Benjamin Stanton

Contact Information

Call us at: (301) 613-9390

Email Benjamin Stanton, PhD

Center for Childhood Cancer700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Benjamin Stanton

Research

Lab(s)

Center for Childhood Cancer

Ben Stanton, PhD, is a principal investigator in the Center for Childhood Cancer at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, and assistant professor at The Ohio State University College of Medicine. Ben received his PhD from Harvard University, and Postdoctoral training at Stanford University School of Medicine and NIH. His group studies chromatin activation and epigenetic repression at the systems level, to gain insight into genome architecture in childhood cancers. He is motivated to understand the essential roles of chromatin regulatory complexes in low mutational burden tumors. For studies in the lab, interdisciplinary approaches are developed to ask (1) how aberrant chromatin repression can drive human disease, (2) why chromatin remodeling is under positive selection in certain pediatric tumors, and (3) whether new methods can enable insights into chromatin deregulation. Ben is excited about mentoring next-generation of scientist and for fundamental insights that enable translational advances. Publications

                  Masih KE, Gardner RA, Chou HC, Abdelmaksoud A, Song YK, Mariani L, Gangalapudi V, Gryder BE, Wilson AL, Adebola SO, Stanton BZ, Wang C, Milewski D, Kim YY, Tian M, Cheuk AT, Wen X, Zhang Y, Altan-Bonnet G, Kelly MC, Wei JS, Bulyk ML, Jensen MC, Orentas RJ, Khan J. A stem cell epigenome is associated with primary nonresponse to CD19 CAR T-cells in pediatric acute lymphoblastic leukemia. Blood Adv. 2023 Jan 6;  

                


                  Wang M, Sunkel BD, Ray WC, Stanton BZ. Chromatin structure in cancer. BMC Mol Cell Biol. 2022 Jul 28; 23: 35.

                


                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.

                


                  Popova LV, Nagarajan P, Lovejoy CM, Sunkel BD, Gardner ML, Wang M, Freitas MA, Stanton BZ, Parthun MR. Epigenetic regulation of nuclear lamina-associated heterochromatin by HAT1 and the acetylation of newly synthesized histones. Nucleic Acids Res. 2021 Dec 2; 49: 12136-12151.

                


                  Laubscher D, Gryder BE, Sunkel BD, Andresson T, Wachtel M, Das S, Roschitzki B, Wolski W, Wu XS, Chou HC, Song YK, Wang C, Wei JS, Wang M, Wen X, Ngo QA, Marques JG, Vakoc CR, Schäfer BW, Stanton BZ, Khan J. BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma. Nat Commun. 2021 Nov 26; 12: 6924.

                


                  Wang L, Hensch NR, Bondra K, Sreenivas P, Zhao XR, Chen J, Moreno Campos R, Baxi K, Vaseva AV, Sunkel BD, Gryder BE, Pomella S, Stanton BZ, Zheng S, Chen EY, Rota R, Khan J, Houghton PJ, Ignatius MS. SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation. Cancer Res. 2021 Nov 1; 81: 5451-5463.

                


                  Sunkel BD, Stanton BZ. Pioneer factors in development and cancer. iScience. 2021 Oct 22; 24: 103132.

                


                  Sunkel BD, Wang M, LaHaye S, Kelly BJ, Fitch JR, Barr FG, White P, Stanton BZ. Evidence of pioneer factor activity of an oncogenic fusion transcription factor. iScience. 2021 Aug 20; 24: 102867.

                


                  Tallan A, Stanton BZ. Inducible Protein Degradation to Understand Genome Architecture. Biochemistry. 2021 Aug 10; 60: 2387-2396.

                


                  Boone MA, Taslim C, Crow JC, Selich-Anderson J, Byrum AK, Showpnil IA, Sunkel BD, Wang M, Stanton BZ, Theisen ER, Lessnick SL. The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma. Oncogene. 2021 Jul; 40: 4759-4769.

                


                  Weber CM, Hafner A, Kirkland JG, Braun SMG, Stanton BZ, Boettiger AN, Crabtree GR. mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution. Nat Struct Mol Biol. 2021 Jun; 28: 501-511.

                


                  Pomella S, Sreenivas P, Gryder BE, Wang L, Milewski D, Cassandri M, Baxi K, Hensch NR, Carcarino E, Song Y, Chou HC, Yohe ME, Stanton BZ, Amadio B, Caruana I, De Stefanis C, De Vito R, Locatelli F, Chen Y, Chen EY, Houghton P, Khan J, Rota R, Ignatius MS. Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma. Nat Commun. 2021 Jan 8; 12: 192.

                


                  Gryder BE, Wachtel M, Chang K, El Demerdash O, Aboreden NG, Mohammed W, Ewert W, Pomella S, Rota R, Wei JS, Song Y, Stanton BZ, Schäfer B, Vakoc CR, Khan J. Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage. iScience. 2020 May 22; 23: 101103.

                


                  Gryder BE, Khan J, Stanton BZ. Measurement of differential chromatin interactions with absolute quantification of architecture (AQuA-HiChIP). Nat Protoc. 2020 Mar; 15: 1209-1236.

                


                  Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, Vakoc CR, Shern JF, Stanton BZ, Khan J. Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma. Nat Genet. 2019 Dec; 51: 1714-1722.

                


                  Lin GL, Wilson KM, Ceribelli M, Stanton BZ, Woo PJ, Kreimer S, Qin EY, Zhang X, Lennon J, Nagaraja S, Morris PJ, Quezada M, Gillespie SM, Duveau DY, Michalowski AM, Shinn P, Guha R, Ferrer M, Klumpp-Thomas C, Michael S, McKnight C, Minhas P, Itkin Z, Raabe EH, Chen L, Ghanem R, Geraghty AC, Ni L, Andreasson KI, Vitanza NA, Warren KE, Thomas CJ, Monje M. Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening. Sci Transl Med. 2019 Nov 20; 11: 

                


                  Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O, Frye SV. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Oct 17; 26: 1365-1379.e22.

                


                  Gryder BE, Wu L, Woldemichael GM, Pomella S, Quinn TR, Park PMC, Cleveland A, Stanton BZ, Song Y, Rota R, Wiest O, Yohe ME, Shern JF, Qi J, Khan J. Chemical genomics reveals histone deacetylases are required for core regulatory transcription. Nat Commun. 2019 Jul 8; 10: 3004.

                


                  Lai B, Tang Q, Jin W, Hu G, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. Trac-looping measures genome structure and chromatin accessibility. Nat Methods. 2018 Sep; 15: 741-747.

                


                  Stanton BZ, Chory EJ, Crabtree GR. Chemically induced proximity in biology and medicine. Science. 2018 Mar 9; 359: 

                


                  Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nat Struct Mol Biol. 2018 Jan; 25: 61-72.

