7-15.

                


                  Liu H, Zhang W, Lilly B. Evaluation of Notch3 Deficiency in Diabetes-Induced Pericyte Loss in the Retina. J Vasc Res. 2018 Oct 22; 55: 308-318.

                


                  Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 

                


                  Baeten JT, Lilly B. Notch Signaling in Vascular Smooth Muscle Cells. Adv Pharmacol. 2017; 78: 351-382.

View More Publications

Research

Lab(s)

Center for Cardiovascular Research

Dr. Lilly’s research focuses on understanding the regulatory pathways that control vascular development and smooth muscle differentiation. Using a 3-D culture system to grow blood vessels in vitro, her lab is investigating how smooth muscle precursors are summoned to the nascent vessel. Recruitment of smooth muscle cells is thought to be dependent upon paracrine signals emanating from the endothelial cell tube; however the mechanisms of these signaling events remain a mystery. Dr. Lilly is also working to define the transcriptional mechanisms that govern selective gene expression in smooth muscle cells. Using smooth muscle regulatory enhancers as tools, her lab directly tests the response that individual components of signaling pathways have on gene expression.

View My Publications

Publications

                  Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.

                


                  Thomas S, Manivannan S, Garg V, Lilly B. Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature J Vasc Res. 2022 Mar 16;  1-13.

                


                  Thomas S, Manivannan S, Sawant D, Kodigepalli KM, Garg V, Conway SJ, Lilly B. miR-145 transgenic mice develop cardiopulmonary complications leading to postnatal death. Physiol Rep. 2021 Sep; 9: e15013.

                


                  Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 

                


                  Breikaa RM, Lilly B. The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications. Front Cardiovasc Med. 2021; 8: 681948.

                


                  Sawant D, Klevenow E, Baeten JT, Thomas S, Manivannan S, Conway SJ, Lilly B. Generation of transgenic mice that conditionally express microRNA miR-145. Genesis. 2020 Sep; 58: e23385.

                


                  Sawant D, Lilly B. MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways. Vasc Biol. 2020; 2: R115-R128.

                


                  L Snider P, Snider E, Simmons O, Lilly B, J Conway S. Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis. J Cardiovasc Dev Dis. 2019 Jun 22; 6: 

                


                  Lilly B, Dammeyer K, Marosis S, McCallinhart PE, Trask AJ, Lowe M, Sawant D. Endothelial cell-induced cytoglobin expression in vascular smooth muscle cells contributes to modulation of nitric oxide. Vascul Pharmacol. 2018 Nov; 110: 7-15.

                


                  Liu H, Zhang W, Lilly B. Evaluation of Notch3 Deficiency in Diabetes-Induced Pericyte Loss in the Retina. J Vasc Res. 2018 Oct 22; 55: 308-318.

                


                  Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 

                


                  Baeten JT, Lilly B. Notch Signaling in Vascular Smooth Muscle Cells. Adv Pharmacol. 2017; 78: 351-382.

View More Publications

Research

Lab(s)

Center for Cardiovascular Research

Dr. Lilly’s research focuses on understanding the regulatory pathways that control vascular development and smooth muscle differentiation. Using a 3-D culture system to grow blood vessels in vitro, her lab is investigating how smooth muscle precursors are summoned to the nascent vessel. Recruitment of smooth muscle cells is thought to be dependent upon paracrine signals emanating from the endothelial cell tube; however the mechanisms of these signaling events remain a mystery. Dr. Lilly is also working to define the transcriptional mechanisms that govern selective gene expression in smooth muscle cells. Using smooth muscle regulatory enhancers as tools, her lab directly tests the response that individual components of signaling pathways have on gene expression.

View My Publications

Publications

                  Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.

                


                  Thomas S, Manivannan S, Garg V, Lilly B. Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature J Vasc Res. 2022 Mar 16;  1-13.

                


                  Thomas S, Manivannan S, Sawant D, Kodigepalli KM, Garg V, Conway SJ, Lilly B. miR-145 transgenic mice develop cardiopulmonary complications leading to postnatal death. Physiol Rep. 2021 Sep; 9: e15013.

                


                  Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 

                


                  Breikaa RM, Lilly B. The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications. Front Cardiovasc Med. 2021; 8: 681948.

