Contact Information

Call us at: (614) 722-3624

Fax us at: (614) 722-4541

PediatricsNeonatology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Bernadette Chen

Biography

Bernadette Chen, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She is also an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. Dr. Chen’s interests are in the Adenylate Cyclase-cAMP-Phosphodiesterase 3 pathway and its role in persistent pulmonary hypertension of the newborn (PPHN). Both cyclic AMP and cyclic GMP are second messengers in the pulmonary vasculature. There has been a primary focus on cGMP in the pulmonary vasculature, however, cAMP may also be a key factor in promoting pulmonary vasodilation. Adenylate cyclase is responsible for the production of cAMP, while PDE3 degrades both cAMP and cGMP. Although PDE3 has high affinities for both cyclic nucleotides, the rate at which PDE3 hydrolyzes cAMP is much greater. It is known that the vascular effects of cGMP are not only mediated through the activation of protein kinase G, but also through inhibition of PDE3. Therefore, understanding the regulation of this complex pathway may allow for a better understanding of the pulmonary vascular response to different modalities, such as oxygen and nitric oxide, as well as the development of new strategies in the treatment of PPHN.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Chinese

Academic and Clinical Areas

Neonatology

Physician Team

Center for Perinatal Research

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Neonatology

Research

Lab(s)

Center for Perinatal Research

Publications

                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Ball MK, Seabrook RB, Bonachea EM, Chen B, Fathi O, Nankervis CA, Osman A, Schlegel AB, Magers J, Kulpa T, Sharpin P, Snyder ML, Gajarski RJ, Nandi D, Backes CH. Evidence-Based Guidelines for Acute Stabilization and Management of Neonates with Persistent Pulmonary Hypertension of the Newborn. Am J Perinatol. 2021 Dec 1;  

                


                  Dillard J, Pavlek LR, Korada S, Chen B. Worsened short-term clinical outcomes in a cohort of patients with iNO-unresponsive PPHN: a case for improving iNO responsiveness. J Perinatol. 2021 Oct 15;  

                


                  Zettler E, Rivera BK, Stiver C, Boe B, Cua C, Ball MK, Smith CV, Slaughter JL, Chen B, Callahan R, Backes CH. Primary pulmonary vein stenosis among premature infants with single-vessel disease. J Perinatol. 2021 Jul; 41: 1621-1626.

                


                  Dillard J, Meng X, Nelin L, Liu Y, Chen B. Nitric oxide activates AMPK by modulating PDE3A in human pulmonary artery smooth muscle cells. Physiol Rep. 2020 Sep; 8: e14559.

                


                  Dillard J, Perez M, Chen B. Therapies that enhance pulmonary vascular NO-signaling in the neonate. Nitric Oxide. 2020 Feb 1; 95: 45-54.

                


                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

                


                  White HA, Jin Y, Chicoine LG, Chen B, Liu Y, Nelin LD. Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2017 May 1; 312: L649-L656.

                


                  Xue J, Nelin LD, Chen B. Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPKa1 signaling. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1; 312: L568-L578.

                


                  Durrani-Kolarik S, Manickam K, Chen B. COL4A1 Mutation in a Neonate With Intrauterine Stroke and Anterior Segment Dysgenesis. Pediatr Neurol. 2017 Jan; 66: 100-103.

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 09/01/2007

Board Certifications

Neonatal-Perinatal Medicine Pediatrics

Fellowship

Childrens Memorial Hospital (Chicago)

Date Completed: 06/30/2007

Residency

Advocate Christ Hospital and Medical Center - Oakl

Date Completed: 06/30/2004

Medical School

Northeastern Ohio Universities College of Medicine

Date Completed: 05/31/2001

Professional Experience

2007 - Present Pediatric Academic Association/The Ohio State University, Assistant Professor

Contact Information

Pediatrics

Call us at: (614) 722-3624

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-3624

Fax us at: (614) 722-4541

PediatricsNeonatology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Bernadette Chen

