Contact Information
Call us at: (614) 722-2784
Center for Clinical and Translational Research700 Children’s DriveColumbus, OH 43205 (map)
Learn more about Balamurugan N. Appakalai
Research
Lab(s)
Center for Clinical and Translational Research
Dr. Appakalai’s research has focused on ways to improve the vascular supply to isolated islets after transplantation. He has aimed to improve islet microcirculation by stimulating intra-islet endothelial cells and studying the crosstalk between endothelial cells and beta cells. Dr. Appakalai has successfully utilized stem cell approaches to reprogram ductal cells to beta cells. Publications
Graham ML, Ramachandran S, Singh A, Moore MEG, Flanagan EB, Azimzadeh A, Burlak C, Mueller KR, Martins K, Anazawa T, Appakalai BN, Bansal-Pakala P, Murtaugh MP, O'Brien TD, Papas KK, Spizzo T, Schuurman HJ, Hancock WW, Hering BJ. Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques. Am J Transplant. 2022 Mar; 22: 745-760.
View More Publications
Biography
Balamurugan N. Appakalai, PhD, is a principal investigator in the Center for Clinical and Translational Research and a member of the pancreatic islet cell transplantation program at Nationwide Children’s. Dr. Appakalai has extensive experience in processing human pancreases for clinical islet auto-transplantation and allo-transplantation for the treatment of brittle diabetes. He has been working in this field for over 25 years, focusing on advancing pancreatic islet cell isolation and transplantation to achieve long-term insulin-free status in patients. He has been actively involved in the grant review process for NIH, ADA, JDRF and other international funding agencies and has presented nationally and internationally on his research on islet cell transplantation.
Academic and Clinical Areas
Center for Clinical and Translational Research
Principal Investigator
Primary Department
Center for Clinical and Translational Research
Education
Doctorate
Christian Medical College, Vellore
Date Completed: 12/31/1998
Master’s
University of Madras
Date Completed: 12/31/1993
Contact Information
Center for Clinical and Translational Research
Call us at: (614) 722-2784
700 Children's DriveColumbus, OH 43205 (map)
Contact Information
Call us at: (614) 722-2784
Center for Clinical and Translational Research700 Children’s DriveColumbus, OH 43205 (map)
Learn more about Balamurugan N. Appakalai
Research
Lab(s)
Center for Clinical and Translational Research
Dr. Appakalai’s research has focused on ways to improve the vascular supply to isolated islets after transplantation. He has aimed to improve islet microcirculation by stimulating intra-islet endothelial cells and studying the crosstalk between endothelial cells and beta cells. Dr. Appakalai has successfully utilized stem cell approaches to reprogram ductal cells to beta cells. Publications
Graham ML, Ramachandran S, Singh A, Moore MEG, Flanagan EB, Azimzadeh A, Burlak C, Mueller KR, Martins K, Anazawa T, Appakalai BN, Bansal-Pakala P, Murtaugh MP, O'Brien TD, Papas KK, Spizzo T, Schuurman HJ, Hancock WW, Hering BJ. Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques. Am J Transplant. 2022 Mar; 22: 745-760.
View More Publications
Biography
Balamurugan N. Appakalai, PhD, is a principal investigator in the Center for Clinical and Translational Research and a member of the pancreatic islet cell transplantation program at Nationwide Children’s. Dr. Appakalai has extensive experience in processing human pancreases for clinical islet auto-transplantation and allo-transplantation for the treatment of brittle diabetes. He has been working in this field for over 25 years, focusing on advancing pancreatic islet cell isolation and transplantation to achieve long-term insulin-free status in patients. He has been actively involved in the grant review process for NIH, ADA, JDRF and other international funding agencies and has presented nationally and internationally on his research on islet cell transplantation.
Academic and Clinical Areas
Center for Clinical and Translational Research
Principal Investigator
Primary Department
Center for Clinical and Translational Research
Education
Doctorate
Christian Medical College, Vellore
Date Completed: 12/31/1998
Master’s
University of Madras
Date Completed: 12/31/1993
Contact Information
Center for Clinical and Translational Research
Call us at: (614) 722-2784
700 Children's DriveColumbus, OH 43205 (map)
Contact Information
Call us at: (614) 722-2784
Center for Clinical and Translational Research700 Children’s DriveColumbus, OH 43205 (map)
Learn more about Balamurugan N. Appakalai
Contact Information
- Call us at:
- (614) 722-2784
- Center for Clinical and Translational Research700 Children’s DriveColumbus, OH 43205 (map)
Learn more about Balamurugan N. Appakalai
Research
Lab(s)
Center for Clinical and Translational Research
Dr. Appakalai’s research has focused on ways to improve the vascular supply to isolated islets after transplantation. He has aimed to improve islet microcirculation by stimulating intra-islet endothelial cells and studying the crosstalk between endothelial cells and beta cells. Dr. Appakalai has successfully utilized stem cell approaches to reprogram ductal cells to beta cells. Publications
Graham ML, Ramachandran S, Singh A, Moore MEG, Flanagan EB, Azimzadeh A, Burlak C, Mueller KR, Martins K, Anazawa T, Appakalai BN, Bansal-Pakala P, Murtaugh MP, O'Brien TD, Papas KK, Spizzo T, Schuurman HJ, Hancock WW, Hering BJ. Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques. Am J Transplant. 2022 Mar; 22: 745-760.