                


                  Sawant D, Klevenow E, Baeten JT, Thomas S, Manivannan S, Conway SJ, Lilly B. Generation of transgenic mice that conditionally express microRNA miR-145. Genesis. 2020 Sep; 58: e23385.

                


                  Sawant D, Lilly B. MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways. Vasc Biol. 2020; 2: R115-R128.

                


                  L Snider P, Snider E, Simmons O, Lilly B, J Conway S. Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis. J Cardiovasc Dev Dis. 2019 Jun 22; 6: 

                


                  Lilly B, Dammeyer K, Marosis S, McCallinhart PE, Trask AJ, Lowe M, Sawant D. Endothelial cell-induced cytoglobin expression in vascular smooth muscle cells contributes to modulation of nitric oxide. Vascul Pharmacol. 2018 Nov; 110: 7-15.

                


                  Liu H, Zhang W, Lilly B. Evaluation of Notch3 Deficiency in Diabetes-Induced Pericyte Loss in the Retina. J Vasc Res. 2018 Oct 22; 55: 308-318.

                


                  Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 

                


                  Baeten JT, Lilly B. Notch Signaling in Vascular Smooth Muscle Cells. Adv Pharmacol. 2017; 78: 351-382.

View More Publications

Lab(s)

Center for Cardiovascular Research

Dr. Lilly’s research focuses on understanding the regulatory pathways that control vascular development and smooth muscle differentiation. Using a 3-D culture system to grow blood vessels in vitro, her lab is investigating how smooth muscle precursors are summoned to the nascent vessel. Recruitment of smooth muscle cells is thought to be dependent upon paracrine signals emanating from the endothelial cell tube; however the mechanisms of these signaling events remain a mystery. Dr. Lilly is also working to define the transcriptional mechanisms that govern selective gene expression in smooth muscle cells. Using smooth muscle regulatory enhancers as tools, her lab directly tests the response that individual components of signaling pathways have on gene expression.

View My Publications

Publications

                  Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.

                


                  Thomas S, Manivannan S, Garg V, Lilly B. Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature J Vasc Res. 2022 Mar 16;  1-13.

                


                  Thomas S, Manivannan S, Sawant D, Kodigepalli KM, Garg V, Conway SJ, Lilly B. miR-145 transgenic mice develop cardiopulmonary complications leading to postnatal death. Physiol Rep. 2021 Sep; 9: e15013.

                


                  Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 

                


                  Breikaa RM, Lilly B. The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications. Front Cardiovasc Med. 2021; 8: 681948.

                


                  Sawant D, Klevenow E, Baeten JT, Thomas S, Manivannan S, Conway SJ, Lilly B. Generation of transgenic mice that conditionally express microRNA miR-145. Genesis. 2020 Sep; 58: e23385.

                


                  Sawant D, Lilly B. MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways. Vasc Biol. 2020; 2: R115-R128.

                


                  L Snider P, Snider E, Simmons O, Lilly B, J Conway S. Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis. J Cardiovasc Dev Dis. 2019 Jun 22; 6: 

                


                  Lilly B, Dammeyer K, Marosis S, McCallinhart PE, Trask AJ, Lowe M, Sawant D. Endothelial cell-induced cytoglobin expression in vascular smooth muscle cells contributes to modulation of nitric oxide. Vascul Pharmacol. 2018 Nov; 110: 7-15.

                


                  Liu H, Zhang W, Lilly B. Evaluation of Notch3 Deficiency in Diabetes-Induced Pericyte Loss in the Retina. J Vasc Res. 2018 Oct 22; 55: 308-318.

                


                  Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 

                


                  Baeten JT, Lilly B. Notch Signaling in Vascular Smooth Muscle Cells. Adv Pharmacol. 2017; 78: 351-382.

View More Publications

Lab(s)

Center for Cardiovascular Research

Dr. Lilly’s research focuses on understanding the regulatory pathways that control vascular development and smooth muscle differentiation. Using a 3-D culture system to grow blood vessels in vitro, her lab is investigating how smooth muscle precursors are summoned to the nascent vessel. Recruitment of smooth muscle cells is thought to be dependent upon paracrine signals emanating from the endothelial cell tube; however the mechanisms of these signaling events remain a mystery. Dr. Lilly is also working to define the transcriptional mechanisms that govern selective gene expression in smooth muscle cells. Using smooth muscle regulatory enhancers as tools, her lab directly tests the response that individual components of signaling pathways have on gene expression.