Biography

Bernadette Chen, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She is also an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. Dr. Chen’s interests are in the Adenylate Cyclase-cAMP-Phosphodiesterase 3 pathway and its role in persistent pulmonary hypertension of the newborn (PPHN). Both cyclic AMP and cyclic GMP are second messengers in the pulmonary vasculature. There has been a primary focus on cGMP in the pulmonary vasculature, however, cAMP may also be a key factor in promoting pulmonary vasodilation. Adenylate cyclase is responsible for the production of cAMP, while PDE3 degrades both cAMP and cGMP. Although PDE3 has high affinities for both cyclic nucleotides, the rate at which PDE3 hydrolyzes cAMP is much greater. It is known that the vascular effects of cGMP are not only mediated through the activation of protein kinase G, but also through inhibition of PDE3. Therefore, understanding the regulation of this complex pathway may allow for a better understanding of the pulmonary vascular response to different modalities, such as oxygen and nitric oxide, as well as the development of new strategies in the treatment of PPHN.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Chinese

Academic and Clinical Areas

Neonatology

Physician Team

Center for Perinatal Research

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Neonatology

Research

Lab(s)

Center for Perinatal Research

Publications

                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Ball MK, Seabrook RB, Bonachea EM, Chen B, Fathi O, Nankervis CA, Osman A, Schlegel AB, Magers J, Kulpa T, Sharpin P, Snyder ML, Gajarski RJ, Nandi D, Backes CH. Evidence-Based Guidelines for Acute Stabilization and Management of Neonates with Persistent Pulmonary Hypertension of the Newborn. Am J Perinatol. 2021 Dec 1;  

                


                  Dillard J, Pavlek LR, Korada S, Chen B. Worsened short-term clinical outcomes in a cohort of patients with iNO-unresponsive PPHN: a case for improving iNO responsiveness. J Perinatol. 2021 Oct 15;  

                


                  Zettler E, Rivera BK, Stiver C, Boe B, Cua C, Ball MK, Smith CV, Slaughter JL, Chen B, Callahan R, Backes CH. Primary pulmonary vein stenosis among premature infants with single-vessel disease. J Perinatol. 2021 Jul; 41: 1621-1626.

                


                  Dillard J, Meng X, Nelin L, Liu Y, Chen B. Nitric oxide activates AMPK by modulating PDE3A in human pulmonary artery smooth muscle cells. Physiol Rep. 2020 Sep; 8: e14559.

                


                  Dillard J, Perez M, Chen B. Therapies that enhance pulmonary vascular NO-signaling in the neonate. Nitric Oxide. 2020 Feb 1; 95: 45-54.

                


                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

                


                  White HA, Jin Y, Chicoine LG, Chen B, Liu Y, Nelin LD. Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2017 May 1; 312: L649-L656.

                


                  Xue J, Nelin LD, Chen B. Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPKa1 signaling. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1; 312: L568-L578.

                


                  Durrani-Kolarik S, Manickam K, Chen B. COL4A1 Mutation in a Neonate With Intrauterine Stroke and Anterior Segment Dysgenesis. Pediatr Neurol. 2017 Jan; 66: 100-103.

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 09/01/2007

Board Certifications

Neonatal-Perinatal Medicine Pediatrics

Fellowship

Childrens Memorial Hospital (Chicago)

Date Completed: 06/30/2007

Residency

Advocate Christ Hospital and Medical Center - Oakl

Date Completed: 06/30/2004

Medical School

Northeastern Ohio Universities College of Medicine

Date Completed: 05/31/2001

Professional Experience

2007 - Present Pediatric Academic Association/The Ohio State University, Assistant Professor

Contact Information

Pediatrics

Call us at: (614) 722-3624

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 722-3624

Fax us at: (614) 722-4541

PediatricsNeonatology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Bernadette Chen

Contact Information

  • Call us at:
  • (614) 722-3624
  • Fax us at:
  • (614) 722-4541
  • PediatricsNeonatology700 Children’s DrColumbus, OH 43205 (map)

Learn more about Bernadette Chen

Biography

Bernadette Chen, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She is also an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. Dr. Chen’s interests are in the Adenylate Cyclase-cAMP-Phosphodiesterase 3 pathway and its role in persistent pulmonary hypertension of the newborn (PPHN). Both cyclic AMP and cyclic GMP are second messengers in the pulmonary vasculature. There has been a primary focus on cGMP in the pulmonary vasculature, however, cAMP may also be a key factor in promoting pulmonary vasodilation. Adenylate cyclase is responsible for the production of cAMP, while PDE3 degrades both cAMP and cGMP. Although PDE3 has high affinities for both cyclic nucleotides, the rate at which PDE3 hydrolyzes cAMP is much greater. It is known that the vascular effects of cGMP are not only mediated through the activation of protein kinase G, but also through inhibition of PDE3. Therefore, understanding the regulation of this complex pathway may allow for a better understanding of the pulmonary vascular response to different modalities, such as oxygen and nitric oxide, as well as the development of new strategies in the treatment of PPHN.