View More Publications

Academic and Clinical Areas

Center for Childhood Cancer

Principal Investigator

Primary Department

Center for Childhood Cancer

Awards, Honors & Organizations

St. Baldrick’s Scholar Award, 2019 NIH National Center for Advancing Translational Sciences Director’s Award, 2018

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2019

Graduate School

Harvard University

Date Completed: 06/04/2009

Contact Information

Center for Childhood Cancer

Call us at: (301) 613-9390

Email Benjamin Stanton

                    700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Call us at: (301) 613-9390

Email Benjamin Stanton, PhD

Center for Childhood Cancer700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Benjamin Stanton

Research

Lab(s)

Center for Childhood Cancer

Ben Stanton, PhD, is a principal investigator in the Center for Childhood Cancer at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, and assistant professor at The Ohio State University College of Medicine. Ben received his PhD from Harvard University, and Postdoctoral training at Stanford University School of Medicine and NIH. His group studies chromatin activation and epigenetic repression at the systems level, to gain insight into genome architecture in childhood cancers. He is motivated to understand the essential roles of chromatin regulatory complexes in low mutational burden tumors. For studies in the lab, interdisciplinary approaches are developed to ask (1) how aberrant chromatin repression can drive human disease, (2) why chromatin remodeling is under positive selection in certain pediatric tumors, and (3) whether new methods can enable insights into chromatin deregulation. Ben is excited about mentoring next-generation of scientist and for fundamental insights that enable translational advances. Publications

                  Masih KE, Gardner RA, Chou HC, Abdelmaksoud A, Song YK, Mariani L, Gangalapudi V, Gryder BE, Wilson AL, Adebola SO, Stanton BZ, Wang C, Milewski D, Kim YY, Tian M, Cheuk AT, Wen X, Zhang Y, Altan-Bonnet G, Kelly MC, Wei JS, Bulyk ML, Jensen MC, Orentas RJ, Khan J. A stem cell epigenome is associated with primary nonresponse to CD19 CAR T-cells in pediatric acute lymphoblastic leukemia. Blood Adv. 2023 Jan 6;  

                


                  Wang M, Sunkel BD, Ray WC, Stanton BZ. Chromatin structure in cancer. BMC Mol Cell Biol. 2022 Jul 28; 23: 35.

                


                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.

                


                  Popova LV, Nagarajan P, Lovejoy CM, Sunkel BD, Gardner ML, Wang M, Freitas MA, Stanton BZ, Parthun MR. Epigenetic regulation of nuclear lamina-associated heterochromatin by HAT1 and the acetylation of newly synthesized histones. Nucleic Acids Res. 2021 Dec 2; 49: 12136-12151.

                


                  Laubscher D, Gryder BE, Sunkel BD, Andresson T, Wachtel M, Das S, Roschitzki B, Wolski W, Wu XS, Chou HC, Song YK, Wang C, Wei JS, Wang M, Wen X, Ngo QA, Marques JG, Vakoc CR, Schäfer BW, Stanton BZ, Khan J. BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma. Nat Commun. 2021 Nov 26; 12: 6924.

                


                  Wang L, Hensch NR, Bondra K, Sreenivas P, Zhao XR, Chen J, Moreno Campos R, Baxi K, Vaseva AV, Sunkel BD, Gryder BE, Pomella S, Stanton BZ, Zheng S, Chen EY, Rota R, Khan J, Houghton PJ, Ignatius MS. SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation. Cancer Res. 2021 Nov 1; 81: 5451-5463.

                


                  Sunkel BD, Stanton BZ. Pioneer factors in development and cancer. iScience. 2021 Oct 22; 24: 103132.

                


                  Sunkel BD, Wang M, LaHaye S, Kelly BJ, Fitch JR, Barr FG, White P, Stanton BZ. Evidence of pioneer factor activity of an oncogenic fusion transcription factor. iScience. 2021 Aug 20; 24: 102867.

                


                  Tallan A, Stanton BZ. Inducible Protein Degradation to Understand Genome Architecture. Biochemistry. 2021 Aug 10; 60: 2387-2396.

                


                  Boone MA, Taslim C, Crow JC, Selich-Anderson J, Byrum AK, Showpnil IA, Sunkel BD, Wang M, Stanton BZ, Theisen ER, Lessnick SL. The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma. Oncogene. 2021 Jul; 40: 4759-4769.

                


                  Weber CM, Hafner A, Kirkland JG, Braun SMG, Stanton BZ, Boettiger AN, Crabtree GR. mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution. Nat Struct Mol Biol. 2021 Jun; 28: 501-511.

                


                  Pomella S, Sreenivas P, Gryder BE, Wang L, Milewski D, Cassandri M, Baxi K, Hensch NR, Carcarino E, Song Y, Chou HC, Yohe ME, Stanton BZ, Amadio B, Caruana I, De Stefanis C, De Vito R, Locatelli F, Chen Y, Chen EY, Houghton P, Khan J, Rota R, Ignatius MS. Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma. Nat Commun. 2021 Jan 8; 12: 192.

                


                  Gryder BE, Wachtel M, Chang K, El Demerdash O, Aboreden NG, Mohammed W, Ewert W, Pomella S, Rota R, Wei JS, Song Y, Stanton BZ, Schäfer B, Vakoc CR, Khan J. Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage. iScience. 2020 May 22; 23: 101103.

                


                  Gryder BE, Khan J, Stanton BZ. Measurement of differential chromatin interactions with absolute quantification of architecture (AQuA-HiChIP). Nat Protoc. 2020 Mar; 15: 1209-1236.

                


                  Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, Vakoc CR, Shern JF, Stanton BZ, Khan J. Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma. Nat Genet. 2019 Dec; 51: 1714-1722.

                


                  Lin GL, Wilson KM, Ceribelli M, Stanton BZ, Woo PJ, Kreimer S, Qin EY, Zhang X, Lennon J, Nagaraja S, Morris PJ, Quezada M, Gillespie SM, Duveau DY, Michalowski AM, Shinn P, Guha R, Ferrer M, Klumpp-Thomas C, Michael S, McKnight C, Minhas P, Itkin Z, Raabe EH, Chen L, Ghanem R, Geraghty AC, Ni L, Andreasson KI, Vitanza NA, Warren KE, Thomas CJ, Monje M. Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening. Sci Transl Med. 2019 Nov 20; 11: 

                


                  Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O, Frye SV. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Oct 17; 26: 1365-1379.e22.

                


                  Gryder BE, Wu L, Woldemichael GM, Pomella S, Quinn TR, Park PMC, Cleveland A, Stanton BZ, Song Y, Rota R, Wiest O, Yohe ME, Shern JF, Qi J, Khan J. Chemical genomics reveals histone deacetylases are required for core regulatory transcription. Nat Commun. 2019 Jul 8; 10: 3004.

                


                  Lai B, Tang Q, Jin W, Hu G, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. Trac-looping measures genome structure and chromatin accessibility. Nat Methods. 2018 Sep; 15: 741-747.

                


                  Stanton BZ, Chory EJ, Crabtree GR. Chemically induced proximity in biology and medicine. Science. 2018 Mar 9; 359: 

                


                  Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nat Struct Mol Biol. 2018 Jan; 25: 61-72.