View More Publications
Research
Lab(s)
Center for Clinical and Translational Research
Dr. Appakalai’s research has focused on ways to improve the vascular supply to isolated islets after transplantation. He has aimed to improve islet microcirculation by stimulating intra-islet endothelial cells and studying the crosstalk between endothelial cells and beta cells. Dr. Appakalai has successfully utilized stem cell approaches to reprogram ductal cells to beta cells. Publications
Graham ML, Ramachandran S, Singh A, Moore MEG, Flanagan EB, Azimzadeh A, Burlak C, Mueller KR, Martins K, Anazawa T, Appakalai BN, Bansal-Pakala P, Murtaugh MP, O'Brien TD, Papas KK, Spizzo T, Schuurman HJ, Hancock WW, Hering BJ. Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques. Am J Transplant. 2022 Mar; 22: 745-760.
View More Publications
Research
Lab(s)
Center for Clinical and Translational Research
Dr. Appakalai’s research has focused on ways to improve the vascular supply to isolated islets after transplantation. He has aimed to improve islet microcirculation by stimulating intra-islet endothelial cells and studying the crosstalk between endothelial cells and beta cells. Dr. Appakalai has successfully utilized stem cell approaches to reprogram ductal cells to beta cells. Publications
Graham ML, Ramachandran S, Singh A, Moore MEG, Flanagan EB, Azimzadeh A, Burlak C, Mueller KR, Martins K, Anazawa T, Appakalai BN, Bansal-Pakala P, Murtaugh MP, O'Brien TD, Papas KK, Spizzo T, Schuurman HJ, Hancock WW, Hering BJ. Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques. Am J Transplant. 2022 Mar; 22: 745-760.
View More Publications
Lab(s)
Center for Clinical and Translational Research
Dr. Appakalai’s research has focused on ways to improve the vascular supply to isolated islets after transplantation. He has aimed to improve islet microcirculation by stimulating intra-islet endothelial cells and studying the crosstalk between endothelial cells and beta cells. Dr. Appakalai has successfully utilized stem cell approaches to reprogram ductal cells to beta cells. Publications
Graham ML, Ramachandran S, Singh A, Moore MEG, Flanagan EB, Azimzadeh A, Burlak C, Mueller KR, Martins K, Anazawa T, Appakalai BN, Bansal-Pakala P, Murtaugh MP, O'Brien TD, Papas KK, Spizzo T, Schuurman HJ, Hancock WW, Hering BJ. Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques. Am J Transplant. 2022 Mar; 22: 745-760.
View More Publications
Lab(s)
Center for Clinical and Translational Research
Dr. Appakalai’s research has focused on ways to improve the vascular supply to isolated islets after transplantation. He has aimed to improve islet microcirculation by stimulating intra-islet endothelial cells and studying the crosstalk between endothelial cells and beta cells. Dr. Appakalai has successfully utilized stem cell approaches to reprogram ductal cells to beta cells.
Lab(s)
Center for Clinical and Translational Research
Center for Clinical and Translational Research
Graham ML, Ramachandran S, Singh A, Moore MEG, Flanagan EB, Azimzadeh A, Burlak C, Mueller KR, Martins K, Anazawa T, Appakalai BN, Bansal-Pakala P, Murtaugh MP, O'Brien TD, Papas KK, Spizzo T, Schuurman HJ, Hancock WW, Hering BJ. Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques. Am J Transplant. 2022 Mar; 22: 745-760.
View More Publications
- Graham ML, Ramachandran S, Singh A, Moore MEG, Flanagan EB, Azimzadeh A, Burlak C, Mueller KR, Martins K, Anazawa T, Appakalai BN, Bansal-Pakala P, Murtaugh MP, O’Brien TD, Papas KK, Spizzo T, Schuurman HJ, Hancock WW, Hering BJ. Clinically available immunosuppression averts rejection but not systemic inflammation after porcine islet xenotransplant in cynomolgus macaques. Am J Transplant. 2022 Mar; 22: 745-760.
Biography
Balamurugan N. Appakalai, PhD, is a principal investigator in the Center for Clinical and Translational Research and a member of the pancreatic islet cell transplantation program at Nationwide Children’s. Dr. Appakalai has extensive experience in processing human pancreases for clinical islet auto-transplantation and allo-transplantation for the treatment of brittle diabetes. He has been working in this field for over 25 years, focusing on advancing pancreatic islet cell isolation and transplantation to achieve long-term insulin-free status in patients. He has been actively involved in the grant review process for NIH, ADA, JDRF and other international funding agencies and has presented nationally and internationally on his research on islet cell transplantation.
