Contact Information

Call us at: (614) 355-2879

Email Ashley R. Jackson, PhD

Kidney and Urinary Tract Center700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Ashley R. Jackson

Biography

Ashley R. Jackson, PhD, is a Principal Investigator in the Center for Clinical and Translational Research and member of the Division of Pediatric Nephrology and Hypertension at Nationwide Children’s Hospital, and Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Jackson’s research program focuses on understanding the role and response of the renal urothelium during urinary tract obstruction. Urinary Tract Obstruction (UTO) is a leading cause of pediatric chronic kidney disease (CKD) and end stage renal disease. Apart from surgery to relieve UTO, no specific interventions can prevent or limit obstructive nephropathy (UTO induced kidney injury and dysfunction). Dr. Jackson discovered that renal urothelial remodeling is a unifying and protective feature of both congenital and acquired forms of urinary tract obstruction. Her research supports the hypothesis that the renal urothelium represents the front line of defense to urinary tract obstruction, and a novel target for the development of therapies to mitigate obstructive kidney disease.   

Academic and Clinical Areas

Nephrology and Urology Research Affinity Group

Faculty

Primary Department

Kidney and Urinary Tract Center

Research

Dr. Jackson’s lab uses powerful pre-clinical models, cutting-edge organoid models, and transcriptomics to investigate the renal urothelial stem cell and its governing pathways during development and repair. These efforts form the foundation for the development of novel therapies that may mitigate obstructive kidney disease. Publications

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE. Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. J Clin Invest. 2019 Dec 2; 129: 5374-5380.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Gupta S, Jackson AR, DaJusta DG, McLeod DJ, Alpert SA, Jayanthi VR, McHugh K, Schwaderer AR, Becknell B, Ching CB. Urinary antimicrobial peptides: Potential novel biomarkers of obstructive uropathy. J Pediatr Urol. 2018 Jun; 14: 238.e1-238.e6.

                


                  Carpenter AR, McHugh KM. Role of renal urothelium in the development and progression of kidney disease. Pediatr Nephrol. 2017 Apr; 32: 557-564.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 09/01/2020

Fellowship

Nationwide Children’s Hospital

Date Completed: 08/31/2020

Graduate School

The Ohio State University

Date Completed: 05/31/2016

Contact Information

Kidney and Urinary Tract Center

Call us at: (614) 355-2879

Email Ashley R Jackson

                    700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 355-2879

Email Ashley R. Jackson, PhD

Kidney and Urinary Tract Center700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Ashley R. Jackson

Biography

Ashley R. Jackson, PhD, is a Principal Investigator in the Center for Clinical and Translational Research and member of the Division of Pediatric Nephrology and Hypertension at Nationwide Children’s Hospital, and Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Jackson’s research program focuses on understanding the role and response of the renal urothelium during urinary tract obstruction. Urinary Tract Obstruction (UTO) is a leading cause of pediatric chronic kidney disease (CKD) and end stage renal disease. Apart from surgery to relieve UTO, no specific interventions can prevent or limit obstructive nephropathy (UTO induced kidney injury and dysfunction). Dr. Jackson discovered that renal urothelial remodeling is a unifying and protective feature of both congenital and acquired forms of urinary tract obstruction. Her research supports the hypothesis that the renal urothelium represents the front line of defense to urinary tract obstruction, and a novel target for the development of therapies to mitigate obstructive kidney disease.   

Academic and Clinical Areas

Nephrology and Urology Research Affinity Group

Faculty

Primary Department

Kidney and Urinary Tract Center

Research

Dr. Jackson’s lab uses powerful pre-clinical models, cutting-edge organoid models, and transcriptomics to investigate the renal urothelial stem cell and its governing pathways during development and repair. These efforts form the foundation for the development of novel therapies that may mitigate obstructive kidney disease. Publications

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE. Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. J Clin Invest. 2019 Dec 2; 129: 5374-5380.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Gupta S, Jackson AR, DaJusta DG, McLeod DJ, Alpert SA, Jayanthi VR, McHugh K, Schwaderer AR, Becknell B, Ching CB. Urinary antimicrobial peptides: Potential novel biomarkers of obstructive uropathy. J Pediatr Urol. 2018 Jun; 14: 238.e1-238.e6.