Biography

Bernadette Chen, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She is also an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. Dr. Chen’s interests are in the Adenylate Cyclase-cAMP-Phosphodiesterase 3 pathway and its role in persistent pulmonary hypertension of the newborn (PPHN). Both cyclic AMP and cyclic GMP are second messengers in the pulmonary vasculature. There has been a primary focus on cGMP in the pulmonary vasculature, however, cAMP may also be a key factor in promoting pulmonary vasodilation. Adenylate cyclase is responsible for the production of cAMP, while PDE3 degrades both cAMP and cGMP. Although PDE3 has high affinities for both cyclic nucleotides, the rate at which PDE3 hydrolyzes cAMP is much greater. It is known that the vascular effects of cGMP are not only mediated through the activation of protein kinase G, but also through inhibition of PDE3. Therefore, understanding the regulation of this complex pathway may allow for a better understanding of the pulmonary vascular response to different modalities, such as oxygen and nitric oxide, as well as the development of new strategies in the treatment of PPHN.

Biography

Bernadette Chen, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She is also an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. Dr. Chen’s interests are in the Adenylate Cyclase-cAMP-Phosphodiesterase 3 pathway and its role in persistent pulmonary hypertension of the newborn (PPHN). Both cyclic AMP and cyclic GMP are second messengers in the pulmonary vasculature. There has been a primary focus on cGMP in the pulmonary vasculature, however, cAMP may also be a key factor in promoting pulmonary vasodilation. Adenylate cyclase is responsible for the production of cAMP, while PDE3 degrades both cAMP and cGMP. Although PDE3 has high affinities for both cyclic nucleotides, the rate at which PDE3 hydrolyzes cAMP is much greater. It is known that the vascular effects of cGMP are not only mediated through the activation of protein kinase G, but also through inhibition of PDE3. Therefore, understanding the regulation of this complex pathway may allow for a better understanding of the pulmonary vascular response to different modalities, such as oxygen and nitric oxide, as well as the development of new strategies in the treatment of PPHN.

Bernadette Chen, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She is also an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. Dr. Chen’s interests are in the Adenylate Cyclase-cAMP-Phosphodiesterase 3 pathway and its role in persistent pulmonary hypertension of the newborn (PPHN). Both cyclic AMP and cyclic GMP are second messengers in the pulmonary vasculature. There has been a primary focus on cGMP in the pulmonary vasculature, however, cAMP may also be a key factor in promoting pulmonary vasodilation. Adenylate cyclase is responsible for the production of cAMP, while PDE3 degrades both cAMP and cGMP. Although PDE3 has high affinities for both cyclic nucleotides, the rate at which PDE3 hydrolyzes cAMP is much greater. It is known that the vascular effects of cGMP are not only mediated through the activation of protein kinase G, but also through inhibition of PDE3. Therefore, understanding the regulation of this complex pathway may allow for a better understanding of the pulmonary vascular response to different modalities, such as oxygen and nitric oxide, as well as the development of new strategies in the treatment of PPHN.

Bernadette Chen, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She is also an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. Dr. Chen’s interests are in the Adenylate Cyclase-cAMP-Phosphodiesterase 3 pathway and its role in persistent pulmonary hypertension of the newborn (PPHN). Both cyclic AMP and cyclic GMP are second messengers in the pulmonary vasculature. There has been a primary focus on cGMP in the pulmonary vasculature, however, cAMP may also be a key factor in promoting pulmonary vasodilation. Adenylate cyclase is responsible for the production of cAMP, while PDE3 degrades both cAMP and cGMP. Although PDE3 has high affinities for both cyclic nucleotides, the rate at which PDE3 hydrolyzes cAMP is much greater. It is known that the vascular effects of cGMP are not only mediated through the activation of protein kinase G, but also through inhibition of PDE3. Therefore, understanding the regulation of this complex pathway may allow for a better understanding of the pulmonary vascular response to different modalities, such as oxygen and nitric oxide, as well as the development of new strategies in the treatment of PPHN.