View More Publications

Academic and Clinical Areas

Center for Childhood Cancer

Principal Investigator

Primary Department

Center for Childhood Cancer

Awards, Honors & Organizations

St. Baldrick’s Scholar Award, 2019 NIH National Center for Advancing Translational Sciences Director’s Award, 2018

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2019

Graduate School

Harvard University

Date Completed: 06/04/2009

Contact Information

Center for Childhood Cancer

Call us at: (301) 613-9390

Email Benjamin Stanton

                    700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Call us at: (301) 613-9390

Email Benjamin Stanton, PhD

Center for Childhood Cancer700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Benjamin Stanton

Contact Information

• Call us at:
• (301) 613-9390
• Email Benjamin Stanton, PhD
• Center for Childhood Cancer700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Benjamin Stanton

Research

Lab(s)

Center for Childhood Cancer

Ben Stanton, PhD, is a principal investigator in the Center for Childhood Cancer at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, and assistant professor at The Ohio State University College of Medicine. Ben received his PhD from Harvard University, and Postdoctoral training at Stanford University School of Medicine and NIH. His group studies chromatin activation and epigenetic repression at the systems level, to gain insight into genome architecture in childhood cancers. He is motivated to understand the essential roles of chromatin regulatory complexes in low mutational burden tumors. For studies in the lab, interdisciplinary approaches are developed to ask (1) how aberrant chromatin repression can drive human disease, (2) why chromatin remodeling is under positive selection in certain pediatric tumors, and (3) whether new methods can enable insights into chromatin deregulation. Ben is excited about mentoring next-generation of scientist and for fundamental insights that enable translational advances. Publications

                  Masih KE, Gardner RA, Chou HC, Abdelmaksoud A, Song YK, Mariani L, Gangalapudi V, Gryder BE, Wilson AL, Adebola SO, Stanton BZ, Wang C, Milewski D, Kim YY, Tian M, Cheuk AT, Wen X, Zhang Y, Altan-Bonnet G, Kelly MC, Wei JS, Bulyk ML, Jensen MC, Orentas RJ, Khan J. A stem cell epigenome is associated with primary nonresponse to CD19 CAR T-cells in pediatric acute lymphoblastic leukemia. Blood Adv. 2023 Jan 6;  

                


                  Wang M, Sunkel BD, Ray WC, Stanton BZ. Chromatin structure in cancer. BMC Mol Cell Biol. 2022 Jul 28; 23: 35.

                


                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.

                


                  Popova LV, Nagarajan P, Lovejoy CM, Sunkel BD, Gardner ML, Wang M, Freitas MA, Stanton BZ, Parthun MR. Epigenetic regulation of nuclear lamina-associated heterochromatin by HAT1 and the acetylation of newly synthesized histones. Nucleic Acids Res. 2021 Dec 2; 49: 12136-12151.

                


                  Laubscher D, Gryder BE, Sunkel BD, Andresson T, Wachtel M, Das S, Roschitzki B, Wolski W, Wu XS, Chou HC, Song YK, Wang C, Wei JS, Wang M, Wen X, Ngo QA, Marques JG, Vakoc CR, Schäfer BW, Stanton BZ, Khan J. BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma. Nat Commun. 2021 Nov 26; 12: 6924.

                


                  Wang L, Hensch NR, Bondra K, Sreenivas P, Zhao XR, Chen J, Moreno Campos R, Baxi K, Vaseva AV, Sunkel BD, Gryder BE, Pomella S, Stanton BZ, Zheng S, Chen EY, Rota R, Khan J, Houghton PJ, Ignatius MS. SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation. Cancer Res. 2021 Nov 1; 81: 5451-5463.

                


                  Sunkel BD, Stanton BZ. Pioneer factors in development and cancer. iScience. 2021 Oct 22; 24: 103132.

                


                  Sunkel BD, Wang M, LaHaye S, Kelly BJ, Fitch JR, Barr FG, White P, Stanton BZ. Evidence of pioneer factor activity of an oncogenic fusion transcription factor. iScience. 2021 Aug 20; 24: 102867.

                


                  Tallan A, Stanton BZ. Inducible Protein Degradation to Understand Genome Architecture. Biochemistry. 2021 Aug 10; 60: 2387-2396.

                


                  Boone MA, Taslim C, Crow JC, Selich-Anderson J, Byrum AK, Showpnil IA, Sunkel BD, Wang M, Stanton BZ, Theisen ER, Lessnick SL. The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma. Oncogene. 2021 Jul; 40: 4759-4769.

                


                  Weber CM, Hafner A, Kirkland JG, Braun SMG, Stanton BZ, Boettiger AN, Crabtree GR. mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution. Nat Struct Mol Biol. 2021 Jun; 28: 501-511.

                


                  Pomella S, Sreenivas P, Gryder BE, Wang L, Milewski D, Cassandri M, Baxi K, Hensch NR, Carcarino E, Song Y, Chou HC, Yohe ME, Stanton BZ, Amadio B, Caruana I, De Stefanis C, De Vito R, Locatelli F, Chen Y, Chen EY, Houghton P, Khan J, Rota R, Ignatius MS. Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma. Nat Commun. 2021 Jan 8; 12: 192.

                


                  Gryder BE, Wachtel M, Chang K, El Demerdash O, Aboreden NG, Mohammed W, Ewert W, Pomella S, Rota R, Wei JS, Song Y, Stanton BZ, Schäfer B, Vakoc CR, Khan J. Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage. iScience. 2020 May 22; 23: 101103.

                


                  Gryder BE, Khan J, Stanton BZ. Measurement of differential chromatin interactions with absolute quantification of architecture (AQuA-HiChIP). Nat Protoc. 2020 Mar; 15: 1209-1236.

                


                  Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, Vakoc CR, Shern JF, Stanton BZ, Khan J. Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma. Nat Genet. 2019 Dec; 51: 1714-1722.

                


                  Lin GL, Wilson KM, Ceribelli M, Stanton BZ, Woo PJ, Kreimer S, Qin EY, Zhang X, Lennon J, Nagaraja S, Morris PJ, Quezada M, Gillespie SM, Duveau DY, Michalowski AM, Shinn P, Guha R, Ferrer M, Klumpp-Thomas C, Michael S, McKnight C, Minhas P, Itkin Z, Raabe EH, Chen L, Ghanem R, Geraghty AC, Ni L, Andreasson KI, Vitanza NA, Warren KE, Thomas CJ, Monje M. Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening. Sci Transl Med. 2019 Nov 20; 11: 

                


                  Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O, Frye SV. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Oct 17; 26: 1365-1379.e22.

                


                  Gryder BE, Wu L, Woldemichael GM, Pomella S, Quinn TR, Park PMC, Cleveland A, Stanton BZ, Song Y, Rota R, Wiest O, Yohe ME, Shern JF, Qi J, Khan J. Chemical genomics reveals histone deacetylases are required for core regulatory transcription. Nat Commun. 2019 Jul 8; 10: 3004.

                


                  Lai B, Tang Q, Jin W, Hu G, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. Trac-looping measures genome structure and chromatin accessibility. Nat Methods. 2018 Sep; 15: 741-747.

                


                  Stanton BZ, Chory EJ, Crabtree GR. Chemically induced proximity in biology and medicine. Science. 2018 Mar 9; 359: 

                


                  Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nat Struct Mol Biol. 2018 Jan; 25: 61-72.