                


                  Carpenter AR, McHugh KM. Role of renal urothelium in the development and progression of kidney disease. Pediatr Nephrol. 2017 Apr; 32: 557-564.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

Education

Date of Appointment at Nationwide Children’s Hospital: 09/01/2020

Fellowship

Nationwide Children’s Hospital

Date Completed: 08/31/2020

Graduate School

The Ohio State University

Date Completed: 05/31/2016

Contact Information

Kidney and Urinary Tract Center

Call us at: (614) 355-2879

Email Ashley R Jackson

                    700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Call us at: (614) 355-2879

Email Ashley R. Jackson, PhD

Kidney and Urinary Tract Center700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Ashley R. Jackson

Contact Information

  • Call us at:
  • (614) 355-2879
  • Email Ashley R. Jackson, PhD
  • Kidney and Urinary Tract Center700 Children’s DriveColumbus, OH 43205 (map)

Learn more about Ashley R. Jackson

Biography

Ashley R. Jackson, PhD, is a Principal Investigator in the Center for Clinical and Translational Research and member of the Division of Pediatric Nephrology and Hypertension at Nationwide Children’s Hospital, and Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Jackson’s research program focuses on understanding the role and response of the renal urothelium during urinary tract obstruction. Urinary Tract Obstruction (UTO) is a leading cause of pediatric chronic kidney disease (CKD) and end stage renal disease. Apart from surgery to relieve UTO, no specific interventions can prevent or limit obstructive nephropathy (UTO induced kidney injury and dysfunction). Dr. Jackson discovered that renal urothelial remodeling is a unifying and protective feature of both congenital and acquired forms of urinary tract obstruction. Her research supports the hypothesis that the renal urothelium represents the front line of defense to urinary tract obstruction, and a novel target for the development of therapies to mitigate obstructive kidney disease.   

Biography

Ashley R. Jackson, PhD, is a Principal Investigator in the Center for Clinical and Translational Research and member of the Division of Pediatric Nephrology and Hypertension at Nationwide Children’s Hospital, and Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Jackson’s research program focuses on understanding the role and response of the renal urothelium during urinary tract obstruction. Urinary Tract Obstruction (UTO) is a leading cause of pediatric chronic kidney disease (CKD) and end stage renal disease. Apart from surgery to relieve UTO, no specific interventions can prevent or limit obstructive nephropathy (UTO induced kidney injury and dysfunction). Dr. Jackson discovered that renal urothelial remodeling is a unifying and protective feature of both congenital and acquired forms of urinary tract obstruction. Her research supports the hypothesis that the renal urothelium represents the front line of defense to urinary tract obstruction, and a novel target for the development of therapies to mitigate obstructive kidney disease.   

Biography

Ashley R. Jackson, PhD, is a Principal Investigator in the Center for Clinical and Translational Research and member of the Division of Pediatric Nephrology and Hypertension at Nationwide Children’s Hospital, and Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Jackson’s research program focuses on understanding the role and response of the renal urothelium during urinary tract obstruction. Urinary Tract Obstruction (UTO) is a leading cause of pediatric chronic kidney disease (CKD) and end stage renal disease. Apart from surgery to relieve UTO, no specific interventions can prevent or limit obstructive nephropathy (UTO induced kidney injury and dysfunction). Dr. Jackson discovered that renal urothelial remodeling is a unifying and protective feature of both congenital and acquired forms of urinary tract obstruction. Her research supports the hypothesis that the renal urothelium represents the front line of defense to urinary tract obstruction, and a novel target for the development of therapies to mitigate obstructive kidney disease.   

Ashley R. Jackson, PhD, is a Principal Investigator in the Center for Clinical and Translational Research and member of the Division of Pediatric Nephrology and Hypertension at Nationwide Children’s Hospital, and Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Jackson’s research program focuses on understanding the role and response of the renal urothelium during urinary tract obstruction. Urinary Tract Obstruction (UTO) is a leading cause of pediatric chronic kidney disease (CKD) and end stage renal disease. Apart from surgery to relieve UTO, no specific interventions can prevent or limit obstructive nephropathy (UTO induced kidney injury and dysfunction). Dr. Jackson discovered that renal urothelial remodeling is a unifying and protective feature of both congenital and acquired forms of urinary tract obstruction. Her research supports the hypothesis that the renal urothelium represents the front line of defense to urinary tract obstruction, and a novel target for the development of therapies to mitigate obstructive kidney disease.   

Ashley R. Jackson, PhD, is a Principal Investigator in the Center for Clinical and Translational Research and member of the Division of Pediatric Nephrology and Hypertension at Nationwide Children’s Hospital, and Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Jackson’s research program focuses on understanding the role and response of the renal urothelium during urinary tract obstruction.

Urinary Tract Obstruction (UTO) is a leading cause of pediatric chronic kidney disease (CKD) and end stage renal disease. Apart from surgery to relieve UTO, no specific interventions can prevent or limit obstructive nephropathy (UTO induced kidney injury and dysfunction).

Dr. Jackson discovered that renal urothelial remodeling is a unifying and protective feature of both congenital and acquired forms of urinary tract obstruction. Her research supports the hypothesis that the renal urothelium represents the front line of defense to urinary tract obstruction, and a novel target for the development of therapies to mitigate obstructive kidney disease. 