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Chinese

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Chinese

Patient Care

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Chinese

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Chinese

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Chinese

Locations

Main Campus of Nationwide Children’s Hospital

Languages Spoken

English Chinese

  • Main Campus of Nationwide Children’s Hospital

  • English

  • Chinese

Academic and Clinical Areas

Neonatology

Physician Team

Center for Perinatal Research

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Neonatology

Academic and Clinical Areas

Neonatology

Physician Team

Center for Perinatal Research

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Neonatology

Academic and Clinical Areas

Neonatology

Physician Team

Center for Perinatal Research

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Neonatology

Neonatology

Physician Team

Center for Perinatal Research

Principal Investigator

Neonatology Fellowship

Faculty

Primary Department

Pediatrics

Primary Section

Neonatology

  • Neonatology
  • Physician Team
  • Center for Perinatal Research
  • Principal Investigator
  • Neonatology Fellowship
  • Faculty
  • Primary Department
  • Pediatrics
  • Primary Section
  • Neonatology

Research

Lab(s)

Center for Perinatal Research

Publications

                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Ball MK, Seabrook RB, Bonachea EM, Chen B, Fathi O, Nankervis CA, Osman A, Schlegel AB, Magers J, Kulpa T, Sharpin P, Snyder ML, Gajarski RJ, Nandi D, Backes CH. Evidence-Based Guidelines for Acute Stabilization and Management of Neonates with Persistent Pulmonary Hypertension of the Newborn. Am J Perinatol. 2021 Dec 1;  

                


                  Dillard J, Pavlek LR, Korada S, Chen B. Worsened short-term clinical outcomes in a cohort of patients with iNO-unresponsive PPHN: a case for improving iNO responsiveness. J Perinatol. 2021 Oct 15;  

                


                  Zettler E, Rivera BK, Stiver C, Boe B, Cua C, Ball MK, Smith CV, Slaughter JL, Chen B, Callahan R, Backes CH. Primary pulmonary vein stenosis among premature infants with single-vessel disease. J Perinatol. 2021 Jul; 41: 1621-1626.

                


                  Dillard J, Meng X, Nelin L, Liu Y, Chen B. Nitric oxide activates AMPK by modulating PDE3A in human pulmonary artery smooth muscle cells. Physiol Rep. 2020 Sep; 8: e14559.

                


                  Dillard J, Perez M, Chen B. Therapies that enhance pulmonary vascular NO-signaling in the neonate. Nitric Oxide. 2020 Feb 1; 95: 45-54.

                


                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

                


                  White HA, Jin Y, Chicoine LG, Chen B, Liu Y, Nelin LD. Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2017 May 1; 312: L649-L656.

                


                  Xue J, Nelin LD, Chen B. Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPKa1 signaling. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1; 312: L568-L578.

                


                  Durrani-Kolarik S, Manickam K, Chen B. COL4A1 Mutation in a Neonate With Intrauterine Stroke and Anterior Segment Dysgenesis. Pediatr Neurol. 2017 Jan; 66: 100-103.

View More Publications

Research

Lab(s)

Center for Perinatal Research

Publications

                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Ball MK, Seabrook RB, Bonachea EM, Chen B, Fathi O, Nankervis CA, Osman A, Schlegel AB, Magers J, Kulpa T, Sharpin P, Snyder ML, Gajarski RJ, Nandi D, Backes CH. Evidence-Based Guidelines for Acute Stabilization and Management of Neonates with Persistent Pulmonary Hypertension of the Newborn. Am J Perinatol. 2021 Dec 1;  

                


                  Dillard J, Pavlek LR, Korada S, Chen B. Worsened short-term clinical outcomes in a cohort of patients with iNO-unresponsive PPHN: a case for improving iNO responsiveness. J Perinatol. 2021 Oct 15;  

                


                  Zettler E, Rivera BK, Stiver C, Boe B, Cua C, Ball MK, Smith CV, Slaughter JL, Chen B, Callahan R, Backes CH. Primary pulmonary vein stenosis among premature infants with single-vessel disease. J Perinatol. 2021 Jul; 41: 1621-1626.

                


                  Dillard J, Meng X, Nelin L, Liu Y, Chen B. Nitric oxide activates AMPK by modulating PDE3A in human pulmonary artery smooth muscle cells. Physiol Rep. 2020 Sep; 8: e14559.

                


                  Dillard J, Perez M, Chen B. Therapies that enhance pulmonary vascular NO-signaling in the neonate. Nitric Oxide. 2020 Feb 1; 95: 45-54.