Biography
Balamurugan N. Appakalai, PhD, is a principal investigator in the Center for Clinical and Translational Research and a member of the pancreatic islet cell transplantation program at Nationwide Children’s. Dr. Appakalai has extensive experience in processing human pancreases for clinical islet auto-transplantation and allo-transplantation for the treatment of brittle diabetes. He has been working in this field for over 25 years, focusing on advancing pancreatic islet cell isolation and transplantation to achieve long-term insulin-free status in patients. He has been actively involved in the grant review process for NIH, ADA, JDRF and other international funding agencies and has presented nationally and internationally on his research on islet cell transplantation.
Biography
Balamurugan N. Appakalai, PhD, is a principal investigator in the Center for Clinical and Translational Research and a member of the pancreatic islet cell transplantation program at Nationwide Children’s. Dr. Appakalai has extensive experience in processing human pancreases for clinical islet auto-transplantation and allo-transplantation for the treatment of brittle diabetes. He has been working in this field for over 25 years, focusing on advancing pancreatic islet cell isolation and transplantation to achieve long-term insulin-free status in patients. He has been actively involved in the grant review process for NIH, ADA, JDRF and other international funding agencies and has presented nationally and internationally on his research on islet cell transplantation.
Balamurugan N. Appakalai, PhD, is a principal investigator in the Center for Clinical and Translational Research and a member of the pancreatic islet cell transplantation program at Nationwide Children’s. Dr. Appakalai has extensive experience in processing human pancreases for clinical islet auto-transplantation and allo-transplantation for the treatment of brittle diabetes. He has been working in this field for over 25 years, focusing on advancing pancreatic islet cell isolation and transplantation to achieve long-term insulin-free status in patients. He has been actively involved in the grant review process for NIH, ADA, JDRF and other international funding agencies and has presented nationally and internationally on his research on islet cell transplantation.
Balamurugan N. Appakalai, PhD, is a principal investigator in the Center for Clinical and Translational Research and a member of the pancreatic islet cell transplantation program at Nationwide Children’s.
Dr. Appakalai has extensive experience in processing human pancreases for clinical islet auto-transplantation and allo-transplantation for the treatment of brittle diabetes. He has been working in this field for over 25 years, focusing on advancing pancreatic islet cell isolation and transplantation to achieve long-term insulin-free status in patients.
He has been actively involved in the grant review process for NIH, ADA, JDRF and other international funding agencies and has presented nationally and internationally on his research on islet cell transplantation.
Academic and Clinical Areas
Center for Clinical and Translational Research
Principal Investigator
Primary Department
Center for Clinical and Translational Research
Academic and Clinical Areas
Center for Clinical and Translational Research
Principal Investigator
Primary Department
Center for Clinical and Translational Research
Academic and Clinical Areas
Center for Clinical and Translational Research
Principal Investigator
Primary Department
Center for Clinical and Translational Research
Center for Clinical and Translational Research
Principal Investigator
Primary Department
Center for Clinical and Translational Research
- Center for Clinical and Translational Research
- Principal Investigator
- Primary Department
- Center for Clinical and Translational Research
Education
Doctorate
Christian Medical College, Vellore
Date Completed: 12/31/1998
Master’s
University of Madras
Date Completed: 12/31/1993
Education
Doctorate
Christian Medical College, Vellore
Date Completed: 12/31/1998
Master’s
University of Madras
Date Completed: 12/31/1993
Education
Doctorate
Christian Medical College, Vellore
Date Completed: 12/31/1998
Master’s
University of Madras
Date Completed: 12/31/1993
Doctorate
Christian Medical College, Vellore
Date Completed: 12/31/1998
Master’s
University of Madras
Date Completed: 12/31/1993
Doctorate
Christian Medical College, Vellore
Date Completed: 12/31/1998
Master’s
University of Madras
Date Completed: 12/31/1993
Contact Information
Center for Clinical and Translational Research
Call us at: (614) 722-2784
700 Children's DriveColumbus, OH 43205 (map)
Contact Information
Center for Clinical and Translational Research
Call us at: (614) 722-2784
700 Children's DriveColumbus, OH 43205 (map)
Contact Information
Center for Clinical and Translational Research
Call us at: (614) 722-2784
700 Children's DriveColumbus, OH 43205 (map)
Center for Clinical and Translational Research
Call us at: (614) 722-2784
700 Children's DriveColumbus, OH 43205 (map)
Call us at: (614) 722-2784
700 Children's DriveColumbus, OH 43205 (map)
Call us at: (614) 722-2784
700 Children's DriveColumbus, OH 43205 (map)
- Call us at:
- (614) 722-2784
- 700 Children’s DriveColumbus, OH 43205 (map)