Lab(s)

Center for Cardiovascular Research

  • Center for Cardiovascular Research

  • View My Publications

                    Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.



                Thomas S, Manivannan S, Garg V, Lilly B. Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature J Vasc Res. 2022 Mar 16;  1-13.



                Thomas S, Manivannan S, Sawant D, Kodigepalli KM, Garg V, Conway SJ, Lilly B. miR-145 transgenic mice develop cardiopulmonary complications leading to postnatal death. Physiol Rep. 2021 Sep; 9: e15013.



                Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7: 



                Breikaa RM, Lilly B. The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications. Front Cardiovasc Med. 2021; 8: 681948.



                Sawant D, Klevenow E, Baeten JT, Thomas S, Manivannan S, Conway SJ, Lilly B. Generation of transgenic mice that conditionally express microRNA miR-145. Genesis. 2020 Sep; 58: e23385.



                Sawant D, Lilly B. MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways. Vasc Biol. 2020; 2: R115-R128.



                L Snider P, Snider E, Simmons O, Lilly B, J Conway S. Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis. J Cardiovasc Dev Dis. 2019 Jun 22; 6: 



                Lilly B, Dammeyer K, Marosis S, McCallinhart PE, Trask AJ, Lowe M, Sawant D. Endothelial cell-induced cytoglobin expression in vascular smooth muscle cells contributes to modulation of nitric oxide. Vascul Pharmacol. 2018 Nov; 110: 7-15.



                Liu H, Zhang W, Lilly B. Evaluation of Notch3 Deficiency in Diabetes-Induced Pericyte Loss in the Retina. J Vasc Res. 2018 Oct 22; 55: 308-318.



                Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2: 



                Baeten JT, Lilly B. Notch Signaling in Vascular Smooth Muscle Cells. Adv Pharmacol. 2017; 78: 351-382.

View More Publications

  • Breikaa RM, Denman K, Ueyama Y, McCallinhart PE, Khan AQ, Agarwal G, Trask AJ, Garg V, Lilly B. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes. Vascul Pharmacol. 2022 Jul 2; 145: 107087.
  • Thomas S, Manivannan S, Garg V, Lilly B. Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature J Vasc Res. 2022 Mar 16; 1-13.
  • Thomas S, Manivannan S, Sawant D, Kodigepalli KM, Garg V, Conway SJ, Lilly B. miR-145 transgenic mice develop cardiopulmonary complications leading to postnatal death. Physiol Rep. 2021 Sep; 9: e15013.
  • Majumdar U, Manivannan S, Basu M, Ueyama Y, Blaser MC, Cameron E, McDermott MR, Lincoln J, Cole SE, Wood S, Aikawa E, Lilly B, Garg V. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling. Sci Adv. 2021 Feb; 7:
  • Breikaa RM, Lilly B. The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications. Front Cardiovasc Med. 2021; 8: 681948.
  • Sawant D, Klevenow E, Baeten JT, Thomas S, Manivannan S, Conway SJ, Lilly B. Generation of transgenic mice that conditionally express microRNA miR-145. Genesis. 2020 Sep; 58: e23385.
  • Sawant D, Lilly B. MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways. Vasc Biol. 2020; 2: R115-R128.
  • L Snider P, Snider E, Simmons O, Lilly B, J Conway S. Analysis of Uncharacterized mKiaa1211 Expression during Mouse Development and Cardiovascular Morphogenesis. J Cardiovasc Dev Dis. 2019 Jun 22; 6:
  • Lilly B, Dammeyer K, Marosis S, McCallinhart PE, Trask AJ, Lowe M, Sawant D. Endothelial cell-induced cytoglobin expression in vascular smooth muscle cells contributes to modulation of nitric oxide. Vascul Pharmacol. 2018 Nov; 110: 7-15.
  • Liu H, Zhang W, Lilly B. Evaluation of Notch3 Deficiency in Diabetes-Induced Pericyte Loss in the Retina. J Vasc Res. 2018 Oct 22; 55: 308-318.
  • Koenig SN, LaHaye S, Feller JD, Rowland P, Hor KN, Trask AJ, Janssen PM, Radtke F, Lilly B, Garg V. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice. JCI Insight. 2017 Nov 2; 2:
  • Baeten JT, Lilly B. Notch Signaling in Vascular Smooth Muscle Cells. Adv Pharmacol. 2017; 78: 351-382.