                


                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

                


                  White HA, Jin Y, Chicoine LG, Chen B, Liu Y, Nelin LD. Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2017 May 1; 312: L649-L656.

                


                  Xue J, Nelin LD, Chen B. Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPKa1 signaling. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1; 312: L568-L578.

                


                  Durrani-Kolarik S, Manickam K, Chen B. COL4A1 Mutation in a Neonate With Intrauterine Stroke and Anterior Segment Dysgenesis. Pediatr Neurol. 2017 Jan; 66: 100-103.

View More Publications

Research

Lab(s)

Center for Perinatal Research

Publications

                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Ball MK, Seabrook RB, Bonachea EM, Chen B, Fathi O, Nankervis CA, Osman A, Schlegel AB, Magers J, Kulpa T, Sharpin P, Snyder ML, Gajarski RJ, Nandi D, Backes CH. Evidence-Based Guidelines for Acute Stabilization and Management of Neonates with Persistent Pulmonary Hypertension of the Newborn. Am J Perinatol. 2021 Dec 1;  

                


                  Dillard J, Pavlek LR, Korada S, Chen B. Worsened short-term clinical outcomes in a cohort of patients with iNO-unresponsive PPHN: a case for improving iNO responsiveness. J Perinatol. 2021 Oct 15;  

                


                  Zettler E, Rivera BK, Stiver C, Boe B, Cua C, Ball MK, Smith CV, Slaughter JL, Chen B, Callahan R, Backes CH. Primary pulmonary vein stenosis among premature infants with single-vessel disease. J Perinatol. 2021 Jul; 41: 1621-1626.

                


                  Dillard J, Meng X, Nelin L, Liu Y, Chen B. Nitric oxide activates AMPK by modulating PDE3A in human pulmonary artery smooth muscle cells. Physiol Rep. 2020 Sep; 8: e14559.

                


                  Dillard J, Perez M, Chen B. Therapies that enhance pulmonary vascular NO-signaling in the neonate. Nitric Oxide. 2020 Feb 1; 95: 45-54.

                


                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

                


                  White HA, Jin Y, Chicoine LG, Chen B, Liu Y, Nelin LD. Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2017 May 1; 312: L649-L656.

                


                  Xue J, Nelin LD, Chen B. Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPKa1 signaling. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1; 312: L568-L578.

                


                  Durrani-Kolarik S, Manickam K, Chen B. COL4A1 Mutation in a Neonate With Intrauterine Stroke and Anterior Segment Dysgenesis. Pediatr Neurol. 2017 Jan; 66: 100-103.

View More Publications

Lab(s)

Center for Perinatal Research

Publications

                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Ball MK, Seabrook RB, Bonachea EM, Chen B, Fathi O, Nankervis CA, Osman A, Schlegel AB, Magers J, Kulpa T, Sharpin P, Snyder ML, Gajarski RJ, Nandi D, Backes CH. Evidence-Based Guidelines for Acute Stabilization and Management of Neonates with Persistent Pulmonary Hypertension of the Newborn. Am J Perinatol. 2021 Dec 1;  

                


                  Dillard J, Pavlek LR, Korada S, Chen B. Worsened short-term clinical outcomes in a cohort of patients with iNO-unresponsive PPHN: a case for improving iNO responsiveness. J Perinatol. 2021 Oct 15;  

                


                  Zettler E, Rivera BK, Stiver C, Boe B, Cua C, Ball MK, Smith CV, Slaughter JL, Chen B, Callahan R, Backes CH. Primary pulmonary vein stenosis among premature infants with single-vessel disease. J Perinatol. 2021 Jul; 41: 1621-1626.

                


                  Dillard J, Meng X, Nelin L, Liu Y, Chen B. Nitric oxide activates AMPK by modulating PDE3A in human pulmonary artery smooth muscle cells. Physiol Rep. 2020 Sep; 8: e14559.

                


                  Dillard J, Perez M, Chen B. Therapies that enhance pulmonary vascular NO-signaling in the neonate. Nitric Oxide. 2020 Feb 1; 95: 45-54.

                


                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

                


                  White HA, Jin Y, Chicoine LG, Chen B, Liu Y, Nelin LD. Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2017 May 1; 312: L649-L656.

                


                  Xue J, Nelin LD, Chen B. Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPKa1 signaling. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1; 312: L568-L578.