 

Academic and Clinical Areas

Nephrology and Urology Research Affinity Group

Faculty

Primary Department

Kidney and Urinary Tract Center

Academic and Clinical Areas

Nephrology and Urology Research Affinity Group

Faculty

Primary Department

Kidney and Urinary Tract Center

Academic and Clinical Areas

Nephrology and Urology Research Affinity Group

Faculty

Primary Department

Kidney and Urinary Tract Center

Nephrology and Urology Research Affinity Group

Faculty

Primary Department

Kidney and Urinary Tract Center

  • Nephrology and Urology Research Affinity Group
  • Faculty
  • Primary Department
  • Kidney and Urinary Tract Center

Research

Dr. Jackson’s lab uses powerful pre-clinical models, cutting-edge organoid models, and transcriptomics to investigate the renal urothelial stem cell and its governing pathways during development and repair. These efforts form the foundation for the development of novel therapies that may mitigate obstructive kidney disease. Publications

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE. Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. J Clin Invest. 2019 Dec 2; 129: 5374-5380.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Gupta S, Jackson AR, DaJusta DG, McLeod DJ, Alpert SA, Jayanthi VR, McHugh K, Schwaderer AR, Becknell B, Ching CB. Urinary antimicrobial peptides: Potential novel biomarkers of obstructive uropathy. J Pediatr Urol. 2018 Jun; 14: 238.e1-238.e6.

                


                  Carpenter AR, McHugh KM. Role of renal urothelium in the development and progression of kidney disease. Pediatr Nephrol. 2017 Apr; 32: 557-564.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

Research

Dr. Jackson’s lab uses powerful pre-clinical models, cutting-edge organoid models, and transcriptomics to investigate the renal urothelial stem cell and its governing pathways during development and repair. These efforts form the foundation for the development of novel therapies that may mitigate obstructive kidney disease. Publications

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE. Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. J Clin Invest. 2019 Dec 2; 129: 5374-5380.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Gupta S, Jackson AR, DaJusta DG, McLeod DJ, Alpert SA, Jayanthi VR, McHugh K, Schwaderer AR, Becknell B, Ching CB. Urinary antimicrobial peptides: Potential novel biomarkers of obstructive uropathy. J Pediatr Urol. 2018 Jun; 14: 238.e1-238.e6.

                


                  Carpenter AR, McHugh KM. Role of renal urothelium in the development and progression of kidney disease. Pediatr Nephrol. 2017 Apr; 32: 557-564.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

Research

Dr. Jackson’s lab uses powerful pre-clinical models, cutting-edge organoid models, and transcriptomics to investigate the renal urothelial stem cell and its governing pathways during development and repair. These efforts form the foundation for the development of novel therapies that may mitigate obstructive kidney disease. Publications

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE. Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. J Clin Invest. 2019 Dec 2; 129: 5374-5380.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Gupta S, Jackson AR, DaJusta DG, McLeod DJ, Alpert SA, Jayanthi VR, McHugh K, Schwaderer AR, Becknell B, Ching CB. Urinary antimicrobial peptides: Potential novel biomarkers of obstructive uropathy. J Pediatr Urol. 2018 Jun; 14: 238.e1-238.e6.

                


                  Carpenter AR, McHugh KM. Role of renal urothelium in the development and progression of kidney disease. Pediatr Nephrol. 2017 Apr; 32: 557-564.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

Dr. Jackson’s lab uses powerful pre-clinical models, cutting-edge organoid models, and transcriptomics to investigate the renal urothelial stem cell and its governing pathways during development and repair. These efforts form the foundation for the development of novel therapies that may mitigate obstructive kidney disease. Publications

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE. Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. J Clin Invest. 2019 Dec 2; 129: 5374-5380.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Gupta S, Jackson AR, DaJusta DG, McLeod DJ, Alpert SA, Jayanthi VR, McHugh K, Schwaderer AR, Becknell B, Ching CB. Urinary antimicrobial peptides: Potential novel biomarkers of obstructive uropathy. J Pediatr Urol. 2018 Jun; 14: 238.e1-238.e6.

                


                  Carpenter AR, McHugh KM. Role of renal urothelium in the development and progression of kidney disease. Pediatr Nephrol. 2017 Apr; 32: 557-564.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

Dr. Jackson’s lab uses powerful pre-clinical models, cutting-edge organoid models, and transcriptomics to investigate the renal urothelial stem cell and its governing pathways during development and repair. These efforts form the foundation for the development of novel therapies that may mitigate obstructive kidney disease.

                  Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;  

                


                  Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.

                


                  Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE. Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. J Clin Invest. 2019 Dec 2; 129: 5374-5380.

                


                  Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.

                


                  Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.

                


                  Gupta S, Jackson AR, DaJusta DG, McLeod DJ, Alpert SA, Jayanthi VR, McHugh K, Schwaderer AR, Becknell B, Ching CB. Urinary antimicrobial peptides: Potential novel biomarkers of obstructive uropathy. J Pediatr Urol. 2018 Jun; 14: 238.e1-238.e6.