View More Publications

Research

Lab(s)

Center for Childhood Cancer

Ben Stanton, PhD, is a principal investigator in the Center for Childhood Cancer at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, and assistant professor at The Ohio State University College of Medicine. Ben received his PhD from Harvard University, and Postdoctoral training at Stanford University School of Medicine and NIH. His group studies chromatin activation and epigenetic repression at the systems level, to gain insight into genome architecture in childhood cancers. He is motivated to understand the essential roles of chromatin regulatory complexes in low mutational burden tumors. For studies in the lab, interdisciplinary approaches are developed to ask (1) how aberrant chromatin repression can drive human disease, (2) why chromatin remodeling is under positive selection in certain pediatric tumors, and (3) whether new methods can enable insights into chromatin deregulation. Ben is excited about mentoring next-generation of scientist and for fundamental insights that enable translational advances. Publications

                  Masih KE, Gardner RA, Chou HC, Abdelmaksoud A, Song YK, Mariani L, Gangalapudi V, Gryder BE, Wilson AL, Adebola SO, Stanton BZ, Wang C, Milewski D, Kim YY, Tian M, Cheuk AT, Wen X, Zhang Y, Altan-Bonnet G, Kelly MC, Wei JS, Bulyk ML, Jensen MC, Orentas RJ, Khan J. A stem cell epigenome is associated with primary nonresponse to CD19 CAR T-cells in pediatric acute lymphoblastic leukemia. Blood Adv. 2023 Jan 6;  

                


                  Wang M, Sunkel BD, Ray WC, Stanton BZ. Chromatin structure in cancer. BMC Mol Cell Biol. 2022 Jul 28; 23: 35.

                


                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.

                


                  Popova LV, Nagarajan P, Lovejoy CM, Sunkel BD, Gardner ML, Wang M, Freitas MA, Stanton BZ, Parthun MR. Epigenetic regulation of nuclear lamina-associated heterochromatin by HAT1 and the acetylation of newly synthesized histones. Nucleic Acids Res. 2021 Dec 2; 49: 12136-12151.

                


                  Laubscher D, Gryder BE, Sunkel BD, Andresson T, Wachtel M, Das S, Roschitzki B, Wolski W, Wu XS, Chou HC, Song YK, Wang C, Wei JS, Wang M, Wen X, Ngo QA, Marques JG, Vakoc CR, Schäfer BW, Stanton BZ, Khan J. BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma. Nat Commun. 2021 Nov 26; 12: 6924.

                


                  Wang L, Hensch NR, Bondra K, Sreenivas P, Zhao XR, Chen J, Moreno Campos R, Baxi K, Vaseva AV, Sunkel BD, Gryder BE, Pomella S, Stanton BZ, Zheng S, Chen EY, Rota R, Khan J, Houghton PJ, Ignatius MS. SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation. Cancer Res. 2021 Nov 1; 81: 5451-5463.

                


                  Sunkel BD, Stanton BZ. Pioneer factors in development and cancer. iScience. 2021 Oct 22; 24: 103132.

                


                  Sunkel BD, Wang M, LaHaye S, Kelly BJ, Fitch JR, Barr FG, White P, Stanton BZ. Evidence of pioneer factor activity of an oncogenic fusion transcription factor. iScience. 2021 Aug 20; 24: 102867.

                


                  Tallan A, Stanton BZ. Inducible Protein Degradation to Understand Genome Architecture. Biochemistry. 2021 Aug 10; 60: 2387-2396.

                


                  Boone MA, Taslim C, Crow JC, Selich-Anderson J, Byrum AK, Showpnil IA, Sunkel BD, Wang M, Stanton BZ, Theisen ER, Lessnick SL. The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma. Oncogene. 2021 Jul; 40: 4759-4769.

                


                  Weber CM, Hafner A, Kirkland JG, Braun SMG, Stanton BZ, Boettiger AN, Crabtree GR. mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution. Nat Struct Mol Biol. 2021 Jun; 28: 501-511.

                


                  Pomella S, Sreenivas P, Gryder BE, Wang L, Milewski D, Cassandri M, Baxi K, Hensch NR, Carcarino E, Song Y, Chou HC, Yohe ME, Stanton BZ, Amadio B, Caruana I, De Stefanis C, De Vito R, Locatelli F, Chen Y, Chen EY, Houghton P, Khan J, Rota R, Ignatius MS. Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma. Nat Commun. 2021 Jan 8; 12: 192.

                


                  Gryder BE, Wachtel M, Chang K, El Demerdash O, Aboreden NG, Mohammed W, Ewert W, Pomella S, Rota R, Wei JS, Song Y, Stanton BZ, Schäfer B, Vakoc CR, Khan J. Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage. iScience. 2020 May 22; 23: 101103.

                


                  Gryder BE, Khan J, Stanton BZ. Measurement of differential chromatin interactions with absolute quantification of architecture (AQuA-HiChIP). Nat Protoc. 2020 Mar; 15: 1209-1236.

                


                  Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, Vakoc CR, Shern JF, Stanton BZ, Khan J. Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma. Nat Genet. 2019 Dec; 51: 1714-1722.

                


                  Lin GL, Wilson KM, Ceribelli M, Stanton BZ, Woo PJ, Kreimer S, Qin EY, Zhang X, Lennon J, Nagaraja S, Morris PJ, Quezada M, Gillespie SM, Duveau DY, Michalowski AM, Shinn P, Guha R, Ferrer M, Klumpp-Thomas C, Michael S, McKnight C, Minhas P, Itkin Z, Raabe EH, Chen L, Ghanem R, Geraghty AC, Ni L, Andreasson KI, Vitanza NA, Warren KE, Thomas CJ, Monje M. Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening. Sci Transl Med. 2019 Nov 20; 11: 

                


                  Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O, Frye SV. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Oct 17; 26: 1365-1379.e22.

                


                  Gryder BE, Wu L, Woldemichael GM, Pomella S, Quinn TR, Park PMC, Cleveland A, Stanton BZ, Song Y, Rota R, Wiest O, Yohe ME, Shern JF, Qi J, Khan J. Chemical genomics reveals histone deacetylases are required for core regulatory transcription. Nat Commun. 2019 Jul 8; 10: 3004.

                


                  Lai B, Tang Q, Jin W, Hu G, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. Trac-looping measures genome structure and chromatin accessibility. Nat Methods. 2018 Sep; 15: 741-747.

                


                  Stanton BZ, Chory EJ, Crabtree GR. Chemically induced proximity in biology and medicine. Science. 2018 Mar 9; 359: 

                


                  Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nat Struct Mol Biol. 2018 Jan; 25: 61-72.