                


                  Durrani-Kolarik S, Manickam K, Chen B. COL4A1 Mutation in a Neonate With Intrauterine Stroke and Anterior Segment Dysgenesis. Pediatr Neurol. 2017 Jan; 66: 100-103.

View More Publications

Lab(s)

Center for Perinatal Research

                  Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13;  101938.

                


                  Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;  

                


                  Ball MK, Seabrook RB, Bonachea EM, Chen B, Fathi O, Nankervis CA, Osman A, Schlegel AB, Magers J, Kulpa T, Sharpin P, Snyder ML, Gajarski RJ, Nandi D, Backes CH. Evidence-Based Guidelines for Acute Stabilization and Management of Neonates with Persistent Pulmonary Hypertension of the Newborn. Am J Perinatol. 2021 Dec 1;  

                


                  Dillard J, Pavlek LR, Korada S, Chen B. Worsened short-term clinical outcomes in a cohort of patients with iNO-unresponsive PPHN: a case for improving iNO responsiveness. J Perinatol. 2021 Oct 15;  

                


                  Zettler E, Rivera BK, Stiver C, Boe B, Cua C, Ball MK, Smith CV, Slaughter JL, Chen B, Callahan R, Backes CH. Primary pulmonary vein stenosis among premature infants with single-vessel disease. J Perinatol. 2021 Jul; 41: 1621-1626.

                


                  Dillard J, Meng X, Nelin L, Liu Y, Chen B. Nitric oxide activates AMPK by modulating PDE3A in human pulmonary artery smooth muscle cells. Physiol Rep. 2020 Sep; 8: e14559.

                


                  Dillard J, Perez M, Chen B. Therapies that enhance pulmonary vascular NO-signaling in the neonate. Nitric Oxide. 2020 Feb 1; 95: 45-54.

                


                  Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

                


                  White HA, Jin Y, Chicoine LG, Chen B, Liu Y, Nelin LD. Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2017 May 1; 312: L649-L656.

                


                  Xue J, Nelin LD, Chen B. Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPKa1 signaling. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1; 312: L568-L578.

                


                  Durrani-Kolarik S, Manickam K, Chen B. COL4A1 Mutation in a Neonate With Intrauterine Stroke and Anterior Segment Dysgenesis. Pediatr Neurol. 2017 Jan; 66: 100-103.

View More Publications

Lab(s)

Center for Perinatal Research

  • Center for Perinatal Research

  • Barley TJ, Murphy PR, Wang X, Bowman BA, Mormol JM, Mager CE, Kirk SG, Cash CJ, Linn SC, Meng X, Nelin LD, Chen B, Hafner M, Zhang J, Liu Y. Mitogen-Activated Protein Kinase Phosphatase-1 Controls PD-L1 Expression by Regulating Type I Interferon during Systemic Escherichia coli Infection. J Biol Chem. 2022 Apr 13; 101938.

  • Nelin LD, Jin Y, Chen B, Liu Y, Rogers LK, Reese J. Cyclooxygenase-2 Deficiency Attenuates Lipopolysaccharide-induced Inflammation, Apoptosis and Acute Lung Injury in Adult Mice. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 5;

  • Ball MK, Seabrook RB, Bonachea EM, Chen B, Fathi O, Nankervis CA, Osman A, Schlegel AB, Magers J, Kulpa T, Sharpin P, Snyder ML, Gajarski RJ, Nandi D, Backes CH. Evidence-Based Guidelines for Acute Stabilization and Management of Neonates with Persistent Pulmonary Hypertension of the Newborn. Am J Perinatol. 2021 Dec 1;

  • Dillard J, Pavlek LR, Korada S, Chen B. Worsened short-term clinical outcomes in a cohort of patients with iNO-unresponsive PPHN: a case for improving iNO responsiveness. J Perinatol. 2021 Oct 15;

  • Zettler E, Rivera BK, Stiver C, Boe B, Cua C, Ball MK, Smith CV, Slaughter JL, Chen B, Callahan R, Backes CH. Primary pulmonary vein stenosis among premature infants with single-vessel disease. J Perinatol. 2021 Jul; 41: 1621-1626.

  • Dillard J, Meng X, Nelin L, Liu Y, Chen B. Nitric oxide activates AMPK by modulating PDE3A in human pulmonary artery smooth muscle cells. Physiol Rep. 2020 Sep; 8: e14559.