                


                  Carpenter AR, McHugh KM. Role of renal urothelium in the development and progression of kidney disease. Pediatr Nephrol. 2017 Apr; 32: 557-564.

                


                  Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.

                


                  Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

View More Publications

  • Jackson AR, Narla ST, Bates CM, Becknell B. Urothelial progenitors in development and repair. Pediatr Nephrol. 2021 Sep 2;
  • Jackson AR, Ching CB, McHugh KM, Becknell B. Roles for urothelium in normal and aberrant urinary tract development. Nat Rev Urol. 2020 Aug; 17: 459-468.
  • Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D’Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE. Loss-of-function variants in myocardin cause congenital megabladder in humans and mice. J Clin Invest. 2019 Dec 2; 129: 5374-5380.
  • Jackson AR, Hoff ML, Li B, Ching CB, McHugh KM, Becknell B. Krt5+ urothelial cells are developmental and tissue repair progenitors in the kidney. Am J Physiol Renal Physiol. 2019 Sep 1; 317: F757-F766.
  • Jackson AR, Li B, Cohen SH, Ching CB, McHugh KM, Becknell B. The uroplakin plaque promotes renal structural integrity during congenital and acquired urinary tract obstruction. Am J Physiol Renal Physiol. 2018 Oct 1; 315: F1019-F1031.
  • Gupta S, Jackson AR, DaJusta DG, McLeod DJ, Alpert SA, Jayanthi VR, McHugh K, Schwaderer AR, Becknell B, Ching CB. Urinary antimicrobial peptides: Potential novel biomarkers of obstructive uropathy. J Pediatr Urol. 2018 Jun; 14: 238.e1-238.e6.
  • Carpenter AR, McHugh KM. Role of renal urothelium in the development and progression of kidney disease. Pediatr Nephrol. 2017 Apr; 32: 557-564.
  • Wilhide ME, Feller JD, Li B, Mohamed AZ, Becknell B, Jackson AR, McHugh KM, Ingraham SE. Renal epithelial miR-205 expression correlates with disease severity in a mouse model of congenital obstructive nephropathy. Pediatr Res. 2016 Oct; 80: 602-9.
  • Carpenter AR, Becknell MB, Ching CB, Cuaresma EJ, Chen X, Hains DS, McHugh KM. Uroplakin 1b is critical in urinary tract development and urothelial differentiation and homeostasis. Kidney Int. 2016 Mar; 89: 612-24.

Education

Date of Appointment at Nationwide Children’s Hospital: 09/01/2020

Fellowship

Nationwide Children’s Hospital

Date Completed: 08/31/2020

Graduate School

The Ohio State University

Date Completed: 05/31/2016

Education

Date of Appointment at Nationwide Children’s Hospital: 09/01/2020

Fellowship

Nationwide Children’s Hospital

Date Completed: 08/31/2020

Graduate School

The Ohio State University

Date Completed: 05/31/2016

Education

Date of Appointment at Nationwide Children’s Hospital: 09/01/2020

Fellowship

Nationwide Children’s Hospital

Date Completed: 08/31/2020

Graduate School

The Ohio State University

Date Completed: 05/31/2016

Date of Appointment at Nationwide Children’s Hospital: 09/01/2020

Fellowship

Nationwide Children’s Hospital

Date Completed: 08/31/2020

Graduate School

The Ohio State University

Date Completed: 05/31/2016

Date of Appointment at Nationwide Children’s Hospital: 09/01/2020

Fellowship

Nationwide Children’s Hospital

Date Completed: 08/31/2020

Graduate School

The Ohio State University

Date Completed: 05/31/2016

Contact Information

Kidney and Urinary Tract Center

Call us at: (614) 355-2879

Email Ashley R Jackson

                    700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Kidney and Urinary Tract Center

Call us at: (614) 355-2879

Email Ashley R Jackson

                    700 Children's DriveColumbus, OH 43205 (map)

Contact Information

Kidney and Urinary Tract Center

Call us at: (614) 355-2879

Email Ashley R Jackson

                    700 Children's DriveColumbus, OH 43205 (map)

Kidney and Urinary Tract Center

Call us at: (614) 355-2879

Email Ashley R Jackson

                    700 Children's DriveColumbus, OH 43205 (map)

Call us at: (614) 355-2879

Email Ashley R Jackson

                    700 Children's DriveColumbus, OH 43205 (map)

Call us at: (614) 355-2879

Email Ashley R Jackson

                    700 Children's DriveColumbus, OH 43205 (map)
  • Call us at:
  • (614) 355-2879
  • Email Ashley R Jackson
  • 700 Children’s DriveColumbus, OH 43205 (map)