View More Publications

Research

Lab(s)

Center for Childhood Cancer

Ben Stanton, PhD, is a principal investigator in the Center for Childhood Cancer at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, and assistant professor at The Ohio State University College of Medicine. Ben received his PhD from Harvard University, and Postdoctoral training at Stanford University School of Medicine and NIH. His group studies chromatin activation and epigenetic repression at the systems level, to gain insight into genome architecture in childhood cancers. He is motivated to understand the essential roles of chromatin regulatory complexes in low mutational burden tumors. For studies in the lab, interdisciplinary approaches are developed to ask (1) how aberrant chromatin repression can drive human disease, (2) why chromatin remodeling is under positive selection in certain pediatric tumors, and (3) whether new methods can enable insights into chromatin deregulation. Ben is excited about mentoring next-generation of scientist and for fundamental insights that enable translational advances. Publications

                  Masih KE, Gardner RA, Chou HC, Abdelmaksoud A, Song YK, Mariani L, Gangalapudi V, Gryder BE, Wilson AL, Adebola SO, Stanton BZ, Wang C, Milewski D, Kim YY, Tian M, Cheuk AT, Wen X, Zhang Y, Altan-Bonnet G, Kelly MC, Wei JS, Bulyk ML, Jensen MC, Orentas RJ, Khan J. A stem cell epigenome is associated with primary nonresponse to CD19 CAR T-cells in pediatric acute lymphoblastic leukemia. Blood Adv. 2023 Jan 6;  

                


                  Wang M, Sunkel BD, Ray WC, Stanton BZ. Chromatin structure in cancer. BMC Mol Cell Biol. 2022 Jul 28; 23: 35.

                


                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.

                


                  Popova LV, Nagarajan P, Lovejoy CM, Sunkel BD, Gardner ML, Wang M, Freitas MA, Stanton BZ, Parthun MR. Epigenetic regulation of nuclear lamina-associated heterochromatin by HAT1 and the acetylation of newly synthesized histones. Nucleic Acids Res. 2021 Dec 2; 49: 12136-12151.

                


                  Laubscher D, Gryder BE, Sunkel BD, Andresson T, Wachtel M, Das S, Roschitzki B, Wolski W, Wu XS, Chou HC, Song YK, Wang C, Wei JS, Wang M, Wen X, Ngo QA, Marques JG, Vakoc CR, Schäfer BW, Stanton BZ, Khan J. BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma. Nat Commun. 2021 Nov 26; 12: 6924.

                


                  Wang L, Hensch NR, Bondra K, Sreenivas P, Zhao XR, Chen J, Moreno Campos R, Baxi K, Vaseva AV, Sunkel BD, Gryder BE, Pomella S, Stanton BZ, Zheng S, Chen EY, Rota R, Khan J, Houghton PJ, Ignatius MS. SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation. Cancer Res. 2021 Nov 1; 81: 5451-5463.

                


                  Sunkel BD, Stanton BZ. Pioneer factors in development and cancer. iScience. 2021 Oct 22; 24: 103132.

                


                  Sunkel BD, Wang M, LaHaye S, Kelly BJ, Fitch JR, Barr FG, White P, Stanton BZ. Evidence of pioneer factor activity of an oncogenic fusion transcription factor. iScience. 2021 Aug 20; 24: 102867.

                


                  Tallan A, Stanton BZ. Inducible Protein Degradation to Understand Genome Architecture. Biochemistry. 2021 Aug 10; 60: 2387-2396.

                


                  Boone MA, Taslim C, Crow JC, Selich-Anderson J, Byrum AK, Showpnil IA, Sunkel BD, Wang M, Stanton BZ, Theisen ER, Lessnick SL. The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma. Oncogene. 2021 Jul; 40: 4759-4769.

                


                  Weber CM, Hafner A, Kirkland JG, Braun SMG, Stanton BZ, Boettiger AN, Crabtree GR. mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution. Nat Struct Mol Biol. 2021 Jun; 28: 501-511.

                


                  Pomella S, Sreenivas P, Gryder BE, Wang L, Milewski D, Cassandri M, Baxi K, Hensch NR, Carcarino E, Song Y, Chou HC, Yohe ME, Stanton BZ, Amadio B, Caruana I, De Stefanis C, De Vito R, Locatelli F, Chen Y, Chen EY, Houghton P, Khan J, Rota R, Ignatius MS. Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma. Nat Commun. 2021 Jan 8; 12: 192.

                


                  Gryder BE, Wachtel M, Chang K, El Demerdash O, Aboreden NG, Mohammed W, Ewert W, Pomella S, Rota R, Wei JS, Song Y, Stanton BZ, Schäfer B, Vakoc CR, Khan J. Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage. iScience. 2020 May 22; 23: 101103.

                


                  Gryder BE, Khan J, Stanton BZ. Measurement of differential chromatin interactions with absolute quantification of architecture (AQuA-HiChIP). Nat Protoc. 2020 Mar; 15: 1209-1236.

                


                  Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, Vakoc CR, Shern JF, Stanton BZ, Khan J. Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma. Nat Genet. 2019 Dec; 51: 1714-1722.

                


                  Lin GL, Wilson KM, Ceribelli M, Stanton BZ, Woo PJ, Kreimer S, Qin EY, Zhang X, Lennon J, Nagaraja S, Morris PJ, Quezada M, Gillespie SM, Duveau DY, Michalowski AM, Shinn P, Guha R, Ferrer M, Klumpp-Thomas C, Michael S, McKnight C, Minhas P, Itkin Z, Raabe EH, Chen L, Ghanem R, Geraghty AC, Ni L, Andreasson KI, Vitanza NA, Warren KE, Thomas CJ, Monje M. Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening. Sci Transl Med. 2019 Nov 20; 11: 

                


                  Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O, Frye SV. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Oct 17; 26: 1365-1379.e22.

                


                  Gryder BE, Wu L, Woldemichael GM, Pomella S, Quinn TR, Park PMC, Cleveland A, Stanton BZ, Song Y, Rota R, Wiest O, Yohe ME, Shern JF, Qi J, Khan J. Chemical genomics reveals histone deacetylases are required for core regulatory transcription. Nat Commun. 2019 Jul 8; 10: 3004.

                


                  Lai B, Tang Q, Jin W, Hu G, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. Trac-looping measures genome structure and chromatin accessibility. Nat Methods. 2018 Sep; 15: 741-747.

                


                  Stanton BZ, Chory EJ, Crabtree GR. Chemically induced proximity in biology and medicine. Science. 2018 Mar 9; 359: 

                


                  Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nat Struct Mol Biol. 2018 Jan; 25: 61-72.

View More Publications

Lab(s)

Center for Childhood Cancer

Ben Stanton, PhD, is a principal investigator in the Center for Childhood Cancer at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, and assistant professor at The Ohio State University College of Medicine. Ben received his PhD from Harvard University, and Postdoctoral training at Stanford University School of Medicine and NIH. His group studies chromatin activation and epigenetic repression at the systems level, to gain insight into genome architecture in childhood cancers. He is motivated to understand the essential roles of chromatin regulatory complexes in low mutational burden tumors. For studies in the lab, interdisciplinary approaches are developed to ask (1) how aberrant chromatin repression can drive human disease, (2) why chromatin remodeling is under positive selection in certain pediatric tumors, and (3) whether new methods can enable insights into chromatin deregulation. Ben is excited about mentoring next-generation of scientist and for fundamental insights that enable translational advances. Publications

                  Masih KE, Gardner RA, Chou HC, Abdelmaksoud A, Song YK, Mariani L, Gangalapudi V, Gryder BE, Wilson AL, Adebola SO, Stanton BZ, Wang C, Milewski D, Kim YY, Tian M, Cheuk AT, Wen X, Zhang Y, Altan-Bonnet G, Kelly MC, Wei JS, Bulyk ML, Jensen MC, Orentas RJ, Khan J. A stem cell epigenome is associated with primary nonresponse to CD19 CAR T-cells in pediatric acute lymphoblastic leukemia. Blood Adv. 2023 Jan 6;  

                


                  Wang M, Sunkel BD, Ray WC, Stanton BZ. Chromatin structure in cancer. BMC Mol Cell Biol. 2022 Jul 28; 23: 35.