  • Dillard J, Perez M, Chen B. Therapies that enhance pulmonary vascular NO-signaling in the neonate. Nitric Oxide. 2020 Feb 1; 95: 45-54.

  • Pool CM, Jin Y, Chen B, Liu Y, Nelin LD. Hypoxic-induction of arginase II requires EGF-mediated EGFR activation in human pulmonary microvascular endothelial cells. Physiol Rep. 2018 May; 6: e13693.

  • White HA, Jin Y, Chicoine LG, Chen B, Liu Y, Nelin LD. Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol. 2017 May 1; 312: L649-L656.

  • Xue J, Nelin LD, Chen B. Hypoxia induces arginase II expression and increases viable human pulmonary artery smooth muscle cell numbers via AMPKa1 signaling. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1; 312: L568-L578.

  • Durrani-Kolarik S, Manickam K, Chen B. COL4A1 Mutation in a Neonate With Intrauterine Stroke and Anterior Segment Dysgenesis. Pediatr Neurol. 2017 Jan; 66: 100-103.

Education

Date of Appointment at Nationwide Children’s Hospital: 09/01/2007

Board Certifications

Neonatal-Perinatal Medicine Pediatrics

Fellowship

Childrens Memorial Hospital (Chicago)

Date Completed: 06/30/2007

Residency

Advocate Christ Hospital and Medical Center - Oakl

Date Completed: 06/30/2004

Medical School

Northeastern Ohio Universities College of Medicine

Date Completed: 05/31/2001

Education

Date of Appointment at Nationwide Children’s Hospital: 09/01/2007

Board Certifications

Neonatal-Perinatal Medicine Pediatrics

Fellowship

Childrens Memorial Hospital (Chicago)

Date Completed: 06/30/2007

Residency

Advocate Christ Hospital and Medical Center - Oakl

Date Completed: 06/30/2004

Medical School

Northeastern Ohio Universities College of Medicine

Date Completed: 05/31/2001

Education

Date of Appointment at Nationwide Children’s Hospital: 09/01/2007

Board Certifications

Neonatal-Perinatal Medicine Pediatrics

Fellowship

Childrens Memorial Hospital (Chicago)

Date Completed: 06/30/2007

Residency

Advocate Christ Hospital and Medical Center - Oakl

Date Completed: 06/30/2004

Medical School

Northeastern Ohio Universities College of Medicine

Date Completed: 05/31/2001

Date of Appointment at Nationwide Children’s Hospital: 09/01/2007

Board Certifications

Neonatal-Perinatal Medicine Pediatrics

Fellowship

Childrens Memorial Hospital (Chicago)

Date Completed: 06/30/2007

Residency

Advocate Christ Hospital and Medical Center - Oakl

Date Completed: 06/30/2004

Medical School

Northeastern Ohio Universities College of Medicine

Date Completed: 05/31/2001

Date of Appointment at Nationwide Children’s Hospital: 09/01/2007

Board Certifications

Neonatal-Perinatal Medicine Pediatrics

Fellowship

Childrens Memorial Hospital (Chicago)

Date Completed: 06/30/2007

Residency

Advocate Christ Hospital and Medical Center - Oakl

Date Completed: 06/30/2004

Medical School

Northeastern Ohio Universities College of Medicine

Date Completed: 05/31/2001

  • Neonatal-Perinatal Medicine
  • Pediatrics

Professional Experience

2007 - Present Pediatric Academic Association/The Ohio State University, Assistant Professor

Professional Experience

2007 - Present Pediatric Academic Association/The Ohio State University, Assistant Professor

Professional Experience

2007 - Present Pediatric Academic Association/The Ohio State University, Assistant Professor

2007 - Present Pediatric Academic Association/The Ohio State University, Assistant Professor

2007 - Present Pediatric Academic Association/The Ohio State University, Assistant Professor

Contact Information

Pediatrics

Call us at: (614) 722-3624

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pediatrics

Call us at: (614) 722-3624

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Contact Information

Pediatrics

Call us at: (614) 722-3624

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Pediatrics

Call us at: (614) 722-3624

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-3624

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)

Call us at: (614) 722-3624

Fax us at: (614) 722-4541

                    Neonatology700 Children's DrColumbus, OH 43205 (map)
  • Call us at:
  • (614) 722-3624
  • Fax us at:
  • (614) 722-4541
  • Neonatology700 Children’s DrColumbus, OH 43205 (map)