Professional Experience

2020 - Present Department of Pediatrics, The Ohio State University Medical Center, Professor2010 - Present Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children’s Hospital, Principal Investigator2010 - 2020 Department of Pediatrics, The Ohio State University Medical Center, Associate Professor2007 - 2010 Vascular Biology Center, Department of Obstetrics and Gynecology, Medical College of Georgia, Associate Professor2002 - 2007 Vascular Biology Center, Department of Obstetrics and Gynecology, Medical College of Georgia, Assistant Professor1998 - 2002 Huntsman Cancer Institute, University of Utah, Postdoctoral Research1995 - 1998 Department of Molecular and Human Genetics, Baylor College of Medicine, Postdoctoral Research1991 - 1995 PhD Dissertation: The molecular and genetic characterization of the MADS box transcription factor Drosophila MEF2

Professional Experience

2020 - Present Department of Pediatrics, The Ohio State University Medical Center, Professor2010 - Present Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children’s Hospital, Principal Investigator2010 - 2020 Department of Pediatrics, The Ohio State University Medical Center, Associate Professor2007 - 2010 Vascular Biology Center, Department of Obstetrics and Gynecology, Medical College of Georgia, Associate Professor2002 - 2007 Vascular Biology Center, Department of Obstetrics and Gynecology, Medical College of Georgia, Assistant Professor1998 - 2002 Huntsman Cancer Institute, University of Utah, Postdoctoral Research1995 - 1998 Department of Molecular and Human Genetics, Baylor College of Medicine, Postdoctoral Research1991 - 1995 PhD Dissertation: The molecular and genetic characterization of the MADS box transcription factor Drosophila MEF2

Professional Experience

2020 - Present Department of Pediatrics, The Ohio State University Medical Center, Professor2010 - Present Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children’s Hospital, Principal Investigator2010 - 2020 Department of Pediatrics, The Ohio State University Medical Center, Associate Professor2007 - 2010 Vascular Biology Center, Department of Obstetrics and Gynecology, Medical College of Georgia, Associate Professor2002 - 2007 Vascular Biology Center, Department of Obstetrics and Gynecology, Medical College of Georgia, Assistant Professor1998 - 2002 Huntsman Cancer Institute, University of Utah, Postdoctoral Research1995 - 1998 Department of Molecular and Human Genetics, Baylor College of Medicine, Postdoctoral Research1991 - 1995 PhD Dissertation: The molecular and genetic characterization of the MADS box transcription factor Drosophila MEF2

2020 - Present Department of Pediatrics, The Ohio State University Medical Center, Professor2010 - Present Center for Cardiovascular and Pulmonary Research, The Research Institute at Nationwide Children’s Hospital, Principal Investigator2010 - 2020 Department of Pediatrics, The Ohio State University Medical Center, Associate Professor2007 - 2010 Vascular Biology Center, Department of Obstetrics and Gynecology, Medical College of Georgia, Associate Professor2002 - 2007 Vascular Biology Center, Department of Obstetrics and Gynecology, Medical College of Georgia, Assistant Professor1998 - 2002 Huntsman Cancer Institute, University of Utah, Postdoctoral Research1995 - 1998 Department of Molecular and Human Genetics, Baylor College of Medicine, Postdoctoral Research1991 - 1995 PhD Dissertation: The molecular and genetic characterization of the MADS box transcription factor Drosophila MEF2

2020 - Present Department of Pediatrics, The Ohio State University Medical Center, Professor

Contact Information

Call us at: (614)355.5750

Fax us at: (614)355-5725

                    Abigail Wexner Research Institute700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Call us at: (614)355.5750

Fax us at: (614)355-5725

                    Abigail Wexner Research Institute700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Call us at: (614)355.5750

Fax us at: (614)355-5725

                    Abigail Wexner Research Institute700 Children's DriveColumbus, OH 43205 (map)

Call us at: (614)355.5750

Fax us at: (614)355-5725

                    Abigail Wexner Research Institute700 Children's DriveColumbus, OH 43205 (map)

Call us at: (614)355.5750

Fax us at: (614)355-5725

                    Abigail Wexner Research Institute700 Children's DriveColumbus, OH 43205 (map)

Call us at: (614)355.5750

Fax us at: (614)355-5725

                    Abigail Wexner Research Institute700 Children's DriveColumbus, OH 43205 (map)