                


                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.

                


                  Popova LV, Nagarajan P, Lovejoy CM, Sunkel BD, Gardner ML, Wang M, Freitas MA, Stanton BZ, Parthun MR. Epigenetic regulation of nuclear lamina-associated heterochromatin by HAT1 and the acetylation of newly synthesized histones. Nucleic Acids Res. 2021 Dec 2; 49: 12136-12151.

                


                  Laubscher D, Gryder BE, Sunkel BD, Andresson T, Wachtel M, Das S, Roschitzki B, Wolski W, Wu XS, Chou HC, Song YK, Wang C, Wei JS, Wang M, Wen X, Ngo QA, Marques JG, Vakoc CR, Schäfer BW, Stanton BZ, Khan J. BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma. Nat Commun. 2021 Nov 26; 12: 6924.

                


                  Wang L, Hensch NR, Bondra K, Sreenivas P, Zhao XR, Chen J, Moreno Campos R, Baxi K, Vaseva AV, Sunkel BD, Gryder BE, Pomella S, Stanton BZ, Zheng S, Chen EY, Rota R, Khan J, Houghton PJ, Ignatius MS. SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation. Cancer Res. 2021 Nov 1; 81: 5451-5463.

                


                  Sunkel BD, Stanton BZ. Pioneer factors in development and cancer. iScience. 2021 Oct 22; 24: 103132.

                


                  Sunkel BD, Wang M, LaHaye S, Kelly BJ, Fitch JR, Barr FG, White P, Stanton BZ. Evidence of pioneer factor activity of an oncogenic fusion transcription factor. iScience. 2021 Aug 20; 24: 102867.

                


                  Tallan A, Stanton BZ. Inducible Protein Degradation to Understand Genome Architecture. Biochemistry. 2021 Aug 10; 60: 2387-2396.

                


                  Boone MA, Taslim C, Crow JC, Selich-Anderson J, Byrum AK, Showpnil IA, Sunkel BD, Wang M, Stanton BZ, Theisen ER, Lessnick SL. The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma. Oncogene. 2021 Jul; 40: 4759-4769.

                


                  Weber CM, Hafner A, Kirkland JG, Braun SMG, Stanton BZ, Boettiger AN, Crabtree GR. mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution. Nat Struct Mol Biol. 2021 Jun; 28: 501-511.

                


                  Pomella S, Sreenivas P, Gryder BE, Wang L, Milewski D, Cassandri M, Baxi K, Hensch NR, Carcarino E, Song Y, Chou HC, Yohe ME, Stanton BZ, Amadio B, Caruana I, De Stefanis C, De Vito R, Locatelli F, Chen Y, Chen EY, Houghton P, Khan J, Rota R, Ignatius MS. Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma. Nat Commun. 2021 Jan 8; 12: 192.

                


                  Gryder BE, Wachtel M, Chang K, El Demerdash O, Aboreden NG, Mohammed W, Ewert W, Pomella S, Rota R, Wei JS, Song Y, Stanton BZ, Schäfer B, Vakoc CR, Khan J. Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage. iScience. 2020 May 22; 23: 101103.

                


                  Gryder BE, Khan J, Stanton BZ. Measurement of differential chromatin interactions with absolute quantification of architecture (AQuA-HiChIP). Nat Protoc. 2020 Mar; 15: 1209-1236.

                


                  Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, Vakoc CR, Shern JF, Stanton BZ, Khan J. Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma. Nat Genet. 2019 Dec; 51: 1714-1722.

                


                  Lin GL, Wilson KM, Ceribelli M, Stanton BZ, Woo PJ, Kreimer S, Qin EY, Zhang X, Lennon J, Nagaraja S, Morris PJ, Quezada M, Gillespie SM, Duveau DY, Michalowski AM, Shinn P, Guha R, Ferrer M, Klumpp-Thomas C, Michael S, McKnight C, Minhas P, Itkin Z, Raabe EH, Chen L, Ghanem R, Geraghty AC, Ni L, Andreasson KI, Vitanza NA, Warren KE, Thomas CJ, Monje M. Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening. Sci Transl Med. 2019 Nov 20; 11: 

                


                  Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O, Frye SV. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Oct 17; 26: 1365-1379.e22.

                


                  Gryder BE, Wu L, Woldemichael GM, Pomella S, Quinn TR, Park PMC, Cleveland A, Stanton BZ, Song Y, Rota R, Wiest O, Yohe ME, Shern JF, Qi J, Khan J. Chemical genomics reveals histone deacetylases are required for core regulatory transcription. Nat Commun. 2019 Jul 8; 10: 3004.

                


                  Lai B, Tang Q, Jin W, Hu G, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. Trac-looping measures genome structure and chromatin accessibility. Nat Methods. 2018 Sep; 15: 741-747.

                


                  Stanton BZ, Chory EJ, Crabtree GR. Chemically induced proximity in biology and medicine. Science. 2018 Mar 9; 359: 

                


                  Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nat Struct Mol Biol. 2018 Jan; 25: 61-72.

View More Publications

Lab(s)

Center for Childhood Cancer

Ben Stanton, PhD, is a principal investigator in the Center for Childhood Cancer at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, and assistant professor at The Ohio State University College of Medicine. Ben received his PhD from Harvard University, and Postdoctoral training at Stanford University School of Medicine and NIH. His group studies chromatin activation and epigenetic repression at the systems level, to gain insight into genome architecture in childhood cancers. He is motivated to understand the essential roles of chromatin regulatory complexes in low mutational burden tumors. For studies in the lab, interdisciplinary approaches are developed to ask (1) how aberrant chromatin repression can drive human disease, (2) why chromatin remodeling is under positive selection in certain pediatric tumors, and (3) whether new methods can enable insights into chromatin deregulation. Ben is excited about mentoring next-generation of scientist and for fundamental insights that enable translational advances.

Lab(s)

Center for Childhood Cancer

• Center for Childhood Cancer

                  Masih KE, Gardner RA, Chou HC, Abdelmaksoud A, Song YK, Mariani L, Gangalapudi V, Gryder BE, Wilson AL, Adebola SO, Stanton BZ, Wang C, Milewski D, Kim YY, Tian M, Cheuk AT, Wen X, Zhang Y, Altan-Bonnet G, Kelly MC, Wei JS, Bulyk ML, Jensen MC, Orentas RJ, Khan J. A stem cell epigenome is associated with primary nonresponse to CD19 CAR T-cells in pediatric acute lymphoblastic leukemia. Blood Adv. 2023 Jan 6;  
  
  
  
                  Wang M, Sunkel BD, Ray WC, Stanton BZ. Chromatin structure in cancer. BMC Mol Cell Biol. 2022 Jul 28; 23: 35.
  
  
  
                  Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.
  
  
  
                  Popova LV, Nagarajan P, Lovejoy CM, Sunkel BD, Gardner ML, Wang M, Freitas MA, Stanton BZ, Parthun MR. Epigenetic regulation of nuclear lamina-associated heterochromatin by HAT1 and the acetylation of newly synthesized histones. Nucleic Acids Res. 2021 Dec 2; 49: 12136-12151.
  
  
  
                  Laubscher D, Gryder BE, Sunkel BD, Andresson T, Wachtel M, Das S, Roschitzki B, Wolski W, Wu XS, Chou HC, Song YK, Wang C, Wei JS, Wang M, Wen X, Ngo QA, Marques JG, Vakoc CR, Schäfer BW, Stanton BZ, Khan J. BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma. Nat Commun. 2021 Nov 26; 12: 6924.
  
  
  
                  Wang L, Hensch NR, Bondra K, Sreenivas P, Zhao XR, Chen J, Moreno Campos R, Baxi K, Vaseva AV, Sunkel BD, Gryder BE, Pomella S, Stanton BZ, Zheng S, Chen EY, Rota R, Khan J, Houghton PJ, Ignatius MS. SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation. Cancer Res. 2021 Nov 1; 81: 5451-5463.
  
  
  
                  Sunkel BD, Stanton BZ. Pioneer factors in development and cancer. iScience. 2021 Oct 22; 24: 103132.
  
  
  
                  Sunkel BD, Wang M, LaHaye S, Kelly BJ, Fitch JR, Barr FG, White P, Stanton BZ. Evidence of pioneer factor activity of an oncogenic fusion transcription factor. iScience. 2021 Aug 20; 24: 102867.
  
  
  
                  Tallan A, Stanton BZ. Inducible Protein Degradation to Understand Genome Architecture. Biochemistry. 2021 Aug 10; 60: 2387-2396.
  
  
  
                  Boone MA, Taslim C, Crow JC, Selich-Anderson J, Byrum AK, Showpnil IA, Sunkel BD, Wang M, Stanton BZ, Theisen ER, Lessnick SL. The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma. Oncogene. 2021 Jul; 40: 4759-4769.
  
  
  
                  Weber CM, Hafner A, Kirkland JG, Braun SMG, Stanton BZ, Boettiger AN, Crabtree GR. mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution. Nat Struct Mol Biol. 2021 Jun; 28: 501-511.
  
  
  
                  Pomella S, Sreenivas P, Gryder BE, Wang L, Milewski D, Cassandri M, Baxi K, Hensch NR, Carcarino E, Song Y, Chou HC, Yohe ME, Stanton BZ, Amadio B, Caruana I, De Stefanis C, De Vito R, Locatelli F, Chen Y, Chen EY, Houghton P, Khan J, Rota R, Ignatius MS. Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma. Nat Commun. 2021 Jan 8; 12: 192.
  
  
  
                  Gryder BE, Wachtel M, Chang K, El Demerdash O, Aboreden NG, Mohammed W, Ewert W, Pomella S, Rota R, Wei JS, Song Y, Stanton BZ, Schäfer B, Vakoc CR, Khan J. Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage. iScience. 2020 May 22; 23: 101103.
  
  
  
                  Gryder BE, Khan J, Stanton BZ. Measurement of differential chromatin interactions with absolute quantification of architecture (AQuA-HiChIP). Nat Protoc. 2020 Mar; 15: 1209-1236.
  
  
  
                  Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, Vakoc CR, Shern JF, Stanton BZ, Khan J. Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma. Nat Genet. 2019 Dec; 51: 1714-1722.
  
  
  
                  Lin GL, Wilson KM, Ceribelli M, Stanton BZ, Woo PJ, Kreimer S, Qin EY, Zhang X, Lennon J, Nagaraja S, Morris PJ, Quezada M, Gillespie SM, Duveau DY, Michalowski AM, Shinn P, Guha R, Ferrer M, Klumpp-Thomas C, Michael S, McKnight C, Minhas P, Itkin Z, Raabe EH, Chen L, Ghanem R, Geraghty AC, Ni L, Andreasson KI, Vitanza NA, Warren KE, Thomas CJ, Monje M. Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening. Sci Transl Med. 2019 Nov 20; 11: 
  
  
  
                  Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O, Frye SV. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Oct 17; 26: 1365-1379.e22.
  
  
  
                  Gryder BE, Wu L, Woldemichael GM, Pomella S, Quinn TR, Park PMC, Cleveland A, Stanton BZ, Song Y, Rota R, Wiest O, Yohe ME, Shern JF, Qi J, Khan J. Chemical genomics reveals histone deacetylases are required for core regulatory transcription. Nat Commun. 2019 Jul 8; 10: 3004.
  
  
  
                  Lai B, Tang Q, Jin W, Hu G, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. Trac-looping measures genome structure and chromatin accessibility. Nat Methods. 2018 Sep; 15: 741-747.
  
  
  
                  Stanton BZ, Chory EJ, Crabtree GR. Chemically induced proximity in biology and medicine. Science. 2018 Mar 9; 359: 
  
  
  
                  Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nat Struct Mol Biol. 2018 Jan; 25: 61-72.
  
  

View More Publications

• Masih KE, Gardner RA, Chou HC, Abdelmaksoud A, Song YK, Mariani L, Gangalapudi V, Gryder BE, Wilson AL, Adebola SO, Stanton BZ, Wang C, Milewski D, Kim YY, Tian M, Cheuk AT, Wen X, Zhang Y, Altan-Bonnet G, Kelly MC, Wei JS, Bulyk ML, Jensen MC, Orentas RJ, Khan J. A stem cell epigenome is associated with primary nonresponse to CD19 CAR T-cells in pediatric acute lymphoblastic leukemia. Blood Adv. 2023 Jan 6;
• Wang M, Sunkel BD, Ray WC, Stanton BZ. Chromatin structure in cancer. BMC Mol Cell Biol. 2022 Jul 28; 23: 35.
• Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Muñoz-Cabello AM, Lopez-Barneo J, Yang J, Lane AN, Xin G, Stanton BZ, Fan TW, Wang R. Succinate dehydrogenase/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022 Apr 29; 7: eabm8161.
• Popova LV, Nagarajan P, Lovejoy CM, Sunkel BD, Gardner ML, Wang M, Freitas MA, Stanton BZ, Parthun MR. Epigenetic regulation of nuclear lamina-associated heterochromatin by HAT1 and the acetylation of newly synthesized histones. Nucleic Acids Res. 2021 Dec 2; 49: 12136-12151.
• Laubscher D, Gryder BE, Sunkel BD, Andresson T, Wachtel M, Das S, Roschitzki B, Wolski W, Wu XS, Chou HC, Song YK, Wang C, Wei JS, Wang M, Wen X, Ngo QA, Marques JG, Vakoc CR, Schäfer BW, Stanton BZ, Khan J. BAF complexes drive proliferation and block myogenic differentiation in fusion-positive rhabdomyosarcoma. Nat Commun. 2021 Nov 26; 12: 6924.
• Wang L, Hensch NR, Bondra K, Sreenivas P, Zhao XR, Chen J, Moreno Campos R, Baxi K, Vaseva AV, Sunkel BD, Gryder BE, Pomella S, Stanton BZ, Zheng S, Chen EY, Rota R, Khan J, Houghton PJ, Ignatius MS. SNAI2-Mediated Repression of BIM Protects Rhabdomyosarcoma from Ionizing Radiation. Cancer Res. 2021 Nov 1; 81: 5451-5463.
• Sunkel BD, Stanton BZ. Pioneer factors in development and cancer. iScience. 2021 Oct 22; 24: 103132.
• Sunkel BD, Wang M, LaHaye S, Kelly BJ, Fitch JR, Barr FG, White P, Stanton BZ. Evidence of pioneer factor activity of an oncogenic fusion transcription factor. iScience. 2021 Aug 20; 24: 102867.
• Tallan A, Stanton BZ. Inducible Protein Degradation to Understand Genome Architecture. Biochemistry. 2021 Aug 10; 60: 2387-2396.
• Boone MA, Taslim C, Crow JC, Selich-Anderson J, Byrum AK, Showpnil IA, Sunkel BD, Wang M, Stanton BZ, Theisen ER, Lessnick SL. The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma. Oncogene. 2021 Jul; 40: 4759-4769.
• Weber CM, Hafner A, Kirkland JG, Braun SMG, Stanton BZ, Boettiger AN, Crabtree GR. mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution. Nat Struct Mol Biol. 2021 Jun; 28: 501-511.
• Pomella S, Sreenivas P, Gryder BE, Wang L, Milewski D, Cassandri M, Baxi K, Hensch NR, Carcarino E, Song Y, Chou HC, Yohe ME, Stanton BZ, Amadio B, Caruana I, De Stefanis C, De Vito R, Locatelli F, Chen Y, Chen EY, Houghton P, Khan J, Rota R, Ignatius MS. Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma. Nat Commun. 2021 Jan 8; 12: 192.
• Gryder BE, Wachtel M, Chang K, El Demerdash O, Aboreden NG, Mohammed W, Ewert W, Pomella S, Rota R, Wei JS, Song Y, Stanton BZ, Schäfer B, Vakoc CR, Khan J. Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage. iScience. 2020 May 22; 23: 101103.
• Gryder BE, Khan J, Stanton BZ. Measurement of differential chromatin interactions with absolute quantification of architecture (AQuA-HiChIP). Nat Protoc. 2020 Mar; 15: 1209-1236.
• Gryder BE, Pomella S, Sayers C, Wu XS, Song Y, Chiarella AM, Bagchi S, Chou HC, Sinniah RS, Walton A, Wen X, Rota R, Hathaway NA, Zhao K, Chen J, Vakoc CR, Shern JF, Stanton BZ, Khan J. Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma. Nat Genet. 2019 Dec; 51: 1714-1722.
• Lin GL, Wilson KM, Ceribelli M, Stanton BZ, Woo PJ, Kreimer S, Qin EY, Zhang X, Lennon J, Nagaraja S, Morris PJ, Quezada M, Gillespie SM, Duveau DY, Michalowski AM, Shinn P, Guha R, Ferrer M, Klumpp-Thomas C, Michael S, McKnight C, Minhas P, Itkin Z, Raabe EH, Chen L, Ghanem R, Geraghty AC, Ni L, Andreasson KI, Vitanza NA, Warren KE, Thomas CJ, Monje M. Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening. Sci Transl Med. 2019 Nov 20; 11:
• Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O, Frye SV. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 Oct 17; 26: 1365-1379.e22.
• Gryder BE, Wu L, Woldemichael GM, Pomella S, Quinn TR, Park PMC, Cleveland A, Stanton BZ, Song Y, Rota R, Wiest O, Yohe ME, Shern JF, Qi J, Khan J. Chemical genomics reveals histone deacetylases are required for core regulatory transcription. Nat Commun. 2019 Jul 8; 10: 3004.
• Lai B, Tang Q, Jin W, Hu G, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. Trac-looping measures genome structure and chromatin accessibility. Nat Methods. 2018 Sep; 15: 741-747.
• Stanton BZ, Chory EJ, Crabtree GR. Chemically induced proximity in biology and medicine. Science. 2018 Mar 9; 359:
• Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nat Struct Mol Biol. 2018 Jan; 25: 61-72.

Academic and Clinical Areas

Center for Childhood Cancer

Principal Investigator

Primary Department

Center for Childhood Cancer

Academic and Clinical Areas

Center for Childhood Cancer

Principal Investigator

Primary Department

Center for Childhood Cancer

Academic and Clinical Areas

Center for Childhood Cancer

Principal Investigator

Primary Department

Center for Childhood Cancer

Center for Childhood Cancer

Principal Investigator

Primary Department

Center for Childhood Cancer

• Center for Childhood Cancer
• Principal Investigator
• Primary Department
• Center for Childhood Cancer

Awards, Honors & Organizations

St. Baldrick’s Scholar Award, 2019 NIH National Center for Advancing Translational Sciences Director’s Award, 2018

Awards, Honors & Organizations

St. Baldrick’s Scholar Award, 2019 NIH National Center for Advancing Translational Sciences Director’s Award, 2018

Awards, Honors & Organizations

St. Baldrick’s Scholar Award, 2019 NIH National Center for Advancing Translational Sciences Director’s Award, 2018

St. Baldrick’s Scholar Award, 2019 NIH National Center for Advancing Translational Sciences Director’s Award, 2018

• St. Baldrick’s Scholar Award, 2019
• NIH National Center for Advancing Translational Sciences Director’s Award, 2018

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2019

Graduate School

Harvard University

Date Completed: 06/04/2009

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2019

Graduate School

Harvard University

Date Completed: 06/04/2009

Education

Date of Appointment at Nationwide Children’s Hospital: 07/01/2019

Graduate School

Harvard University

Date Completed: 06/04/2009

Date of Appointment at Nationwide Children’s Hospital: 07/01/2019

Graduate School

Harvard University

Date Completed: 06/04/2009

Date of Appointment at Nationwide Children’s Hospital: 07/01/2019

Graduate School

Harvard University

Date Completed: 06/04/2009

Contact Information

Center for Childhood Cancer

Call us at: (301) 613-9390

Email Benjamin Stanton

                    700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Center for Childhood Cancer

Call us at: (301) 613-9390

Email Benjamin Stanton

                    700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Center for Childhood Cancer

Call us at: (301) 613-9390

Email Benjamin Stanton

                    700 Children's DriveColumbus, OH 43205 (map)

Center for Childhood Cancer

Call us at: (301) 613-9390

Email Benjamin Stanton

                    700 Children's DriveColumbus, OH 43205 (map)

Call us at: (301) 613-9390

Email Benjamin Stanton

                    700 Children's DriveColumbus, OH 43205 (map)

Call us at: (301) 613-9390

Email Benjamin Stanton

                    700 Children's DriveColumbus, OH 43205 (map)

• Call us at:
• (301) 613-9390
• Email Benjamin Stanton
• 700 Children’s DriveColumbus, OH 43205 (map)